MCID: HYP057
MIFTS: 41

Hypervitaminosis D malady

Metabolic category

Summaries for Hypervitaminosis D

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33MalaCards
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MalaCards: Hypervitaminosis D is related to hypercalcemia and atherosclerosis. An important gene associated with Hypervitaminosis D is PTH (parathyroid hormone), and among its related pathways are Osteoblast Signaling and Calcium channels. The compounds amg 9810 and 5-iodoresiniferatoxin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Aliases & Classifications for Hypervitaminosis D

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

hypervitaminosis d 8 10 61


External Ids:

Disease Ontology8 DOID:9971
ICD9CM27 278.4
SNOMED-CT57 27712000, 190969000
ICD1025 E67.3

Related Diseases for Hypervitaminosis D

Sources:
17GeneCards, 18GeneDecks
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Diseases in the hypervitaminosis a family:

hypervitaminosis d

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.6FGF23, VDR, PTH, CYP27B1
2atherosclerosis30.3FGF23
3rickets30.3CYP27B1, VDR, PTH
4osteoporosis30.1KL, CYP27B1, FGF23, PTH, VDR
5hypervitaminosis a10.8
6diabetes insipidus10.3
7nephrogenic diabetes insipidus10.3
8arteriosclerosis10.3
9neurofibromatosis10.1
10cystic fibrosis10.1
11pseudotumor cerebri10.1
12fanconi syndrome10.1
13alagille syndrome10.1
14dentin dysplasia10.1
15arthritis10.1
16hypertension10.0PTH
17prostatitis10.0VDR
18sarcoidosis10.0CYP27B1
19hyperostosis10.0FGF23
20uremia10.0PTH, VDR
21vitamin d-dependent rickets type ii10.0VDR, CYP27B1
22rickets, vitamin d-resistant, type iia10.0CYP27B1, VDR
23hypoparathyroidism10.0FGF23, PTH
24hyperthyroidism10.0FGF23, PTH
25parathyroid adenoma10.0PTH, VDR
26leukemia10.0CYP27B1, VDR
27osteoporosis, postmenopausal10.0VDR, PTH, CYP27B1
28tumoral calcinosis, hyperphosphatemic10.0FGF23, KL
29hyperphosphatemic familial tumoral calcinosis10.0KL, FGF23
30prostate cancer10.0TRPV6, VDR, CYP27B1
31renal osteodystrophy10.0VDR, FGF23, PTH
32diabetes mellitus10.0VDR, CYP27B1, PTH
33nephrolithiasis10.0VDR, FGF23, PTH
34primary hyperoxaluria10.0VDR, FGF23, PTH
35calcinosis10.0FGF23, KL, PTH
36x-linked hypophosphatemia10.0FGF23, CYP27B1, VDR
37pulmonary emphysema10.0KL, FGF23
38graves' disease10.0VDR, FGF23, CYP27B1
39breast cancer10.0STC2, PTH, CYP27B1, VDR
40primary hyperparathyroidism10.0CYP27B1, PTH, VDR, FGF23
41secondary hyperparathyroidism of renal origin10.0FGF23, CYP27B1, VDR, PTH
42secondary syphilis10.0PTH, VDR, CYP27B1, FGF23
43chronic kidney failure10.0PTH, CYP27B1, VDR, FGF23
44hyperphosphatemia10.0PTH, FGF23, VDR, KL
45hypophosphatemia10.0VDR, CYP27B1, FGF23, PTH, KL
46osteomalacia10.0KL, VDR, FGF23, PTH, CYP27B1
47hyperparathyroidism10.0VDR, CYP27B1, FGF23, KL, PTH

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to hypervitaminosis d

Clinical Features for Hypervitaminosis D

Drugs & Therapeutics for Hypervitaminosis D

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypervitaminosis D

Drug clinical trials:

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Search NIH Clinical Center for Hypervitaminosis D

Search CenterWatch for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

Anatomical Context for Hypervitaminosis D

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypervitaminosis D:

33
Bone marrow, Whole blood, Brain, Smooth muscle, Skeletal muscle, Liver, Thyroid, Adrenal gland, Skin, Fetal brain, Fetal liver, Fetal thyroid, Pituitary

Animal Models for Hypervitaminosis D or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypervitaminosis D

Sources:
51PubMed
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Articles related to Hypervitaminosis D:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. (23756934)
2013
2
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. (23396467)
2013
3
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
4
Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. (22215263)
2012
5
Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture. (14608074)
2003
6
In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis. (12654005)
2003
7
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. (12002522)
2002
8
Hyperostotic polyarthropathy in a rabbit--a suspected case of chronic hypervitaminosis A from a diet of carrots. (11702930)
2001
9
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. (10887751)
2000
10
Local disappearance of epiphyseal growth plates in rats with hypervitaminosis A. (9713809)
1998
11
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. (7733425)
1995
12
Effect of hypervitaminosis A on intestinal digestive & absorptive functions in rat. (8063349)
1994
13
Hypervitaminosis A and reproductive disorders in rabbits. (1320154)
1992
14
Hypervitaminosis A following long-term use of high-dose fish oil supplements. (2331929)
1990
15
Craniofacial dysmorphogenesis following hypervitaminosis A in mice. (3563929)
1987
16
Hepatic and dermatologic manifestations of chronic hypervitaminosis A in adults. Report of two cases. (2937294)
1986
17
Discordant hepatic uptake between Tc-99m sulfur colloid and Tc-99m DISIDA in hypervitaminosis A. (6539369)
1984
18
Hypervitaminosis A: a contributing factor to anemia in regular dialysis patients. (6540843)
1984
19
Inhibiting effects of hypervitaminosis A on development of fetal rat adrenal glands. (6543180)
1984
20
What is your diagnosis? Soft tissue calcifications, suggestive of hypervitaminosis A. (6654731)
1983
21
Protein-calorie deficiency and vitamin indiscretion in an atopic child who developed hypervitaminosis A. (6799241)
1982
22
Effect of dietary protein and hypervitaminosis A or C on tissue peroxidation and erythrocyte lysis of vitamin E deficiency. (7160964)
1982
23
Development of hypervitaminosis A in a patient on long-term parenteral hyperalimentation. (6784095)
1981
24
A lethal hypervitaminosis A syndrome in young monkeys (Macacus fascicularis) following a single intramuscular dose of a water-miscible preparation containing vitamins A, D2 and E. (6976950)
1981
25
Hypervitaminosis A combined with calcium deficiency in rats. (447448)
1979
26
Influence of various levels of hypervitaminosis A and zinc deficiency on teratogenesis and DNA synthesis in the rat. (112706)
1979
27
Hypervitaminosis A in a patient with alopecia receiving renal dialysis. (453904)
1979
28
Quantitative studies on acid phosphatase in developing rat bones and teeth during hypervitaminosis D. (1054977)
1975
29
Skeletal deformities following chronic hypervitaminosis A; a case report. (4436364)
1974
30
Hypervitaminosis D and glycosaminoglycan metabolism in rats fed normal and high fat cholesterol diets. (4274028)
1974
31
An electron microscopic study of the effects of hypervitaminosis A on the maternal-embryonic relationship of the rat at 8 days of pregnancy. (4713336)
1973
32
Histochemistry of various acid phosphatases in developing bones and teeth in hypervitaminosis D in the rat. (4513106)
1973
33
Microradiographic evaluation of bone from cows with experimental hypervitaminosis D, diet-induced hypocalcemia, and naturally occurring parturient paresis. (5050206)
1972
34
Prevention of vascular lesions by chondroitin sulfate A in the coronary artery and aorta of rats induced by a hypervitaminosis D, cholesterol-containing diet. (5069576)
1972
35
Composition of the dura mater in chronic bovine hypervitaminosis A. (4256506)
1971
36
Ocular mucoid depletion in hypervitaminosis A. (4260178)
1971
37
Induction of aortic and coronary athero-arteriosclerosis in rats fed a hypervitaminosis D, cholesterol-containing diet. (5316177)
1971
38
Hypothalamic-hypophysial adrenal and thyroid systems: observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A. (5436115)
1970
39
Production of cleft palate with dexamethasone and hypervitaminosis A in rat embryos. (4320730)
1970
40
Dental malformations in rat embryos with exencephaly induced by hypervitaminosis A. (5236137)
1967
41
Electroretinographic studies on experimental hypervitaminosis A and vitamin A deficiency. I. The influence of vitamin A on the ERG of rabbits]. (5626341)
1967
42
Electroretinographic studies on experimental hypervitaminosis A and vitamin A deficiency. II. ERG in normal rats and the influence of urethane on the ERG]. (5626638)
1967
43
Effect of hypervitaminosis D upon the phospholipids of metaphyseal and diaphyseal bone. (5299638)
1966
44
CISTERNAL CEREBROSPINAL FLUID PRESSURE DURING DEVELOPMENT OF CHRONIC BOVINE HYPERVITAMINOSIS A. (14344978)
1965
45
Testicular degeneration in rats during hypervitaminosis A. (5875155)
1965
46
Acute hypervitaminosis A in guinea pigs. II. Effects on delayed-type hypersensitivity. (13995247)
1963
47
Effects of hypervitaminosis A on palate development in two strains of mice. (13782692)
1960
48
Dentine dysplasia associated with rheumatoid arthritis and hypervitaminosis D. (13224191)
1955
49
Hypervitaminosis A in young ducks; the epiphyseal cartilages. (12996190)
1953
50
Chronic moderate hypervitaminosis D in young dogs. (20239960)
1947

Genetic Variations for Hypervitaminosis D

Expression for genes affiliated with Hypervitaminosis D

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for genes affiliated with Hypervitaminosis D

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 30KEGG
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Pathways related to Hypervitaminosis D according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGF23, PTH
29.6TRPV6, TRPV5
3
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.5PTH, VDR
4
Hide members
9.5KL, FGF23
5
Hide members
9.5FGF23, KL
69.4CYP27B1, VDR
79.3VDR, TRPV6
8
Vitamin D2 (ergocalciferol) metabolism
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9.1PTH, CYP27B1, VDR
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.1VDR, CYP27B1, PTH
109.0VDR, TRPV5, KL

Compounds for genes affiliated with Hypervitaminosis D

Sources:
60Tocris Bioscience, 29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1amg 9810609.9TRPV5, TRPV6
25-iodoresiniferatoxin60 2910.9TRPV5, TRPV6
3hc 067047609.9TRPV5, TRPV6
4estrogen459.9VDR
5doxercalciferol459.8VDR, PTH
6ruthenium red299.8TRPV5, TRPV6
7capsazepine45 60 2911.8TRPV5, TRPV6
8Calcidiol11 2410.8VDR, CYP27B1
9mg2+299.8TRPV6, TRPV5
10calcifediol609.8VDR, CYP27B1
11gemini459.8VDR, CYP27B1
12Ergocalciferol11 2410.7CYP27B1, VDR
13alfacalcidol45 60 1111.7VDR, CYP27B1
1424,25-dihydroxyvitamin d3459.7VDR, CYP27B1
15calcipotriol45 60 29 1112.6VDR, CYP27B1
16deoxypyridinoline459.6PTH, VDR
17eb 108945 6010.6CYP27B1, VDR
18alendronate45 50 1111.6VDR, PTH
19anandamide45 29 60 2412.5TRPV6, TRPV5
20paricalcitol45 1110.4VDR, CYP27B1, PTH
21pge2459.1PTH, CYP27B1, VDR
2225-hydroxyvitamin d459.0VDR, CYP27B1, FGF23, PTH
23phosphorus458.9PTH, FGF23, CYP27B1, VDR
24estradiol45 11 2410.6STC2, CYP27B1, PTH
25calcitriol45 60 11 2411.4TRPV6, VDR, CYP27B1, FGF23, PTH
261,25 dihydroxy vitamin d3458.1PTH, FGF23, CYP27B1, VDR, TRPV6, TRPV5
27vitamin d458.1TRPV5, TRPV6, VDR, CYP27B1, FGF23, PTH
28calcium45 50 11 249.8KL, STC2, TRPV5, TRPV6, VDR, CYP27B1

GO Terms for genes affiliated with Hypervitaminosis D

Sources:
16Gene Ontology
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Biological processes related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:0423699.7FGF23, CYP27B1
2positive regulation of bone mineralizationGO:0305019.7PTH, KL
3positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:0900809.6FGF23, KL
4positive regulation of keratinocyte differentiationGO:0456189.4CYP27B1, VDR
5calcium ion homeostasisGO:0550749.3CYP27B1, KL
6response to vitamin DGO:0332809.1STC2, CYP27B1
7positive regulation of vitamin D 24-hydroxylase activityGO:0109809.1FGF23, CYP27B1, VDR
8cellular calcium ion homeostasisGO:0068748.8STC2, VDR, PTH
9decidualizationGO:0466978.8CYP27B1, VDR, STC2
10calcium ion transportGO:0068168.7TRPV5, TRPV6, VDR, CYP27B1

Molecular functions related to Hypervitaminosis D according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:0052629.6TRPV6, TRPV5
2hormone activityGO:0051798.6PTH, STC2, KL

Products for genes affiliated with Hypervitaminosis D

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Sources for Hypervitaminosis D

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet