MCID: HYP014
MIFTS: 47

Hyperuricemia malady

Blood diseases, Rare diseases categories

Summaries for Hyperuricemia

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Disease Ontology:9 An acquired metabolic disease that has material basis in an abnormally high level of uric acid in the blood.

MalaCards based summary: Hyperuricemia, also known as blood urate raized, is related to gout and lesch-nyhan syndrome. An important gene associated with Hyperuricemia is UMOD (uromodulin), and among its related pathways are Uric Acid-Lowering Drugs Pathway, Pharmacodynamics and Purine metabolism. The drugs mannitol hexanitrate and rasburicase and the compounds benzbromarone and pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are adipose tissue and renal/urinary system.

Wikipedia:63 Hyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid,... more...

Aliases & Classifications for Hyperuricemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Hyperuricemia, Aliases & Descriptions:

Name: Hyperuricemia 9 11 43 60
Blood Urate Raized 9
 
Uricacidemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:1920
NCIt38 C3961
MeSH33 D033461

Related Diseases for Hyperuricemia

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Diseases in the Hyperuricemia family:

Hereditary Hyperuricemia

Diseases related to Hyperuricemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.8HPRT1, UMOD
2lesch-nyhan syndrome31.0XDH, HPRT1
3nephrolithiasis30.5XDH, UMOD
4hyperuricemic nephropathy, familial juvenile 130.5HPRT1, UMOD
5fatty liver disease30.2FABP2, ADRB3
6glycogen storage disease29.8G6PC, PFKM
7atherosclerosis29.8FABP2, ADRB3, XDH
8hypertriglyceridemia29.7G6PC, FABP2, ADRB3
9coronary artery disease29.7FABP2, XDH, ADRB3
10kidney disease10.6
11obesity10.5
12endotheliitis10.4
13hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.4
14hypouricemia, renal10.3SLC22A12, HPRT1
15cystinuria10.3
16glomerulocystic kidney disease with hyperuricemia and isosthenuria10.3
17arthritis10.2
18nephronophthisis10.2
19deafness hyperuricemia neurologic ataxia10.2
20hereditary hyperuricemia10.2
21blindness10.2
22acute urate nephropathy10.2XDH, HPRT1
23glycogen storage disease ia10.2
24liver disease10.2
25nephropathy familial with hyperuricemia10.2
26developmental disabilities10.2G6PC, HPRT1
27lipodystrophy, familial partial, type 310.1
28paget disease, juvenile10.1
29glycogen storage disease vii10.1
30phosphoribosylpyrophosphate synthetase superactivity10.1
31myocardial infarction10.1
32psoriatic arthritis10.1
33fructose intolerance10.1
34acute myocardial infarction10.1
35hepatitis10.1
36leukemia10.1
37athetosis10.1
38hyperuricemia - anemia - renal failure10.1
39autosomal dominant medullary cystic kidney disease with hyperuricemia10.1
40morbid obesity10.1ADRB3, FABP2
41hyperlipidemia, familial combined10.1ADRB3, FABP2
42medullary cystic kidney disease 210.0
43renal cysts and diabetes syndrome10.0
44hyperuricemic nephropathy, familial juvenile 210.0
45pulmonary hypertension10.0
46ischemic heart disease10.0
47hepatitis c10.0
48hemolytic-uremic syndrome10.0
49atrial fibrillation10.0
50polycythemia10.0

Graphical network of the top 20 diseases related to Hyperuricemia:



Diseases related to hyperuricemia

Symptoms for Hyperuricemia

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Drugs & Therapeutics for Hyperuricemia

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Drug clinical trials:

Search ClinicalTrials for Hyperuricemia

Search NIH Clinical Center for Hyperuricemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hyperuricemia

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Anatomical Context for Hyperuricemia

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MalaCards organs/tissues related to Hyperuricemia:

31
Kidney, Heart, Endothelial, Liver, Bone marrow, Bone, Cortex, Thyroid, Breast, Testes, Myeloid, Neutrophil

Animal Models for Hyperuricemia or affiliated genes

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MGI Mouse Phenotypes related to Hyperuricemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2ADRB3, FABP2, UMOD, XDH
2MP:00053678.0UMOD, SLC22A12, XDH, G6PC, FABP2, HPRT1
3MP:00053867.8SLC22A12, G6PC, PFKM, ADRB3, HPRT1
4MP:00053797.7PFKM, HPRT1, SLC22A12, XDH, ADRB3
5MP:00053787.3ADRB3, SLC22A12, UMOD, HPRT1, FABP2, XDH
6MP:00053766.6PFKM, SLC22A12, UMOD, HPRT1, FABP2, ADRB3

Publications for Hyperuricemia

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Articles related to Hyperuricemia:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Effects of febuxostat on serum urate level in Japanese hyperuricemia patients. (25671406)
2015
2
Assessment of a possible link between hyperhomocysteinemia and hyperuricemia. (25646870)
2015
3
Compound Tufuling Granules () regulate glucose transporter 9 expression in kidney to influence serum uric acid level in hyperuricemia mice. (25864117)
2015
4
Effects of hyperuricemia on renal function in pediatric renal transplant recipients. (25894164)
2015
5
Hyperuricemia is independently associated with increased risk of atrial fibrillation: A meta-analysis of cohort studies. (25777070)
2015
6
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
7
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
8
Definition of hyperuricemia and gouty conditions. (24419750)
2014
9
The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population. (25705163)
2014
10
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
11
Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. (23942050)
2013
12
Hyperuricemia is associated with hypertension, obesity, and albuminuria in children with chronic kidney disease. (22809658)
2013
13
The association between hyperuricemia and betel nut chewing in Taiwanese men: a cross-sectional study. (24308550)
2013
14
Mediterranean diet and risk of hyperuricemia in elderly participants at high cardiovascular risk. (23599357)
2013
15
Variation of urate transport in the nephrons in subtypes of hyperuricemia. (24052801)
2013
16
Splenectomy is a risk factor for developing hyperuricemia and nephrolithiasis in patients with thalassemia intermedia: a retrospective study. (22705193)
2012
17
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
18
Rasburicase in cancer-related hyperuricemia. (21850282)
2011
19
The prevalence of hyperuricemia in China: a meta-analysis. (22032610)
2011
20
Japanese guideline for the management of hyperuricemia and gout: second edition. (22132951)
2011
21
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (21654265)
2011
22
Lack of association between dietary fructose and hyperuricemia risk in adults. (20193069)
2010
23
Gout and hyperuricemia. (21229813)
2010
24
Association of urinary albumin excretion rate and hyperuricemia with macrovascular atherosclerosis in type 2 diabetic patients]. (20118005)
2010
25
A study of rasburicase for the management of hyperuricemia in pediatric patients with newly diagnosed hematologic malignancies at high risk for tumor lysis syndrome. (19701676)
2009
26
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
27
Efficacy and safety of losartan in treatment of hyperuricemia and posttransplantation erythrocytosis: results of a prospective, open, randomized, case-control study. (19917377)
2009
28
Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome. (18992978)
2009
29
Hyperuricemia is associated with the development of the composite outcomes of new cardiovascular events and chronic allograft nephropathy. (18791445)
2008
30
The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. (17225053)
2007
31
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. (17190912)
2007
32
Drug discovery for hyperuricemia. (23496132)
2007
33
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (16385546)
2006
34
Is hyperuricemia a cardiovascular risk factor?]. (17017483)
2006
35
Is hyperuricemia another facet of the metabolic syndrome? (16599014)
2006
36
Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. (16448895)
2006
37
Frequency of hyperuricemia and effect of calcineurin inhibitors on serum uric acid levels in liver transplanted children. (16911488)
2006
38
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
39
Hyperuricemia and bone marrow transplantation. (15604610)
2005
40
The effect of alcoholic beverage type on hyperuricemia in Japanese male office workers. (15762093)
2005
41
Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. (15824465)
2004
42
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
43
Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. (15170929)
2004
44
Diuretic-induced hyperuricemia does not decrease cardiovascular risk. (15201561)
2004
45
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
46
Pathogenesis of hyperuricemia: recent advances. (12010614)
2002
47
Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. (11398134)
2001
48
Latent overproductive hyperuricemia increases in patients during the intermittent phase of gouty arthritis under long-term antihyperuricemic treatment. (24383630)
2000
49
Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. (10413068)
1999
50
Safety of losartan in hypertensive patients with thiazide-induced hyperuricemia. (10571797)
1999

Variations for Hyperuricemia

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Expression for genes affiliated with Hyperuricemia

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Search GEO for disease gene expression data for Hyperuricemia.

Pathways for genes affiliated with Hyperuricemia

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Pathways related to Hyperuricemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC22A12, XDH
2
Show member pathways
purine deoxyribonucleosides degradation36
purine nucleotides degradation36
adenine and adenosine salvage II36
adenine and adenosine salvage III36
oxidized GTP and dGTP detoxification36
urate biosynthesis/inosine 5-phosphate degradation36
adenine and adenosine salvage I36
purine ribonucleosides degradation to ribose-1-phosphate36
inosine-5-phosphate biosynthesis36
guanosine nucleotides degradation36
guanine and guanosine salvage36
adenosine nucleotides degradation36
5-aminoimidazole ribonucleotide biosynthesis36
9.5HPRT1, XDH
3
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.2PFKM, G6PC
4
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I36
galactose degradation I (Leloir pathway)36
Cori Cycle36
9.2G6PC, PFKM
5
Show member pathways
9.1HPRT1, G6PC, XDH

Compounds for genes affiliated with Hyperuricemia

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Compounds related to Hyperuricemia according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1benzbromarone4310.0SLC22A12, XDH
2pyrazinamide43 49 1212.0XDH, SLC22A12
36-thiouric acid4310.0HPRT1, XDH
42,8-dihydroxyadenine4310.0HPRT1, XDH
5tiazofurin439.9XDH, HPRT1
6mercaptopurine49 1210.9HPRT1, XDH
7didanosine43 49 1211.9HPRT1, XDH
8thiopurine439.9HPRT1, XDH
96 mercaptopurine439.9HPRT1, XDH
10probenecid28 43 59 49 1213.9XDH, SLC22A12
11purine nucleoside439.9XDH, HPRT1
12inosine43 2410.8XDH, HPRT1
13hypoxanthine43 24 1211.8HPRT1, XDH
14acetaldehyde28 43 2411.8HPRT1, XDH
15xanthine43 2410.7HPRT1, XDH
16succinate439.7HPRT1, G6PC
17peroxynitrite439.7UMOD, XDH
18galactose439.7UMOD, G6PC
19malondialdehyde439.6XDH, G6PC
20carvedilol43 49 28 1212.6ADRB3, XDH
21allopurinol43 49 1211.6XDH, HPRT1, UMOD
22losartan43 49 28 1212.6SLC22A12, XDH
23pyrophosphate43 2410.5HPRT1, SARS2, G6PC
24dmso439.5HPRT1, G6PC, XDH
25nadph43 2410.2XDH, G6PC, FABP2
26pyruvate439.0G6PC, PFKM, FABP2
27carnitine439.0SLC22A12, PFKM
28cysteine439.0UMOD, HPRT1, FABP2, XDH
29urea43 24 1211.0G6PC, ADRB3, FABP2, UMOD
30adenylate438.9G6PC, ADRB3, HPRT1
31lactate438.9PFKM, G6PC, XDH
32magnesium43 24 1210.8G6PC, PFKM, HPRT1, UMOD
33arginine438.8XDH, G6PC, ADRB3, HPRT1
34creatinine438.5SLC22A12, UMOD, HPRT1, FABP2, PFKM
35glycogen43 249.5G6PC, PFKM, ADRB3, FABP2
36fatty acid438.4FABP2, ADRB3, PFKM, G6PC
37alanine438.4FABP2, ADRB3, PFKM, G6PC
38uric acid43 249.2SLC22A12, UMOD, HPRT1, ADRB3, G6PC, XDH
39glucose438.1G6PC, PFKM, ADRB3, FABP2, UMOD
40lipid437.9XDH, G6PC, PFKM, ADRB3, FABP2

GO Terms for genes affiliated with Hyperuricemia

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Cellular components related to Hyperuricemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.0SLC22A12, UMOD, PFKM

Biological processes related to Hyperuricemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1urate metabolic processGO:00464159.8SLC22A12, G6PC
2purine nucleobase metabolic processGO:00061449.6HPRT1, XDH
3nucleobase-containing small molecule metabolic processGO:00550869.4XDH, HPRT1
4glucose homeostasisGO:00425939.2PFKM, G6PC
5carbohydrate metabolic processGO:00059758.6ADRB3, PFKM, G6PC
6small molecule metabolic processGO:00442818.0HPRT1, PFKM, G6PC, XDH

Products for genes affiliated with Hyperuricemia

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Sources for Hyperuricemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet