MCID: HYP189
MIFTS: 46

Hypoadrenalism malady

Rare diseases, Endocrine diseases categories

Summaries for Hypoadrenalism

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MalaCards based summary: Hypoadrenalism, also known as adrenal gland hypofunction, is related to cushing's syndrome and hypothyroidism. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Endochondral Ossification. The drugs triamcinolone and triamcinolone acetonide and the compounds hexarelin and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Hypoadrenalism

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Hypoadrenalism, Aliases & Descriptions:

Name: Hypoadrenalism 41 43
 
Adrenal Gland Hypofunction 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Hypoadrenalism

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Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.7CRH, POMC
2hypothyroidism30.6TG, SHBG
3amenorrhea30.2SHBG, POMC, CRH
4hypopituitarism30.2SHBG, POMC, GH1, CRH
5addison's disease30.1TG, POMC, PCSK1, CRH
6hypercalcemia29.9PTHLH, CALCA
7hyperthyroidism29.7SHBG, TG, GH1, PCSK1
8hypogonadism29.3SHBG, POMC, GH1, PCSK1, CALCA, CRH
9pituitary apoplexy10.5POMC
10major depressive disorder and accelerated response to antidepressant drug treatment10.5CRH
11adrenal carcinoma10.5POMC
12pituitary carcinoma10.5POMC
13marasmus10.5GH1
14vipoma10.5GH1
15endogenous depression10.4CRH, POMC
16sheehan syndrome10.4POMC, CRH
17nelson syndrome10.4POMC, CRH
18melancholia10.4POMC, CRH
19west syndrome10.4POMC, CRH
20hypothalamic disease10.4GH1, CRH
21chronic fatigue syndrome10.4POMC, CRH
22adrenal adenoma10.3POMC, CRH
23pituitary hormone deficiency, combined, 210.3POMC, GH1
24craniopharyngioma10.3POMC, GH1
25congenital adrenal hyperplasia10.3POMC, CRH
26panic disorder10.3CRH, POMC
27adrenocortical carcinoma10.3CRH, POMC
28adrenal cortical adenoma10.3POMC, CRH
29glucagonoma10.3GH1, PCSK1
30leydig cell tumor10.2PTHLH, POMC
31dwarfism10.2GH1, PTHLH
32pituitary-dependent cushing's disease10.2POMC, GH1, CRH
33gonadal disease10.2POMC, GH1, CRH
34tuberculosis10.2
35pituitary gland disease10.2POMC, GH1, CRH
36adrenal gland hyperfunction10.2CRH, GH1, POMC
37prostatic hypertrophy10.2GH1, SHBG
38growth hormone deficiency10.2CRH, GH1, POMC
39hypoglycemia10.2CRH, GH1, POMC
40polycystic ovary syndrome10.2GH1, SHBG
41plummer's disease10.2TG, SHBG
42mood disorder10.2CRH, POMC
43thyroid hormone resistance10.2TG, SHBG
44nutritional deficiency disease10.2CYP1A2, GH1
45prolactinoma10.2GH1, POMC, PTHLH
46hyperinsulinism10.2SHBG, GH1
47idiopathic juvenile osteoporosis10.1GH1, CALCA
48hypothryoidism, congenital, nongoitrous 410.1TG, POMC, GH1
49pulmonary tuberculosis10.1
50diabetes insipidus10.1

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Symptoms for Hypoadrenalism

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Genetic Tests for Hypoadrenalism

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Anatomical Context for Hypoadrenalism

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MalaCards organs/tissues related to Hypoadrenalism:

31
Adrenal gland, Testes, Pituitary, Brain, Skin, Skeletal muscle

Animal Models for Hypoadrenalism or affiliated genes

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MGI Mouse Phenotypes related to Hypoadrenalism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PTHLH, POMC, GH1, PCSK1
2MP:00053888.5CRH, CALCA, PTHLH, CYP1A2
3MP:00053978.0CYP1A2, PTHLH, TG, POMC, PCSK1, CRH
4MP:00053787.8PTHLH, TG, POMC, GH1, PCSK1, CRH
5MP:00053797.7CRH, CYP1A2, PTHLH, TG, POMC, GH1
6MP:00053867.7CYP1A2, PTHLH, POMC, PCSK1, CALCA, CRH
7MP:00036317.6PTHLH, TG, POMC, GH1, CALCA, CRH
8MP:00053857.6CYP1A2, PTHLH, POMC, PCSK1, CALCA
9MP:00053766.9CYP1A2, PTHLH, TG, POMC, GH1, PCSK1

Publications for Hypoadrenalism

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Articles related to Hypoadrenalism:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Central hypoadrenalism. (25140404)
2014
2
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. (24615601)
2014
3
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. (22998100)
2013
4
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
5
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
6
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
7
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. (22402482)
2012
8
Painful hypoadrenalism. (22700071)
2011
9
Hypoadrenalism presenting as a range of mental disorders. (22707626)
2011
10
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
11
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
12
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
13
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)
2008
14
Secondary hypoadrenalism. (18418713)
2008
15
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
16
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
17
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
18
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
19
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
20
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
21
CHARGE association and secondary hypoadrenalism. (12567418)
2003
22
Cerebral salt wasting syndrome or secondary hypoadrenalism? (11433653)
2001
23
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (11155100)
2000
24
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)
1998
25
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. (9522797)
1998
26
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
27
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
28
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
29
Diagnosis of secondary hypoadrenalism. (8796149)
1996
30
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
31
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
32
Secondary hypoadrenalism presenting with hypercalcaemia. (7923833)
1994
33
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
34
Occult hypoadrenalism in critically ill patients. (8154974)
1994
35
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
36
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
37
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
38
Non-Hodgkin's lymphoma as a cause of hypoadrenalism. (3328977)
1987
39
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
40
Methadone-induced hypoadrenalism. (6132074)
1983
41
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
42
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
43
Sebum excretion and melanocyte-stimulating hormone in hypoadrenalism. (4854211)
1974
44
DIAGNOSIS AND MANAGEMENT OF HYPOADRENALISM. (14067669)
1963
45
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
46
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
47
The effects of hypoadrenalism and chronic inanition on the development of the rudimentary gonad in sinistrally ovariectomized fowl; development of fowls' right gonad. (13394935)
1956
48
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
49
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
50
Hypoadrenalism in newborn infants; a case report. (14861449)
1951

Variations for Hypoadrenalism

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Expression for genes affiliated with Hypoadrenalism

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Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

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Pathways related to Hypoadrenalism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
29.6GH1, PTHLH
3
Show member pathways
9.4CRH, GH1, POMC
4
Show member pathways
9.2POMC, GH1, PCSK1
5
Show member pathways
8.5PTHLH, POMC, CALCA, CRH
68.5CRH, CALCA, POMC, PTHLH
7
Show member pathways
8.2CRH, CALCA, GH1, POMC, PTHLH
8
Show member pathways
8.2PTHLH, POMC, GH1, CALCA, CRH

Compounds for genes affiliated with Hypoadrenalism

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Compounds related to Hypoadrenalism according to GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1hexarelin43 2810.7CRH, POMC, GH1
2betamethasone43 1210.7CRH, POMC, GH1
3mirtazapine43 49 1211.6CRH, POMC, CYP1A2
411 deoxycortisol439.5CRH, SHBG, POMC
5allopregnanolone439.5POMC, CRH, SHBG
6sertraline43 28 49 24 1213.4POMC, CYP1A2, CRH
7anastrozole43 49 1211.3SHBG, GH1, CYP1A2
8clomiphene citrate439.2CRH, SHBG, GH1
9dehydroepiandrosterone sulfate439.2CRH, GH1, SHBG, POMC
10ketoconazole43 28 24 1212.2POMC, CRH, SHBG, CYP1A2
11dhea439.2SHBG, POMC, GH1, CRH
12carbamazepine43 49 1211.1CRH, POMC, SHBG, CYP1A2
13verapamil43 28 49 24 1213.1GH1, PTHLH, CRH, CYP1A2
14naltrexone43 28 49 1212.1POMC, GH1, CRH
15bromocriptine43 28 1211.1CYP1A2, SHBG, POMC, GH1
16nifedipine43 28 49 1212.1CYP1A2, PTHLH, CRH, GH1
17ether43 4910.0CRH, POMC, CALCA
18triiodothyronine438.9SHBG, TG, GH1, POMC
19atropine43 28 1210.9CRH, CALCA, GH1, CYP1A2
20corticosterone43 59 2410.9POMC, GH1, CALCA, CRH
21clonidine43 49 28 1211.9GH1, POMC, CYP1A2, CALCA
22propranolol43 28 49 24 1212.9GH1, CYP1A2, CALCA, CRH
23androstenedione43 249.8SHBG, POMC, GH1, CRH, CYP1A2
24rosiglitazone28 43 49 24 1212.8CYP1A2, GH1, PTHLH, SHBG
25gnrh438.7SHBG, POMC, GH1, PCSK1, CRH
26prednisolone43 28 1210.6GH1, POMC, TG, PTHLH, SHBG
27indomethacin43 28 59 1211.5PTHLH, POMC, GH1, CALCA, CRH
28ribonucleic acid438.4PTHLH, CRH, PCSK1, GH1, POMC, TG
29estradiol43 24 1210.4SHBG, POMC, CYP1A2, PTHLH, CRH, GH1
30dexamethasone43 49 28 1211.3CYP1A2, PTHLH, GH1, CRH, POMC, SHBG
31vitamin d438.2SHBG, CALCA, PTHLH, CRH, GH1
32ibmx43 59 2810.2GH1, CALCA, PTHLH, PCSK1
33alanine438.1TG, PTHLH, GH1, CRH, SHBG, POMC
34octreotide43 59 28 1211.1PTHLH, TG, POMC, GH1, CALCA, CRH
35calcitriol43 59 24 1211.1CALCA, TG, GH1, SHBG, PTHLH
36acetylcholine43 49 28 24 1212.1PTHLH, CALCA, CRH, TG, POMC, GH1
37forskolin43 49 1210.0PCSK1, PTHLH, POMC, CRH, GH1, CALCA
38dopamine43 28 24 1211.0SHBG, CYP1A2, CALCA, CRH, POMC, GH1
39acth437.9GH1, PCSK1, CALCA, CRH, SHBG, POMC
40progesterone43 28 59 24 1211.9PCSK1, SHBG, PTHLH, POMC, GH1, CRH
41lactate437.8SHBG, PTHLH, TG, GH1, CALCA
42arginine437.7CRH, GH1, POMC, PCSK1, TG, PTHLH
43epinephrine43 24 129.5CYP1A2, CRH, TG, CALCA, GH1, POMC
44hydrocortisone43 2 59 1210.5PTHLH, TG, POMC, GH1, CALCA, CRH
45thyroxine43 248.5CRH, POMC, CALCA, GH1, PTHLH, SHBG
46creatinine437.4GH1, CRH, POMC, TG, CALCA, PTHLH
47norepinephrine43 24 129.1PTHLH, CYP1A2, SHBG, TG, POMC, GH1
48testosterone43 59 24 1210.0PTHLH, SHBG, TG, POMC, GH1, CRH
49adenylate436.9POMC, SHBG, TG, CRH, CALCA, PCSK1
50estrogen436.5CALCA, PCSK1, GH1, POMC, TG, CRH

GO Terms for genes affiliated with Hypoadrenalism

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Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.6PCSK1, POMC
2extracellular spaceGO:00056157.0CRH, PTHLH, TG, POMC, GH1, PCSK1
3extracellular regionGO:00055766.7SHBG, PTHLH, TG, POMC, GH1, CALCA

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.7POMC, PCSK1
2response to painGO:00482659.5CRH, CALCA
3negative regulation of blood pressureGO:00457769.4CRH, CALCA
4feeding behaviorGO:00076319.3CRH, CALCA
5regulation of gene expressionGO:00104689.3PTHLH, CYP1A2
6regulation of blood pressureGO:00082179.3CALCA, POMC
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.1PTHLH, CALCA
8positive regulation of cAMP biosynthetic processGO:00308199.1CRH, CALCA, PTHLH
9cell-cell signalingGO:00072678.5PTHLH, POMC, PCSK1, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.0CRH, CALCA, POMC
2hormone activityGO:00051797.3CRH, CALCA, GH1, POMC, TG, PTHLH

Products for genes affiliated with Hypoadrenalism

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Sources for Hypoadrenalism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet