MCID: HYP189
MIFTS: 52

Hypoadrenalism malady

Rare diseases, Endocrine diseases categories
Download this MalaCard

Summaries for Hypoadrenalism

About this section


Fully expand this MalaCard
Wikipedia:65 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

MalaCards based summary: Hypoadrenalism, also known as adrenal gland hypofunction, is related to cushing's syndrome and hypothyroidism. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Endochondral Ossification. The drugs cortisone and dehydroepiandrosterone and the compounds hexarelin and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Hypoadrenalism

About this section
Sources:
62UMLS, 42NIH Rare Diseases, 44Novoseek
See all sources

Hypoadrenalism, Aliases & Descriptions:

Name: Hypoadrenalism 42 44
 
Adrenal Gland Hypofunction 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Hypoadrenalism

About this section

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.7POMC, CRH
2hypothyroidism30.5SHBG, TG
3panhypopituitarism30.5POMC, GH1
4hypopituitarism30.3GH1, SHBG, CRH, POMC
5addison's disease30.2CRH, PCSK1, POMC, TG
6amenorrhea30.1POMC, SHBG, CRH
7hypercalcemia29.9PTHLH, CALCA
8hyperthyroidism29.7PCSK1, SHBG, TG, GH1
9diabetes mellitus29.6CALCA, GH1, POMC, SHBG
10hypogonadism29.3GH1, PCSK1, POMC, CALCA, CRH, SHBG
11pituitary apoplexy10.5POMC
12seasonal affective disorder10.5CRH
13adrenal carcinoma10.5POMC
14pituitary carcinoma10.5POMC
15marasmus10.5GH1
16vipoma10.5GH1
17endogenous depression10.4POMC, CRH
18sheehan syndrome10.4POMC, CRH
19nelson syndrome10.4CRH, POMC
20melancholia10.4POMC, CRH
21infantile epileptic encephalopathy10.4POMC, CRH
22hypothalamic disease10.4CRH, GH1
23chronic fatigue syndrome10.4CRH, POMC
24adrenal adenoma10.4CRH, POMC
25craniopharyngioma10.3POMC, GH1
26congenital adrenal hyperplasia10.3CRH, POMC
27panic disorder10.3POMC, CRH
28adrenocortical carcinoma10.3POMC, CRH
29adrenal cortical adenoma10.3POMC, CRH
30glucagonoma10.3PCSK1, GH1
31leydig cell tumor10.2PTHLH, POMC
32dwarfism10.2PTHLH, GH1
33acth-secreting pituitary adenoma10.2POMC, CRH, GH1
34gonadal disease10.2POMC, GH1, CRH
35pituitary gland disease10.2POMC, CRH, GH1
36adrenal gland hyperfunction10.2POMC, CRH, GH1
37growth hormone deficiency10.2POMC, CRH, GH1
38tuberculosis10.2
39hypoglycemia10.2CRH, GH1, POMC
40polycystic ovary syndrome10.2GH1, SHBG
41mood disorder10.2CRH, POMC
42plummer's disease10.2SHBG, TG
43thyroid hormone resistance syndrome10.2SHBG, TG
44prolactinoma10.2PTHLH, POMC, GH1
45hyperinsulinism10.2GH1, SHBG
46thyrotropin deficiency, isolated10.1TG, GH1, POMC
47idiopathic juvenile osteoporosis10.1GH1, CALCA
48pulmonary tuberculosis10.1
49diabetes insipidus10.1
50neuroendocrine tumor10.1CALCA, POMC

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Symptoms for Hypoadrenalism

About this section

Genetic Tests for Hypoadrenalism

About this section

Anatomical Context for Hypoadrenalism

About this section

MalaCards organs/tissues related to Hypoadrenalism:

32
Adrenal gland, Testes, Pituitary, Brain, Skeletal muscle

Animal Models for Hypoadrenalism or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypoadrenalism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PTHLH, POMC, GH1, PCSK1
2MP:00053888.5CRH, CALCA, PTHLH, CYP1A2
3MP:00053978.0CYP1A2, PTHLH, TG, POMC, PCSK1, CRH
4MP:00053787.8PTHLH, TG, POMC, GH1, PCSK1, CRH
5MP:00053797.7CRH, CYP1A2, PTHLH, TG, POMC, GH1
6MP:00053867.7CYP1A2, PTHLH, POMC, PCSK1, CALCA, CRH
7MP:00036317.6PTHLH, TG, POMC, GH1, CALCA, CRH
8MP:00053857.6CYP1A2, PTHLH, POMC, PCSK1, CALCA
9MP:00053766.9CYP1A2, PTHLH, TG, POMC, GH1, PCSK1

Publications for Hypoadrenalism

About this section

Articles related to Hypoadrenalism:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Central hypoadrenalism. (25140404)
2014
2
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. (24615601)
2014
3
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. (22998100)
2013
4
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
5
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
6
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
7
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. (22402482)
2012
8
Painful hypoadrenalism. (22700071)
2011
9
Hypoadrenalism presenting as a range of mental disorders. (22707626)
2011
10
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
11
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
12
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
13
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)
2008
14
Secondary hypoadrenalism. (18418713)
2008
15
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
16
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
17
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
18
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
19
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
20
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
21
CHARGE association and secondary hypoadrenalism. (12567418)
2003
22
Cerebral salt wasting syndrome or secondary hypoadrenalism? (11433653)
2001
23
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (11155100)
2000
24
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)
1998
25
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. (9522797)
1998
26
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
27
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
28
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
29
Diagnosis of secondary hypoadrenalism. (8796149)
1996
30
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
31
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
32
Secondary hypoadrenalism presenting with hypercalcaemia. (7923833)
1994
33
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
34
Occult hypoadrenalism in critically ill patients. (8154974)
1994
35
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
36
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
37
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
38
Non-Hodgkin's lymphoma as a cause of hypoadrenalism. (3328977)
1987
39
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
40
Methadone-induced hypoadrenalism. (6132074)
1983
41
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
42
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
43
Sebum excretion and melanocyte-stimulating hormone in hypoadrenalism. (4854211)
1974
44
Differential diagnosis of the month: hypoadrenalism. (5834310)
1965
45
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
46
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
47
The effects of hypoadrenalism and chronic inanition on the development of the rudimentary gonad in sinistrally ovariectomized fowl; development of fowls' right gonad. (13394935)
1956
48
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
49
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
50
Hypoadrenalism in newborn infants; a case report. (14861449)
1951

Variations for Hypoadrenalism

About this section

Expression for genes affiliated with Hypoadrenalism

About this section
Expression patterns in normal tissues for genes affiliated with Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

About this section

Pathways related to Hypoadrenalism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
29.6GH1, PTHLH
39.6CRH, PCSK1
4
Show member pathways
9.4CRH, GH1, POMC
5
Show member pathways
9.2POMC, GH1, PCSK1
6
Show member pathways
8.5PTHLH, POMC, CALCA, CRH
78.5CRH, CALCA, POMC, PTHLH
8
Show member pathways
8.2CRH, CALCA, GH1, POMC, PTHLH
9
Show member pathways
8.2PTHLH, POMC, GH1, CALCA, CRH

Compounds for genes affiliated with Hypoadrenalism

About this section

Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1hexarelin44 2810.7CRH, POMC, GH1
2betamethasone44 1110.7CRH, POMC, GH1
3mirtazapine44 50 1111.6CRH, POMC, CYP1A2
411 deoxycortisol449.5CRH, SHBG, POMC
5allopregnanolone449.5POMC, CRH, SHBG
6sertraline44 28 50 24 1113.4POMC, CYP1A2, CRH
7anastrozole44 50 1111.3SHBG, GH1, CYP1A2
8clomiphene citrate449.2CRH, SHBG, GH1
9dehydroepiandrosterone sulfate449.2CRH, GH1, SHBG, POMC
10ketoconazole44 28 24 1112.2POMC, CRH, SHBG, CYP1A2
11dhea449.2SHBG, POMC, GH1, CRH
12carbamazepine44 50 1111.1CRH, POMC, SHBG, CYP1A2
13verapamil44 28 50 24 1113.1GH1, PTHLH, CRH, CYP1A2
14naltrexone44 28 50 1112.1POMC, GH1, CRH
15bromocriptine44 28 1111.1CYP1A2, SHBG, POMC, GH1
16nifedipine44 28 50 1112.1CYP1A2, PTHLH, CRH, GH1
17ether44 5010.0CRH, POMC, CALCA
18triiodothyronine448.9SHBG, TG, GH1, POMC
19atropine44 28 1110.9CRH, CALCA, GH1, CYP1A2
20corticosterone44 61 2410.9POMC, GH1, CALCA, CRH
21clonidine44 50 28 1111.9GH1, POMC, CYP1A2, CALCA
22propranolol44 28 50 24 1112.9GH1, CYP1A2, CALCA, CRH
23androstenedione44 249.8SHBG, POMC, GH1, CRH, CYP1A2
24rosiglitazone28 44 50 24 1112.8CYP1A2, GH1, PTHLH, SHBG
25gnrh448.7SHBG, POMC, GH1, PCSK1, CRH
26prednisolone44 28 1110.6GH1, POMC, TG, PTHLH, SHBG
27indomethacin44 28 61 1111.5PTHLH, POMC, GH1, CALCA, CRH
28ribonucleic acid448.4PTHLH, CRH, PCSK1, GH1, POMC, TG
29estradiol44 24 1110.4SHBG, POMC, CYP1A2, PTHLH, CRH, GH1
30dexamethasone44 50 28 1111.3CYP1A2, PTHLH, GH1, CRH, POMC, SHBG
31vitamin d448.2SHBG, CALCA, PTHLH, CRH, GH1
32ibmx44 61 2810.2GH1, CALCA, PTHLH, PCSK1
33alanine448.1TG, PTHLH, GH1, CRH, SHBG, POMC
34octreotide44 61 28 1111.1PTHLH, TG, POMC, GH1, CALCA, CRH
35calcitriol44 61 24 1111.1CALCA, TG, GH1, SHBG, PTHLH
36acetylcholine44 50 28 24 1112.1PTHLH, CALCA, CRH, TG, POMC, GH1
37forskolin44 50 1110.0PCSK1, PTHLH, POMC, CRH, GH1, CALCA
38dopamine44 28 24 1111.0SHBG, CYP1A2, CALCA, CRH, POMC, GH1
39acth447.9GH1, PCSK1, CALCA, CRH, SHBG, POMC
40progesterone44 28 61 24 1111.9PCSK1, SHBG, PTHLH, POMC, GH1, CRH
41lactate447.8SHBG, PTHLH, TG, GH1, CALCA
42arginine447.7CRH, GH1, POMC, PCSK1, TG, PTHLH
43epinephrine44 24 119.5CYP1A2, CRH, TG, CALCA, GH1, POMC
44hydrocortisone44 2 61 1110.5PTHLH, TG, POMC, GH1, CALCA, CRH
45thyroxine44 248.5CRH, POMC, CALCA, GH1, PTHLH, SHBG
46creatinine447.4GH1, CRH, POMC, TG, CALCA, PTHLH
47norepinephrine44 24 119.1PTHLH, CYP1A2, SHBG, TG, POMC, GH1
48testosterone44 61 24 1110.0PTHLH, SHBG, TG, POMC, GH1, CRH
49adenylate446.9POMC, SHBG, TG, CRH, CALCA, PCSK1
50estrogen446.5CALCA, PCSK1, GH1, POMC, TG, CRH

GO Terms for genes affiliated with Hypoadrenalism

About this section

Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6PCSK1, POMC
2extracellular spaceGO:0056157.0CRH, PTHLH, TG, POMC, GH1, PCSK1
3extracellular regionGO:0055766.7SHBG, PTHLH, TG, POMC, GH1, CALCA

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.7POMC, PCSK1
2response to painGO:0482659.5CRH, CALCA
3negative regulation of blood pressureGO:0457769.4CRH, CALCA
4feeding behaviorGO:0076319.3CRH, CALCA
5regulation of gene expressionGO:0104689.3PTHLH, CYP1A2
6regulation of blood pressureGO:0082179.3CALCA, POMC
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.1PTHLH, CALCA
8positive regulation of cAMP biosynthetic processGO:0308199.1CRH, CALCA, PTHLH
9cell-cell signalingGO:0072678.5PTHLH, POMC, PCSK1, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.0CRH, CALCA, POMC
2hormone activityGO:0051797.3CRH, CALCA, GH1, POMC, TG, PTHLH

Products for genes affiliated with Hypoadrenalism

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hypoadrenalism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet