MCID: HYP457
MIFTS: 48

Hypertrophic Scars malady

Skin diseases category

Summaries for Hypertrophic Scars

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

MalaCards: Hypertrophic Scars, also known as scars hypertrophic, is related to systemic scleroderma and burn scar. An important gene associated with Hypertrophic Scars is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are p70S6K Signaling and Malaria. The compounds procollagen and benzylamide have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Hypertrophic Scars

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Sources:
32MalaCards, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypertrophic scars 32
scars hypertrophic 44


External Ids:

ICD1025 L91.0

Related Diseases for Hypertrophic Scars

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17GeneCards, 18GeneDecks
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Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1systemic scleroderma30.0BMP6, DCN, CD36, TGFB1
2burn scar10.7
3burns10.7
4scar contracture10.4
5ehlers-danlos syndrome type viib10.2
6type vi ehlers-danlos syndrome10.1
7epidermolysis bullosa dystrophica, ar10.1
8diabetic foot ulcers10.0
9breast reconstruction10.0
10retinopathy of prematurity10.0
11limited scleroderma10.0
12menkes disease10.0
13rubinstein-taybi syndrome10.0
14porphyria cutanea tarda10.0
15epidermolysis bullosa simplex10.0
16leber congenital amaurosis10.0
17type i ehlers-danlos syndrome10.0
18epidermolysis bullosa acquisita10.0
19folliculitis10.0
20mixed connective tissue disease10.0
21oculocerebrorenal syndrome10.0
22cleft lip10.0
23osteopoikilosis10.0
24chickenpox10.0
25lipoid proteinosis10.0
26epidermolysis bullosa dystrophica10.0
27laryngotracheitis10.0
28basal cell carcinoma10.0
29impetigo10.0
30neurofibroma10.0
31obesity10.0
32turner syndrome10.0
33ehlers-danlos syndrome, hypermobility type10.0
34ehlers-danlos syndrome type iv10.0
35kindler syndrome10.0
36cockayne syndrome type ii10.0
37occipital horn syndrome10.0
38ehlers-danlos syndrome dermatosparaxis type10.0
39epidermolysis bullosa simplex, dowling-meara type10.0
40epidermolysis bullosa, pretibial10.0
41varicella virus antenatal infection10.0
42quinquaud's decalvans folliculitis10.0
43torticollis keloids cryptorchidism renal dysplasia10.0
44supraumbilical midabdominal raphe and facial cavernous hemangiomas10.0
45ulerythema ophryogenesis10.0
46loeys-dietz syndrome type 1a10.0
47mandibuloacral dysplasia with type b lipodystrophy10.0
48pemphigus vulgaris10.0
49recessive dystrophic epidermolysis bullosa, generalized, other10.0
50epidermolysis bullosa dystrophica, ad10.0

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to hypertrophic scars

Clinical Features for Hypertrophic Scars

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Drugs & Therapeutics for Hypertrophic Scars

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypertrophic Scars

Search CenterWatch for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

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Anatomical Context for Hypertrophic Scars

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32MalaCards
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MalaCards organs/tissues related to Hypertrophic Scars:

32
Skin, Endothelial, Breast

Animal Models for Hypertrophic Scars or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypertrophic Scars:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6TGFB1, DCN, AGTR2, MAPK7, CD36, FST
2MP:000536910.6DCN, AGTR2, CD36, FGF2, FST, THBS4
3MP:001077110.5DCN, AGTR2, FST, KRT16, KRT14, TGFB1
4MP:000537510.4DPT, CD36, ADAMTS1, TGFB1, AGTR2
5MP:000537610.4DCN, AGTR2, MAPK7, CD36, FGF2, FST
6MP:000538410.4CD36, MAPK7, AGTR2, DCN, FGF2, MMP28
7MP:000539110.3DCN, DPT, CD36, FGF2, FST, KRT14
8MP:000537810.1BMP6, DCN, AGTR2, MAPK7, CD36, FST

Publications for Hypertrophic Scars

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50PubMed
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Articles related to Hypertrophic Scars:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Nonablative fractional laser resurfacing for the treatment of hypertrophic scars: a randomized controlled trial. (23279702)
2013
2
Decreased tissue and serum expression of galectin-7 in patients with hypertrophic scars. (23493985)
2013
3
German S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids). (22937806)
2012
4
Analysis of the binding domain of hydroxypyruvate isomerase homologues in hypertrophic scar fibroblasts]. (22490543)
2012
5
Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression. (21946856)
2012
6
Standard guidelines of care: Keloids and hypertrophic scars. (21220896)
2011
7
New treatment regimen for hypertrophic scars. (22180110)
2011
8
Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. (20662038)
2010
9
The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model: a new strategy for the treatment of hypertrophic scars. (20973868)
2010
10
Resume normal structure of epidermis and prevent hypertrophic scars formation. (19692187)
2010
11
Efficacy of topical cyanoacrylates compared to topical silicone gel in the treatment of hypertrophic scars. (20668330)
2010
12
Effect of recombinant Sp1 gene on the collagen expression of hypertrophic scar fibroblasts in vitro]. (19408726)
2009
13
The effect of tunicamycin on Fas protein expression and its function in fibroblasts from hypertrophic scar and keloid]. (19803206)
2009
14
Histologic analysis of keloids and hypertrophic scars. (19131731)
2009
15
Deep dermal fibroblasts contribute to hypertrophic scarring. (18955978)
2008
16
Prevention and management of hypertrophic scars and keloids after burns in children. (18650721)
2008
17
Effectiveness of mugwort lotion for the treatment of post-burn hypertrophic scars. (18033748)
2008
18
An open-label pilot study to evaluate the efficacy and tolerability of a silicone gel in the treatment of hypertrophic scars using clinical and ultrasound assessments. (18273725)
2008
19
Pressure therapy with a round rod for hypertrophic scars: reply. (18301013)
2008
20
Effect of transfection of recombinant human endothelial nitric oxide synthase gene on hypertrophic scar fibroblasts in vitro]. (19102984)
2008
21
Treatment of keloids and hypertrophic scars using bleom. (18254811)
2008
22
Audit of reactions to topical silicon used in the management of hypertrophic scars. (16782279)
2006
23
Effect of asiaticoside on the expression of transforming growth factor-beta mRNA and matrix metalloproteinases in hypertrophic scars]. (16495179)
2006
24
Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury. (16542140)
2006
25
Non-operative treatment of hypertrophic scars and keloids after burns in children. (21991030)
2006
26
Treatment of hypertrophic scars and keloids with a radiofrequency device: a study of collagen effects. (16365887)
2005
27
The influence of adrenaline on the expression of TGF-beta1, bFGF and I procollagen for hypertrophic scar]. (16463783)
2005
28
Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars. (16040405)
2005
29
Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. (15086768)
2004
30
Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. (14521263)
2003
31
In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. (12950636)
2003
32
The characteristics of PCNA expression in hypertrophic scars and chronic ulcers and implication of the expression]. (12382578)
2002
33
Current developments and uses of cryosurgery in the treatment of keloids and hypertrophic scars. (12028522)
2002
34
Problems associated with the use of silicone gel sheeting for hypertrophic scars in the hot climate of Saudi Arabia. (11451605)
2001
35
Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. (11685189)
2001
36
Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars. (11400150)
2001
37
Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair]. (12516473)
2000
38
Self-adhesive silicone gel sheet: a treatment for hypertrophic scars and keloids. (10808705)
2000
39
Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. (10233760)
1999
40
Topical putrescine (fibrostat) in treatment of hypertrophic scars: phase II study. (8773706)
1996
41
Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. (7604635)
1995
42
A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. (8113473)
1994
43
Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. (1638291)
1992
44
Implants of keloid and hypertrophic scars into the athymic nude mouse: changes in the glycosaminoglycans of the implants. (1905609)
1991
45
Use of nude (athymic) mice for the study of hypertrophic scars and keloids: vascular continuity between mouse and implants. (2817436)
1989
46
A semi-rigid transparent face mask in the treatment of postburn hypertrophic scars. (4052718)
1985
47
A treatment for hypertrophic scars. (6667197)
1983
48
Hypertrophic scars and keloids: a review and new concept concerning their origin. (7184146)
1982
49
Compression treatment of hypertrophic scars in burned children. (719572)
1978
50
Hypertrophic scars and keloids. (856531)
1977

Genetic Variations for Hypertrophic Scars

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Expression for genes affiliated with Hypertrophic Scars

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for genes affiliated with Hypertrophic Scars

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 55SinoBiological
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Compounds for genes affiliated with Hypertrophic Scars

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1procollagen4410.9P4HTM, TGFB1
2benzylamide4410.9TGFB1, FGF2, CD36
3estrogen4410.9DGKQ
4alginate4410.9TGFB1, FGF2, CD36, DCN
5pge24410.9TGFB1
6hydroxyproline44 11 2412.9TGFB1, CD36, P4HTM, DCN, BMP6
7chondroitin sulfate44 2411.9BMP6, DCN, CD36, FGF2, ADAMTS1
8glycosaminoglycan4410.9BMP6, DCN, CD36, FGF2, TGFB1
9heparin44 28 11 2413.8BMP6, DCN, CD36, THBS4, ADAMTS1
10dermatan sulfate4410.8BMP6, DCN, CD36, FGF2
11hyaluronic acid44 2411.8BMP6, DCN, CD36, FGF2, TGFB1
12tgf beta14410.8TGFB1, BMP6, DCN, CD36, FGF2, FST
13paraffin4410.8DCN, CD36, FGF2, KRT16, KRT14, TGFB1
14sodium dodecylsulfate4410.8DGKQ, BMP6, DCN, FGF2, FST, KRT16
15losartan44 49 28 1113.8TGFB1, CD36, AGTR2, BMP6
16calcitriol44 59 11 2413.8BMP6, CD36, FGF2, KRT16, TGFB1
17bromodeoxyuridine4410.8BMP6, FGF2, FST, KRT14, TGFB1
18pirfenidone44 5911.8TGFB1, CD36, BMP6
19serine4410.8DGKQ, MAPK7, FGF2, THBS4, KRT16, KRT14
20bleomycin44 1111.8BMP6, DCN, FGF2, TGFB1
21vitamin e succinate4410.8TGFB1, FGF2, BMP6
22matrigel4410.8BMP6, DCN, CD36, FGF2, TGFB1
23l-ascorbic acid 2-phosphate4410.8TGFB1, CD36
24retinoic acid44 2411.8BMP6, DCN, CD36, FGF2, FST, KRT16
25hydrocortisone44 2 59 1113.8KRT14, FGF2, CD36, BMP6
26creatinine4410.8BMP6, DCN, AGTR2, CD36, FST, TGFB1
27troglitazone44 28 59 1113.8BMP6, CD36, KRT14, TGFB1
28tyrosine4410.8DGKQ, AGTR2, MAPK7, FST, THBS4, KRT14
29halofuginone4410.8CD36, BMP6
30alanine4410.8BMP6, DCN, AGTR2, FGF2, THBS4, KRT14
31ang ii4410.8TGFB1, CD36, AGTR2
32pd 98,0594410.7BMP6, DCN, MAPK7, FGF2, TGFB1
33dihydrotestosterone44 28 11 2413.7TGFB1, FST, FGF2, BMP6
34cmdb74410.7TGFB1, FGF2
35h2o24410.7DGKQ, BMP6, MAPK7, CD36, FGF2, TGFB1I1
36genistein44 28 59 2 11 2415.7DCN, MAPK7, CD36, FGF2, FST
37dexamethasone44 49 28 1113.7BMP6, DCN, FGF2, FST, TGFB1
38cyclosporin a44 28 5912.7BMP6, DCN, AGTR2, FGF2, TGFB1
39vitamin a44 11 2412.7FGF2, FST, KRT16, KRT14
40vegf4410.7BMP6, DCN, CD36, FGF2, FST, TGFB1
41nitric oxide44 11 2412.6DGKQ, BMP6, DCN, AGTR2, FST, KRT16
4215-deoxy-delta-12,14-prostaglandin j24410.6FGF2, CD36, BMP6
43thymidine44 2411.6BMP6, FGF2, FST, ADAMTS1, TGFB1
44tranilast4410.6BMP6, TGFB1
45ribonucleic acid4410.5TGFB1, FST, DCN, BMP6
46pd12331944 2811.5AGTR2, CD36
47sb 20358044 5911.4TGFB1, FGF2, CD36, BMP6
48vitamin d4410.4TGFB1, KRT14, CD36, BMP6
49tamoxifen44 49 28 1113.3DGKQ, KRT14, TGFB1
50polysaccharide4410.2DCN

GO Terms for genes affiliated with Hypertrophic Scars

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16Gene Ontology
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Cellular components related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4DCN, DPT, FGF2, THBS4, TGFB1, BMP6
2extracellular matrixGO:03101210.1TGFB1I1, THBS4, DPT, DCN

Biological processes related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood vessel endothelial cell migrationGO:04353710.7TGFB1, FGF2, AGTR2
2positive regulation of cell divisionGO:05178110.6TGFB1, THBS4, FGF2
3negative regulation of cell proliferationGO:00828510.6DPT, FGF2, ADAMTS1, TGFB1I1, TGFB1
4positive regulation of endothelial cell proliferationGO:00193810.6BMP6, FGF2, THBS4
5cellular response to dexamethasone stimulusGO:07154910.5TGFB1, AGTR2
6nitric oxide mediated signal transductionGO:00726310.5CD36, AGTR2
7kidney developmentGO:00182210.4ADAMTS1, DCN, BMP6
8hyaluronan catabolic processGO:03021410.4FGF2, TGFB1
9hematopoietic progenitor cell differentiationGO:00224410.1TGFB1, FST

Molecular functions related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4TGFB1, THBS4, FGF2, BMP6

Products for genes affiliated with Hypertrophic Scars

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  • Antibodies
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Sources for Hypertrophic Scars

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet