MCID: HYP189
MIFTS: 52

Hypoadrenalism malady

Rare diseases, Endocrine diseases categories
Download this MalaCard

Summaries for Hypoadrenalism

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

MalaCards: Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypothyroidism and hypopituitarism. An important gene associated with Hypoadrenalism is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Endochondral Ossification. The drugs cortisone and dehydroepiandrosterone and the compounds hexarelin and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Hypoadrenalism

About this section
Sources:
62UMLS, 43NIH Rare Diseases, 45Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypoadrenalism 43 45
adrenal gland hypofunction 62


Related Diseases for Hypoadrenalism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.3SHBG, TG
2hypopituitarism30.3GH1, SHBG, CRH, POMC
3addison's disease30.1CRH, PCSK1, POMC, TG
4panhypopituitarism30.1POMC, GH1
5cushing's syndrome30.1POMC, CRH
6amenorrhea30.0POMC, SHBG, CRH
7hypogonadism29.9GH1, PCSK1, POMC, CALCA, CRH, SHBG
8hypercalcemia29.9PTHLH, CALCA
9hyperthyroidism29.9PCSK1, SHBG, TG, GH1
10diabetes mellitus29.8CALCA, GH1, POMC, SHBG
11tuberculosis10.2
12pituitary apoplexy10.1POMC
13seasonal affective disorder10.1CRH
14adrenal carcinoma10.1POMC
15pituitary carcinoma10.1POMC
16marasmus10.1GH1
17vipoma10.1GH1
18pulmonary tuberculosis10.1
19diabetes insipidus10.1
20endogenous depression10.1POMC, CRH
21sheehan syndrome10.1POMC, CRH
22nelson syndrome10.1CRH, POMC
23melancholia10.1POMC, CRH
24infantile epileptic encephalopathy10.1POMC, CRH
25hypothalamic disease10.1CRH, GH1
26chronic fatigue syndrome10.1CRH, POMC
27craniopharyngioma10.1POMC, GH1
28congenital adrenal hyperplasia10.1CRH, POMC
29panic disorder10.1POMC, CRH
30adrenocortical carcinoma10.1POMC, CRH
31adrenal adenoma10.1POMC, CRH
32glucagonoma10.1PCSK1, GH1
33leydig cell tumor10.1PTHLH, POMC
34dwarfism10.1PTHLH, GH1
35acth-secreting pituitary adenoma10.1POMC, CRH, GH1
36gonadal disease10.1POMC, GH1, CRH
37pituitary gland disease10.1POMC, CRH, GH1
38adrenal gland hyperfunction10.1POMC, CRH, GH1
39growth hormone deficiency10.1POMC, CRH, GH1
40hypoglycemia10.0CRH, GH1, POMC
41polycystic ovary syndrome10.0GH1, SHBG
42mood disorder10.0CRH, POMC
43plummer's disease10.0SHBG, TG
44thyroid hormone resistance syndrome10.0SHBG, TG
45prolactinoma10.0PTHLH, POMC, GH1
46hyperinsulinism10.0GH1, SHBG
47thyrotropin deficiency, isolated10.0TG, GH1, POMC
48idiopathic juvenile osteoporosis10.0GH1, CALCA
49neuroendocrine tumor10.0CALCA, POMC
50thyroid adenoma10.0TG, SHBG

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to hypoadrenalism

Symptoms for Hypoadrenalism

About this section

Genetic Tests for Hypoadrenalism

About this section

Anatomical Context for Hypoadrenalism

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypoadrenalism:

33
Adrenal gland, Testes, Pituitary, Brain, Skin, Skeletal muscle

Animal Models for Hypoadrenalism or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Hypoadrenalism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PTHLH, POMC, GH1, PCSK1
2MP:00053888.5CRH, CALCA, PTHLH, CYP1A2
3MP:00053978.0CYP1A2, PTHLH, TG, POMC, PCSK1, CRH
4MP:00053787.8PTHLH, TG, POMC, GH1, PCSK1, CRH
5MP:00053797.7CRH, CYP1A2, PTHLH, TG, POMC, GH1
6MP:00053867.7CYP1A2, PTHLH, POMC, PCSK1, CALCA, CRH
7MP:00036317.6PTHLH, TG, POMC, GH1, CALCA, CRH
8MP:00053857.6CYP1A2, PTHLH, POMC, PCSK1, CALCA
9MP:00053766.9CYP1A2, PTHLH, TG, POMC, GH1, PCSK1

Publications for Hypoadrenalism

About this section
Sources:
52PubMed
See all sources

Articles related to Hypoadrenalism:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. (22998100)
2013
2
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. (23729816)
2013
3
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
4
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? (23422765)
2012
5
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. (22402482)
2012
6
Painful hypoadrenalism. (22700071)
2011
7
Hypoadrenalism presenting as a range of mental disorders. (22707626)
2011
8
Clinical Review#: The diagnosis and management of central hypoadrenalism. (20719838)
2010
9
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? (19266139)
2009
10
Hypoadrenalism following trauma: is sepsis always necessary? (19079677)
2008
11
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. (18284838)
2008
12
Secondary hypoadrenalism. (18418713)
2008
13
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. (18704214)
2008
14
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. (18801174)
2008
15
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
16
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. (16218046)
2005
17
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. (15636426)
2004
18
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. (14635559)
2003
19
CHARGE association and secondary hypoadrenalism. (12567418)
2003
20
Cerebral salt wasting syndrome or secondary hypoadrenalism? (11433653)
2001
21
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. (11155100)
2000
22
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. (10395233)
1998
23
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. (9522797)
1998
24
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. (9894388)
1998
25
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9373445)
1997
26
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. (9274709)
1997
27
Diagnosis of secondary hypoadrenalism. (8796149)
1996
28
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. (8736284)
1995
29
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. (8822324)
1995
30
Secondary hypoadrenalism presenting with hypercalcaemia. (7923833)
1994
31
Secondary hypoadrenalism with hypercalcaemia. (7889623)
1994
32
Occult hypoadrenalism in critically ill patients. (8154974)
1994
33
Bilateral adrenal infarction, hypoadrenalism and splinter haemorrhages in the 'primary' antiphospholipid syndrome. (1737226)
1992
34
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. (2169450)
1990
35
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
36
Non-Hodgkin's lymphoma as a cause of hypoadrenalism. (3328977)
1987
37
Acute hypoadrenalism and hepatotoxicity after treatment with ketoconazole. (2881126)
1987
38
Transient hypoadrenalism after transsphenoidal pituitary surgery for Cushing's disease may not predict long-term cure. (3467203)
1986
39
Methadone-induced hypoadrenalism. (6132074)
1983
40
Transitory hypoadrenalism due to long-term treatment with antiovulatory compounds. (221439)
1979
41
Chronic hyper- and hypoadrenalism. Part I. Populational and experimental studies. (866973)
1977
42
Sebum excretion and melanocyte-stimulating hormone in hypoadrenalism. (4854211)
1974
43
Differential diagnosis of the month: hypoadrenalism. (5834310)
1965
44
DIAGNOSIS AND MANAGEMENT OF HYPOADRENALISM. (14067669)
1963
45
Hyperthyroidism and hypoadrenalism simultaneously. Case report. (13689481)
1961
46
Induced hypoadrenalism in patients requiring orthopedic surgery. (13415973)
1957
47
Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant. (13332518)
1956
48
Effect of hypoadrenalism and excessive doses of desoxycorticosterone acetate upon response of the rat to ouabain. (14364765)
1955
49
Sodium-retaining corticoid in the urine of normal children and adults and of patients with hypoadrenalism or hypopituitarism. (13192179)
1954
50
Hypoadrenalism in newborn infants; a case report. (14861449)
1951

Variations for Hypoadrenalism

About this section

Expression for genes affiliated with Hypoadrenalism

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for genes affiliated with Hypoadrenalism

About this section
Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 53QIAGEN, 55Reactome, 60Thomson Reuters, 30KEGG
See all sources

Pathways related to Hypoadrenalism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
29.6GH1, PTHLH
39.6CRH, PCSK1
4
Show member pathways
9.4CRH, GH1, POMC
5
Show member pathways
9.2POMC, GH1, PCSK1
6
Show member pathways
8.5PTHLH, POMC, CALCA, CRH
78.5CRH, CALCA, POMC, PTHLH
8
Show member pathways
8.2CRH, CALCA, GH1, POMC, PTHLH
9
Show member pathways
8.2PTHLH, POMC, GH1, CALCA, CRH

Compounds for genes affiliated with Hypoadrenalism

About this section
Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Hypoadrenalism according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1hexarelin45 2910.7CRH, POMC, GH1
2betamethasone45 1110.7CRH, POMC, GH1
3mirtazapine45 51 1111.6CRH, POMC, CYP1A2
411 deoxycortisol459.5CRH, SHBG, POMC
5allopregnanolone459.5POMC, CRH, SHBG
6sertraline45 29 51 24 1113.4POMC, CYP1A2, CRH
7anastrozole45 51 1111.3SHBG, GH1, CYP1A2
8clomiphene citrate459.2CRH, SHBG, GH1
9dehydroepiandrosterone sulfate459.2CRH, GH1, SHBG, POMC
10ketoconazole45 29 24 1112.2POMC, CRH, SHBG, CYP1A2
11dhea459.2SHBG, POMC, GH1, CRH
12carbamazepine45 51 1111.1CRH, POMC, SHBG, CYP1A2
13verapamil45 29 51 24 1113.1GH1, PTHLH, CRH, CYP1A2
14naltrexone45 29 51 1112.1POMC, GH1, CRH
15bromocriptine45 29 1111.1CYP1A2, SHBG, POMC, GH1
16nifedipine45 29 51 1112.1CYP1A2, PTHLH, CRH, GH1
17ether45 5110.0CRH, POMC, CALCA
18triiodothyronine458.9SHBG, TG, GH1, POMC
19atropine45 29 1110.9CRH, CALCA, GH1, CYP1A2
20corticosterone45 61 2410.9POMC, GH1, CALCA, CRH
21clonidine45 51 29 1111.9GH1, POMC, CYP1A2, CALCA
22propranolol45 29 51 24 1112.9GH1, CYP1A2, CALCA, CRH
23androstenedione45 249.8SHBG, POMC, GH1, CRH, CYP1A2
24rosiglitazone29 45 51 24 1112.8CYP1A2, GH1, PTHLH, SHBG
25gnrh458.7SHBG, POMC, GH1, PCSK1, CRH
26prednisolone45 29 1110.6GH1, POMC, TG, PTHLH, SHBG
27indomethacin45 29 61 1111.5PTHLH, POMC, GH1, CALCA, CRH
28ribonucleic acid458.4PTHLH, CRH, PCSK1, GH1, POMC, TG
29estradiol45 24 1110.4SHBG, POMC, CYP1A2, PTHLH, CRH, GH1
30dexamethasone45 51 29 1111.3CYP1A2, PTHLH, GH1, CRH, POMC, SHBG
31vitamin d458.2SHBG, CALCA, PTHLH, CRH, GH1
32ibmx45 61 2910.2GH1, CALCA, PTHLH, PCSK1
33alanine458.1TG, PTHLH, GH1, CRH, SHBG, POMC
34octreotide45 61 29 1111.1PTHLH, TG, POMC, GH1, CALCA, CRH
35calcitriol45 61 24 1111.1CALCA, TG, GH1, SHBG, PTHLH
36acetylcholine45 51 29 24 1112.1PTHLH, CALCA, CRH, TG, POMC, GH1
37forskolin45 51 1110.0PCSK1, PTHLH, POMC, CRH, GH1, CALCA
38dopamine45 29 24 1111.0SHBG, CYP1A2, CALCA, CRH, POMC, GH1
39acth457.9GH1, PCSK1, CALCA, CRH, SHBG, POMC
40progesterone45 29 61 24 1111.9PCSK1, SHBG, PTHLH, POMC, GH1, CRH
41lactate457.8SHBG, PTHLH, TG, GH1, CALCA
42arginine457.7CRH, GH1, POMC, PCSK1, TG, PTHLH
43epinephrine45 24 119.5CYP1A2, CRH, TG, CALCA, GH1, POMC
44hydrocortisone45 3 61 1110.5PTHLH, TG, POMC, GH1, CALCA, CRH
45thyroxine45 248.5CRH, POMC, CALCA, GH1, PTHLH, SHBG
46creatinine457.4GH1, CRH, POMC, TG, CALCA, PTHLH
47norepinephrine45 24 119.1PTHLH, CYP1A2, SHBG, TG, POMC, GH1
48testosterone45 61 24 1110.0PTHLH, SHBG, TG, POMC, GH1, CRH
49adenylate456.9POMC, SHBG, TG, CRH, CALCA, PCSK1
50estrogen456.5CALCA, PCSK1, GH1, POMC, TG, CRH

GO Terms for genes affiliated with Hypoadrenalism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6PCSK1, POMC
2extracellular spaceGO:0056157.0CALCA, PTHLH, TG, POMC, GH1, PCSK1
3extracellular regionGO:0055766.7CRH, SHBG, PTHLH, TG, POMC, GH1

Biological processes related to Hypoadrenalism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.7POMC, PCSK1
2response to painGO:0482659.5CRH, CALCA
3negative regulation of blood pressureGO:0457769.4CRH, CALCA
4feeding behaviorGO:0076319.3CRH, CALCA
5regulation of gene expressionGO:0104689.3PTHLH, CYP1A2
6regulation of blood pressureGO:0082179.3CALCA, POMC
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.1PTHLH, CALCA
8positive regulation of cAMP biosynthetic processGO:0308199.1CRH, CALCA, PTHLH
9cell-cell signalingGO:0072678.5PTHLH, POMC, PCSK1, CALCA

Molecular functions related to Hypoadrenalism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.0CRH, CALCA, POMC
2hormone activityGO:0051797.3CRH, CALCA, GH1, POMC, TG, PTHLH

Products for genes affiliated with Hypoadrenalism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypoadrenalism

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet