MCID: HYP047
MIFTS: 30

Hypertropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

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Aliases & Descriptions for Hypertropia:

Name: Hypertropia 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:9837
ICD1027 H50.2
ICD9CM29 378.31
SNOMED-CT59 194109005, 40608009
MeSH36 D013285
NCIt42 C34716
UMLS65 C0020575

Summaries for Hypertropia

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Wikipedia:68 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypertropia is related to hypotropia and partial third-nerve palsy. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and Alzheimers Disease Pathway. Affiliated tissues include eye, brain and thyroid.

Related Diseases for Hypertropia

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Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1hypotropia10.5
2partial third-nerve palsy10.4CHN1, KIF21A
3endometriosis in scar of skin10.4CHN1, KIF21A
4total circumpapillary dystrophy of choroid10.4CHN1, KIF21A
5ametropic amblyopia10.3CHN1, KIF21A
6hallucinogen abuse10.3CHN1, KIF21A
7lipid-rich carcinoma10.3CHN1, KIF21A
8breast-ovarian cancer, familial, 210.2CHN1, FOXL2
9systemic lupus erythematosus10.2
10ovarian cancer10.2
11lupus erythematosus10.2
12fallopian tube clear cell adenocarcinoma10.1FOXL2, LAX1
13meckel syndrome 310.1CHN1, FOXL2, KIF21A
14water-clear cell adenoma10.1CHN1, KIF21A
15rheumatoid arthritis10.1
16myocardial infarction10.1
17fructose intolerance10.1
18arthritis10.1
19congestive heart failure10.1
20gastric cancer10.1
21hematopoietic stem cell transplantation10.1
22male infertility10.1
23thrombocytopenia10.1
24chikungunya10.1
25brachydactyly10.1
26apraxia10.1
27body dysmorphic disorder10.1
28purpura fulminans10.1
29graves' disease10.1
30breast fibroadenoma10.1
31neuritis10.1
32dysostosis10.1
33thrombocytosis10.1
34purpura10.1
35mutism10.1
36milk allergy10.1
37infertility10.1
38neuronitis10.1
39lung disease10.1
40genital herpes10.1
41fascioliasis10.1
42learning disability10.1
43bacterial meningitis10.1
44meningitis10.1
45fasciitis10.1
46necrotizing fasciitis10.1
47postcholecystectomy syndrome10.1
48phosphorylase kinase deficiency10.1
49cluster headache10.1
50superior vena cava syndrome10.1

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to hypertropia

Symptoms for Hypertropia

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Drugs & Therapeutics for Hypertropia

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Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Acetylcholineexperimental68951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter Agents14795
3OnabotulinumtoxinA588
4IncobotulinumtoxinA599
5Botulinum Toxins, Type A588
6Botulinum Toxins616
7AbobotulinumtoxinA588
8Cholinergic Agents3243

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Observational Study of Adult StrabismusRecruitingNCT02510040

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

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Anatomical Context for Hypertropia

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MalaCards organs/tissues related to Hypertropia:

33
Eye, Brain, Thyroid, Breast, Endothelial, Prostate, Skeletal muscle

Animal Models for Hypertropia or affiliated genes

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Publications for Hypertropia

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Articles related to Hypertropia:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis. (27198559)
2016
2
Glomangiopericytoma and glomus tumor of the sinonasal tract: A report of two cases with emphasis on the differential diagnosis. (26972077)
2016
3
One year in review: the pathogenesis of rheumatoid arthritis. (26203933)
2015
4
What to do when the Diagnosis of Giant Cell Arteritis and Takayasu's Arteritis Overlap. (26223093)
2015
5
Systemic Capillary Leak Syndrome after Influenza Vaccination in a Peritoneal Dialysis Patient. (26703855)
2015
6
Novel inflammatory biomarkers in primary hyperparathyroidism. (25850829)
2015
7
Proteomic analysis of ubiquitin-like posttranslational modifications induced by the adenovirus E4-ORF3 protein. (25410875)
2015
8
Tuberculous optic neuritis: A case report. (25829080)
2015
9
Mortality and its determinants in people with psychotic disorder. (23257931)
2013
10
Risk Factors for Placenta Accreta: A Large Prospective Cohort. (24338130)
2013
11
Anti-miRNA-23a oligonucleotide suppresses glioma cells growth by targeting apoptotic protease activating factor-1. (23865473)
2013
12
Antimicrobial Resistance Pattern in Enterococcus faecalis Strains Isolated From Expressed Prostatic Secretions of Patients With Chronic Bacterial Prostatitis. (23878692)
2013
13
Network analysis of icb-1 gene function in human breast cancer cells. (22565810)
2012
14
Current Status of Endoscopic Stenting of the Pancreatic Duct as Prophylaxis Against Post-ERCP Pancreatitis. (23983649)
2012
15
Comparative analysis of the new chronic kidney disease epidemiology collaboration and the modification of diet in renal disease equations for estimation of glomerular filtration rate in HIV type 1-infected subjects. (21284524)
2011
16
Potential antioxidant, antiinflammatory, and proapoptotic anticancer activities of Kakadu plum and Illawarra plum polyphenolic fractions. (21875324)
2011
17
Expression of CD44V6 in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma. (20374021)
2010
18
Kikuchi disease and thyroid follicular adenoma. (20859864)
2010
19
Discovering disease-specific biomarker genes for cancer diagnosis and prognosis. (20441232)
2010
20
Electrostatic interaction between oxysterol-binding protein and VAMP- associated protein A revealed by NMR and mutagenesis studies. (20178991)
2010
21
Medulloblastoma harbor somatic mitochondrial DNA mutations in the D-loop region. (20147852)
2010
22
Benefit of corticosteroid therapy in Angelman syndrome. (19666884)
2009
23
Pregnancy and lactation after breast cancer elevate plasma prolactin, do not shorten and may prolong survival. (19632054)
2009
24
Wt1 negatively regulates beta-catenin signaling during testis development. (18403409)
2008
25
Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells. (17393199)
2007
26
Adult neurogenesis and the memories of drug addiction. (17401727)
2007
27
Involvement of Rho kinase in endothelial barrier maintenance. (17761936)
2007
28
Study on serum transcobalamin II in patients with murine typhus. (17547071)
2006
29
Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. (15273737)
2004
30
Prevalence of asymmetric exophthalmos in Graves orbitopathy. (15167731)
2004
31
Cdc42 regulates the restoration of endothelial barrier function. (14656933)
2004
32
Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. (12704229)
2003
33
A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect. (12787122)
2003
34
Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral budding. (12244217)
2002
35
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. (11980671)
2002
36
Functional brain activation during arithmetic processing in females with fragile X Syndrome is related to FMR1 protein expression. (12112763)
2002
37
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. (11463390)
2001
38
Characterization of cells collected from the normal human ocular surface by contact lens cytology. (11095058)
2000
39
The C494F variant in the CYP11B1 gene is a sequence polymorphism in the Spanish population. (10599751)
1999
40
Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance. (10458359)
1999
41
Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures. (10526118)
1999
42
Serine-O-sulphate transport by the human glutamate transporter, EAAT2. (9605566)
1998
43
A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type II. (9783710)
1998
44
HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA. (9462708)
1998
45
Can the CD4+/CD8+ ratio predict the outcome of interferon-alpha therapy for renal cell carcinoma? (9093710)
1997
46
Response to methotrexate in a patient with idiopathic eosinophilic fasciitis, morphea, IgM hypergammaglobulinemia, and renal involvement. (8992001)
1995
47
Requirement of the human immunodeficiency virus type 1 env gene sequence for TAR-independent trans activation by Tat from the major immediate-early promoter of murine cytomegalovirus. (8093034)
1994
48
Double outlet left ventricle with intact ventricular septum. (6698644)
1984
49
Letter: Childhood lactose intolerance. (1244515)
1976
50
Genetic aetiology of lactose intolerance. (4165709)
1967

Variations for Hypertropia

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Expression for genes affiliated with Hypertropia

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Search GEO for disease gene expression data for Hypertropia.

Pathways for genes affiliated with Hypertropia

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Pathways related to Hypertropia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3FGFR2, FGFR3
29.3FGFR2, FGFR3
3
Show member pathways
9.0CHN1, FGFR2, FGFR3

GO Terms for genes affiliated with Hypertropia

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Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:00105189.7FGFR2, FGFR3
2regulation of phosphatidylinositol 3-kinase signalingGO:00140669.5FGFR2, FGFR3
3phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.5FGFR2, FGFR3
4positive regulation of MAPK cascadeGO:00434109.4FGFR2, FGFR3
5bone mineralizationGO:00302829.3FGFR2, FGFR3
6positive regulation of ERK1 and ERK2 cascadeGO:00703749.2FGFR2, FGFR3
7bone morphogenesisGO:00603499.0FGFR2, FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00050079.3FGFR2, FGFR3

Sources for Hypertropia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet