MCID: HYP057
MIFTS: 42

Hypervitaminosis D malady

Metabolic diseases category

Summaries for Hypervitaminosis D

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MalaCards: Hypervitaminosis D is related to hypercalcemia and atherosclerosis. An important gene associated with Hypervitaminosis D is PTH (parathyroid hormone), and among its related pathways are Osteoblast Signaling and Calcium channels. The compounds amg 9810 and 5-iodoresiniferatoxin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Aliases & Classifications for Hypervitaminosis D

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

hypervitaminosis d 8 10 60


External Ids:

Disease Ontology8 DOID:9971
ICD9CM27 278.4
SNOMED-CT56 27712000, 190969000
ICD1025 E67.3

Related Diseases for Hypervitaminosis D

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17GeneCards, 18GeneDecks
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Diseases in the Hypervitaminosis a family:

hypervitaminosis d

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.6PTH, FGF23, CYP27B1, VDR
2atherosclerosis30.3FGF23
3rickets30.3PTH, CYP27B1, VDR
4calcinosis30.3PTH, FGF23, KL
5hyperparathyroidism30.0KL, VDR, CYP27B1, FGF23, PTH
6osteoporosis30.0KL, VDR, CYP27B1, FGF23, PTH
7hypervitaminosis a10.7
8diabetes insipidus10.2
9nephrogenic diabetes insipidus10.2
10arteriosclerosis10.2
11neurofibromatosis10.1
12cystic fibrosis10.1
13pseudotumor cerebri10.1
14fanconi syndrome10.1
15alagille syndrome10.1
16dentin dysplasia10.1
17arthritis10.1
18coronary arteriosclerosis10.1
19osteosclerosis10.1
20periodontitis10.1
21pneumonia10.1
22rheumatoid arthritis10.1
23hypertension10.0PTH
24prostatitis10.0VDR
25sarcoidosis10.0CYP27B1
26hyperostosis10.0FGF23
27uremia10.0VDR, PTH
28vitamin d-dependent rickets type ii10.0VDR, CYP27B1
29rickets, vitamin d-resistant, type iia10.0CYP27B1, VDR
30hypoparathyroidism10.0FGF23, PTH
31hyperthyroidism10.0PTH, FGF23
32parathyroid adenoma10.0PTH, VDR
33leukemia10.0CYP27B1, VDR
34osteoporosis, postmenopausal10.0PTH, CYP27B1, VDR
35hyperphosphatemic familial tumoral calcinosis10.0KL, FGF23
36tumoral calcinosis, hyperphosphatemic10.0KL, FGF23
37prostate cancer10.0CYP27B1, VDR, TRPV6
38renal osteodystrophy10.0PTH, FGF23, VDR
39diabetes mellitus10.0PTH, CYP27B1, VDR
40nephrolithiasis10.0PTH, FGF23, VDR
41primary hyperoxaluria10.0VDR, FGF23, PTH
42x-linked hypophosphatemia10.0FGF23, CYP27B1, VDR
43pulmonary emphysema10.0KL, FGF23
44graves' disease10.0VDR, CYP27B1, FGF23
45breast cancer10.0PTH, CYP27B1, VDR, STC2
46primary hyperparathyroidism10.0VDR, CYP27B1, FGF23, PTH
47secondary hyperparathyroidism of renal origin10.0VDR, CYP27B1, FGF23, PTH
48secondary syphilis10.0VDR, CYP27B1, FGF23, PTH
49chronic kidney failure10.0VDR, CYP27B1, FGF23, PTH
50hyperphosphatemia10.0KL, VDR, FGF23, PTH

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to hypervitaminosis d

Clinical Features for Hypervitaminosis D

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Drugs & Therapeutics for Hypervitaminosis D

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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32MalaCards
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MalaCards organs/tissues related to Hypervitaminosis D:

32
Bone, Kidney, Smooth muscle, Placenta

Animal Models for Hypervitaminosis D or affiliated genes

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36MGI
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Publications for Hypervitaminosis D

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50PubMed
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Articles related to Hypervitaminosis D:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Hypervitaminosis D in guinea pigs with I+-mannosidosis. (23582422)
2013
2
Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. (23895994)
2013
3
Serum levels of 3-epi-25-OH-D3 during hypervitaminosis D in clinical practice. (23038681)
2012
4
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. (16148038)
2005
5
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. (12002522)
2002
6
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. (10887751)
2000
7
Hypervitaminosis D in institutionalized elderly in Buenos Aires]. (9435366)
1997
8
Hypervitaminosis D after prolonged feeding with a premature formula. (8233752)
1993
9
Hypervitaminosis D associated with drinking milk. (1313547)
1992
10
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. (2109995)
1990
11
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. (3207390)
1988
12
Severe depressive illness in the context of hypervitaminosis D. (3664111)
1987
13
Effect of alkali on metastatic calcification produced by hypervitaminosis D. (6098694)
1984
14
Ultrastructure of cardiovascular lesions induced by hypervitaminosis D and its withdrawal. (224365)
1978
15
Hypervitaminosis D in sheep. An experimental study. (217259)
1978
16
Hypervitaminosis D in fur-bearing animals. (213769)
1978
17
Hypervitaminosis D in rabbits. (1253099)
1976
18
Assessment of Hypervitaminosis D during the first trimester of pregnancy on the mouse embryo. Preliminary report. (1036958)
1976
19
Letter: Multiple factors in the hyperlipidaemia of hypervitaminosis D. (1191987)
1975
20
Structure of the osteocyte capsule in rats with hypervitaminosis-D and rickets. (1234824)
1975
21
Histochemistry of various acid phosphatases in developing bones and teeth in hypervitaminosis D in the rat. (4513106)
1973
22
Microradiographic evaluation of bone from cows with experimental hypervitaminosis D, diet-induced hypocalcemia, and naturally occurring parturient paresis. (5050206)
1972
23
Prevention of vascular lesions by chondroitin sulfate A in the coronary artery and aorta of rats induced by a hypervitaminosis D, cholesterol-containing diet. (5069576)
1972
24
Interdependence of fetal anomalies and placental impairment following maternal hypervitaminosis D and hypercortisonism. (4548304)
1972
25
Hypervitaminosis D in New World monkeys. (4975373)
1969
26
Interrelationships between thyrocalcitonin, parathyroid hormone and vitamin D: control of serum calcium in hypervitaminosis D. (4308479)
1969
27
Effect of chondroitin sulfate A and flavonoids on hypervitaminosis D in rats. (5306034)
1969
28
The effect of hypervitaminosis D on the periodontal membrane collagen in lathyritic rats. (4229980)
1967
29
An autopsy case of hypervitaminosis D. (5631273)
1967
30
Effect of hypervitaminosis D upon the phospholipids of metaphyseal and diaphyseal bone. (5299638)
1966
31
The pathology of hypervitaminosis D in cattle. (5957331)
1966
32
Hypervitaminosis D in green iguanas. (22413201)
1966
33
ALTERATIONS IN THE LIPIDS OF BONE CAUSED BY HYPERVITAMINOSIS A AND D. (14343141)
1965
34
Experimental arteriosclerosis due to hypervitaminosis D. (13712151)
1960
35
Hypervitaminosis D in monkeys; a clinical and pathologic study. (13498130)
1958
36
Experimental hypervitaminosis D: hypercalcemia, hypermucoproteinemia, and metastatic calcification. (13408285)
1957
37
Calcified scleral nodules in hypervitaminosis D. (14361626)
1955
38
Dentine dysplasia associated with rheumatoid arthritis and hypervitaminosis D. (13224191)
1955
39
Comparative study of the reaction to injury. II. Hypervitaminosis D in the frog with special reference to the lime sacs. (13064930)
1953
40
Hypervitaminosis D due to ertron. (13077422)
1953
41
Resistant rickets? incomplete fanconi syndrome; bilateral femoral supracondylar osteotomy; hypervitaminosis D. (14864530)
1951
42
JOINT FAO/WHO expert committee on nutrition, 1951, Rome; hypervitaminosis D. (14905272)
1951
43
Hypervitaminosis D; report of nine cases. (18909525)
1948
44
Metastatic calcification produced in dogs by hypervitaminosis D and haliphagia. (18859354)
1948
45
Chronic moderate hypervitaminosis D in young dogs. (20239960)
1947
46
Metastatic Calcification Associated with Hypervitaminosis D and Haliphagia. (19970911)
1946
47
The solar irradiation of children with special reference to hypervitaminosis D. (21031954)
1934
48
The mode of action of vitamin D: Studies on hypervitaminosis D. The influence of the calcium-phosphate intake. (16744588)
1931
49
The Pathology of Hypovitaminosis and Hypervitaminosis D and its Application to an Explanation of the Mode of Action of the Vitamin. (19988301)
1931
50
The phosphorus distribution in blood and the calcium and phosphorus excretion during hypervitaminosis D. (16744406)
1930

Genetic Variations for Hypervitaminosis D

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Expression for genes affiliated with Hypervitaminosis D

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypervitaminosis D

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Pathways for genes affiliated with Hypervitaminosis D

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37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Hypervitaminosis D according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGF23, PTH
29.6TRPV6, TRPV5
3
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.5PTH, VDR
4
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9.5KL, FGF23
5
Hide members
9.5FGF23, KL
69.4CYP27B1, VDR
79.3VDR, TRPV6
8
Vitamin D2 (ergocalciferol) metabolism
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9.1PTH, CYP27B1, VDR
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.1VDR, CYP27B1, PTH
109.0VDR, TRPV5, KL

Compounds for genes affiliated with Hypervitaminosis D

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59Tocris Bioscience, 28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1amg 9810599.9TRPV5, TRPV6
25-iodoresiniferatoxin59 2810.9TRPV5, TRPV6
3hc 067047599.9TRPV5, TRPV6
4estrogen449.9VDR
5doxercalciferol449.8VDR, PTH
6ruthenium red289.8TRPV5, TRPV6
7capsazepine44 59 2811.8TRPV5, TRPV6
8Calcidiol11 2410.8VDR, CYP27B1
9mg2+289.8TRPV6, TRPV5
10calcifediol599.8VDR, CYP27B1
11gemini449.8VDR, CYP27B1
12Ergocalciferol11 2410.7CYP27B1, VDR
13alfacalcidol44 59 1111.7VDR, CYP27B1
1424,25-dihydroxyvitamin d3449.7VDR, CYP27B1
15calcipotriol44 59 28 1112.6VDR, CYP27B1
16deoxypyridinoline449.6PTH, VDR
17eb 108944 5910.6CYP27B1, VDR
18alendronate44 49 1111.6VDR, PTH
19anandamide44 28 59 2412.5TRPV6, TRPV5
20paricalcitol44 1110.4VDR, CYP27B1, PTH
21pge2449.1PTH, CYP27B1, VDR
2225-hydroxyvitamin d449.0VDR, CYP27B1, FGF23, PTH
23phosphorus448.9PTH, FGF23, CYP27B1, VDR
24estradiol44 11 2410.6STC2, CYP27B1, PTH
25calcitriol44 59 11 2411.4TRPV6, VDR, CYP27B1, FGF23, PTH
261,25 dihydroxy vitamin d3448.1PTH, FGF23, CYP27B1, VDR, TRPV6, TRPV5
27vitamin d448.1TRPV5, TRPV6, VDR, CYP27B1, FGF23, PTH
28calcium44 49 11 249.8KL, STC2, TRPV5, TRPV6, VDR, CYP27B1

GO Terms for genes affiliated with Hypervitaminosis D

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16Gene Ontology
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Biological processes related to Hypervitaminosis D according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:0423699.7FGF23, CYP27B1
2positive regulation of bone mineralizationGO:0305019.7PTH, KL
3positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:0900809.6FGF23, KL
4positive regulation of keratinocyte differentiationGO:0456189.4CYP27B1, VDR
5calcium ion homeostasisGO:0550749.3CYP27B1, KL
6response to vitamin DGO:0332809.1STC2, CYP27B1
7positive regulation of vitamin D 24-hydroxylase activityGO:0109809.1FGF23, CYP27B1, VDR
8cellular calcium ion homeostasisGO:0068748.8STC2, VDR, PTH
9decidualizationGO:0466978.8CYP27B1, VDR, STC2
10calcium ion transportGO:0068168.7TRPV5, TRPV6, VDR, CYP27B1

Molecular functions related to Hypervitaminosis D according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:0052629.6TRPV6, TRPV5
2hormone activityGO:0051798.6PTH, STC2, KL

Products for genes affiliated with Hypervitaminosis D

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  • Antibodies
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Sources for Hypervitaminosis D

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet