MCID: HYP189
MIFTS: 37

Hypoadrenalism malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoadrenalism

Aliases & Descriptions for Hypoadrenalism:

Name: Hypoadrenalism 50 52
Adrenal Gland Hypofunction 69
Hypoaldosteronism 69

Classifications:



Summaries for Hypoadrenalism

MalaCards based summary : Hypoadrenalism, also known as adrenal gland hypofunction, is related to addison's disease and obesity with impaired prohormone processing. An important gene associated with Hypoadrenalism is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Neuroscience and Presynaptic function of Kainate receptors. The drugs Dexamethasone and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related phenotype is endocrine/exocrine gland.

Related Diseases for Hypoadrenalism

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
id Related Disease Score Top Affiliating Genes
1 addison's disease 11.1
2 obesity with impaired prohormone processing 10.9
3 achalasia-addisonianism-alacrimia syndrome 10.8
4 breast secretory carcinoma 10.3 CRH POMC
5 nonparalytic poliomyelitis 10.3 CRH POMC
6 dacryoadenitis 10.3 CRH POMC
7 early-onset parkinson disease 10.3 CRH POMC
8 femur bifid with monodactylous ectrodactyly 10.3 CRH POMC
9 malignant otitis externa 10.2 CRH POMC
10 thyrotoxic exophthalmos 10.2 POMC TG
11 autoimmune disease of endocrine system 10.2 CRH POMC
12 traumatic glaucoma 10.2 CRH POMC
13 guillain-barre syndrome 10.2 POMC TG
14 basal ganglia cerebrovascular disease 10.2 POMC SHBG
15 eccrine papillary adenocarcinoma 10.2 POMC PTHLH
16 macrocephaly, benign familial 10.2 GH1 POMC
17 congenital tricuspid stenosis 10.2 GH1 POMC
18 dyt1 early-onset isolated dystonia 10.2 CYP1A2 POMC
19 merkel cell carcinoma 10.2 CRH POMC
20 sphingolipidosis 10.2 POMC SHBG
21 esophagus squamous cell papilloma 10.2 CRH POMC
22 olfactory nerve neoplasm 10.2 GH1 POMC
23 acute laryngitis 10.2 POMC TG
24 tick paralysis 10.2 SHBG TG
25 protein s deficiency 10.2 GH1 POMC
26 strabismus 10.2 PTHLH TG
27 mixed eosinophil-basophil adenoma 10.2 SHBG TG
28 pulmonary neuroendocrine tumor 10.2 GH1 POMC
29 male genital organ stricture 10.2 GH1 SHBG
30 capillary disease 10.2 POMC SHBG
31 gonococcal seminal vesiculitis 10.2 CALCA POMC
32 waardenburg syndrome, type 4b 10.1 CALCA PTHLH
33 astroblastoma 10.1 CRH POMC SHBG
34 maroteaux stanescu cousin syndrome 10.1 CALCA PTHLH
35 acute gonococcal salpingitis 10.1 CRH POMC SHBG
36 endophthalmitis 10.1 CALCA TG
37 gastrinoma 10.1 CALCA TG
38 corneal ectasia 10.1 CALCA TG
39 superior vena cava angiosarcoma 10.1 CALCA TG
40 krabbe disease 10.1 CALCA TG
41 immune system organ benign neoplasm 10.1 CRH POMC TG
42 perineural angioma 10.1 CALCA TG
43 body dysmorphic disorder 10.1 POMC PTHLH SHBG
44 keloids 10.1 CALCA PTHLH
45 diencephalic neoplasm 10.1 GH1 POMC
46 childhood optic tract astrocytoma 10.1 CRH POMC
47 chronic eosinophilic pneumonia 10.1 CALCA CRH
48 intermittent squint 10.1 CRH GH1 POMC
49 childhood vagina botryoid rhabdomyosarcoma 10.1 CALCA TG
50 rheumatic encephalitis 10.1 GH1 POMC

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to Hypoadrenalism

Symptoms & Phenotypes for Hypoadrenalism

MGI Mouse Phenotypes related to Hypoadrenalism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CRH CYP1A2 PCSK1 POMC PTHLH TG

Drugs & Therapeutics for Hypoadrenalism

Drugs for Hypoadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
4
Fludrocortisone Approved Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
5
Cortisone acetate Approved Phase 4 1950-04-4, 50-04-4 5745
6
Cosyntropin Approved Phase 4 16960-16-0 16129617
7
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
8
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
13
Etomidate Approved Phase 4,Phase 2,Phase 3 33125-97-2 36339 667484
14
Menthol Approved Phase 4 2216-51-5 16666
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
16
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
17
Xylometazoline Approved Phase 4 526-36-3 5709
18
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
19
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
20 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
21
Butyric Acid Experimental Phase 4,Phase 2,Phase 3,Phase 1 107-92-6 264
22
Cortisone Phase 4 53-06-5 222786
23 Dexamethasone acetate Phase 4,Phase 1 1177-87-3
24 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
25 Mydriatics Phase 4,Phase 3,Phase 2,Phase 1
26 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
29 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Adrenocorticotropic Hormone Phase 4,Phase 1
32 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1
33 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
34 Dexamethasone 21-phosphate Phase 4,Phase 1
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
38 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1
40 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1
41 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1
42 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1
43 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
44 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Racepinephrine Phase 4,Phase 2,Phase 3,Phase 1
47 Liver Extracts Phase 4,Phase 3,Phase 2
48 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
49 BB 1101 Phase 4,Phase 1
50 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 152)
id Name Status NCT ID Phase
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4
2 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Unknown status NCT02277587 Phase 4
3 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4
4 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4
5 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4
6 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4
7 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4
8 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4
9 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4
10 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4
12 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4
13 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4
14 Salt Loading and Thiazide Intervention Study Completed NCT00896389 Phase 4
15 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
16 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4
17 Corticosteroid Reduction in COPD Recruiting NCT02857842 Phase 4
18 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4
19 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Active, not recruiting NCT02206256 Phase 4
20 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4
21 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Not yet recruiting NCT02997605 Phase 4
22 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4
23 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4
24 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4
25 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4
26 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4
27 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3
28 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3
29 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3
30 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3
31 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3
32 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3
33 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3
34 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3
35 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3
36 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3
37 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3
38 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3
39 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3
40 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3
41 Extension Study for Patients Entered Into Study Infacort 003 Recruiting NCT02733367 Phase 3
42 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Recruiting NCT02700828 Phase 2, Phase 3
43 A Phase 2/3 Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Recruiting NCT01896102 Phase 2, Phase 3
44 MD1003-AMN MD1003 in Adrenomyeloneuropathy Active, not recruiting NCT02961803 Phase 2, Phase 3
45 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Enrolling by invitation NCT02105415 Phase 2, Phase 3
46 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
47 Effect of Glycerol Trierucate on Clinical Course of Adrenoleukodystrophy Suspended NCT00004418 Phase 2, Phase 3
48 A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy Terminated NCT00545597 Phase 3
49 Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock Withdrawn NCT02069288 Phase 3
50 Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function Unknown status NCT00657306 Phase 2

Search NIH Clinical Center for Hypoadrenalism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

MalaCards organs/tissues related to Hypoadrenalism:

39
Adrenal Gland, Testes, Pituitary, Skin, Brain, Skeletal Muscle

Publications for Hypoadrenalism

Articles related to Hypoadrenalism:

(show top 50) (show all 88)
id Title Authors Year
1
Hypoadrenalism secondary to topical corticosteroid-containing skin-lightening cream: danger of over-the-counter cosmetic agents. ( 26424061 )
2015
2
A Case of Autoimmune Polyglandular Syndrome (APS) Type II with Hypothyroidism, Hypoadrenalism, and Celiac Disease - A Rare Combination. ( 26023582 )
2015
3
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
4
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. ( 24615601 )
2014
5
Central hypoadrenalism. ( 25140404 )
2014
6
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. ( 23729816 )
2013
7
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. ( 23365166 )
2013
8
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. ( 22998100 )
2013
9
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. ( 22402482 )
2012
10
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? ( 23422765 )
2012
11
Hypoadrenalism presenting as a range of mental disorders. ( 22707626 )
2011
12
Painful hypoadrenalism. ( 22700071 )
2011
13
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. ( 21986010 )
2011
14
Clinical Review#: The diagnosis and management of central hypoadrenalism. ( 20719838 )
2010
15
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement. ( 19131388 )
2009
16
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. ( 20016446 )
2009
17
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? ( 19266139 )
2009
18
Secondary hypoadrenalism. ( 18418713 )
2008
19
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. ( 18990320 )
2008
20
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. ( 18801174 )
2008
21
Hypoadrenalism following trauma: is sepsis always necessary? ( 19079677 )
2008
22
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. ( 18704214 )
2008
23
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. ( 18284838 )
2008
24
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. ( 17888053 )
2007
25
Doses and steroids to be used in primary and central hypoadrenalism. ( 17651687 )
2007
26
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. ( 16414105 )
2006
27
Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? ( 16914596 )
2006
28
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. ( 16218046 )
2005
29
Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. ( 15734854 )
2005
30
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. ( 16508710 )
2005
31
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. ( 15636426 )
2004
32
CHARGE association and secondary hypoadrenalism. ( 12567418 )
2003
33
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. ( 14635559 )
2003
34
Cerebral salt wasting syndrome or secondary hypoadrenalism? ( 11433653 )
2001
35
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 10931104 )
2000
36
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. ( 10984555 )
2000
37
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 11155100 )
2000
38
The role of the low dose ACTH test in the evaluation of central hypoadrenalism. ( 10435862 )
1999
39
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. ( 9522797 )
1998
40
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. ( 10395233 )
1998
41
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. ( 9894388 )
1998
42
Transient hypoadrenalism during surgical critical illness. ( 9484735 )
1998
43
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9274709 )
1997
44
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9373445 )
1997
45
Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. ( 8849565 )
1996
46
Diagnosis of secondary hypoadrenalism. ( 8796149 )
1996
47
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. ( 8822324 )
1995
48
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. ( 8736284 )
1995
49
Secondary hypoadrenalism presenting with hypercalcaemia. ( 7923833 )
1994
50
Secondary hypoadrenalism with hypercalcaemia. ( 7889623 )
1994

Variations for Hypoadrenalism

Expression for Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for Hypoadrenalism

GO Terms for Hypoadrenalism

Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CALCA CRH GH1 PCSK1 POMC PTHLH
2 extracellular region GO:0005576 9.17 CALCA CRH GH1 POMC PTHLH SHBG

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.4 CALCA PTHLH
2 negative regulation of blood pressure GO:0045776 9.37 CALCA CRH
3 response to immobilization stress GO:0035902 9.32 CRH CYP1A2
4 peptide hormone processing GO:0016486 9.26 PCSK1 POMC
5 cell-cell signaling GO:0007267 9.26 CALCA PCSK1 POMC PTHLH
6 response to pain GO:0048265 9.16 CALCA CRH
7 positive regulation of cAMP biosynthetic process GO:0030819 8.8 CALCA CRH PTHLH

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 CALCA CRH GH1 POMC PTHLH TG

Sources for Hypoadrenalism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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