MCID: HYP058
MIFTS: 46

Hypervitaminosis a malady

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Summaries for Hypervitaminosis a

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hypervitaminosis A refers to any number of a large amount of toxic effects from ingesting too much... more...

MalaCards: Hypervitaminosis a is related to protein-energy malnutrition and papilloma. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are the visual cycle I (vertebrates) and Visual Cycle in Retinal Rods. The compounds n-(4-hydroxyphenyl)retinamide and purpurin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotypes are muscle and no phenotypic analysis.

Aliases & Classifications for Hypervitaminosis a

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8Disease Ontology, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

hypervitaminosis a 8 45 62


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Disease Ontology8 DOID:9972
ICD9CM27 278.2
SNOMED-CT58 64559002
MeSH35 D006986
ICD1025 E67.0

Related Diseases for Hypervitaminosis a

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Symptoms for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Hypervitaminosis a

Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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33MalaCards
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MalaCards organs/tissues related to Hypervitaminosis a:

33
Bone, Liver, Lung, Skin, Thyroid, Testes, Adrenal gland, Breast, Pancreas, Salivary gland, Smooth muscle, Heart, Bone marrow, Eye, Kidney, Tongue, Brain, Pituitary

Animal Models for Hypervitaminosis a or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypervitaminosis a:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CDKN1B, CDKN1A, RBP4
2MP:00030128.2CDKN1B, CDKN1A, TTR
3MP:00053918.0CDKN1B, CDKN1A, RBP4, TTR
4MP:00053767.9TTR, RBP4, CDKN1A, CDKN1B

Publications for Hypervitaminosis a

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52PubMed
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Articles related to Hypervitaminosis a:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
2
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
3
Acute hypervitaminosis A in a young lady. (20395929)
2010
4
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. (16289060)
2006
5
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. (11716591)
2000
6
Assessment of risk factors for carotenodermia and cutaneous signs of hypervitaminosis A in college-aged populations. (1764358)
1991
7
Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats. (3147800)
1988
8
Hepatic and dermatologic manifestations of chronic hypervitaminosis A in adults. Report of two cases. (2937294)
1986
9
Hypervitaminosis A in a child from megadosing. (3988928)
1985
10
Ingestion of shark liver associated with pseudotumor cerebri due to acute hypervitaminosis A. (6707663)
1984
11
Discordant hepatic uptake between Tc-99m sulfur colloid and Tc-99m DISIDA in hypervitaminosis A. (6539369)
1984
12
Clinical manifestations of hypervitaminosis A in human gingiva. A case report. (6592319)
1984
13
Oxygen consumption and survival prediction in neonatal rats exposed to prenatal hypervitaminosis A. (6417812)
1983
14
Protein-calorie deficiency and vitamin indiscretion in an atopic child who developed hypervitaminosis A. (6799241)
1982
15
Morphometric study of malformations induced by hypervitaminosis A on rat fetus Meckel cartilage, maxillary bone and mandible. (6762114)
1982
16
Malformations of the eye resulting from maternal hypervitaminosis A during gestation in the rat. (6800208)
1981
17
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
18
Morphometric study of the reversibility of testicle alterations in rats submitted to hypervitaminosis A. (738845)
1978
19
Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. (20486)
1977
20
Morphologic alterations associated with decreased cerebrospinal fluid pressure in chronic bovine hypervitaminosis A. (1111381)
1975
21
Ultrastructural changes in livers of two patients with hypervitaminosis A. (4416771)
1974
22
Effect of hypervitaminosis A on immunocompetence in rats. (4549758)
1974
23
A light and electron microscopic study of the lymphomyeloid complex in hypervitaminosis A. (5075296)
1972
24
Lack of hypertrophy of the adrenal in exencephalic fetal rats subjected to hypervitaminosis A and then to maternal adrenalectomy. (4324682)
1971
25
Hypervitaminosis A dysmelia in rats. (4332598)
1971
26
Rates of formation and absorption of cerebrospinal fluid in mild chronic bovine hypervitaminosis A. (5479487)
1970
27
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
28
Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity. (5485475)
1970
29
Hepatic injury in chronic hypervitaminosis A. (5410560)
1970
30
Effects of ovariectomy and hypervitaminosis A on lysosomes of the rat conceptus. (4312014)
1969
31
Effect of hypervitaminosis A on intestinal lipids of rats. (6048389)
1967
32
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
33
Bone strength and calcium retention of rats in hypervitaminosis-A. (5178796)
1966
34
MALFORMATIONS OF THE MOUSE FETUS CAUSED BY HYPERVITAMINOSIS-A OF THE MOTHER DURING PREGNANCY. (14280198)
1965
35
ALTERATIONS IN THE LIPIDS OF BONE CAUSED BY HYPERVITAMINOSIS A AND D. (14343141)
1965
36
Carbohydrate metabolism in hypervitaminosis A. (14436609)
1959
37
Analysis of an anomalous oculodentofacial pattern in newborn rats produced by maternal hypervitaminosis A. (13631147)
1959
38
Late effects of hypervitaminosis A in the rat; disturbance and retardation in the normal growth of offspring. (13570808)
1958
39
Hypervitaminosis A; toxic reaction. (13508636)
1958
40
Hypervitaminosis A. (13425777)
1957
41
Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats. (13328832)
1956
42
Chronic hypervitaminosis A; report of a probable case in a man. (13265422)
1955
43
The biochemistry and pathology of hypervitaminosis A. (14374254)
1954
44
The activity of ascorbic acid in hypervitaminosis-A in the guinea-pig. (13128868)
1953
45
Hypervitaminosis; a study of an unusual case. (14934528)
1952
46
Hypervitaminosis A; a case report. (14890815)
1952
47
Effect of hypervitaminosis A on hepatic ascorbic acid in the rat. (14924655)
1952
48
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951
49
Hypervitaminosis A; report of a case. (14774092)
1950
50
Hypervitaminosis A; a case report. (18872296)
1948

Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 51PharmGKB, 60Thomson Reuters, 12EMD Millipore, 5Cell Signaling Technology, 54R&D Systems
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Pathways related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TTR, RBP4
29.3TTR, RBP4
3
Show member pathways
9.3TTR, RBP4
4
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1CDKN1B, CDKN1A
5
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1CDKN1A, CDKN1B
6
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.1CDKN1A, CDKN1B
79.1CDKN1B, CDKN1A
8
Show member pathways
Cell cycle38
9.1CDKN1B, CDKN1A
9
Show member pathways
9.1CDKN1A, CDKN1B
109.1CDKN1B, CDKN1A
11
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.1CDKN1A, CDKN1B
129.1CDKN1A, CDKN1B
139.1CDKN1B, CDKN1A
14
Show member pathways
9.1CDKN1B, CDKN1A
159.1CDKN1B, CDKN1A
16
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CDKN1B, CDKN1A
179.1CDKN1B, CDKN1A
18
Show member pathways
9.1CDKN1B, CDKN1A
199.1CDKN1A, CDKN1B
20
Show member pathways
9.1CDKN1B, CDKN1A
219.1CDKN1B, CDKN1A
229.1CDKN1B, CDKN1A
239.1CDKN1B, CDKN1A
249.1CDKN1A, CDKN1B
25
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1CDKN1B, CDKN1A
26
Show member pathways
AhR pathway38
9.1CDKN1B, CDKN1A
279.1CDKN1A, CDKN1B
28
Show member pathways
DNA damage response38
9.1CDKN1B, CDKN1A
29
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1CDKN1A, CDKN1B
309.1CDKN1B, CDKN1A
31
Show member pathways
9.1CDKN1A, CDKN1B
32
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.1CDKN1B, CDKN1A
339.1CDKN1B, CDKN1A
349.1CDKN1B, CDKN1A
359.1CDKN1A, CDKN1B
36
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.6CDKN1B, CDKN1A, RBP4
378.0TTR, RBP4, CDKN1A, CDKN1B
38
Show member pathways
8.0CDKN1B, CDKN1A, RBP4, TTR

Compounds for genes affiliated with Hypervitaminosis a

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1n-(4-hydroxyphenyl)retinamide459.8CDKN1A, RBP4
2purpurin459.8RBP4, TTR
3retinyl palmitate45 2410.8RBP4, TTR
4lutein459.8RBP4, TTR
5tocopherol459.8RBP4, TTR
6cellulose acetate459.7RBP4, TTR
7phosphorus459.7TTR, RBP4
8isoleucine459.7RBP4, TTR
9betacarotene459.7RBP4, TTR
10triiodothyronine459.7RBP4, TTR
11uric acid45 2410.6RBP4, TTR
12vitamin-e459.6RBP4, TTR
13mimosine45 1110.6CDKN1A, CDKN1B
14eb 108945 6110.5CDKN1A, CDKN1B
15phorbol459.5CDKN1A, RBP4
16aphidicolin459.5CDKN1B, CDKN1A
17ciglitazone45 2910.5CDKN1B, CDKN1A
18alpha tocopherol459.5RBP4, TTR
19ns 39845 6110.5CDKN1B, CDKN1A
20indole-3-carbinol459.5CDKN1B, CDKN1A
21leptomycin b45 6110.5CDKN1A, CDKN1B
22flavopiridol45 1110.5CDKN1B, CDKN1A
23celecoxib45 61 29 51 24 1114.5CDKN1B, CDKN1A
24bortezomib45 51 1111.5CDKN1B, CDKN1A
25gefitinib45 51 1111.4CDKN1A, CDKN1B
26gemcitabine45 51 1111.4CDKN1B, CDKN1A
27lactacystin459.4CDKN1B, CDKN1A
28lovastatin45 51 61 29 1113.4CDKN1A, CDKN1B
29urea45 24 1111.3RBP4, TTR
30rosiglitazone29 45 51 24 1113.3CDKN1A, RBP4
31ornithine45 2410.3CDKN1B, RBP4
32retinoid459.3CDKN1A, RBP4, TTR
33cytarabine45 51 1111.2CDKN1B, CDKN1A
34progesterone45 29 61 24 1113.0CDKN1B, CDKN1A, RBP4
35resveratrol45 61 24 1112.0CDKN1B, CDKN1A, TTR
36agar459.0TTR, CDKN1A, CDKN1B
37paraffin458.9TTR, CDKN1A, CDKN1B
38genistein45 29 61 3 24 1113.9CDKN1B, CDKN1A, TTR
39leucine458.9TTR, RBP4, CDKN1B
40testosterone45 61 24 1111.9CDKN1B, RBP4, TTR
41cholesterol45 29 24 1111.9TTR, RBP4, CDKN1B
42dexamethasone45 51 29 1111.9TTR, RBP4, CDKN1B
43troglitazone45 29 61 1111.8CDKN1B, CDKN1A
44threonine458.8CDKN1B, CDKN1A, TTR
45alanine458.8TTR, RBP4, CDKN1B
46oxygen45 249.8RBP4, CDKN1A, CDKN1B
47glucose458.5TTR, RBP4, CDKN1B
48estrogen458.4TTR, RBP4, CDKN1A, CDKN1B
49retinoic acid45 249.4CDKN1B, CDKN1A, RBP4, TTR
50serine458.4CDKN1B, CDKN1A, RBP4, TTR

GO Terms for genes affiliated with Hypervitaminosis a

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16Gene Ontology
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Cellular components related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5CDKN1B, RBP4, TTR

Biological processes related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.6RBP4, TTR
2retinoid metabolic processGO:0015239.6RBP4, TTR
3phototransduction, visible lightGO:0076039.5TTR, RBP4
4mitotic cell cycle arrestGO:0718509.4CDKN1B, CDKN1A
5negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.4CDKN1B, CDKN1A
6negative regulation of phosphorylationGO:0423269.4CDKN1A, CDKN1B
7regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CDKN1B, CDKN1A
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.3CDKN1B, CDKN1A
9negative regulation of cell growthGO:0303089.3CDKN1B, CDKN1A
10cell cycle arrestGO:0070509.2CDKN1B, CDKN1A
11phosphatidylinositol-mediated signalingGO:0480159.2CDKN1B, CDKN1A
12G1/S transition of mitotic cell cycleGO:0000829.1CDKN1A, CDKN1B
13epidermal growth factor receptor signaling pathwayGO:0071739.1CDKN1B, CDKN1A
14fibroblast growth factor receptor signaling pathwayGO:0085439.0CDKN1B, CDKN1A
15Fc-epsilon receptor signaling pathwayGO:0380958.8CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1CDKN1B, CDKN1A
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048618.8CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

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Sources for Hypervitaminosis a

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet