MCID: HYP058
MIFTS: 42

Hypervitaminosis a malady

Metabolic diseases category

Summaries for Hypervitaminosis a

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypervitaminosis A refers to any number of a large amount of toxic effects from ingesting too much... more...

MalaCards: Hypervitaminosis a is related to protein-energy malnutrition and papilloma. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are Vitamin A and carotenoid metabolism and Class I PI3K signaling events mediated by Akt. The compounds purpurin and retinyl palmitate have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotype vision/eye.

Aliases & Classifications for Hypervitaminosis a

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

hypervitaminosis a 8 44 60


External Ids:

Disease Ontology8 DOID:9972
ICD9CM27 278.2
SNOMED-CT56 64559002
MeSH34 D006986
ICD1025 E67.0

Related Diseases for Hypervitaminosis a

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17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition29.9RBP4, TTR
2papilloma29.9CDKN1B, CDKN1A
3hepatitis a10.5
4hepatitis10.5
5hypercalcemia10.4
6cleft palate10.4
7hypertension10.4
8hyperostosis10.3
9intracranial hypertension10.3
10pseudotumor cerebri10.3
11hypervitaminosis d10.3
12thyroiditis10.2
13cystic fibrosis10.1
14acne10.1
15cervicitis10.1
16atherosclerosis10.0RBP4
17gout10.0
18hepatitis c10.0
19brain compression10.0
20choroiditis10.0
21spondylosis10.0
22portal hypertension10.0
23alagille syndrome10.0
24protein c deficiency10.0
25scurvy10.0
26adenoma10.0
27alopecia10.0
28breast cancer10.0
29cholestasis10.0
30goiter10.0
31hydrocephalus10.0
32neuroblastoma10.0
33nutritional deficiency disease10.0
34overnutrition10.0
35papilledema10.0
36thrombocytopenia10.0
37vaginitis10.0
38viral hepatitis10.0
39keratomalacia10.0TTR, RBP4
40hyperparathyroidism10.0CDKN1B
41measles10.0RBP4

Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Clinical Features for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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32MalaCards
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MalaCards organs/tissues related to Hypervitaminosis a:

32
Bone, Liver, Lung, Thyroid, Testes, Skin, Adrenal gland, Kidney, Breast, Tongue, Bone marrow, Salivary gland, Pancreas, Smooth muscle, Heart, Brain, Eye, Pituitary

Animal Models for Hypervitaminosis a or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypervitaminosis a:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TTR, CYP26B1, CDKN1B, CDKN1A, RBP4

Publications for Hypervitaminosis a

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50PubMed
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Articles related to Hypervitaminosis a:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
2
Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats. (23591666)
2012
3
Acute hypervitaminosis A in a young lady. (20395929)
2010
4
Orally ingested (13)C(2)-retinol is incorporated into hepatic retinyl esters in a nonhuman primate (Macaca mulatta) model of hypervitaminosis A. (20158952)
2010
5
Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A. (19710158)
2009
6
Dysphagia and hypervitaminosis A: cervical hyperostosis. (19289294)
2009
7
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. (16699077)
2006
8
Hypervitaminosis A in the cat: a case report and review of the literature. (15994105)
2005
9
Hypervitaminosis A and bone. (10860393)
2000
10
Hepatic hypervitaminosis A: a familial observation. (2324882)
1990
11
Discordant hepatic uptake between Tc-99m sulfur colloid and Tc-99m DISIDA in hypervitaminosis A. (6539369)
1984
12
Oxygen consumption and survival prediction in neonatal rats exposed to prenatal hypervitaminosis A. (6417812)
1983
13
Hypervitaminosis A. Case report in an adolescent soccer player. (6829839)
1983
14
Morphometric study of the reversibility of pancreas alterations in rats submitted to hypervitaminosis A. (7121845)
1982
15
Malformations of genitourinary system resulting from maternal hypervitaminosis A in rat. (7239564)
1981
16
Development of hypervitaminosis A in a patient on long-term parenteral hyperalimentation. (6784095)
1981
17
Teratogenic effects of hypervitaminosis A: an experimental study. (7341729)
1980
18
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
19
Effect of hypervitaminosis A on the Harderian gland in rats. A morphologic and morphometric study. (357318)
1978
20
Early changes in the mouse neuroepithelium preceding exencephaly induced by hypervitaminosis A. (715727)
1978
21
Hypervitaminosis D and metastatic pulmonary calcification in a cow. (204097)
1977
22
Abnormal liver function in chronic hypervitaminosis A. (879140)
1977
23
Microsomal enzyme inducers and hypervitaminosis A in rats. (946392)
1976
24
Some behavioral effects of maternal hypervitaminosis A in rats. (4477412)
1974
25
Hypercalcemia due to hypervitaminosis A. (4273771)
1974
26
Editorial: Hypervitaminosis A. (4810330)
1974
27
Chronic adult hypervitaminosis A with hypercalcemia. (4641958)
1972
28
Effect of hypervitaminosis A on adrenal corticosteroids. (4662213)
1972
29
An ultrastructural study of the effect of hypervitaminosis A acid on the cartilage of the rabbit's ear. (5040875)
1972
30
Experimental formation of goiter in exencephalic fetal rats subjected to maternal hypervitaminosis A. (4991824)
1971
31
Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity. (5485475)
1970
32
Production of cleft palate with dexamethasone and hypervitaminosis A in rat embryos. (4320730)
1970
33
Histology of onset of skin changes in hypervitaminosis A in chickens. (5784665)
1969
34
Qualitative and quantitative osteoblastic activity in chronic porcine hypervitaminosis A. (5354046)
1969
35
Skeletal abnormalities in the hindlimbs of young cats as a result of hypervitaminosis A. (5643096)
1968
36
Mesodermal alterations induced by hypervitaminosis A. (5964276)
1966
37
Congenital malformations of the jaws and related structures in exencephalic mouse embryos with anomalous molar germs, induced by hypervitaminosis A. (5228802)
1966
38
EFFECT OF HYPERVITAMINOSIS A ON RAT PLASMA LIPIDS. (14308475)
1965
39
CISTERNAL CEREBROSPINAL FLUID PRESSURE DURING DEVELOPMENT OF CHRONIC BOVINE HYPERVITAMINOSIS A. (14344978)
1965
40
EFFECTS OF HYPERVITAMINOSIS A AND D ON SKELETAL METABOLISM. (14165937)
1964
41
HYPERVITAMINOSIS A. REPORT OF A CASE. (14130230)
1964
42
Influence of uterine postion on the response of the mouse embryo to the teratogenic effects of hypervitaminosis-A. (13786639)
1961
43
The teratogenic effects of hypervitaminosis A upon the face and mouth of inbred mice. (14404193)
1960
44
Observations on epiphyseal growth potential following temporary hypervitaminosis A. (13391547)
1956
45
Hypervitaminosis A and avitaminosis C]. (13199433)
1954
46
The activity of ascorbic acid in hypervitaminosis-A in the guinea-pig. (13128868)
1953
47
Hypervitaminosis; a study of an unusual case. (14934528)
1952
48
Hypervitaminosis A; a case report. (14890815)
1952
49
Effect of hypervitaminosis A and hypovitaminosis A on the skeleton of a duck. (14868158)
1951
50
Thyroxine and hypervitaminosis-A. (16747078)
1939

Genetic Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome
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Pathways related to Hypervitaminosis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP26B1, RBP4
29.6CDKN1B, CDKN1A
39.6CDKN1B, CDKN1A
4
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.6CDKN1B, CDKN1A
5
Hide members
9.3CDKN1B, CDKN1A, RBP4
69.0RBP4, CDKN1A, CDKN1B, TTR

Compounds for genes affiliated with Hypervitaminosis a

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hypervitaminosis a according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1purpurin4410.2TTR, RBP4
2retinyl palmitate44 2411.1RBP4, TTR
3lutein4410.1RBP4, TTR
4tocopherol4410.1RBP4, TTR
5cellulose acetate4410.0TTR, RBP4
6mimosine44 1110.9CDKN1B, CDKN1A
7eb 108944 5910.8CDKN1A, CDKN1B
8aphidicolin449.7CDKN1B, CDKN1A
9ciglitazone44 2810.7CDKN1A, CDKN1B
10ns 39844 5910.6CDKN1B, CDKN1A
11indole-3-carbinol449.6CDKN1B, CDKN1A
12retinoid449.6TTR, CDKN1A, RBP4
13resveratrol44 59 11 2412.6TTR, CDKN1B, CDKN1A
14agar449.5TTR, CDKN1B, CDKN1A
15threonine448.6CDKN1A, CDKN1B, TTR, SDS
16serine448.1SDS, TTR, CDKN1B, CDKN1A, RBP4

GO Terms for genes affiliated with Hypervitaminosis a

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16Gene Ontology
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Biological processes related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.9TTR, RBP4
2mitotic cell cycle arrestGO:0718509.7CDKN1B, CDKN1A
3gluconeogenesisGO:0060949.6SDS, RBP4
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN1A, CDKN1B
5negative regulation of phosphorylationGO:0423269.3CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Hypervitaminosis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet