MCID: HYP189
MIFTS: 40

Hypoadrenalism malady

Endocrine diseases category

Summaries for Hypoadrenalism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

MalaCards: Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypothyroidism and hypopituitarism. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Glycoprotein hormones. The drugs cortisone and dehydroepiandrosterone and the compounds acth and estrogen have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, and related mouse phenotypes are adipose tissue and cardiovascular system.

Aliases & Classifications for Hypoadrenalism

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60UMLS, 42NIH Rare Diseases, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypoadrenalism 42 44
adrenal gland hypofunction 60


Related Diseases for Hypoadrenalism

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17GeneCards, 18GeneDecks
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Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.2SHBG, TG
2hypopituitarism30.2CRH, POMC, GH1, INS, SHBG
3diabetes insipidus30.1POMC
4addison's disease30.1PCSK1, TG, CRH, POMC
5hypogonadism30.0CALCA, CRH, GH1, SHBG, POMC, INS
6hepatitis29.9CYP1A2
7panhypopituitarism29.9POMC, GH1
8hepatitis c29.9CYP1A2
9hypercalcemia29.8PTHLH, CALCA
10cushing's syndrome29.8CALCA, CRH, GH1, POMC
11amenorrhea29.8CRH, INS, POMC, SHBG
12diabetes mellitus29.8SHBG, POMC, GH1, CALCA, INS
13hyperthyroidism29.8PCSK1, INS, TG, GH1, SHBG
14waterhouse-friderichsen syndrome10.2
15polymyalgia rheumatica10.2
16tuberculosis10.2
17pulmonary tuberculosis10.1
18rheumatoid arthritis10.0CRH
19fibromyalgia10.0CRH
20pituitary apoplexy10.0POMC
21gastrinoma10.0GH1
22lung cancer10.0POMC
23fibrous dysplasia10.0GH1
24nephrotic syndrome10.0POMC
25empty sella syndrome10.0POMC
26hypoaldosteronism10.0POMC
27neurogenic diabetes insipidus10.0POMC
28marasmus10.0GH1
29obesity with impaired prohormone processing10.0PCSK1
30adrenal carcinoma10.0POMC
31seasonal affective disorder10.0CRH
32uremia10.0GH1
33laron syndrome10.0GH1
34vipoma10.0GH1
35liver cirrhosis10.0CYP1A2
36blindness10.0INS
37myocardial infarction10.0SHBG
38morbid obesity10.0INS
39multiple sclerosis10.0POMC
40eating disorder10.0INS
41pancreatitis10.0INS
42acne10.0SHBG
43diabetic ketoacidosis10.0INS
44endogenous depression10.0CRH, POMC
45fatty liver disease10.0INS
46hepatoblastoma10.0SHBG
47klinefelter's syndrome10.0SHBG
48sheehan syndrome10.0CRH, POMC
49chronic fatigue syndrome10.0CRH, POMC
50rabson-mendenhall syndrome10.0INS

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Clinical Features for Hypoadrenalism

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Drugs & Therapeutics for Hypoadrenalism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypoadrenalism

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Anatomical Context for Hypoadrenalism

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32MalaCards
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MalaCards organs/tissues related to Hypoadrenalism:

32
Adrenal gland

Animal Models for Hypoadrenalism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypoadrenalism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3GH1, POMC, PCSK1, INS, PTHLH
2MP:00053857.7PTHLH, INS, CYP1A2, PCSK1, POMC, CALCA
3MP:00053977.2CRH, POMC, PCSK1, CYP1A2, INS, PTHLH
4MP:00053797.2TG, CRH, GH1, POMC, PCSK1, CYP1A2
5MP:00053867.0CALCA, CRH, POMC, MYH1, PCSK1, CYP1A2
6MP:00053786.9CRH, GH1, POMC, MYH1, PCSK1, INS
7MP:00036316.9CALCA, CRH, GH1, POMC, INS, PTHLH
8MP:00053766.6CALCA, CRH, GH1, POMC, PCSK1, CYP1A2

Publications for Hypoadrenalism

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Genetic Variations for Hypoadrenalism

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Expression for genes affiliated with Hypoadrenalism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

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49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Hypoadrenalism

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1acth4410.0CRH, POMC, GH1
2estrogen449.9PCSK1, TG
3forskolin44 49 1111.7CALCA, POMC, CRH
4bromocriptine28 44 1111.7SHBG, CYP1A2, POMC
5dopamine44 28 11 2412.7CYP1A2, SHBG, CRH
6hexarelin44 2810.6CRH, POMC, GH1
711 deoxycortisol449.6POMC, SHBG, CRH
8allopregnanolone449.6POMC, SHBG, CRH
9atropine44 28 1111.5GH1, CALCA, CYP1A2
10dehydroepiandrosterone sulfate449.5GH1, POMC, SHBG, CRH
11mirtazapine49 44 1111.5POMC, CYP1A2, CRH
12ketoconazole44 28 11 2412.4CYP1A2, SHBG, CRH, POMC
13carbamazepine44 49 1111.4CRH, CYP1A2, POMC, SHBG
14anastrozole44 1110.3GH1, CYP1A2, SHBG
15norepinephrine44 11 2411.3CYP1A2, CALCA, POMC, PTHLH
16clonidine44 28 1111.3GH1, CALCA, POMC, CYP1A2
17oxandrolone44 1110.2SHBG, INS, GH1
18propranolol44 28 49 11 2413.2GH1, CRH, CALCA, CYP1A2
19cortisone44 2410.2INS, POMC, GH1, CRH
20i-app449.0INS, CALCA, PCSK1
21clomiphene citrate449.0SHBG, INS, CRH, GH1
22triiodothyronine449.0GH1, SHBG, TG, POMC
23metformin44 49 1110.8INS, POMC, SHBG, GH1
24c-peptide448.8SHBG, GH1, PCSK1, INS
25prednisolone44 28 1110.8POMC, SHBG, PTHLH, TG, GH1
26indomethacin44 59 28 1111.8PTHLH, POMC, GH1, CALCA, CRH
27corticosterone44 59 2410.8GH1, CRH, POMC, CALCA
28dhea448.7GH1, POMC, SHBG, CRH, INS
29estradiol44 11 2410.7PTHLH, CYP1A2, CRH, GH1, POMC, SHBG
30glycerol44 11 2410.6CRH, SHBG, GH1, POMC, INS
31ribonucleic acid448.6PCSK1, TG, CRH, GH1, POMC, PTHLH
32rosiglitazone44 49 28 11 2412.5INS, CYP1A2, SHBG, GH1, PTHLH
33calcitriol44 59 11 2411.4TG, PTHLH, SHBG, GH1, CALCA
34ibmx44 28 5910.4GH1, PCSK1, INS, PTHLH, CALCA
35acetylcholine44 49 28 11 2412.4CALCA, CRH, PTHLH, TG, POMC, GH1
36vitamin d448.4CRH, PTHLH, SHBG, GH1, CALCA
37progesterone44 59 28 11 2412.4PTHLH, CYP1A2, PCSK1, POMC, GH1, CRH
38gnrh448.4INS, GH1, PCSK1, POMC, CRH, SHBG
39androstenedione44 249.4CYP1A2, POMC, INS, SHBG, CRH, GH1
40dexamethasone44 49 28 1110.9GH1, PTHLH, INS, SHBG, POMC, CRH
41lactate447.7CALCA, GH1, INS, PTHLH, TG, SHBG
42adenylate447.6CRH, PTHLH, CALCA, TG, PCSK1, POMC
43octreotide44 59 28 1110.6INS, GH1, CALCA, CRH, POMC, TG
44alanine447.6GH1, SHBG, CRH, PTHLH, TG, INS
45arginine447.3PCSK1, CRH, GH1, SHBG, TG, POMC
46epinephrine44 11 249.2GH1, SHBG, CALCA, POMC, TG, INS
47hydrocortisone44 2 59 1110.2TG, PTHLH, INS, POMC, SHBG, GH1
48thyroxine44 248.2INS, PTHLH, TG, CALCA, POMC, SHBG
49creatinine447.2POMC, INS, TG, CALCA, CRH, GH1
50testosterone44 59 11 249.8CYP1A2, PTHLH, CALCA, TG, INS, POMC

GO Terms for genes affiliated with Hypoadrenalism

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16Gene Ontology
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Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.0INS, PCSK1, POMC
2extracellular spaceGO:0056156.8TG, CALCA, CRH, GH1, POMC, PCSK1
3extracellular regionGO:0055766.4CALCA, CRH, GH1, SHBG, POMC, INS

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8POMC, PCSK1
2response to painGO:0482659.7CALCA, CRH
3feeding behaviorGO:0076319.7CRH, CALCA
4negative regulation of blood pressureGO:0457769.6CRH, CALCA
5positive regulation of cAMP biosynthetic processGO:0308199.4CALCA, CRH, PTHLH
6positive regulation of vasodilationGO:0459098.8INS, CALCA
7cell-cell signalingGO:0072678.2PTHLH, INS, PCSK1, POMC, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051797.2TG, PTHLH, INS, POMC, GH1, CRH

Products for genes affiliated with Hypoadrenalism

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  • Antibodies
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Sources for Hypoadrenalism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet