MCID: HYP047
MIFTS: 27

Hypertropia

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

MalaCards integrated aliases for Hypertropia:

Name: Hypertropia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD10 33 H50.2
ICD9CM 35 378.31
MeSH 42 D013285
NCIt 47 C34716
SNOMED-CT 64 194109005 40608009
UMLS 69 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and coloboma of macula and skeletal anomalies. An important gene associated with Hypertropia is CHN1 (Chimerin 1). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 72 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 hypotropia 11.0
2 coloboma of macula and skeletal anomalies 10.6 CHN1 TUBB3
3 plasmalogens synthesis deficiency isolated 10.5 FGFR2 FGFR3
4 trigonocephaly 1 10.5 FGFR2 FGFR3
5 ocular hypotension 10.5 FGFR2 FGFR3
6 villonodular synovitis 10.5 CHN1 KANTR
7 apert syndrome 10.5 FGFR2 FGFR3
8 monofixation syndrome 10.5 CHN1 TUBB3
9 hypogonadotropic hypogonadism 2 with or without anosmia 10.5 FGFR2 FGFR3
10 fuchs' endothelial dystrophy 10.4 CHN1 KANTR
11 adenosquamous bile duct carcinoma 10.4 CHN1 KANTR
12 peters-plus syndrome 10.4 FOXL2 TUBB3
13 endometriosis of ovary 10.4 CHN1 KIF21A TUBB3
14 mental retardation, autosomal recessive 59 10.4 CHN1 KIF21A TUBB3
15 microcephaly-micromelia syndrome 10.4 CHN1 KIF21A TUBB3
16 enterocele 10.4 CHN1 KIF21A TUBB3
17 ulceration of vulva 10.4 CHN1 KIF21A TUBB3
18 crouzon syndrome with acanthosis nigricans 10.4 FGFR2 FGFR3
19 anal colloid adenocarcinoma 10.3 FOXL2 KANTR
20 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 KANTR SAMHD1
21 porencephaly 10.3 FOXL2 KIF21A TUBB3
22 bacterial meningitis 10.3 KANTR TUBB3
23 thanatophoric dysplasia, type i 10.3 FGFR2 FGFR3
24 benign paroxysmal positional nystagmus 10.2 KANTR TUBB3
25 cardiovascular cancer 10.2 KANTR TUBB3
26 uterine corpus epithelioid leiomyoma 10.2 SAMHD1 TTR
27 right bundle branch block 10.1 KANTR TG
28 disuse amblyopia 10.1 CHN1 TUBB3
29 guillain-barre syndrome 10.1 KANTR TG
30 exotropia 10.1
31 total circumpapillary dystrophy of choroid 10.1 CHN1 KANTR SAMHD1
32 macrocystic neurilemmoma 10.1 KANTR SAMHD1
33 paraplegia 10.1 KANTR TTR
34 diphtheria 10.0 SAMHD1 TG
35 rheumatic disease 9.9 KANTR LAX1
36 ichthyosis lamellar 1 9.9 FGFR2 FGFR3 TTR
37 ancylostomiasis 9.9 KANTR LAX1
38 hallucinogen abuse 9.9 KANTR LAX1
39 polydactyly, postaxial, with progressive myopia 9.9 CHN1 TUBB3
40 c5 deficiency 9.9 FGFR2 TG
41 iridocyclitis 9.9 FGFR2 TG
42 tinea profunda 9.9 KANTR LAX1
43 pleomorphic carcinoma 9.9 CHN1 KANTR KIF21A TUBB3
44 necrobiosis lipoidica 9.9 LAX1 TTR
45 cervical clear cell adenocarcinoma 9.9 FOXL2 LAX1
46 strabismus 9.9
47 epidural abscess 9.8 SAMHD1 TG
48 prostate carcinoma in situ 9.8 KANTR TTR TUBB3
49 lung lymphoma 9.7 TG TTR TUBB3
50 cataract 9.7

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2 abobotulinumtoxinA
3 Botulinum Toxins
4 Botulinum Toxins, Type A
5 Cholinergic Agents
6 Neurotransmitter Agents
7 onabotulinumtoxinA

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Prospective Observational Study of Adult Strabismus Recruiting NCT02510040
2 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

39
Eye

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 59)
id Title Authors Year
1
Resolution of hypertropia with correction of consecutive horizontal deviation. ( 28499831 )
2017
2
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. ( 27787462 )
2016
3
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. ( 26928363 )
2016
4
Hypertropia in unilateral isolated abducens palsy. ( 24924275 )
2014
5
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? ( 25477320 )
2014
6
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. ( 24767828 )
2014
7
Accuracy of double maddox rod with induced hypertropia in normal subjects. ( 25313115 )
2014
8
Isolated inferior oblique myectomy for hypertropia. ( 25603661 )
2014
9
Resolution of hypertropia with correction of intermittent exotropia. ( 23934140 )
2013
10
Relationship of hypertropia and excyclotorsion in superior oblique palsy. ( 23372378 )
2013
11
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. ( 23993717 )
2013
12
Inferior oblique transposition for large hypertropia after vertical rectus transposition. ( 23618631 )
2013
13
Hypertropia following Spontaneous Resolution of Brown's Syndrome. ( 22855678 )
2012
14
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. ( 21057518 )
2011
15
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. ( 21282574 )
2011
16
Surgical management of clinically significant hypertropia associated with exotropia. ( 20603056 )
2010
17
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. ( 20337346 )
2010
18
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. ( 19065984 )
2008
19
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? ( 19132949 )
2008
20
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. ( 18670464 )
2008
21
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. ( 17572341 )
2007
22
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. ( 17016462 )
2007
23
A case of intramuscular hemangioma presenting with large-angle hypertropia. ( 17004637 )
2006
24
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. ( 16908815 )
2006
25
Incidence and types of childhood hypertropia: a population-based study. ( 16647125 )
2006
26
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. ( 15977869 )
2005
27
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. ( 15314594 )
2004
28
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. ( 15747755 )
2004
29
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. ( 12917609 )
2003
30
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. ( 12067267 )
2002
31
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. ( 11874381 )
2002
32
Two entities in which a dissociative hypertropia may present after surgery. ( 11874375 )
2002
33
Monofixation with eso-, exo-, or hypertropia: is there a difference? ( 21149032 )
2001
34
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. ( 10845415 )
2000
35
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. ( 9852443 )
1998
36
Hypertropia and the posterior blowout fracture. ( 8684811 )
1996
37
Hypertropia and the posterior blowout fracture: Mechanism and management. ( 8628546 )
1996
38
Ipsilateral hypertropia after cataract surgery. ( 8637680 )
1996
39
Unilateral congenital fibrosis syndrome presenting with hypertropia. ( 8154269 )
1993
40
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. ( 1286718 )
1992
41
Hypertropia after implantation of a Molteno drainage device. ( 1728155 )
1992
42
Hypertropia following trochlear trauma. ( 1432500 )
1992
43
Alternating skew on lateral gaze (bilateral abducting hypertropia). ( 3377440 )
1988
44
Dissociated hypertropia: surgical treatment. ( 542245 )
1979
45
Superior oblique strengthening procedures in hypertropia I and II. ( 438930 )
1979
46
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. ( 749595 )
1978
47
Treatment of hypertropia by vertical displacement of horizontal recti. ( 900607 )
1977
48
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. ( 5089863 )
1971
49
Prismatic correction of a large progressive hypertropia. ( 5246998 )
1968
50
Alternating hyperphoria and hypertropia. ( 13991876 )
1963

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 bone mineralization GO:0030282 9.26 FGFR2 FGFR3
2 bone morphogenesis GO:0060349 9.16 FGFR2 FGFR3
3 positive regulation of phospholipase activity GO:0010518 8.96 FGFR2 FGFR3
4 endochondral bone growth GO:0003416 8.62 FGFR2 FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....