MCID: HYP189
MIFTS: 52

Hypoadrenalism malady

Rare diseases, Endocrine diseases categories

Summaries for Hypoadrenalism

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66Wikipedia, 34MalaCards
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Wikipedia:66 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

MalaCards: Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypothyroidism and hypopituitarism. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Endochondral Ossification. The drugs cortisone and dehydroepiandrosterone and the compounds hexarelin and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Hypoadrenalism

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63UMLS, 44NIH Rare Diseases, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypoadrenalism 44 46
adrenal gland hypofunction 63


Related Diseases for Hypoadrenalism

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18GeneCards, 19GeneDecks
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Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.3SHBG, TG
2hypopituitarism30.3GH1, SHBG, CRH, POMC
3addison's disease30.1CRH, PCSK1, POMC, TG
4panhypopituitarism30.1POMC, GH1
5cushing's syndrome30.1POMC, CRH
6amenorrhea30.0POMC, SHBG, CRH
7hypogonadism29.9GH1, PCSK1, POMC, CALCA, CRH, SHBG
8hypercalcemia29.9PTHLH, CALCA
9hyperthyroidism29.9PCSK1, SHBG, TG, GH1
10diabetes mellitus29.8CALCA, GH1, POMC, SHBG
11tuberculosis10.2
12pituitary apoplexy10.1POMC
13seasonal affective disorder10.1CRH
14adrenal carcinoma10.1POMC
15pituitary carcinoma10.1POMC
16marasmus10.1GH1
17vipoma10.1GH1
18pulmonary tuberculosis10.1
19diabetes insipidus10.1
20endogenous depression10.1POMC, CRH
21sheehan syndrome10.1POMC, CRH
22nelson syndrome10.1CRH, POMC
23melancholia10.1POMC, CRH
24infantile epileptic encephalopathy10.1POMC, CRH
25hypothalamic disease10.1CRH, GH1
26chronic fatigue syndrome10.1CRH, POMC
27craniopharyngioma10.1POMC, GH1
28congenital adrenal hyperplasia10.1CRH, POMC
29panic disorder10.1POMC, CRH
30adrenocortical carcinoma10.1POMC, CRH
31adrenal adenoma10.1POMC, CRH
32glucagonoma10.1PCSK1, GH1
33leydig cell tumor10.1PTHLH, POMC
34dwarfism10.1PTHLH, GH1
35acth-secreting pituitary adenoma10.1POMC, CRH, GH1
36gonadal disease10.1POMC, GH1, CRH
37pituitary gland disease10.1POMC, CRH, GH1
38adrenal gland hyperfunction10.1POMC, CRH, GH1
39growth hormone deficiency10.1POMC, CRH, GH1
40hypoglycemia10.0CRH, GH1, POMC
41polycystic ovary syndrome10.0GH1, SHBG
42mood disorder10.0CRH, POMC
43plummer's disease10.0SHBG, TG
44thyroid hormone resistance syndrome10.0SHBG, TG
45prolactinoma10.0PTHLH, POMC, GH1
46hyperinsulinism10.0GH1, SHBG
47thyrotropin deficiency, isolated10.0TG, GH1, POMC
48idiopathic juvenile osteoporosis10.0GH1, CALCA
49neuroendocrine tumor10.0CALCA, POMC
50thyroid adenoma10.0TG, SHBG

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Symptoms for Hypoadrenalism

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Genetic Tests for Hypoadrenalism

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Anatomical Context for Hypoadrenalism

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34MalaCards
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MalaCards organs/tissues related to Hypoadrenalism:

34
Adrenal gland, Testes, Pituitary, Brain, Skin, Skeletal muscle

Animal Models for Hypoadrenalism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypoadrenalism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PTHLH, POMC, GH1, PCSK1
2MP:00053888.5CRH, CALCA, PTHLH, CYP1A2
3MP:00053978.0CYP1A2, PTHLH, TG, POMC, PCSK1, CRH
4MP:00053787.8PTHLH, TG, POMC, GH1, PCSK1, CRH
5MP:00053797.7CRH, CYP1A2, PTHLH, TG, POMC, GH1
6MP:00053867.7CYP1A2, PTHLH, POMC, PCSK1, CALCA, CRH
7MP:00036317.6PTHLH, TG, POMC, GH1, CALCA, CRH
8MP:00053857.6CYP1A2, PTHLH, POMC, PCSK1, CALCA
9MP:00053766.9CYP1A2, PTHLH, TG, POMC, GH1, PCSK1

Publications for Hypoadrenalism

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53PubMed
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Articles related to Hypoadrenalism:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. (22998100)
2013
2
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
3
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
4
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
5
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. (22402482)
2012
6
Painful hypoadrenalism. (22700071)
2011
7
Hypoadrenalism presenting as a range of mental disorders. (22707626)
2011
8
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
9
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
10
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
11
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)
2008
12
Secondary hypoadrenalism. (18418713)
2008
13
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
14
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
15
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
16
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
17
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
18
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
19
CHARGE association and secondary hypoadrenalism. (12567418)
2003
20
Cerebral salt wasting syndrome or secondary hypoadrenalism? (11433653)
2001
21
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (11155100)
2000
22
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)
1998
23
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. (9522797)
1998
24
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
25
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
26
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
27
Diagnosis of secondary hypoadrenalism. (8796149)
1996
28
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
29
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
30
Secondary hypoadrenalism presenting with hypercalcaemia. (7923833)
1994
31
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
32
Occult hypoadrenalism in critically ill patients. (8154974)
1994
33
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
34
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
35
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
36
Non-Hodgkin's lymphoma as a cause of hypoadrenalism. (3328977)
1987
37
Acute hypoadrenalism and hepatotoxicity after treatment with ketoconazole. (2881126)
1987
38
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
39
Methadone-induced hypoadrenalism. (6132074)
1983
40
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
41
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
42
Sebum excretion and melanocyte-stimulating hormone in hypoadrenalism. (4854211)
1974
43
Differential diagnosis of the month: hypoadrenalism. (5834310)
1965
44
DIAGNOSIS AND MANAGEMENT OF HYPOADRENALISM. (14067669)
1963
45
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
46
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
47
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
48
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
49
Sodium-retaining corticoid in the urine of normal children and adults and of patients with hypoadrenalism or hypopituitarism. (13192179)
1954
50
Hypoadrenalism in newborn infants; a case report. (14861449)
1951

Variations for Hypoadrenalism

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Expression for genes affiliated with Hypoadrenalism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 13EMD Millipore, 54QIAGEN, 56Reactome, 61Thomson Reuters, 31KEGG
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Pathways related to Hypoadrenalism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
29.6GH1, PTHLH
39.6CRH, PCSK1
4
Show member pathways
9.4CRH, GH1, POMC
5
Show member pathways
9.2POMC, GH1, PCSK1
6
Show member pathways
8.5PTHLH, POMC, CALCA, CRH
78.5CRH, CALCA, POMC, PTHLH
8
Show member pathways
8.2CRH, CALCA, GH1, POMC, PTHLH
9
Show member pathways
8.2PTHLH, POMC, GH1, CALCA, CRH

Compounds for genes affiliated with Hypoadrenalism

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1hexarelin46 3010.7CRH, POMC, GH1
2betamethasone46 1210.7CRH, POMC, GH1
3mirtazapine46 52 1211.6CRH, POMC, CYP1A2
411 deoxycortisol469.5CRH, SHBG, POMC
5allopregnanolone469.5POMC, CRH, SHBG
6sertraline46 30 52 25 1213.4POMC, CYP1A2, CRH
7anastrozole46 52 1211.3SHBG, GH1, CYP1A2
8clomiphene citrate469.2CRH, SHBG, GH1
9dehydroepiandrosterone sulfate469.2CRH, GH1, SHBG, POMC
10ketoconazole46 30 25 1212.2POMC, CRH, SHBG, CYP1A2
11dhea469.2SHBG, POMC, GH1, CRH
12carbamazepine46 52 1211.1CRH, POMC, SHBG, CYP1A2
13verapamil46 30 52 25 1213.1GH1, PTHLH, CRH, CYP1A2
14naltrexone46 30 52 1212.1POMC, GH1, CRH
15bromocriptine46 30 1211.1CYP1A2, SHBG, POMC, GH1
16nifedipine46 30 52 1212.1CYP1A2, PTHLH, CRH, GH1
17ether46 5210.0CRH, POMC, CALCA
18triiodothyronine468.9SHBG, TG, GH1, POMC
19atropine46 30 1210.9CRH, CALCA, GH1, CYP1A2
20corticosterone46 62 2510.9POMC, GH1, CALCA, CRH
21clonidine46 52 30 1211.9GH1, POMC, CYP1A2, CALCA
22propranolol46 30 52 25 1212.9GH1, CYP1A2, CALCA, CRH
23androstenedione46 259.8SHBG, POMC, GH1, CRH, CYP1A2
24rosiglitazone30 46 52 25 1212.8CYP1A2, GH1, PTHLH, SHBG
25gnrh468.7SHBG, POMC, GH1, PCSK1, CRH
26prednisolone46 30 1210.6GH1, POMC, TG, PTHLH, SHBG
27indomethacin46 30 62 1211.5PTHLH, POMC, GH1, CALCA, CRH
28ribonucleic acid468.4PTHLH, CRH, PCSK1, GH1, POMC, TG
29estradiol46 25 1210.4SHBG, POMC, CYP1A2, PTHLH, CRH, GH1
30dexamethasone46 52 30 1211.3CYP1A2, PTHLH, GH1, CRH, POMC, SHBG
31vitamin d468.2SHBG, CALCA, PTHLH, CRH, GH1
32ibmx46 62 3010.2GH1, CALCA, PTHLH, PCSK1
33alanine468.1TG, PTHLH, GH1, CRH, SHBG, POMC
34octreotide46 62 30 1211.1PTHLH, TG, POMC, GH1, CALCA, CRH
35calcitriol46 62 25 1211.1CALCA, TG, GH1, SHBG, PTHLH
36acetylcholine46 52 30 25 1212.1PTHLH, CALCA, CRH, TG, POMC, GH1
37forskolin46 52 1210.0PCSK1, PTHLH, POMC, CRH, GH1, CALCA
38dopamine46 30 25 1211.0SHBG, CYP1A2, CALCA, CRH, POMC, GH1
39acth467.9GH1, PCSK1, CALCA, CRH, SHBG, POMC
40progesterone46 30 62 25 1211.9PCSK1, SHBG, PTHLH, POMC, GH1, CRH
41lactate467.8SHBG, PTHLH, TG, GH1, CALCA
42arginine467.7CRH, GH1, POMC, PCSK1, TG, PTHLH
43epinephrine46 25 129.5CYP1A2, CRH, TG, CALCA, GH1, POMC
44hydrocortisone46 3 62 1210.5PTHLH, TG, POMC, GH1, CALCA, CRH
45thyroxine46 258.5CRH, POMC, CALCA, GH1, PTHLH, SHBG
46creatinine467.4GH1, CRH, POMC, TG, CALCA, PTHLH
47norepinephrine46 25 129.1PTHLH, CYP1A2, SHBG, TG, POMC, GH1
48testosterone46 62 25 1210.0PTHLH, SHBG, TG, POMC, GH1, CRH
49adenylate466.9POMC, SHBG, TG, CRH, CALCA, PCSK1
50estrogen466.5CALCA, PCSK1, GH1, POMC, TG, CRH

GO Terms for genes affiliated with Hypoadrenalism

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17Gene Ontology
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Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6PCSK1, POMC
2extracellular spaceGO:0056157.0CALCA, PTHLH, TG, POMC, GH1, PCSK1
3extracellular regionGO:0055766.7CRH, SHBG, PTHLH, TG, POMC, GH1

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.7POMC, PCSK1
2response to painGO:0482659.5CRH, CALCA
3negative regulation of blood pressureGO:0457769.4CRH, CALCA
4feeding behaviorGO:0076319.3CRH, CALCA
5regulation of gene expressionGO:0104689.3PTHLH, CYP1A2
6regulation of blood pressureGO:0082179.3CALCA, POMC
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.1PTHLH, CALCA
8positive regulation of cAMP biosynthetic processGO:0308199.1CRH, CALCA, PTHLH
9cell-cell signalingGO:0072678.5PTHLH, POMC, PCSK1, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.0CRH, CALCA, POMC
2hormone activityGO:0051797.3CRH, CALCA, GH1, POMC, TG, PTHLH

Products for genes affiliated with Hypoadrenalism

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  • Antibodies
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Sources for Hypoadrenalism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet