MCID: HYP189
MIFTS: 43

Hypoadrenalism

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoadrenalism

MalaCards integrated aliases for Hypoadrenalism:

Name: Hypoadrenalism 49 51
Adrenal Gland Hypofunction 69
Hypoaldosteronism 69

Classifications:



External Ids:

Summaries for Hypoadrenalism

MalaCards based summary : Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypoadrenocorticism, familial and hypopituitarism. An important gene associated with Hypoadrenalism is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Neuroscience and Presynaptic function of Kainate receptors. The drugs Dexamethasone and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related phenotype is endocrine/exocrine gland.

Wikipedia : 72 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

Related Diseases for Hypoadrenalism

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 hypoadrenocorticism, familial 31.8 CRH POMC
2 hypopituitarism 30.0 CRH GH1 POMC
3 diabetes insipidus 29.9 CRH POMC
4 functioning pituitary adenoma 29.9 GH1 POMC
5 pituitary hormone deficiency, combined, 2 29.8 GH1 POMC
6 hypercalcemia, infantile, 1 29.8 CALCA PTHLH
7 amenorrhea 29.7 CRH POMC SHBG
8 adrenal gland hyperfunction 29.6 CRH GH1 POMC
9 pituitary adenoma 29.6 CRH GH1 POMC
10 hyperthyroidism 29.0 GH1 SHBG TG
11 achalasia-addisonianism-alacrima syndrome 11.1
12 proprotein convertase 1/3 deficiency 11.0
13 acth deficiency, isolated 10.4 CRH POMC
14 pituitary carcinoma 10.4 CRH POMC
15 nelson syndrome 10.4 CRH POMC
16 sheehan syndrome 10.4 CRH POMC
17 acth-secreting pituitary adenoma 10.4 CRH POMC
18 fasting hypoglycemia 10.4 CRH POMC
19 adrenal cortical hypofunction 10.4 CRH POMC
20 withdrawal disorder 10.3 CRH POMC
21 hyperproinsulinemia 10.3 PCSK1 SHBG
22 persistent fetal circulation syndrome 10.3 CRH POMC
23 adrenal cortex disease 10.3 CRH POMC
24 adrenal gland disease 10.3 CRH POMC
25 ectopic cushing syndrome 10.3 CRH POMC
26 pituitary-dependent cushing's disease 10.3 CRH POMC
27 cytochrome p450 oxidoreductase deficiency 10.3 CYP1A2 POMC
28 lymphocytic hypophysitis 10.3 GH1 POMC
29 adenohypophysitis 10.3 GH1 POMC
30 fetal erythroblastosis 10.3 POMC SHBG
31 sex differentiation disease 10.3 POMC SHBG
32 empty sella syndrome 10.3 GH1 POMC
33 hyperpituitarism 10.3 GH1 POMC
34 mental depression 10.3 CRH POMC
35 adrenal adenoma 10.2 CRH POMC
36 chromophobe adenoma 10.2 GH1 POMC
37 secondary hypertrophic osteoarthropathy 10.2 CALCA POMC
38 marasmus 10.2 GH1 SHBG
39 gynecomastia 10.2 POMC SHBG
40 pituitary tumors 10.2 GH1 POMC
41 female reproductive system disease 10.1 POMC SHBG
42 hyperandrogenism 10.1 POMC SHBG
43 postpartum depression 10.1 CALCA CRH
44 islet cell tumor 10.1 CALCA PTHLH
45 premenstrual tension 10.1 CRH POMC SHBG
46 parathyroid gland disease 10.1 CALCA PTHLH
47 endocrine exophthalmos 10.1 POMC TG
48 thyroid crisis 10.1 POMC TG
49 adrenal carcinoma 10.1 CRH POMC
50 acquired metabolic disease 10.0 POMC PTHLH SHBG

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to Hypoadrenalism

Symptoms & Phenotypes for Hypoadrenalism

MGI Mouse Phenotypes related to Hypoadrenalism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CRH CYP1A2 PCSK1 POMC PTHLH TG

Drugs & Therapeutics for Hypoadrenalism

Drugs for Hypoadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 272)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 657311 5754
4
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
5 Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1 329-65-7
6
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
7
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
8
rituximab Approved Phase 4,Phase 2 174722-31-7 10201696
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Cortisone acetate Approved, Investigational Phase 4 1950-04-4, 50-04-4 5745
13
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
14
Etomidate Approved Phase 4,Phase 2,Phase 3 33125-97-2 667484 36339
15
Menthol Approved Phase 4 2216-51-5 16666
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
17
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
18
Cosyntropin Approved Phase 4,Phase 3 16960-16-0 16129617
19
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
20
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
21
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
22 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
23
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1 107-92-6 264
24 Dexamethasone acetate Phase 4,Phase 1 1177-87-3
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
26 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1
29 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1
30 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1
31 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1
32 Adrenocorticotropic Hormone Phase 4,Phase 1
33 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1
35 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3,Phase 1
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
39 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
40 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1
42 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1
43 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1
44 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1
45 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
47 Liver Extracts Phase 4,Phase 3,Phase 2
48 BB 1101 Phase 4,Phase 1
49 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 173)

# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
3 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
4 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
5 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
6 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
7 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
8 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
9 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
10 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
12 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
13 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
14 Salt Loading and Thiazide Intervention Study Completed NCT00896389 Phase 4 Hydrochlorothiazide (HCTZ)
15 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
16 Rescue of Steroidogenic Capacity in Adrenocortical Failure Study (RADS) Completed NCT00753597 Phase 4 Solu-medrone, Mabthera
17 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
18 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Recruiting NCT02997605 Phase 4 GlucoCorticoid
19 Corticosteroid Reduction in COPD Recruiting NCT02857842 Phase 4 Prednisolone
20 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
21 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Active, not recruiting NCT02206256 Phase 4 Omega-3 fatty acid capsules
22 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
23 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
24 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
25 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
26 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
27 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
28 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
29 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
30 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
31 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
32 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
33 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
34 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
35 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
36 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
37 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
38 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
39 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
40 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
41 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
42 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
43 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
44 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
45 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
46 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
47 PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer? Recruiting NCT03265574 Phase 3 Enalapril
48 A Phase 2/3 Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Recruiting NCT01896102 Phase 2, Phase 3
49 Extension Study for Patients Entered Into Study Infacort 003 Active, not recruiting NCT02733367 Phase 3 Infacort®
50 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Active, not recruiting NCT02105415 Phase 2, Phase 3 Ketamine / Propofol Admixture;Etomidate

Search NIH Clinical Center for Hypoadrenalism

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

MalaCards organs/tissues related to Hypoadrenalism:

38
Adrenal Gland, Testes, Pituitary, Brain, Thyroid, Breast, Lung

Publications for Hypoadrenalism

Articles related to Hypoadrenalism:

(show top 50) (show all 90)
# Title Authors Year
1
Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH-independent hypercortisolism. ( 29151238 )
2017
2
Letter to the Editor: Including the Zona Reticularis in the Definition of Hypoadrenalism and Hyperadrenalism. ( 28911156 )
2017
3
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
4
A Case of Autoimmune Polyglandular Syndrome (APS) Type II with Hypothyroidism, Hypoadrenalism, and Celiac Disease - A Rare Combination. ( 26023582 )
2015
5
Hypoadrenalism secondary to topical corticosteroid-containing skin-lightening cream: danger of over-the-counter cosmetic agents. ( 26424061 )
2015
6
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. ( 24615601 )
2014
7
Central hypoadrenalism. ( 25140404 )
2014
8
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. ( 23729816 )
2013
9
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. ( 22998100 )
2013
10
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. ( 23365166 )
2013
11
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? ( 23422765 )
2012
12
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. ( 22402482 )
2012
13
Painful hypoadrenalism. ( 22700071 )
2011
14
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. ( 21986010 )
2011
15
Hypoadrenalism presenting as a range of mental disorders. ( 22707626 )
2011
16
Clinical Review#: The diagnosis and management of central hypoadrenalism. ( 20719838 )
2010
17
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement. ( 19131388 )
2009
18
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? ( 19266139 )
2009
19
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. ( 20016446 )
2009
20
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. ( 18284838 )
2008
21
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. ( 18704214 )
2008
22
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. ( 18801174 )
2008
23
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. ( 18990320 )
2008
24
Secondary hypoadrenalism. ( 18418713 )
2008
25
Hypoadrenalism following trauma: is sepsis always necessary? ( 19079677 )
2008
26
Doses and steroids to be used in primary and central hypoadrenalism. ( 17651687 )
2007
27
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. ( 17888053 )
2007
28
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. ( 16414105 )
2006
29
Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? ( 16914596 )
2006
30
Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. ( 15734854 )
2005
31
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. ( 16218046 )
2005
32
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. ( 16508710 )
2005
33
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. ( 15636426 )
2004
34
CHARGE association and secondary hypoadrenalism. ( 12567418 )
2003
35
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. ( 14635559 )
2003
36
Cerebral salt wasting syndrome or secondary hypoadrenalism? ( 11433653 )
2001
37
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 11155100 )
2000
38
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 10931104 )
2000
39
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. ( 10984555 )
2000
40
The role of the low dose ACTH test in the evaluation of central hypoadrenalism. ( 10435862 )
1999
41
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. ( 9522797 )
1998
42
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. ( 9894388 )
1998
43
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. ( 10395233 )
1998
44
Transient hypoadrenalism during surgical critical illness. ( 9484735 )
1998
45
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9373445 )
1997
46
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9274709 )
1997
47
Diagnosis of secondary hypoadrenalism. ( 8796149 )
1996
48
Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. ( 8849565 )
1996
49
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. ( 8736284 )
1995
50
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. ( 8822324 )
1995

Variations for Hypoadrenalism

Expression for Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for Hypoadrenalism

GO Terms for Hypoadrenalism

Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CALCA CRH GH1 POMC PTHLH SHBG
2 extracellular space GO:0005615 9.17 CALCA CRH GH1 PCSK1 POMC PTHLH

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.46 CALCA PCSK1 POMC PTHLH
2 negative regulation of blood pressure GO:0045776 9.4 CALCA CRH
3 response to immobilization stress GO:0035902 9.37 CRH CYP1A2
4 peptide hormone processing GO:0016486 9.32 PCSK1 POMC
5 response to pain GO:0048265 9.26 CALCA CRH
6 positive regulation of cAMP biosynthetic process GO:0030819 9.13 CALCA CRH PTHLH
7 regulation of receptor activity GO:0010469 9.02 CALCA GH1 POMC PTHLH TG

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 CALCA CRH GH1 POMC PTHLH TG
2 neuropeptide hormone activity GO:0005184 8.96 CRH POMC

Sources for Hypoadrenalism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
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70 UMLS via Orphanet
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