MCID: HYP058
MIFTS: 38

Hypervitaminosis a malady

Metabolic category

Summaries for Hypervitaminosis a

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hypervitaminosis A refers to the effects of excessive vitamin A (specifically retinoid) intake. more...

MalaCards: Hypervitaminosis a is related to hypervitaminosis d and hypercalcemia. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are Vitamin A and carotenoid metabolism and Class I PI3K signaling events mediated by Akt. The compounds purpurin and retinyl palmitate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and smooth muscle, and related mouse phenotype vision/eye.

Aliases & Classifications for Hypervitaminosis a

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

hypervitaminosis a 8 45 61


External Ids:

Disease Ontology8 DOID:9972
ICD9CM27 278.2
SNOMED-CT57 64559002
MeSH35 D006986
ICD1025 E67.0

Related Diseases for Hypervitaminosis a

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

hypervitaminosis d

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 30)
idRelated DiseaseScoreTop Affiliating Genes
1hypervitaminosis d10.9
2hypercalcemia10.5
3cleft palate10.4
4pseudotumor cerebri10.3
5exencephaly10.3
6cystic fibrosis10.2
7acne10.2
8hypoxia10.2
9gout10.0
10brain compression10.0
11spondylosis10.0
12portal hypertension10.0
13alagille syndrome10.0
14protein c deficiency10.0
15scurvy10.0
16hepatitis a10.0
17adenoma10.0
18alopecia10.0
19thrombocytopenia10.0
20viral hepatitis10.0
21young syndrome10.0
22neural tube defects10.0
23dysphagia10.0
24thyroid adenoma10.0
25atherosclerosis10.0RBP4
26keratomalacia10.0TTR, RBP4
27hyperparathyroidism10.0CDKN1B
28measles10.0RBP4
29protein-energy malnutrition10.0RBP4, TTR
30papilloma10.0CDKN1A, CDKN1B

Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Clinical Features for Hypervitaminosis a

Drugs & Therapeutics for Hypervitaminosis a

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypervitaminosis a

Search CenterWatch for Hypervitaminosis a

Genetic Tests for Hypervitaminosis a

Anatomical Context for Hypervitaminosis a

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypervitaminosis a:

33
Bone marrow, Brain, Smooth muscle, Skeletal muscle, Kidney, Liver, Pancreas, Thyroid, Salivary gland, Adrenal gland, Placenta, B cells, Fetal brain, Fetal liver, Fetal thyroid, Pituitary

Animal Models for Hypervitaminosis a or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hypervitaminosis a:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TTR, CYP26B1, CDKN1B, CDKN1A, RBP4

Publications for Hypervitaminosis a

Sources:
51PubMed
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Articles related to Hypervitaminosis a:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system. (23028466)
2012
2
Correcting a misrepresentation of hypervitaminosis A attributed to Herbalife product consumption. (21315714)
2011
3
Acute hypervitaminosis A in a young lady. (20395929)
2010
4
Hypervitaminosis A altering the lipid profile in a hypercholesterolemic patient. (21291816)
2009
5
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. (16731043)
2006
6
Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta Mouse). (16054864)
2005
7
Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture. (14608074)
2003
8
In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis. (12654005)
2003
9
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. (12002522)
2002
10
Alterations in kidney enzyme pattern in acute hypervitaminosis A. (9830487)
1998
11
Hypervitaminosis D in institutionalized elderly in Buenos Aires]. (9435366)
1997
12
Effect of hypervitaminosis A on intestinal digestive & absorptive functions in rat. (8063349)
1994
13
Assessment of risk factors for carotenodermia and cutaneous signs of hypervitaminosis A in college-aged populations. (1764358)
1991
14
Ingestion of shark liver associated with pseudotumor cerebri due to acute hypervitaminosis A. (6707663)
1984
15
Inhibiting effects of hypervitaminosis A on development of fetal rat adrenal glands. (6543180)
1984
16
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. (6837312)
1983
17
Hypervitaminosis A. Case report in an adolescent soccer player. (6829839)
1983
18
Morphometric study of the reversibility of pancreas alterations in rats submitted to hypervitaminosis A. (7121845)
1982
19
Hypervitaminosis A unmasked by acute viral hepatitis. (7198070)
1982
20
Hypervitaminosis A and matrix alterations in maxillary explants from 16-day rat embryos. (7385053)
1980
21
Hypervitaminosis A in a patient with alopecia receiving renal dialysis. (453904)
1979
22
Ascorbic acid effect on hypervitaminosis A in rats. (711381)
1978
23
Morphometric study of testicle alterations in rats submitted to hypervitaminosis A. (570178)
1978
24
Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide. (1277139)
1976
25
Morphologic alterations associated with decreased cerebrospinal fluid pressure in chronic bovine hypervitaminosis A. (1111381)
1975
26
Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites. (4843409)
1974
27
Hypervitaminosis A in rats. Varying responses due to different forms, doses, and routes of administration. (4708005)
1973
28
Chronic adult hypervitaminosis A with hypercalcemia. (4641958)
1972
29
Interdependence of fetal anomalies and placental impairment following maternal hypervitaminosis D and hypercortisonism. (4548304)
1972
30
Rates of formation and absorption of cerebrospinal fluid in mild chronic bovine hypervitaminosis A. (5479487)
1970
31
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
32
Hypervitaminosis D, anaemia and renal failure. (5476149)
1970
33
Variations in teratogenic response to hypervitaminosis A in three strains of the albino rat. (5804862)
1969
34
Chronic hypervitaminosis A in an adult. (6071832)
1967
35
Mesodermal alterations induced by hypervitaminosis A. (5964276)
1966
36
CHRONIC HYPERVITAMINOSIS A. REPORT OF A CASE IN AN ADULT. (14051363)
1963
37
Acute hypervitaminosis A in guinea pigs, I, Effects on acid hydroalases. (13999783)
1963
38
Experimental arteriosclerosis due to hypervitaminosis D. (13712151)
1960
39
Analysis of an anomalous oculodentofacial pattern in newborn rats produced by maternal hypervitaminosis A. (13631147)
1959
40
The effect of hypervitaminosis A upon the incisor and molar teeth, the alveolar bone, and temporomandibular joint of weanling rats. (13851315)
1959
41
The antagonism between cortisone and vitamin D: experiments on hypervitaminosis D inrats. (13539297)
1958
42
Influence of 4-methyl-2-thiouracil on the teratogenic activity of hypervitaminosis-A. (13541340)
1958
43
Effect of vitamin B complex on the teratogenic activity of hypervitaminosis A. (13590177)
1958
44
Hypervitaminosis A; report of a case in an adult. (13331778)
1956
45
The hypervitaminosis-A syndrome in adrenalectomized rats; skeletal changes in weanling rats with and without cortisone. (14397941)
1955
46
Acute hypervitaminosis A of the infant; its clinical manifestation with benign acute hydrocephalus and pronounced bulge of the fontanel; a clinical and biologic study. (13157631)
1954
47
Hypervitaminosis A: report of a case in an adult male. (13065995)
1953
48
Hypervitaminosis A and ascorbic acid. (13079856)
1953
49
The action of vitamin K in hypervitaminosis A. (16748217)
1947
50
The Pathology of Hypovitaminosis and Hypervitaminosis D and its Application to an Explanation of the Mode of Action of the Vitamin. (19988301)
1931

Genetic Variations for Hypervitaminosis a

Expression for genes affiliated with Hypervitaminosis a

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 54Reactome
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Pathways related to Hypervitaminosis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP26B1, RBP4
29.6CDKN1B, CDKN1A
39.6CDKN1B, CDKN1A
4
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.6CDKN1B, CDKN1A
5
Hide members
9.3CDKN1B, CDKN1A, RBP4
69.0RBP4, CDKN1A, CDKN1B, TTR

Compounds for genes affiliated with Hypervitaminosis a

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1purpurin4510.2TTR, RBP4
2retinyl palmitate45 2411.1RBP4, TTR
3lutein4510.1RBP4, TTR
4tocopherol4510.1RBP4, TTR
5cellulose acetate4510.0TTR, RBP4
6mimosine45 1110.9CDKN1B, CDKN1A
7eb 108945 6010.8CDKN1A, CDKN1B
8aphidicolin459.7CDKN1B, CDKN1A
9ciglitazone45 2910.7CDKN1A, CDKN1B
10ns 39845 6010.6CDKN1B, CDKN1A
11indole-3-carbinol459.6CDKN1B, CDKN1A
12retinoid459.6TTR, CDKN1A, RBP4
13resveratrol45 60 11 2412.6TTR, CDKN1B, CDKN1A
14agar459.5TTR, CDKN1B, CDKN1A
15threonine458.6CDKN1A, CDKN1B, TTR, SDS
16serine458.1SDS, TTR, CDKN1B, CDKN1A, RBP4

GO Terms for genes affiliated with Hypervitaminosis a

Sources:
16Gene Ontology
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Biological processes related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.9TTR, RBP4
2mitotic cell cycle arrestGO:0718509.7CDKN1B, CDKN1A
3gluconeogenesisGO:0060949.6SDS, RBP4
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN1A, CDKN1B
5negative regulation of phosphorylationGO:0423269.3CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypervitaminosis a

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet