MCID: HYP057
MIFTS: 35

Hypervitaminosis D malady

Metabolic diseases category

Aliases & Classifications for Hypervitaminosis D

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Hypervitaminosis D, Aliases & Descriptions:

Name: Hypervitaminosis D 9 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:9971
ICD9CM27 278.4
SNOMED-CT55 190969000, 27712000
ICD1025 E67.3

Summaries for Hypervitaminosis D

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MalaCards based summary: Hypervitaminosis D is related to rickets and hypercalcemia. An important gene associated with Hypervitaminosis D is PTH (parathyroid hormone), and among its related pathways are Vitamin D synthesis and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds 5-iodoresiniferatoxin and hc 067047 have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Related Diseases for Hypervitaminosis D

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Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to hypervitaminosis d

Symptoms for Hypervitaminosis D

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Drugs & Therapeutics for Hypervitaminosis D

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Drug clinical trials:

Search ClinicalTrials for Hypervitaminosis D

Search NIH Clinical Center for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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MalaCards organs/tissues related to Hypervitaminosis D:

31
Bone, Kidney, Smooth muscle

Animal Models for Hypervitaminosis D or affiliated genes

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Publications for Hypervitaminosis D

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Articles related to Hypervitaminosis D:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. (25831571)
2015
2
Tanning beds and hypervitaminosis D: a case report. (24887628)
2014
3
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. (25281651)
2014
4
Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report. (24571630)
2014
5
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. (23756934)
2013
6
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
7
Hypervitaminosis D associated with a vitamin D dispensing error. (21917555)
2011
8
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. (22461833)
2011
9
Hypercalcemia due to hypervitaminosis D: report of seven patients. (19339514)
2009
10
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. (12002522)
2002
11
Hypervitaminosis D: Report on three patients. (17341976)
1998
12
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. (7733425)
1995
13
Hypervitaminosis D after prolonged feeding with a premature formula. (8233752)
1993
14
Hypervitaminosis D associated with drinking milk. (1313547)
1992
15
Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. (2163637)
1990
16
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. (3207390)
1988
17
The osteodystrophy of hypervitaminosis D: a metabolic study. (3498181)
1986
18
Effect of alkali on metastatic calcification produced by hypervitaminosis D. (6098694)
1984
19
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. (6091851)
1984
20
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. (6837312)
1983
21
Effect of hypervitaminosis D on skeletal plutonium levels in mice. (7429853)
1980
22
Ultrastructure of cardiovascular lesions induced by hypervitaminosis D and its withdrawal. (224365)
1978
23
Hypervitaminosis D in sheep. An experimental study. (217259)
1978
24
Hypervitaminosis D in rabbits. (1253099)
1976
25
Bone pathology in hypervitaminosis D an experimental study in young pigs. (182436)
1976
26
Nephropathy after acute hypervitaminosis-D (an experimental study). (4791939)
1973
27
Metabolic effect of pyridinolcarbamate on the vascular wall of rats with hypervitaminosis D. (4262650)
1972
28
Microradiographic evaluation of bone from cows with experimental hypervitaminosis D, diet-induced hypocalcemia, and naturally occurring parturient paresis. (5050206)
1972
29
Persistent defects of bone formation in young rats following maternal hypervitaminosis D 2 . (5055372)
1972
30
Effects of hypervitaminosis D on bones and teeth of rats. (4261660)
1971
31
Effect of hypervitaminosis D upon the phospholipids of metaphyseal and diaphyseal bone. (5299638)
1966
32
The pathology of hypervitaminosis D in cattle. (5957331)
1966
33
Hypervitaminosis D in green iguanas. (22413201)
1966
34
Kidney function and structure in experimental hyperparathyroidism and hypervitaminosis D. (13890267)
1962
35
Hypervitaminosis D with osteosclerosis. (13722405)
1961
36
Response of hemoglobin and cellular elements of blood after hypervitaminosis D in monkeys. (13769311)
1960
37
Experimental arteriosclerosis due to hypervitaminosis D. (13712151)
1960
38
The antagonism between cortisone and vitamin D: experiments on hypervitaminosis D inrats. (13539297)
1958
39
The effect of cortisone in experimental hypervitaminosis D. (13562007)
1958
40
An experimental histologic study of hypervitaminosis D. (13533519)
1958
41
Hypervitaminosis D in monkeys; a clinical and pathologic study. (13498130)
1958
42
Experimental hypervitaminosis D: hypercalcemia, hypermucoproteinemia, and metastatic calcification. (13408285)
1957
43
Calcified scleral nodules in hypervitaminosis D. (14361626)
1955
44
Dentine dysplasia associated with rheumatoid arthritis and hypervitaminosis D. (13224191)
1955
45
Resistant rickets? incomplete fanconi syndrome; bilateral femoral supracondylar osteotomy; hypervitaminosis D. (14864530)
1951
46
Skeletal and periarticular manifestations of hypervitaminosis D. (14799663)
1951
47
Hypervitaminosis D; report of nine cases. (18909525)
1948
48
The solar irradiation of children with special reference to hypervitaminosis D. (21031954)
1934
49
The mode of action of vitamin D: Studies on hypervitaminosis D. The influence of the calcium-phosphate intake. (16744588)
1931
50
The phosphorus distribution in blood and the calcium and phosphorus excretion during hypervitaminosis D. (16744406)
1930

Variations for Hypervitaminosis D

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Expression for genes affiliated with Hypervitaminosis D

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Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for genes affiliated with Hypervitaminosis D

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Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5PTH, CYP27B1
29.5PTH, CYP27B1
3
Show member pathways
9.5TRPV5, TRPV6
49.5TRPV6, TRPV5
59.4FGF23, PTH
69.2TRPV5, KL
7
Show member pathways
9.0FGF23, KL
8
Show member pathways
9.0FGF23, KL
9
Show member pathways
8.9TRPV6, TRPV5, FGF23

Compounds for genes affiliated with Hypervitaminosis D

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Compounds related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
15-iodoresiniferatoxin59 2810.7TRPV5, TRPV6
2hc 067047599.7TRPV5, TRPV6
3paricalcitol43 1210.7CYP27B1, PTH
4amg 9810599.7TRPV5, TRPV6
5ruthenium red289.6TRPV5, TRPV6
6capsazepine59 43 2811.6TRPV6, TRPV5
7inositol 1,4,5 trisphosphate439.5TRPV6, PTH
8mg2+289.5TRPV5, TRPV6
9anandamide59 43 28 2412.4TRPV6, TRPV5
1025-hydroxyvitamin d439.2FGF23, PTH, CYP27B1
11phosphorus439.2FGF23, PTH, CYP27B1
12calcitriol43 59 24 1211.7FGF23, TRPV6, CYP27B1, PTH
131,25 dihydroxy vitamin d3438.2FGF23, CYP27B1, PTH, TRPV6, TRPV5
14vitamin d438.2TRPV6, TRPV5, FGF23, CYP27B1, PTH
15tyrosine437.8KL, PTH, CYP27B1, FGF23
16calcium43 49 24 1210.4FGF23, PTH, TRPV5, TRPV6, CYP27B1, KL

GO Terms for genes affiliated with Hypervitaminosis D

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Cellular components related to Hypervitaminosis D according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7TRPV5, TRPV6, KL
2extracellular spaceGO:00056158.3FGF23, KL, PTH

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:00332809.8CYP27B1, PTH
2calcium ion transmembrane transportGO:00705889.6TRPV5, TRPV6
3vitamin D catabolic processGO:00423699.6CYP27B1, FGF23
4positive regulation of vitamin D 24-hydroxylase activityGO:00109809.6CYP27B1, FGF23
5positive regulation of bone mineralizationGO:00305019.4KL, PTH
6ion transmembrane transportGO:00342209.4TRPV6, TRPV5
7calcium ion homeostasisGO:00550749.3KL, CYP27B1
8positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:00900809.3FGF23, KL
9calcium ion transportGO:00068169.2TRPV5, TRPV6, CYP27B1
10phosphatidylinositol-mediated signalingGO:00480159.1KL, FGF23
11insulin receptor signaling pathwayGO:00082869.1FGF23, KL
12fibroblast growth factor receptor signaling pathwayGO:00085439.0FGF23, KL
13epidermal growth factor receptor signaling pathwayGO:00071739.0KL, FGF23
14Fc-epsilon receptor signaling pathwayGO:00380958.7KL, FGF23

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calmodulin bindingGO:00055169.5TRPV5, TRPV6
2calcium channel activityGO:00052629.4TRPV5, TRPV6
3hormone activityGO:00051798.9KL, PTH

Products for genes affiliated with Hypervitaminosis D

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Sources for Hypervitaminosis D

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet