MCID: HYP457
MIFTS: 46

Hypertrophic Scars malady

Skin category

Summaries for Hypertrophic Scars

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64Wikipedia, 33MalaCards
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Wikipedia:64 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

MalaCards: Hypertrophic Scars, also known as scars hypertrophic, is related to keloids and systemic scleroderma. An important gene associated with Hypertrophic Scars is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are p70S6K Signaling and Malaria. The compounds procollagen and benzylamide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Hypertrophic Scars

Sources:
33MalaCards, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

hypertrophic scars 33
scars hypertrophic 45


External Ids:

ICD1025 L91.0

Related Diseases for Hypertrophic Scars

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1keloids31.7BMP6, DCN, CD36, FGF2, KRT14, TGFB1
2systemic scleroderma30.0BMP6, DCN, CD36, TGFB1
3burn scar10.8
4scar contracture10.4
5burns10.4
6ehlers-danlos syndrome type viib10.3
7type vi ehlers-danlos syndrome10.2
8epidermolysis bullosa dystrophica, ar10.2
9diabetic foot ulcers10.0
10breast reconstruction10.0
11limited scleroderma10.0
12menkes disease10.0
13rubinstein-taybi syndrome10.0
14porphyria cutanea tarda10.0
15epidermolysis bullosa simplex10.0
16leber congenital amaurosis10.0
17type i ehlers-danlos syndrome10.0
18epidermolysis bullosa acquisita10.0
19folliculitis10.0
20mixed connective tissue disease10.0
21oculocerebrorenal syndrome10.0
22osteopoikilosis10.0
23chickenpox10.0
24lipoid proteinosis10.0
25epidermolysis bullosa dystrophica10.0
26basal cell carcinoma10.0
27turner syndrome10.0
28ehlers-danlos syndrome, hypermobility type10.0
29ehlers-danlos syndrome type iv10.0
30buschke ollendorff syndrome10.0
31kindler syndrome10.0
32cockayne syndrome type ii10.0
33occipital horn syndrome10.0
34ehlers-danlos syndrome dermatosparaxis type10.0
35epidermolysis bullosa simplex, dowling-meara type10.0
36epidermolysis bullosa, pretibial10.0
37varicella virus antenatal infection10.0
38quinquaud's decalvans folliculitis10.0
39torticollis keloids cryptorchidism renal dysplasia10.0
40supraumbilical midabdominal raphe and facial cavernous hemangiomas10.0
41ulerythema ophryogenesis10.0
42loeys-dietz syndrome type 1a10.0
43mandibuloacral dysplasia with type b lipodystrophy10.0
44pemphigus vulgaris10.0
45recessive dystrophic epidermolysis bullosa, generalized, other10.0
46epidermolysis bullosa dystrophica, ad10.0
47epidermolysis bullosa pruriginosa10.0
48ehlers-danlos syndrome, progeroid type, 110.0
49focal facial dermal dysplasia 410.0
50melorheostosis with osteopoikilosis10.0

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to hypertrophic scars

Clinical Features for Hypertrophic Scars

Drugs & Therapeutics for Hypertrophic Scars

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hypertrophic Scars

Drug clinical trials:

Search ClinicalTrials for Hypertrophic Scars

Search NIH Clinical Center for Hypertrophic Scars

Search CenterWatch for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypertrophic Scars:

33
Skin, T cells, B cells

Animal Models for Hypertrophic Scars or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypertrophic Scars

Sources:
51PubMed
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Articles related to Hypertrophic Scars:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Decreased tissue and serum expression of galectin-7 in patients with hypertrophic scars. (23493985)
2013
2
Treatment of keloids and hypertrophic scars with bleomycin and electroporation. (24076710)
2013
3
Post-burn hypertrophic scars are characterized by high levels of IL-1I^ mRNA and protein and TNF-I+ type I receptors. (22226222)
2012
4
Laser and intense pulsed light therapy for the treatment of hypertrophic scars: a systematic review. (21711337)
2011
5
A modification of the Hynes procedure--a surgical innovation in the treatment of mature hypertrophic scars in children. (21596480)
2011
6
New treatment regimen for hypertrophic scars. (22180110)
2011
7
An evaluation of evidence regarding application of silicone gel sheeting for the management of hypertrophic scars and keloids. (21103316)
2010
8
Evaluating tamoxifen effect in the prevention of hypertrophic scars following surgical incisions. (20384746)
2010
9
Efficacy and safety of 1064-nm Q-switched Nd:YAG laser with low fluence for keloids and hypertrophic scars. (20158584)
2010
10
The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review. (20179490)
2010
11
The effect of angiotensin II on phosphoinositide-3 kinase/Akt cascade in cultured fibroblasts derived from patients with hypertrophic scars]. (20432929)
2010
12
The efficacy of silicone gel for the treatment of hypertrophic scars and keloids. (20808600)
2009
13
Basic fibroblast growth factor: a potential new therapeutic tool for the treatment of hypertrophic and keloid scars. (19071002)
2009
14
Preliminary report on the effect of cyanoacrylates on the maturation process of hypertrophic scars. (19076908)
2008
15
Animal models of keloids and hypertrophic scars. (19065711)
2008
16
Effectiveness of mugwort lotion for the treatment of post-burn hypertrophic scars. (18033748)
2008
17
Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars. (17539964)
2007
18
Role of angiotensin II receptors in proliferation of fibroblast derived from human hypertrophic scars]. (17393691)
2007
19
32P-patch contact brachyradiotherapy in the management of recalcitrant keloids and hypertrophic scars. (17921616)
2007
20
The use of collagen-glycosaminoglycan copolymer (Integra) for the repair of hypertrophic scars and keloids. (16679913)
2006
21
Safety and efficacy of local administration of contractubex to hypertrophic scars in comparison to corticosteroid treatment. Results of a multicenter, comparative epidemiological cohort study in Germany. (16634531)
2006
22
Treatment of keloids and hypertrophic scars. (16394352)
2005
23
Postburn galactorrhea with refractory hypertrophic scars: role of obesity under scrutiny. (14610425)
2003
24
Intralesional cryotherapy for enhancing the involution of hypertrophic scars and keloids. (12711943)
2003
25
Hypertrophic scars and keloids: etiology and management. (12680802)
2003
26
Problems associated with the use of silicone gel sheeting for hypertrophic scars in the hot climate of Saudi Arabia. (11451605)
2001
27
Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. (10744070)
2000
28
Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair]. (12516473)
2000
29
From the literature: intralesional 5-FU in the treatment of hypertrophic scars and keloids: clinical experience. (10727318)
2000
30
Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. (10550323)
1999
31
Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings. (9063511)
1996
32
Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. (7591421)
1995
33
Keloid and hypertrophic scars: trace element alteration. (8748214)
1995
34
A quantitative ultrastructural study of collagen fibrils in human skin, normal scars, and hypertrophic scars. (8535965)
1995
35
Normal and hypertrophic scars: quantification and localization of messenger RNAs for type I, III and VI collagens. (8186109)
1994
36
Improvement of erythematous and hypertrophic scars by the 585-nm flashlamp-pumped pulsed dye laser. (8192370)
1994
37
Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series. (8363398)
1993
38
Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. (1638291)
1992
39
The microvessels in hypertrophic scars, keloids and related lesions: a review. (1600518)
1992
40
Surgical notes. Dermabrasion and hypertrophic scars. (1938074)
1991
41
Single-dose electron beam irradiation in treatment and prevention of keloids and hypertrophic scars. (2126387)
1990
42
Why does topical silicone gel improve hypertrophic scars? A hypothesis. (2360183)
1990
43
Some thoughts on hypertrophic scars. (3200956)
1988
44
The use of plastic face mask and silicone gloves and boots as alternative to compression suits for treating hypertrophic scars. (4060893)
1985
45
Our routine in pressure treatment of hypertrophic scars. (6740255)
1984
46
The histochemistry of glycosaminoglycans within hypertrophic scars. (6153738)
1980
47
Microvasculature in hypertrophic scars and the effects of pressure. (490690)
1979
48
Compression treatment of hypertrophic scars in burned children. (719572)
1978
49
Mast cell analyses in hypertrophic scars, hypertrophic scars treated with pressure and mature scars. (649983)
1978
50
Follow-up on treatment of hypertrophic scars and keloids with triamcinolone. (5566476)
1971

Genetic Variations for Hypertrophic Scars

Expression for genes affiliated with Hypertrophic Scars

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for genes affiliated with Hypertrophic Scars

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome, 56SinoBiological
See all sources

Compounds for genes affiliated with Hypertrophic Scars

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1procollagen4510.9P4HTM, TGFB1
2benzylamide4510.9TGFB1, FGF2, CD36
3estrogen4510.9DGKQ
4alginate4510.9TGFB1, FGF2, CD36, DCN
5pge24510.9TGFB1
6hydroxyproline45 11 2412.9TGFB1, CD36, P4HTM, DCN, BMP6
7chondroitin sulfate45 2411.9BMP6, DCN, CD36, FGF2, ADAMTS1
8glycosaminoglycan4510.9BMP6, DCN, CD36, FGF2, TGFB1
9heparin45 29 11 2413.8BMP6, DCN, CD36, THBS4, ADAMTS1
10dermatan sulfate4510.8BMP6, DCN, CD36, FGF2
11hyaluronic acid45 2411.8BMP6, DCN, CD36, FGF2, TGFB1
12tgf beta14510.8TGFB1, BMP6, DCN, CD36, FGF2, FST
13paraffin4510.8DCN, CD36, FGF2, KRT16, KRT14, TGFB1
14sodium dodecylsulfate4510.8DGKQ, BMP6, DCN, FGF2, FST, KRT16
15losartan45 50 29 1113.8TGFB1, CD36, AGTR2, BMP6
16calcitriol45 60 11 2413.8BMP6, CD36, FGF2, KRT16, TGFB1
17bromodeoxyuridine4510.8BMP6, FGF2, FST, KRT14, TGFB1
18pirfenidone45 6011.8TGFB1, CD36, BMP6
19serine4510.8DGKQ, MAPK7, FGF2, THBS4, KRT16, KRT14
20bleomycin45 1111.8BMP6, DCN, FGF2, TGFB1
21vitamin e succinate4510.8TGFB1, FGF2, BMP6
22matrigel4510.8BMP6, DCN, CD36, FGF2, TGFB1
23l-ascorbic acid 2-phosphate4510.8TGFB1, CD36
24retinoic acid45 2411.8BMP6, DCN, CD36, FGF2, FST, KRT16
25hydrocortisone45 2 60 1113.8KRT14, FGF2, CD36, BMP6
26creatinine4510.8BMP6, DCN, AGTR2, CD36, FST, TGFB1
27troglitazone45 29 60 1113.8BMP6, CD36, KRT14, TGFB1
28tyrosine4510.8DGKQ, AGTR2, MAPK7, FST, THBS4, KRT14
29halofuginone4510.8CD36, BMP6
30alanine4510.8BMP6, DCN, AGTR2, FGF2, THBS4, KRT14
31ang ii4510.8TGFB1, CD36, AGTR2
32pd 98,0594510.7BMP6, DCN, MAPK7, FGF2, TGFB1
33dihydrotestosterone45 29 11 2413.7TGFB1, FST, FGF2, BMP6
34cmdb74510.7TGFB1, FGF2
35h2o24510.7DGKQ, BMP6, MAPK7, CD36, FGF2, TGFB1I1
36genistein45 29 60 2 11 2415.7DCN, MAPK7, CD36, FGF2, FST
37dexamethasone45 50 29 1113.7BMP6, DCN, FGF2, FST, TGFB1
38cyclosporin a45 29 6012.7BMP6, DCN, AGTR2, FGF2, TGFB1
39vitamin a45 11 2412.7FGF2, FST, KRT16, KRT14
40vegf4510.7BMP6, DCN, CD36, FGF2, FST, TGFB1
41nitric oxide45 11 2412.6DGKQ, BMP6, DCN, AGTR2, FST, KRT16
4215-deoxy-delta-12,14-prostaglandin j24510.6FGF2, CD36, BMP6
43thymidine45 2411.6BMP6, FGF2, FST, ADAMTS1, TGFB1
44tranilast4510.6BMP6, TGFB1
45ribonucleic acid4510.5TGFB1, FST, DCN, BMP6
46pd12331945 2911.5AGTR2, CD36
47sb 20358045 6011.4TGFB1, FGF2, CD36, BMP6
48vitamin d4510.4TGFB1, KRT14, CD36, BMP6
49tamoxifen45 50 29 1113.3DGKQ, KRT14, TGFB1
50polysaccharide4510.2DCN

GO Terms for genes affiliated with Hypertrophic Scars

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4DCN, DPT, FGF2, THBS4, TGFB1, BMP6
2extracellular matrixGO:03101210.1TGFB1I1, THBS4, DPT, DCN

Biological processes related to Hypertrophic Scars according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood vessel endothelial cell migrationGO:04353710.7TGFB1, FGF2, AGTR2
2positive regulation of cell divisionGO:05178110.6TGFB1, THBS4, FGF2
3negative regulation of cell proliferationGO:00828510.6DPT, FGF2, ADAMTS1, TGFB1I1, TGFB1
4positive regulation of endothelial cell proliferationGO:00193810.6BMP6, FGF2, THBS4
5cellular response to dexamethasone stimulusGO:07154910.5TGFB1, AGTR2
6nitric oxide mediated signal transductionGO:00726310.5CD36, AGTR2
7kidney developmentGO:00182210.4ADAMTS1, DCN, BMP6
8hyaluronan catabolic processGO:03021410.4FGF2, TGFB1
9hematopoietic progenitor cell differentiationGO:00224410.1TGFB1, FST

Molecular functions related to Hypertrophic Scars according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4TGFB1, THBS4, FGF2, BMP6

Products for genes affiliated with Hypertrophic Scars

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypertrophic Scars

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet