Hyperuricemic Nephropathy malady

MalaCards: Hyperuricemic Nephropathy, also known as nephropathy, hyperuricemic, is related to familial juvenile hyperuricemic nephropathy and umod-associated kidney disease. An important gene associated with Hyperuricemic Nephropathy is UMOD (uromodulin), and among its related pathways are Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics and Maturity onset diabetes of the young. The compounds moxonidine and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

hyperuricemic nephropathy 7 nephropathy, hyperuricemic 43

Diseases related to hyperuricemic nephropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 61)

id	Related Disease	Score	Top Affiliating Genes
1	familial juvenile hyperuricemic nephropathy	34.9	HPRT1, HNF1B, UMOD
2	umod-associated kidney disease	32.4	MCKD2, UMOD
3	familial juvenile hyperuricaemic nephropathy	31.6	UMOD, MCKD2
4	nephropathy	31.4	HNFJ3, NPHP1, HPRT1, REN, UMOD, INS
5	gout	30.1	HPRT1, UMOD
6	cystic kidney	30.1	HNF1B, UMOD
7	glomerulocystic kidney disease	29.8	MCKD2, UMOD, HNF1B
8	glomerulocystic kidney disease with hyperuricemia and isosthenuria	13.3	MCKD2, UMOD
9	bartter disease	13.3	UMOD, REN
10	horseshoe kidney	13.2	REN, HNF1B
11	hyporeninemic hypoaldosteronism	13.1	REN, INS
12	hypoaldosteronism	13.1	REN, INS
13	renal hypouricemia	13.1	HPRT1, SLC22A12
14	postural hypotension	13.0	REN, INS
15	vesicoureteral reflux	13.0	REN, HNF1B, UMOD
16	orofaciodigital syndrome	13.0	KIF3A, OFD1
17	chronic kidney failure	13.0	REN, INS
18	fragile x-associated primary ovarian insufficiency	12.9	REN, INS
19	polycystic kidney disease	12.9	HNF1B, UMOD
20	neonatal diabetes mellitus	12.9	INS, HNF1B
21	diabetic macular edema	12.9	INS, REN
22	hypomagnesemia	12.8	INS, HNF1B, REN
23	renovascular hypertension	12.8	REN, INS
24	thyroid hormone metabolism	12.8	INS, CRYM
25	developmental disabilities	12.8	HPRT1, HNF1B, OFD1
26	turner syndrome	12.7	REN, HNF1B, INS
27	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	12.6	OFD1, NPHP1
28	oculomotor apraxia	12.6	OFD1, NPHP1
29	high blood pressure	12.6	REN, INS
30	hypouricemia	12.6	HPRT1, SLC22A12, INS
31	nephronophthisis 4	12.5	NPHP1, NPHP4
32	nephronophthisis 1	12.4	NPHP4, NPHP1
33	uremia	12.4	REN, INS, NPHP1
34	cystinosis	12.4	REN, INS
35	hyperthyroidism	12.3	CRYM, INS, REN
36	nephrolithiasis	12.3	SLC22A12, HPRT1, INS, UMOD
37	end stage renal failure	12.3	NPHP4, INS, UMOD
38	nephronopthisis	12.2	NPHP4, UMOD, NPHP1
39	polydactyly	12.2	INS, NPHP1, OFD1
40	nephronophthisis	12.2	NPHP4, NPHP1, UMOD
41	twinning	12.2	UMOD, INS, REN, HNF1B, HPRT1
42	cerebellar ataxia	12.2	NPHP1, INS, OFD1
43	primary hyperoxaluria	12.2	INS, NPHP1, SLC22A12
44	focal segmental glomerulosclerosis	12.1	INS, NPHP4, REN
45	bardet-biedl syndrome	12.1	KIF3A, INS, NPHP4
46	senior-loken syndrome	12.1	NPHP1, NPHP4
47	was-related disorders	12.1	KIF3A, REN, INS, NPHP1
48	situs inversus	12.0	NPHP4, NPHP1, KIF3A
49	asphyxiating thoracic dystrophy	12.0	NPHP4, NPHP1, OFD1
50	joubert syndrome	12.0	NPHP1, OFD1, NPHP4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hyperuricemic nephropathy:

²²

MGI Mouse Phenotypes related to hyperuricemic nephropathy:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	7.5	SLC22A12, REN, INS, HPRT1, NPHP4, NPHP1
2	endocrine/exocrine gland phenotype	MP:0005379	7.5	HPRT1, HNF1B, CRYM, SLC22A12, INS, NPHP1
3	homeostasis/metabolism phenotype	MP:0005376	7.2	HNF1B, REN, KIF3A, UMOD, INS, SLC22A12
4	growth/size phenotype	MP:0005378	7.0	KIF3A, UMOD, REN, SLC22A12, CRYM, OFD1
5	cardiovascular system phenotype	MP:0005385	7.0	CRYM, HPRT1, KIF3A, REN, OFD1, NPHP4
6	renal/urinary system phenotype	MP:0005367	6.5	NPHP4, SLC22A12, REN, KIF3A, INS, UMOD

Articles related to hyperuricemic nephropathy:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Familial juvenile hyperuricemic nephropathy: report on a new mutation and a pregnancy. (19203555)	Lhotta K.... Strazdins V.	2009	UMOD
2	Familial juvenile hyperuricemic nephropathy (FJHN) (18409515)	Kudo E.... Itakura M.	2008	UMOD
3	Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy. (17151335)	Jennings P.... Pfaller W.	2007	UMOD
4	A novel pattern of mutation in uromodulin disorders: autosomal dominant medullary cystic kidney disease type 2, familial juvenile hyperuricemic nephropathy, and autosomal dominant glomerulocystic kidney disease. (15983957)	Lens X.M.... Barrio-Lucia V.	2005	UMOD
5	A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy. (15673476)	Calado J.... Rueff J.	2005	UMOD
6	Familial juvenile hyperuricemic nephropathy: detection of mutations in the uromodulin gene in five Japanese families. (15086896)	Kudo E.... Itakura M.	2004	UMOD, HNF1B
7	A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. (14569098)	Dahan K.... Pirson Y.	2003	UMOD
8	Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation. (12675839)	Bingham C.... Hattersley A.T.	2003	HNF1B
9	UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy. (12629136)	Turner J.J.O.... Thakker R.V.	2003	UMOD
10	Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family. (10765940)	Kamatani N.... Itakura M.	2000	UMOD
11	Hyperuricemic nephropathies. (9873214)	Steele T.H.	1999	INS

Genes related to hyperuricemic nephropathy according to GeneCards:

(show all 13)

id	Symbol	Description	Score	GeneCards Section Context
1	UMOD	uromodulin	11.1	Summaries, Publications
2	HNFJ3	Hyperuricemic nephropathy, familial juvenile, 3	11.1	Aliases & Descriptions
3	REN	renin	11.0
4	HNF1B	HNF1 homeobox B	11.0	Publications
5	MCKD2	medullary cystic kidney disease 2 (autosomal dominant)	11.0
6	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0
7	KIF3A	kinesin family member 3A	11.0
8	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.0	Disorders
9	OFD1	oral-facial-digital syndrome 1	11.0
10	CRYM	crystallin, mu	11.0
11	NPHP4	nephronophthisis 4	11.0
12	NPHP1	nephronophthisis 1 (juvenile)	11.0
13	INS	insulin	11.0	Publications

Pathways related to hyperuricemic nephropathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	9.7	INS, HNF1B
2	Maturity onset diabetes of the young20	9.4	INS, HNF1B
3	Selected targets of HNF110	9.3	UMOD, INS, HNF1B

Compounds related to hyperuricemic nephropathy according to GeneDecks:

(show all 11)

id	Compound	Score	Top Affiliating Genes
1	moxonidine32	9.8	INS, REN
2	olmesartan32 9 9	11.8	INS, REN
3	ramipril32 9 9	11.8	INS, REN
4	thiazide32	9.7	REN, INS
5	cyproteroneacetate32	9.7	INS, REN
6	allopurinol32 9 9	11.6	UMOD, HPRT1
7	telmisartan32 9 9	11.6	REN, INS
8	nicotinamide32 9 9	11.5	INS, HPRT1, HNF1B
9	thyroxine32 18	10.2	REN, CRYM, INS
10	uric acid32 18	9.9	HNF1B, SLC22A12, UMOD, INS, HPRT1
11	creatinine32	8.9	REN, SLC22A12, HPRT1, INS, UMOD

Cellular components related to hyperuricemic nephropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	primary cilium	GO:072372	9.8	KIF3A, UMOD

Biological processes related to hyperuricemic nephropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	visual behavior	GO:007632	9.0	NPHP1, NPHP4

Molecular functions related to hyperuricemic nephropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor receptor binding	GO:005159	9.7	REN, INS