MCID: HYP047
MIFTS: 28

Hypertropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

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Aliases & Descriptions for Hypertropia:

Name: Hypertropia 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:9837
ICD1030 H50.2
ICD9CM32 378.31
SNOMED-CT62 194109005, 40608009
MeSH39 D013285
NCIt45 C34716

Summaries for Hypertropia

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Wikipedia:71 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypertropia is related to hypotropia and endometriosis of rectovaginal septum and vagina. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways is Cytoskeleton remodeling_RalB regulation pathway. Affiliated tissues include eye.

Related Diseases for Hypertropia

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Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1hypotropia31.5CHN1, KANTR, SAMHD1
2endometriosis of rectovaginal septum and vagina10.6CHN1, KIF21A
3flnb-related disorders10.4FGFR2, FGFR3
4plasmalogens synthesis deficiency isolated10.4FGFR2, FGFR3
5trigonocephaly 110.4FGFR2, FGFR3
6adenosquamous breast carcinoma10.4CHN1, KANTR
7mite infestation10.4FGFR2, FGFR3
8bladder cancer, somatic10.4FGFR2, FGFR3
9apert syndrome10.4FGFR2, FGFR3
10meckel syndrome 310.3CHN1, FOXL2, KIF21A
11hypogonadotropic hypogonadism 2 with or without anosmia10.3FGFR2, FGFR3
12central nervous system leukemia10.3FGFR2, FGFR3
13vaginal adenoma10.3CHN1, FGFR2, KIF21A
14brachial plexus neuropathy10.3FOXL2, KANTR
15crouzon syndrome with acanthosis nigricans10.3FGFR2, FGFR3
16mucopolysaccharidosis10.3CHN1, KIF21A
17monofixation syndrome10.2CHN1, KIF21A, SAMHD1
18thanatophoric dysplasia, type i10.2FGFR2, FGFR3
19melanocytic psammomatous mpnst10.2KANTR, SAMHD1
20antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
21scleredema adultorum10.2FGFR2, FGFR3
22lymphoepithelioma-like carcinoma10.2CHN1, KANTR, KIF21A
23b-cell childhood acute lymphoblastic leukemia10.2CHN1, KIF21A
24schistosomiasis10.2SAMHD1, TTR
25abnormal threshold of rods10.1KANTR, TTR
26lesion of sciatic nerve10.1KANTR, TTR
27exotropia10.1
28neurilemmoma of the fifth cranial nerve10.1KANTR, SAMHD1
29ovarian mucinous neoplasm10.1KANTR, TTR
30expressive language disorder10.0SAMHD1, TG
31ancylostomiasis10.0KANTR, TG
32xanthogranulomatous pyelonephritis10.0SAMHD1, TG
33beare-stevenson cutis gyrata syndrome10.0FGFR2, FGFR3
34dysautonomia, familial10.0FGFR2, TG
35bone lymphoma10.0TG, TTR
36idiopathic juvenile osteoporosis10.0CHN1, KIF21A
37apraxia10.0KANTR, SAMHD1
38tinea cruris10.0KANTR, SAMHD1
39uterine ligament clear cell adenocarcinoma10.0FOXL2, LAX1
40communicating hydrocephalus9.9KANTR, LAX1
41prolapse of female genital organ9.9KANTR, LAX1
42ocular motility disease9.9KANTR, LAX1
43reading disorder9.9KANTR, LAX1
44plague9.9LAX1, TTR
45glaucomatocyclitic crisis9.9FGFR2, FGFR3, TG
46strabismus9.9
47abducens nerve disease9.8CHN1, KANTR, KIF21A, SAMHD1
48ovarian cystic teratoma9.8TG, TTR
49cataract9.7
50hemangioma9.7

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to hypertropia

Symptoms & Phenotypes for Hypertropia

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Drugs & Therapeutics for Hypertropia

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Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Acetylcholineapproved77651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter Agents17734
3onabotulinumtoxinA626
4incobotulinumtoxinA635
5Botulinum Toxins, Type A630
6Botulinum Toxins669
7abobotulinumtoxinA626
8Cholinergic Agents3846

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Observational Study of Adult StrabismusRecruitingNCT02510040
2Routine Care Study Evaluating Ocular TorsionNot yet recruitingNCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

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Anatomical Context for Hypertropia

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MalaCards organs/tissues related to Hypertropia:

36
Eye

Publications for Hypertropia

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Articles related to Hypertropia:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. (27787462)
2016
2
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. (26928363)
2016
3
Hypertropia in unilateral isolated abducens palsy. (24924275)
2014
4
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? (25477320)
2014
5
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. (24767828)
2014
6
Isolated inferior oblique myectomy for hypertropia. (25603661)
2014
7
Accuracy of double maddox rod with induced hypertropia in normal subjects. (25313115)
2014
8
Resolution of hypertropia with correction of intermittent exotropia. (23934140)
2013
9
Inferior oblique transposition for large hypertropia after vertical rectus transposition. (23618631)
2013
10
Relationship of hypertropia and excyclotorsion in superior oblique palsy. (23372378)
2013
11
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. (23993717)
2013
12
Hypertropia following Spontaneous Resolution of Brown's Syndrome. (22855678)
2012
13
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. (21282574)
2011
14
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. (21057518)
2011
15
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. (20337346)
2010
16
Surgical management of clinically significant hypertropia associated with exotropia. (20603056)
2010
17
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? (19132949)
2008
18
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. (18670464)
2008
19
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. (19065984)
2008
20
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. (17572341)
2007
21
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. (17016462)
2007
22
Incidence and types of childhood hypertropia: a population-based study. (16647125)
2006
23
A case of intramuscular hemangioma presenting with large-angle hypertropia. (17004637)
2006
24
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. (16908815)
2006
25
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. (15977869)
2005
26
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. (15314594)
2004
27
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. (15747755)
2004
28
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. (12917609)
2003
29
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. (12067267)
2002
30
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. (11874381)
2002
31
Two entities in which a dissociative hypertropia may present after surgery. (11874375)
2002
32
Monofixation with eso-, exo-, or hypertropia: is there a difference? (21149032)
2001
33
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. (10845415)
2000
34
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. (9852443)
1998
35
Hypertropia and the posterior blowout fracture. (8684811)
1996
36
Ipsilateral hypertropia after cataract surgery. (8637680)
1996
37
Hypertropia and the posterior blowout fracture: Mechanism and management. (8628546)
1996
38
Unilateral congenital fibrosis syndrome presenting with hypertropia. (8154269)
1993
39
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. (1286718)
1992
40
Hypertropia following trochlear trauma. (1432500)
1992
41
Hypertropia after implantation of a Molteno drainage device. (1728155)
1992
42
Alternating skew on lateral gaze (bilateral abducting hypertropia). (3377440)
1988
43
Superior oblique strengthening procedures in hypertropia I and II. (438930)
1979
44
Dissociated hypertropia: surgical treatment. (542245)
1979
45
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. (749595)
1978
46
Treatment of hypertropia by vertical displacement of horizontal recti. (900607)
1977
47
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. (5089863)
1971
48
Prismatic correction of a large progressive hypertropia. (5246998)
1968
49
Alternating hyperphoria and hypertropia. (13991876)
1963
50
Alternating hypertropia. (13744524)
1961

Variations for Hypertropia

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Expression for genes affiliated with Hypertropia

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Search GEO for disease gene expression data for Hypertropia.

Pathways for genes affiliated with Hypertropia

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Pathways related to Hypertropia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4CHN1, FGFR2, FGFR3

GO Terms for genes affiliated with Hypertropia

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Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:003028210.1FGFR2, FGFR3
2bone morphogenesisGO:00603499.9FGFR2, FGFR3
3positive regulation of phospholipase activityGO:00105189.7FGFR2, FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:00171349.8FGFR2, FGFR3
2fibroblast growth factor-activated receptor activityGO:00050079.7FGFR2, FGFR3

Sources for Hypertropia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet