MCID: HYP014
MIFTS: 56

Hyperuricemia malady

Blood diseases, Rare diseases categories
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Summaries for Hyperuricemia

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and lesch-nyhan syndrome. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Purine metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds benzbromarone and pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:65 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

hyperuricemia 8 10 45 62
blood urate raized 8
hyperuricaemia 8
uricacidaemia 8
uricacidemia 8


External Ids:

Disease Ontology8 DOID:1920
NCIt40 C3961
MeSH35 D033461
ICD1025 E79.0

Related Diseases for Hyperuricemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hyperuricemia family:

Hereditary Hyperuricemia

Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.5UMOD, HPRT1
2lesch-nyhan syndrome30.7HPRT1, XDH
3insulin resistance30.3FABP2, ADRB3, G6PC
4atherosclerosis30.2FABP2, ADRB3, XDH
5fatty liver disease30.2FABP2, ADRB3
6nephrolithiasis30.1SLC22A12, UMOD, HPRT1, XDH
7type 2 diabetes mellitus30.0G6PC, PFKM, ADRB3, FABP2
8diabetes mellitus30.0G6PC, PFKM, ADRB3, FABP2, UMOD
9familial juvenile hyperuricemic nephropathy29.9HPRT1, UMOD
10glycogen storage disease29.8G6PC, PFKM
11hypertriglyceridemia29.8G6PC, ADRB3, FABP2
12coronary artery disease29.8XDH, ADRB3, FABP2
13hypertension10.7
14kidney disease10.5
15obesity10.5
16endotheliitis10.4
17hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
18cystinuria10.2
19arthritis10.2
20blindness10.2
21nephronophthisis10.2
22essential hypertension10.2
23deafness hyperuricemia neurologic ataxia10.2
24hereditary hyperuricemia10.2
25psoriatic arthritis10.1
26acute myocardial infarction10.1
27hodgkin's lymphoma10.1
28leukemia10.1
29liver disease10.1
30myocardial infarction10.1
31athetosis10.1
32glycogen storage disease type 1a10.1
33nephropathy familial with hyperuricemia10.1
34renal hypouricemia10.1HPRT1, SLC22A12
35acute urate nephropathy10.0XDH, HPRT1
36developmental disabilities10.0HPRT1, G6PC
37hepatitis c10.0
38hemolytic-uremic syndrome10.0
39hepatitis10.0
40polycythemia10.0
41proteinuria10.0
42medullary cystic kidney disease type 110.0
43phosphoribosylpyrophosphate synthetase superactivity10.0
44umod-associated kidney disease10.0
45cardiovascular disease risk factor10.0
46erythrocytosis10.0
47glomerulocystic kidney disease with hyperuricemia and isosthenuria10.0
48hprt-related gout10.0
49autosomal dominant medullary cystic kidney disease with hyperuricemia10.0
50morbid obesity10.0FABP2, ADRB3

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Symptoms for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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33MalaCards
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MalaCards organs/tissues related to Hyperuricemia:

33
Kidney, Heart, Endothelial, Liver, Bone marrow, Testes, Thyroid, Breast, Myeloid, Bone, Cortex

Animal Models for Hyperuricemia or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Hyperuricemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2XDH, ADRB3, FABP2, UMOD
2MP:00053678.0XDH, G6PC, FABP2, HPRT1, UMOD, SLC22A12
3MP:00053867.8SLC22A12, HPRT1, ADRB3, PFKM, G6PC
4MP:00053797.7XDH, PFKM, ADRB3, HPRT1, SLC22A12
5MP:00053787.3XDH, G6PC, ADRB3, FABP2, HPRT1, UMOD
6MP:00053766.6SLC22A12, XDH, G6PC, PFKM, ADRB3, FABP2

Publications for Hyperuricemia

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Sources:
52PubMed
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Articles related to Hyperuricemia:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
2
Definition of hyperuricemia and gouty conditions. (24419750)
2014
3
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
4
Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. (23942050)
2013
5
Hyperuricemia is associated with hypertension, obesity, and albuminuria in children with chronic kidney disease. (22809658)
2013
6
The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study. (24308550)
2013
7
Mediterranean diet and risk of hyperuricemia in elderly participants at high cardiovascular risk. (23599357)
2013
8
Variation of urate transport in the nephrons in subtypes of hyperuricemia. (24052801)
2013
9
Hyperuricemia and non-dipping blood pressure. (24348063)
2013
10
Splenectomy is a risk factor for developing hyperuricemia and nephrolithiasis in patients with thalassemia intermedia: a retrospective study. (22705193)
2012
11
Hyperuricemia and metabolic syndrome in children with overweight and obesity. (23089370)
2012
12
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
13
Rasburicase in cancer-related hyperuricemia. (21850282)
2011
14
The prevalence of hyperuricemia in China: a meta-analysis. (22032610)
2011
15
Japanese guideline for the management of hyperuricemia and gout: second edition. (22132951)
2011
16
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (21654265)
2011
17
Lack of association between dietary fructose and hyperuricemia risk in adults. (20193069)
2010
18
Gout and hyperuricemia. (21229813)
2010
19
Association of urinary albumin excretion rate and hyperuricemia with macrovascular atherosclerosis in type 2 diabetic patients]. (20118005)
2010
20
A study of rasburicase for the management of hyperuricemia in pediatric patients with newly diagnosed hematologic malignancies at high risk for tumor lysis syndrome. (19701676)
2009
21
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
22
Efficacy and safety of losartan in treatment of hyperuricemia and posttransplantation erythrocytosis: results of a prospective, open, randomized, case-control study. (19917377)
2009
23
Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome. (18992978)
2009
24
Outcome of directly observed treatment short course (DOTS) in a case of pulmonary tuberculosis with hyperuricemia. (19810595)
2009
25
Hyperuricemia is associated with the development of the composite outcomes of new cardiovascular events and chronic allograft nephropathy. (18791445)
2008
26
The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. (17225053)
2007
27
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. (17190912)
2007
28
Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. (17396159)
2007
29
Prevalence of the metabolic syndrome in individuals with hyperuricemia. (17466656)
2007
30
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (16385546)
2006
31
Is hyperuricemia a cardiovascular risk factor?]. (17017483)
2006
32
Is hyperuricemia another facet of the metabolic syndrome? (16599014)
2006
33
Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. (16448895)
2006
34
Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children. (16911488)
2006
35
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. (16820043)
2006
36
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
37
Hyperuricemia and bone marrow transplantation. (15604610)
2005
38
The effect of alcoholic beverage type on hyperuricemia in Japanese male office workers. (15762093)
2005
39
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. (15824465)
2004
40
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
41
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. (15170929)
2004
42
Diuretic-induced hyperuricemia does not decrease cardiovascular risk. (15201561)
2004
43
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
44
Pathogenesis of hyperuricemia: recent advances. (12010614)
2002
45
Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. (11398134)
2001
46
Latent overproductive hyperuricemia increases in patients during the intermittent phase of gouty arthritis under long-term antihyperuricemic treatment. (24383630)
2000
47
Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. (10413068)
1999
48
Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. (10571797)
1999
49
Influence of hyperglycemia and hyperuricemia on long-term transplant survival in kidney transplant recipients. (10515217)
1999
50
Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report. (5495289)
1970

Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG
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Pathways related to Hyperuricemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC22A12, XDH
2
Show member pathways
purine deoxyribonucleosides degradation38
purine nucleotides degradation38
adenine and adenosine salvage II38
adenine and adenosine salvage III38
oxidized GTP and dGTP detoxification38
urate biosynthesis/inosine 5-phosphate degradation38
adenine and adenosine salvage I38
purine ribonucleosides degradation to ribose-1-phosphate38
inosine-5-phosphate biosynthesis38
guanosine nucleotides degradation38
guanine and guanosine salvage38
adenosine nucleotides degradation38
5-aminoimidazole ribonucleotide biosynthesis38
9.5HPRT1, XDH
3
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.2PFKM, G6PC
4
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I38
galactose degradation I (Leloir pathway)38
Cori Cycle38
9.2G6PC, PFKM
5
Show member pathways
9.1HPRT1, G6PC, XDH

Compounds for genes affiliated with Hyperuricemia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1benzbromarone4510.0SLC22A12, XDH
2pyrazinamide45 51 1112.0XDH, SLC22A12
36-thiouric acid4510.0HPRT1, XDH
42,8-dihydroxyadenine4510.0HPRT1, XDH
5tiazofurin459.9XDH, HPRT1
6mercaptopurine51 1110.9HPRT1, XDH
7didanosine45 51 1111.9HPRT1, XDH
8thiopurine459.9HPRT1, XDH
96 mercaptopurine459.9HPRT1, XDH
10probenecid29 45 61 51 1113.9XDH, SLC22A12
11purine nucleoside459.9XDH, HPRT1
12inosine45 2410.8XDH, HPRT1
13hypoxanthine45 24 1111.8HPRT1, XDH
14acetaldehyde29 45 2411.8HPRT1, XDH
15xanthine45 2410.7HPRT1, XDH
16succinate459.7HPRT1, G6PC
17peroxynitrite459.7UMOD, XDH
18galactose459.7UMOD, G6PC
19malondialdehyde459.6XDH, G6PC
20carvedilol45 51 29 1112.6ADRB3, XDH
21allopurinol45 51 1111.6XDH, HPRT1, UMOD
22losartan45 51 29 1112.6SLC22A12, XDH
23pyrophosphate45 2410.5HPRT1, SARS2, G6PC
24dmso459.5HPRT1, G6PC, XDH
25nadph45 2410.2XDH, G6PC, FABP2
26pyruvate459.0G6PC, PFKM, FABP2
27carnitine459.0SLC22A12, PFKM
28cysteine459.0UMOD, HPRT1, FABP2, XDH
29urea45 24 1111.0G6PC, ADRB3, FABP2, UMOD
30adenylate458.9G6PC, ADRB3, HPRT1
31lactate458.9PFKM, G6PC, XDH
32magnesium45 24 1110.8G6PC, PFKM, HPRT1, UMOD
33arginine458.8XDH, G6PC, ADRB3, HPRT1
34creatinine458.5SLC22A12, UMOD, HPRT1, FABP2, PFKM
35glycogen45 249.5G6PC, PFKM, ADRB3, FABP2
36fatty acid458.4FABP2, ADRB3, PFKM, G6PC
37alanine458.4FABP2, ADRB3, PFKM, G6PC
38uric acid45 249.2SLC22A12, UMOD, HPRT1, ADRB3, G6PC, XDH
39glucose458.1G6PC, PFKM, ADRB3, FABP2, UMOD
40lipid457.9XDH, G6PC, PFKM, ADRB3, FABP2

GO Terms for genes affiliated with Hyperuricemia

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16Gene Ontology
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Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.0SLC22A12, UMOD, PFKM

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1urate metabolic processGO:0464159.8SLC22A12, G6PC
2purine nucleobase metabolic processGO:0061449.6HPRT1, XDH
3nucleobase-containing small molecule metabolic processGO:0550869.4XDH, HPRT1
4glucose homeostasisGO:0425939.2PFKM, G6PC
5carbohydrate metabolic processGO:0059758.6ADRB3, PFKM, G6PC
6small molecule metabolic processGO:0442818.0HPRT1, PFKM, G6PC, XDH

Products for genes affiliated with Hyperuricemia

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  • Antibodies
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Sources for Hyperuricemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet