MCID: HYP014
MIFTS: 58

Hyperuricemia malady

Metabolic, Blood categories

Summaries for Hyperuricemia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and lesch-nyhan syndrome. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Galactose metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds potassium and 6 mercaptopurine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, cortex and heart, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Wikipedia:64 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic, Blood


Aliases & Descriptions:

hyperuricemia 8 10 45 61
blood urate raized 8
hyperuricaemia 8
uricacidaemia 8
uricacidemia 8


External Ids:

Disease Ontology8 DOID:1920
NCIt40 C3961
MeSH35 D033461
ICD1025 E79.0

Related Diseases for Hyperuricemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.3UMOD, HPRT1
2lesch-nyhan syndrome30.6HPRT1, XDH
3arthritis30.3HPRT1
4atherosclerosis30.3APOB, FABP2, XDH, INS, GGT1, ADRB3
5insulin resistance30.3GCK, HNF1B, APOB, FABP2, G6PC, INS
6fatty liver disease30.1GGT1, INS
7nephrolithiasis30.1UMOD, XDH, HPRT1, SLC22A12
8acute myocardial infarction30.1XDH, PIK3C2A, APOB
9coronary heart disease30.1APOB, FABP2, PIK3C2A, XDH, INS, GGT1
10glomerulocystic kidney disease with hyperuricemia and isosthenuria30.0UMOD, MCKD2
11umod-associated kidney disease30.0UMOD, MCKD2
12familial juvenile hyperuricemic nephropathy29.8HPRT1, UMOD, HNF1B
13acute kidney failure29.8UMOD, PIK3C2A, XDH, HPRT1, GPT, SLC22A12
14diabetic nephropathy29.8HNF1B, APOB, UMOD, INS, ADRB3
15hypercholesterolemia29.8APOB, FABP2, XDH, INS, GPT, GGT1
16coronary artery disease,29.8ADRB3, INS, PIK3C2A, APOB
17hypertriglyceridemia29.8APOB, FABP2, G6PC, INS, GPT, GGT1
18hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
19cystinuria10.2
20hereditary hyperuricemia10.2
21nephronophthisis10.2
22n syndrome10.2
23deafness hyperuricemia neurologic ataxia10.2
24psoriatic arthritis10.1
25adult syndrome10.1
26athetosis10.1
27glycogen storage disease type 1a10.1
28nephropathy familial with hyperuricemia10.1
29cardiovascular disease risk factor10.1
30hepatitis c10.0
31hemolytic-uremic syndrome10.0
32medullary cystic kidney disease type 110.0
33phosphoribosylpyrophosphate synthetase superactivity10.0
34erythrocytosis10.0
35hprt-related gout10.0
36autosomal dominant medullary cystic kidney disease with hyperuricemia10.0
37pyelonephritis10.0UMOD
38acute pancreatitis10.0GPT
39metabolic acidosis10.0PIK3C2A
40blindness10.0INS
41hyperandrogenism10.0INS
42gallbladder disease10.0GGT1
43pneumonia10.0PIK3C2A, XDH
44nephrotic syndrome10.0APOB
45colorectal cancer10.0XDH
46infertility10.0INS
47uromodulin-associated kidney disease10.0UMOD, MCKD2
48acute urate nephropathy10.0XDH, HPRT1
49renal hypouricemia10.0HPRT1, SLC22A12
50myocardial infarction10.0PIK3C2A, APOB

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Clinical Features for Hyperuricemia

Drugs & Therapeutics for Hyperuricemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hyperuricemia

Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Search CenterWatch for Hyperuricemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hyperuricemia

Anatomical Context for Hyperuricemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hyperuricemia:

33
Bone marrow, Cortex, Heart, Kidney, Liver, Thyroid, Breast, Myeloid, B cells, Endothelial, Pancreatic islet

Animal Models for Hyperuricemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hyperuricemia

Sources:
51PubMed
See all sources

Articles related to Hyperuricemia:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
2
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
3
Hyperuricemia and non-dipping blood pressure. (24348063)
2013
4
The kidney in hyperuricemia and gout. (23318701)
2013
5
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. (23620537)
2013
6
Comparative physiology and hyperuricemia as a causal factor for hypertension. (23804295)
2013
7
The effect of allopurinol on lowering blood pressure in hemodialysis patients with hyperuricemia. (23833578)
2012
8
Management of gout: a 57-year-old man with a history of podagra, hyperuricemia, and mild renal insufficiency. (23188030)
2012
9
Hyperuricemia in adult renal allograft recipients: prevalence and predictors. (23026595)
2012
10
The prevalence of hyperuricemia in China: a meta-analysis. (22032610)
2011
11
Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD. (21903317)
2011
12
Hyperuricemia accompanied with changes in the retinal microcirculation in a Chinese high-risk population for diabetes. (21565686)
2011
13
MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction. (21258895)
2011
14
Hyperuricemia and its association with carotid intima-media thickness in hypertensive and non hypertensive patients. (23960588)
2010
15
Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome. (21589837)
2010
16
A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia. (21116779)
2010
17
Effect of serum insulin on the association between hyperuricemia and incident heart failure. (20920653)
2010
18
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
19
Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. (19605544)
2009
20
Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension. (19919398)
2009
21
Prevalence of gout and hyperuricemia in Taiwan: a hospital-based, cross-sectional study. (19488006)
2009
22
Relationship between hyperuricemia and metabolic syndrome]. (18409529)
2008
23
Assessment of left ventricular systolic and diastolic function by tissue Doppler analysis in patients with hypertension with or without hyperuricemia. (18347441)
2008
24
The conundrum of hyperuricemia, metabolic syndrome, and renal disease. (18320146)
2008
25
Update on the management of hyperuricemia and gout. (18937638)
2008
26
Relationship between hyperuricemia and metabolic syndrome. (17657863)
2007
27
Hyperuricemia and incidence of hypertension among men without metabolic syndrome. (17190877)
2007
28
Is hyperuricemia another facet of the metabolic syndrome? (16599014)
2006
29
Marked hyperuricemia with acute renal failure: need to consider occult malignancy and spontaneous tumour lysis syndrome. (16494656)
2006
30
Hyperuricemia as a risk factor for contrast-induced nephropathy in patients with chronic kidney disease. (16400673)
2006
31
What do epidemiologic studies tell us about hyperuricemia and cardiovascular disease and death? (15918997)
2005
32
Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions. (15604604)
2005
33
Hyperuricemia induces endothelial dysfunction. (15840020)
2005
34
High prevalence of hyperuricemia in elderly Taiwanese. (16169841)
2005
35
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
36
Hyperuricemia, low urine urate excretion and target organ damage in arterial hypertension. (14763658)
2003
37
Incidence, medical resource utilisation and costs of hyperuricemia and tumour lysis syndrome in patients with acute leukaemia and non-Hodgkin's lymphoma in four European countries. (12691145)
2003
38
Prevention and treatment of hyperuricemia in hematological malignancies. (12521386)
2002
39
Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes. (11298778)
2001
40
Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient. (11177768)
2001
41
Etiology of third-trimester maternal hyperuricemia in nonpreeclamptic twin gestations. (11294176)
2001
42
Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial. (11587206)
2001
43
Epidemiology of hyperuricemia in the elderly. (11501710)
2001
44
Role of cyclosporine in inducing hyperuricemia in heart transplant patients. (10856561)
2000
45
Gout and hyperuricemia. (10068714)
1999
46
Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans? (10522560)
1999
47
Broadsheet number 43: The role of the laboratory in the investigation and management of hyperuricemia. (9643491)
1998
48
A genetic defect in muscle phosphofructokinase deficiency, a typical clinical entity presenting myogenic hyperuricemia. (1838230)
1991
49
Antepartum thrombophlebitis complicated by hyperuricemia, uremia, and polyhydramnios. (4896448)
1969
50
Cystinuria with hyperuricemia and methioninuria. Biochemical study of a case. (4951411)
1967

Genetic Variations for Hyperuricemia

Expression for genes affiliated with Hyperuricemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

Sources:
50PharmGKB, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Hyperuricemia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1potassium45 11 2412.7GCK, PIK3C2A, ADRB3
26 mercaptopurine4510.7XDH, HPRT1, GPT
3glucose4510.7GCK, HNF1B, UMOD, PIK3C2A, PFKM
4niacin45 1111.7APOB, HPRT1, INS, GPT
5nash4510.7INS, GPT, GGT1
6gemfibrozil45 29 1112.6GPT, INS, PIK3C2A, APOB
76-thiouric acid4510.6HPRT1, XDH
8carnitine4510.6SLC22A12, INS, PFKM, APOB
9allopurinol45 50 1112.6HPRT1, XDH, UMOD
10mannitol45 1111.6GGT1, G6PC, GCK
11malondialdehyde4510.6G6PC, PIK3C2A, XDH, GPT, GGT1
12fenofibrate45 50 1112.6APOB, FABP2, PIK3C2A, INS, GPT
13azathioprine45 50 2 1113.6XDH, HPRT1, GPT, GGT1
14pioglitazone45 50 29 1113.6GGT1, GPT, INS, APOB
15metformin45 50 1112.6GGT1, GPT, INS, APOB, GCK
16bezafibrate45 29 1112.6APOB, PIK3C2A, INS, GPT, GGT1
172,8-dihydroxyadenine4510.6HPRT1, XDH
18h2o24510.6GCK, G6PC, HPRT1
191-nitropyrene4510.6GGT1, HPRT1
20vitamin a45 11 2412.6GGT1, GPT, HPRT1, FABP2, APOB
21ezetimibe45 1111.6APOB, INS, GPT
22isoflurane45 1111.6PIK3C2A, GPT, GGT1
23haloperidol45 29 2 50 1114.6GGT1, GPT, PIK3C2A, APOB
24pyruvate4510.6GCK, FABP2, G6PC, PIK3C2A, PFKM, GPT
25thyroxine45 2411.6APOB, PIK3C2A, INS, GPT, GGT1
26urea45 11 2412.6FABP2, UMOD, G6PC, PIK3C2A, GPT, GGT1
27lovastatin45 50 60 29 1114.6GGT1, GPT, PIK3C2A, APOB
28glutamine4510.5GCK, APOB, G6PC, HPRT1, GPT, GGT1
29pyrophosphate45 2411.5SARS2, SARS, G6PC, PIK3C2A, HPRT1
30adenylate4510.5GCK, APOB, G6PC, HPRT1, GPT, ADRB3
31glycogen45 2411.5GCK, FABP2, G6PC, PIK3C2A, PFKM, INS
32dexamethasone45 50 29 1113.5GCK, APOB, G6PC, HPRT1, INS, GGT1
33fatty acid4510.5GCK, APOB, FABP2, G6PC, PIK3C2A, PFKM
34magnesium45 11 2412.5GCK, UMOD, G6PC, PIK3C2A, PRPS1L1, HPRT1
35rosuvastatin45 50 29 1113.5GPT, INS, APOB
36adenine45 11 2412.4APOB, XDH, HPRT1, GGT1
37glutamate4510.4GCK, APOB, G6PC, PIK3C2A, HPRT1, INS
38lactate4510.4GCK, APOB, G6PC, PIK3C2A, XDH, PFKM
39policosanol4510.4GPT, PIK3C2A
40arginine4510.4GCK, HNF1B, G6PC, PIK3C2A, XDH, HPRT1
41cholesterol45 29 11 2413.4GCK, HNF1B, APOB, FABP2, G6PC, PIK3C2A
42chromium picolinate4510.4INS, GCK
43alanine4510.4GCK, APOB, FABP2, G6PC, PIK3C2A, PFKM
44creatinine4510.4UMOD, FABP2, APOB, GCK, PIK3C2A, HPRT1
45choline45 11 2412.3APOB, PIK3C2A, GPT, GGT1
46uric acid45 2411.3ADRB3, HNF1B, APOB, UMOD, G6PC, PIK3C2A
47lipid4510.3G6PC, FABP2, APOB, GCK, PIK3C2A, XDH
48silymarin4510.3GGT1, GPT, XDH
49aicar45 11 2412.2GCK, G6PC, INS
50phosphorus4510.0GGT1, GPT, PIK3C2A

GO Terms for genes affiliated with Hyperuricemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:03190410.4INS, APOB

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1seryl-tRNA aminoacylationGO:00643410.6SARS, SARS2
2selenocysteinyl-tRNA(Sec) biosynthetic processGO:09705610.5SARS, SARS2
3glucose homeostasisGO:04259310.5GCK, G6PC, PFKM, INS
4endocrine pancreas developmentGO:03101810.5GCK, HNF1B, INS
5glucose transportGO:01575810.4GCK, G6PC, INS
6negative regulation of gluconeogenesisGO:04572110.4INS, GCK
7urate metabolic processGO:04641510.4G6PC, SLC22A12
8carbohydrate metabolic processGO:00597510.3ADRB3, PFKM, G6PC, GCK
9positive regulation of glycolysisGO:04582110.3GCK, INS
10small molecule metabolic processGO:04428110.2GGT1, GCK, APOB, G6PC, PIK3C2A, XDH
11positive regulation of glycogen biosynthetic processGO:04572510.1INS, GCK

Molecular functions related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.2ADRB3, HPRT1, XDH, PRPS1L1, HNF1B
2serine-tRNA ligase activityGO:00482810.1SARS, SARS2

Products for genes affiliated with Hyperuricemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyperuricemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet