MCID: HYP057
MIFTS: 38

Hypervitaminosis D malady

Categories: Metabolic diseases

Aliases & Classifications for Hypervitaminosis D

Aliases & Descriptions for Hypervitaminosis D:

Name: Hypervitaminosis D 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9971
ICD10 33 E67.3
ICD9CM 35 278.4
SNOMED-CT 64 190969000 27712000
UMLS 69 C1442839

Summaries for Hypervitaminosis D

MalaCards based summary : Hypervitaminosis D is related to calcinosis and y chromosome detection. An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Negative regulation of FGFR1 signaling and Signaling by FGFR2. The drugs Cholecalciferol and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Hypervitaminosis D

Diseases in the Hypervitaminosis D family:

Hypervitaminosis a

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 calcinosis 29.5 FGF23 KL PTH
2 y chromosome detection 10.1 CYP27B1 PTH
3 opthalmoplegia mental retardation lingua scrotalis 10.1 FGF23 PTH
4 joubert syndrome 9 10.1 FGF23 PTH
5 prediabetes syndrome 10.1 FGF23 PTH
6 toenail dystrophy, isolated 10.1 FGF23 PTH
7 tinea unguium 10.1 FGF23 PTH
8 opioid abuse 10.1 FGF23 PTH
9 osteochondrodysplasia 10.1 KL PTH
10 opportunistic bacterial infectious disease 10.0 FGF23 PTH
11 oligospermia 10.0 FGF23 KL
12 prostate cancer, hereditary, x-linked 2 10.0 CYP27B1 FGF23
13 pre-eclampsia 10.0 FGF23 PTH
14 parathyroid gland disease 10.0 FGF23 PTH
15 peroxisome biogenesis disorder 2b 9.9 FGF23 GALNT3
16 pes anserinus tendinitis or bursitis 9.9 CYP27B1 FGF23 PTH
17 ischemic bone disease 9.9 CYP27B1 FGF23 PTH
18 subserous uterine fibroid 9.9 CYP27B1 FGF23 PTH
19 chronic myocardial ischemia 9.9 CYP27B1 FGF23 PTH
20 parathyroid carcinoma 9.9 FGF23 PTH
21 post-traumatic stress disorder 9.8 FGF23 GALNT3
22 arteriosclerosis 9.8
23 diabetes insipidus 9.8
24 atherosclerosis 9.8
25 rickets 9.8
26 saddan 9.8 FGF23 GALNT3
27 donnai-barrow syndrome 9.7 FGF23 GALNT3 KL
28 feigenbaum bergeron richardson syndrome 9.7 FGF23 GALNT3 KL
29 childhood absence epilepsy 9.7 FGF23 GALNT3 KL
30 coffin-lowry syndrome 9.7 CYP27B1 FGF23 KL PTH
31 allergic urticaria 9.7 CYP27B1 FGF23 KL PTH
32 carnitine deficiency, systemic primary 9.7 CYP27B1 FGF23 KL PTH
33 pulmonary tuberculosis 9.7
34 tuberculosis 9.7
35 pneumonia 9.7
36 rheumatoid arthritis 9.7
37 periodontitis 9.7
38 osteoporosis 9.7
39 neurofibromatosis 9.7
40 cystic fibrosis 9.7
41 alagille syndrome 9.7
42 hypervitaminosis a 9.7
43 arthritis 9.7
44 dentin dysplasia 9.7
45 mannosidosis 9.7
46 fanconi syndrome 9.7
47 hyperparathyroidism 9.7
48 weill-marchesani syndrome 9.6 FGF23 GALNT3 KL PTH
49 indian tick typhus 9.6 FGF23 GALNT3 KL PTH
50 gastric antral vascular ectasia 9.4 CYP27B1 FGF23 GALNT3 KL PTH

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D

Symptoms & Phenotypes for Hypervitaminosis D

MGI Mouse Phenotypes related to Hypervitaminosis D:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CYP27B1 FGF23 GALNT3 KL PTH TRPV5
2 cardiovascular system MP:0005385 9.89 CYP27B1 FGF23 GALNT3 KL PTH
3 hematopoietic system MP:0005397 9.88 CYP27B1 FGF23 GALNT3 KL PTH TRPV5
4 endocrine/exocrine gland MP:0005379 9.85 PTH CYP27B1 FGF23 GALNT3 KL
5 homeostasis/metabolism MP:0005376 9.85 CYP27B1 FGF23 GALNT3 KL PTH TRPV5
6 immune system MP:0005387 9.8 CYP27B1 FGF23 GALNT3 KL PTH TRPV5
7 digestive/alimentary MP:0005381 9.78 FGF23 GALNT3 KL TRPV5
8 integument MP:0010771 9.56 CYP27B1 FGF23 GALNT3 KL
9 limbs/digits/tail MP:0005371 9.55 KL PTH CYP27B1 FGF23 GALNT3
10 renal/urinary system MP:0005367 9.35 CYP27B1 FGF23 GALNT3 KL TRPV5
11 skeleton MP:0005390 9.1 CYP27B1 FGF23 GALNT3 KL PTH TRPV5

Drugs & Therapeutics for Hypervitaminosis D

Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
2
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
3 vitamin d Phase 4,Phase 3,Phase 2,Phase 1
4 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
5 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1
6 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
7 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
8 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Hydroxycholecalciferols Phase 4
10 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
11 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 11103-57-4, 68-26-8 445354
13
acetic acid Approved, Nutraceutical Phase 1, Phase 2 64-19-7 176
14 Hepcidins Phase 2
15 Anti-Infective Agents Phase 2
16 Pharmaceutical Solutions Phase 2
17
Retinol acetate Phase 1, Phase 2 127-47-9 10245972
18 Adjuvants, Immunologic Phase 1, Phase 2
19 Protective Agents Phase 1, Phase 2
20 Retinol palmitate Phase 1, Phase 2
21 Antioxidants Phase 1, Phase 2
22 retinol Nutraceutical Phase 1, Phase 2
23 Sunflower Nutraceutical Phase 1, Phase 2
24 Calcium, Dietary
25 Olive Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4
2 Randomized Study of Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease Active, not recruiting NCT01909115 Phase 3
3 Vitamin D as a Modifier of Serum Hepcidin in Children With Chronic Kidney Disease Unknown status NCT01532349 Phase 2
4 Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Completed NCT01838447 Phase 2
5 Novel Isotope Dilution Technique to Assess Vitamin A Status and Hypervitaminosis A Recruiting NCT03000543 Phase 1, Phase 2
6 Vitamin D and Severe Asthma Exacerbations Completed NCT01921894 Phase 1
7 Pilot Trial to Evaluate the Effect of Vitamin D on Melanocyte Biomarkers Completed NCT01477463
8 Efficacy of Vitamin D Therapy on Glucose Homeostasis in Obese Adolescents Completed NCT02414529
9 Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women Active, not recruiting NCT02553044
10 Vitamin D Supplements on Markers for Cardiovascular Disease and Diabetes: an Individual Participant Data Meta-analysis Active, not recruiting NCT02551835

Search NIH Clinical Center for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

Anatomical Context for Hypervitaminosis D

MalaCards organs/tissues related to Hypervitaminosis D:

39
Bone, Kidney, Smooth Muscle, Placenta

Publications for Hypervitaminosis D

Articles related to Hypervitaminosis D:

(show top 50) (show all 115)
id Title Authors Year
1
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. ( 28063517 )
2017
2
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. ( 26897163 )
2016
3
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. ( 26995293 )
2016
4
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. ( 25831571 )
2015
5
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. ( 26557587 )
2015
6
Reversible vascular calcifications associated with hypervitaminosis D. ( 26318020 )
2015
7
Hypervitaminosis-D, an uncommon reality! ( 25906526 )
2014
8
Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report. ( 24571630 )
2014
9
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. ( 25281651 )
2014
10
Tanning beds and hypervitaminosis D: a case report. ( 24887628 )
2014
11
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. ( 23756934 )
2013
12
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. ( 23396467 )
2013
13
Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. ( 23895994 )
2013
14
Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment. ( 25149241 )
2013
15
Hypervitaminosis D in guinea pigs with I+-mannosidosis. ( 23582422 )
2013
16
Serum levels of 3-epi-25-OH-D3 during hypervitaminosis D in clinical practice. ( 23038681 )
2012
17
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. ( 23087723 )
2012
18
Hypervitaminosis D associated with a vitamin D dispensing error. ( 21917555 )
2011
19
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. ( 22461833 )
2011
20
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. ( 19619235 )
2010
21
Neurofibromatosis, pathological fracture and hypervitaminosis-D. ( 21048240 )
2010
22
Hypercalcemia due to hypervitaminosis D: report of seven patients. ( 19339514 )
2009
23
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. ( 16699077 )
2006
24
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. ( 16731043 )
2006
25
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. ( 16148038 )
2005
26
Risk of hypervitaminosis D from prolonged feeding of high vitamin D premature infant formula. ( 15310310 )
2004
27
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. ( 12002522 )
2002
28
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. ( 10887751 )
2000
29
Hypercalcemia and hypervitaminosis D in two lambs. ( 10754674 )
2000
30
Dental changes in hypervitaminosis D. ( 9574950 )
1998
31
Hypervitaminosis D: Report on three patients. ( 17341976 )
1998
32
[Hypervitaminosis D in institutionalized elderly in Buenos Aires]. ( 9435366 )
1997
33
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. ( 7733425 )
1995
34
Hypervitaminosis D after prolonged feeding with a premature formula. ( 8233752 )
1993
35
Hypervitaminosis D associated with drinking milk. ( 1313547 )
1992
36
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. ( 2109995 )
1990
37
Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. ( 2163637 )
1990
38
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. ( 3207390 )
1988
39
Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. ( 2820185 )
1987
40
Severe depressive illness in the context of hypervitaminosis D. ( 3664111 )
1987
41
The osteodystrophy of hypervitaminosis D: a metabolic study. ( 3498181 )
1986
42
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. ( 6091851 )
1984
43
Effect of alkali on metastatic calcification produced by hypervitaminosis D. ( 6098694 )
1984
44
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. ( 6837312 )
1983
45
Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D. ( 6246506 )
1980
46
Effect of hypervitaminosis D on skeletal plutonium levels in mice. ( 7429853 )
1980
47
Deafness due to hypervitaminosis D. ( 87663 )
1979
48
A method for studying plasma transport of vitamin D applicable to hypervitaminosis D. ( 761406 )
1979
49
Hypervitaminosis D in sheep. An experimental study. ( 217259 )
1978
50
25-hydroxy-vitamin D levels in a patient with hypervitaminosis D. ( 672143 )
1978

Variations for Hypervitaminosis D

Expression for Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for Hypervitaminosis D

GO Terms for Hypervitaminosis D

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-mediated signaling GO:0048015 9.52 FGF23 KL
2 phosphatidylinositol phosphorylation GO:0046854 9.51 FGF23 KL
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.5 FGF23 GALNT3 KL
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.49 FGF23 KL
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.48 FGF23 KL
6 positive regulation of bone mineralization GO:0030501 9.46 KL PTH
7 response to vitamin D GO:0033280 9.43 CYP27B1 PTH
8 regulation of bone mineralization GO:0030500 9.4 CYP27B1 FGF23
9 vitamin D metabolic process GO:0042359 9.37 CYP27B1 FGF23
10 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.26 FGF23 KL
11 vitamin D catabolic process GO:0042369 9.16 CYP27B1 FGF23
12 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.96 CYP27B1 FGF23
13 calcium ion homeostasis GO:0055074 8.8 CYP27B1 KL TRPV5

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.32 FGF23 KL
2 hormone activity GO:0005179 9.26 KL PTH
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF23 KL
4 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF23 KL
5 fibroblast growth factor receptor binding GO:0005104 8.62 FGF23 KL

Sources for Hypervitaminosis D

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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