MCID: HYP457
MIFTS: 48

Hypertrophic Scars malady

Skin diseases category

Summaries for Hypertrophic Scars

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

MalaCards: Hypertrophic Scars, also known as scars hypertrophic, is related to systemic scleroderma and burn scar. An important gene associated with Hypertrophic Scars is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are p70S6K Signaling and Malaria. The compounds procollagen and benzylamide have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Hypertrophic Scars

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Sources:
32MalaCards, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrophic scars 32
scars hypertrophic 44


External Ids:

ICD1025 L91.0

Related Diseases for Hypertrophic Scars

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1systemic scleroderma30.0BMP6, DCN, CD36, TGFB1
2burn scar10.7
3burns10.7
4scar contracture10.4
5ehlers-danlos syndrome type viib10.2
6type vi ehlers-danlos syndrome10.1
7epidermolysis bullosa dystrophica, ar10.1
8diabetic foot ulcers10.0
9breast reconstruction10.0
10retinopathy of prematurity10.0
11limited scleroderma10.0
12menkes disease10.0
13rubinstein-taybi syndrome10.0
14porphyria cutanea tarda10.0
15epidermolysis bullosa simplex10.0
16leber congenital amaurosis10.0
17type i ehlers-danlos syndrome10.0
18epidermolysis bullosa acquisita10.0
19folliculitis10.0
20mixed connective tissue disease10.0
21oculocerebrorenal syndrome10.0
22cleft lip10.0
23osteopoikilosis10.0
24chickenpox10.0
25lipoid proteinosis10.0
26epidermolysis bullosa dystrophica10.0
27laryngotracheitis10.0
28basal cell carcinoma10.0
29impetigo10.0
30neurofibroma10.0
31obesity10.0
32turner syndrome10.0
33ehlers-danlos syndrome, hypermobility type10.0
34ehlers-danlos syndrome type iv10.0
35kindler syndrome10.0
36cockayne syndrome type ii10.0
37occipital horn syndrome10.0
38ehlers-danlos syndrome dermatosparaxis type10.0
39epidermolysis bullosa simplex, dowling-meara type10.0
40epidermolysis bullosa, pretibial10.0
41varicella virus antenatal infection10.0
42quinquaud's decalvans folliculitis10.0
43torticollis keloids cryptorchidism renal dysplasia10.0
44supraumbilical midabdominal raphe and facial cavernous hemangiomas10.0
45ulerythema ophryogenesis10.0
46loeys-dietz syndrome type 1a10.0
47mandibuloacral dysplasia with type b lipodystrophy10.0
48pemphigus vulgaris10.0
49recessive dystrophic epidermolysis bullosa, generalized, other10.0
50epidermolysis bullosa dystrophica, ad10.0

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to hypertrophic scars

Clinical Features for Hypertrophic Scars

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Drugs & Therapeutics for Hypertrophic Scars

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypertrophic Scars

Search CenterWatch for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

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Anatomical Context for Hypertrophic Scars

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32MalaCards
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MalaCards organs/tissues related to Hypertrophic Scars:

32
Skin, Endothelial, Breast

Animal Models for Hypertrophic Scars or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertrophic Scars:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6TGFB1, DCN, AGTR2, MAPK7, CD36, FST
2MP:000536910.6DCN, AGTR2, CD36, FGF2, FST, THBS4
3MP:001077110.5DCN, AGTR2, FST, KRT16, KRT14, TGFB1
4MP:000537510.4DPT, CD36, ADAMTS1, TGFB1, AGTR2
5MP:000537610.4DCN, AGTR2, MAPK7, CD36, FGF2, FST
6MP:000538410.4CD36, MAPK7, AGTR2, DCN, FGF2, MMP28
7MP:000539110.3DCN, DPT, CD36, FGF2, FST, KRT14
8MP:000537810.1BMP6, DCN, AGTR2, MAPK7, CD36, FST

Publications for Hypertrophic Scars

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50PubMed
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Articles related to Hypertrophic Scars:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Adjuvant chemotherapy reduces the incidence of abdominal hypertrophic scarring following immediate TRAM breast reconstruction. (23283525)
2013
2
The effect of integrin-linked kinase on VEGF expression in fibroblasts from human hypertrophic scar]. (22097317)
2011
3
Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars. (21635262)
2011
4
Immunohistochemical expression of TGF-I^1 in keloids and hypertrophic scars. (20559120)
2011
5
The length-control suture: a new method for prevention of hypertrophic scars and dog-ears. (21407069)
2011
6
Intralesional pentoxifylline as an adjuvant treatment for perioral post-burn hypertrophic scars. (20064692)
2010
7
The expression of Cyclin A and p21cip1 in fibroblast of hypertrophic scar]. (21046779)
2010
8
Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. (20203286)
2010
9
Recombinant human decorin inhibits TGF-beta1-induced contraction of collagen lattice by hypertrophic scar fibroblasts. (19167828)
2009
10
Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars. (19766399)
2009
11
Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. (19018794)
2009
12
Efficacy of a polyurethane dressing versus a soft silicone sheet on hypertrophic scars. (19440173)
2009
13
Morphological analysis of the connective tissue reaction in linear hypertrophic scars treated with intralesional steroid or silicone-gel sheeting. A light and electron microscopic study. (18637554)
2008
14
Expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta1. (18616749)
2008
15
Keloids and hypertrophic scars: are they two different sides of the same coin? (18177398)
2008
16
An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. (18798752)
2008
17
Lipid analysis of normal dermis and hypertrophic scars. (18028131)
2007
18
Postoperative radiation protocol for keloids and hypertrophic scars: statistical analysis of 370 sites followed for over 18 months. (18046154)
2007
19
Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. (17688405)
2007
20
Variations in gap junctional intercellular communication and connexin expression in fibroblasts derived from keloid and hypertrophic scars. (17312486)
2007
21
Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. (18457258)
2007
22
New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. (16875473)
2006
23
The experimental study of mechanism of integrin in hypertrophic scar contracture]. (16573163)
2006
24
Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars. (15772942)
2005
25
High resolution B-scan ultrasound of hypertrophic scars. (15998329)
2005
26
A study of the abnormalities of human epiderm in keloids and hypertrophic scars]. (15363271)
2004
27
Painless steroid injections for hypertrophic scars and keloids. (12706172)
2003
28
Intralesional cryotherapy for enhancing the involution of hypertrophic scars and keloids. (12711943)
2003
29
Detection of collagens in hypertrophic scars by picrosirius polarization method. (12390767)
2002
30
Subdermabrasion in the treatment of post-burn facial hypertrophic scars. (12016501)
2002
31
Scar contractures, hypertrophic scars, and keloids. (11735059)
2001
32
The mode of action of prostaglandin (PG) I1 analog, SM-10906, on fibroblasts of hypertrophic scars is similar to PGE1 in its potential role of preventing scar formation. (9412820)
1997
33
Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. (9162737)
1997
34
Topical putrescine (Fibrostat) in treatment of hypertrophic scars: phase II study. (8532768)
1996
35
Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts. (7979045)
1994
36
Regulation of collagen synthesis and messenger RNA levels in normal and hypertrophic scar fibroblasts in vitro by interferon alfa-2b. (17163884)
1993
37
Keloids and hypertrophic scars. (8349914)
1993
38
Comparative study of Langerhans cells in normal and pathological human scars. II. Hypertrophic scars. (1374665)
1992
39
The progress of hypertrophic scars monitored by ultrasound measurements of thickness. (1418506)
1992
40
Keloids and hypertrophic scars. (2217605)
1990
41
Some observations on the surface structure of collagen in hypertrophic scars. (3986642)
1985
42
Comparative ultrastructure of hypertrophic scars and keloids. (6740239)
1984
43
Measurement of collagen-proteoglycan interaction in hypertrophic scars. (6190191)
1983
44
The etiology of hypertrophic scar contracture: another view. (6453353)
1981
45
Plastic surgery-epitomes of progress: triamcinolone for hypertrophic scars and keloids. (18748646)
1980
46
Collagen biosynthesis in normal and hypertrophic scars and keloid as a function of the duration of the scar. (1174820)
1975
47
Keloids and hypertrophic scars. (6037887)
1967
48
Hypertrophic scars and keloids. (13008023)
1953
49
Radiotherapy in the prevention and treatment of hypertrophic scars. (14858798)
1951
50
Hypertrophic scars. (14858800)
1951

Genetic Variations for Hypertrophic Scars

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Expression for genes affiliated with Hypertrophic Scars

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for genes affiliated with Hypertrophic Scars

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 55SinoBiological
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Compounds for genes affiliated with Hypertrophic Scars

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1procollagen4410.9TGFB1, P4HTM
2benzylamide4410.9FGF2, CD36, TGFB1
3estrogen4410.9DGKQ
4alginate4410.9DCN, CD36, TGFB1, FGF2
5pge24410.9TGFB1
6hydroxyproline44 11 2412.9P4HTM, DCN, BMP6, TGFB1, CD36
7chondroitin sulfate44 2411.9FGF2, ADAMTS1, CD36, DCN, BMP6
8glycosaminoglycan4410.9DCN, BMP6, CD36, TGFB1, FGF2
9heparin44 28 11 2413.8CD36, THBS4, ADAMTS1, BMP6, DCN
10dermatan sulfate4410.8FGF2, CD36, DCN, BMP6
11hyaluronic acid44 2411.8TGFB1, DCN, BMP6, CD36, FGF2
12tgf beta14410.8TGFB1, BMP6, DCN, CD36, FGF2, FST
13paraffin4410.8TGFB1, CD36, DCN, KRT14, KRT16, FGF2
14sodium dodecylsulfate4410.8BMP6, FGF2, FST, KRT16, DCN, DGKQ
15losartan44 49 28 1113.8AGTR2, CD36, TGFB1, BMP6
16calcitriol44 59 11 2413.8KRT16, TGFB1, FGF2, BMP6, CD36
17bromodeoxyuridine4410.8KRT14, BMP6, FGF2, TGFB1, FST
18pirfenidone44 5911.8BMP6, TGFB1, CD36
19serine4410.8THBS4, MAPK7, FGF2, DGKQ, TGFB1, ADAMTS1
20bleomycin44 1111.8TGFB1, FGF2, BMP6, DCN
21vitamin e succinate4410.8BMP6, TGFB1, FGF2
22matrigel4410.8BMP6, TGFB1, FGF2, DCN, CD36
23l-ascorbic acid 2-phosphate4410.8CD36, TGFB1
24retinoic acid44 2411.8BMP6, TGFB1, KRT14, CD36, DCN, FGF2
25hydrocortisone44 2 59 1113.8FGF2, KRT14, BMP6, CD36
26creatinine4410.8AGTR2, BMP6, DCN, TGFB1, FST, CD36
27troglitazone44 28 59 1113.8TGFB1, KRT14, CD36, BMP6
28tyrosine4410.8DGKQ, FST, TGFB1I1, KRT14, THBS4, MAPK7
29halofuginone4410.8CD36, BMP6
30alanine4410.8AGTR2, THBS4, FGF2, KRT14, DCN, BMP6
31ang ii4410.8AGTR2, CD36, TGFB1
32pd 98,0594410.7MAPK7, BMP6, DCN, FGF2, TGFB1
33dihydrotestosterone44 28 11 2413.7FGF2, BMP6, FST, TGFB1
34cmdb74410.7TGFB1, FGF2
35h2o24410.7TGFB1I1, FGF2, CD36, MAPK7, BMP6, DGKQ
36genistein44 28 59 2 11 2415.7DCN, MAPK7, CD36, FGF2, FST
37dexamethasone44 49 28 1113.7DCN, FST, BMP6, TGFB1, FGF2
38cyclosporin a44 28 5912.7FGF2, BMP6, DCN, AGTR2, TGFB1
39vitamin a44 11 2412.7FGF2, KRT14, KRT16, FST
40vegf4410.7BMP6, CD36, FST, FGF2, TGFB1, DCN
41nitric oxide44 11 2412.6DGKQ, BMP6, DCN, KRT16, AGTR2, FST
4215-deoxy-delta-12,14-prostaglandin j24410.6FGF2, CD36, BMP6
43thymidine44 2411.6FGF2, BMP6, ADAMTS1, TGFB1, FST
44tranilast4410.6TGFB1, BMP6
45ribonucleic acid4410.5TGFB1, FST, DCN, BMP6
46pd12331944 2811.5CD36, AGTR2
47sb 20358044 5911.4CD36, FGF2, BMP6, TGFB1
48vitamin d4410.4KRT14, CD36, BMP6, TGFB1
49tamoxifen44 49 28 1113.3KRT14, DGKQ, TGFB1
50polysaccharide4410.2DCN

GO Terms for genes affiliated with Hypertrophic Scars

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16Gene Ontology
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Cellular components related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4DCN, DPT, FGF2, THBS4, TGFB1, BMP6
2extracellular matrixGO:03101210.1TGFB1I1, THBS4, DPT, DCN

Biological processes related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood vessel endothelial cell migrationGO:04353710.7TGFB1, FGF2, AGTR2
2positive regulation of cell divisionGO:05178110.6TGFB1, THBS4, FGF2
3negative regulation of cell proliferationGO:00828510.6DPT, FGF2, ADAMTS1, TGFB1I1, TGFB1
4positive regulation of endothelial cell proliferationGO:00193810.6BMP6, FGF2, THBS4
5cellular response to dexamethasone stimulusGO:07154910.5TGFB1, AGTR2
6nitric oxide mediated signal transductionGO:00726310.5CD36, AGTR2
7kidney developmentGO:00182210.4ADAMTS1, DCN, BMP6
8hyaluronan catabolic processGO:03021410.4FGF2, TGFB1
9hematopoietic progenitor cell differentiationGO:00224410.1TGFB1, FST

Molecular functions related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4TGFB1, THBS4, FGF2, BMP6

Products for genes affiliated with Hypertrophic Scars

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  • Antibodies
  • Proteins
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Sources for Hypertrophic Scars

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet