MCID: HYP058
MIFTS: 35

Hypervitaminosis a malady

Category: Metabolic diseases

Aliases & Classifications for Hypervitaminosis a

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Aliases & Descriptions for Hypervitaminosis a:

Name: Hypervitaminosis a 11 13 48 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:9972
ICD1028 E67.0
SNOMED-CT60 64559002
ICD9CM30 278.2
MeSH37 D006986

Summaries for Hypervitaminosis a

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Wikipedia:69 Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise... more...

MalaCards based summary: Hypervitaminosis a is related to hepatitis and bilateral retinoblastoma. An important gene associated with Hypervitaminosis a is CDKN1B (Cyclin Dependent Kinase Inhibitor 1B), and among its related pathways are Validated targets of C-MYC transcriptional repression and Celecoxib Pathway, Pharmacodynamics. Affiliated tissues include bone, liver and lung, and related mouse phenotype vision/eye.

Related Diseases for Hypervitaminosis a

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Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Symptoms for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Total Body Vitamin A Before and After Vitamin A Supplementation in a Community Where Liver is Frequently EatenCompletedNCT02915731

Search NIH Clinical Center for Hypervitaminosis a


Cochrane evidence based reviews: hypervitaminosis a

Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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MalaCards organs/tissues related to Hypervitaminosis a:

34
Bone, Liver, Lung, Skin, Thyroid, Testes, Adrenal gland

Animal Models for Hypervitaminosis a or affiliated genes

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MGI Mouse Phenotypes related to Hypervitaminosis a:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4CDKN1A, CDKN1B, RARG, RBP4, TTR

Publications for Hypervitaminosis a

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Articles related to Hypervitaminosis a:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Hypercalcaemia Secondary to Hypervitaminosis A in a Patient with Chronic Renal Failure. (25303202)
2014
2
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
3
Correcting a misrepresentation of hypervitaminosis A attributed to Herbalife product consumption. (21315714)
2011
4
Orally ingested (13)C(2)-retinol is incorporated into hepatic retinyl esters in a nonhuman primate (Macaca mulatta) model of hypervitaminosis A. (20158952)
2010
5
Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A. (19710158)
2009
6
Susceptibility to teratogenicity of hypervitaminosis-A in X-monosomy mice. (1288763)
1992
7
Hypervitaminosis A and glycerol lysis time (GLT). (3710713)
1986
8
Hypervitaminosis A in a child from megadosing. (3988928)
1985
9
Pibloktoq (hysteria) and Inuit nutrition: possible implication of hypervitaminosis A. (4049004)
1985
10
Ingestion of shark liver associated with pseudotumor cerebri due to acute hypervitaminosis A. (6707663)
1984
11
Clinical manifestations of hypervitaminosis A in human gingiva. A case report. (6592319)
1984
12
Oxygen consumption and survival prediction in neonatal rats exposed to prenatal hypervitaminosis A. (6417812)
1983
13
Protein-calorie deficiency and vitamin indiscretion in an atopic child who developed hypervitaminosis A. (6799241)
1982
14
Morphometric study of malformations induced by hypervitaminosis A on rat fetus Meckel cartilage, maxillary bone and mandible. (6762114)
1982
15
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
16
Effect of hypervitaminosis A on the Harderian gland in rats. A morphologic and morphometric study. (357318)
1978
17
Tissue catalysis of lipid peroxidation in hypervitaminosis A. (721121)
1978
18
Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. (20486)
1977
19
Mucous metaplasia of the hamster cheek pouch epithelium under hypervitaminosis A. (1157887)
1975
20
Hypervitaminosis A in the dog. (1190603)
1975
21
Ultrastructural changes in livers of two patients with hypervitaminosis A. (4416771)
1974
22
Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites. (4843409)
1974
23
Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A. (4664235)
1972
24
Pseudotumour cerebri due to hypervitaminosis A (a case report). (4662752)
1972
25
Hypervitaminosis A dysmelia in rats. (4332598)
1971
26
Rates of formation and absorption of cerebrospinal fluid in mild chronic bovine hypervitaminosis A. (5479487)
1970
27
Hepatic injury in chronic hypervitaminosis A. (5410560)
1970
28
Effects of ovariectomy and hypervitaminosis A on lysosomes of the rat conceptus. (4312014)
1969
29
Histology of onset of skin changes in hypervitaminosis A in chickens. (5784665)
1969
30
Some effects of hypervitaminosis A on metastasis of spontaneous breast cancer in mice. (5353238)
1969
31
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
32
ALTERATIONS IN THE LIPIDS OF BONE CAUSED BY HYPERVITAMINOSIS A AND D. (14343141)
1965
33
EFFECT OF HYPERVITAMINOSIS A ON RAT PLASMA LIPIDS. (14308475)
1965
34
Hypervitaminosis A and hyperostosis of the cat. (5893701)
1965
35
CONNECTIVE TISSUE IX: EFFECTS OF HYPERVITAMINOSIS A UPON CONNECTIVE TISSUE CHEMISTRY. (14155781)
1964
36
Observations on the effect of experimental endocrine procedures on the teratogenic action of hypervitaminosis A in the rat. (13880340)
1961
37
Analysis of an anomalous oculodentofacial pattern in newborn rats produced by maternal hypervitaminosis A. (13631147)
1959
38
Late effects of hypervitaminosis A in the rat; disturbance and retardation in the normal growth of offspring. (13570808)
1958
39
Hypervitaminosis A: its broadening spectrum. (13559160)
1958
40
Hypervitaminosis A. (13425777)
1957
41
Hypervitaminosis A. (13425775)
1957
42
Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats. (13328832)
1956
43
Chronic hypervitaminosis A; report of a probable case in a man. (13265422)
1955
44
The activity of ascorbic acid in hypervitaminosis-A in the guinea-pig. (13128868)
1953
45
Hypervitaminosis A and the skeleton of growing chicks. (14932587)
1952
46
Hypervitaminosis A and ascorbic acid. (14894250)
1951
47
Hypervitaminosis A; report of a case. (14774092)
1950
48
Effects of hypervitaminosis A on foetal mouse bones cultivated in vitro; preliminary communication. (15434451)
1950
49
Hypervitaminosis A and scurvy. (18229143)
1949
50
Hypervitaminosis A; a case report. (18872296)
1948

Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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GO Terms for genes affiliated with Hypervitaminosis a

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Cellular components related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.4CDKN1B, RBP4, SET, TTR

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:007185010.2CDKN1A, CDKN1B
2negative regulation of phosphorylationGO:004232610.2CDKN1A, CDKN1B
3negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.2CDKN1A, CDKN1B
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.1CDKN1A, CDKN1B
5positive regulation of programmed cell deathGO:004306810.0CDKN1A, RARG
6regulation of cyclin-dependent protein serine/threonine kinase activityGO:00000799.8CDKN1A, CDKN1B
7retinoid metabolic processGO:00015239.8RBP4, TTR
8retinol metabolic processGO:00425729.6RBP4, TTR
9response to retinoic acidGO:00325269.5RARG, RBP4
10positive regulation of cell deathGO:00109429.5CDKN1A, CDKN1B

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.8CDKN1A, CDKN1B

Sources for Hypervitaminosis a

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet