MCID: HYP058
MIFTS: 41

Hypervitaminosis a malady

Metabolic diseases category

Aliases & Classifications for Hypervitaminosis a

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Hypervitaminosis a, Aliases & Descriptions:

Name: Hypervitaminosis a 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:9972
MeSH33 D006986
SNOMED-CT55 64559002
ICD9CM27 278.2
ICD1025 E67.0

Summaries for Hypervitaminosis a

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Wikipedia:63 Hypervitaminosis A refers to any number of a large amount of toxic effects from ingesting too much... more...

MalaCards based summary: Hypervitaminosis a is related to protein-energy malnutrition and papilloma. An important gene associated with Hypervitaminosis a is RBP4 (retinol binding protein 4, plasma), and among its related pathways are the visual cycle I (vertebrates) and Visual Cycle in Retinal Rods. The compounds n-(4-hydroxyphenyl)retinamide and purpurin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related mouse phenotypes are muscle and no phenotypic analysis.

Related Diseases for Hypervitaminosis a

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Graphical network of the top 20 diseases related to Hypervitaminosis a:



Diseases related to hypervitaminosis a

Symptoms for Hypervitaminosis a

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Drugs & Therapeutics for Hypervitaminosis a

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Drug clinical trials:

Search ClinicalTrials for Hypervitaminosis a

Search NIH Clinical Center for Hypervitaminosis a

Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

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MalaCards organs/tissues related to Hypervitaminosis a:

31
Bone, Liver, Lung, Thyroid, Skin, Testes, Adrenal gland, Bone marrow, Eye, Brain, Heart, Smooth muscle, Kidney, Pancreas, Salivary gland, Breast, Tongue, Pituitary, Neutrophil

Animal Models for Hypervitaminosis a or affiliated genes

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MGI Mouse Phenotypes related to Hypervitaminosis a:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CDKN1B, CDKN1A, RBP4
2MP:00030128.2CDKN1B, CDKN1A, TTR
3MP:00053918.0CDKN1B, CDKN1A, RBP4, TTR
4MP:00053767.9TTR, RBP4, CDKN1A, CDKN1B

Publications for Hypervitaminosis a

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Articles related to Hypervitaminosis a:

(show top 50)    (show all 347)
idTitleAuthorsYear
1
Hypervitaminosis a causing hypercalcemia in cystic fibrosis. Case report and focused review. (25188737)
2014
2
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
3
Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism. (22937283)
2011
4
Acute hypervitaminosis A in a young lady. (20395929)
2010
5
Subclinical hypervitaminosis A in rat: measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. (16289060)
2006
6
Back-scattered electron imaging of a non-vertebral case of hypervitaminosis A in a cat. (11716591)
2000
7
Assessment of risk factors for carotenodermia and cutaneous signs of hypervitaminosis A in college-aged populations. (1764358)
1991
8
Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats. (3147800)
1988
9
Hepatic and dermatologic manifestations of chronic hypervitaminosis A in adults. Report of two cases. (2937294)
1986
10
Hypervitaminosis A in a child from megadosing. (3988928)
1985
11
Ingestion of shark liver associated with pseudotumor cerebri due to acute hypervitaminosis A. (6707663)
1984
12
Discordant hepatic uptake between Tc-99m sulfur colloid and Tc-99m DISIDA in hypervitaminosis A. (6539369)
1984
13
Clinical manifestations of hypervitaminosis A in human gingiva. A case report. (6592319)
1984
14
Protein-calorie deficiency and vitamin indiscretion in an atopic child who developed hypervitaminosis A. (6799241)
1982
15
Morphometric study of malformations induced by hypervitaminosis A on rat fetus Meckel cartilage, maxillary bone and mandible. (6762114)
1982
16
Malformations of the eye resulting from maternal hypervitaminosis A during gestation in the rat. (6800208)
1981
17
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
18
Morphometric study of the reversibility of testicle alterations in rats submitted to hypervitaminosis A. (738845)
1978
19
Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. (20486)
1977
20
Morphologic alterations associated with decreased cerebrospinal fluid pressure in chronic bovine hypervitaminosis A. (1111381)
1975
21
Ultrastructural changes in livers of two patients with hypervitaminosis A. (4416771)
1974
22
Effect of hypervitaminosis A on immunocompetence in rats. (4549758)
1974
23
A light and electron microscopic study of the lymphomyeloid complex in hypervitaminosis A. (5075296)
1972
24
Lack of hypertrophy of the adrenal in exencephalic fetal rats subjected to hypervitaminosis A and then to maternal adrenalectomy. (4324682)
1971
25
Hypervitaminosis A dysmelia in rats. (4332598)
1971
26
Rates of formation and absorption of cerebrospinal fluid in mild chronic bovine hypervitaminosis A. (5479487)
1970
27
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
28
Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity. (5485475)
1970
29
Hepatic injury in chronic hypervitaminosis A. (5410560)
1970
30
Effects of ovariectomy and hypervitaminosis A on lysosomes of the rat conceptus. (4312014)
1969
31
Effect of hypervitaminosis A on intestinal lipids of rats. (6048389)
1967
32
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
33
Bone strength and calcium retention of rats in hypervitaminosis-A. (5178796)
1966
34
MALFORMATIONS OF THE MOUSE FETUS CAUSED BY HYPERVITAMINOSIS-A OF THE MOTHER DURING PREGNANCY. (14280198)
1965
35
ALTERATIONS IN THE LIPIDS OF BONE CAUSED BY HYPERVITAMINOSIS A AND D. (14343141)
1965
36
Carbohydrate metabolism in hypervitaminosis A. (14436609)
1959
37
Analysis of an anomalous oculodentofacial pattern in newborn rats produced by maternal hypervitaminosis A. (13631147)
1959
38
Late effects of hypervitaminosis A in the rat; disturbance and retardation in the normal growth of offspring. (13570808)
1958
39
Hypervitaminosis A; toxic reaction. (13508636)
1958
40
Hypervitaminosis A. (13425777)
1957
41
Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats. (13328832)
1956
42
Chronic hypervitaminosis A; report of a probable case in a man. (13265422)
1955
43
The biochemistry and pathology of hypervitaminosis A. (14374254)
1954
44
The activity of ascorbic acid in hypervitaminosis-A in the guinea-pig. (13128868)
1953
45
Hypervitaminosis; a study of an unusual case. (14934528)
1952
46
Hypervitaminosis A; a case report. (14890815)
1952
47
Effect of hypervitaminosis A on hepatic ascorbic acid in the rat. (14924655)
1952
48
Hypervitaminosis A with infantile cortical hyperostosis. (14850258)
1951
49
Hypervitaminosis A; report of a case. (14774092)
1950
50
Hypervitaminosis A; a case report. (18872296)
1948

Variations for Hypervitaminosis a

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Expression for genes affiliated with Hypervitaminosis a

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Search GEO for disease gene expression data for Hypervitaminosis a.

Pathways for genes affiliated with Hypervitaminosis a

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Pathways related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TTR, RBP4
29.3TTR, RBP4
3
Show member pathways
9.3TTR, RBP4
4
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.1CDKN1B, CDKN1A
5
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.1CDKN1A, CDKN1B
6
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.1CDKN1A, CDKN1B
79.1CDKN1B, CDKN1A
8
Show member pathways
Cell cycle36
9.1CDKN1B, CDKN1A
9
Show member pathways
9.1CDKN1A, CDKN1B
109.1CDKN1B, CDKN1A
11
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.1CDKN1A, CDKN1B
129.1CDKN1A, CDKN1B
139.1CDKN1B, CDKN1A
14
Show member pathways
9.1CDKN1B, CDKN1A
159.1CDKN1B, CDKN1A
16
Show member pathways
Signaling Pathways in Glioblastoma36
9.1CDKN1B, CDKN1A
179.1CDKN1B, CDKN1A
18
Show member pathways
9.1CDKN1B, CDKN1A
199.1CDKN1A, CDKN1B
20
Show member pathways
9.1CDKN1B, CDKN1A
219.1CDKN1B, CDKN1A
229.1CDKN1B, CDKN1A
239.1CDKN1B, CDKN1A
249.1CDKN1A, CDKN1B
25
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.1CDKN1B, CDKN1A
26
Show member pathways
AhR pathway36
9.1CDKN1B, CDKN1A
279.1CDKN1A, CDKN1B
28
Show member pathways
DNA damage response36
9.1CDKN1B, CDKN1A
29
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.1CDKN1A, CDKN1B
309.1CDKN1B, CDKN1A
31
Show member pathways
9.1CDKN1A, CDKN1B
32
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.1CDKN1B, CDKN1A
339.1CDKN1B, CDKN1A
349.1CDKN1B, CDKN1A
359.1CDKN1A, CDKN1B
36
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.6CDKN1B, CDKN1A, RBP4
378.0TTR, RBP4, CDKN1A, CDKN1B
38
Show member pathways
8.0CDKN1B, CDKN1A, RBP4, TTR

Compounds for genes affiliated with Hypervitaminosis a

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Compounds related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1n-(4-hydroxyphenyl)retinamide439.8CDKN1A, RBP4
2purpurin439.8RBP4, TTR
3retinyl palmitate43 2410.8RBP4, TTR
4lutein439.8RBP4, TTR
5tocopherol439.8RBP4, TTR
6cellulose acetate439.7RBP4, TTR
7phosphorus439.7TTR, RBP4
8isoleucine439.7RBP4, TTR
9betacarotene439.7RBP4, TTR
10triiodothyronine439.7RBP4, TTR
11uric acid43 2410.6RBP4, TTR
12vitamin-e439.6RBP4, TTR
13mimosine43 1210.6CDKN1A, CDKN1B
14eb 108943 5910.5CDKN1A, CDKN1B
15phorbol439.5CDKN1A, RBP4
16aphidicolin439.5CDKN1B, CDKN1A
17ciglitazone43 2810.5CDKN1B, CDKN1A
18alpha tocopherol439.5RBP4, TTR
19ns 39843 5910.5CDKN1B, CDKN1A
20indole-3-carbinol439.5CDKN1B, CDKN1A
21leptomycin b43 5910.5CDKN1A, CDKN1B
22flavopiridol43 1210.5CDKN1B, CDKN1A
23celecoxib43 59 28 49 24 1214.5CDKN1B, CDKN1A
24bortezomib43 49 1211.5CDKN1B, CDKN1A
25gefitinib43 49 1211.4CDKN1A, CDKN1B
26gemcitabine43 49 1211.4CDKN1B, CDKN1A
27lactacystin439.4CDKN1B, CDKN1A
28lovastatin43 49 59 28 1213.4CDKN1A, CDKN1B
29urea43 24 1211.3RBP4, TTR
30rosiglitazone28 43 49 24 1213.3CDKN1A, RBP4
31ornithine43 2410.3CDKN1B, RBP4
32retinoid439.3CDKN1A, RBP4, TTR
33cytarabine43 49 1211.2CDKN1B, CDKN1A
34progesterone43 28 59 24 1213.0CDKN1B, CDKN1A, RBP4
35resveratrol43 59 24 1212.0CDKN1B, CDKN1A, TTR
36agar439.0TTR, CDKN1A, CDKN1B
37paraffin438.9TTR, CDKN1A, CDKN1B
38genistein43 28 59 2 24 1213.9CDKN1B, CDKN1A, TTR
39leucine438.9TTR, RBP4, CDKN1B
40testosterone43 59 24 1211.9CDKN1B, RBP4, TTR
41cholesterol43 28 24 1211.9TTR, RBP4, CDKN1B
42dexamethasone43 49 28 1211.9TTR, RBP4, CDKN1B
43troglitazone43 28 59 1211.8CDKN1B, CDKN1A
44threonine438.8CDKN1B, CDKN1A, TTR
45alanine438.8TTR, RBP4, CDKN1B
46oxygen43 249.8RBP4, CDKN1A, CDKN1B
47glucose438.5TTR, RBP4, CDKN1B
48estrogen438.4TTR, RBP4, CDKN1A, CDKN1B
49retinoic acid43 249.4CDKN1B, CDKN1A, RBP4, TTR
50serine438.4CDKN1B, CDKN1A, RBP4, TTR

GO Terms for genes affiliated with Hypervitaminosis a

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Cellular components related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.5CDKN1B, RBP4, TTR

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:00425729.6RBP4, TTR
2retinoid metabolic processGO:00015239.6RBP4, TTR
3phototransduction, visible lightGO:00076039.5TTR, RBP4
4mitotic cell cycle arrestGO:00718509.4CDKN1B, CDKN1A
5negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.4CDKN1B, CDKN1A
6negative regulation of phosphorylationGO:00423269.4CDKN1A, CDKN1B
7regulation of cyclin-dependent protein serine/threonine kinase activityGO:00000799.4CDKN1B, CDKN1A
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.3CDKN1B, CDKN1A
9negative regulation of cell growthGO:00303089.3CDKN1B, CDKN1A
10cell cycle arrestGO:00070509.2CDKN1B, CDKN1A
11phosphatidylinositol-mediated signalingGO:00480159.2CDKN1B, CDKN1A
12G1/S transition of mitotic cell cycleGO:00000829.1CDKN1A, CDKN1B
13epidermal growth factor receptor signaling pathwayGO:00071739.1CDKN1B, CDKN1A
14fibroblast growth factor receptor signaling pathwayGO:00085439.0CDKN1B, CDKN1A
15Fc-epsilon receptor signaling pathwayGO:00380958.8CDKN1B, CDKN1A

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.1CDKN1B, CDKN1A
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048618.8CDKN1B, CDKN1A

Products for genes affiliated with Hypervitaminosis a

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Sources for Hypervitaminosis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet