MCID: HYP457
MIFTS: 45

Hypertrophic Scars malady

Categories: Skin diseases

Aliases & Classifications for Hypertrophic Scars

Aliases & Descriptions for Hypertrophic Scars:

Name: Hypertrophic Scars 39
Scars Hypertrophic 52

Classifications:



External Ids:

ICD10 33 L91.0

Summaries for Hypertrophic Scars

MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to epidermolysis bullosa, pretibial and keloids. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. The drugs Ethanol and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and breast, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 71 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

Related Diseases for Hypertrophic Scars

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa, pretibial 10.9
2 keloids 10.8
3 burns 10.4
4 akinetic mutism 10.2 CD36 SMAD2
5 anhidrosis 10.2 BMP6 TGFB1
6 ovarian insufficiency, familial 10.1 CD36 TGFB1
7 ovarian insufficiency due to fsh resistance 10.1 CD36 TGFB1
8 scar contracture 10.1
9 noonan syndrome 4 10.0 CD36 MMP2 TGFB1
10 pulmonary valve insufficiency 10.0 SMAD2 SMAD3 TGFB1
11 acute necrotizing encephalitis 10.0 SMAD2 SMAD3 TGFB1
12 hereditary night blindness 10.0 BMP6 SMAD3 TGFB1
13 angiomyoma 10.0 MMP2 TIMP1
14 mass syndrome 10.0 BMP6 MMP2 TGFB1
15 appendix carcinoid tumor 10.0 MMP2 TIMP1
16 germ cell and embryonal cancer 10.0 CD36 TGFB1 TIMP1
17 schwannomatosis 10.0 MMP2 TIMP1
18 striated muscle rhabdoid tumor 10.0 MMP2 TIMP1
19 onychocytic matricoma 10.0 CD36 MMP2
20 upper respiratory tract disease 10.0 SMAD2 TGFB1
21 maxillary neoplasm 10.0 MMP2 TIMP1
22 endotheliitis 10.0
23 breast papillary carcinoma 10.0 MMP2 TIMP1
24 neuromyelitis optica 10.0 BMP6 TGFB1 TIMP1
25 intellectual developmental disorder with persistence of fetal hemoglobin 10.0 SMAD3 TGFB3
26 esophageal neuroendocrine tumor 9.9 MMP2 TGFB1 TIMP1
27 adenoid squamous cell carcinoma 9.9 MMP2 TIMP1
28 burn scar 9.9
29 renal tubular acidosis 9.9 SMAD3 TGFB1 TIMP1
30 discharging ear 9.9 BMP6 TGFB1 TGFB3
31 osteonecrosis 9.9 SMAD3 TGFB1 TIMP1
32 lubani-al saleh-teebi syndrome 9.9 SMAD3 TGFB1 TGFB3
33 endemic typhus 9.9 SMAD3 TGFB1 TGFB3
34 central nervous system teratoma 9.8 MMP2 SMAD3 TIMP1
35 zika fever 9.8 CD36 MMP2 TGFB1 TIMP1
36 neuroectodermal endocrine syndrome 9.8 SMAD2 SMAD3 TGFB1 TIMP1
37 keloid formation 9.8
38 hemorrhagic cystitis 9.8 BMP6 CD36 SMAD2 SMAD3 TGFB1
39 vibratory urticaria 9.7 SMAD2 SMAD3 TGFB1 TGFB3
40 albright's hereditary osteodystrophy 9.7 CD36 SMAD2 SMAD3 TGFB3
41 folliculitis 9.6
42 impetigo 9.6
43 chickenpox 9.6
44 lichen planus 9.6
45 cleft lip 9.6
46 obesity 9.6
47 neurofibroma 9.6
48 buschke-ollendorff syndrome 9.6
49 breast reconstruction 9.6
50 argyria 9.6

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars

Symptoms & Phenotypes for Hypertrophic Scars

MGI Mouse Phenotypes related to Hypertrophic Scars:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 BMP6 CD36 KRT16 MMP2 SMAD2 SMAD3
2 cardiovascular system MP:0005385 10.05 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
3 homeostasis/metabolism MP:0005376 10.01 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4 hematopoietic system MP:0005397 9.98 MMP2 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
5 craniofacial MP:0005382 9.97 KRT16 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
6 digestive/alimentary MP:0005381 9.95 TGFB1 TGFB3 CD36 KRT16 SMAD2 SMAD3
7 mortality/aging MP:0010768 9.92 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
8 immune system MP:0005387 9.91 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
9 neoplasm MP:0002006 9.65 MMP2 SMAD2 SMAD3 TGFB1 TIMP1
10 skeleton MP:0005390 9.56 BMP6 CD36 MMP2 SMAD2 SMAD3 TGFB1
11 respiratory system MP:0005388 9.55 MMP2 SMAD2 TGFB1 TGFB3 TIMP1
12 vision/eye MP:0005391 9.1 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Hypertrophic Scars

Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
7
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
8
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
9
Petrolatum Approved Phase 4 8009-03-8
10
Allopurinol Approved Phase 4 315-30-0 2094
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
12
Butyric Acid Experimental Phase 4 107-92-6 264
13
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
14
Silicon Phase 4 7440-21-3 4082203
15 glucocorticoids Phase 4,Phase 3
16 Trace Elements Phase 4
17 Anti-Infective Agents Phase 4,Phase 3
18 Micronutrients Phase 4
19 Chlorhexidine gluconate Phase 4
20 Prednisolone acetate Phase 4
21
Clobetasol Phase 4 25122-46-7 32798 5311051
22 diuretics Phase 4
23 Natriuretic Agents Phase 4
24 Gastrointestinal Agents Phase 4
25 Neuroprotective Agents Phase 4
26 Cortisol succinate Phase 4
27 Tocopherols Phase 4
28 Tocotrienols Phase 4
29 Dermatologic Agents Phase 4,Phase 1
30 Hormone Antagonists Phase 4,Phase 2,Phase 3
31 Hormones Phase 4,Phase 2,Phase 3
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
34 Emollients Phase 4,Phase 3
35 Hydrocortisone 17-butyrate 21-propionate Phase 4
36 Hydrocortisone acetate Phase 4
37 Hydrocortisone-17-butyrate Phase 4
38 Vitamins Phase 4
39 Prednisolone hemisuccinate Phase 4
40 Prednisolone phosphate Phase 4
41 Protective Agents Phase 4,Phase 2,Phase 3
42 Anti-Infective Agents, Local Phase 4
43 Antiemetics Phase 4
44 Anti-Inflammatory Agents Phase 4,Phase 2
45 Methylprednisolone acetate Phase 4
46 Methylprednisolone Hemisuccinate Phase 4
47 Antirheumatic Agents Phase 4,Phase 2
48 Autonomic Agents Phase 4
49 Antineoplastic Agents, Hormonal Phase 4
50 Antioxidants Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 104)
id Name Status NCT ID Phase
1 An Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix) Unknown status NCT01004536 Phase 4
2 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4
3 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4
4 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
5 1540nm Non Ablative Fractional Laser Treatment of Scars Completed NCT01056211 Phase 4
6 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4
7 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
8 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
9 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
10 Treatment of Facial Burns With Flammacerium Compared to Flammazine and the Impact of Facial Burns on Psychosocial Wellbeing Completed NCT00297752 Phase 4
11 Silicone Gel to Improve Scar in Microtia Patients Recruiting NCT02518035 Phase 4
12 Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension? Active, not recruiting NCT02237339 Phase 4
13 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3
14 Effectivity of Dermatix in Promoting Scar Maturation Unknown status NCT00548210 Phase 3
15 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
16 Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Completed NCT01383187 Phase 2, Phase 3
17 Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection Recruiting NCT02886988 Phase 2, Phase 3
18 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Recruiting NCT01861119 Phase 3
19 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Recruiting NCT03038594 Phase 2, Phase 3
20 DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction Not yet recruiting NCT02206477 Phase 2, Phase 3
21 Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3
22 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
23 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults Completed NCT02030275 Phase 2
24 Hypertrophic Scarring After Facial Burn Completed NCT00242970 Phase 2
25 Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery Completed NCT01730339 Phase 2
26 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
27 Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001 Completed NCT01494922 Phase 2
28 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
29 Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery Completed NCT01346969 Phase 2
30 Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy Completed NCT01150461 Phase 2
31 Pirfenidone to Treat Hypertrophic Cardiomyopathy Completed NCT00011076 Phase 2
32 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars Active, not recruiting NCT02246465 Phase 2
33 A Randomized Study to Evaluate the Safety and Efficacy of Various Doses of STP705 in Subjects With Hypertrophic Scar Not yet recruiting NCT02956317 Phase 1, Phase 2
34 Imaging Assessment of Diastolic Function Not yet recruiting NCT01668264 Phase 2
35 A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study Terminated NCT02205476 Phase 2
36 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2
37 Juvista (Avotermin) in Breast Reduction Surgery Scars Terminated NCT00432328 Phase 2
38 Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis Terminated NCT01230918 Phase 2
39 Feasibility Study of Radiofrequency Heating of Cardiac Infarction Scar to Treat Heart Failure Terminated NCT00881777 Phase 1, Phase 2
40 ACCS (Amnion-derived Cellular Cytokine Solution) Versus Standard Care In Treating Partial Thickness Burns Terminated NCT00886470 Phase 1, Phase 2
41 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
42 Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Unknown status NCT01858038 Phase 1
43 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
44 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1
45 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
46 Study to Investigate the Pharmacokinetics, Safety, and Tolerability of BMT101 in Healthy Male Volunteers Not yet recruiting NCT03133130 Phase 1
47 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004
48 To Study Gene Expression of Postburn Hypertrophic Scar Unknown status NCT01676168
49 Laser Therapy for Treating Hypertrophic Burn Scars in Children Unknown status NCT01653691
50 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969

Search NIH Clinical Center for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

MalaCards organs/tissues related to Hypertrophic Scars:

39
Skin, Endothelial, Breast

Publications for Hypertrophic Scars

Articles related to Hypertrophic Scars:

(show top 50) (show all 544)
id Title Authors Year
1
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017
2
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( 28009689 )
2017
3
Evidence of invasive and non-invasive treatment modalities for hypertrophic scars: A systematic review. ( 28056485 )
2017
4
Beta adrenergic receptor blockers reduce the occurrence of keloids and hypertrophic scars after cardiac device implantation: a single-institution case-control study. ( 28092339 )
2017
5
Botulinum Toxin Type A and the Prevention of Hypertrophic Scars on the Maxillofacial Area and Neck: A Meta-Analysis of Randomized Controlled Trials. ( 26985661 )
2016
6
Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial. ( 27812490 )
2016
7
3D-printed transparent facemasks in the treatment of facial hypertrophic scars of young children with burns. ( 28040366 )
2016
8
Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring. ( 26872063 )
2016
9
Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. ( 26566963 )
2016
10
Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. ( 27207739 )
2016
11
Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment. ( 27347634 )
2016
12
Intralesional treatments for hypertrophic scars: comparison among corticosteroid, 5-fluorouracil and botulinum toxin in rabbit ear hypertrophic scar model. ( 27160135 )
2016
13
Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( 27427423 )
2016
14
Assessment of the Combined Efficacy of Needling and the Use of Silicone Gel in the Treatment of C-Section and Other Surgical Hypertrophic Scars and Keloids. ( 27538108 )
2016
15
Assessment of intralesional injection of botulinum toxin type A injection for hypertrophic scars. ( 26765126 )
2016
16
Inhibitory effect of TGF-I^ peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts. ( 26135051 )
2016
17
Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar. ( 26644005 )
2016
18
Abnormalities in the basement membrane structure promote basal keratinocytes in the epidermis of hypertrophic scars to adopt a proliferative phenotype. ( 26986690 )
2016
19
5-Aminolevulinic acid loaded ethosomal vesicles with high entrapment efficiency for in vitro topical transdermal delivery and photodynamic therapy of hypertrophic scars. ( 27830857 )
2016
20
Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy. ( 27180789 )
2016
21
5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Comprehensive Review of the Literature. ( 27105629 )
2016
22
Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars. ( 27419807 )
2016
23
The Long Non-Coding RNA LncRNA8975-1 is Upregulated in Hypertrophic Scar Fibroblasts and Controls Collagen Expression. ( 27866191 )
2016
24
Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging. ( 26763427 )
2016
25
Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression. ( 24802644 )
2016
26
The molecular basis of hypertrophic scars. ( 27574672 )
2016
27
Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars. ( 28001261 )
2016
28
Assessment of intralesional injection of botulinum toxin type A injection for hypertrophic scars. ( 27088929 )
2016
29
Advances in scar management: prevention and management of hypertrophic scars and keloids. ( 27163611 )
2016
30
The Incidence of Hypertrophic Scarring and Keloid Formation Following Laser Tattoo Removal with a Quality-switched Nd:YAG Laser. ( 27386045 )
2016
31
Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial. ( 26735516 )
2016
32
Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. ( 26891034 )
2016
33
Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound, and transepidermal drug delivery. ( 26967960 )
2016
34
Keloids and Hypertrophic Scars: A Spectrum of Clinical Challenges. ( 26894654 )
2016
35
Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications. ( 27636511 )
2016
36
Topical Silicone Sheet Application in the Treatment of Hypertrophic Scars and Keloids. ( 27847546 )
2016
37
Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders. ( 27959277 )
2016
38
Comparison between Stromal Vascular Fraction and Adipose Mesenchymal Stem Cells in Remodeling Hypertrophic Scars. ( 27227960 )
2016
39
Surface biofunctional drug-loaded electrospun fibrous scaffolds for comprehensive repairing hypertrophic scars. ( 26774564 )
2016
40
Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy. ( 26521845 )
2016
41
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. ( 26962683 )
2016
42
Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-I^/Smad signaling in hypertrophic scar fibroblasts. ( 25655281 )
2015
43
miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity. ( 25876136 )
2015
44
Role of verapamil in preventing and treating hypertrophic scars and keloids. ( 25968157 )
2015
45
MRP1 knockdown down-regulates the deposition of collagen and leads to a reduced hypertrophic scar fibrosis. ( 26092470 )
2015
46
Depigmentation and hypertrophic scars after application of a fluid lactic acid tattoo eraser. ( 25962974 )
2015
47
Nd: YAG Laser Treatment for Keloids and Hypertrophic Scars: An Analysis of 102 Cases: Erratum. ( 25973347 )
2015
48
Peroxisome proliferator-activated receptor-I^ (PPAR-I^) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145. ( 25704091 )
2015
49
Treatment of hypertrophic scars and keloids by fractional carbon dioxide laser: a clinical, histological, and immunohistochemical study. ( 26498451 )
2015
50
Mechanism of Action, Efficacy, and Adverse Events of Calcium Antagonists in Hypertrophic Scars and Keloids: A Systematic Review. ( 26606434 )
2015

Variations for Hypertrophic Scars

Expression for Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for Hypertrophic Scars

Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
2
Show member pathways
13.4 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
3
Show member pathways
13.37 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4
Show member pathways
13.16 BMP6 SMAD3 TGFB1 TGFB3 TIMP1
5
Show member pathways
12.9 BMP6 TGFB1 TGFB3 TIMP1
6
Show member pathways
12.79 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.65 MMP2 TGFB1 TGFB3 TIMP1
8
Show member pathways
12.6 BMP6 TGFB1 TGFB3 TIMP1
9 12.58 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
10
Show member pathways
12.51 SMAD2 SMAD3 TGFB1 TGFB3
11
Show member pathways
12.43 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
12
Show member pathways
12.4 SMAD2 SMAD3 TGFB1 TGFB3
13 12.34 SMAD2 SMAD3 TGFB1 TGFB3
14 12.33 SMAD2 SMAD3 TGFB1 TGFB3
15 12.27 SMAD2 SMAD3 TGFB1 TGFB3
16
Show member pathways
12.25 SMAD2 SMAD3 TGFB1 TGFB3
17 12.2 MMP2 SMAD2 TGFB1
18
Show member pathways
12.19 SMAD2 SMAD3 TGFB1
19
Show member pathways
12.12 SMAD2 SMAD3 TGFB1
20 12.09 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
21
Show member pathways
12.03 MMP2 SMAD3 TGFB1
22
Show member pathways
12.02 SMAD2 SMAD3 TGFB1 TGFB3
23
Show member pathways
12.01 SMAD2 SMAD3 TGFB1 TGFB3
24 11.99 SMAD2 SMAD3 TGFB1
25 11.98 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
26 11.91 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
27 11.88 CD36 MMP2 TGFB1 TIMP1
28 11.83 BMP6 TGFB1 TGFB3
29
Show member pathways
11.82 SMAD2 SMAD3 TGFB1 TGFB3
30
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
31 11.8 SMAD2 SMAD3 TGFB1 TGFB3
32
Show member pathways
11.72 SMAD2 SMAD3 TGFB1
33 11.7 MMP2 TGFB1 TGFB3 TIMP1
34 11.68 SMAD2 SMAD3 TGFB1
35 11.66 CD36 TGFB1 TGFB3
36
Show member pathways
11.66 SMAD2 SMAD3 TGFB1
37 11.65 BMP6 TGFB1 TGFB3 TIMP1
38 11.63 MMP2 SMAD2 SMAD3
39 11.59 MMP2 TGFB1 TIMP1
40 11.55 SMAD2 SMAD3 TGFB1
41 11.55 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
42 11.46 CD36 TGFB1 TGFB3
43
Show member pathways
11.41 SMAD2 SMAD3 TGFB1
44 11.41 SMAD2 SMAD3 TGFB1 TGFB3
45
Show member pathways
11.32 TGFB1 TGFB3
46 11.28 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
47 11.26 CD36 MMP2
48 11.24 MMP2 TGFB1
49 11.21 SMAD2 SMAD3
50 11.15 SMAD2 TGFB1 TGFB3

GO Terms for Hypertrophic Scars

Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 BMP6 CD36 MMP2 TGFB1 TGFB3 TIMP1
2 extracellular matrix GO:0031012 9.46 MMP2 TGFB1 TGFB3 TIMP1
3 SMAD protein complex GO:0071141 9.32 SMAD2 SMAD3
4 platelet alpha granule lumen GO:0031093 9.13 TGFB1 TGFB3 TIMP1
5 SMAD2-SMAD3 protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 SMAD2 SMAD3 TGFB1 TGFB3
2 regulation of apoptotic process GO:0042981 9.9 BMP6 TGFB1 TGFB3
3 in utero embryonic development GO:0001701 9.89 SMAD2 SMAD3 TGFB3
4 aging GO:0007568 9.89 KRT16 TGFB1 TGFB3 TIMP1
5 negative regulation of gene expression GO:0010629 9.88 CD36 SMAD2 TGFB1
6 response to hypoxia GO:0001666 9.88 MMP2 SMAD3 TGFB1 TGFB3
7 BMP signaling pathway GO:0030509 9.83 BMP6 TGFB1 TGFB3
8 platelet degranulation GO:0002576 9.81 CD36 TGFB1 TGFB3 TIMP1
9 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 BMP6 TGFB1 TGFB3
10 ureteric bud development GO:0001657 9.77 SMAD2 SMAD3 TGFB1
11 positive regulation of protein secretion GO:0050714 9.76 BMP6 TGFB1 TGFB3
12 wound healing GO:0042060 9.76 SMAD3 TGFB1 TGFB3 TIMP1
13 extrinsic apoptotic signaling pathway GO:0097191 9.73 SMAD3 TGFB1
14 response to progesterone GO:0032570 9.73 TGFB1 TGFB3
15 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
16 transforming growth factor beta receptor signaling pathway GO:0007179 9.73 SMAD2 SMAD3 TGFB1 TGFB3
17 embryonic cranial skeleton morphogenesis GO:0048701 9.72 SMAD2 SMAD3
18 digestive tract development GO:0048565 9.72 TGFB1 TGFB3
19 gastrulation GO:0007369 9.72 SMAD2 SMAD3
20 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
21 developmental growth GO:0048589 9.72 SMAD2 SMAD3
22 negative regulation of mitotic cell cycle GO:0045930 9.71 SMAD3 TGFB1
23 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
24 positive regulation of collagen biosynthetic process GO:0032967 9.71 TGFB1 TGFB3
25 face morphogenesis GO:0060325 9.71 MMP2 TGFB1 TGFB3
26 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.7 SMAD3 TGFB1
27 signal transduction involved in regulation of gene expression GO:0023019 9.7 SMAD2 SMAD3
28 negative regulation of DNA replication GO:0008156 9.7 TGFB1 TGFB3
29 endoderm development GO:0007492 9.7 SMAD2 SMAD3 TGFB1
30 positive regulation of chondrocyte differentiation GO:0032332 9.69 BMP6 SMAD3
31 activin receptor signaling pathway GO:0032924 9.69 SMAD2 SMAD3
32 cell activation GO:0001775 9.68 TGFB1 TIMP1
33 lens fiber cell differentiation GO:0070306 9.68 SMAD3 TGFB1
34 salivary gland morphogenesis GO:0007435 9.68 TGFB1 TGFB3
35 embryonic foregut morphogenesis GO:0048617 9.67 SMAD2 SMAD3
36 SMAD protein import into nucleus GO:0007184 9.67 TGFB1 TGFB3
37 response to cholesterol GO:0070723 9.67 SMAD2 TGFB1
38 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
39 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.67 SMAD2 SMAD3 TGFB1 TGFB3
40 primary miRNA processing GO:0031053 9.66 SMAD2 SMAD3
41 pericardium development GO:0060039 9.66 SMAD2 SMAD3
42 response to laminar fluid shear stress GO:0034616 9.65 TGFB1 TGFB3
43 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.65 SMAD2 SMAD3 TGFB1
44 nodal signaling pathway GO:0038092 9.64 SMAD2 SMAD3
45 common-partner SMAD protein phosphorylation GO:0007182 9.64 SMAD2 TGFB1
46 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
47 negative regulation of macrophage cytokine production GO:0010936 9.63 TGFB1 TGFB3
48 ossification involved in bone remodeling GO:0043932 9.62 TGFB1 TGFB3
49 frontal suture morphogenesis GO:0060364 9.62 TGFB1 TGFB3
50 positive regulation of extracellular matrix assembly GO:1901203 9.61 SMAD3 TGFB1

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 BMP6 TGFB1 TGFB3 TIMP1
2 protein heterodimerization activity GO:0046982 9.65 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
3 R-SMAD binding GO:0070412 9.52 SMAD2 SMAD3
4 transforming growth factor beta binding GO:0050431 9.51 CD36 TGFB3
5 enhancer binding GO:0035326 9.49 SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.48 SMAD2 SMAD3
7 primary miRNA binding GO:0070878 9.46 SMAD2 SMAD3
8 growth factor activity GO:0008083 9.46 BMP6 TGFB1 TGFB3 TIMP1
9 type II transforming growth factor beta receptor binding GO:0005114 9.43 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD2 SMAD3
11 type III transforming growth factor beta receptor binding GO:0034714 9.32 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 TGFB1 TGFB3
13 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 SMAD2 SMAD3 TGFB1 TGFB3

Sources for Hypertrophic Scars

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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37 KEGG
38 LifeMap
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60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
69 UMLS
70 UMLS via Orphanet
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