MCID: HYP047
MIFTS: 31

Hypertropia malady

Neuronal diseases, Eye diseases categories

Aliases & Classifications for Hypertropia

About this section

Aliases & Descriptions for Hypertropia:

Name: Hypertropia 10 12 65
 
Strabismus 36


Classifications:



External Ids:

Disease Ontology10 DOID:9837
ICD9CM29 378.31
SNOMED-CT59 40608009, 194109005
NCIt42 C34716
MeSH36 D013285

Summaries for Hypertropia

About this section
Wikipedia:68 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypertropia, also known as strabismus, is related to crouzon syndrome and moebius syndrome. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and Alzheimers Disease Pathway. Affiliated tissues include eye.

Related Diseases for Hypertropia

About this section

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 780)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.4FGFR2, FGFR3
2moebius syndrome30.3CHN1, FOXL2
3apert syndrome30.3FGFR2, FGFR3
4cyclotropia30.2CHN1, KANTR
5jackson-weiss syndrome30.1FGFR2, FGFR3
6eye disease10.5
7refractive error10.5
8esotropia10.5
9ocular motility disease10.5
10foster-kennedy syndrome10.4
11spiradenoma10.4
12cranial nerve disease10.4
13optic nerve disease10.4
14motor neuro-ophthalmic disorders10.4
15exotropia10.4
16anisometropia10.4
17thyroiditis10.3
18globe disease10.3
19myopia10.3
20ptosis, congenital10.3CHN1, KIF21A
21hemifacial hyperplasia strabismus10.3
22external ear carcinoma10.2CHN1, KIF21A
23paralytic squint10.2
24scleritis10.2
25acute cor pulmonale10.2CHN1, KIF21A
26acute hemorrhagic conjunctivitis10.2CHN1, KIF21A
27amino acid metabolic disorder10.2CHN1, KIF21A
28mental retardation, anterior maxillary protrusion, and strabismus10.2
29ptosis10.2
30ptosis strabismus ectopic pupils10.2
31hypotropia10.2
32strabismus10.2
33duane retraction syndrome10.2
34cellulitis10.2
35mechanical strabismus10.2
36neurologic diseases10.2
37external auditory meatus lipoma10.2CHN1, KANTR
38thoracic benign neoplasm10.2CHN1, KANTR
39ohdo syndrome10.2CHN1, KIF21A
40flna-related periventricular nodular heterotopia10.2FGFR2, FGFR3
41plagiocephaly and x-linked mental retardation10.2FGFR2, FGFR3
42osteoglophonic dysplasia10.2FGFR2, FGFR3
43von economo's disease10.2FGFR2, FGFR3
44muenke syndrome10.2FGFR2, FGFR3
45beare-stevenson cutis gyrata syndrome10.2FGFR2, FGFR3
46orbital cellulitis10.2
47ophthalmoplegia10.2
48neonatal abstinence syndrome10.1FGFR2, FGFR3
49testicular brenner tumor10.1FGFR2, FGFR3
50kidney rhabdoid cancer10.1FOXL2, KANTR

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to hypertropia

Symptoms for Hypertropia

About this section

Drugs & Therapeutics for Hypertropia

About this section

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Botulinum Toxins, Type A561
2Botulinum Toxins590

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Observational Study of Adult StrabismusRecruitingNCT02510040

Search NIH Clinical Center for Hypertropia


Cochrane evidence based reviews: Strabismus

Genetic Tests for Hypertropia

About this section

Anatomical Context for Hypertropia

About this section

MalaCards organs/tissues related to Hypertropia:

33
Eye

Animal Models for Hypertropia or affiliated genes

About this section

Publications for Hypertropia

About this section

Articles related to Hypertropia:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Hypertropia in unilateral isolated abducens palsy. (24924275)
2014
2
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? (25477320)
2014
3
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. (24767828)
2014
4
Isolated inferior oblique myectomy for hypertropia. (25603661)
2014
5
Accuracy of double maddox rod with induced hypertropia in normal subjects. (25313115)
2014
6
Relationship of hypertropia and excyclotorsion in superior oblique palsy. (23372378)
2013
7
Resolution of hypertropia with correction of intermittent exotropia. (23934140)
2013
8
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. (23993717)
2013
9
Inferior oblique transposition for large hypertropia after vertical rectus transposition. (23618631)
2013
10
Hypertropia following Spontaneous Resolution of Brown's Syndrome. (22855678)
2012
11
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. (21057518)
2011
12
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. (20337346)
2010
13
Surgical management of clinically significant hypertropia associated with exotropia. (20603056)
2010
14
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? (19132949)
2008
15
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. (19065984)
2008
16
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. (18670464)
2008
17
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. (17572341)
2007
18
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. (17016462)
2007
19
A case of intramuscular hemangioma presenting with large-angle hypertropia. (17004637)
2006
20
Incidence and types of childhood hypertropia: a population-based study. (16647125)
2006
21
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. (16908815)
2006
22
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. (15977869)
2005
23
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. (15314594)
2004
24
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. (15747755)
2004
25
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. (12917609)
2003
26
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. (12067267)
2002
27
Two entities in which a dissociative hypertropia may present after surgery. (11874375)
2002
28
Monofixation with eso-, exo-, or hypertropia: is there a difference? (21149032)
2001
29
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. (10845415)
2000
30
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. (9852443)
1998
31
Ipsilateral hypertropia after cataract surgery. (8637680)
1996
32
Hypertropia and the posterior blowout fracture: Mechanism and management. (8628546)
1996
33
Unilateral congenital fibrosis syndrome presenting with hypertropia. (8154269)
1993
34
Hypertropia following trochlear trauma. (1432500)
1992
35
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. (1286718)
1992
36
Hypertropia after implantation of a Molteno drainage device. (1728155)
1992
37
Alternating skew on lateral gaze (bilateral abducting hypertropia). (3377440)
1988
38
Superior oblique strengthening procedures in hypertropia I and II. (438930)
1979
39
Dissociated hypertropia: surgical treatment. (542245)
1979
40
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. (749595)
1978
41
Treatment of hypertropia by vertical displacement of horizontal recti. (900607)
1977
42
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. (5089863)
1971
43
Prismatic correction of a large progressive hypertropia. (5246998)
1968
44
Alternating hyperphoria and hypertropia. (13991876)
1963
45
Alternating hypertropia. (13744524)
1961
46
Post-inflammatory ectopia of the macula resulting in apparent hypertropia. (13364190)
1956
47
Hypertropia corrected by changes of the lateral rectus insertion. (13182170)
1954
48
The significance of alternating hypertropia in concomitant strabismus. (14923774)
1952
49
Tenotomy of the superior oblique muscle for hypertropia; preliminary report. (20273126)
1947
50
Tenotomy of the Superior Oblique for Hypertropia: Preliminary Report. (16693420)
1946

Variations for Hypertropia

About this section

Expression for genes affiliated with Hypertropia

About this section
Search GEO for disease gene expression data for Hypertropia.

Pathways for genes affiliated with Hypertropia

About this section

Pathways related to Hypertropia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGFR2, FGFR3
29.6FGFR2, FGFR3
3
Show member pathways
9.3CHN1, FGFR2, FGFR3

GO Terms for genes affiliated with Hypertropia

About this section

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lens fiber cell developmentGO:00703079.8FGFR2, FGFR3
2negative regulation of mitotic nuclear divisionGO:00458399.8FGFR2, FGFR3
3positive regulation of phospholipase activityGO:00105189.7FGFR2, FGFR3
4bone mineralizationGO:00302829.6FGFR2, FGFR3
5bone morphogenesisGO:00603499.3FGFR2, FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00050079.6FGFR2, FGFR3
2fibroblast growth factor bindingGO:00171349.6FGFR2, FGFR3

Sources for Hypertropia

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet