Hypoadrenalism malady

Wikipedia: Adrenal insufficiency is a condition in which the adrenal glands, located above the kidneys, do not...⁴⁴ more...

MalaCards: Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypercalcemia and addison's disease. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Selected targets of CREB1. The drugs dehydroepiandrosterone and triamcinolone acetonide and the compounds dopamine and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, kidney and adrenal gland, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

hypoadrenalism 30 32 adrenal gland hypofunction 43

Diseases related to hypoadrenalism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 247)

id	Related Disease	Score	Top Affiliating Genes
1	hypercalcemia	26.3	CALCA, PTHLH, TG, POMC
2	addison's disease	25.4	PCSK1, INS, CRH, SHBG, TG, POMC
3	diabetes insipidus	25.1	INS, CALCA, PTHLH, CRH, TG, POMC
4	isolated acth deficiency	13.4	CRH, POMC
5	hypothalamic disease	13.4	GH1, CRH
6	melancholia	13.4	CRH, POMC
7	nelson syndrome	13.4	CRH, POMC
8	neurogenic diabetes insipidus	13.4	CRH, POMC
9	infantile epileptic encephalopathy	13.4	CRH, POMC
10	acth-producing pituitary tumor	13.4	PCSK1, POMC
11	obesity with impaired prohormone processing	13.4	PCSK1, POMC
12	seasonal affective disorder	13.3	CRH, POMC
13	abcb11-related intrahepatic cholestasis	13.3	CRH, POMC
14	adrenocortical hyperplasia	13.3	CRH, POMC
15	pituitary carcinoma	13.3	CRH, POMC
16	isolated growth hormone deficiency	13.3	GH1, POMC
17	pituitary hypoplasia	13.2	GH1, POMC
18	empty sella syndrome	13.2	INS, POMC
19	hypoaldosteronism	13.2	INS, POMC
20	11-beta-hydroxylase deficiency	13.2	GH1, SHBG
21	pituitary-dependent cushing's disease	13.2	GH1, CRH, POMC
22	alopecia universalis	13.2	INS, POMC
23	rabson-mendenhall syndrome	13.2	INS, GH1
24	marasmus	13.2	GH1, SHBG
25	gonadal disease	13.2	GH1, CRH, POMC
26	cushing's syndrome	13.2	GH1, CRH, POMC
27	adrenal gland hyperfunction	13.1	GH1, CRH, POMC
28	aromatase deficiency	13.1	INS, GH1
29	hypersomnia	13.1	INS, GH1
30	laron syndrome	13.1	INS, GH1
31	adrenocorticotropic hormone deficiency	13.1	PCSK1, CRH, POMC
32	postpartum depression	13.1	CALCA, CRH
33	idiopathic juvenile osteoporosis	13.1	CALCA, GH1
34	panic disorder	13.1	GH1, CRH, POMC
35	medullary sponge kidney	13.0	INS, PTHLH
36	paranoid schizophrenia	13.0	CYP1A2, POMC
37	vipoma	13.0	CALCA, GH1
38	antley-bixler syndrome	13.0	CYP1A2, POMC
39	calciphylaxis	13.0	INS, PTHLH
40	sheehan syndrome	13.0	INS, CRH, POMC
41	adrenal adenoma	12.9	INS, CRH, POMC
42	hypokalemia	12.9	INS, CRH, POMC
43	pituitary apoplexy	12.9	INS, GH1, POMC
44	pancreatic endocrine carcinoma	12.9	CALCA, PTHLH
45	spontaneous abortion	12.9	CYP1A2, CRH, POMC
46	familial male-limited precocious puberty	12.9	GH1, SHBG, POMC
47	hidradenitis suppurativa	12.9	PTHLH, SHBG
48	hidradenitis	12.9	PTHLH, SHBG
49	androgenetic alopecia	12.8	INS, SHBG
50	obesity, association with	12.8	INS, GH1, POMC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cortisone, cortisone acetate, dehydroepiandrosterone, hydrocortisone, hydrocortisone acetate, hydrocortisone acetate pwdr [va product], hydrocortisone acetonide, hydrocortisone acetonide pwdr [va product], hydrocortisone buteprate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone probutate, hydrocortisone pwdr [va product], hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone valerate, hydrocortisone,nonsterile pwdr [va product], prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], triamcinolone, triamcinolone acetonide, triamcinolone acetonide pwdr [va product], triamcinolone diacetate, triamcinolone hexacetonide

MalaCards organs/tissues related to hypoadrenalism:

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MGI Mouse Phenotypes related to hypoadrenalism:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	PCSK1, CYP1A2
2	hematopoietic system phenotype	MP:0005397	9.0	PTHLH, TG, PCSK1
3	adipose tissue phenotype	MP:0005375	8.6	POMC, PTHLH, GH1, INS, PCSK1
4	nervous system phenotype	MP:0003631	8.0	INS, CRH, POMC, PTHLH, TG
5	growth/size phenotype	MP:0005378	7.6	INS, MYH1, PCSK1, PTHLH, GH1, CRH
6	cardiovascular system phenotype	MP:0005385	7.5	POMC, INS, CALCA, PTHLH, CYP1A2, PCSK1
7	behavior/neurological phenotype	MP:0005386	7.0	PCSK1, MYH1, INS, CALCA, PTHLH, POMC
8	homeostasis/metabolism phenotype	MP:0005376	6.4	CRH, CALCA, GH1, PTHLH, CYP1A2, TG

Articles related to hypoadrenalism:

id	Title	Authors	Year	Affiliating Genes
1	Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)	Beadsworth M.B.... Zijlstra E.E.	2008	CYP1A2
2	Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. (18990320)	Dhatariya K.K.... Nair K.S.	2008	MYH1
3	Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? (16914596)	Giordano R.... Arvat E.	2006	POMC, CRH
4	Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. (15734854)	Dhatariya K.... Nair K.S.	2005	INS
5	Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)	LibA" R.... Ambrosi B.	2004	SHBG
6	Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)	Hotta M.... Demura H.	1998	CALCA, PTHLH, TG
7	CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)	Cantalamessa L.... Peracchi G.	1990	CRH

Genes related to hypoadrenalism according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	CRH	corticotropin releasing hormone	11.0	Publications
2	POMC	proopiomelanocortin	11.0	Publications
3	GH1	growth hormone 1	11.0
4	MYH1	myosin, heavy chain 1, skeletal muscle, adult	11.0	Publications
5	PCSK1	proprotein convertase subtilisin/kexin type 1	11.0
6	PTHLH	parathyroid hormone-like hormone	11.0	Publications
7	SHBG	sex hormone-binding globulin	11.0	Publications
8	CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	11.0	Publications
9	TG	thyroglobulin	11.0	Publications
10	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
11	INS	insulin	11.0	Publications

Pathways related to hypoadrenalism according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	9.9	CRH, POMC
2	Selected targets of CREB110	9.0	PCSK1, INS, CRH
3	Class B/2 (Secretin family receptors)38	8.9	CALCA, PTHLH, CRH

Compounds related to hypoadrenalism according to GeneDecks:

(show top 50)    (show all 148)

id	Compound	Score	Top Affiliating Genes
1	dopamine32 9 18 9	13.2	GH1, CRH
2	anastrozole32 42 9 9	13.0	CYP1A2
3	hexarelin32	9.7	GH1, CRH, POMC
4	11 deoxycortisol32	9.6	SHBG, POMC, CRH
5	allopregnanolone32	9.6	POMC, CRH, SHBG
6	oxandrolone32 9 9	11.5	SHBG, GH1, INS
7	cortisone32 18	10.5	GH1, CRH, POMC, INS
8	clomiphene citrate32	9.3	SHBG, INS, CRH, GH1
9	estradiol32 9 18 9	12.3	SHBG, POMC, CYP1A2, CRH
10	mirtazapine32 34 9 9	12.3	POMC, CRH, CYP1A2
11	betamethasone32 9 9	11.3	GH1, POMC, CRH
12	carbamazepine32 34 9 9	12.3	SHBG, CRH, POMC, CYP1A2
13	ketoconazole32 42 9 18 9	13.3	CYP1A2, POMC, SHBG, CRH
14	bromocriptine32 9 9	11.2	POMC, GH1, CYP1A2, SHBG
15	metformin32 34 9 9	12.2	POMC, SHBG, GH1, INS
16	propranolol32 34 9 18 9	13.1	CRH, CALCA, CYP1A2
17	c-peptide32	9.0	SHBG, GH1, INS, PCSK1
18	dehydroepiandrosterone sulfate32	9.0	SHBG, CRH, POMC, GH1, INS
19	i-app32	9.0	CALCA, INS, PCSK1
20	dhea32	9.0	CRH, SHBG, GH1, POMC, INS
21	triiodothyronine32	8.9	SHBG, TG, POMC, GH1
22	glycerol32 9 18 9	11.9	POMC, SHBG, CRH, INS, GH1
23	clonidine32 9 9	10.8	GH1, CYP1A2, POMC, CALCA
24	atropine32 9 9	10.8	CYP1A2, GH1, CALCA, CRH
25	prednisolone32 9 9	10.8	SHBG, GH1, PTHLH, TG, POMC
26	corticosterone32 18	9.7	GH1, CALCA, POMC, CRH
27	rosiglitazone32 9 18 9	11.6	CYP1A2, GH1, SHBG, INS, PTHLH
28	gnrh32	8.6	PCSK1, CRH, INS, POMC, GH1, SHBG
29	ribonucleic acid32	8.6	TG, PCSK1, POMC, GH1, PTHLH, CRH
30	creatinine32	8.5	CRH, POMC, SHBG, PTHLH, GH1, TG
31	androstenedione32 18	9.5	INS, GH1, CYP1A2, CRH, SHBG, POMC
32	ibmx32	8.4	PTHLH, GH1, CALCA, PCSK1, INS
33	indomethacin32 9 9	10.3	CALCA, POMC, PTHLH, GH1, CRH
34	forskolin32 42 9 9	11.3	PTHLH, POMC, CRH, GH1, CALCA, PCSK1
35	progesterone32 42 9 18 9	12.2	POMC, GH1, PTHLH, SHBG, CYP1A2, CRH
36	calcitriol32 42 9 18 9	12.1	PTHLH, GH1, CALCA, SHBG, TG
37	acetylcholine32 9 18 9	11.1	CRH, PTHLH, GH1, CALCA, POMC, TG
38	dexamethasone32 42 34 9 9	12.0	SHBG, POMC, CYP1A2, INS, GH1, PTHLH
39	alanine32	7.9	PTHLH, CRH, SHBG, TG, GH1, INS
40	acth32	7.8	PCSK1, GH1, POMC, SHBG, INS, CRH
41	testosterone32 9 18 9	10.8	TG, SHBG, CALCA, PTHLH, CYP1A2, CRH
42	lactate32	7.6	INS, CALCA, GH1, PTHLH, SHBG, TG
43	octreotide32 42 9 9	10.6	GH1, PTHLH, CALCA, CRH, INS, TG
44	arginine32	7.6	SHBG, CRH, PTHLH, GH1, INS, PCSK1
45	adenylate32	7.3	GH1, PTHLH, CRH, SHBG, POMC, CALCA
46	hydrocortisone32 9 9	9.2	CRH, TG, POMC, PTHLH, GH1, CALCA
47	thyroxine32 18	8.2	POMC, TG, SHBG, CRH, CALCA, GH1
48	epinephrine32 9 18 9	10.1	POMC, TG, SHBG, CRH, GH1, INS
49	norepinephrine32 9 18 9	9.7	POMC, INS, CALCA, GH1, PTHLH, TG
50	estrogen32	6.3	PCSK1, CALCA, SHBG, TG, POMC, CYP1A2

Cellular components related to hypoadrenalism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.3	PCSK1, INS, POMC
2	extracellular space	GO:005615	7.3	INS, POMC, CRH, PTHLH, GH1, CALCA
3	extracellular region	GO:005576	6.4	INS, POMC, CALCA, GH1, PTHLH, CRH

Biological processes related to hypoadrenalism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone processing	GO:016486	9.8	PCSK1, POMC
2	positive regulation of vasodilation	GO:045909	8.8	INS, CALCA
3	cell-cell signaling	GO:007267	7.9	PCSK1, INS, CALCA, PTHLH, POMC

Molecular functions related to hypoadrenalism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	7.2	INS, CALCA, GH1, PTHLH, CRH, TG