MCID: HYP014
MIFTS: 56

Hyperuricemia malady

Blood diseases, Rare diseases categories

Summaries for Hyperuricemia

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and lesch-nyhan syndrome. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Purine metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds benzbromarone and pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:66 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

hyperuricemia 9 11 46 63
blood urate raized 9
hyperuricaemia 9
uricacidaemia 9
uricacidemia 9


External Ids:

Disease Ontology9 DOID:1920
NCIt41 C3961
MeSH36 D033461
ICD1026 E79.0

Related Diseases for Hyperuricemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hyperuricemia family:

Hereditary Hyperuricemia

Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.5UMOD, HPRT1
2lesch-nyhan syndrome30.7HPRT1, XDH
3insulin resistance30.3FABP2, ADRB3, G6PC
4atherosclerosis30.2FABP2, ADRB3, XDH
5fatty liver disease30.2FABP2, ADRB3
6nephrolithiasis30.1SLC22A12, UMOD, HPRT1, XDH
7type 2 diabetes mellitus30.0G6PC, PFKM, ADRB3, FABP2
8diabetes mellitus30.0G6PC, PFKM, ADRB3, FABP2, UMOD
9familial juvenile hyperuricemic nephropathy29.9HPRT1, UMOD
10glycogen storage disease29.8G6PC, PFKM
11hypertriglyceridemia29.8G6PC, ADRB3, FABP2
12coronary artery disease29.8XDH, ADRB3, FABP2
13hypertension10.7
14kidney disease10.5
15obesity10.5
16endotheliitis10.4
17hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
18cystinuria10.2
19arthritis10.2
20blindness10.2
21nephronophthisis10.2
22essential hypertension10.2
23deafness hyperuricemia neurologic ataxia10.2
24hereditary hyperuricemia10.2
25psoriatic arthritis10.1
26acute myocardial infarction10.1
27hodgkin's lymphoma10.1
28leukemia10.1
29liver disease10.1
30myocardial infarction10.1
31athetosis10.1
32glycogen storage disease type 1a10.1
33nephropathy familial with hyperuricemia10.1
34renal hypouricemia10.1HPRT1, SLC22A12
35acute urate nephropathy10.0XDH, HPRT1
36developmental disabilities10.0HPRT1, G6PC
37hepatitis c10.0
38hemolytic-uremic syndrome10.0
39hepatitis10.0
40polycythemia10.0
41proteinuria10.0
42medullary cystic kidney disease type 110.0
43phosphoribosylpyrophosphate synthetase superactivity10.0
44umod-associated kidney disease10.0
45cardiovascular disease risk factor10.0
46erythrocytosis10.0
47glomerulocystic kidney disease with hyperuricemia and isosthenuria10.0
48hprt-related gout10.0
49autosomal dominant medullary cystic kidney disease with hyperuricemia10.0
50morbid obesity10.0FABP2, ADRB3

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Symptoms for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hyperuricemia

Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Search CenterWatch for Hyperuricemia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Hyperuricemia:

34
Kidney, Heart, Endothelial, Liver, Bone marrow, Testes, Thyroid, Breast, Myeloid, Bone, Cortex

Animal Models for Hyperuricemia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hyperuricemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2XDH, ADRB3, FABP2, UMOD
2MP:00053678.0XDH, G6PC, FABP2, HPRT1, UMOD, SLC22A12
3MP:00053867.8SLC22A12, HPRT1, ADRB3, PFKM, G6PC
4MP:00053797.7XDH, PFKM, ADRB3, HPRT1, SLC22A12
5MP:00053787.3XDH, G6PC, ADRB3, FABP2, HPRT1, UMOD
6MP:00053766.6SLC22A12, XDH, G6PC, PFKM, ADRB3, FABP2

Publications for Hyperuricemia

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Sources:
53PubMed
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Articles related to Hyperuricemia:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
2
Definition of hyperuricemia and gouty conditions. (24419750)
2014
3
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
4
Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. (23942050)
2013
5
Hyperuricemia is associated with hypertension, obesity, and albuminuria in children with chronic kidney disease. (22809658)
2013
6
The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study. (24308550)
2013
7
Mediterranean diet and risk of hyperuricemia in elderly participants at high cardiovascular risk. (23599357)
2013
8
Variation of urate transport in the nephrons in subtypes of hyperuricemia. (24052801)
2013
9
Hyperuricemia and non-dipping blood pressure. (24348063)
2013
10
Splenectomy is a risk factor for developing hyperuricemia and nephrolithiasis in patients with thalassemia intermedia: a retrospective study. (22705193)
2012
11
Hyperuricemia and metabolic syndrome in children with overweight and obesity. (23089370)
2012
12
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
13
Rasburicase in cancer-related hyperuricemia. (21850282)
2011
14
The prevalence of hyperuricemia in China: a meta-analysis. (22032610)
2011
15
Japanese guideline for the management of hyperuricemia and gout: second edition. (22132951)
2011
16
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (21654265)
2011
17
Lack of association between dietary fructose and hyperuricemia risk in adults. (20193069)
2010
18
Gout and hyperuricemia. (21229813)
2010
19
Association of urinary albumin excretion rate and hyperuricemia with macrovascular atherosclerosis in type 2 diabetic patients]. (20118005)
2010
20
A study of rasburicase for the management of hyperuricemia in pediatric patients with newly diagnosed hematologic malignancies at high risk for tumor lysis syndrome. (19701676)
2009
21
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
22
Efficacy and safety of losartan in treatment of hyperuricemia and posttransplantation erythrocytosis: results of a prospective, open, randomized, case-control study. (19917377)
2009
23
Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome. (18992978)
2009
24
Outcome of directly observed treatment short course (DOTS) in a case of pulmonary tuberculosis with hyperuricemia. (19810595)
2009
25
Hyperuricemia is associated with the development of the composite outcomes of new cardiovascular events and chronic allograft nephropathy. (18791445)
2008
26
The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. (17225053)
2007
27
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. (17190912)
2007
28
Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. (17396159)
2007
29
Prevalence of the metabolic syndrome in individuals with hyperuricemia. (17466656)
2007
30
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (16385546)
2006
31
Is hyperuricemia a cardiovascular risk factor?]. (17017483)
2006
32
Is hyperuricemia another facet of the metabolic syndrome? (16599014)
2006
33
Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. (16448895)
2006
34
Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children. (16911488)
2006
35
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. (16820043)
2006
36
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
37
Hyperuricemia and bone marrow transplantation. (15604610)
2005
38
The effect of alcoholic beverage type on hyperuricemia in Japanese male office workers. (15762093)
2005
39
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. (15824465)
2004
40
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
41
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. (15170929)
2004
42
Diuretic-induced hyperuricemia does not decrease cardiovascular risk. (15201561)
2004
43
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
44
Pathogenesis of hyperuricemia: recent advances. (12010614)
2002
45
Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. (11398134)
2001
46
Latent overproductive hyperuricemia increases in patients during the intermittent phase of gouty arthritis under long-term antihyperuricemic treatment. (24383630)
2000
47
Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. (10413068)
1999
48
Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. (10571797)
1999
49
Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant recipients. (10515217)
1999
50
Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report. (5495289)
1970

Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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Sources:
51PathCards, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Hyperuricemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC22A12, XDH
2
Show member pathways
purine deoxyribonucleosides degradation39
purine nucleotides degradation39
adenine and adenosine salvage II39
adenine and adenosine salvage III39
oxidized GTP and dGTP detoxification39
urate biosynthesis/inosine 5-phosphate degradation39
adenine and adenosine salvage I39
purine ribonucleosides degradation to ribose-1-phosphate39
inosine-5-phosphate biosynthesis39
guanosine nucleotides degradation39
guanine and guanosine salvage39
adenosine nucleotides degradation39
5-aminoimidazole ribonucleotide biosynthesis39
9.5HPRT1, XDH
3
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.2PFKM, G6PC
4
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I39
galactose degradation I (Leloir pathway)39
Cori Cycle39
9.2G6PC, PFKM
5
Show member pathways
9.1HPRT1, G6PC, XDH

Compounds for genes affiliated with Hyperuricemia

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1benzbromarone4610.0SLC22A12, XDH
2pyrazinamide46 52 1212.0XDH, SLC22A12
36-thiouric acid4610.0HPRT1, XDH
42,8-dihydroxyadenine4610.0HPRT1, XDH
5tiazofurin469.9XDH, HPRT1
6mercaptopurine52 1210.9HPRT1, XDH
7didanosine46 52 1211.9HPRT1, XDH
8thiopurine469.9HPRT1, XDH
96 mercaptopurine469.9HPRT1, XDH
10probenecid30 46 62 52 1213.9XDH, SLC22A12
11purine nucleoside469.9XDH, HPRT1
12inosine46 2510.8XDH, HPRT1
13hypoxanthine46 25 1211.8HPRT1, XDH
14acetaldehyde30 46 2511.8HPRT1, XDH
15xanthine46 2510.7HPRT1, XDH
16succinate469.7HPRT1, G6PC
17peroxynitrite469.7UMOD, XDH
18galactose469.7UMOD, G6PC
19malondialdehyde469.6XDH, G6PC
20carvedilol46 52 30 1212.6ADRB3, XDH
21allopurinol46 52 1211.6XDH, HPRT1, UMOD
22losartan46 52 30 1212.6SLC22A12, XDH
23pyrophosphate46 2510.5HPRT1, SARS2, G6PC
24dmso469.5HPRT1, G6PC, XDH
25nadph46 2510.2XDH, G6PC, FABP2
26pyruvate469.0G6PC, PFKM, FABP2
27carnitine469.0SLC22A12, PFKM
28cysteine469.0UMOD, HPRT1, FABP2, XDH
29urea46 25 1211.0G6PC, ADRB3, FABP2, UMOD
30adenylate468.9G6PC, ADRB3, HPRT1
31lactate468.9PFKM, G6PC, XDH
32magnesium46 25 1210.8G6PC, PFKM, HPRT1, UMOD
33arginine468.8XDH, G6PC, ADRB3, HPRT1
34creatinine468.5SLC22A12, UMOD, HPRT1, FABP2, PFKM
35glycogen46 259.5G6PC, PFKM, ADRB3, FABP2
36fatty acid468.4FABP2, ADRB3, PFKM, G6PC
37alanine468.4FABP2, ADRB3, PFKM, G6PC
38uric acid46 259.2SLC22A12, UMOD, HPRT1, ADRB3, G6PC, XDH
39glucose468.1G6PC, PFKM, ADRB3, FABP2, UMOD
40lipid467.9XDH, G6PC, PFKM, ADRB3, FABP2

GO Terms for genes affiliated with Hyperuricemia

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17Gene Ontology
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Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.0SLC22A12, UMOD, PFKM

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1urate metabolic processGO:0464159.8SLC22A12, G6PC
2purine nucleobase metabolic processGO:0061449.6HPRT1, XDH
3nucleobase-containing small molecule metabolic processGO:0550869.4XDH, HPRT1
4glucose homeostasisGO:0425939.2PFKM, G6PC
5carbohydrate metabolic processGO:0059758.6ADRB3, PFKM, G6PC
6small molecule metabolic processGO:0442818.0HPRT1, PFKM, G6PC, XDH

Products for genes affiliated with Hyperuricemia

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  • Antibodies
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Sources for Hyperuricemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet