MCID: HYP047
MIFTS: 35

Hypertropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

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Aliases & Descriptions for Hypertropia:

Name: Hypertropia 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:9837
ICD1027 H50.2
ICD9CM29 378.31
SNOMED-CT59 194109005, 40608009
MeSH36 D013285
NCIt42 C34716
UMLS65 C0020575

Summaries for Hypertropia

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Wikipedia:68 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypertropia is related to partial third-nerve palsy and endometriosis in scar of skin. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and Alzheimers Disease Pathway. Affiliated tissues include eye, breast and endothelial.

Related Diseases for Hypertropia

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Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1partial third-nerve palsy10.6CHN1, KIF21A
2endometriosis in scar of skin10.6CHN1, KIF21A
3total circumpapillary dystrophy of choroid10.5CHN1, KIF21A
4ametropic amblyopia10.5CHN1, KIF21A
5hallucinogen abuse10.5CHN1, KIF21A
6lipid-rich carcinoma10.4CHN1, KIF21A
7breast-ovarian cancer, familial, 210.4CHN1, FOXL2
8exotropia10.2
9fallopian tube clear cell adenocarcinoma10.2FOXL2, LAX1
10meckel syndrome 310.2CHN1, FOXL2, KIF21A
11water-clear cell adenoma10.1CHN1, KIF21A
12hypotropia10.1
13plagiocephaly and x-linked mental retardation10.1FGFR2, FGFR3
14flna-related periventricular nodular heterotopia10.1FGFR2, FGFR3
15bladder cancer, somatic10.1FGFR2, FGFR3
16hypogonadotropic hypogonadism 2 with or without anosmia10.1FGFR2, FGFR3
17gallbladder disease10.1FOXL2, KIF21A
18apert syndrome10.1FGFR2, FGFR3
19poland syndrome10.1FGFR2, FGFR3
20diverticulitis of colon10.1FGFR2, FGFR3
21crouzon syndrome with acanthosis nigricans10.0FGFR2, FGFR3
22thanatophoric dysplasia, type i10.0FGFR2, FGFR3
23antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.0FGFR2, FGFR3
24strabismus10.0
25slc16a1-related hyperinsulinism10.0FGFR2, FGFR3
26beare-stevenson cutis gyrata syndrome9.9FGFR2, FGFR3
27tenosynovial giant cell tumor9.9FGFR2, FGFR3
28septicemic plague9.9LAX1, TTR
29darier disease9.9FGFR3, LAX1
30bone deterioration disease9.8FGFR2, FGFR3
31cataract9.8
32hemangioma9.8
33amblyopia9.8
34synostosis9.8
35retinitis9.8
36intramuscular hemangioma9.8
37retinal detachment9.8
38abducens palsy9.8
39hypochondroplasia9.8FGFR2, FGFR3
40thanatophoric dysplasia, type ii9.7FGFR2, FGFR3
41craniosynostosis, type 19.4FGFR2, FGFR3
42cyclotropia6.7CHN1, FGFR2, FGFR3, FOXL2, FUT3, HTN3

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to hypertropia

Symptoms for Hypertropia

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Drugs & Therapeutics for Hypertropia

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Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Acetylcholineexperimental68951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter Agents14795
3OnabotulinumtoxinA588
4IncobotulinumtoxinA599
5Botulinum Toxins, Type A588
6Botulinum Toxins616
7AbobotulinumtoxinA588
8Cholinergic Agents3243

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Observational Study of Adult StrabismusRecruitingNCT02510040

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

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Anatomical Context for Hypertropia

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MalaCards organs/tissues related to Hypertropia:

33
Eye, Breast, Endothelial, Colon, Skin, Thyroid, Prostate

Animal Models for Hypertropia or affiliated genes

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Publications for Hypertropia

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Articles related to Hypertropia:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Hypertropia in unilateral isolated abducens palsy. (24924275)
2014
2
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? (25477320)
2014
3
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. (24767828)
2014
4
Isolated inferior oblique myectomy for hypertropia. (25603661)
2014
5
Relationship of hypertropia and excyclotorsion in superior oblique palsy. (23372378)
2013
6
Resolution of hypertropia with correction of intermittent exotropia. (23934140)
2013
7
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. (23993717)
2013
8
Inferior oblique transposition for large hypertropia after vertical rectus transposition. (23618631)
2013
9
Hypertropia following Spontaneous Resolution of Brown's Syndrome. (22855678)
2012
10
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. (21057518)
2011
11
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. (20337346)
2010
12
Surgical management of clinically significant hypertropia associated with exotropia. (20603056)
2010
13
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? (19132949)
2008
14
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. (19065984)
2008
15
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. (18670464)
2008
16
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. (17572341)
2007
17
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. (17016462)
2007
18
A case of intramuscular hemangioma presenting with large-angle hypertropia. (17004637)
2006
19
Incidence and types of childhood hypertropia: a population-based study. (16647125)
2006
20
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. (15977869)
2005
21
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. (15314594)
2004
22
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. (15747755)
2004
23
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. (12917609)
2003
24
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. (12067267)
2002
25
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. (11874381)
2002
26
Two entities in which a dissociative hypertropia may present after surgery. (11874375)
2002
27
Monofixation with eso-, exo-, or hypertropia: is there a difference? (21149032)
2001
28
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. (10845415)
2000
29
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. (9852443)
1998
30
Hypertropia and the posterior blowout fracture. (8684811)
1996
31
Ipsilateral hypertropia after cataract surgery. (8637680)
1996
32
Hypertropia and the posterior blowout fracture: Mechanism and management. (8628546)
1996
33
Unilateral congenital fibrosis syndrome presenting with hypertropia. (8154269)
1993
34
Hypertropia following trochlear trauma. (1432500)
1992
35
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. (1286718)
1992
36
Hypertropia after implantation of a Molteno drainage device. (1728155)
1992
37
Alternating skew on lateral gaze (bilateral abducting hypertropia). (3377440)
1988
38
Superior oblique strengthening procedures in hypertropia I and II. (438930)
1979
39
Dissociated hypertropia: surgical treatment. (542245)
1979
40
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. (749595)
1978
41
Treatment of hypertropia by vertical displacement of horizontal recti. (900607)
1977
42
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. (5089863)
1971
43
Alternating hyperphoria and hypertropia. (13991876)
1963
44
Alternating hypertropia. (13744524)
1961
45
Post-inflammatory ectopia of the macula resulting in apparent hypertropia. (13364190)
1956
46
Hypertropia corrected by changes of the lateral rectus insertion. (13182170)
1954
47
The significance of alternating hypertropia in concomitant strabismus. (14923774)
1952
48
Postoperative hypertropia. (18894714)
1948
49
Tenotomy of the superior oblique muscle for hypertropia; preliminary report. (20273126)
1947
50
Tenotomy of the Superior Oblique for Hypertropia: Preliminary Report. (16693420)
1946

Variations for Hypertropia

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Expression for genes affiliated with Hypertropia

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Search GEO for disease gene expression data for Hypertropia.

Pathways for genes affiliated with Hypertropia

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Pathways related to Hypertropia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3FGFR2, FGFR3
29.3FGFR2, FGFR3
3
Show member pathways
9.0CHN1, FGFR2, FGFR3

GO Terms for genes affiliated with Hypertropia

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Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:00105189.7FGFR2, FGFR3
2regulation of phosphatidylinositol 3-kinase signalingGO:00140669.5FGFR2, FGFR3
3phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.5FGFR2, FGFR3
4positive regulation of MAPK cascadeGO:00434109.4FGFR2, FGFR3
5bone mineralizationGO:00302829.3FGFR2, FGFR3
6positive regulation of ERK1 and ERK2 cascadeGO:00703749.2FGFR2, FGFR3
7bone morphogenesisGO:00603499.0FGFR2, FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00050079.3FGFR2, FGFR3

Sources for Hypertropia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet