MCID: HYP057
MIFTS: 41

Hypervitaminosis D malady

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Summaries for Hypervitaminosis D

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33MalaCards
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MalaCards: Hypervitaminosis D is related to hypercalcemia and rickets. An important gene associated with Hypervitaminosis D is PTH (parathyroid hormone), and among its related pathways are Vitamin D synthesis and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds amg 9810 and 5-iodoresiniferatoxin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Hypervitaminosis D

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

hypervitaminosis d 8 10 62


External Ids:

Disease Ontology8 DOID:9971
ICD9CM27 278.4
SNOMED-CT58 27712000, 190969000
ICD1025 E67.3

Related Diseases for Hypervitaminosis D

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17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

hypervitaminosis d

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.6FGF23, PTH, CYP27B1
2rickets30.4PTH, CYP27B1
3calcinosis30.3FGF23, PTH, KL
4hyperparathyroidism30.0FGF23, PTH, KL, CYP27B1
5osteoporosis30.0FGF23, KL, PTH, CYP27B1
6diabetes insipidus10.3
7nephrogenic diabetes insipidus10.3
8arteriosclerosis10.3
9atherosclerosis10.3
10neurofibromatosis10.1
11cystic fibrosis10.1
12fanconi syndrome10.1
13alagille syndrome10.1
14hypervitaminosis a10.1
15dentin dysplasia10.1
16pseudotumor cerebri10.1
17arthritis10.1
18osteosclerosis10.1
19periodontitis10.1
20pneumonia10.1
21rheumatoid arthritis10.1
22osteoporosis, postmenopausal10.0CYP27B1, PTH
23renal osteodystrophy10.0FGF23, PTH
24tumoral calcinosis, hyperphosphatemic10.0KL, FGF23
25hyperphosphatemic familial tumoral calcinosis10.0KL, FGF23
26hypoparathyroidism10.0PTH, FGF23
27pulmonary emphysema10.0FGF23, KL
28nephrolithiasis10.0FGF23, PTH
29x-linked hypophosphatemia10.0FGF23, CYP27B1
30hyperthyroidism10.0PTH, FGF23
31primary hyperoxaluria10.0PTH, FGF23
32hyperphosphatemia10.0FGF23, PTH, KL
33primary hyperparathyroidism10.0CYP27B1, PTH, FGF23
34secondary hyperparathyroidism of renal origin10.0PTH, FGF23, CYP27B1
35graves' disease9.9CYP27B1, FGF23
36secondary syphilis9.9PTH, CYP27B1, FGF23
37chronic kidney failure9.9FGF23, PTH, CYP27B1
38hypophosphatemia9.9FGF23, PTH, CYP27B1, KL
39osteomalacia9.9FGF23, KL, PTH, CYP27B1

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to hypervitaminosis d

Symptoms for Hypervitaminosis D

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Drugs & Therapeutics for Hypervitaminosis D

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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33MalaCards
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MalaCards organs/tissues related to Hypervitaminosis D:

33
Bone, Kidney, Smooth muscle, Placenta

Animal Models for Hypervitaminosis D or affiliated genes

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37MGI
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Publications for Hypervitaminosis D

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52PubMed
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Articles related to Hypervitaminosis D:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. (23756934)
2013
2
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. (23396467)
2013
3
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
4
Hypervitaminosis D associated with a vitamin D dispensing error. (21917555)
2011
5
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. (22461833)
2011
6
Neurofibromatosis, pathological fracture and hypervitaminosis-D. (21048240)
2010
7
Hypercalcemia due to hypervitaminosis D: report of seven patients. (19339514)
2009
8
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. (16699077)
2006
9
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. (12002522)
2002
10
Hypervitaminosis D: Report on three patients. (17341976)
1998
11
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. (7733425)
1995
12
Hypervitaminosis D after prolonged feeding with a premature formula. (8233752)
1993
13
Hypervitaminosis D associated with drinking milk. (1313547)
1992
14
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. (2109995)
1990
15
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. (3207390)
1988
16
The osteodystrophy of hypervitaminosis D: a metabolic study. (3498181)
1986
17
Effect of alkali on metastatic calcification produced by hypervitaminosis D. (6098694)
1984
18
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. (6091851)
1984
19
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. (6837312)
1983
20
Effect of hypervitaminosis D on skeletal plutonium levels in mice. (7429853)
1980
21
Ultrastructure of cardiovascular lesions induced by hypervitaminosis D and its withdrawal. (224365)
1978
22
Hypervitaminosis D in sheep. An experimental study. (217259)
1978
23
Hypervitaminosis D in rabbits. (1253099)
1976
24
Bone pathology in hypervitaminosis D an experimental study in young pigs. (182436)
1976
25
Letter: Multiple factors in the hyperlipidaemia of hypervitaminosis D. (1191987)
1975
26
Nephropathy after acute hypervitaminosis-D (an experimental study). (4791939)
1973
27
Metabolic effect of pyridinolcarbamate on the vascular wall of rats with hypervitaminosis D. (4262650)
1972
28
Microradiographic evaluation of bone from cows with experimental hypervitaminosis D, diet-induced hypocalcemia, and naturally occurring parturient paresis. (5050206)
1972
29
Effects of hypervitaminosis D on bones and teeth of rats. (4261660)
1971
30
Effect of hypervitaminosis D upon the phospholipids of metaphyseal and diaphyseal bone. (5299638)
1966
31
The pathology of hypervitaminosis D in cattle. (5957331)
1966
32
Hypervitaminosis D in green iguanas. (22413201)
1966
33
Kidney function and structure in experimental hyperparathyroidism and hypervitaminosis D. (13890267)
1962
34
Hypervitaminosis D with osteosclerosis. (13722405)
1961
35
Response of hemoglobin and cellular elements of blood after hypervitaminosis D in monkeys. (13769311)
1960
36
Experimental arteriosclerosis due to hypervitaminosis D. (13712151)
1960
37
The effect of cortisone in experimental hypervitaminosis D. (13562007)
1958
38
An experimental histologic study of hypervitaminosis D. (13533519)
1958
39
Hypervitaminosis D in monkeys; a clinical and pathologic study. (13498130)
1958
40
Experimental hypervitaminosis D: hypercalcemia, hypermucoproteinemia, and metastatic calcification. (13408285)
1957
41
Calcified scleral nodules in hypervitaminosis D. (14361626)
1955
42
Dentine dysplasia associated with rheumatoid arthritis and hypervitaminosis D. (13224191)
1955
43
Kidney lesions in experimental hypervitaminosis D; a microradiographic and microangiographic study. (13238663)
1955
44
Resistant rickets? incomplete fanconi syndrome; bilateral femoral supracondylar osteotomy; hypervitaminosis D. (14864530)
1951
45
Skeletal and periarticular manifestations of hypervitaminosis D. (14799663)
1951
46
Hypervitaminosis D; report of nine cases. (18909525)
1948
47
The solar irradiation of children with special reference to hypervitaminosis D. (21031954)
1934
48
The mode of action of vitamin D: Studies on hypervitaminosis D. The influence of the calcium-phosphate intake. (16744588)
1931
49
The phosphorus distribution in blood and the calcium and phosphorus excretion during hypervitaminosis D. (16744406)
1930
50
Hypervitaminosis and vitamin balance: Part II. The specificity of vitamin D in irradiated ergosterol poisoning. Part III. The pathology of hypervitaminosis D. (16744212)
1929

Variations for Hypervitaminosis D

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Expression for genes affiliated with Hypervitaminosis D

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis D

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Pathways for genes affiliated with Hypervitaminosis D

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 30KEGG, 53QIAGEN
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Pathways related to Hypervitaminosis D according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5PTH, CYP27B1
29.5PTH, CYP27B1
39.5TRPV5, TRPV6
4
Show member pathways
9.5TRPV5, TRPV6
59.5TRPV6, TRPV5
69.4FGF23, PTH
79.2TRPV5, KL
8
Show member pathways
9.0FGF23, KL
9
Show member pathways
9.0FGF23, KL
10
Show member pathways
8.9TRPV6, TRPV5, FGF23

Compounds for genes affiliated with Hypervitaminosis D

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61Tocris Bioscience, 29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1amg 9810619.7TRPV6, TRPV5
25-iodoresiniferatoxin61 2910.7TRPV6, TRPV5
3paricalcitol45 1110.7PTH, CYP27B1
4hc 067047619.7TRPV6, TRPV5
5capsazepine61 45 2911.6TRPV6, TRPV5
6ruthenium red299.6TRPV6, TRPV5
7inositol 1,4,5 trisphosphate459.5TRPV6, PTH
8mg2+299.5TRPV5, TRPV6
9anandamide61 45 29 2412.4TRPV5, TRPV6
1025-hydroxyvitamin d459.2FGF23, PTH, CYP27B1
11phosphorus459.2CYP27B1, PTH, FGF23
12calcitriol45 61 24 1111.7CYP27B1, PTH, TRPV6, FGF23
131,25 dihydroxy vitamin d3458.2FGF23, TRPV5, TRPV6, PTH, CYP27B1
14vitamin d458.2CYP27B1, PTH, TRPV6, TRPV5, FGF23
15tyrosine457.8CYP27B1, PTH, KL, FGF23
16calcium45 51 24 1110.4CYP27B1, PTH, KL, TRPV6, TRPV5, FGF23

GO Terms for genes affiliated with Hypervitaminosis D

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16Gene Ontology
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Cellular components related to Hypervitaminosis D according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7TRPV5, TRPV6, KL
2extracellular spaceGO:0056158.3FGF23, KL, PTH

Biological processes related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:0332809.8PTH, CYP27B1
2calcium ion transmembrane transportGO:0705889.6TRPV5, TRPV6
3positive regulation of vitamin D 24-hydroxylase activityGO:0109809.6FGF23, CYP27B1
4vitamin D catabolic processGO:0423699.6FGF23, CYP27B1
5positive regulation of bone mineralizationGO:0305019.4PTH, KL
6ion transmembrane transportGO:0342209.4TRPV5, TRPV6
7calcium ion homeostasisGO:0550749.3KL, CYP27B1
8positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:0900809.3KL, FGF23
9calcium ion transportGO:0068169.2TRPV5, TRPV6, CYP27B1
10phosphatidylinositol-mediated signalingGO:0480159.1FGF23, KL
11insulin receptor signaling pathwayGO:0082869.1FGF23, KL
12fibroblast growth factor receptor signaling pathwayGO:0085439.0KL, FGF23
13epidermal growth factor receptor signaling pathwayGO:0071739.0FGF23, KL
14Fc-epsilon receptor signaling pathwayGO:0380958.7FGF23, KL

Molecular functions related to Hypervitaminosis D according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calmodulin bindingGO:0055169.5TRPV5, TRPV6
2calcium channel activityGO:0052629.4TRPV5, TRPV6
3hormone activityGO:0051798.9KL, PTH

Products for genes affiliated with Hypervitaminosis D

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  • Antibodies
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Sources for Hypervitaminosis D

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet