MCID: HYP457
MIFTS: 48

Hypertrophic Scars malady

Skin diseases category

Summaries for Hypertrophic Scars

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

MalaCards: Hypertrophic Scars, also known as scars hypertrophic, is related to systemic scleroderma and burn scar. An important gene associated with Hypertrophic Scars is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are p70S6K Signaling and Malaria. The compounds procollagen and benzylamide have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Hypertrophic Scars

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32MalaCards, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrophic scars 32
scars hypertrophic 44


External Ids:

ICD1025 L91.0

Related Diseases for Hypertrophic Scars

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1systemic scleroderma30.0BMP6, DCN, CD36, TGFB1
2burn scar10.7
3burns10.7
4scar contracture10.4
5ehlers-danlos syndrome type viib10.2
6type vi ehlers-danlos syndrome10.1
7epidermolysis bullosa dystrophica, ar10.1
8diabetic foot ulcers10.0
9breast reconstruction10.0
10retinopathy of prematurity10.0
11limited scleroderma10.0
12menkes disease10.0
13rubinstein-taybi syndrome10.0
14porphyria cutanea tarda10.0
15epidermolysis bullosa simplex10.0
16leber congenital amaurosis10.0
17type i ehlers-danlos syndrome10.0
18epidermolysis bullosa acquisita10.0
19folliculitis10.0
20mixed connective tissue disease10.0
21oculocerebrorenal syndrome10.0
22cleft lip10.0
23osteopoikilosis10.0
24chickenpox10.0
25lipoid proteinosis10.0
26epidermolysis bullosa dystrophica10.0
27laryngotracheitis10.0
28basal cell carcinoma10.0
29impetigo10.0
30neurofibroma10.0
31obesity10.0
32turner syndrome10.0
33ehlers-danlos syndrome, hypermobility type10.0
34ehlers-danlos syndrome type iv10.0
35kindler syndrome10.0
36cockayne syndrome type ii10.0
37occipital horn syndrome10.0
38ehlers-danlos syndrome dermatosparaxis type10.0
39epidermolysis bullosa simplex, dowling-meara type10.0
40epidermolysis bullosa, pretibial10.0
41varicella virus antenatal infection10.0
42quinquaud's decalvans folliculitis10.0
43torticollis keloids cryptorchidism renal dysplasia10.0
44supraumbilical midabdominal raphe and facial cavernous hemangiomas10.0
45ulerythema ophryogenesis10.0
46loeys-dietz syndrome type 1a10.0
47mandibuloacral dysplasia with type b lipodystrophy10.0
48pemphigus vulgaris10.0
49recessive dystrophic epidermolysis bullosa, generalized, other10.0
50epidermolysis bullosa dystrophica, ad10.0

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to hypertrophic scars

Clinical Features for Hypertrophic Scars

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Drugs & Therapeutics for Hypertrophic Scars

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypertrophic Scars

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Genetic Tests for Hypertrophic Scars

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Anatomical Context for Hypertrophic Scars

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32MalaCards
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MalaCards organs/tissues related to Hypertrophic Scars:

32
Skin, Endothelial, Breast

Animal Models for Hypertrophic Scars or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertrophic Scars:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6TGFB1, DCN, AGTR2, MAPK7, CD36, FST
2MP:000536910.6DCN, AGTR2, CD36, FGF2, FST, THBS4
3MP:001077110.5DCN, AGTR2, FST, KRT16, KRT14, TGFB1
4MP:000537510.4DPT, CD36, ADAMTS1, TGFB1, AGTR2
5MP:000537610.4DCN, AGTR2, MAPK7, CD36, FGF2, FST
6MP:000538410.4CD36, MAPK7, AGTR2, DCN, FGF2, MMP28
7MP:000539110.3DCN, DPT, CD36, FGF2, FST, KRT14
8MP:000537810.1BMP6, DCN, AGTR2, MAPK7, CD36, FST

Publications for Hypertrophic Scars

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50PubMed
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Articles related to Hypertrophic Scars:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Elevated expression of pleiotrophin in human hypertrophic scars. (23054143)
2013
2
The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar. (23303450)
2013
3
Management of Hypertrophic Burn Scar: A Comparison between the Efficacy of Exercise-Physiotherapy and Pressure Garment-Silicone on Hypertrophic Scar. (23785579)
2013
4
Expression of beta-endorphin in hypertrophic scar and its relationship with pruritus]. (22792774)
2012
5
Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars. (22237724)
2012
6
Curative effects of oleanolic Acid on formed hypertrophic scars in the rabbit ear model. (23326292)
2012
7
Quantification of the physical properties of keloid and hypertrophic scars using the Vesmeter novel sensing device. (22248369)
2012
8
Intralesional cryosurgery and intralesional steroid injection: a good combination therapy for treatment of keloids and hypertrophic scars. (22913446)
2012
9
Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts. (22350758)
2012
10
Clinical inquiry: What treatment is best for hypertrophic scars and keloids? (22163360)
2011
11
Topical modalities for treatment and prevention of postsurgical hypertrophic scars. (21856542)
2011
12
An evaluation of evidence regarding application of silicone gel sheeting for the management of hypertrophic scars and keloids. (21103316)
2010
13
Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial. (20626444)
2010
14
The effect of angiotensin II on phosphoinositide-3 kinase/Akt cascade in cultured fibroblasts derived from patients with hypertrophic scars]. (20432929)
2010
15
Intralesional cryosurgery for the treatment of hypertrophic scars and keloids. (21042160)
2010
16
Function of STAT1 in proliferation and differentiation of human hypertrophic scar fibroblast induced by connective tissue growth factor]. (19595136)
2009
17
Basic fibroblast growth factor: a potential new therapeutic tool for the treatment of hypertrophic and keloid scars. (19071002)
2009
18
Fractional photothermolysis for the treatment of hypertrophic scars: clinical experience of eight cases. (19389105)
2009
19
Treatment of hypertrophic scars and keloids using intense pulsed light (IPL). (18560927)
2008
20
Isolation, culture and characterization of endothelial cells from human hypertrophic scar. (18568951)
2008
21
Role of angiotensin II receptors in proliferation of fibroblast derived from human hypertrophic scars]. (17393691)
2007
22
Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. (16918564)
2006
23
Signal roles of protein tyrosine kinase in transforming growth factor-beta1, or interferon-gamma regulated proliferation and collagen synthesis by fibroblasts from hypertrophic scar and normal dermis]. (15844596)
2005
24
Expression and significance of TRAIL receptors in fibroblasts of hypertrophic scar]. (16463784)
2005
25
The expression of tenascin-C mRNA in keloids and hypertrophic scars]. (15844597)
2005
26
Gene expression of stress activated protein kinase and its MAPKs in hypertrophic scar]. (14768075)
2004
27
Hexose sugars differentially alter collagen gene expression and synthesis in fibroblasts derived from granulation tissue, hypertrophic scar and keloid. (15045512)
2004
28
Hypertrophic scars and keloids: etiology and management. (12680802)
2003
29
Role of HLA-DR and CD1a molecules in pathogenesis of hypertrophic scarring and keloids. (12775256)
2003
30
Experimental study of the expression of c-myc, c-fos and proto-oncogenes on hypertrophic and scars]. (12189705)
2002
31
Topigel in the treatment of hypertrophic scars after burn injuries. (12053431)
2002
32
Expression of oncoproteins c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor. (11780366)
2001
33
New concept of balloon-compression wear for the treatment of keloids and hypertrophic scars. (11604673)
2001
34
Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo. (10714549)
2000
35
Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. (9232700)
1997
36
Mechanical properties of normal skin and hypertrophic scars. (8884002)
1996
37
Aetiology and management of hypertrophic scars and keloids. (8943647)
1996
38
Influence of free residual chlorine on cultured human epidermal keratinocytes from normal skin and hypertrophic scars. (7577833)
1995
39
The protruding scars: keloids and hypertrophic diagnosis and treatment with silicon-gel-sheeting. (7971533)
1994
40
Management of hypertrophic scars on the pubic area with an iliac flap. (1892555)
1991
41
Proteoglycan-lymphocyte association in the development of hypertrophic scars. (2108695)
1990
42
Implants of hypertrophic scars and keloids into the nude (athymic) mouse: viability and morphology. (2724385)
1989
43
A protocol for the treatment of hypertrophic scars and keloids. (3577941)
1987
44
Tissue expansion in the treatment of hypertrophic scars and scar contractures. (3704700)
1986
45
Changes in type of collagen during the development of human post-burn hypertrophic scars. (436291)
1979
46
Combined modalities in the management of hypertrophic scars and keloids. (501782)
1979
47
Differential diagnosis of keloids and hypertrophic scars by tissue culture technique with notes on therapy of keloids by surgical excision and decadron. (13811659)
1960
48
Local factors in the histogenesis of hypertrophic scars. (14858797)
1951
49
Keloids and hypertrophic scars. (18102775)
1948
50
Impetigo with Hypertrophic Scar Formation. (19984924)
1926

Genetic Variations for Hypertrophic Scars

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Expression for genes affiliated with Hypertrophic Scars

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for genes affiliated with Hypertrophic Scars

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 55SinoBiological
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Compounds for genes affiliated with Hypertrophic Scars

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1procollagen4410.9TGFB1, P4HTM
2benzylamide4410.9FGF2, CD36, TGFB1
3estrogen4410.9DGKQ
4alginate4410.9DCN, CD36, TGFB1, FGF2
5pge24410.9TGFB1
6hydroxyproline44 11 2412.9P4HTM, DCN, BMP6, TGFB1, CD36
7chondroitin sulfate44 2411.9FGF2, ADAMTS1, CD36, DCN, BMP6
8glycosaminoglycan4410.9DCN, BMP6, CD36, TGFB1, FGF2
9heparin44 28 11 2413.8CD36, THBS4, ADAMTS1, BMP6, DCN
10dermatan sulfate4410.8FGF2, CD36, DCN, BMP6
11hyaluronic acid44 2411.8TGFB1, DCN, BMP6, CD36, FGF2
12tgf beta14410.8TGFB1, BMP6, DCN, CD36, FGF2, FST
13paraffin4410.8TGFB1, CD36, DCN, KRT14, KRT16, FGF2
14sodium dodecylsulfate4410.8BMP6, FGF2, FST, KRT16, DCN, DGKQ
15losartan44 49 28 1113.8AGTR2, CD36, TGFB1, BMP6
16calcitriol44 59 11 2413.8KRT16, TGFB1, FGF2, BMP6, CD36
17bromodeoxyuridine4410.8KRT14, BMP6, FGF2, TGFB1, FST
18pirfenidone44 5911.8BMP6, TGFB1, CD36
19serine4410.8THBS4, MAPK7, FGF2, DGKQ, TGFB1, ADAMTS1
20bleomycin44 1111.8TGFB1, FGF2, BMP6, DCN
21vitamin e succinate4410.8BMP6, TGFB1, FGF2
22matrigel4410.8BMP6, TGFB1, FGF2, DCN, CD36
23l-ascorbic acid 2-phosphate4410.8CD36, TGFB1
24retinoic acid44 2411.8BMP6, TGFB1, KRT14, CD36, DCN, FGF2
25hydrocortisone44 2 59 1113.8FGF2, KRT14, BMP6, CD36
26creatinine4410.8AGTR2, BMP6, DCN, TGFB1, FST, CD36
27troglitazone44 28 59 1113.8TGFB1, KRT14, CD36, BMP6
28tyrosine4410.8DGKQ, FST, TGFB1I1, KRT14, THBS4, MAPK7
29halofuginone4410.8CD36, BMP6
30alanine4410.8AGTR2, THBS4, FGF2, KRT14, DCN, BMP6
31ang ii4410.8AGTR2, CD36, TGFB1
32pd 98,0594410.7MAPK7, BMP6, DCN, FGF2, TGFB1
33dihydrotestosterone44 28 11 2413.7FGF2, BMP6, FST, TGFB1
34cmdb74410.7TGFB1, FGF2
35h2o24410.7TGFB1I1, FGF2, CD36, MAPK7, BMP6, DGKQ
36genistein44 28 59 2 11 2415.7DCN, MAPK7, CD36, FGF2, FST
37dexamethasone44 49 28 1113.7DCN, FST, BMP6, TGFB1, FGF2
38cyclosporin a44 28 5912.7FGF2, BMP6, DCN, AGTR2, TGFB1
39vitamin a44 11 2412.7FGF2, KRT14, KRT16, FST
40vegf4410.7BMP6, CD36, FST, FGF2, TGFB1, DCN
41nitric oxide44 11 2412.6DGKQ, BMP6, DCN, KRT16, AGTR2, FST
4215-deoxy-delta-12,14-prostaglandin j24410.6FGF2, CD36, BMP6
43thymidine44 2411.6FGF2, BMP6, ADAMTS1, TGFB1, FST
44tranilast4410.6TGFB1, BMP6
45ribonucleic acid4410.5TGFB1, FST, DCN, BMP6
46pd12331944 2811.5CD36, AGTR2
47sb 20358044 5911.4CD36, FGF2, BMP6, TGFB1
48vitamin d4410.4KRT14, CD36, BMP6, TGFB1
49tamoxifen44 49 28 1113.3KRT14, DGKQ, TGFB1
50polysaccharide4410.2DCN

GO Terms for genes affiliated with Hypertrophic Scars

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16Gene Ontology
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Cellular components related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4DCN, DPT, FGF2, THBS4, TGFB1, BMP6
2extracellular matrixGO:03101210.1TGFB1I1, THBS4, DPT, DCN

Biological processes related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood vessel endothelial cell migrationGO:04353710.7TGFB1, FGF2, AGTR2
2positive regulation of cell divisionGO:05178110.6TGFB1, THBS4, FGF2
3negative regulation of cell proliferationGO:00828510.6DPT, FGF2, ADAMTS1, TGFB1I1, TGFB1
4positive regulation of endothelial cell proliferationGO:00193810.6BMP6, FGF2, THBS4
5cellular response to dexamethasone stimulusGO:07154910.5TGFB1, AGTR2
6nitric oxide mediated signal transductionGO:00726310.5CD36, AGTR2
7kidney developmentGO:00182210.4ADAMTS1, DCN, BMP6
8hyaluronan catabolic processGO:03021410.4FGF2, TGFB1
9hematopoietic progenitor cell differentiationGO:00224410.1TGFB1, FST

Molecular functions related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4TGFB1, THBS4, FGF2, BMP6

Products for genes affiliated with Hypertrophic Scars

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  • Antibodies
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Sources for Hypertrophic Scars

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet