MCID: HYP058
MIFTS: 46

Hypervitaminosis a malady

Summaries for Hypervitaminosis a

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hypervitaminosis A refers to any number of a large amount of toxic effects from ingesting too much... more...

MalaCards: Hypervitaminosis a is related to protein-energy malnutrition and papilloma. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are the visual cycle I (vertebrates) and Visual Cycle in Retinal Rods. The compounds n-(4-hydroxyphenyl)retinamide and purpurin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotypes are muscle and no phenotypic analysis.

Aliases & Classifications for Hypervitaminosis a

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9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:



Aliases & Descriptions:

hypervitaminosis a 9 46 63


External Ids:

Disease Ontology9 DOID:9972
ICD9CM28 278.2
SNOMED-CT59 64559002
MeSH36 D006986
ICD1026 E67.0

Related Diseases for Hypervitaminosis a

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Symptoms for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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34MalaCards
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MalaCards organs/tissues related to Hypervitaminosis a:

34
Bone, Liver, Lung, Skin, Thyroid, Testes, Adrenal gland, Breast, Pancreas, Salivary gland, Smooth muscle, Heart, Bone marrow, Eye, Kidney, Tongue, Brain, Pituitary

Animal Models for Hypervitaminosis a or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypervitaminosis a:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CDKN1B, CDKN1A, RBP4
2MP:00030128.2CDKN1B, CDKN1A, TTR
3MP:00053918.0CDKN1B, CDKN1A, RBP4, TTR
4MP:00053767.9TTR, RBP4, CDKN1A, CDKN1B

Publications for Hypervitaminosis a

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53PubMed
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Articles related to Hypervitaminosis a:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
2
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
3
Acute hypervitaminosis A in a young lady. (20395929)
2010
4
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. (16289060)
2006
5
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. (11716591)
2000
6
Assessment of risk factors for carotenodermia and cutaneous signs of hypervitaminosis A in college-aged populations. (1764358)
1991
7
Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats. (3147800)
1988
8
Hepatic and dermatologic manifestations of chronic hypervitaminosis A in adults. Report of two cases. (2937294)
1986
9
Hypervitaminosis A in a child from megadosing. (3988928)
1985
10
Ingestion of shark liver associated with pseudotumor cerebri due to acute hypervitaminosis A. (6707663)
1984
11
Discordant hepatic uptake between Tc-99m sulfur colloid and Tc-99m DISIDA in hypervitaminosis A. (6539369)
1984
12
Clinical manifestations of hypervitaminosis A in human gingiva. A case report. (6592319)
1984
13
Oxygen consumption and survival prediction in neonatal rats exposed to prenatal hypervitaminosis A. (6417812)
1983
14
Protein-calorie deficiency and vitamin indiscretion in an atopic child who developed hypervitaminosis A. (6799241)
1982
15
Morphometric study of malformations induced by hypervitaminosis A on rat fetus Meckel cartilage, maxillary bone and mandible. (6762114)
1982
16
Malformations of the eye resulting from maternal hypervitaminosis A during gestation in the rat. (6800208)
1981
17
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
18
Morphometric study of the reversibility of testicle alterations in rats submitted to hypervitaminosis A. (738845)
1978
19
Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. (20486)
1977
20
Morphologic alterations associated with decreased cerebrospinal fluid pressure in chronic bovine hypervitaminosis A. (1111381)
1975
21
Ultrastructural changes in livers of two patients with hypervitaminosis A. (4416771)
1974
22
Effect of hypervitaminosis A on immunocompetence in rats. (4549758)
1974
23
A light and electron microscopic study of the lymphomyeloid complex in hypervitaminosis A. (5075296)
1972
24
Lack of hypertrophy of the adrenal in exencephalic fetal rats subjected to hypervitaminosis A and then to maternal adrenalectomy. (4324682)
1971
25
Hypervitaminosis A dysmelia in rats. (4332598)
1971
26
Rates of formation and absorption of cerebrospinal fluid in mild chronic bovine hypervitaminosis A. (5479487)
1970
27
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
28
Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity. (5485475)
1970
29
Hepatic injury in chronic hypervitaminosis A. (5410560)
1970
30
Effects of ovariectomy and hypervitaminosis A on lysosomes of the rat conceptus. (4312014)
1969
31
Effect of hypervitaminosis A on intestinal lipids of rats. (6048389)
1967
32
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
33
Bone strength and calcium retention of rats in hypervitaminosis-A. (5178796)
1966
34
MALFORMATIONS OF THE MOUSE FETUS CAUSED BY HYPERVITAMINOSIS-A OF THE MOTHER DURING PREGNANCY. (14280198)
1965
35
ALTERATIONS IN THE LIPIDS OF BONE CAUSED BY HYPERVITAMINOSIS A AND D. (14343141)
1965
36
Carbohydrate metabolism in hypervitaminosis A. (14436609)
1959
37
Analysis of an anomalous oculodentofacial pattern in newborn rats produced by maternal hypervitaminosis A. (13631147)
1959
38
Late effects of hypervitaminosis A in the rat; disturbance and retardation in the normal growth of offspring. (13570808)
1958
39
Hypervitaminosis A; toxic reaction. (13508636)
1958
40
Hypervitaminosis A. (13425777)
1957
41
Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats. (13328832)
1956
42
Chronic hypervitaminosis A; report of a probable case in a man. (13265422)
1955
43
The biochemistry and pathology of hypervitaminosis A. (14374254)
1954
44
The activity of ascorbic acid in hypervitaminosis-A in the guinea-pig. (13128868)
1953
45
Hypervitaminosis; a study of an unusual case. (14934528)
1952
46
Hypervitaminosis A; a case report. (14890815)
1952
47
Effect of hypervitaminosis A on hepatic ascorbic acid in the rat. (14924655)
1952
48
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951
49
Hypervitaminosis A; report of a case. (14774092)
1950
50
Hypervitaminosis A; a case report. (18872296)
1948

Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG, 52PharmGKB, 61Thomson Reuters, 13EMD Millipore, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TTR, RBP4
29.3TTR, RBP4
3
Show member pathways
9.3TTR, RBP4
4
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.1CDKN1B, CDKN1A
5
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.1CDKN1A, CDKN1B
6
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.1CDKN1A, CDKN1B
79.1CDKN1B, CDKN1A
8
Show member pathways
Cell cycle39
9.1CDKN1B, CDKN1A
9
Show member pathways
9.1CDKN1A, CDKN1B
109.1CDKN1B, CDKN1A
11
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.1CDKN1A, CDKN1B
129.1CDKN1A, CDKN1B
139.1CDKN1B, CDKN1A
14
Show member pathways
9.1CDKN1B, CDKN1A
159.1CDKN1B, CDKN1A
16
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CDKN1B, CDKN1A
179.1CDKN1B, CDKN1A
18
Show member pathways
9.1CDKN1B, CDKN1A
199.1CDKN1A, CDKN1B
20
Show member pathways
9.1CDKN1B, CDKN1A
219.1CDKN1B, CDKN1A
229.1CDKN1B, CDKN1A
239.1CDKN1B, CDKN1A
249.1CDKN1A, CDKN1B
25
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.1CDKN1B, CDKN1A
26
Show member pathways
AhR pathway39
9.1CDKN1B, CDKN1A
279.1CDKN1A, CDKN1B
28
Show member pathways
DNA damage response39
9.1CDKN1B, CDKN1A
29
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
9.1CDKN1A, CDKN1B
309.1CDKN1B, CDKN1A
31
Show member pathways
9.1CDKN1A, CDKN1B
32
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.1CDKN1B, CDKN1A
339.1CDKN1B, CDKN1A
349.1CDKN1B, CDKN1A
359.1CDKN1A, CDKN1B
36
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.6CDKN1B, CDKN1A, RBP4
378.0TTR, RBP4, CDKN1A, CDKN1B
38
Show member pathways
8.0CDKN1B, CDKN1A, RBP4, TTR

Compounds for genes affiliated with Hypervitaminosis a

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB
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Compounds related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1n-(4-hydroxyphenyl)retinamide469.8CDKN1A, RBP4
2purpurin469.8RBP4, TTR
3retinyl palmitate46 2510.8RBP4, TTR
4lutein469.8RBP4, TTR
5tocopherol469.8RBP4, TTR
6cellulose acetate469.7RBP4, TTR
7phosphorus469.7TTR, RBP4
8isoleucine469.7RBP4, TTR
9betacarotene469.7RBP4, TTR
10triiodothyronine469.7RBP4, TTR
11uric acid46 2510.6RBP4, TTR
12vitamin-e469.6RBP4, TTR
13mimosine46 1210.6CDKN1A, CDKN1B
14eb 108946 6210.5CDKN1A, CDKN1B
15phorbol469.5CDKN1A, RBP4
16aphidicolin469.5CDKN1B, CDKN1A
17ciglitazone46 3010.5CDKN1B, CDKN1A
18alpha tocopherol469.5RBP4, TTR
19ns 39846 6210.5CDKN1B, CDKN1A
20indole-3-carbinol469.5CDKN1B, CDKN1A
21leptomycin b46 6210.5CDKN1A, CDKN1B
22flavopiridol46 1210.5CDKN1B, CDKN1A
23celecoxib46 62 30 52 25 1214.5CDKN1B, CDKN1A
24bortezomib46 52 1211.5CDKN1B, CDKN1A
25gefitinib46 52 1211.4CDKN1A, CDKN1B
26gemcitabine46 52 1211.4CDKN1B, CDKN1A
27lactacystin469.4CDKN1B, CDKN1A
28lovastatin46 52 62 30 1213.4CDKN1A, CDKN1B
29urea46 25 1211.3RBP4, TTR
30rosiglitazone30 46 52 25 1213.3CDKN1A, RBP4
31ornithine46 2510.3CDKN1B, RBP4
32retinoid469.3CDKN1A, RBP4, TTR
33cytarabine46 52 1211.2CDKN1B, CDKN1A
34progesterone46 30 62 25 1213.0CDKN1B, CDKN1A, RBP4
35resveratrol46 62 25 1212.0CDKN1B, CDKN1A, TTR
36agar469.0TTR, CDKN1A, CDKN1B
37paraffin468.9TTR, CDKN1A, CDKN1B
38genistein46 30 62 3 25 1213.9CDKN1B, CDKN1A, TTR
39leucine468.9TTR, RBP4, CDKN1B
40testosterone46 62 25 1211.9CDKN1B, RBP4, TTR
41cholesterol46 30 25 1211.9TTR, RBP4, CDKN1B
42dexamethasone46 52 30 1211.9TTR, RBP4, CDKN1B
43troglitazone46 30 62 1211.8CDKN1B, CDKN1A
44threonine468.8CDKN1B, CDKN1A, TTR
45alanine468.8TTR, RBP4, CDKN1B
46oxygen46 259.8RBP4, CDKN1A, CDKN1B
47glucose468.5TTR, RBP4, CDKN1B
48estrogen468.4TTR, RBP4, CDKN1A, CDKN1B
49retinoic acid46 259.4CDKN1B, CDKN1A, RBP4, TTR
50serine468.4CDKN1B, CDKN1A, RBP4, TTR

GO Terms for genes affiliated with Hypervitaminosis a

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17Gene Ontology
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Cellular components related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5CDKN1B, RBP4, TTR

Biological processes related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.6RBP4, TTR
2retinoid metabolic processGO:0015239.6RBP4, TTR
3phototransduction, visible lightGO:0076039.5TTR, RBP4
4mitotic cell cycle arrestGO:0718509.4CDKN1B, CDKN1A
5negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.4CDKN1B, CDKN1A
6negative regulation of phosphorylationGO:0423269.4CDKN1A, CDKN1B
7regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.4CDKN1B, CDKN1A
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.3CDKN1B, CDKN1A
9negative regulation of cell growthGO:0303089.3CDKN1B, CDKN1A
10cell cycle arrestGO:0070509.2CDKN1B, CDKN1A
11phosphatidylinositol-mediated signalingGO:0480159.2CDKN1B, CDKN1A
12G1/S transition of mitotic cell cycleGO:0000829.1CDKN1A, CDKN1B
13epidermal growth factor receptor signaling pathwayGO:0071739.1CDKN1B, CDKN1A
14fibroblast growth factor receptor signaling pathwayGO:0085439.0CDKN1B, CDKN1A
15Fc-epsilon receptor signaling pathwayGO:0380958.8CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1CDKN1B, CDKN1A
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048618.8CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypervitaminosis a

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet