MCID: HYP047
MIFTS: 30

Hypertropia

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

MalaCards integrated aliases for Hypertropia:

Name: Hypertropia 12 72 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD10 32 H50.2
ICD9CM 34 378.31
MeSH 41 D013285
NCIt 46 C34716
SNOMED-CT 64 194109005 40608009
UMLS 69 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and exotropia. An important gene associated with Hypertropia is CHN1 (Chimerin 1). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 72 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 hypotropia 31.1 CHN1 KANTR KIF21A SAMHD1 TUBB3
2 exotropia 30.7 CHN1 KIF21A TUBB3
3 strabismus 29.7 CHN1 FGFR2 FGFR3 KIF21A TUBB3
4 plagiocephaly 10.4 FGFR2 FGFR3
5 osteoglophonic dysplasia 10.4 FGFR2 FGFR3
6 luteoma 10.4 FGFR2 FGFR3
7 beare-stevenson cutis gyrata syndrome 10.4 FGFR2 FGFR3
8 marcus gunn phenomenon 10.4 CHN1 TUBB3
9 alternating esotropia 10.3 CHN1 KANTR
10 jackson-weiss syndrome 10.3 FGFR2 FGFR3
11 esotropia 10.3 CHN1 TUBB3
12 moebius syndrome 10.3 FOXL2 TUBB3
13 oculomotor nerve paralysis 10.3 CHN1 KANTR
14 third cranial nerve disease 10.3 CHN1 KANTR
15 congenital ptosis 10.3 CHN1 KIF21A TUBB3
16 deafness, autosomal dominant 28 10.3 CHN1 KIF21A TUBB3
17 tukel syndrome 10.3 CHN1 KIF21A TUBB3
18 ocular motility disease 10.3 CHN1 KIF21A TUBB3
19 duane retraction syndrome 10.2 CHN1 KIF21A TUBB3
20 thanatophoric dysplasia, type i 10.2 FGFR2 FGFR3
21 cerebellopontine angle meningioma 10.2 KANTR SAMHD1
22 brachial plexus neuritis 10.2 FOXL2 KANTR
23 ptosis 10.2 FOXL2 KIF21A TUBB3
24 dental abscess 10.2 ACP5 KANTR
25 bladder neck obstruction 10.2 SAMHD1 TTR
26 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 FGFR2 TG
27 substernal goiter 10.1 KANTR TG
28 thyroid crisis 10.1 KANTR TG
29 accommodative esotropia 10.1 CHN1 KANTR SAMHD1
30 facial paralysis 10.1 KANTR TUBB3
31 facial nerve disease 10.0 KANTR KIF21A TUBB3
32 brown-sequard syndrome 10.0 KANTR TTR
33 spinal canal and spinal cord meningioma 10.0 SAMHD1 TG
34 hydrocephalus 10.0 FGFR2 FGFR3 TTR
35 spinal meningioma 9.9 SAMHD1 TG
36 spastic ectropion 9.9 KANTR LAX1
37 blepharochalasis 9.9 LAX1 TTR
38 cranial nerve disease 9.9 CHN1 KANTR KIF21A TUBB3
39 senile entropion 9.9 KANTR LAX1
40 amyloid tumor 9.9 TG TTR TUBB3
41 cicatricial ectropion 9.9 KANTR LAX1
42 senile ectropion 9.8 KANTR LAX1
43 exposure keratitis 9.8 KANTR TUBB3
44 abducens palsy 9.8
45 fibrosis of extraocular muscles, congenital, 1 9.8
46 retinal detachment 9.8
47 cataract 9.8
48 hemangioma 9.8
49 amblyopia 9.8
50 synostosis 9.8

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2 abobotulinumtoxinA
3 Cholinergic Agents
4 Neurotransmitter Agents
5 onabotulinumtoxinA
6 Botulinum Toxins
7 Botulinum Toxins, Type A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Observational Study of Adult Strabismus Recruiting NCT02510040
2 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

38
Eye

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 61)
# Title Authors Year
1
Inferior Oblique Belly Transposition for Small Angle Hypertropia With Inferior Oblique Overaction: A Pilot Study. ( 28991348 )
2018
2
Treatment of Small Angle Hypertropia With Inferior Oblique Overaction. ( 29378079 )
2018
3
Resolution of hypertropia with correction of consecutive horizontal deviation. ( 28499831 )
2017
4
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. ( 27787462 )
2016
5
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. ( 26928363 )
2016
6
Accuracy of double maddox rod with induced hypertropia in normal subjects. ( 25313115 )
2014
7
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? ( 25477320 )
2014
8
Hypertropia in unilateral isolated abducens palsy. ( 24924275 )
2014
9
Isolated inferior oblique myectomy for hypertropia. ( 25603661 )
2014
10
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. ( 24767828 )
2014
11
Inferior oblique transposition for large hypertropia after vertical rectus transposition. ( 23618631 )
2013
12
Relationship of hypertropia and excyclotorsion in superior oblique palsy. ( 23372378 )
2013
13
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. ( 23993717 )
2013
14
Resolution of hypertropia with correction of intermittent exotropia. ( 23934140 )
2013
15
Hypertropia following Spontaneous Resolution of Brown's Syndrome. ( 22855678 )
2012
16
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. ( 21282574 )
2011
17
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. ( 21057518 )
2011
18
Surgical management of clinically significant hypertropia associated with exotropia. ( 20603056 )
2010
19
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. ( 20337346 )
2010
20
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. ( 18670464 )
2008
21
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. ( 19065984 )
2008
22
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? ( 19132949 )
2008
23
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. ( 17572341 )
2007
24
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. ( 17016462 )
2007
25
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. ( 16908815 )
2006
26
Incidence and types of childhood hypertropia: a population-based study. ( 16647125 )
2006
27
A case of intramuscular hemangioma presenting with large-angle hypertropia. ( 17004637 )
2006
28
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. ( 15977869 )
2005
29
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. ( 15747755 )
2004
30
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. ( 15314594 )
2004
31
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. ( 12917609 )
2003
32
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. ( 12067267 )
2002
33
Two entities in which a dissociative hypertropia may present after surgery. ( 11874375 )
2002
34
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. ( 11874381 )
2002
35
Monofixation with eso-, exo-, or hypertropia: is there a difference? ( 21149032 )
2001
36
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. ( 10845415 )
2000
37
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. ( 9852443 )
1998
38
Hypertropia and the posterior blowout fracture. ( 8684811 )
1996
39
Ipsilateral hypertropia after cataract surgery. ( 8637680 )
1996
40
Hypertropia and the posterior blowout fracture: Mechanism and management. ( 8628546 )
1996
41
Unilateral congenital fibrosis syndrome presenting with hypertropia. ( 8154269 )
1993
42
Hypertropia after implantation of a Molteno drainage device. ( 1728155 )
1992
43
Hypertropia following trochlear trauma. ( 1432500 )
1992
44
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. ( 1286718 )
1992
45
Alternating skew on lateral gaze (bilateral abducting hypertropia). ( 3377440 )
1988
46
Superior oblique strengthening procedures in hypertropia I and II. ( 438930 )
1979
47
Dissociated hypertropia: surgical treatment. ( 542245 )
1979
48
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. ( 749595 )
1978
49
Treatment of hypertropia by vertical displacement of horizontal recti. ( 900607 )
1977
50
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. ( 5089863 )
1971

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inactivation of MAPK activity GO:0000188 9.26 DUSP4 LAX1
2 positive regulation of phospholipase activity GO:0010518 9.16 FGFR2 FGFR3
3 endochondral bone growth GO:0003416 8.96 FGFR2 FGFR3
4 bone morphogenesis GO:0060349 8.8 ACP5 FGFR2 FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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