MCID: HYP189
MIFTS: 51

Hypoadrenalism malady

Rare diseases, Endocrine diseases categories

Summaries for Hypoadrenalism

About this section


MalaCards based summary: Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypothyroidism and addison's disease. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Endochondral Ossification. The drugs cortisone and dehydroepiandrosterone and the compounds hexarelin and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Hypoadrenalism

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Hypoadrenalism, Aliases & Descriptions:

Name: Hypoadrenalism 43 45
 
Adrenal Gland Hypofunction 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Hypoadrenalism

About this section

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.4SHBG, TG
2addison's disease30.3CRH, PCSK1, POMC, TG
3cushing's syndrome30.3POMC, CRH
4hypopituitarism30.2GH1, SHBG, CRH, POMC
5hypogonadism30.1GH1, PCSK1, POMC, CALCA, CRH, SHBG
6amenorrhea30.0POMC, SHBG, CRH
7hypercalcemia30.0PTHLH, CALCA
8hyperthyroidism29.9PCSK1, SHBG, TG, GH1
9tuberculosis10.2
10pulmonary tuberculosis10.1
11diabetes insipidus10.1
12pituitary apoplexy10.1POMC
13major depressive disorder and accelerated response to antidepressant drug treatment10.1CRH
14adrenal carcinoma10.1POMC
15pituitary carcinoma10.1POMC
16marasmus10.1GH1
17vipoma10.1GH1
18endogenous depression10.0POMC, CRH
19sheehan syndrome10.0POMC, CRH
20nelson syndrome10.0CRH, POMC
21melancholia10.0POMC, CRH
22west syndrome10.0POMC, CRH
23hypothalamic disease10.0CRH, GH1
24chronic fatigue syndrome10.0CRH, POMC
25adrenal adenoma10.0CRH, POMC
26pituitary hormone deficiency, combined, 210.0POMC, GH1
27craniopharyngioma10.0POMC, GH1
28congenital adrenal hyperplasia10.0CRH, POMC
29panic disorder10.0POMC, CRH
30adrenocortical carcinoma10.0POMC, CRH
31adrenal cortical adenoma10.0POMC, CRH
32glucagonoma10.0PCSK1, GH1
33leydig cell tumor10.0PTHLH, POMC
34dwarfism10.0PTHLH, GH1
35pituitary-dependent cushing's disease10.0POMC, CRH, GH1
36gonadal disease10.0POMC, GH1, CRH
37pituitary gland disease10.0POMC, CRH, GH1
38adrenal gland hyperfunction10.0POMC, CRH, GH1
39growth hormone deficiency10.0POMC, CRH, GH1
40hypoglycemia10.0CRH, GH1, POMC
41polycystic ovary syndrome10.0GH1, SHBG
42mood disorder10.0CRH, POMC
43plummer's disease10.0SHBG, TG
44thyroid hormone resistance10.0SHBG, TG
45prolactinoma10.0PTHLH, POMC, GH1
46hyperinsulinism10.0GH1, SHBG
47hypothryoidism, congenital, nongoitrous 410.0TG, GH1, POMC
48idiopathic juvenile osteoporosis10.0GH1, CALCA
49neuroendocrine tumor10.0CALCA, POMC
50thyroid adenoma10.0TG, SHBG

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Symptoms for Hypoadrenalism

About this section

Genetic Tests for Hypoadrenalism

About this section

Anatomical Context for Hypoadrenalism

About this section

MalaCards organs/tissues related to Hypoadrenalism:

33
Adrenal gland, Testes, Pituitary, Brain, Skin, Skeletal muscle

Animal Models for Hypoadrenalism or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypoadrenalism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PTHLH, POMC, GH1, PCSK1
2MP:00053888.5CRH, CALCA, PTHLH, CYP1A2
3MP:00053978.0CYP1A2, PTHLH, TG, POMC, PCSK1, CRH
4MP:00053787.8PTHLH, TG, POMC, GH1, PCSK1, CRH
5MP:00053797.7CRH, CYP1A2, PTHLH, TG, POMC, GH1
6MP:00053867.7CYP1A2, PTHLH, POMC, PCSK1, CALCA, CRH
7MP:00036317.6PTHLH, TG, POMC, GH1, CALCA, CRH
8MP:00053857.6CYP1A2, PTHLH, POMC, PCSK1, CALCA
9MP:00053766.9CYP1A2, PTHLH, TG, POMC, GH1, PCSK1

Publications for Hypoadrenalism

About this section

Articles related to Hypoadrenalism:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Central hypoadrenalism. (25140404)
2014
2
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. (24615601)
2014
3
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. (22998100)
2013
4
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
5
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
6
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
7
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. (22402482)
2012
8
Painful hypoadrenalism. (22700071)
2011
9
Hypoadrenalism presenting as a range of mental disorders. (22707626)
2011
10
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
11
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
12
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
13
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)
2008
14
Secondary hypoadrenalism. (18418713)
2008
15
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
16
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
17
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
18
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
19
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
20
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
21
CHARGE association and secondary hypoadrenalism. (12567418)
2003
22
Cerebral salt wasting syndrome or secondary hypoadrenalism? (11433653)
2001
23
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (11155100)
2000
24
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)
1998
25
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. (9522797)
1998
26
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
27
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
28
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
29
Diagnosis of secondary hypoadrenalism. (8796149)
1996
30
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
31
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
32
Secondary hypoadrenalism presenting with hypercalcaemia. (7923833)
1994
33
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
34
Occult hypoadrenalism in critically ill patients. (8154974)
1994
35
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
36
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
37
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
38
Non-Hodgkin's lymphoma as a cause of hypoadrenalism. (3328977)
1987
39
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
40
Methadone-induced hypoadrenalism. (6132074)
1983
41
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
42
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
43
Sebum excretion and melanocyte-stimulating hormone in hypoadrenalism. (4854211)
1974
44
DIAGNOSIS AND MANAGEMENT OF HYPOADRENALISM. (14067669)
1963
45
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
46
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
47
The effects of hypoadrenalism and chronic inanition on the development of the rudimentary gonad in sinistrally ovariectomized fowl; development of fowls' right gonad. (13394935)
1956
48
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
49
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
50
Hypoadrenalism in newborn infants; a case report. (14861449)
1951

Variations for Hypoadrenalism

About this section

Expression for genes affiliated with Hypoadrenalism

About this section

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

About this section

Pathways related to Hypoadrenalism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
29.6GH1, PTHLH
39.6CRH, PCSK1
4
Show member pathways
9.4CRH, GH1, POMC
5
Show member pathways
9.2POMC, GH1, PCSK1
6
Show member pathways
8.5PTHLH, POMC, CALCA, CRH
78.5CRH, CALCA, POMC, PTHLH
8
Show member pathways
8.2CRH, CALCA, GH1, POMC, PTHLH
9
Show member pathways
8.2PTHLH, POMC, GH1, CALCA, CRH

Compounds for genes affiliated with Hypoadrenalism

About this section

Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1hexarelin45 3010.7CRH, POMC, GH1
2betamethasone45 1310.7CRH, POMC, GH1
3mirtazapine45 51 1311.6CRH, POMC, CYP1A2
411 deoxycortisol459.5CRH, SHBG, POMC
5allopregnanolone459.5POMC, CRH, SHBG
6sertraline45 30 51 26 1313.4POMC, CYP1A2, CRH
7anastrozole45 51 1311.3SHBG, GH1, CYP1A2
8clomiphene citrate459.2CRH, SHBG, GH1
9dehydroepiandrosterone sulfate459.2CRH, GH1, SHBG, POMC
10ketoconazole45 30 26 1312.2POMC, CRH, SHBG, CYP1A2
11dhea459.2SHBG, POMC, GH1, CRH
12carbamazepine45 51 1311.1CRH, POMC, SHBG, CYP1A2
13verapamil45 30 51 26 1313.1GH1, PTHLH, CRH, CYP1A2
14naltrexone45 30 51 1312.1POMC, GH1, CRH
15bromocriptine45 30 1311.1CYP1A2, SHBG, POMC, GH1
16nifedipine45 30 51 1312.1CYP1A2, PTHLH, CRH, GH1
17ether45 5110.0CRH, POMC, CALCA
18triiodothyronine458.9SHBG, TG, GH1, POMC
19atropine45 30 1310.9CRH, CALCA, GH1, CYP1A2
20corticosterone45 61 2610.9POMC, GH1, CALCA, CRH
21clonidine45 51 30 1311.9GH1, POMC, CYP1A2, CALCA
22propranolol45 30 51 26 1312.9GH1, CYP1A2, CALCA, CRH
23androstenedione45 269.8SHBG, POMC, GH1, CRH, CYP1A2
24rosiglitazone30 45 51 26 1312.8CYP1A2, GH1, PTHLH, SHBG
25gnrh458.7SHBG, POMC, GH1, PCSK1, CRH
26prednisolone45 30 1310.6GH1, POMC, TG, PTHLH, SHBG
27indomethacin45 30 61 1311.5PTHLH, POMC, GH1, CALCA, CRH
28ribonucleic acid458.4PTHLH, CRH, PCSK1, GH1, POMC, TG
29estradiol45 26 1310.4SHBG, POMC, CYP1A2, PTHLH, CRH, GH1
30dexamethasone45 51 30 1311.3CYP1A2, PTHLH, GH1, CRH, POMC, SHBG
31vitamin d458.2SHBG, CALCA, PTHLH, CRH, GH1
32ibmx45 61 3010.2GH1, CALCA, PTHLH, PCSK1
33alanine458.1TG, PTHLH, GH1, CRH, SHBG, POMC
34octreotide45 61 30 1311.1PTHLH, TG, POMC, GH1, CALCA, CRH
35calcitriol45 61 26 1311.1CALCA, TG, GH1, SHBG, PTHLH
36acetylcholine45 51 30 26 1312.1PTHLH, CALCA, CRH, TG, POMC, GH1
37forskolin45 51 1310.0PCSK1, PTHLH, POMC, CRH, GH1, CALCA
38dopamine45 30 26 1311.0SHBG, CYP1A2, CALCA, CRH, POMC, GH1
39acth457.9GH1, PCSK1, CALCA, CRH, SHBG, POMC
40progesterone45 30 61 26 1311.9PCSK1, SHBG, PTHLH, POMC, GH1, CRH
41lactate457.8SHBG, PTHLH, TG, GH1, CALCA
42arginine457.7CRH, GH1, POMC, PCSK1, TG, PTHLH
43epinephrine45 26 139.5CYP1A2, CRH, TG, CALCA, GH1, POMC
44hydrocortisone45 3 61 1310.5PTHLH, TG, POMC, GH1, CALCA, CRH
45thyroxine45 268.5CRH, POMC, CALCA, GH1, PTHLH, SHBG
46creatinine457.4GH1, CRH, POMC, TG, CALCA, PTHLH
47norepinephrine45 26 139.1PTHLH, CYP1A2, SHBG, TG, POMC, GH1
48testosterone45 61 26 1310.0PTHLH, SHBG, TG, POMC, GH1, CRH
49adenylate456.9POMC, SHBG, TG, CRH, CALCA, PCSK1
50estrogen456.5CALCA, PCSK1, GH1, POMC, TG, CRH

GO Terms for genes affiliated with Hypoadrenalism

About this section

Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.6PCSK1, POMC
2extracellular spaceGO:00056157.0CRH, PTHLH, TG, POMC, GH1, PCSK1
3extracellular regionGO:00055766.7SHBG, PTHLH, TG, POMC, GH1, CALCA

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.7POMC, PCSK1
2response to painGO:00482659.5CRH, CALCA
3negative regulation of blood pressureGO:00457769.4CRH, CALCA
4feeding behaviorGO:00076319.3CRH, CALCA
5regulation of gene expressionGO:00104689.3PTHLH, CYP1A2
6regulation of blood pressureGO:00082179.3CALCA, POMC
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.1PTHLH, CALCA
8positive regulation of cAMP biosynthetic processGO:00308199.1CRH, CALCA, PTHLH
9cell-cell signalingGO:00072678.5PTHLH, POMC, PCSK1, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.0CRH, CALCA, POMC
2hormone activityGO:00051797.3CRH, CALCA, GH1, POMC, TG, PTHLH

Products for genes affiliated with Hypoadrenalism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hypoadrenalism

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet