MCID: HYP058
MIFTS: 39

Hypervitaminosis a malady

Categories: Metabolic diseases

Aliases & Classifications for Hypervitaminosis a

Aliases & Descriptions for Hypervitaminosis a:

Name: Hypervitaminosis a 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9972
ICD10 33 E67.0
ICD9CM 35 278.2
MeSH 42 D006986
SNOMED-CT 64 64559002
UMLS 69 C0020579

Summaries for Hypervitaminosis a

MalaCards based summary : Hypervitaminosis a is related to hepatitis and integumentary system benign neoplasm. An important gene associated with Hypervitaminosis a is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are E2F transcription factor network and Association Between Physico-Chemical Features and Toxicity Associated Pathways. The drugs Vitamin A and acetic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related phenotypes are Decreased viability and cardiovascular system

Wikipedia : 71 Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise... more...

Related Diseases for Hypervitaminosis a

Diseases in the Hypervitaminosis D family:

Hypervitaminosis a

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.1
2 integumentary system benign neoplasm 10.1 CDKN1A CDKN1B
3 extraocular retinoblastoma 10.0 CDKN1A CDKN1B
4 intracranial hypertension 9.9
5 hyperostosis 9.9
6 exencephaly 9.8
7 solar retinopathy 9.8 RARS RBP4 TTR
8 thyroiditis 9.8
9 cystic fibrosis 9.8
10 hypoxia 9.7
11 acne 9.7
12 cervicitis 9.7
13 portal hypertension 9.5
14 choroiditis 9.5
15 brain compression 9.5
16 hypervitaminosis d 9.5
17 protein-energy malnutrition 9.5
18 goiter 9.5
19 dysphagia 9.5
20 neuroblastoma 9.5
21 gout 9.5
22 breast cancer 9.5
23 cholestasis 9.5
24 papilledema 9.5
25 hypoprothrombinemia 9.5
26 viral hepatitis 9.5
27 scurvy 9.5
28 alagille syndrome 9.5
29 vaginitis 9.5
30 spondylosis 9.5
31 alopecia 9.5
32 papilloma 9.5
33 hydrocephalus 9.5
34 overnutrition 9.5
35 thrombocytopenia 9.5
36 adenoma 9.5
37 tertiary neurosyphilis 8.8 CDKN1A CDKN1B MGP RARG RARS RBP4

Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to Hypervitaminosis a

Symptoms & Phenotypes for Hypervitaminosis a

GenomeRNAi Phenotypes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 MGP RBP4
2 Decreased viability GR00381-A-2 9.1 MGP RBP4
3 Decreased viability GR00381-A-3 9.1 MGP RBP4

MGI Mouse Phenotypes related to Hypervitaminosis a:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 RBP4 SLCO2A1 CDKN1A CDKN1B MGP RARG
2 homeostasis/metabolism MP:0005376 9.7 CDKN1A CDKN1B MGP RARG RBP4 SLCO2A1
3 renal/urinary system MP:0005367 9.35 CDKN1A CDKN1B MGP RARG SLCO2A1
4 vision/eye MP:0005391 9.02 CDKN1A CDKN1B RARG RBP4 TTR

Drugs & Therapeutics for Hypervitaminosis a

Drugs for Hypervitaminosis a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 11103-57-4, 68-26-8 445354
2
acetic acid Approved, Nutraceutical Phase 1, Phase 2 64-19-7 176
3 Trace Elements Phase 1, Phase 2
4 Vitamins Phase 1, Phase 2
5 Protective Agents Phase 1, Phase 2
6 Retinol palmitate Phase 1, Phase 2
7 Micronutrients Phase 1, Phase 2
8 Antioxidants Phase 1, Phase 2
9
Retinol acetate Phase 1, Phase 2 127-47-9 10245972
10 Adjuvants, Immunologic Phase 1, Phase 2
11 retinol Nutraceutical Phase 1, Phase 2
12 Sunflower Nutraceutical Phase 1, Phase 2
13 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase
1 Novel Isotope Dilution Technique to Assess Vitamin A Status and Hypervitaminosis A Recruiting NCT03000543 Phase 1, Phase 2
2 Total Body Vitamin A Before and After Vitamin A Supplementation in a Community Where Liver is Frequently Eaten Completed NCT02915731

Search NIH Clinical Center for Hypervitaminosis a

Cochrane evidence based reviews: hypervitaminosis a

Genetic Tests for Hypervitaminosis a

Anatomical Context for Hypervitaminosis a

MalaCards organs/tissues related to Hypervitaminosis a:

39
Bone, Liver, Lung, Skin, Thyroid, Testes, Adrenal Gland

Publications for Hypervitaminosis a

Articles related to Hypervitaminosis a:

(show top 50) (show all 350)
id Title Authors Year
1
Hypervitaminosis a causing hypercalcemia in cystic fibrosis. Case report and focused review. ( 25188737 )
2014
2
Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia. ( 25119682 )
2014
3
Hypervitaminosis A-induced hepatic fibrosis in a cat. ( 24563496 )
2014
4
Hypercalcaemia Secondary to Hypervitaminosis A in a Patient with Chronic Renal Failure. ( 25303202 )
2014
5
Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats. ( 23591666 )
2012
6
Hypercalcemia, hypervitaminosis A and 3-epi-25-OH-D3 levels after consumption of an "over the counter" vitamin D remedy. a case report. ( 22426357 )
2012
7
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. ( 22215263 )
2012
8
Hypervitaminosis A in lambs fed milk replacer. ( 22952133 )
2012
9
Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system. ( 23028466 )
2012
10
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. ( 22937283 )
2011
11
Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A. ( 21306609 )
2011
12
Correcting a misrepresentation of hypervitaminosis A attributed to Herbalife product consumption. ( 21315714 )
2011
13
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. ( 19619235 )
2010
14
Orally ingested (13)C(2)-retinol is incorporated into hepatic retinyl esters in a nonhuman primate (Macaca mulatta) model of hypervitaminosis A. ( 20158952 )
2010
15
The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A. ( 19808077 )
2010
16
Hypervitaminosis A inducing intra-hepatic cholestasis--a rare case report. ( 19944093 )
2010
17
Acute hypervitaminosis A in a young lady. ( 20395929 )
2010
18
Hypervitaminosis A altering the lipid profile in a hypercholesterolemic patient. ( 21291816 )
2009
19
Dysphagia and hypervitaminosis A: cervical hyperostosis. ( 19289294 )
2009
20
Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A. ( 19710158 )
2009
21
Hypervitaminosis A in experimental nonhuman primates: evidence, causes, and the road to recovery. ( 19484706 )
2009
22
Hypervitaminosis a in pediatric hematopoietic stem cell patients requiring renal replacement therapy. ( 19033221 )
2008
23
Hypervitaminosis A-induced premature closure of epiphyses (physeal obliteration) in humans and calves (hyena disease): a historical review of the human and veterinary literature. ( 17909784 )
2007
24
Central physeal arrests as a manifestation of hypervitaminosis A. ( 17414024 )
2007
25
Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. ( 16448456 )
2006
26
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. ( 16289060 )
2006
27
Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta Mouse). ( 16054864 )
2005
28
Hypercalcemia caused by iatrogenic hypervitaminosis A. ( 15635357 )
2005
29
Hypervitaminosis A in the cat: a case report and review of the literature. ( 15994105 )
2005
30
Polar hysteria: an expression of hypervitaminosis A. ( 15543093 )
2004
31
Hypervitaminosis A and fractures. ( 12540650 )
2003
32
Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture. ( 14608074 )
2003
33
Hypervitaminosis A and the redistribution of calcium in the neutrophil of chronic renal failure patients on maintenance hemodialysis treatment. ( 12356198 )
2002
34
Infant hypervitaminosis A causes severe anemia and thrombocytopenia: evidence of a retinol-dependent bone marrow cell growth inhibition. ( 11877274 )
2002
35
Subclinical hypervitaminosis A causes fragile bones in rats. ( 12531562 )
2002
36
Hyperostotic polyarthropathy in a rabbit--a suspected case of chronic hypervitaminosis A from a diet of carrots. ( 11702930 )
2001
37
Hypervitaminosis A and bone. ( 10860393 )
2000
38
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. ( 11716591 )
2000
39
Benign intracranial hypertension associated with hypervitaminosis A. ( 9503739 )
1998
40
Alterations in kidney enzyme pattern in acute hypervitaminosis A. ( 9830487 )
1998
41
Local disappearance of epiphyseal growth plates in rats with hypervitaminosis A. ( 9713809 )
1998
42
Mouse palatal width growth rates as an "at risk" factor in the development of cleft palate induced by hypervitaminosis A. ( 9493079 )
1997
43
Hypervitaminosis A as a complication of treatment for neuroblastoma. ( 8599009 )
1996
44
Hypervitaminosis - a. ( 20947982 )
1996
45
Hypervitaminosis A in two hemodialysis patients. ( 7847365 )
1995
46
Effects of hypervitaminosis A on rat fetus esophagus smooth muscle cells. ( 8580885 )
1995
47
Effect of hypervitaminosis A on intestinal digestive & absorptive functions in rat. ( 8063349 )
1994
48
Hypervitaminosis A in a cat. ( 1639706 )
1992
49
Hypervitaminosis A and reproductive disorders in rabbits. ( 1320154 )
1992
50
Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A. ( 1612491 )
1992

Variations for Hypervitaminosis a

Expression for Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for Hypervitaminosis a

GO Terms for Hypervitaminosis a

Cellular components related to Hypervitaminosis a according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 CDKN1A CDKN1B RBP4 TTR

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.49 CDKN1A CDKN1B
2 retinoid metabolic process GO:0001523 9.48 RBP4 TTR
3 response to retinoic acid GO:0032526 9.46 RARG RBP4
4 positive regulation of cell death GO:0010942 9.43 CDKN1A CDKN1B
5 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.4 CDKN1A CDKN1B
6 retinol metabolic process GO:0042572 9.37 RBP4 TTR
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.32 CDKN1A CDKN1B
8 negative regulation of phosphorylation GO:0042326 9.26 CDKN1A CDKN1B
9 mitotic cell cycle arrest GO:0071850 9.16 CDKN1A CDKN1B
10 positive regulation of programmed cell death GO:0043068 8.96 CDKN1A RARG
11 negative regulation of cyclin-dependent protein kinase activity GO:1904030 8.62 CDKN1A CDKN1B

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase inhibitor activity GO:0004860 9.26 CDKN1A CDKN1B
2 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.16 CDKN1A CDKN1B
3 cyclin binding GO:0030332 8.96 CDKN1A CDKN1B
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1A CDKN1B

Sources for Hypervitaminosis a

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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