MCID: HYP057
MIFTS: 40

Hypervitaminosis D

Categories: Metabolic diseases

Aliases & Classifications for Hypervitaminosis D

MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 72 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9971
ICD10 32 E67.3
ICD9CM 34 278.4
SNOMED-CT 64 190969000 27712000
UMLS 69 C1442839

Summaries for Hypervitaminosis D

MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and rickets. An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Negative regulation of FGFR3 signaling and Signaling by FGFR2. The drugs Vitamin D and Cholecalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and placenta, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0 to... more...

Related Diseases for Hypervitaminosis D

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 31.3 FGF23 GALNT3
2 rickets 29.5 CYP27B1 FGF23 PTH
3 hyperparathyroidism 29.2 CYP27B1 FGF23 PTH
4 calcinosis 28.9 FGF23 GALNT3 KL
5 osteoporosis 28.5 CYP27B1 FGF23 KL PTH
6 calciphylaxis 10.1 FGF23 PTH
7 hypercalcemia, infantile, 1 10.1
8 oncogenic osteomalacia 10.1 FGF23 PTH
9 impaired renal function disease 10.1 FGF23 PTH
10 pulmonary alveolar microlithiasis 10.1 FGF23 PTH
11 metaphyseal chondrodysplasia, jansen type 10.1 FGF23 PTH
12 parathyroid gland disease 10.0 FGF23 PTH
13 renal osteodystrophy 10.0 FGF23 PTH
14 spondylosis 10.0 KL PTH
15 tracheal calcification 10.0 FGF23 KL
16 hypophosphatemic rickets, x-linked recessive 10.0 CYP27B1 FGF23
17 bone remodeling disease 10.0 FGF23 PTH
18 hypophosphatemia 9.9 FGF23 PTH
19 hypoparathyroidism 9.9 FGF23 PTH
20 diabetes insipidus, nephrogenic, autosomal 9.9
21 arteriosclerosis 9.9
22 diabetes insipidus 9.9
23 primary hyperparathyroidism 9.8 FGF23 PTH
24 hypophosphatemic rickets, autosomal dominant 9.8 FGF23 GALNT3
25 secondary hyperparathyroidism of renal origin 9.8 CYP27B1 FGF23 PTH
26 chronic kidney failure 9.7 CYP27B1 FGF23 PTH
27 alagille syndrome 1 9.7
28 fibrosis of extraocular muscles, congenital, 1 9.7
29 endosteal hyperostosis, autosomal dominant 9.7
30 neurofibromatosis, type iv, of riccardi 9.7
31 rheumatoid arthritis 9.7
32 arterial calcification, generalized, of infancy, 1 9.7
33 cystic fibrosis 9.7
34 hypervitaminosis a 9.7
35 intracranial hypertension, idiopathic 9.7
36 aging 9.7
37 branchiootic syndrome 1 9.7
38 mycobacterium tuberculosis 1 9.7
39 bone mineral density quantitative trait locus 8 9.7
40 bone mineral density quantitative trait locus 15 9.7
41 arthritis 9.7
42 dentin dysplasia 9.7
43 mannosidosis 9.7
44 fanconi syndrome 9.7
45 pneumocystosis 9.7
46 pulmonary tuberculosis 9.7
47 pneumonia 9.7
48 periodontitis 9.7
49 urinary system disease 9.7 FGF23 KL PTH
50 lacrimoauriculodentodigital syndrome 9.7 FGF23 GALNT3

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D

Symptoms & Phenotypes for Hypervitaminosis D

MGI Mouse Phenotypes related to Hypervitaminosis D:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 FGF23 PTH GALNT3 CYP27B1 KL
2 cellular MP:0005384 9.89 KL PTH GALNT3 CYP27B1 TRPV5
3 growth/size/body region MP:0005378 9.88 FGF23 PTH GALNT3 CYP27B1 KL TRPV5
4 hematopoietic system MP:0005397 9.85 PTH GALNT3 CYP27B1 KL FGF23 TRPV5
5 endocrine/exocrine gland MP:0005379 9.83 FGF23 PTH GALNT3 CYP27B1 KL
6 homeostasis/metabolism MP:0005376 9.8 FGF23 PTH GALNT3 CYP27B1 KL TRPV5
7 craniofacial MP:0005382 9.78 PTH GALNT3 CYP27B1 KL
8 digestive/alimentary MP:0005381 9.76 FGF23 GALNT3 KL TRPV5
9 immune system MP:0005387 9.73 FGF23 PTH GALNT3 CYP27B1 KL TRPV5
10 limbs/digits/tail MP:0005371 9.55 PTH GALNT3 CYP27B1 KL FGF23
11 renal/urinary system MP:0005367 9.35 GALNT3 CYP27B1 KL FGF23 TRPV5
12 skeleton MP:0005390 9.1 PTH GALNT3 TRPV5 CYP27B1 KL FGF23

Drugs & Therapeutics for Hypervitaminosis D

Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1406-16-2
2
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 10883523 5280795 6221
3
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
4 Calcifediol Phase 4 19356-17-3
5 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
6 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
7 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
8 Hydroxycholecalciferols Phase 4
9 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1
10 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
12 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
13 Hepcidins Phase 2
14 Pharmaceutical Solutions Phase 2
15 Anti-Infective Agents Phase 2
16 Olive Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
2 Randomized Study of Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease Active, not recruiting NCT01909115 Phase 3
3 Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Completed NCT01838447 Phase 2
4 Vitamin D as a Modifier of Serum Hepcidin in Children With Chronic Kidney Disease Completed NCT01532349 Phase 2 Cholecalciferol
5 Vitamin D and Severe Asthma Exacerbations Completed NCT01921894 Phase 1
6 Pilot Trial to Evaluate the Effect of Vitamin D on Melanocyte Biomarkers Completed NCT01477463 Vitamin D3;placebo and vitamin D
7 Efficacy of Vitamin D Therapy on Glucose Homeostasis in Obese Adolescents Completed NCT02414529 Vitamin D2;Placebo
8 Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women Active, not recruiting NCT02553044

Search NIH Clinical Center for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

Anatomical Context for Hypervitaminosis D

MalaCards organs/tissues related to Hypervitaminosis D:

38
Bone, Kidney, Placenta, Smooth Muscle

Publications for Hypervitaminosis D

Articles related to Hypervitaminosis D:

(show top 50) (show all 118)
# Title Authors Year
1
Vitamin D deficiency: It is time for reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." ( 28652074 )
2017
2
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? ( 28734988 )
2017
3
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. ( 28114469 )
2017
4
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. ( 28063517 )
2017
5
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. ( 26897163 )
2016
6
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. ( 26995293 )
2016
7
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. ( 25831571 )
2015
8
Reversible vascular calcifications associated with hypervitaminosis D. ( 26318020 )
2015
9
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. ( 26557587 )
2015
10
Hypervitaminosis-D, an uncommon reality! ( 25906526 )
2014
11
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. ( 25281651 )
2014
12
Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report. ( 24571630 )
2014
13
Tanning beds and hypervitaminosis D: a case report. ( 24887628 )
2014
14
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. ( 23756934 )
2013
15
Hypervitaminosis D in guinea pigs with I+-mannosidosis. ( 23582422 )
2013
16
Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. ( 23895994 )
2013
17
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. ( 23396467 )
2013
18
Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment. ( 25149241 )
2013
19
Serum levels of 3-epi-25-OH-D3 during hypervitaminosis D in clinical practice. ( 23038681 )
2012
20
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. ( 23087723 )
2012
21
Hypervitaminosis D associated with a vitamin D dispensing error. ( 21917555 )
2011
22
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. ( 22461833 )
2011
23
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. ( 19619235 )
2010
24
Neurofibromatosis, pathological fracture and hypervitaminosis-D. ( 21048240 )
2010
25
Hypercalcemia due to hypervitaminosis D: report of seven patients. ( 19339514 )
2009
26
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. ( 16699077 )
2006
27
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. ( 16731043 )
2006
28
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. ( 16148038 )
2005
29
Risk of hypervitaminosis D from prolonged feeding of high vitamin D premature infant formula. ( 15310310 )
2004
30
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. ( 12002522 )
2002
31
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. ( 10887751 )
2000
32
Hypercalcemia and hypervitaminosis D in two lambs. ( 10754674 )
2000
33
Dental changes in hypervitaminosis D. ( 9574950 )
1998
34
Hypervitaminosis D: Report on three patients. ( 17341976 )
1998
35
[Hypervitaminosis D in institutionalized elderly in Buenos Aires]. ( 9435366 )
1997
36
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. ( 7733425 )
1995
37
Hypervitaminosis D after prolonged feeding with a premature formula. ( 8233752 )
1993
38
Hypervitaminosis D associated with drinking milk. ( 1313547 )
1992
39
Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. ( 2163637 )
1990
40
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. ( 2109995 )
1990
41
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. ( 3207390 )
1988
42
Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. ( 2820185 )
1987
43
Severe depressive illness in the context of hypervitaminosis D. ( 3664111 )
1987
44
The osteodystrophy of hypervitaminosis D: a metabolic study. ( 3498181 )
1986
45
Effect of alkali on metastatic calcification produced by hypervitaminosis D. ( 6098694 )
1984
46
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. ( 6091851 )
1984
47
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. ( 6837312 )
1983
48
Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D. ( 6246506 )
1980
49
Effect of hypervitaminosis D on skeletal plutonium levels in mice. ( 7429853 )
1980
50
A method for studying plasma transport of vitamin D applicable to hypervitaminosis D. ( 761406 )
1979

Variations for Hypervitaminosis D

Expression for Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for Hypervitaminosis D

GO Terms for Hypervitaminosis D

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 FGF23 KL PTH
2 phosphatidylinositol phosphorylation GO:0046854 9.51 FGF23 KL
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.5 FGF23 GALNT3 KL
4 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.48 FGF23 KL
5 positive regulation of bone mineralization GO:0030501 9.46 KL PTH
6 regulation of bone mineralization GO:0030500 9.43 CYP27B1 FGF23
7 response to vitamin D GO:0033280 9.4 CYP27B1 PTH
8 vitamin D metabolic process GO:0042359 9.37 CYP27B1 FGF23
9 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.26 FGF23 KL
10 vitamin D catabolic process GO:0042369 9.16 CYP27B1 FGF23
11 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.96 CYP27B1 FGF23
12 calcium ion homeostasis GO:0055074 8.8 CYP27B1 KL TRPV5

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.32 FGF23 KL
2 hormone activity GO:0005179 9.26 KL PTH
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF23 KL
4 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF23 KL
5 fibroblast growth factor receptor binding GO:0005104 8.62 FGF23 KL

Sources for Hypervitaminosis D

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....