MCID: HYP058
MIFTS: 39

Hypervitaminosis a malady

Category: Metabolic diseases

Aliases & Classifications for Hypervitaminosis a

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Aliases & Descriptions for Hypervitaminosis a:

Name: Hypervitaminosis a 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:9972
ICD1030 E67.0
SNOMED-CT62 64559002
ICD9CM32 278.2
MeSH39 D006986

Summaries for Hypervitaminosis a

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Wikipedia:71 Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise... more...

MalaCards based summary: Hypervitaminosis a is related to hepatitis and integumentary system benign neoplasm. An important gene associated with Hypervitaminosis a is RBP4 (Retinol Binding Protein 4), and among its related pathways are the visual cycle I (vertebrates) and Retinoid cycle disease events. Affiliated tissues include bone, liver and lung, and related mouse phenotypes are Decreased viability and renal/urinary system.

Related Diseases for Hypervitaminosis a

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Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Symptoms & Phenotypes for Hypervitaminosis a

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GenomeRNAi Phenotypes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00381-A-110.1MGP, RBP4

MGI Mouse Phenotypes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4CDKN1A, CDKN1B, MGP, RARG, SLCO2A1
2MP:00053918.4CDKN1A, CDKN1B, RARG, RBP4, TTR
3MP:00053858.1CDKN1A, CDKN1B, MGP, RARG, RBP4, SLCO2A1
4MP:00053767.7CDKN1A, CDKN1B, MGP, RARG, RBP4, SLCO2A1

Drugs & Therapeutics for Hypervitaminosis a

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Drugs for Hypervitaminosis a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Vitamin Aapproved, nutraceutical, vet_approvedPhase 1, Phase 249211103-57-4, 68-26-8445354
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
.alpha.lin
.alpha.sterol
.beta.-Retinol
11103-57-4
13123-33-6
1341-18-0
1406-67-3
17104-91-5
1rbp
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
4-06-00-04133 (Beilstein Handbook Reference)
53637-36-8
5979-23-7
68-26-8
95144_FLUKA
95144_SIGMA
95146_FLUKA
95146_SIGMA
A-Mulsal
A-Sol
A-Vi-Pel
A-Vitan
AC-11701
AC1L9HU3
AC1Q7BU9
ACON
ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)
AR-1L3057
ATAV
Afaxin
Agiolan
Agoncal
Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
Alcovit A
All Trans Retinol
All-trans retinol
All-trans-Retinol
Alphalin
Alphasterol
Anatola
Anatola A
Anti-infective vitamin
Antixerophthalmic vitamin
Antixerophthalmisches Vitamin
Aoral
Apexol
Apostavit
Aquasol A Parenteral
Aquasynth
Atars
Avibon
Avita
Avitol
Axerol
Axerophthol
Axerophtholum
BIDD:PXR0102
BRN 0403040
Bentavit A
Biosterol
C00473
C17276
C20H30O
CCRIS 5444
CHEBI:17336
CHEMBL986
CID445354
Chocola A
Cylasphere
D014801
D06543
DB00162
Del-VI-A
Disatabs Tabs
Dofsol
Dohyfral A
EINECS 200-683-7
EINECS 234-328-2
Epiteliol
HMS1921B04
HMS2092L13
HMS501I08
HSDB 815
Hi-A-Vita
Homagenets Aoral
Homagenets aorl
Hydrovit A
IDI1_000486
LMPR01090001
LPK
LS-1578
Lard Factor
M.V.C. 9+3
M.V.I.-12
 
MLS001066379
MLS001074751
MolPort-001-785-962
Mvc Plus
Myvpack
NCGC00091784-01
NCGC00091784-02
NCGC00091784-03
NCGC00091784-04
NCGC00091784-05
NCGC00091784-06
NSC 122759
NSC122759
Nio-A-Let
Oleovitamin A
Ophthalamin
Plivit A
Prepalin
R7632_SIGMA
Retin-11,12-t2-ol (9CI)
Retinol
Retinol [INN:BAN]
Retinol solution
Retinol, all-trans- (8CI)
Retinol-(cellular-retinol-binding-protein)
Retinolo
Retinolo [DCIT]
Retinolum
Retinolum [INN-Latin]
Retrovitamin A
Ro-a-vit
Rovimix A 500
SDCCGMLS-0066724.P001
SMP2_000102
SMR000112036
SPECTRUM1501203
ST057232
Sehkraft A
Solu-A
Spectrum5_000993
Spectrum5_001997
Super A
Testavol
Testavol S
Thalasphere
UNII-81G40H8B0T
UNII-G2SH0XKK91
Vaflol
Vafol
Veroftal
Vi-.alpha.
Vi-Alpha
Vi-Dom-A
Vi-a
Vio-A
Vitamin A
Vitamin A (Feed)
Vitamin A (USP)
Vitamin A alcohol
Vitamin A alcohol (VAN)
Vitamin A cryst
Vitamin A1
Vitamin A1 alcohol
Vitamin A1 alcohol, all trans
Vitamin- A
Vitamin- A alcohol
Vitamin- A alcohol solution
Vitamin- A1
Vitamin-?A
Vitamin-?A alcohol
Vitamin-?A alcohol solution
Vitamin-?A1
Vitamine A
Vitaminum A
Vitavel A
Vitavel-A
Vitpex
Vogan
Vogan-Neu
Vogan-nu
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Wachstumsvitamin
ZINC03831417
Zinosan N
[11,12-3H]-Retinol
alin
all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-Retinol
all-trans-Retinyl alcohol
all-trans-Vitamin A
all-trans-Vitamin A alcohol
all-trans-Vitamin A1
all-trans-retinol
all-trans-retinyl alcohol
all-trans-vitamin A alcohol
b-Retinol
beta-Retinol
retinol
tROL
trans-Retinol
trans-Retinol acid (Vitamin A)
trans-Vitamin A alcohol
trans-retinol
2
acetic acidapproved, NutraceuticalPhase 1, Phase 211264-19-7176
Synonyms:
Acetate
Acetic acid, glacial
Aceticum acidum
Essigsäure
Ethanoat
Ethanoate
Ethanoic acid
Ethoic acid
Ethylate
 
Ethylic acid
Glacial acetate
Glacial acetic acid
HOAc
Kyselina octova
Methanecarboxylate
Methanecarboxylic acid
Vinegar
Vinegar acid
acide acétique
3Retinol palmitatePhase 1, Phase 2492
4Protective AgentsPhase 1, Phase 27443
5MicronutrientsPhase 1, Phase 26001
6VitaminsPhase 1, Phase 25282
7AntioxidantsPhase 1, Phase 23050
8Trace ElementsPhase 1, Phase 26001
9
Retinol acetatePhase 1, Phase 2107127-47-910245972
Synonyms:
13-cis-Retinyl acetate
Acetateall-trans-Retinol
Acetic acid, retinyl ester
All-trans-Retinyl acetate
All-trans-retinol acetate
All-trans-retinyl acetate
All-trans-retinylacetate
All-trans-vitamin a acetate
Crystalets
Davitan A 650
Myvak (van)
Myvax (van)
O(15)-Acetylretinol
O~15~-Acetyl-retinol
O~15~-Acetylretinol
 
RETINOL ACETATE (SEE RETINOIDPROJECTS 1 AND 3)
Retinol acetate
Retinol acetate (JP15)
Retinol, acetate
Retinol, acetate, all-trans- (8CI)
Retinol, acetate, labeled with tritium
Retinyl acetate
Trans-retinyl acetate
Trans-vitamin a acetate
Vitamin A acetate
Vitamin A1 acetate
Vitamin a acetate (tritiated)
Vitamin a acetate (van)
Vitamin a alcohol acetate
Vitamin a ester
Vitamin a, acetate
10Adjuvants, ImmunologicPhase 1, Phase 22554
11retinolNutraceuticalPhase 1, Phase 2492
12SunflowerNutraceuticalPhase 1, Phase 2112
13Liver Extracts4067

Interventional clinical trials:

idNameStatusNCT IDPhase
1Novel Isotope Dilution Technique to Assess Vitamin A Status and Hypervitaminosis ARecruitingNCT03000543Phase 1, Phase 2
2Total Body Vitamin A Before and After Vitamin A Supplementation in a Community Where Liver is Frequently EatenCompletedNCT02915731

Search NIH Clinical Center for Hypervitaminosis a


Cochrane evidence based reviews: hypervitaminosis a

Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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MalaCards organs/tissues related to Hypervitaminosis a:

36
Bone, Liver, Lung, Skin, Thyroid, Testes, Adrenal gland

Publications for Hypervitaminosis a

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Articles related to Hypervitaminosis a:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Hypervitaminosis a causing hypercalcemia in cystic fibrosis. Case report and focused review. (25188737)
2014
2
Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia. (25119682)
2014
3
Hypervitaminosis A-induced hepatic fibrosis in a cat. (24563496)
2014
4
Hypercalcaemia Secondary to Hypervitaminosis A in a Patient with Chronic Renal Failure. (25303202)
2014
5
Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats. (23591666)
2012
6
Hypercalcemia, hypervitaminosis A and 3-epi-25-OH-D3 levels after consumption of an "over the counter" vitamin D remedy. a case report. (22426357)
2012
7
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
8
Hypervitaminosis A in lambs fed milk replacer. (22952133)
2012
9
Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system. (23028466)
2012
10
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
11
Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A. (21306609)
2011
12
Correcting a misrepresentation of hypervitaminosis A attributed to Herbalife product consumption. (21315714)
2011
13
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. (19619235)
2010
14
Orally ingested (13)C(2)-retinol is incorporated into hepatic retinyl esters in a nonhuman primate (Macaca mulatta) model of hypervitaminosis A. (20158952)
2010
15
The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A. (19808077)
2010
16
Hypervitaminosis A inducing intra-hepatic cholestasis--a rare case report. (19944093)
2010
17
Acute hypervitaminosis A in a young lady. (20395929)
2010
18
Hypervitaminosis A altering the lipid profile in a hypercholesterolemic patient. (21291816)
2009
19
Dysphagia and hypervitaminosis A: cervical hyperostosis. (19289294)
2009
20
Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A. (19710158)
2009
21
Hypervitaminosis A in experimental nonhuman primates: evidence, causes, and the road to recovery. (19484706)
2009
22
Hypervitaminosis a in pediatric hematopoietic stem cell patients requiring renal replacement therapy. (19033221)
2008
23
Hypervitaminosis A-induced premature closure of epiphyses (physeal obliteration) in humans and calves (hyena disease): a historical review of the human and veterinary literature. (17909784)
2007
24
Central physeal arrests as a manifestation of hypervitaminosis A. (17414024)
2007
25
Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. (16448456)
2006
26
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. (16289060)
2006
27
Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta Mouse). (16054864)
2005
28
Hypercalcemia caused by iatrogenic hypervitaminosis A. (15635357)
2005
29
Hypervitaminosis A in the cat: a case report and review of the literature. (15994105)
2005
30
Polar hysteria: an expression of hypervitaminosis A. (15543093)
2004
31
Hypervitaminosis A and fractures. (12540650)
2003
32
Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture. (14608074)
2003
33
Hypervitaminosis A and the redistribution of calcium in the neutrophil of chronic renal failure patients on maintenance hemodialysis treatment. (12356198)
2002
34
Infant hypervitaminosis A causes severe anemia and thrombocytopenia: evidence of a retinol-dependent bone marrow cell growth inhibition. (11877274)
2002
35
Subclinical hypervitaminosis A causes fragile bones in rats. (12531562)
2002
36
Hyperostotic polyarthropathy in a rabbit--a suspected case of chronic hypervitaminosis A from a diet of carrots. (11702930)
2001
37
Hypervitaminosis A and bone. (10860393)
2000
38
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. (11716591)
2000
39
Benign intracranial hypertension associated with hypervitaminosis A. (9503739)
1998
40
Alterations in kidney enzyme pattern in acute hypervitaminosis A. (9830487)
1998
41
Local disappearance of epiphyseal growth plates in rats with hypervitaminosis A. (9713809)
1998
42
Mouse palatal width growth rates as an "at risk" factor in the development of cleft palate induced by hypervitaminosis A. (9493079)
1997
43
Hypervitaminosis A as a complication of treatment for neuroblastoma. (8599009)
1996
44
Hypervitaminosis - a. (20947982)
1996
45
Hypervitaminosis A in two hemodialysis patients. (7847365)
1995
46
Effects of hypervitaminosis A on rat fetus esophagus smooth muscle cells. (8580885)
1995
47
Effect of hypervitaminosis A on intestinal digestive & absorptive functions in rat. (8063349)
1994
48
Hypervitaminosis A in a cat. (1639706)
1992
49
Hypervitaminosis A and reproductive disorders in rabbits. (1320154)
1992
50
Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A. (1612491)
1992

Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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GO Terms for genes affiliated with Hypervitaminosis a

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Cellular components related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.9CDKN1A, CDKN1B, RBP4, TTR

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.2CDKN1A, CDKN1B
2mitotic cell cycle arrestGO:007185010.2CDKN1A, CDKN1B
3negative regulation of cyclin-dependent protein kinase activityGO:190403010.2CDKN1A, CDKN1B
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.2CDKN1A, CDKN1B
5negative regulation of phosphorylationGO:004232610.2CDKN1A, CDKN1B
6positive regulation of cell deathGO:001094210.2CDKN1A, CDKN1B
7regulation of cyclin-dependent protein serine/threonine kinase activityGO:000007910.2CDKN1A, CDKN1B
8retinoid metabolic processGO:000152310.2RBP4, TTR
9response to retinoic acidGO:003252610.1RARG, RBP4
10positive regulation of programmed cell deathGO:004306810.1CDKN1A, RARG
11retinol metabolic processGO:00425729.8RBP4, TTR

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin bindingGO:003033210.1CDKN1A, CDKN1B
2cyclin-dependent protein serine/threonine kinase activityGO:000469310.1CDKN1A, CDKN1B
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:000486110.1CDKN1A, CDKN1B
4protein kinase inhibitor activityGO:00048609.6CDKN1A, CDKN1B

Sources for Hypervitaminosis a

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet