MCID: HYP457
MIFTS: 48

Hypertrophic Scars

Categories: Skin diseases

Aliases & Classifications for Hypertrophic Scars

MalaCards integrated aliases for Hypertrophic Scars:

Name: Hypertrophic Scars 38
Scars Hypertrophic 51

Classifications:



External Ids:

ICD10 32 L91.0

Summaries for Hypertrophic Scars

MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to scleroderma, familial progressive and keloids. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Silicon and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 72 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

Related Diseases for Hypertrophic Scars

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 scleroderma, familial progressive 30.2 BMP6 CD36
2 keloids 30.0 CD36 SMAD2 SMAD3 TGFB1 TGFB3
3 epidermolysis bullosa dystrophica, pretibial 11.0
4 desmoid tumor 10.9
5 burns 10.5
6 osteochondrosis 10.3 CD36 TGFB1
7 cholecystolithiasis 10.3 BMP6 TGFB1
8 melorheostosis 10.3 BMP6 SMAD2
9 osteofibrous dysplasia 10.3 CD36 TGFB1
10 dupuytren contracture 10.3 BMP6 TGFB1
11 peyronie disease 10.2 SMAD3 TGFB1
12 ocular cicatricial pemphigoid 10.2 CD36 TGFB1
13 scar contracture 10.2
14 odontogenic myxoma 10.2 CD36 MMP2
15 gingival disease 10.1 TGFB1 TIMP1
16 diffuse pulmonary fibrosis 10.1 SMAD2 TIMP1
17 clear cell adenocarcinoma 10.1 SMAD2 SMAD3
18 hypertensive heart disease 10.1 CD36 MMP2
19 blood group, i system 10.0
20 endotheliitis 10.0
21 crouzon syndrome 10.0 BMP6 TGFB1
22 fibromatosis, gingival, 1 10.0 CD36 MMP2 TGFB1
23 conjunctival nevus 10.0 MMP2 TIMP1
24 penile disease 10.0 SMAD2 SMAD3 TGFB1
25 burn scar 10.0
26 conjunctivochalasis 10.0 MMP2 TIMP1
27 ureteral disease 10.0 SMAD2 SMAD3 TGFB1
28 microcystic meningioma 10.0 MMP2 TIMP1
29 urinary tract obstruction 10.0 SMAD2 SMAD3 TGFB1
30 sorsby fundus dystrophy 10.0 MMP2 TIMP1
31 nasal cavity squamous cell carcinoma 10.0 MMP2 TIMP1
32 localized scleroderma 10.0 BMP6 SMAD3 TGFB1
33 lung giant cell carcinoma 10.0 MMP2 TIMP1
34 marfan syndrome 9.9 BMP6 CD36 MMP2
35 episodic pain syndrome, familial, 1 9.9
36 gingival overgrowth 9.9 CD36 TGFB1 TIMP1
37 aortic aneurysm, familial thoracic 1 9.9 MMP2 SMAD3
38 myelofibrosis 9.9 BMP6 TGFB1 TIMP1
39 keloid formation 9.8
40 galactorrhea 9.8
41 juvenile nasopharyngeal angiofibroma 9.8 BMP6 TGFB3
42 oral submucous fibrosis 9.8 MMP2 TGFB1 TIMP1
43 pulmonary fibrosis 9.8 SMAD3 TGFB1 TIMP1
44 osteoarthritis 9.8 SMAD3 TGFB1 TIMP1
45 tuberculoid leprosy 9.7 BMP6 TGFB1 TGFB3
46 exudative vitreoretinopathy 1 9.7
47 fibrosis of extraocular muscles, congenital, 1 9.7
48 buschke-ollendorff syndrome 9.7
49 body mass index quantitative trait locus 11 9.7
50 body mass index quantitative trait locus 9 9.7

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars

Symptoms & Phenotypes for Hypertrophic Scars

MGI Mouse Phenotypes related to Hypertrophic Scars:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 KRT16 SMAD3 MMP2 TGFB1 SMAD2 BMP6
2 cardiovascular system MP:0005385 10.05 SMAD3 MMP2 TGFB1 SMAD2 CD36 TIMP1
3 homeostasis/metabolism MP:0005376 10.01 KRT16 SMAD3 MMP2 SMAD2 CD36 TGFB3
4 hematopoietic system MP:0005397 9.98 SMAD3 MMP2 SMAD2 CD36 TGFB3 TIMP1
5 craniofacial MP:0005382 9.97 KRT16 SMAD3 MMP2 TGFB1 SMAD2 TGFB3
6 digestive/alimentary MP:0005381 9.95 KRT16 SMAD3 TGFB1 SMAD2 CD36 TGFB3
7 mortality/aging MP:0010768 9.92 KRT16 SMAD3 MMP2 SMAD2 CD36 TGFB3
8 immune system MP:0005387 9.91 SMAD3 MMP2 SMAD2 CD36 TGFB3 TIMP1
9 neoplasm MP:0002006 9.65 SMAD3 MMP2 SMAD2 TIMP1 TGFB1
10 skeleton MP:0005390 9.56 MMP2 TGFB1 SMAD2 BMP6 CD36 SMAD3
11 respiratory system MP:0005388 9.55 MMP2 SMAD2 TGFB3 TIMP1 TGFB1
12 vision/eye MP:0005391 9.1 SMAD3 MMP2 TGFB1 SMAD2 CD36 TGFB3

Drugs & Therapeutics for Hypertrophic Scars

Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
2
Clobetasol Approved, Investigational Phase 4 25122-41-2, 25122-46-7 5311051 32798
3
Petrolatum Approved, Investigational Phase 4 8009-03-8
4
Ethanol Approved Phase 4 64-17-5 702
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
10 Tocopherol Approved, Investigational, Nutraceutical Phase 4
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
12
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
13 Micronutrients Phase 4
14 Trace Elements Phase 4
15 glucocorticoids Phase 4,Phase 3
16 Anti-Infective Agents Phase 4,Phase 3,Phase 1
17 Antioxidants Phase 4,Phase 2,Phase 3
18 Protective Agents Phase 4,Phase 2,Phase 3
19 Anti-Inflammatory Agents Phase 4
20 Dermatologic Agents Phase 4
21 Emollients Phase 4,Phase 3
22 Hormone Antagonists Phase 4,Phase 2,Phase 3
23 Hormones Phase 4,Phase 2,Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
25 Anti-Infective Agents, Local Phase 4
26 Central Nervous System Depressants Phase 4
27 Cortisol succinate Phase 4
28 Hydrocortisone 17-butyrate 21-propionate Phase 4
29 Hydrocortisone acetate Phase 4
30 Hydrocortisone-17-butyrate Phase 4
31 Tocopherols Phase 4
32 Tocotrienols Phase 4
33 Vitamins Phase 4
34 Antiemetics Phase 4
35 Antineoplastic Agents, Hormonal Phase 4
36 Autonomic Agents Phase 4
37 Gastrointestinal Agents Phase 4
38 Methylprednisolone acetate Phase 4
39 Methylprednisolone Hemisuccinate Phase 4
40 Neuroprotective Agents Phase 4
41 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
42 Prednisolone acetate Phase 4
43 Prednisolone hemisuccinate Phase 4
44 Prednisolone phosphate Phase 4
45 diuretics Phase 4
46 Natriuretic Agents Phase 4
47 Chlorhexidine gluconate Phase 4
48 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
49
Fusidic Acid Approved, Investigational Phase 3 6990-06-3 3000226
50
Dimethyl sulfoxide Approved, Vet_approved Phase 2, Phase 3 67-68-5 679

Interventional clinical trials:

(show top 50) (show all 71)

# Name Status NCT ID Phase Drugs
1 An Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix) Unknown status NCT01004536 Phase 4
2 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4 0.05% Clobetasol propionate;Petrolatum gel
3 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
4 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
5 1540nm Non Ablative Fractional Laser Treatment of Scars Completed NCT01056211 Phase 4
6 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
7 Prevention and Treatment of Stretch Marks With Stratamark™ Completed NCT03377231 Phase 4
8 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
9 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
10 Silicone Gel to Improve Scar in Microtia Patients Recruiting NCT02518035 Phase 4 Silicone Gel
11 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
12 Effectivity of Dermatix in Promoting Scar Maturation Unknown status NCT00548210 Phase 3
13 DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction Unknown status NCT02206477 Phase 2, Phase 3 Dimethyl Sulfoxide;Saline 0.9%
14 Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients Completed NCT03376620 Phase 3 1,4-Diaminobutane;10% Urea cream
15 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
16 Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection Completed NCT02886988 Phase 2, Phase 3 Botulinum toxin type A;normal saline
17 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
18 Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Completed NCT01383187 Phase 2, Phase 3
19 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Recruiting NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
20 Botulinum Toxin to Improve Results in Epicanthoplasty Recruiting NCT03294382 Phase 3 Botulinum toxin type A;Placebo
21 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Recruiting NCT03038594 Phase 2, Phase 3 Somatropin;0.09% Saline Solution
22 The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair Enrolling by invitation NCT03219580 Phase 3 5-Fluorouracil;Normal Saline Flush, 0.9% Injectable Solution
23 Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3 interferon alpha 2b
24 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
25 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults Completed NCT02030275 Phase 2 RXI-109;Placebo
26 Hypertrophic Scarring After Facial Burn Completed NCT00242970 Phase 2
27 Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery Completed NCT01730339 Phase 2 PF-06473871;PF-06473871
28 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
29 Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001 Completed NCT01494922 Phase 2 EXC 001 (currently called PF-06473871)
30 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
31 A Randomized Study to Evaluate the Safety and Efficacy of Various Doses of STP705 in Subjects With Hypertrophic Scar Recruiting NCT02956317 Phase 1, Phase 2 STP705;Placebo
32 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars Active, not recruiting NCT02246465 Phase 2 RXI-109
33 A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study Terminated NCT02205476 Phase 2 PF-06473871;PF-06473871
34 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
35 Juvista (Avotermin) in Breast Reduction Surgery Scars Terminated NCT00432328 Phase 2 Avotermin
36 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
37 Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Unknown status NCT01858038 Phase 1
38 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
39 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
40 Hypertrophic Scar Prevention by Novel Topical Gel Application Not yet recruiting NCT03403621 Phase 1 Pentamidine Isethionate;Silicone Gels
41 Study to Investigate the Pharmacokinetics, Safety, and Tolerability of BMT101 in Healthy Male Volunteers Not yet recruiting NCT03133130 Phase 1 BMT101;Placebo
42 To Study Gene Expression of Postburn Hypertrophic Scar Unknown status NCT01676168
43 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004
44 The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial Unknown status NCT02168634 Botulinum Toxins;Placebo
45 Laser Therapy for Treating Hypertrophic Burn Scars in Children Unknown status NCT01653691
46 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969
47 A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach Unknown status NCT01726907
48 Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study Unknown status NCT01633515
49 Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars Completed NCT02063243
50 Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars Completed NCT01994616

Search NIH Clinical Center for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

MalaCards organs/tissues related to Hypertrophic Scars:

38
Skin, Breast, Liver, Endothelial

Publications for Hypertrophic Scars

Articles related to Hypertrophic Scars:

(show top 50) (show all 573)
# Title Authors Year
1
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
2
MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. ( 29434768 )
2018
3
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
4
Comparison of the effectiveness of pulsed dye laser vs pulsed dye laser combined with ultrapulse fractional CO<sub>2</sub>laser in the treatment of immature red hypertrophic scars. ( 29392869 )
2018
5
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
6
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
7
Current Therapeutic Approach to Hypertrophic Scars. ( 28676850 )
2017
8
Role of Hyaluronidase in the Treatment of Hypertrophic Scars. ( 29140867 )
2017
9
Evaluating accuracy and reliability of active stereophotogrammetry using MAVIS III Wound Camera for three-dimensional assessment of hypertrophic scars. ( 28363664 )
2017
10
Heterotopic Ossification and Hypertrophic Scars. ( 28888300 )
2017
11
Pleiotropic FTY720 Is a Specific and Potent Therapy for Hypertrophic Scars. ( 28288846 )
2017
12
Beta adrenergic receptor blockers reduce the occurrence of keloids and hypertrophic scars after cardiac device implantation: a single-institution case-control study. ( 28092339 )
2017
13
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
14
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. ( 28287424 )
2017
15
Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. ( 29056521 )
2017
16
Laser Modulation of Hypertrophic Scars: Technique and Practice. ( 28888301 )
2017
17
Small Molecular TGF-I^1-Inhibitor-Loaded Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars. ( 28875694 )
2017
18
Hypertrophic Scars: Are Vitamins and Inflammatory Biomarkers Related with the Pathophysiology of Wound Healing? ( 28569361 )
2017
19
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
20
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 28654594 )
2017
21
Review of Silicone Gel Sheeting and Silicone Gel for the Prevention of Hypertrophic Scars and Keloids. ( 28570253 )
2017
22
Biocompatible 5-Aminolevulinic Acid/Au Nanoparticle-Loaded Ethosomal Vesicles for In Vitro Transdermal Synergistic Photodynamic/Photothermal Therapy of Hypertrophic Scars. ( 29247361 )
2017
23
Clinical efficacy of utilizing Ultrapulse CO<sub>2</sub>combined with fractional CO<sub>2</sub>laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation. ( 29058830 )
2017
24
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017
25
MicroRNAa89185 regulates transforming growth factora89I^1 and collagena891 in hypertrophic scar fibroblasts. ( 28259900 )
2017
26
Evidence of invasive and non-invasive treatment modalities for hypertrophic scars: A systematic review. ( 28056485 )
2017
27
Assessing blood flow, microvasculature, erythema and redness in hypertrophic scars: A cross sectional study showing different features that require precise definitions. ( 28153584 )
2017
28
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( 28009689 )
2017
29
FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression. ( 28362515 )
2017
30
MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1. ( 28629444 )
2017
31
Assessment of intralesional injection of botulinum toxin type A injection for hypertrophic scars. ( 27088929 )
2016
32
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. ( 26962683 )
2016
33
Comparison between Stromal Vascular Fraction and Adipose Mesenchymal Stem Cells in Remodeling Hypertrophic Scars. ( 27227960 )
2016
34
Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound, and transepidermal drug delivery. ( 26967960 )
2016
35
Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. ( 26891034 )
2016
36
Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. ( 27207739 )
2016
37
5-Aminolevulinic acid loaded ethosomal vesicles with high entrapment efficiency for in vitro topical transdermal delivery and photodynamic therapy of hypertrophic scars. ( 27830857 )
2016
38
Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts. ( 27207585 )
2016
39
Advances in scar management: prevention and management of hypertrophic scars and keloids. ( 27163611 )
2016
40
5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Comprehensive Review of the Literature. ( 27105629 )
2016
41
Assessment of intralesional injection of botulinum toxin type A injection for hypertrophic scars. ( 26765126 )
2016
42
Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy. ( 27180789 )
2016
43
Topical Silicone Sheet Application in the Treatment of Hypertrophic Scars and Keloids. ( 27847546 )
2016
44
Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. ( 24802644 )
2016
45
The molecular basis of hypertrophic scars. ( 27574672 )
2016
46
Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders. ( 27959277 )
2016
47
Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring. ( 26872063 )
2016
48
The Incidence of Hypertrophic Scarring and Keloid Formation Following Laser Tattoo Removal with a Quality-switched Nd:YAG Laser. ( 27386045 )
2016
49
Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial. ( 26735516 )
2016
50
Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( 27427423 )
2016

Variations for Hypertrophic Scars

Expression for Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for Hypertrophic Scars

Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
2
Show member pathways
13.56 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
3
Show member pathways
13.4 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
4
Show member pathways
13.36 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
5
Show member pathways
13.16 BMP6 SMAD3 TGFB1 TGFB3 TIMP1
6
Show member pathways
12.92 BMP6 TGFB1 TGFB3 TIMP1
7
Show member pathways
12.91 SMAD2 SMAD3 TGFB1 TGFB3
8
Show member pathways
12.91 BMP6 TGFB1 TGFB3 TIMP1
9 12.7 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
10
Show member pathways
12.66 SMAD2 SMAD3 TGFB1 TGFB3
11
Show member pathways
12.64 MMP2 TGFB1 TGFB3 TIMP1
12
Show member pathways
12.6 BMP6 TGFB1 TGFB3 TIMP1
13
Show member pathways
12.5 SMAD2 SMAD3 TGFB1 TGFB3
14
Show member pathways
12.48 MMP2 SMAD2 SMAD3 TGFB1
15
Show member pathways
12.45 SMAD2 SMAD3 TGFB1 TGFB3
16
Show member pathways
12.38 SMAD2 SMAD3 TGFB1 TGFB3
17 12.32 SMAD2 SMAD3 TGFB1 TGFB3
18 12.26 SMAD2 SMAD3 TGFB1 TGFB3
19 12.2 MMP2 SMAD2 TGFB1
20
Show member pathways
12.19 SMAD2 SMAD3 TGFB1
21
Show member pathways
12.12 SMAD2 SMAD3 TGFB1
22 12.11 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
23 12.08 SMAD2 SMAD3 TGFB1 TGFB3
24
Show member pathways
12.05 SMAD2 SMAD3 TGFB1 TGFB3
25
Show member pathways
12.04 MMP2 SMAD3 TGFB1
26 12.02 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
27
Show member pathways
12 SMAD2 SMAD3 TGFB1 TGFB3
28 11.98 SMAD2 SMAD3 TGFB1
29 11.95 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
30 11.89 CD36 MMP2 TGFB1 TIMP1
31 11.83 BMP6 TGFB1 TGFB3
32
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
33 11.79 SMAD2 SMAD3 TGFB1 TGFB3
34
Show member pathways
11.75 SMAD2 SMAD3 TGFB1 TGFB3
35 11.72 MMP2 TGFB1 TGFB3 TIMP1
36
Show member pathways
11.71 SMAD2 SMAD3 TGFB1
37 11.68 SMAD2 SMAD3 TGFB1
38
Show member pathways
11.65 SMAD2 SMAD3 TGFB1
39 11.62 MMP2 SMAD2 SMAD3
40 11.62 CD36 TGFB1 TGFB3
41 11.59 MMP2 TGFB1 TIMP1
42 11.55 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
43 11.54 SMAD2 SMAD3 TGFB1
44 11.46 CD36 TGFB1 TGFB3
45 11.44 SMAD2 SMAD3 TGFB1 TGFB3
46
Show member pathways
11.41 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
47
Show member pathways
11.28 TGFB1 TGFB3
48 11.28 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
49 11.24 MMP2 TGFB1
50 11.22 CD36 MMP2

GO Terms for Hypertrophic Scars

Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 BMP6 CD36 MMP2 TGFB1 TGFB3 TIMP1
2 extracellular matrix GO:0031012 9.56 MMP2 TGFB1 TGFB3 TIMP1
3 SMAD protein complex GO:0071141 9.16 SMAD2 SMAD3
4 platelet alpha granule lumen GO:0031093 9.13 TGFB1 TGFB3 TIMP1
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.99 BMP6 TGFB1 TGFB3 TIMP1
2 negative regulation of cell proliferation GO:0008285 9.98 SMAD2 SMAD3 TGFB1 TGFB3
3 positive regulation of gene expression GO:0010628 9.98 CD36 SMAD2 SMAD3 TGFB1
4 negative regulation of gene expression GO:0010629 9.89 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.89 SMAD2 SMAD3 TGFB3
6 aging GO:0007568 9.88 KRT16 TGFB1 TGFB3 TIMP1
7 response to hypoxia GO:0001666 9.88 MMP2 SMAD3 TGFB1 TGFB3
8 BMP signaling pathway GO:0030509 9.83 BMP6 TGFB1 TGFB3
9 platelet degranulation GO:0002576 9.81 CD36 TGFB1 TGFB3 TIMP1
10 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 BMP6 TGFB1 TGFB3
11 ureteric bud development GO:0001657 9.77 SMAD2 SMAD3 TGFB1
12 positive regulation of protein secretion GO:0050714 9.77 BMP6 TGFB1 TGFB3
13 transforming growth factor beta receptor signaling pathway GO:0007179 9.76 SMAD2 SMAD3 TGFB1 TGFB3
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 CD36 SMAD3
15 extrinsic apoptotic signaling pathway GO:0097191 9.73 SMAD3 TGFB1
16 response to progesterone GO:0032570 9.73 TGFB1 TGFB3
17 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
18 gastrulation GO:0007369 9.73 SMAD2 SMAD3
19 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
20 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 SMAD2 SMAD3 TGFB1 TGFB3
21 digestive tract development GO:0048565 9.72 TGFB1 TGFB3
22 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
23 negative regulation of mitotic cell cycle GO:0045930 9.72 SMAD3 TGFB1
24 developmental growth GO:0048589 9.72 SMAD2 SMAD3
25 cell growth GO:0016049 9.71 TGFB1 TGFB3
26 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
27 positive regulation of collagen biosynthetic process GO:0032967 9.71 TGFB1 TGFB3
28 face morphogenesis GO:0060325 9.71 MMP2 TGFB1 TGFB3
29 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.7 SMAD3 TGFB1
30 signal transduction involved in regulation of gene expression GO:0023019 9.7 SMAD2 SMAD3
31 positive regulation of chondrocyte differentiation GO:0032332 9.7 BMP6 SMAD3
32 negative regulation of DNA replication GO:0008156 9.7 TGFB1 TGFB3
33 endoderm development GO:0007492 9.7 SMAD2 SMAD3 TGFB1
34 activin receptor signaling pathway GO:0032924 9.69 SMAD2 SMAD3
35 cell activation GO:0001775 9.69 TGFB1 TIMP1
36 lens fiber cell differentiation GO:0070306 9.68 SMAD3 TGFB1
37 response to cholesterol GO:0070723 9.67 SMAD2 TGFB1
38 salivary gland morphogenesis GO:0007435 9.67 TGFB1 TGFB3
39 primary miRNA processing GO:0031053 9.67 SMAD2 SMAD3
40 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
41 positive regulation of epithelial to mesenchymal transition GO:0010718 9.67 SMAD2 SMAD3 TGFB1 TGFB3
42 embryonic foregut morphogenesis GO:0048617 9.66 SMAD2 SMAD3
43 pericardium development GO:0060039 9.66 SMAD2 SMAD3
44 response to laminar fluid shear stress GO:0034616 9.65 TGFB1 TGFB3
45 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.65 SMAD2 SMAD3 TGFB1
46 nodal signaling pathway GO:0038092 9.64 SMAD2 SMAD3
47 common-partner SMAD protein phosphorylation GO:0007182 9.64 SMAD2 TGFB1
48 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
49 negative regulation of macrophage cytokine production GO:0010936 9.63 TGFB1 TGFB3
50 positive regulation of extracellular matrix assembly GO:1901203 9.62 SMAD3 TGFB1

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.72 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
2 cytokine activity GO:0005125 9.67 BMP6 TGFB1 TGFB3 TIMP1
3 R-SMAD binding GO:0070412 9.52 SMAD2 SMAD3
4 transforming growth factor beta binding GO:0050431 9.51 CD36 TGFB3
5 enhancer binding GO:0035326 9.49 SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.48 SMAD2 SMAD3
7 primary miRNA binding GO:0070878 9.46 SMAD2 SMAD3
8 growth factor activity GO:0008083 9.46 BMP6 TGFB1 TGFB3 TIMP1
9 type II transforming growth factor beta receptor binding GO:0005114 9.43 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD2 SMAD3
11 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 TGFB1 TGFB3
13 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 SMAD2 SMAD3 TGFB1 TGFB3

Sources for Hypertrophic Scars

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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