MCID: HYP058
MIFTS: 42

Hypervitaminosis a malady

Metabolic diseases category

Summaries for Hypervitaminosis a

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypervitaminosis A refers to any number of a large amount of toxic effects from ingesting too much... more...

MalaCards: Hypervitaminosis a is related to protein-energy malnutrition and papilloma. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are Vitamin A and carotenoid metabolism and Class I PI3K signaling events mediated by Akt. The compounds purpurin and retinyl palmitate have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotype vision/eye.

Aliases & Classifications for Hypervitaminosis a

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

hypervitaminosis a 8 44 60


External Ids:

Disease Ontology8 DOID:9972
ICD9CM27 278.2
SNOMED-CT56 64559002
MeSH34 D006986
ICD1025 E67.0

Related Diseases for Hypervitaminosis a

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17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition29.9RBP4, TTR
2papilloma29.9CDKN1B, CDKN1A
3hepatitis a10.5
4hepatitis10.5
5hypercalcemia10.4
6cleft palate10.4
7hypertension10.4
8hyperostosis10.3
9intracranial hypertension10.3
10pseudotumor cerebri10.3
11hypervitaminosis d10.3
12thyroiditis10.2
13cystic fibrosis10.1
14acne10.1
15cervicitis10.1
16atherosclerosis10.0RBP4
17gout10.0
18hepatitis c10.0
19brain compression10.0
20choroiditis10.0
21spondylosis10.0
22portal hypertension10.0
23alagille syndrome10.0
24protein c deficiency10.0
25scurvy10.0
26adenoma10.0
27alopecia10.0
28breast cancer10.0
29cholestasis10.0
30goiter10.0
31hydrocephalus10.0
32neuroblastoma10.0
33nutritional deficiency disease10.0
34overnutrition10.0
35papilledema10.0
36thrombocytopenia10.0
37vaginitis10.0
38viral hepatitis10.0
39keratomalacia10.0TTR, RBP4
40hyperparathyroidism10.0CDKN1B
41measles10.0RBP4

Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Clinical Features for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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32MalaCards
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MalaCards organs/tissues related to Hypervitaminosis a:

32
Bone, Liver, Lung, Thyroid, Testes, Skin, Adrenal gland, Kidney, Breast, Tongue, Bone marrow, Salivary gland, Pancreas, Smooth muscle, Heart, Brain, Eye, Pituitary

Animal Models for Hypervitaminosis a or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypervitaminosis a:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TTR, CYP26B1, CDKN1B, CDKN1A, RBP4

Publications for Hypervitaminosis a

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50PubMed
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Articles related to Hypervitaminosis a:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Correcting a misrepresentation of hypervitaminosis A attributed to Herbalife product consumption. (21315714)
2011
2
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. (16289060)
2006
3
Hypervitaminosis A and fractures. (12540650)
2003
4
Hypervitaminosis A and the redistribution of calcium in the neutrophil of chronic renal failure patients on maintenance hemodialysis treatment. (12356198)
2002
5
Hyperostotic polyarthropathy in a rabbit--a suspected case of chronic hypervitaminosis A from a diet of carrots. (11702930)
2001
6
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. (11716591)
2000
7
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. (2109995)
1990
8
Clinical manifestations of hypervitaminosis A in human gingiva. A case report. (6592319)
1984
9
Inhibiting effects of hypervitaminosis A on development of fetal rat adrenal glands. (6543180)
1984
10
What is your diagnosis? Soft tissue calcifications, suggestive of hypervitaminosis A. (6654731)
1983
11
Hypervitaminosis A enhances hepatotoxicity of ethanol in rats. (6353294)
1983
12
Protracted hypervitaminosis A following long-term, low-level intake. (6460882)
1982
13
Hypervitaminosis A and matrix alterations in maxillary explants from 16-day rat embryos. (7385053)
1980
14
Acne, hypervitaminosis A and hypercalcaemia. A case report. (153590)
1978
15
Morphometric study of testicle alterations in rats submitted to hypervitaminosis A. (570178)
1978
16
Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide. (1277139)
1976
17
Placental agenesis, embryonal hydraemia, embryolethality and acute hypervitaminosis A in rats. (999789)
1976
18
Ultrastructural changes in livers of two patients with hypervitaminosis A. (4416771)
1974
19
Skeletal deformities following chronic hypervitaminosis A; a case report. (4436364)
1974
20
Formation and absorption of cerebrospinal fluid in adult goats with hypo- and hypervitaminosis A. (4809598)
1974
21
An electron microscopic study of the effects of hypervitaminosis A on the maternal-embryonic relationship of the rat at 8 days of pregnancy. (4713336)
1973
22
Prevention of vascular lesions by chondroitin sulfate A in the coronary artery and aorta of rats induced by a hypervitaminosis D, cholesterol-containing diet. (5069576)
1972
23
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
24
Prevention of hypervitaminosis A by spironolactone and anabolic steroids. (5504690)
1970
25
Teratogenic effects of hypervitaminosis A in the hamster and the guinea pig. (5416756)
1970
26
Variations in teratogenic response to hypervitaminosis A in three strains of the albino rat. (5804862)
1969
27
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
28
Role of hypophysis in development of adrenal hypertrophy in rats with hypervitaminosis A. (5215806)
1966
29
Hypervitaminosis D.--A case report. (5922345)
1966
30
MALFORMATIONS OF THE MOUSE FETUS CAUSED BY HYPERVITAMINOSIS-A OF THE MOTHER DURING PREGNANCY. (14280198)
1965
31
Hypervitaminosis A and tissue fatty acids. (5867008)
1965
32
Hypervitaminosis A and mast cells. A study of the interrelationship of mast cells and vitamin A in vivo and in vitro. (13967630)
1963
33
Acute hypervitaminosis A in guinea pigs. II. Effects on delayed-type hypersensitivity. (13995247)
1963
34
Hypervitaminosis A. (13943414)
1962
35
The amelioration of hypervitaminosis D in rats with vitamin A. (13879694)
1962
36
Vitamin A acid and hypervitaminosis A. (13776588)
1960
37
Carbohydrate metabolism in hypervitaminosis A. (14436609)
1959
38
Oxidative processes in hypervitaminosis A in albino rats. (13661357)
1959
39
Late effects of hypervitaminosis A in the rat; disturbance and retardation in the normal growth of offspring. (13570808)
1958
40
Hypervitaminosis A; toxic reaction. (13508636)
1958
41
Hypervitaminosis A: its broadening spectrum. (13559160)
1958
42
Infantile cortical hyperostosis; report of two cases with review of points of differential diagnosis from hypervitaminosis A. (13354851)
1956
43
Two Cases of Hypervitaminosis A. (19993869)
1955
44
Hypervitaminosis A and the skeleton of growing chicks. (14932587)
1952
45
Hypervitaminosis a; report of an unusual case with marked craniotabes. (14911249)
1951
46
Hypervitaminosis A; report of a case in an adult. (14832059)
1951
47
Hypervitaminosis A; report of a case. (14774092)
1950
48
The effects of a vitaminosis and hypervitaminosis A upon the incisor teeth and incisal alveolar bone of rats. (18128149)
1949
49
Hypervitaminosis A; report of two cases in infants. (18882268)
1948
50
Multiple calcinosis associated with hypervitaminosis D; report of a case. (18914973)
1948

Genetic Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome
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Pathways related to Hypervitaminosis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP26B1, RBP4
29.6CDKN1B, CDKN1A
39.6CDKN1B, CDKN1A
4
Development Thrombopoetin signaling via JAK-STAT pathway
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9.6CDKN1B, CDKN1A
5
Hide members
9.3CDKN1B, CDKN1A, RBP4
69.0RBP4, CDKN1A, CDKN1B, TTR

Compounds for genes affiliated with Hypervitaminosis a

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1purpurin4410.2TTR, RBP4
2retinyl palmitate44 2411.1RBP4, TTR
3lutein4410.1RBP4, TTR
4tocopherol4410.1RBP4, TTR
5cellulose acetate4410.0TTR, RBP4
6mimosine44 1110.9CDKN1B, CDKN1A
7eb 108944 5910.8CDKN1A, CDKN1B
8aphidicolin449.7CDKN1B, CDKN1A
9ciglitazone44 2810.7CDKN1A, CDKN1B
10ns 39844 5910.6CDKN1B, CDKN1A
11indole-3-carbinol449.6CDKN1B, CDKN1A
12retinoid449.6TTR, CDKN1A, RBP4
13resveratrol44 59 11 2412.6TTR, CDKN1B, CDKN1A
14agar449.5TTR, CDKN1B, CDKN1A
15threonine448.6CDKN1A, CDKN1B, TTR, SDS
16serine448.1SDS, TTR, CDKN1B, CDKN1A, RBP4

GO Terms for genes affiliated with Hypervitaminosis a

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16Gene Ontology
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Biological processes related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.9TTR, RBP4
2mitotic cell cycle arrestGO:0718509.7CDKN1B, CDKN1A
3gluconeogenesisGO:0060949.6SDS, RBP4
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN1A, CDKN1B
5negative regulation of phosphorylationGO:0423269.3CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypervitaminosis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet