MCID: HYP047
MIFTS: 28

Hypertropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypertropia

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Aliases & Descriptions for Hypertropia:

Name: Hypertropia 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:9837
ICD1028 H50.2
ICD9CM30 378.31
SNOMED-CT60 194109005, 40608009
MeSH37 D013285
NCIt43 C34716

Summaries for Hypertropia

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Wikipedia:69 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypertropia is related to hypotropia and endometriosis of rectovaginal septum and vagina. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways are Alzheimers Disease Pathway and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include eye.

Related Diseases for Hypertropia

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Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1hypotropia30.1CHN1, KANTR, SAMHD1
2endometriosis of rectovaginal septum and vagina10.6CHN1, KIF21A
3chandler syndrome10.4CHN1, KANTR
4adenosquamous breast carcinoma10.4CHN1, KANTR
5mucopolysaccharidosis10.4CHN1, KIF21A
6flnb-related disorders10.4FGFR2, FGFR3
7plasmalogens synthesis deficiency isolated10.4FGFR2, FGFR3
8trigonocephaly 110.4FGFR2, FGFR3
9mite infestation10.4FGFR2, FGFR3
10b-cell childhood acute lymphoblastic leukemia10.4CHN1, KIF21A
11bladder cancer, somatic10.4FGFR2, FGFR3
12apert syndrome10.3FGFR2, FGFR3
13meckel syndrome 310.3CHN1, FOXL2, KIF21A
14hypogonadotropic hypogonadism 2 with or without anosmia10.3FGFR2, FGFR3
15vaginal adenoma10.3CHN1, FGFR2, KIF21A
16idiopathic juvenile osteoporosis10.3CHN1, KIF21A
17brachial plexus neuropathy10.3FOXL2, KANTR
18central nervous system leukemia10.3FGFR2, FGFR3
19crouzon syndrome with acanthosis nigricans10.3FGFR2, FGFR3
20thanatophoric dysplasia, type i10.2FGFR2, FGFR3
21melanocytic psammomatous mpnst10.2KANTR, SAMHD1
22exotropia10.2
23glaucomatocyclitic crisis10.2FGFR2, FGFR3
24antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
25monofixation syndrome10.2CHN1, KIF21A, SAMHD1
26lymphoepithelioma-like carcinoma10.2CHN1, KANTR, KIF21A
27scleredema adultorum10.2FGFR2, FGFR3
28neurilemmoma of the fifth cranial nerve10.1KANTR, SAMHD1
29abnormal threshold of rods10.1KANTR, TTR
30lesion of sciatic nerve10.1KANTR, TTR
31schistosomiasis10.0SAMHD1, TTR
32ovarian mucinous neoplasm10.0KANTR, TTR
33ischemic bone disease10.0FGFR2, FGFR3
34apraxia10.0KANTR, SAMHD1
35strabismus10.0
36uterine ligament clear cell adenocarcinoma10.0FOXL2, LAX1
37tinea cruris10.0KANTR, SAMHD1
38communicating hydrocephalus9.9KANTR, LAX1
39prolapse of female genital organ9.9KANTR, LAX1
40ocular motility disease9.9KANTR, LAX1
41beare-stevenson cutis gyrata syndrome9.9FGFR2, FGFR3
42reading disorder9.9KANTR, LAX1
43cataract9.8
44hemangioma9.8
45amblyopia9.8
46synostosis9.8
47retinitis9.8
48intramuscular hemangioma9.8
49retinal detachment9.8
50abducens palsy9.8

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to hypertropia

Symptoms for Hypertropia

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Drugs & Therapeutics for Hypertropia

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Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Acetylcholine75251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Prospective Observational Study of Adult StrabismusRecruitingNCT02510040
2Routine Care Study Evaluating Ocular TorsionNot yet recruitingNCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

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Anatomical Context for Hypertropia

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MalaCards organs/tissues related to Hypertropia:

34
Eye

Animal Models for Hypertropia or affiliated genes

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Publications for Hypertropia

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Articles related to Hypertropia:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Hypertropia in unilateral isolated abducens palsy. (24924275)
2014
2
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? (25477320)
2014
3
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. (24767828)
2014
4
Isolated inferior oblique myectomy for hypertropia. (25603661)
2014
5
Resolution of hypertropia with correction of intermittent exotropia. (23934140)
2013
6
Inferior oblique transposition for large hypertropia after vertical rectus transposition. (23618631)
2013
7
Relationship of hypertropia and excyclotorsion in superior oblique palsy. (23372378)
2013
8
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. (23993717)
2013
9
Hypertropia following Spontaneous Resolution of Brown's Syndrome. (22855678)
2012
10
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. (21282574)
2011
11
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. (21057518)
2011
12
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. (20337346)
2010
13
Surgical management of clinically significant hypertropia associated with exotropia. (20603056)
2010
14
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? (19132949)
2008
15
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. (18670464)
2008
16
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. (19065984)
2008
17
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. (17572341)
2007
18
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. (17016462)
2007
19
Incidence and types of childhood hypertropia: a population-based study. (16647125)
2006
20
A case of intramuscular hemangioma presenting with large-angle hypertropia. (17004637)
2006
21
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. (15977869)
2005
22
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. (15314594)
2004
23
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. (15747755)
2004
24
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. (12067267)
2002
25
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. (11874381)
2002
26
Two entities in which a dissociative hypertropia may present after surgery. (11874375)
2002
27
Monofixation with eso-, exo-, or hypertropia: is there a difference? (21149032)
2001
28
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. (10845415)
2000
29
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. (9852443)
1998
30
Hypertropia and the posterior blowout fracture. (8684811)
1996
31
Ipsilateral hypertropia after cataract surgery. (8637680)
1996
32
Hypertropia and the posterior blowout fracture: Mechanism and management. (8628546)
1996
33
Unilateral congenital fibrosis syndrome presenting with hypertropia. (8154269)
1993
34
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. (1286718)
1992
35
Hypertropia following trochlear trauma. (1432500)
1992
36
Hypertropia after implantation of a Molteno drainage device. (1728155)
1992
37
Alternating skew on lateral gaze (bilateral abducting hypertropia). (3377440)
1988
38
Superior oblique strengthening procedures in hypertropia I and II. (438930)
1979
39
Dissociated hypertropia: surgical treatment. (542245)
1979
40
Surgical management of small-angle hypertropia by vertical displacement of the horizontal rectus muscles. (749595)
1978
41
First Annual Richard G. Scobee Memorial Lecture. Diagnosis and surgical treatment of hypertropia. (5089863)
1971
42
Alternating hyperphoria and hypertropia. (13991876)
1963
43
Alternating hypertropia. (13744524)
1961
44
Post-inflammatory ectopia of the macula resulting in apparent hypertropia. (13364190)
1956
45
Hypertropia corrected by changes of the lateral rectus insertion. (13182170)
1954
46
The significance of alternating hypertropia in concomitant strabismus. (14923774)
1952
47
Postoperative hypertropia. (18894714)
1948
48
Tenotomy of the superior oblique muscle for hypertropia; preliminary report. (20273126)
1947
49
Tenotomy of the Superior Oblique for Hypertropia: Preliminary Report. (16693420)
1946
50
Orthoptic Training and Surgery in Hyperphoria and Hypertropia Combined with Lateral Deviations. (16693008)
1934

Variations for Hypertropia

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Expression for genes affiliated with Hypertropia

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Search GEO for disease gene expression data for Hypertropia.

Pathways for genes affiliated with Hypertropia

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Pathways related to Hypertropia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6FGFR2, FGFR3
29.6FGFR2, FGFR3
39.3CHN1, FGFR2, FGFR3

GO Terms for genes affiliated with Hypertropia

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Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:00105189.7FGFR2, FGFR3
2bone morphogenesisGO:00603499.6FGFR2, FGFR3
3bone mineralizationGO:00302829.3FGFR2, FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.0FGFR2, FGFR3
2fibroblast growth factor bindingGO:00171349.6FGFR2, FGFR3
31-phosphatidylinositol-3-kinase activityGO:00163039.5FGFR2, FGFR3

Sources for Hypertropia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet