MCID: HYP189
MIFTS: 46

Hypoadrenalism malady

Endocrine category

Summaries for Hypoadrenalism

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

MalaCards: Hypoadrenalism, also known as adrenal gland hypofunction, is related to diabetes insipidus and sheehan syndrome. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Glycoprotein hormones. The drugs cortisone and dehydroepiandrosterone and the compounds acth and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, adrenal gland and skin, and related mouse phenotypes are adipose tissue and cardiovascular system.

Aliases & Classifications for Hypoadrenalism

Sources:
61UMLS, 43NIH Rare Diseases, 45Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

hypoadrenalism 43 45
adrenal gland hypofunction 61


Related Diseases for Hypoadrenalism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.1POMC
2sheehan syndrome29.9CRH, POMC
3panhypopituitarism29.9POMC, GH1
4hepatitis c29.9CYP1A2
5hypercalcemia29.9PTHLH, CALCA
6cushing's syndrome29.9CALCA, CRH, GH1, POMC
7amenorrhea29.9CRH, INS, POMC, SHBG
8addison's disease29.9PCSK1, TG, CRH, POMC
9waterhouse-friderichsen syndrome10.3
10polymyalgia rheumatica10.3
11tuberculosis10.2
12pulmonary tuberculosis10.1
13rheumatoid arthritis10.0CRH
14fibromyalgia10.0CRH
15pituitary apoplexy10.0POMC
16gastrinoma10.0GH1
17lung cancer10.0POMC
18fibrous dysplasia10.0GH1
19nephrotic syndrome10.0POMC
20empty sella syndrome10.0POMC
21hypoaldosteronism10.0POMC
22neurogenic diabetes insipidus10.0POMC
23marasmus10.0GH1
24obesity with impaired prohormone processing10.0PCSK1
25hepatitis10.0CYP1A2
26adrenal carcinoma10.0POMC
27seasonal affective disorder10.0CRH
28uremia10.0GH1
29laron syndrome10.0GH1
30vipoma10.0GH1
31liver cirrhosis10.0CYP1A2
32blindness10.0INS
33multiple sclerosis10.0POMC
34myocardial infarction10.0SHBG
35morbid obesity10.0INS
36eating disorder10.0INS
37pancreatitis10.0INS
38acne10.0SHBG
39diabetic ketoacidosis10.0INS
40endogenous depression10.0CRH, POMC
41fatty liver disease10.0INS
42hepatoblastoma10.0SHBG
43klinefelter's syndrome10.0SHBG
44rabson-mendenhall syndrome10.0INS
45chronic fatigue syndrome10.0CRH, POMC
46craniopharyngioma10.0POMC, GH1
47adrenal adenoma10.0CRH, POMC
48lactic acidosis10.0INS
49mental retardation10.0SHBG
50colorectal cancer10.0CYP1A2

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Clinical Features for Hypoadrenalism

Drugs & Therapeutics for Hypoadrenalism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypoadrenalism:

33
Brain, Adrenal gland, Skin, Pituitary

Animal Models for Hypoadrenalism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypoadrenalism

Sources:
51PubMed
See all sources

Articles related to Hypoadrenalism:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
2
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
3
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. (21986010)
2011
4
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
5
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
6
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. (20016446)
2009
7
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
8
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
9
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
10
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. (17888053)
2007
11
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. (16414105)
2006
12
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
13
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
14
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
15
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (10931104)
2000
16
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. (10984555)
2000
17
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
18
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
19
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
20
Diagnosis of secondary hypoadrenalism. (8796149)
1996
21
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
22
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
23
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
24
Occult hypoadrenalism in critically ill patients. (8154974)
1994
25
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
26
Hypoadrenalism, Addison's disease and antiphospholipid antibodies. (2023176)
1991
27
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
28
Hypoadrenalism in patients with pulmonary tuberculosis in Tanzania: an undiagnosed complication? (2096522)
1990
29
Perinatal hypoadrenalism in the rat does not alter glucose tolerance and insulin secretory response to glucose. (2075642)
1990
30
Primary hypoadrenalism in a patient with the lupus anticoagulant. (2123934)
1990
31
Partially compensated hypoadrenalism presenting with persistent skin pigmentation. (2542390)
1989
32
Co-existent hypoadrenalism in an asymptomatic patient with multiple trauma. (3362086)
1988
33
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
34
Methadone induced hypoadrenalism. (6128489)
1982
35
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
36
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
37
Hypoadrenalism. (4335574)
1972
38
Specific activity and sensitivity of strophanthin of the Na + +K + -activated ATPase in rats and guinea-pigs with hypoadrenalism. (4262726)
1972
39
Differential diagnosis of the month: hypoadrenalism. (5834310)
1965
40
Absence of pituitary gland, hypothyroidism, hypoadrenalism and hypogonadism in a 17-year-old dwarf. (4284833)
1965
41
TREATMENT OF HYPOADRENALISM. (14060931)
1963
42
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
43
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
44
The effects of hypoadrenalism and chronic inanition on the development of the rudimentary gonad in sinistrally ovariectomized fowl; development of fowls' right gonad. (13394935)
1956
45
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
46
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
47
The administration of purified growth hormone to a female with hypoadrenalism, hypothyroidism, diabetes mellitus, and secondary amenorrhea, simulating panhypopituitarism. (14938425)
1952
48
Hypoadrenalism in newborn infants; a case report. (14861449)
1951
49
Hypoadrenalism: steroidal mediation of sodium action on blood pressure; modification of antiarthritic response to cortisone. (14797749)
1950
50
11-Dehydrocorticosterone; its effects on hypoadrenalism in man. (20993798)
1946

Genetic Variations for Hypoadrenalism

Expression for genes affiliated with Hypoadrenalism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

Sources:
50PharmGKB, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Hypoadrenalism

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1acth4510.0CRH, POMC, GH1
2estrogen459.9PCSK1, TG
3forskolin45 50 1111.7CALCA, POMC, CRH
4bromocriptine29 45 1111.7SHBG, CYP1A2, POMC
5dopamine45 29 11 2412.7CYP1A2, SHBG, CRH
6hexarelin45 2910.6CRH, POMC, GH1
711 deoxycortisol459.6POMC, SHBG, CRH
8allopregnanolone459.6POMC, SHBG, CRH
9atropine45 29 1111.5GH1, CALCA, CYP1A2
10dehydroepiandrosterone sulfate459.5GH1, POMC, SHBG, CRH
11mirtazapine50 45 1111.5POMC, CYP1A2, CRH
12ketoconazole45 29 11 2412.4CYP1A2, SHBG, CRH, POMC
13carbamazepine45 50 1111.4CRH, CYP1A2, POMC, SHBG
14anastrozole45 1110.3GH1, CYP1A2, SHBG
15norepinephrine45 11 2411.3CYP1A2, CALCA, POMC, PTHLH
16clonidine45 29 1111.3GH1, CALCA, POMC, CYP1A2
17oxandrolone45 1110.2SHBG, INS, GH1
18propranolol45 29 50 11 2413.2GH1, CRH, CALCA, CYP1A2
19cortisone45 2410.2INS, POMC, GH1, CRH
20i-app459.0INS, CALCA, PCSK1
21clomiphene citrate459.0SHBG, INS, CRH, GH1
22triiodothyronine459.0GH1, SHBG, TG, POMC
23metformin45 50 1110.8INS, POMC, SHBG, GH1
24c-peptide458.8SHBG, GH1, PCSK1, INS
25prednisolone45 29 1110.8POMC, SHBG, PTHLH, TG, GH1
26indomethacin45 60 29 1111.8PTHLH, POMC, GH1, CALCA, CRH
27corticosterone45 60 2410.8GH1, CRH, POMC, CALCA
28dhea458.7GH1, POMC, SHBG, CRH, INS
29estradiol45 11 2410.7PTHLH, CYP1A2, CRH, GH1, POMC, SHBG
30glycerol45 11 2410.6CRH, SHBG, GH1, POMC, INS
31ribonucleic acid458.6PCSK1, TG, CRH, GH1, POMC, PTHLH
32rosiglitazone45 50 29 11 2412.5INS, CYP1A2, SHBG, GH1, PTHLH
33calcitriol45 60 11 2411.4TG, PTHLH, SHBG, GH1, CALCA
34ibmx45 29 6010.4GH1, PCSK1, INS, PTHLH, CALCA
35acetylcholine45 50 29 11 2412.4CALCA, CRH, PTHLH, TG, POMC, GH1
36vitamin d458.4CRH, PTHLH, SHBG, GH1, CALCA
37progesterone45 60 29 11 2412.4PTHLH, CYP1A2, PCSK1, POMC, GH1, CRH
38gnrh458.4INS, GH1, PCSK1, POMC, CRH, SHBG
39androstenedione45 249.4CYP1A2, POMC, INS, SHBG, CRH, GH1
40dexamethasone45 50 29 1110.9GH1, PTHLH, INS, SHBG, POMC, CRH
41lactate457.7CALCA, GH1, INS, PTHLH, TG, SHBG
42adenylate457.6CRH, PTHLH, CALCA, TG, PCSK1, POMC
43octreotide45 60 29 1110.6INS, GH1, CALCA, CRH, POMC, TG
44alanine457.6GH1, SHBG, CRH, PTHLH, TG, INS
45arginine457.3PCSK1, CRH, GH1, SHBG, TG, POMC
46epinephrine45 11 249.2GH1, SHBG, CALCA, POMC, TG, INS
47hydrocortisone45 2 60 1110.2TG, PTHLH, INS, POMC, SHBG, GH1
48thyroxine45 248.2INS, PTHLH, TG, CALCA, POMC, SHBG
49creatinine457.2POMC, INS, TG, CALCA, CRH, GH1
50testosterone45 60 11 249.8CYP1A2, PTHLH, CALCA, TG, INS, POMC

GO Terms for genes affiliated with Hypoadrenalism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.0INS, PCSK1, POMC
2extracellular spaceGO:0056156.8PTHLH, CALCA, CRH, GH1, POMC, PCSK1
3extracellular regionGO:0055766.4TG, CALCA, PTHLH, INS, POMC, SHBG

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.9POMC, PCSK1
2response to painGO:0482659.7CRH, CALCA
3feeding behaviorGO:0076319.7CRH, CALCA
4negative regulation of blood pressureGO:0457769.6CRH, CALCA
5positive regulation of cAMP biosynthetic processGO:0308199.4CALCA, CRH, PTHLH
6positive regulation of vasodilationGO:0459098.8INS, CALCA
7cell-cell signalingGO:0072678.2PTHLH, INS, PCSK1, POMC, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051797.2TG, PTHLH, INS, POMC, GH1, CRH

Products for genes affiliated with Hypoadrenalism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypoadrenalism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet