Hyperuricemia malady

Disease Ontology: An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.⁶

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and glomerulocystic kidney disease with hyperuricemia and isosthenuria. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Graft-versus-host disease and NFAT Signaling and Lymphocyte Interactions. The drugs mannitol hexanitrate and rasburicase and the compounds n acetylcysteine and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and kidney, and related mouse phenotypes are integument and endocrine/exocrine gland.

Wikipedia: Hyperuricemia (British English: hyperuricaemia) is a level of uric acid in the blood that is abnormally...⁴⁴ more...

Aliases & Descriptions:

hyperuricemia 6 8 32 43 blood urate raized 6 hyperuricaemia 6

uricacidaemia 6 uricacidemia 6

Diseases related to hyperuricemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 773)

id	Related Disease	Score	Top Affiliating Genes
1	gout	33.5	UMOD, HPRT1, SLC2A9
2	glomerulocystic kidney disease with hyperuricemia and isosthenuria	29.8	UMOD, MCKD2
3	familial juvenile hyperuricaemic nephropathy	28.4	UMOD, MCKD2
4	familial juvenile hyperuricemic nephropathy	28.1	UMOD, HPRT1
5	alcoholism	27.7	GSR, GPT, HTR2A, G6PD, GGT1
6	hypouricemia	27.5	XDH, INS, ALB, HPRT1, SLC2A9, SLC22A12
7	chronic kidney failure	26.0	REN, LPL, LEP, INS, ALB, TTR
8	ischemic heart disease	25.7	SELP, SERPINE1, LPL, LIPC, AMPD3, CRP
9	hypoglycemia	23.4	LPL, LEP, INS, IL1B, IL6, HTR2A
10	uremia	21.8	REN, SERPINE1, LPL, LIPC, LEP, INS
11	myopathy	21.3	LEP, SARS2, CD40LG, INS, IL1A, IL1B
12	insulin resistance	20.8	REN, SELP, SERPINE1, LPL, LIPC, LEP
13	essential hypertension	20.5	REN, SELP, SERPINE1, LPL, LIPC, LEP
14	pulmonary hypertension	19.8	REN, SELP, SERPINE1, SARS, SARS2, XDH
15	hypertension	19.3	REN, SELP, SERPINE1, LPL, LIPC, UMOD
16	obesity	18.6	REN, SELP, SERPINE1, LPL, LIPC, LEP
17	nephropathy	18.2	REN, SELP, SERPINE1, LPL, LIPC, UMOD
18	anemia	17.7	REN, SELP, LPL, LEP, MTHFR, XDH
19	atherosclerosis	17.1	REN, SELP, SERPINE1, LPL, LIPC, LEP
20	cholesterol	16.8	REN, SELP, SERPINE1, LPL, LIPC, LEP
21	umod-associated kidney disease	13.8	UMOD, MCKD2
22	acute urate nephropathy	13.8	XDH, HPRT1
23	renal hypouricemia	13.7	SLC2A9, SLC22A12
24	purine-pyrimidine metabolic disorder	13.7	AMPD3, HPRT1, ADA
25	glycogen storage disease i	13.6	LPL, G6PC, SLC37A4
26	adenine phosphoribosyltransferase deficiency	13.6	XDH, HPRT1
27	obstructive jaundice	13.6	GPT, TTR, GGT1
28	ariboflavinosis	13.5	MTHFR, GSR
29	combined hyperlipemia	13.5	LPL, LIPC, INS
30	favism	13.5	CAT, G6PC, G6PD
31	congenital generalized lipodystrophy	13.4	LEP, INS, LSL
32	hyporeninemic hypoaldosteronism	13.4	REN, INS
33	hypoalphalipoproteinemia	13.4	LPL, LIPC, GGT1
34	cholelithiasis	13.4	CD40LG, INS, GPT, G6PD, GGT1
35	choledocholithiasis	13.4	GPT, ALB, GGT1
36	creatine phosphokinase	13.4	GPT, SOD1, GGT1
37	skin tag	13.4	LEP, INS, LSL
38	gestational diabetes	13.4	LEP, INS, LSL, ADRB3
39	lipase deficiency combined	13.3	LPL, LIPC
40	calciphylaxis	13.3	CD40LG, INS, ALB
41	adult acute lymphocytic leukemia	13.3	MTHFR, ABCG2, TYMS
42	cryptosporidiosis	13.3	CD40LG, IL1A, CAT
43	bilirubin metabolic disorder	13.3	GPT, ALB, G6PD, GGT1
44	familial combined hyperlipidemia	13.3	LPL, LIPC, INS, LSL, ADRB3
45	gilbert syndrome	13.3	SELP, CD40LG, ABCG2, G6PD
46	intrahepatic cholestasis	13.3	LPL, LIPC, GPT, GGT1
47	parotitis	13.3	CRP, G6PD, GGT1
48	acanthosis nigricans	13.3	LEP, INS, ADRB3
49	catastrophic antiphospholipid syndrome	13.3	SERPINE1, MTHFR, CD40LG
50	hemoglobinuria	13.3	SELP, MTHFR, HPRT1, G6PD

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mannitol hexanitrate, rasburicase

MalaCards organs/tissues related to hyperuricemia:

²²

MGI Mouse Phenotypes related to hyperuricemia:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	9.9	CACNA1S, ABCG2, HPRT1, XDH, SELP
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	GGT1, ADRB3, ZPBP2, SLC22A12, PFKM, HPRT1
3	liver/biliary system phenotype	MP:0005370	9.2	ADA, SOD1, HPRT1, IL6, INS, LPL
4	reproductive system phenotype	MP:0005389	8.5	ZPBP2, TNF, HPRT1, IL6, LEP, LIPC
5	adipose tissue phenotype	MP:0005375	8.1	CACNA1S, ADRB3, TNF, IL6, INS, XDH
6	vision/eye phenotype	MP:0005391	7.4	TNF, TTR, SOD1, GGT1, HPRT1, IL6
7	muscle phenotype	MP:0005369	7.3	TNF, PFKM, SOD1, CACNA1S, HPRT1, HTR2A
8	cardiovascular system phenotype	MP:0005385	6.1	HPRT1, TNF, CRP, PFKM, G6PD, SOD1
9	mortality/aging	MP:0010768	INF	PFKM, G6PC, G6PD, SLC2A9, SLC22A12,
10	immune system phenotype	MP:0005387	INF	GGT1, , SLC2A9, PFKM, TNF, HPRT1
11	nervous system phenotype	MP:0003631	INF	CACNA1S, , SLC22A12, G6PD, G6PC, ABCG2
12	growth/size phenotype	MP:0005378	INF	G6PC, SLC2A9, SLC22A12, , ADA, ADRB3
13	homeostasis/metabolism phenotype	MP:0005376	INF	CACNA1S, TNF, CRP, PFKM, ABCG2, G6PC
14	renal/urinary system phenotype	MP:0005367	INF	, SLC22A12, SLC2A9, G6PC, HPRT1, INS
15	skeleton phenotype	MP:0005390	INF	CACNA1S, ADA, , IL6, INS, MTHFR
16	hematopoietic system phenotype	MP:0005397	INF	ADA, , SLC22A12, HPRT1
17	behavior/neurological phenotype	MP:0005386	INF	G6PC, SOD1, SLC2A9, SLC22A12, , ADRB3

Articles related to hyperuricemia:

(show top 50)    (show all 69)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkal osis, HUPRA syndrome. (21255763)	Belostotsky R.... Frishberg Y.	2011	SARS, SARS2
2	Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8. (21594610)	Kaneko H.... Ohno K.	2011	GPATCH8, ZPBP2
3	The association between single-nucleotide polymorphi sms of hURAT1 and hyperuricemia in Han Chinese]. (21211204)	Han L.... Li C.G.	2010	SLC22A12
4	Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients. (18853099)	Fu C.C.... Tseng C.H.	2009	CRP
5	Relationship between hyperuricemia (HUC) and metaboli c syndrome (MS) in institutionalized elderly men. (20005427)	Chang C.H.... Chen D.Y.	2009	SELP, TTR
6	Abdominal fat accumulation with hyperuricemia and hyp ercholesterolemia quail model induced by high fat diet. (19848323)	Lin Z.J.... Yang H.L.	2009	ADA, LPL, LIPC
7	Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricemia in Han Chi nese. (19833602)	Li C.... Mi Q.S.	2009	SLC2A9, SLC22A12
8	Hyperuricemia is a mediator of endothelial dysfunctio n and inflammation in renal allograft recipients. (19857674)	Karbowska A.... Klinger M.	2009	MCAM
9	Significant association between methylenetetrahydrofo late reductase 677T allele and hyperuricemia among adult Japanese subjects. (19917450)	Itou S.... Hamajima N.	2009	TYMS, MTHFR
10	Dominant renin gene mutations associated with early-o nset hyperuricemia, anemia, and chronic kidney failure. (19664745)	ZivnA! M.... Kmoch S.	2009	REN
11	Relationship between hyperuricemia and metabolic syndrome (18409529)	Yamasaki T.... Tomita K.	2008	INS
12	Historical review of gout and hyperuricemia investigations (18409506)	Nakamura T.	2008	UMOD
13	Definition and classification of hyperuricemia (18409507)	Yamamoto T.	2008	HPRT1, G6PC
14	Uromodulin mutation and hyperuricemia (18409531)	Kudo E.... Itakura M.	2008	UMOD
15	In addition to insulin resistance and obesity, hyperuricemia is strongly associated with metabolic syndrome using different definitions in Chinese populations: a population-based study (Taichung Community Health Study). (18292110)	Lin W.Y.... Lin C.C.	2008	INS
16	Primary hyperuricemia due to decreased renal uric acid excretion (18409514)	Yamauchi T.... Ueda T.	2008	UMOD
17	Prevalence of the metabolic syndrome in individuals with hyperuricemia. (17466656)	Choi H.K.... Ford E.S.	2007	INS
18	Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia. (17010581)	Golbahar J.... Rezaian G.R.	2007	MTHFR
19	Molecular basis of primary renal hyperuricemia : role of the human urate transporter hURAT1 (17891408)	Unger S.... Grassler J.	2007	SLC22A12
20	Febuxostat: a novel non-purine selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in gout. (19075968)	Yu K.H.	2007	XDH
21	Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (16385546)	Graessler J.... Schroeder H.-E.	2006	SLC22A12
22	An analysis of islet beta-cell function in hyperuricemia (16831320)	Jia S.D.... Li J.	2006	INS
23	Reduced-dose rasburicase (recombinant xanthine oxidase) in adult cancer patients with hyperuricemia. (16708061)	Trifilio S.... Mehta J.	2006	XDH
24	Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. (16356199)	Ganson N.J.... Hershfield M.S.	2006	CD40LG
25	Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout. (17132810)	Bruce S.P.	2006	XDH
26	Spotlight on rasburicase in anticancer therapy-induced hyperuricemia. (16724869)	Oldfield V.... Perry C.M.	2006	G6PD
27	The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over 5 years. (16328014)	Suwazono Y.... Nogawa K.	2006	GGT1, HTR2A
28	Febuxostat compared with allopurinol in patients with hyperuricemia and gout. (16339094)	Becker M.A.... Joseph-Ridge N.	2005	XDH
29	Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. (16932373)	Nakagawa T.... Johnson R.J.	2005	INS
30	Hyperuricemia and bone marrow transplantation. (15604610)	Deliliers G.L.... Annaloro C.	2005	TNF, IL6, XDH
31	The pathophysiology of hyperuricemia in essential hypertension: a pilot study. (15571230)	Puig J.G.... Bernardino J.I.	2004	INS
32	Pharmacokinetics and pharmacodynamics of febuxostat ( TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrog enase (NPSIXO) in patients with gout and/or hyperuricemia. (15571213)	Komoriya K.... Kamatani N.	2004	XDH
33	Clinical observation on treatment of nonalcoholic fa tty liver disease complicating hyperuricemia by Zhifang I Decoction (15339411)	Zhang X.Y.... Kuang C.B.	2004	GPT
34	Childhood hyperuricemia and acute renal failure resulting from a missense mutation in the HPRT gene. (11891689)	Srivastava T.... Simckes A.M.	2002	HPRT1
35	Gout and hyperuricemia. (11981327)	Wortmann R.L.	2002	INS
36	Rasburicase: an innovative new treatment for hyperuricemia associated with tumor lysis syndrome. (11842483)	Brant J.M.	2002	G6PD
37	Prevention and treatment of hyperuricemia in hematological malignancies. (12521386)	Cairo M.S.	2002	XDH
38	Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study. Coronary Artery Risk Development in Young Adults. (9590604)	Rathmann W.... Roseman J.M.	1998	INS
39	Contribution of a missense mutation (Trp64Arg) in beta3-adrenergic receptor gene to multiple risk factors in Japanese men with hyperuricemia. (10395234)	Hayashi H.... Saito T.	1998	ADRB3
40	The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice. (9002961)	Netea M.G.... Van der Meer J.W.	1997	IL1B, IL1A
41	Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study Investigators. (8637443)	Schmidt M.I.... Heiss G.	1996	INS
42	Hyperuricemia and xanthine oxidase in preeclampsia, revisited. (8572024)	Many A.... Roberts J.M.	1996	XDH
43	Hyperuricemia and insulin resistance (8976108)	Wasada T.... Iwatani M.	1996	INS
44	Hypertension and hyperuricemia (8976106)	Hirai A.... Saitoh Y.	1996	SERPINE1
45	Myogenic hyperuricemia: what can we learn from metabolic myopathies? (7603532)	Mineo I.... Tarui S.	1995	PFKM, AMPD3
46	Hyperuricemia (8009701)	Slot O.	1994	INS
47	Hyperuricemia and insulin resistance. (8288709)	Vuorinen-Markkola H.... Yki-JAorvinen H.	1994	INS
48	The role of hyperinsulinemia on the renal mechanism of hyperuricemia in overweight patients with essential hypertension (1813326)	Takada T.... Iimura O.	1991	INS
49	A genetic defect in muscle phosphofructokinase deficiency, a typical clinical entity presenting myogenic hyperuricemia. (1838230)	Nakajima H.... Noguchi T.	1991	PFKM
50	Lipid peroxidation and hyperuricemia in patients with ischemic heart disease (2395265)	Barats S.S.... Smolenskaia O.G.	1990	SOD1, GSR, CAT

Genes related to hyperuricemia according to GeneCards:

(show all 45)

id	Symbol	Description	Score	GeneCards Section Context
1	UMOD	uromodulin	11.1	Summaries, Publications
2	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.1	Publications, Summaries
3	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
4	MCKD2	medullary cystic kidney disease 2 (autosomal dominant)	11.0
5	SARS2	seryl-tRNA synthetase 2, mitochondrial	11.0	Publications
6	PFKM	phosphofructokinase, muscle	11.0	Publications
7	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Publications
8	ADRB3	adrenoceptor beta 3	11.0	Publications
9	XDH	xanthine dehydrogenase	11.0	Publications
10	GGT1	gamma-glutamyltransferase 1	11.0	Publications
11	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
12	INS	insulin	11.0	Publications
13	ZPBP2	zona pellucida binding protein 2	11.0	Publications
14	SLC2A6	solute carrier family 2 (facilitated glucose transporter), member 6	11.0	Publications
15	SARS	seryl-tRNA synthetase	11.0	Publications
16	MCAM	melanoma cell adhesion molecule	11.0	Publications
17	GPATCH8	G patch domain containing 8	11.0	Publications
18	CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	11.0	Publications
19	AMPD3	adenosine monophosphate deaminase 3	11.0	Publications
20	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
21	SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	11.0	Publications
22	LSL	Leptin, serum levels of	11.0	Publications
23	LIPC	lipase, hepatic	11.0	Publications
24	TYMS	thymidylate synthetase	11.0	Publications
25	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
26	CD40LG	CD40 ligand	11.0	Publications
27	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	UniProt Related
28	GSR	glutathione reductase	11.0	Publications
29	REN	renin	11.0	Publications
30	IL1A	interleukin 1, alpha	11.0	Publications
31	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
32	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
33	LPL	lipoprotein lipase	11.0	Publications
34	ADA	adenosine deaminase	11.0	Publications
35	TTR	transthyretin	11.0	Publications
36	SOD1	superoxide dismutase 1, soluble	11.0	Publications
37	CAT	catalase	11.0	Publications
38	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
39	LEP	leptin	11.0	Publications
40	CRP	C-reactive protein, pentraxin-related	11.0	Publications
41	IL1B	interleukin 1, beta	11.0	Publications
42	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
43	ALB	albumin	11.0	Publications
44	IL8	interleukin 8	11.0	Publications
45	TNF	tumor necrosis factor	11.0	Publications

Pathways related to hyperuricemia according to GeneDecks:

(show all 39)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.6	IL1A
2	NFAT Signaling and Lymphocyte Interactions36	10.4	IL1A, CACNA1S
3	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	10.1	MTHFR, HPRT1, TYMS, ADA
4	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.1	ADA, TYMS, MTHFR
5	Pathway_PA16598033734	10.1	SOD1, CAT, GSR
6	Oxidative Stress Pathway (Erythrocyte)34	10.1	SOD1, CAT, GSR
7	Oxidative Stress Pathway (Erythrocyte)34	10.1	SOD1, CAT, GSR
8	Adipocytokines & Insulin Signaling37	10.0	INS, LEP
9	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.0	ADA, TYMS, ABCG2, MTHFR
10	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	10.0	SOD1, ABCG2, CAT, XDH
11	Doxorubicin Pathway, Pharmacokinetics34	9.9	SOD1, ABCG2, CAT, XDH
12	Purine metabolism38	9.9	AMPD3, HPRT1, ADA
13	Selected targets of HNF110	9.6	CRP, ALB, INS, UMOD
14	Type I diabetes mellitus20	9.5	TNF, IL1B, IL1A, INS
15	Prion diseases20	9.3	IL1A, IL1B, IL6, SOD1
16	PGC1Alpha Pathway36	9.2	IL8, IL1B, IL1A
17	IL-10 Pathway36	9.1	TNF, IL6, IL1B, IL1A
18	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	IL1A, IL1B, IL6, TNF
19	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.9	TNF, IL6, IL1B, IL1A
20	SOCS Pathway36	8.9	INS, IL1A, IL1B, IL8
21	Metabolic pathways20	8.8	G6PC, G6PD, TYMS, ADA, GGT1, PFKM
22	Selected targets of GCR-alpha10	8.6	IL8, IL6, IL1B, INS, LEP
23	Immune response_MIF in innate immunity response41	8.5	TNF, IL8, IL6, IL1B
24	Immune response MIF in innate immunity response10	8.5	TNF, IL8, IL6, IL1B
25	Cytokine Network36	8.3	TNF, IL8, IL6, IL1B, IL1A
26	Pertussis20	8.3	TNF, IL8, IL6, IL1B, IL1A
27	NOD-like receptor signaling pathway20	8.3	IL1B, IL6, IL8, TNF
28	Rheumatoid arthritis20	8.3	TNF, IL8, IL6, IL1B, IL1A
29	Malaria20	8.2	SELP, CD40LG, IL1B, IL6, IL8, TNF
30	all-trans-Retinoic Acid Signaling in Brain36	8.2	CACNA1S, TNF, IL8, IL6, IL1B, IL1A
31	MIF Mediated Glucocorticoid Regulation36	8.2	TNF, IL8, IL6, IL1B, IL1A
32	MIF Regulation of Innate Immune Cells36	8.1	TNF, IL8, IL6, IL1B, IL1A
33	Chagas disease (American trypanosomiasis)20	8.1	TNF, IL8, IL6, IL1B, SERPINE1
34	PEDF Induced Signaling36	8.0	TNF, IL8, IL6, IL1B, IL1A
35	Immune response IL-1 signaling pathway10	8.0	TNF, IL8, IL6, IL1B, IL1A, SERPINE1
36	Immune response_IL-1 signaling pathway41	8.0	TNF, IL8, IL6, IL1B, IL1A, SERPINE1
37	Influenza A20	7.9	IL1A, IL1B, IL6, IL8, TNF
38	Cytokine-cytokine receptor interaction20	7.7	TNF, IL8, IL6, IL1B, IL1A, CD40LG
39	Antioxidant Action of Vitamin-C36	7.4	SLC2A6, SLC2A9, TNF, IL8, IL6, IL1B

Compounds related to hyperuricemia according to GeneDecks:

(show top 50)    (show all 364)

id	Compound	Score	Top Affiliating Genes
1	n acetylcysteine32	10.6	SELP, GPT
2	ivig32	10.3	CRP
3	hyaluronic acid32 18	11.3	TTR, GPT, GGT1
4	aspartate32	10.0	GSR, GGT1, SELP, CD40LG, G6PC
5	ascorbic acid32 18	11.0	CD40LG, IL1A, HPRT1, G6PD, TTR
6	pioglitazone32 9 9	11.7	LPL, LIPC, LEP, INS, GSR, GPT
7	h2o232	9.5	AMPD3, XDH, ADA, G6PC, HPRT1, LEP
8	mannitol32 9 9	11.4	CD40LG, G6PC, CAT, SOD1, GGT1, G6PD
9	hypoxanthine32 9 18 9	12.2	XDH, SOD1, TYMS, G6PD, HPRT1, CAT
10	pravastatin32 34 9 18 9	13.0	SERPINE1, SELP, ABCG2, LSL, CRP, IL6
11	mycophenolate mofetil32 9 9	11.0	SELP, SERPINE1, GGT1, HPRT1, GPT, CD40LG
12	glutamate32	9.0	GPT, GSR, AMPD3, MTHFR, LEP, HPRT1
13	bezafibrate32 9 9	11.0	CRP, GGT1, INS, LIPC, LPL, SERPINE1
14	testosterone32 9 18 9	11.9	LIPC, ABCG2, LSL, HPRT1, TTR, G6PD
15	atorvastatin32 34 9 18 9	12.9	SELP, CRP, LPL, CD40LG, GPT, TNF
16	malondialdehyde32	8.9	GSR, GPT, XDH, CRP, LSL, G6PC
17	vitamin b1232	8.8	TTR, ADA, GGT1, TYMS, G6PD, ALB
18	heparin32 9 18 9	11.7	LSL, ALB, UMOD, LIPC, LPL, SERPINE1
19	metformin32 34 9 9	11.7	LPL, INS, GPT, GGT1, MTHFR, LEP
20	epinephrine32 9 18 9	11.6	ADRB3, ADA, TTR, ABCG2, LSL, IL1A
21	betacarotene32	8.3	SOD1, HPRT1, CAT, LPL, LEP, MTHFR
22	folate32	8.2	ABCG2, TTR, TYMS, G6PD, CRP, HPRT1
23	adenylate32	8.2	CD40LG, HPRT1, ADRB3, ADA, TTR, TYMS
24	cyclosporin a32 42	9.0	IL1A, TTR, LEP, IL8, SELP, ABCG2
25	thyroxine32 18	9.0	LEP, CD40LG, INS, GSR, GPT, ALB
26	alpha tocopherol32	8.0	MTHFR, XDH, GSR, ALB, CAT, G6PD
27	rosiglitazone32 9 18 9	10.9	TNF, INS, LSL, IL6, LEP, CRP
28	losartan32 34 9 9	10.8	REN, SLC22A12, CRP, ALB, XDH, LEP
29	sulfasalazine32 9 9	9.8	IL1A, CRP, IL1B, TNF, IL8, ABCG2
30	arginine32	7.7	GSR, INS, CD40LG, XDH, LEP, LIPC
31	fenofibrate32 9 9	9.7	SELP, SERPINE1, LPL, LIPC, LEP, CD40LG
32	pdtc32	7.7	IL8, IL1A, IL6, CAT, TNF, SOD1
33	vitamin a32 9 18 9	10.6	GGT1, SOD1, TTR, CRP, HPRT1, CAT
34	creatinine32	7.5	LSL, G6PD, TYMS, TTR, SLC22A12, ADA
35	hydrocortisone32 9 9	9.4	IL1B, LSL, REN, IL1A, IL6, INS
36	norepinephrine32 9 18 9	10.3	REN, LPL, SELP, LEP, IL6, ADRB3
37	8-isoprostane32	7.1	SERPINE1, SOD1, LEP, XDH, INS, IL6
38	neopterin32	7.1	IL1A, IL1B, IL6, IL8, GPT, ADA
39	troglitazone32 42 9 9	10.0	LPL, LSL, TNF, SERPINE1, IL1B, IL8
40	alanine32	6.8	GPT, LSL, CD40LG, INS, GSR, IL6
41	fibrinogen32	6.6	LIPC, SERPINE1, SELP, TTR, INS, TNF
42	cholesterol32 9 18 9	9.4	SERPINE1, MTHFR, INS, IL6, GPT, ALB
43	indomethacin32 9 9	8.3	GSR, IL1A, IL1B, IL6, ALB, CAT
44	genistein32 9 18 9	9.3	ABCG2, TNF, IL8, CD40LG, IL6, IL1A
45	methotrexate32 34 42 9 9	10.1	SERPINE1, ABCG2, TYMS, ADA, GGT1, LSL
46	lipid32	5.5	ADRB3, SOD1, G6PD, CAT, TNF, CRP
47	dexamethasone32 42 34 9 9	9.4	GGT1, IL8, HPRT1, TNF, LSL, ABCG2
48	glucose32	INF	SLC2A9, AMPD3, UMOD, SLC2A6,
49	lactate32	INF	SELP, TNF, CRP, PFKM, LSL, G6PC
50	uric acid32 18	INF	SERPINE1, UMOD, LEP, MTHFR, G6PD, TTR

Cellular components related to hyperuricemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	9.2	SELP, CD40LG, MCAM, TNF, ADA
2	cytosol	GO:005829	7.2	HPRT1, PFKM, G6PD, TYMS, SOD1, ADA
3	extracellular region	GO:005576	5.4	IL8, ALB, CRP, TTR, SOD1, ZPBP2
4	extracellular space	GO:005615	4.1	REN, IL6, IL8, ALB, TNF, CRP

Biological processes related to hyperuricemia according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	urate metabolic process	GO:046415	10.3	ABCG2, G6PC, SLC2A9, SLC22A12
2	purine-containing compound salvage	GO:043101	10.3	ADA, HPRT1, AMPD3
3	seryl-tRNA aminoacylation	GO:006434	10.2	SARS2, SARS
4	glutathione metabolic process	GO:006749	10.1	GSR, G6PD, SOD1, GGT1
5	purine nucleobase metabolic process	GO:006144	10.0	ADA, HPRT1, CAT, AMPD3, XDH
6	positive regulation of cytokine secretion	GO:050715	9.8	TNF, IL1A, INS
7	fever generation	GO:001660	9.8	IL1B, IL1A
8	placenta development	GO:001890	9.8	LEP, SOD1, ADA
9	leukocyte tethering or rolling	GO:050901	9.8	SELP, LEP, TNF
10	defense response to Gram-negative bacterium	GO:050829	9.7	IL6, SERPINE1, SELP
11	negative regulation of lipid catabolic process	GO:050995	9.7	INS, IL1B, TNF
12	positive regulation of STAT protein import into nucleus	GO:2000366	9.7	LEP, IL6
13	positive regulation of MAPK cascade	GO:043410	9.7	LEP, INS, IL6, ADRB3
14	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IL1B
15	nucleobase-containing small molecule metabolic process	GO:055086	9.6	ADA, TYMS, HPRT1, CAT, AMPD3, GSR
16	positive regulation of cytokine production	GO:001819	9.6	SOD1, TNF, LEP
17	positive regulation of mitosis	GO:045840	9.5	INS, IL1A, IL1B, TNF
18	sequestering of triglyceride	GO:030730	9.5	TNF, IL1B
19	negative regulation of lipid storage	GO:010888	9.4	CRP, TNF, IL6
20	regulation of insulin secretion	GO:050796	9.2	TNF, IL1B, INS, LEP
21	chronic inflammatory response to antigenic stimulus	GO:002439	9.2	TNF, IL1B
22	embryonic digestive tract development	GO:048566	9.2	IL8, TNF, ADA
23	positive regulation of interleukin-6 production	GO:032755	9.1	TNF, IL6, IL1B, IL1A
24	platelet degranulation	GO:002576	9.1	SELP, SERPINE1, ALB, SOD1
25	response to drug	GO:042493	9.0	SLC22A12, SOD1, ABCG2, TNF, HTR2A, LPL
26	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.9	TNF, CAT, IL6, IL1B, INS
27	response to glucocorticoid stimulus	GO:051384	8.8	SERPINE1, IL1B, IL6, TNF
28	platelet activation	GO:030168	8.7	SELP, SERPINE1, CD40LG, IL6, ALB, SOD1
29	response to hypoxia	GO:001666	8.3	ADA, CRP, TNF, CAT, IL1B, IL1A
30	negative regulation of apoptotic process	GO:043066	8.0	TNF, CAT, ALB, IL6, INS, LEP
31	inflammatory response	GO:006954	7.6	CRP, TNF, IL8, IL6, IL1B, IL1A
32	transmembrane transport	GO:055085	INF	, SLC2A6, SLC22A12, SLC2A9, G6PC, ABCG2
33	small molecule metabolic process	GO:044281	INF	LPL, GGT1, ADA, , TYMS, G6PD
34	glucose transport	GO:015758	INF	, SLC2A6, SLC2A9, G6PC, INS
35	glucose metabolic process	GO:006006	INF	, PFKM, TNF, INS, LEP
36	glucose homeostasis	GO:042593	INF	, G6PC, INS, SERPINE1

Molecular functions related to hyperuricemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-tRNA ligase activity	GO:004828	10.3	SARS, SARS2
2	protein homodimerization activity	GO:042803	8.5	XDH, ADRB3, SOD1, G6PD, ABCG2, CRP
3	cytokine activity	GO:005125	8.3	TNF, IL6, IL1B, IL1A, CD40LG