MCID: HYP014
MIFTS: 61

Hyperuricemia malady

Metabolic diseases, Blood diseases categories

Summaries for Hyperuricemia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and hypertension. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Galactose metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds potassium and 6 mercaptopurine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Wikipedia:63 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Blood diseases


Aliases & Descriptions:

hyperuricemia 8 10 44 60
blood urate raized 8
hyperuricaemia 8
uricacidaemia 8
uricacidemia 8


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Disease Ontology8 DOID:1920
NCIt39 C3961
MeSH34 D033461
ICD1025 E79.0

Related Diseases for Hyperuricemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.3UMOD, HPRT1
2hypertension30.9ADRB3, GGT1, INS, APOB
3obesity30.6GCK, APOB, FABP2, INS, GPT, GGT1
4lesch-nyhan syndrome30.6HPRT1, XDH
5arthritis30.3HPRT1
6atherosclerosis30.3APOB, FABP2, XDH, INS, GGT1, ADRB3
7essential hypertension30.2ADRB3, INS, XDH, APOB
8myocardial infarction30.1PIK3C2A, APOB
9fatty liver disease30.1GGT1, INS
10nephrolithiasis30.1UMOD, XDH, HPRT1, SLC22A12
11acute myocardial infarction30.1XDH, PIK3C2A, APOB
12type 2 diabetes mellitus30.1ADRB3, GGT1, GPT, INS, PFKM, G6PC
13diabetes mellitus30.1GCK, HNF1B, ADRB3, GGT1, GPT, INS
14glomerulocystic kidney disease with hyperuricemia and isosthenuria30.0UMOD, MCKD2
15umod-associated kidney disease30.0UMOD, MCKD2
16hepatitis30.0GGT1, GPT, XDH
17proteinuria30.0GGT1, INS, PIK3C2A, UMOD, APOB
18malaria29.9XDH, HPRT1
19familial juvenile hyperuricemic nephropathy29.7HPRT1, UMOD, HNF1B
20pancreatitis29.7GGT1, INS
21glomerulonephritis29.7XDH, UMOD
22hypothyroidism29.7APOB, PIK3C2A, INS
23acute kidney failure29.7UMOD, PIK3C2A, XDH, HPRT1, GPT, SLC22A12
24diabetic nephropathy29.7HNF1B, APOB, UMOD, INS, ADRB3
25myopathy29.7PIK3C2A, PFKM, INS, GPT
26hyperglycemia29.7GCK, HNF1B, APOB, G6PC, INS, ADRB3
27galactosemia29.7HNF1B, APOB, INS, GPT, GGT1
28cystic kidney29.7HNF1B, UMOD
29coronary artery disease29.7ADRB3, INS, PIK3C2A, APOB
30chronic kidney failure29.7INS, UMOD, APOB, HNF1B
31glycogen storage disease29.7G6PC, PFKM
32kidney disease10.5
33renal hypertension10.2
34hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.2
35cystinuria10.2
36nephronophthisis10.1
37deafness hyperuricemia neurologic ataxia10.1
38psoriatic arthritis10.1
39adult syndrome10.1
40hodgkin's lymphoma10.1
41leukemia10.1
42liver disease10.1
43medullary cystic kidney disease type 110.1
44glycogen storage disease type 1a10.1
45hereditary hyperuricemia10.1
46nephropathy familial with hyperuricemia10.1
47hepatitis c10.0
48hemolytic-uremic syndrome10.0
49ischemic heart disease10.0
50polycythemia10.0

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Clinical Features for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperuricemia

Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Search CenterWatch for Hyperuricemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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32MalaCards
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MalaCards organs/tissues related to Hyperuricemia:

32
Kidney, Heart, Endothelial, Liver, Cortex, Bone, Thyroid, Breast, Testes, Myeloid, Bone marrow

Animal Models for Hyperuricemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperuricemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.3SLC22A12, GCK, HNF1B, FABP2, UMOD, G6PC
2MP:000537010.1GCK, HNF1B, APOB, FABP2, G6PC, HPRT1
3MP:000537510.1FABP2, UMOD, PIK3C2A, XDH, INS, ADRB3
4MP:000539710.1UMOD, PIK3C2A, HPRT1, PFKM, INS, SLC22A12
5MP:000537910.0GCK, HNF1B, ZPBP2, XDH, HPRT1, PFKM
6MP:00053789.9GCK, HNF1B, APOB, FABP2, UMOD, G6PC
7MP:00053769.9G6PC, UMOD, FABP2, APOB, HNF1B, GCK
8MP:00107689.6GCK, HNF1B, APOB, G6PC, PIK3C2A, XDH

Publications for Hyperuricemia

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Sources:
50PubMed
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Articles related to Hyperuricemia:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Hyperuricemia and the risk of ischemic stroke in patients with atrial fibrillation - Could it refine clinical risk stratification in AF? (24290426)
2014
2
Trp64Arg (rs4994) polymorphism of I^3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population. (23729572)
2013
3
Hyperuricemia in pediatric renal transplant recipients. (24344940)
2013
4
Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. (23866159)
2013
5
Hyperuricemia after exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans near a highly contaminated area. (23676268)
2013
6
Hyperuricemia is independently associated with coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus. (22125626)
2011
7
Effects of dairy intake on hyperuricemia and gout. (21188562)
2011
8
Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia. (21622823)
2011
9
Relationship between hyperuricemia and chronic kidney disease. (22132954)
2011
10
Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study. (21654268)
2011
11
Rasburicase for hyperuricemia in an extremely low birth weight infant. (21813935)
2011
12
Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study. (21241475)
2011
13
Hyperuricemia after renal transplantation. (21440768)
2011
14
Dietary intake and the risk of hyperuricemia, gout and chronic kidney disease in elderly Taiwanese men. (20849370)
2011
15
Association of urinary albumin excretion rate and hyperuricemia with macrovascular atherosclerosis in type 2 diabetic patients]. (20118005)
2010
16
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. (20370912)
2010
17
Advances in the management of gout: critical appraisal of febuxostat in the control of hyperuricemia. (21694922)
2010
18
Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia. (20653406)
2010
19
Management of hyperuricemia in gout: focus on febuxostat. (20169038)
2010
20
New agents for the treatment of gout and hyperuricemia: febuxostat, puricase, and beyond. (20425022)
2010
21
Gout Study Group: update on hyperuricemia and gout. (19559637)
2009
22
Hyperuricemia, gout, and cardiovascular disease--an important "muddle". (19852752)
2009
23
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. (19008712)
2008
24
Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. (18420362)
2008
25
Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia. (18695387)
2008
26
Primary hyperuricemia due to decreased renal uric acid excretion]. (18409514)
2008
27
The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. (17225053)
2007
28
Drug discovery for hyperuricemia. (23496132)
2007
29
A concise history of gout and hyperuricemia and their treatment. (16820040)
2006
30
Hyperuricemia treatment: is creatinine clearance a safer allopurinol dosing meter than plasma creatinine levels? (16932657)
2006
31
Genetic factors associated with gout and hyperuricemia. (16580613)
2006
32
Reduced-dose rasburicase (recombinant xanthine oxidase) in adult cancer patients with hyperuricemia. (16708061)
2006
33
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
34
Hyperuricemia and bone marrow transplantation. (15604610)
2005
35
A single dose of rasburicase is sufficient for the treatment of hyperuricemia in patients receiving chemotherapy. (15725482)
2005
36
Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. (15660334)
2005
37
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. (15824465)
2004
38
Prevalence of comorbid conditions and prescription medication use among patients with gout and hyperuricemia in a managed care setting. (17043538)
2004
39
Successful treatment of hyperuricemia with low doses of recombinant urate oxidase in four patients with hematologic malignancy and tumor lysis syndrome. (14523460)
2003
40
Hyperuricemia in childhood primary hypertension. (12900431)
2003
41
Hyperuricemia as a prognostic factor in pulmonary arterial hypertension. (12587962)
2003
42
Rasburicase for the treatment and prevention of hyperuricemia. (12841818)
2003
43
High prevalence of hyperuricemia in adolescent Taiwan aborigines. (11950030)
2002
44
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. (11997315)
2002
45
Hyperuricemia and gout in thyroid endocrine disorders. (11791637)
2001
46
Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers. (11210110)
2000
47
Hyperuricemia in severe pulmonary hypertension. (10631193)
2000
48
The epidemiology study of hyperuricemia and gout in a community population of Huangpu District in Shanghai. (10374422)
1998
49
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies. (9369411)
1997
50
Hyperuricemia and insulin resistance]. (8976108)
1996

Genetic Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Hyperuricemia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1potassium44 11 2412.7GCK, PIK3C2A, ADRB3
26 mercaptopurine4410.7XDH, HPRT1, GPT
3glucose4410.7GCK, HNF1B, UMOD, PIK3C2A, PFKM
4niacin44 1111.7APOB, HPRT1, INS, GPT
5nash4410.7INS, GPT, GGT1
6gemfibrozil44 28 1112.6GPT, INS, PIK3C2A, APOB
76-thiouric acid4410.6HPRT1, XDH
8carnitine4410.6SLC22A12, INS, PFKM, APOB
9allopurinol44 49 1112.6HPRT1, XDH, UMOD
10mannitol44 1111.6GGT1, G6PC, GCK
11malondialdehyde4410.6G6PC, PIK3C2A, XDH, GPT, GGT1
12fenofibrate44 49 1112.6APOB, FABP2, PIK3C2A, INS, GPT
13azathioprine44 49 2 1113.6XDH, HPRT1, GPT, GGT1
14pioglitazone44 49 28 1113.6GGT1, GPT, INS, APOB
15metformin44 49 1112.6GGT1, GPT, INS, APOB, GCK
16bezafibrate44 28 1112.6APOB, PIK3C2A, INS, GPT, GGT1
172,8-dihydroxyadenine4410.6HPRT1, XDH
18h2o24410.6GCK, G6PC, HPRT1
191-nitropyrene4410.6GGT1, HPRT1
20vitamin a44 11 2412.6GGT1, GPT, HPRT1, FABP2, APOB
21ezetimibe44 1111.6APOB, INS, GPT
22isoflurane44 1111.6PIK3C2A, GPT, GGT1
23haloperidol44 28 2 49 1114.6GGT1, GPT, PIK3C2A, APOB
24pyruvate4410.6GCK, FABP2, G6PC, PIK3C2A, PFKM, GPT
25thyroxine44 2411.6APOB, PIK3C2A, INS, GPT, GGT1
26urea44 11 2412.6FABP2, UMOD, G6PC, PIK3C2A, GPT, GGT1
27lovastatin44 49 59 28 1114.6GGT1, GPT, PIK3C2A, APOB
28glutamine4410.5GCK, APOB, G6PC, HPRT1, GPT, GGT1
29pyrophosphate44 2411.5SARS2, SARS, G6PC, PIK3C2A, HPRT1
30adenylate4410.5GCK, APOB, G6PC, HPRT1, GPT, ADRB3
31glycogen44 2411.5GCK, FABP2, G6PC, PIK3C2A, PFKM, INS
32dexamethasone44 49 28 1113.5GCK, APOB, G6PC, HPRT1, INS, GGT1
33fatty acid4410.5GCK, APOB, FABP2, G6PC, PIK3C2A, PFKM
34magnesium44 11 2412.5GCK, UMOD, G6PC, PIK3C2A, PRPS1L1, HPRT1
35rosuvastatin44 49 28 1113.5GPT, INS, APOB
36adenine44 11 2412.4APOB, XDH, HPRT1, GGT1
37glutamate4410.4GCK, APOB, G6PC, PIK3C2A, HPRT1, INS
38lactate4410.4GCK, APOB, G6PC, PIK3C2A, XDH, PFKM
39policosanol4410.4GPT, PIK3C2A
40arginine4410.4GCK, HNF1B, G6PC, PIK3C2A, XDH, HPRT1
41cholesterol44 28 11 2413.4GCK, HNF1B, APOB, FABP2, G6PC, PIK3C2A
42chromium picolinate4410.4INS, GCK
43alanine4410.4GCK, APOB, FABP2, G6PC, PIK3C2A, PFKM
44creatinine4410.4UMOD, FABP2, APOB, GCK, PIK3C2A, HPRT1
45choline44 11 2412.3APOB, PIK3C2A, GPT, GGT1
46uric acid44 2411.3ADRB3, HNF1B, APOB, UMOD, G6PC, PIK3C2A
47lipid4410.3G6PC, FABP2, APOB, GCK, PIK3C2A, XDH
48silymarin4410.3GGT1, GPT, XDH
49aicar44 11 2412.2GCK, G6PC, INS
50phosphorus4410.0GGT1, GPT, PIK3C2A

GO Terms for genes affiliated with Hyperuricemia

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16Gene Ontology
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Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:03190410.4INS, APOB

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1seryl-tRNA aminoacylationGO:00643410.6SARS, SARS2
2selenocysteinyl-tRNA(Sec) biosynthetic processGO:09705610.5SARS, SARS2
3glucose homeostasisGO:04259310.5GCK, G6PC, PFKM, INS
4endocrine pancreas developmentGO:03101810.5GCK, HNF1B, INS
5glucose transportGO:01575810.4GCK, G6PC, INS
6negative regulation of gluconeogenesisGO:04572110.4INS, GCK
7urate metabolic processGO:04641510.4G6PC, SLC22A12
8carbohydrate metabolic processGO:00597510.3ADRB3, PFKM, G6PC, GCK
9positive regulation of glycolysisGO:04582110.3GCK, INS
10small molecule metabolic processGO:04428110.2GGT1, GCK, APOB, G6PC, PIK3C2A, XDH
11positive regulation of glycogen biosynthetic processGO:04572510.1INS, GCK

Molecular functions related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.2ADRB3, HPRT1, XDH, PRPS1L1, HNF1B
2serine-tRNA ligase activityGO:00482810.1SARS, SARS2

Products for genes affiliated with Hyperuricemia

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  • Antibodies
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Sources for Hyperuricemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet