MCID: HYP014
MIFTS: 55

Hyperuricemia malady

Metabolic diseases, Blood diseases, Rare diseases categories

Summaries for Hyperuricemia

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Disease Ontology:9 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards based summary: Hyperuricemia, also known as blood urate raized, is related to gout and lesch-nyhan syndrome. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Purine metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds benzbromarone and pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:64 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Hyperuricemia, Aliases & Descriptions:

Name: Hyperuricemia 9 11 44 61
Blood Urate Raized 9
 
Uricacidemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:1920
NCIt39 C3961
MeSH34 D033461

Related Diseases for Hyperuricemia

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Diseases in the Hyperuricemia family:

Hereditary Hyperuricemia

Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.8UMOD, HPRT1
2lesch-nyhan syndrome31.1HPRT1, XDH
3nephrolithiasis30.5UMOD, XDH
4familial juvenile hyperuricemic nephropathy30.5HPRT1, UMOD
5fatty liver disease30.2FABP2, ADRB3
6insulin resistance30.2FABP2, ADRB3, G6PC
7glycogen storage disease29.8G6PC, PFKM
8atherosclerosis29.8FABP2, ADRB3, XDH
9hypertriglyceridemia29.7G6PC, ADRB3, FABP2
10type 2 diabetes mellitus29.5G6PC, PFKM, ADRB3, FABP2
11diabetes mellitus29.3G6PC, PFKM, ADRB3, FABP2, UMOD
12hypertension10.7
13kidney disease10.6
14obesity10.5
15endotheliitis10.4
16renal hypouricemia10.3HPRT1, SLC22A12
17hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
18arthritis10.2
19cystinuria10.2
20hereditary hyperuricemia10.2
21blindness10.2
22acute urate nephropathy10.2XDH, HPRT1
23liver disease10.2
24nephronophthisis10.2
25essential hypertension10.2
26deafness hyperuricemia neurologic ataxia10.2
27developmental disabilities10.2HPRT1, G6PC
28acute myocardial infarction10.1
29hepatitis10.1
30hodgkin's lymphoma10.1
31leukemia10.1
32myocardial infarction10.1
33psoriatic arthritis10.1
34athetosis10.1
35glycogen storage disease type 1a10.1
36nephropathy familial with hyperuricemia10.1
37morbid obesity10.1FABP2, ADRB3
38familial combined hyperlipidemia10.1ADRB3, FABP2
39ischemic heart disease10.0
40pulmonary hypertension10.0
41hepatitis c10.0
42hemolytic-uremic syndrome10.0
43polycythemia10.0
44proteinuria10.0
45psoriasis10.0
46medullary cystic kidney disease type 110.0
47phosphoribosylpyrophosphate synthetase superactivity10.0
48umod-associated kidney disease10.0
49cardiovascular disease risk factor10.0
50glomerulocystic kidney disease with hyperuricemia and isosthenuria10.0

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Symptoms for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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MalaCards organs/tissues related to Hyperuricemia:

32
Kidney, Heart, Endothelial, Liver, Bone marrow, Bone, Cortex, Thyroid, Breast, Testes, Myeloid, Neutrophil

Animal Models for Hyperuricemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperuricemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2XDH, ADRB3, FABP2, UMOD
2MP:00053678.0XDH, G6PC, FABP2, HPRT1, UMOD, SLC22A12
3MP:00053867.8SLC22A12, HPRT1, ADRB3, PFKM, G6PC
4MP:00053797.7XDH, PFKM, ADRB3, HPRT1, SLC22A12
5MP:00053787.3XDH, G6PC, ADRB3, FABP2, HPRT1, UMOD
6MP:00053766.6SLC22A12, XDH, G6PC, PFKM, ADRB3, FABP2

Publications for Hyperuricemia

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Articles related to Hyperuricemia:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
2
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
3
Definition of hyperuricemia and gouty conditions. (24419750)
2014
4
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
5
Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. (23942050)
2013
6
Hyperuricemia is associated with hypertension, obesity, and albuminuria in children with chronic kidney disease. (22809658)
2013
7
The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study. (24308550)
2013
8
Variation of urate transport in the nephrons in subtypes of hyperuricemia. (24052801)
2013
9
Hyperuricemia and non-dipping blood pressure. (24348063)
2013
10
Splenectomy is a risk factor for developing hyperuricemia and nephrolithiasis in patients with thalassemia intermedia: a retrospective study. (22705193)
2012
11
Hyperuricemia and metabolic syndrome in children with overweight and obesity. (23089370)
2012
12
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
13
Rasburicase in cancer-related hyperuricemia. (21850282)
2011
14
The prevalence of hyperuricemia in China: a meta-analysis. (22032610)
2011
15
Japanese guideline for the management of hyperuricemia and gout: second edition. (22132951)
2011
16
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (21654265)
2011
17
Lack of association between dietary fructose and hyperuricemia risk in adults. (20193069)
2010
18
Gout and hyperuricemia. (21229813)
2010
19
Association of urinary albumin excretion rate and hyperuricemia with macrovascular atherosclerosis in type 2 diabetic patients]. (20118005)
2010
20
A study of rasburicase for the management of hyperuricemia in pediatric patients with newly diagnosed hematologic malignancies at high risk for tumor lysis syndrome. (19701676)
2009
21
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
22
Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome. (18992978)
2009
23
Outcome of directly observed treatment short course (DOTS) in a case of pulmonary tuberculosis with hyperuricemia. (19810595)
2009
24
Hyperuricemia is associated with the development of the composite outcomes of new cardiovascular events and chronic allograft nephropathy. (18791445)
2008
25
The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. (17225053)
2007
26
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. (17190912)
2007
27
Drug discovery for hyperuricemia. (23496132)
2007
28
Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. (17396159)
2007
29
Prevalence of the metabolic syndrome in individuals with hyperuricemia. (17466656)
2007
30
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (16385546)
2006
31
Is hyperuricemia a cardiovascular risk factor?]. (17017483)
2006
32
Is hyperuricemia another facet of the metabolic syndrome? (16599014)
2006
33
Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. (16448895)
2006
34
Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children. (16911488)
2006
35
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. (16820043)
2006
36
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
37
Hyperuricemia and bone marrow transplantation. (15604610)
2005
38
The effect of alcoholic beverage type on hyperuricemia in Japanese male office workers. (15762093)
2005
39
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. (15824465)
2004
40
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
41
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. (15170929)
2004
42
Diuretic-induced hyperuricemia does not decrease cardiovascular risk. (15201561)
2004
43
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
44
Pathogenesis of hyperuricemia: recent advances. (12010614)
2002
45
Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. (11398134)
2001
46
Latent overproductive hyperuricemia increases in patients during the intermittent phase of gouty arthritis under long-term antihyperuricemic treatment. (24383630)
2000
47
Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. (10413068)
1999
48
Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. (10571797)
1999
49
Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant recipients. (10515217)
1999
50
Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report. (5495289)
1970

Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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Pathways related to Hyperuricemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC22A12, XDH
2
Show member pathways
purine deoxyribonucleosides degradation37
purine nucleotides degradation37
adenine and adenosine salvage II37
adenine and adenosine salvage III37
oxidized GTP and dGTP detoxification37
urate biosynthesis/inosine 5-phosphate degradation37
adenine and adenosine salvage I37
purine ribonucleosides degradation to ribose-1-phosphate37
inosine-5-phosphate biosynthesis37
guanosine nucleotides degradation37
guanine and guanosine salvage37
adenosine nucleotides degradation37
5-aminoimidazole ribonucleotide biosynthesis37
9.5HPRT1, XDH
3
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.2PFKM, G6PC
4
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I37
galactose degradation I (Leloir pathway)37
Cori Cycle37
9.2G6PC, PFKM
5
Show member pathways
9.1HPRT1, G6PC, XDH

Compounds for genes affiliated with Hyperuricemia

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Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1benzbromarone4410.0SLC22A12, XDH
2pyrazinamide44 50 1212.0XDH, SLC22A12
36-thiouric acid4410.0HPRT1, XDH
42,8-dihydroxyadenine4410.0HPRT1, XDH
5tiazofurin449.9XDH, HPRT1
6mercaptopurine50 1210.9HPRT1, XDH
7didanosine44 50 1211.9HPRT1, XDH
8thiopurine449.9HPRT1, XDH
96 mercaptopurine449.9HPRT1, XDH
10probenecid29 44 60 50 1213.9XDH, SLC22A12
11purine nucleoside449.9XDH, HPRT1
12inosine44 2510.8XDH, HPRT1
13hypoxanthine44 25 1211.8HPRT1, XDH
14acetaldehyde29 44 2511.8HPRT1, XDH
15xanthine44 2510.7HPRT1, XDH
16succinate449.7HPRT1, G6PC
17peroxynitrite449.7UMOD, XDH
18galactose449.7UMOD, G6PC
19malondialdehyde449.6XDH, G6PC
20carvedilol44 50 29 1212.6ADRB3, XDH
21allopurinol44 50 1211.6XDH, HPRT1, UMOD
22losartan44 50 29 1212.6SLC22A12, XDH
23pyrophosphate44 2510.5HPRT1, SARS2, G6PC
24dmso449.5HPRT1, G6PC, XDH
25nadph44 2510.2XDH, G6PC, FABP2
26pyruvate449.0G6PC, PFKM, FABP2
27carnitine449.0SLC22A12, PFKM
28cysteine449.0UMOD, HPRT1, FABP2, XDH
29urea44 25 1211.0G6PC, ADRB3, FABP2, UMOD
30adenylate448.9G6PC, ADRB3, HPRT1
31lactate448.9PFKM, G6PC, XDH
32magnesium44 25 1210.8G6PC, PFKM, HPRT1, UMOD
33arginine448.8XDH, G6PC, ADRB3, HPRT1
34creatinine448.5SLC22A12, UMOD, HPRT1, FABP2, PFKM
35glycogen44 259.5G6PC, PFKM, ADRB3, FABP2
36fatty acid448.4FABP2, ADRB3, PFKM, G6PC
37alanine448.4FABP2, ADRB3, PFKM, G6PC
38uric acid44 259.2SLC22A12, UMOD, HPRT1, ADRB3, G6PC, XDH
39glucose448.1G6PC, PFKM, ADRB3, FABP2, UMOD
40lipid447.9XDH, G6PC, PFKM, ADRB3, FABP2

GO Terms for genes affiliated with Hyperuricemia

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Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.0SLC22A12, UMOD, PFKM

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1urate metabolic processGO:0464159.8SLC22A12, G6PC
2purine nucleobase metabolic processGO:0061449.6HPRT1, XDH
3nucleobase-containing small molecule metabolic processGO:0550869.4XDH, HPRT1
4glucose homeostasisGO:0425939.2PFKM, G6PC
5carbohydrate metabolic processGO:0059758.6ADRB3, PFKM, G6PC
6small molecule metabolic processGO:0442818.0HPRT1, PFKM, G6PC, XDH

Products for genes affiliated with Hyperuricemia

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Sources for Hyperuricemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet