MCID: HYP014
MIFTS: 61

Hyperuricemia malady

Metabolic diseases, Blood diseases categories

Summaries for Hyperuricemia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards: Hyperuricemia, also known as blood urate raized, is related to gout and hypertension. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Galactose metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds potassium and 6 mercaptopurine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Wikipedia:63 Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of... more...

Aliases & Classifications for Hyperuricemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Blood diseases


Aliases & Descriptions:

hyperuricemia 8 10 44 60
blood urate raized 8
hyperuricaemia 8
uricacidaemia 8
uricacidemia 8


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Disease Ontology8 DOID:1920
NCIt39 C3961
MeSH34 D033461
ICD1025 E79.0

Related Diseases for Hyperuricemia

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17GeneCards, 18GeneDecks
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Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.3UMOD, HPRT1
2hypertension30.9ADRB3, GGT1, INS, APOB
3obesity30.6GCK, APOB, FABP2, INS, GPT, GGT1
4lesch-nyhan syndrome30.6HPRT1, XDH
5arthritis30.3HPRT1
6atherosclerosis30.3APOB, FABP2, XDH, INS, GGT1, ADRB3
7essential hypertension30.2ADRB3, INS, XDH, APOB
8myocardial infarction30.1PIK3C2A, APOB
9fatty liver disease30.1GGT1, INS
10nephrolithiasis30.1UMOD, XDH, HPRT1, SLC22A12
11acute myocardial infarction30.1XDH, PIK3C2A, APOB
12type 2 diabetes mellitus30.1ADRB3, GGT1, GPT, INS, PFKM, G6PC
13diabetes mellitus30.1GCK, HNF1B, ADRB3, GGT1, GPT, INS
14glomerulocystic kidney disease with hyperuricemia and isosthenuria30.0UMOD, MCKD2
15umod-associated kidney disease30.0UMOD, MCKD2
16hepatitis30.0GGT1, GPT, XDH
17proteinuria30.0GGT1, INS, PIK3C2A, UMOD, APOB
18malaria29.9XDH, HPRT1
19familial juvenile hyperuricemic nephropathy29.7HPRT1, UMOD, HNF1B
20pancreatitis29.7GGT1, INS
21glomerulonephritis29.7XDH, UMOD
22hypothyroidism29.7APOB, PIK3C2A, INS
23acute kidney failure29.7UMOD, PIK3C2A, XDH, HPRT1, GPT, SLC22A12
24diabetic nephropathy29.7HNF1B, APOB, UMOD, INS, ADRB3
25myopathy29.7PIK3C2A, PFKM, INS, GPT
26hyperglycemia29.7GCK, HNF1B, APOB, G6PC, INS, ADRB3
27galactosemia29.7HNF1B, APOB, INS, GPT, GGT1
28cystic kidney29.7HNF1B, UMOD
29coronary artery disease29.7ADRB3, INS, PIK3C2A, APOB
30chronic kidney failure29.7INS, UMOD, APOB, HNF1B
31glycogen storage disease29.7G6PC, PFKM
32kidney disease10.5
33renal hypertension10.2
34hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.2
35cystinuria10.2
36nephronophthisis10.1
37deafness hyperuricemia neurologic ataxia10.1
38psoriatic arthritis10.1
39adult syndrome10.1
40hodgkin's lymphoma10.1
41leukemia10.1
42liver disease10.1
43medullary cystic kidney disease type 110.1
44glycogen storage disease type 1a10.1
45hereditary hyperuricemia10.1
46nephropathy familial with hyperuricemia10.1
47hepatitis c10.0
48hemolytic-uremic syndrome10.0
49ischemic heart disease10.0
50polycythemia10.0

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Clinical Features for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyperuricemia

Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Search CenterWatch for Hyperuricemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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32MalaCards
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MalaCards organs/tissues related to Hyperuricemia:

32
Kidney, Heart, Endothelial, Liver, Cortex, Bone, Thyroid, Breast, Testes, Myeloid, Bone marrow

Animal Models for Hyperuricemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyperuricemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.3SLC22A12, GCK, HNF1B, FABP2, UMOD, G6PC
2MP:000537010.1GCK, HNF1B, APOB, FABP2, G6PC, HPRT1
3MP:000537510.1FABP2, UMOD, PIK3C2A, XDH, INS, ADRB3
4MP:000539710.1UMOD, PIK3C2A, HPRT1, PFKM, INS, SLC22A12
5MP:000537910.0GCK, HNF1B, ZPBP2, XDH, HPRT1, PFKM
6MP:00053789.9GCK, HNF1B, APOB, FABP2, UMOD, G6PC
7MP:00053769.9G6PC, UMOD, FABP2, APOB, HNF1B, GCK
8MP:00107689.6GCK, HNF1B, APOB, G6PC, PIK3C2A, XDH

Publications for Hyperuricemia

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Sources:
50PubMed
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Articles related to Hyperuricemia:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Mediterranean diet and risk of hyperuricemia in elderly participants at high cardiovascular risk. (23599357)
2013
2
Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. (23970726)
2013
3
Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. (23899832)
2013
4
Metabolic syndrome, diabetes, and hyperuricemia. (23370374)
2013
5
Hyperuricemia is an independent risk factor for mortality only if chronic kidney disease is present. (23615329)
2013
6
Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. (23673972)
2013
7
Hyperuricemia and metabolic syndrome in children with overweight and obesity. (23089370)
2012
8
Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study. (22753829)
2012
9
Hyperuricemia, gout and the kidney. (22157498)
2012
10
The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions. (23253231)
2012
11
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia. (23122864)
2012
12
Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. (21095025)
2012
13
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
14
Rasburicase in cancer-related hyperuricemia. (21850282)
2011
15
Joint association of hyperuricemia and reduced GFR on cardiovascular morbidity: a historical cohort study based on laboratory and claims data from a national insurance provider. (21783292)
2011
16
Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in man. (22132949)
2011
17
Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (21654266)
2011
18
Treating hyperuricemia of gout: safety and efficacy of febuxostat and allopurinol in older versus younger subjects. (22132950)
2011
19
Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. (21255763)
2011
20
An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study. (21654269)
2011
21
Hyperuricemia in non-alcoholic fatty liver disease. (21933215)
2011
22
Investigation on hyperuricemia in children with obesity or various pediatric disorders. (22132956)
2011
23
Sugar-sweetened soda consumption, hyperuricemia, and kidney disease. (20842151)
2010
24
Differences in MSU-induced superoxide responses by neutrophils from gout subjects compared to healthy controls and a role for environmental inflammatory cytokines and hyperuricemia in neutrophil function and survival. (20395644)
2010
25
The role of hyperuricemia in vascular disorders. (19339923)
2009
26
A sugar transporter regulates serum urate levels: implications for prevention and management of hyperuricemia in gout. (19296879)
2009
27
Introduction: hyperuricemia and gout. (19999891)
2009
28
Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. (19664745)
2009
29
Management of hyperuricemia and gout in CKD. (18971014)
2008
30
Dietary factors associated with hyperuricemia in adults. (17570471)
2008
31
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. (18701632)
2008
32
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. (16820043)
2006
33
Reduced-dose rasburicase in the treatment of adults with hyperuricemia associated with malignancy. (16466328)
2006
34
An analysis of islet beta-cell function in hyperuricemia]. (16831320)
2006
35
Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study. (16154134)
2005
36
Hemodynamics of hyperuricemia. (15660330)
2005
37
Managing malignancy-associated hyperuricemia with rasburicase. (15796443)
2005
38
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. (15170929)
2004
39
Pyrazinamide induced hyperuricemia in patients taking anti-tuberculous therapy. (15228843)
2004
40
Recombinant urate oxidase for prevention of hyperuricemia and tumor lysis syndrome in lymphoid malignancies. (12672271)
2003
41
Hyperuricemia causes glomerular hypertrophy in the rat. (12373074)
2003
42
Pathogenesis of hyperuricemia: recent advances. (12010614)
2002
43
Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricemia and gout. (11821722)
2002
44
Hyperuricemia and gout: a reign of complacency. (12184467)
2002
45
Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy. (12014742)
2002
46
Hyperuricemia in Saudi Arabia. (11269534)
2001
47
Hyperuricemia, oxidative stress in preeclampsia. (11354030)
2001
48
The treatment of hyperuricemia: allopurinol and beyond. (19078354)
1999
49
Controlling hyperuricemia. (9858456)
1998
50
Leukemoid reaction, hyperuricemia and severe hyperpyrexia complicating a fatal case of acute fatty liver of the alcoholic. (13880646)
1962

Genetic Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyperuricemia

Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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Sources:
49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Hyperuricemia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hyperuricemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1potassium44 11 2412.7ADRB3, GCK, PIK3C2A
26 mercaptopurine4410.7XDH, HPRT1, GPT
3glucose4410.7GCK, HNF1B, UMOD, PIK3C2A, PFKM
4niacin44 1111.7GPT, INS, HPRT1, APOB
5nash4410.7GPT, GGT1, INS
6gemfibrozil44 28 1112.6APOB, PIK3C2A, INS, GPT
7carnitine4410.6INS, SLC22A12, APOB, PFKM
8allopurinol44 49 1112.6HPRT1, UMOD, XDH
9mannitol44 1111.6GGT1, G6PC, GCK
102,8-dihydroxyadenine4410.6HPRT1, XDH
11malondialdehyde4410.6PIK3C2A, XDH, GPT, GGT1, G6PC
12fenofibrate44 49 1112.6INS, GPT, FABP2, APOB, PIK3C2A
131-nitropyrene4410.6GGT1, HPRT1
14azathioprine44 49 2 1113.6GPT, HPRT1, XDH, GGT1
15pioglitazone44 49 28 1113.6INS, GPT, GGT1, APOB
16metformin44 49 1112.6APOB, INS, GPT, GGT1, GCK
17ezetimibe44 1111.6INS, APOB, GPT
18bezafibrate44 28 1112.6PIK3C2A, APOB, INS, GPT, GGT1
196-thiouric acid4410.6XDH, HPRT1
20h2o24410.6GCK, G6PC, HPRT1
21vitamin a44 11 2412.6HPRT1, GGT1, FABP2, APOB, GPT
22haloperidol44 28 2 49 1114.6PIK3C2A, APOB, GPT, GGT1
23isoflurane44 1111.6GGT1, GPT, PIK3C2A
24pyruvate4410.6G6PC, GCK, GPT, PIK3C2A, PFKM, FABP2
25thyroxine44 2411.6GGT1, INS, APOB, GPT, PIK3C2A
26urea44 11 2412.6ADRB3, GGT1, FABP2, UMOD, GPT, G6PC
27lovastatin44 49 59 28 1114.6GGT1, PIK3C2A, APOB, GPT
28glutamine4410.5GGT1, HPRT1, G6PC, APOB, GCK, GPT
29pyrophosphate44 2411.5G6PC, SARS2, SARS, PIK3C2A, HPRT1
30adenylate4410.5GPT, APOB, HPRT1, G6PC, ADRB3, GCK
31glycogen44 2411.5GCK, FABP2, G6PC, PIK3C2A, PFKM, INS
32dexamethasone44 49 28 1113.5INS, GGT1, HPRT1, G6PC, APOB, GCK
33fatty acid4410.5ADRB3, PFKM, PIK3C2A, G6PC, FABP2, GCK
34magnesium44 11 2412.5PIK3C2A, PRPS1L1, GPT, PFKM, GCK, UMOD
35rosuvastatin44 49 28 1113.5INS, APOB, GPT
36adenine44 11 2412.4HPRT1, XDH, GGT1, APOB
37chromium picolinate4410.4INS, GCK
38glutamate4410.4GGT1, PIK3C2A, GPT, INS, HPRT1, G6PC
39lactate4410.4GGT1, GPT, INS, PFKM, XDH, PIK3C2A
40arginine4410.4INS, GPT, GGT1, ADRB3, PIK3C2A, XDH
41cholesterol44 28 11 2413.4GGT1, G6PC, GCK, HNF1B, APOB, ADRB3
42alanine4410.4GPT, GGT1, G6PC, ADRB3, GCK, APOB
43creatinine4410.4GCK, APOB, GGT1, SLC22A12, GPT, INS
44policosanol4410.4PIK3C2A, GPT
45choline44 11 2412.3GPT, PIK3C2A, GGT1, APOB
46uric acid44 2411.3SLC22A12, ADRB3, GGT1, GPT, INS, XDH
47lipid4410.3G6PC, PIK3C2A, XDH, PFKM, GGT1, GPT
48silymarin4410.3XDH, GGT1, GPT
49aicar44 11 2412.2G6PC, GCK, INS
50phosphorus4410.0PIK3C2A, GGT1, GPT

GO Terms for genes affiliated with Hyperuricemia

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16Gene Ontology
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Cellular components related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:03190410.4INS, APOB

Biological processes related to Hyperuricemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1seryl-tRNA aminoacylationGO:00643410.6SARS, SARS2
2selenocysteinyl-tRNA(Sec) biosynthetic processGO:09705610.5SARS, SARS2
3glucose homeostasisGO:04259310.5GCK, G6PC, PFKM, INS
4endocrine pancreas developmentGO:03101810.5GCK, HNF1B, INS
5glucose transportGO:01575810.4GCK, G6PC, INS
6negative regulation of gluconeogenesisGO:04572110.4INS, GCK
7urate metabolic processGO:04641510.4G6PC, SLC22A12
8carbohydrate metabolic processGO:00597510.3ADRB3, PFKM, G6PC, GCK
9positive regulation of glycolysisGO:04582110.3GCK, INS
10small molecule metabolic processGO:04428110.2GGT1, GCK, APOB, G6PC, PIK3C2A, XDH
11positive regulation of glycogen biosynthetic processGO:04572510.1INS, GCK

Molecular functions related to Hyperuricemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.2ADRB3, HPRT1, XDH, PRPS1L1, HNF1B
2serine-tRNA ligase activityGO:00482810.1SARS, SARS2

Products for genes affiliated with Hyperuricemia

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Hyperuricemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet