MCID: HYP047
MIFTS: 28

Hypertropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

Aliases & Descriptions for Hypertropia:

Name: Hypertropia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD10 33 H50.2
ICD9CM 35 378.31
MeSH 42 D013285
NCIt 47 C34716
SNOMED-CT 64 194109005 40608009
UMLS 69 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and endometriosis of ovary. An important gene associated with Hypertropia is CHN1 (Chimerin 1). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 71 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 hypotropia 11.0
2 endometriosis of ovary 10.2 CHN1 KIF21A
3 familial porphyria cutanea tarda 10.2 FGFR2 FGFR3
4 hartsfield syndrome 10.2 FGFR2 FGFR3
5 pointer syndrome 10.2 FGFR2 FGFR3
6 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.2 FGFR2 FGFR3
7 cervical spinal canal and spinal cord meningioma 10.2 FGFR2 FGFR3
8 joubert syndrome 6 10.2 CHN1 FOXL2 KIF21A
9 osteoglophonic dysplasia 10.2 FGFR2 FGFR3
10 tubulointerstitial nephritis with uveitis 10.2 CHN1 TUBB3
11 deep keratitis 10.2 CHN1 SAMHD1
12 febrile seizures, familial, 1 10.1 CHN1 KIF21A TUBB3
13 ulceration of vulva 10.1 CHN1 KIF21A TUBB3
14 mental retardation, autosomal dominant 7 10.1 CHN1 KIF21A TUBB3
15 chronic lacrimal gland enlargement 10.1 CHN1 KIF21A TUBB3
16 infected hydrocele 10.1 CHN1 KANTR
17 exotropia 10.1
18 aica-ribosiduria due to atic deficiency 10.1 FGFR2 FGFR3
19 uterine corpus epithelioid leiomyoma 10.0 SAMHD1 TTR
20 crouzon syndrome with acanthosis nigricans 10.0 FGFR2 FGFR3
21 cellulitis 10.0 LAX1 TTR
22 acute serous otitis media 10.0 CHN1 KANTR
23 fanconi anemia, complementation group d1 10.0 FOXL2 TUBB3
24 acral lentiginous melanoma 10.0 KANTR SAMHD1
25 ampulla of vater adenosquamous carcinoma 10.0 CHN1 KANTR
26 pontocerebellar hypoplasia 10.0 CHN1 FOXL2 KIF21A TUBB3
27 urinary bladder villous adenoma 10.0 CHN1 FGFR2 KIF21A TUBB3
28 nerve fibre bundle defect 10.0 CHN1 KANTR KIF21A
29 anal canal adenocarcinoma 10.0 FOXL2 KANTR
30 right bundle branch block 10.0 KANTR TG
31 alopecia areata 10.0 CHN1 KIF21A SAMHD1 TUBB3
32 muenke syndrome 10.0 FGFR2 FGFR3
33 rheumatic disease 10.0 KANTR LAX1
34 guillain-barre syndrome 9.9 KANTR TG
35 interstitial keratitis 9.9 CHN1 KANTR SAMHD1
36 ancylostomiasis 9.9 KANTR LAX1
37 childhood vagina botryoid rhabdomyosarcoma 9.9 TG TTR TUBB3
38 ulcerative blepharitis 9.9 KANTR TUBB3
39 hallucinogen abuse 9.9 KANTR LAX1
40 tinea profunda 9.9 KANTR LAX1
41 strabismus 9.9
42 uterine ligament serous adenocarcinoma 9.7 CHN1 KANTR TTR TUBB3
43 cataract 9.7
44 hemangioma 9.7
45 amblyopia 9.7
46 synostosis 9.7
47 retinitis 9.7
48 intramuscular hemangioma 9.7
49 retinal detachment 9.7
50 abducens palsy 9.7

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2 Cholinergic Agents
3 Neurotransmitter Agents
4 abobotulinumtoxinA
5 incobotulinumtoxinA
6 onabotulinumtoxinA
7 Botulinum Toxins
8 Botulinum Toxins, Type A

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Prospective Observational Study of Adult Strabismus Recruiting NCT02510040
2 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

39
Eye

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 58)
id Title Authors Year
1
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. ( 27787462 )
2016
2
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. ( 26928363 )
2016
3
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? ( 25477320 )
2014
4
Accuracy of double maddox rod with induced hypertropia in normal subjects. ( 25313115 )
2014
5
Isolated inferior oblique myectomy for hypertropia. ( 25603661 )
2014
6
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. ( 24767828 )
2014
7
Hypertropia in unilateral isolated abducens palsy. ( 24924275 )
2014
8
Relationship of hypertropia and excyclotorsion in superior oblique palsy. ( 23372378 )
2013
9
Inferior oblique transposition for large hypertropia after vertical rectus transposition. ( 23618631 )
2013
10
Resolution of hypertropia with correction of intermittent exotropia. ( 23934140 )
2013
11
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. ( 23993717 )
2013
12
Hypertropia following Spontaneous Resolution of Brown's Syndrome. ( 22855678 )
2012
13
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. ( 21057518 )
2011
14
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. ( 21282574 )
2011
15
Surgical management of clinically significant hypertropia associated with exotropia. ( 20603056 )
2010
16
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. ( 20337346 )
2010
17
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? ( 19132949 )
2008
18
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. ( 19065984 )
2008
19
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. ( 18670464 )
2008
20
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. ( 17572341 )
2007
21
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. ( 17016462 )
2007
22
Incidence and types of childhood hypertropia: a population-based study. ( 16647125 )
2006
23
A case of intramuscular hemangioma presenting with large-angle hypertropia. ( 17004637 )
2006
24
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. ( 16908815 )
2006
25
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. ( 15977869 )
2005
26
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. ( 15747755 )
2004
27
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. ( 15314594 )
2004
28
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. ( 12917609 )
2003
29
Two entities in which a dissociative hypertropia may present after surgery. ( 11874375 )
2002
30
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. ( 11874381 )
2002
31
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. ( 12067267 )
2002
32
Monofixation with eso-, exo-, or hypertropia: is there a difference? ( 21149032 )
2001
33
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. ( 10845415 )
2000
34
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. ( 9852443 )
1998
35
Hypertropia and the posterior blowout fracture. ( 8684811 )
1996
36
Hypertropia and the posterior blowout fracture: Mechanism and management. ( 8628546 )
1996
37
Ipsilateral hypertropia after cataract surgery. ( 8637680 )
1996
38
Unilateral congenital fibrosis syndrome presenting with hypertropia. ( 8154269 )
1993
39
Hypertropia following trochlear trauma. ( 1432500 )
1992
40
Hypertropia after implantation of a Molteno drainage device. ( 1728155 )
1992
41
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. ( 1286718 )
1992
42
Alternating skew on lateral gaze (bilateral abducting hypertropia). ( 3377440 )
1988
43
Superior oblique strengthening procedures in hypertropia I and II. ( 438930 )
1979
44
Dissociated hypertropia: surgical treatment. ( 542245 )
1979
45
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. ( 749595 )
1978
46
Treatment of hypertropia by vertical displacement of horizontal recti. ( 900607 )
1977
47
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. ( 5089863 )
1971
48
Prismatic correction of a large progressive hypertropia. ( 5246998 )
1968
49
Alternating hyperphoria and hypertropia. ( 13991876 )
1963
50
Alternating hypertropia. ( 13744524 )
1961

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 bone mineralization GO:0030282 9.26 FGFR2 FGFR3
2 bone morphogenesis GO:0060349 9.16 FGFR2 FGFR3
3 positive regulation of phospholipase activity GO:0010518 8.96 FGFR2 FGFR3
4 endochondral bone growth GO:0003416 8.62 FGFR2 FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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