MCID: HYP057
MIFTS: 42

Hypervitaminosis D malady

Metabolic diseases category

Summaries for Hypervitaminosis D

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MalaCards: Hypervitaminosis D is related to hypercalcemia and atherosclerosis. An important gene associated with Hypervitaminosis D is PTH (parathyroid hormone), and among its related pathways are Osteoblast Signaling and Calcium channels. The compounds amg 9810 and 5-iodoresiniferatoxin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Aliases & Classifications for Hypervitaminosis D

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

hypervitaminosis d 8 10 60


External Ids:

Disease Ontology8 DOID:9971
ICD9CM27 278.4
SNOMED-CT56 27712000, 190969000
ICD1025 E67.3

Related Diseases for Hypervitaminosis D

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17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

hypervitaminosis d

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.6PTH, FGF23, CYP27B1, VDR
2atherosclerosis30.3FGF23
3rickets30.3PTH, CYP27B1, VDR
4calcinosis30.3PTH, FGF23, KL
5hyperparathyroidism30.0KL, VDR, CYP27B1, FGF23, PTH
6osteoporosis30.0KL, VDR, CYP27B1, FGF23, PTH
7hypervitaminosis a10.7
8diabetes insipidus10.2
9nephrogenic diabetes insipidus10.2
10arteriosclerosis10.2
11neurofibromatosis10.1
12cystic fibrosis10.1
13pseudotumor cerebri10.1
14fanconi syndrome10.1
15alagille syndrome10.1
16dentin dysplasia10.1
17arthritis10.1
18coronary arteriosclerosis10.1
19osteosclerosis10.1
20periodontitis10.1
21pneumonia10.1
22rheumatoid arthritis10.1
23hypertension10.0PTH
24prostatitis10.0VDR
25sarcoidosis10.0CYP27B1
26hyperostosis10.0FGF23
27uremia10.0VDR, PTH
28vitamin d-dependent rickets type ii10.0VDR, CYP27B1
29rickets, vitamin d-resistant, type iia10.0CYP27B1, VDR
30hypoparathyroidism10.0FGF23, PTH
31hyperthyroidism10.0PTH, FGF23
32parathyroid adenoma10.0PTH, VDR
33leukemia10.0CYP27B1, VDR
34osteoporosis, postmenopausal10.0PTH, CYP27B1, VDR
35hyperphosphatemic familial tumoral calcinosis10.0KL, FGF23
36tumoral calcinosis, hyperphosphatemic10.0KL, FGF23
37prostate cancer10.0CYP27B1, VDR, TRPV6
38renal osteodystrophy10.0PTH, FGF23, VDR
39diabetes mellitus10.0PTH, CYP27B1, VDR
40nephrolithiasis10.0PTH, FGF23, VDR
41primary hyperoxaluria10.0VDR, FGF23, PTH
42x-linked hypophosphatemia10.0FGF23, CYP27B1, VDR
43pulmonary emphysema10.0KL, FGF23
44graves' disease10.0VDR, CYP27B1, FGF23
45breast cancer10.0PTH, CYP27B1, VDR, STC2
46primary hyperparathyroidism10.0VDR, CYP27B1, FGF23, PTH
47secondary hyperparathyroidism of renal origin10.0VDR, CYP27B1, FGF23, PTH
48secondary syphilis10.0VDR, CYP27B1, FGF23, PTH
49chronic kidney failure10.0VDR, CYP27B1, FGF23, PTH
50hyperphosphatemia10.0KL, VDR, FGF23, PTH

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to hypervitaminosis d

Clinical Features for Hypervitaminosis D

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Drugs & Therapeutics for Hypervitaminosis D

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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32MalaCards
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MalaCards organs/tissues related to Hypervitaminosis D:

32
Bone, Kidney, Smooth muscle, Placenta

Animal Models for Hypervitaminosis D or affiliated genes

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36MGI
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Publications for Hypervitaminosis D

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50PubMed
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Articles related to Hypervitaminosis D:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. (23756934)
2013
2
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. (23396467)
2013
3
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. (23087723)
2012
4
Hypercalcemia, hypervitaminosis A and 3-epi-25-OH-D3 levels after consumption of an "over the counter" vitamin D remedy. a case report. (22426357)
2012
5
Hypervitaminosis D associated with a vitamin D dispensing error. (21917555)
2011
6
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. (22461833)
2011
7
Neurofibromatosis, pathological fracture and hypervitaminosis-D. (21048240)
2010
8
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. (19619235)
2010
9
Hypercalcemia due to hypervitaminosis D: report of seven patients. (19339514)
2009
10
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. (16699077)
2006
11
Hypercalcemia and hypervitaminosis D in two lambs. (10754674)
2000
12
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. (7733425)
1995
13
Hypervitaminosis D after prolonged feeding with a premature formula. (8233752)
1993
14
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. (3207390)
1988
15
Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. (2820185)
1987
16
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. (6091851)
1984
17
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. (6837312)
1983
18
Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D. (6246506)
1980
19
A method for studying plasma transport of vitamin D applicable to hypervitaminosis D. (761406)
1979
20
Deafness due to hypervitaminosis D. (87663)
1979
21
25-hydroxy-vitamin D levels in a patient with hypervitaminosis D. (672143)
1978
22
Bone scan findings in hypervitaminosis D: case report. (606746)
1977
23
Hypervitaminosis D and metastatic pulmonary calcification in a cow. (204097)
1977
24
Letter: Multiple factors in the hyperlipidaemia of hypervitaminosis D. (1191987)
1975
25
Quantitative studies on acid phosphatase in developing rat bones and teeth during hypervitaminosis D. (1054977)
1975
26
Nephropathy after acute hypervitaminosis-D (an experimental study). (4791939)
1973
27
Histochemistry of various acid phosphatases in developing bones and teeth in hypervitaminosis D in the rat. (4513106)
1973
28
Metabolic effect of pyridinolcarbamate on the vascular wall of rats with hypervitaminosis D. (4262650)
1972
29
Microradiographic evaluation of bone from cows with experimental hypervitaminosis D, diet-induced hypocalcemia, and naturally occurring parturient paresis. (5050206)
1972
30
Persistent defects of bone formation in young rats following maternal hypervitaminosis D 2 . (5055372)
1972
31
Effects of hypervitaminosis D on bones and teeth of rats. (4261660)
1971
32
Structural alterations in rat placenta following hypervitaminosis D 2 . (5314860)
1971
33
An autopsy case of hypervitaminosis D. (5631273)
1967
34
Hypervitaminosis D.--A case report. (5922345)
1966
35
Hypervitaminosis D and pneumocystis pneumonia in an infant. (4284290)
1965
36
EFFECTS OF HYPERVITAMINOSIS A AND D ON SKELETAL METABOLISM. (14165937)
1964
37
Kidney function and structure in experimental hyperparathyroidism and hypervitaminosis D. (13890267)
1962
38
The amelioration of hypervitaminosis D in rats with vitamin A. (13879694)
1962
39
Effect of hypervitaminosis D on serum factors in the rabbit. (13889698)
1962
40
Hypervitaminosis D with osteosclerosis. (13722405)
1961
41
Response of hemoglobin and cellular elements of blood after hypervitaminosis D in monkeys. (13769311)
1960
42
The antagonism between cortisone and vitamin D: experiments on hypervitaminosis D inrats. (13539297)
1958
43
An experimental histologic study of hypervitaminosis D. (13533519)
1958
44
Dentine dysplasia associated with rheumatoid arthritis and hypervitaminosis D. (13224191)
1955
45
Kidney lesions in experimental hypervitaminosis D; a microradiographic and microangiographic study. (13238663)
1955
46
Comparative study of the reaction to injury. II. Hypervitaminosis D in the frog with special reference to the lime sacs. (13064930)
1953
47
Multiple calcinosis associated with hypervitaminosis D; report of a case. (18914973)
1948
48
Hypercalcemia and hypervitaminosis D. (20342826)
1947
49
The solar irradiation of children with special reference to hypervitaminosis D. (21031954)
1934
50
Hypervitaminosis and vitamin balance: Part II. The specificity of vitamin D in irradiated ergosterol poisoning. Part III. The pathology of hypervitaminosis D. (16744212)
1929

Genetic Variations for Hypervitaminosis D

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Expression for genes affiliated with Hypervitaminosis D

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis D

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Pathways for genes affiliated with Hypervitaminosis D

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37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Hypervitaminosis D according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGF23, PTH
29.6TRPV6, TRPV5
3
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.5PTH, VDR
4
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9.5KL, FGF23
5
Hide members
9.5FGF23, KL
69.4CYP27B1, VDR
79.3VDR, TRPV6
8
Vitamin D2 (ergocalciferol) metabolism
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9.1PTH, CYP27B1, VDR
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.1VDR, CYP27B1, PTH
109.0VDR, TRPV5, KL

Compounds for genes affiliated with Hypervitaminosis D

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59Tocris Bioscience, 28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1amg 9810599.9TRPV5, TRPV6
25-iodoresiniferatoxin59 2810.9TRPV5, TRPV6
3hc 067047599.9TRPV5, TRPV6
4estrogen449.9VDR
5doxercalciferol449.8VDR, PTH
6ruthenium red289.8TRPV5, TRPV6
7capsazepine44 59 2811.8TRPV5, TRPV6
8Calcidiol11 2410.8VDR, CYP27B1
9mg2+289.8TRPV6, TRPV5
10calcifediol599.8VDR, CYP27B1
11gemini449.8VDR, CYP27B1
12Ergocalciferol11 2410.7CYP27B1, VDR
13alfacalcidol44 59 1111.7VDR, CYP27B1
1424,25-dihydroxyvitamin d3449.7VDR, CYP27B1
15calcipotriol44 59 28 1112.6VDR, CYP27B1
16deoxypyridinoline449.6PTH, VDR
17eb 108944 5910.6CYP27B1, VDR
18alendronate44 49 1111.6VDR, PTH
19anandamide44 28 59 2412.5TRPV6, TRPV5
20paricalcitol44 1110.4VDR, CYP27B1, PTH
21pge2449.1PTH, CYP27B1, VDR
2225-hydroxyvitamin d449.0VDR, CYP27B1, FGF23, PTH
23phosphorus448.9PTH, FGF23, CYP27B1, VDR
24estradiol44 11 2410.6STC2, CYP27B1, PTH
25calcitriol44 59 11 2411.4TRPV6, VDR, CYP27B1, FGF23, PTH
261,25 dihydroxy vitamin d3448.1PTH, FGF23, CYP27B1, VDR, TRPV6, TRPV5
27vitamin d448.1TRPV5, TRPV6, VDR, CYP27B1, FGF23, PTH
28calcium44 49 11 249.8KL, STC2, TRPV5, TRPV6, VDR, CYP27B1

GO Terms for genes affiliated with Hypervitaminosis D

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16Gene Ontology
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Biological processes related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:0423699.7FGF23, CYP27B1
2positive regulation of bone mineralizationGO:0305019.7PTH, KL
3positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:0900809.6FGF23, KL
4positive regulation of keratinocyte differentiationGO:0456189.4CYP27B1, VDR
5calcium ion homeostasisGO:0550749.3CYP27B1, KL
6response to vitamin DGO:0332809.1STC2, CYP27B1
7positive regulation of vitamin D 24-hydroxylase activityGO:0109809.1FGF23, CYP27B1, VDR
8cellular calcium ion homeostasisGO:0068748.8STC2, VDR, PTH
9decidualizationGO:0466978.8CYP27B1, VDR, STC2
10calcium ion transportGO:0068168.7TRPV5, TRPV6, VDR, CYP27B1

Molecular functions related to Hypervitaminosis D according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:0052629.6TRPV6, TRPV5
2hormone activityGO:0051798.6PTH, STC2, KL

Products for genes affiliated with Hypervitaminosis D

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  • Antibodies
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Sources for Hypervitaminosis D

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet