Aliases & Classifications for Hypoadrenalism

MalaCards integrated aliases for Hypoadrenalism:

Name: Hypoadrenalism 50 52
Adrenal Gland Hypofunction 69
Hypoaldosteronism 69

Classifications:



Summaries for Hypoadrenalism

MalaCards based summary : Hypoadrenalism, also known as adrenal gland hypofunction, is related to addison's disease and obesity with impaired prohormone processing. An important gene associated with Hypoadrenalism is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Neuroscience and Presynaptic function of Kainate receptors. The drugs Epinephrine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related phenotype is endocrine/exocrine gland.

Related Diseases for Hypoadrenalism

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 addison's disease 11.1
2 obesity with impaired prohormone processing 10.9
3 achalasia-addisonianism-alacrimia syndrome 10.8
4 sesame syndrome 10.7 PCSK1 POMC
5 renal pelvis carcinoma 10.6 CRH POMC
6 actinobacillosis 10.6 CRH POMC
7 ulcerative blepharitis 10.6 CRH POMC
8 febrile infection-related epilepsy syndrome 10.6 CRH POMC
9 dressler's syndrome 10.6 CRH POMC
10 autoimmune disease of central nervous system 10.5 CRH POMC
11 early-onset parkinson disease 10.5 CRH POMC
12 traumatic glaucoma 10.5 CRH POMC
13 maturity-onset diabetes of the young, type 10 10.5 PCSK1 SHBG
14 trabecular follicular adenocarcinoma 10.5 CRH POMC
15 bronchiectasis 10.5 CRH POMC
16 acute myocarditis 10.5 CRH POMC
17 conjunctival vascular disease 10.5 POMC SHBG
18 lymphoma, gastric non hodgkins type 10.5 GH1 POMC
19 aortic valve atresia 10.5 GH1 POMC
20 dfna2 nonsyndromic hearing loss 10.5 CYP1A2 POMC
21 sphingolipidosis 10.5 POMC SHBG
22 lactic acidosis 10.4 GH1 POMC
23 vestibular gland benign neoplasm 10.4 CRH POMC
24 protein s deficiency 10.4 GH1 POMC
25 keratosis 10.4 CRH POMC
26 strabismus 10.4 GH1 POMC
27 posterior uveal melanoma 10.4 CRH POMC
28 diencephalic neoplasm 10.4 GH1 POMC
29 capillary disease 10.4 POMC SHBG
30 seminal vesicle chronic gonorrhea 10.3 CALCA POMC
31 male genital organ stricture 10.3 GH1 SHBG
32 psychogenic movement 10.3 GH1 POMC
33 molybdenum cofactor deficiency b 10.3 GH1 POMC
34 adrenal cortical adenocarcinoma 10.3 CRH POMC
35 spondylolysis 10.3 POMC SHBG
36 waardenburg syndrome, type 4b 10.3 CALCA PTHLH
37 pelvic muscle wasting 10.2 POMC SHBG
38 chronic dacryoadenitis 10.2 CALCA CRH
39 kartagener syndrome 10.2 CALCA PTHLH
40 opioid abuse 10.2 CALCA PTHLH
41 uterine corpus adenocarcinofibroma 10.2 CRH POMC SHBG
42 thyrotoxic exophthalmos 10.2 POMC TG
43 acute gonococcal salpingitis 10.2 CRH POMC SHBG
44 guillain-barre syndrome 10.2 POMC TG
45 hypertensive encephalopathy 10.1 CRH POMC
46 hallucinogen dependence 10.1 CRH POMC
47 survival motor neuron spinal muscular atrophy 10.1 POMC PTHLH SHBG
48 intermittent squint 10.1 CRH GH1 POMC
49 adrenal cortex disease 10.1 CRH GH1 POMC
50 uterine ligament clear cell adenocarcinoma 10.1 CRH GH1 POMC

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to Hypoadrenalism

Symptoms & Phenotypes for Hypoadrenalism

MGI Mouse Phenotypes related to Hypoadrenalism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CRH CYP1A2 PCSK1 POMC PTHLH TG

Drugs & Therapeutics for Hypoadrenalism

Drugs for Hypoadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 259)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
3 Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1
4
Cosyntropin Approved Phase 4 16960-16-0 16129617
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
6
Fludrocortisone Approved Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
7
Menthol Approved Phase 4 2216-51-5 16666
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
9
Cortisone acetate Approved Phase 4 1950-04-4, 50-04-4 5745
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
12
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
13
Etomidate Approved Phase 4,Phase 2,Phase 3 33125-97-2 36339 667484
14
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
15
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
16
Xylometazoline Approved Phase 4 526-36-3 5709
17
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
18
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
19
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
20
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
21 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
22
Butyric Acid Experimental Phase 4,Phase 2,Phase 3,Phase 1 107-92-6 264
23 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1
25 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1
26 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
30 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1
31 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1
32 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1
33 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
35 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
36 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
37 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 BB 1101 Phase 4,Phase 1
40 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Dexamethasone acetate Phase 4,Phase 1 1177-87-3
42 Mydriatics Phase 4,Phase 3,Phase 2,Phase 1
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
48 Adrenocorticotropic Hormone Phase 4,Phase 1
49 Liver Extracts Phase 4,Phase 3,Phase 2
50 Antiemetics Phase 4,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 160)

id Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4 Synacthen (Tetracosactrin)
3 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
4 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
5 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
6 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
7 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
8 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
9 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
10 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
12 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
13 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
14 Salt Loading and Thiazide Intervention Study Completed NCT00896389 Phase 4 Hydrochlorothiazide (HCTZ)
15 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
16 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
17 Corticosteroid Reduction in COPD Recruiting NCT02857842 Phase 4 Prednisolone
18 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
19 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Active, not recruiting NCT02206256 Phase 4 Omega-3 fatty acid capsules
20 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
21 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
22 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
23 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Not yet recruiting NCT02997605 Phase 4 GlucoCorticoid
24 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
25 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
26 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
27 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
28 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
29 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
30 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
31 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
32 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
33 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
34 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
35 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
36 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
37 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
38 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
39 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
40 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
41 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
42 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
43 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
44 Extension Study for Patients Entered Into Study Infacort 003 Recruiting NCT02733367 Phase 3 Infacort®
45 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
46 A Phase 2/3 Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Recruiting NCT01896102 Phase 2, Phase 3
47 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Enrolling by invitation NCT02105415 Phase 2, Phase 3 Ketamine / Propofol Admixture;Etomidate
48 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
49 A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients. Not yet recruiting NCT03231878 Phase 2, Phase 3 MIN-102;Placebos
50 Effect of Glycerol Trierucate on Clinical Course of Adrenoleukodystrophy Suspended NCT00004418 Phase 2, Phase 3 glyceryl trierucate;glyceryl trioleate

Search NIH Clinical Center for Hypoadrenalism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

MalaCards organs/tissues related to Hypoadrenalism:

39
Testes, Pituitary, Brain, Thyroid, Lung, Liver, Bone

Publications for Hypoadrenalism

Articles related to Hypoadrenalism:

(show top 50) (show all 89)
id Title Authors Year
1
Letter to the Editor: Including the Zona Reticularis in the Definition of Hypoadrenalism and Hyperadrenalism. ( 28911156 )
2017
2
Hypoadrenalism secondary to topical corticosteroid-containing skin-lightening cream: danger of over-the-counter cosmetic agents. ( 26424061 )
2015
3
A Case of Autoimmune Polyglandular Syndrome (APS) Type II with Hypothyroidism, Hypoadrenalism, and Celiac Disease - A Rare Combination. ( 26023582 )
2015
4
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
5
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. ( 24615601 )
2014
6
Central hypoadrenalism. ( 25140404 )
2014
7
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. ( 23729816 )
2013
8
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. ( 23365166 )
2013
9
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. ( 22998100 )
2013
10
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? ( 23422765 )
2012
11
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. ( 22402482 )
2012
12
Painful hypoadrenalism. ( 22700071 )
2011
13
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. ( 21986010 )
2011
14
Hypoadrenalism presenting as a range of mental disorders. ( 22707626 )
2011
15
Clinical Review#: The diagnosis and management of central hypoadrenalism. ( 20719838 )
2010
16
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? ( 19266139 )
2009
17
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. ( 20016446 )
2009
18
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement. ( 19131388 )
2009
19
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. ( 18284838 )
2008
20
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. ( 18704214 )
2008
21
Secondary hypoadrenalism. ( 18418713 )
2008
22
Hypoadrenalism following trauma: is sepsis always necessary? ( 19079677 )
2008
23
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. ( 18990320 )
2008
24
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. ( 18801174 )
2008
25
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. ( 17888053 )
2007
26
Doses and steroids to be used in primary and central hypoadrenalism. ( 17651687 )
2007
27
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. ( 16414105 )
2006
28
Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? ( 16914596 )
2006
29
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. ( 16218046 )
2005
30
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. ( 16508710 )
2005
31
Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. ( 15734854 )
2005
32
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. ( 15636426 )
2004
33
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. ( 14635559 )
2003
34
CHARGE association and secondary hypoadrenalism. ( 12567418 )
2003
35
Cerebral salt wasting syndrome or secondary hypoadrenalism? ( 11433653 )
2001
36
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 10931104 )
2000
37
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 11155100 )
2000
38
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. ( 10984555 )
2000
39
The role of the low dose ACTH test in the evaluation of central hypoadrenalism. ( 10435862 )
1999
40
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. ( 9522797 )
1998
41
Transient hypoadrenalism during surgical critical illness. ( 9484735 )
1998
42
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. ( 9894388 )
1998
43
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. ( 10395233 )
1998
44
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9274709 )
1997
45
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9373445 )
1997
46
Diagnosis of secondary hypoadrenalism. ( 8796149 )
1996
47
Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. ( 8849565 )
1996
48
A case of initially undiagnosed hypoadrenalism presenting inappropriate secretion of anti-diuretic hormone. ( 8822324 )
1995
49
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. ( 8736284 )
1995
50
Occult hypoadrenalism in critically ill patients. ( 8154974 )
1994

Variations for Hypoadrenalism

Expression for Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for Hypoadrenalism

GO Terms for Hypoadrenalism

Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CALCA CRH GH1 POMC PTHLH SHBG
2 extracellular space GO:0005615 9.1 CALCA CRH GH1 PCSK1 POMC PTHLH

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.4 CALCA PTHLH
2 negative regulation of blood pressure GO:0045776 9.37 CALCA CRH
3 response to immobilization stress GO:0035902 9.32 CRH CYP1A2
4 peptide hormone processing GO:0016486 9.26 PCSK1 POMC
5 cell-cell signaling GO:0007267 9.26 CALCA PCSK1 POMC PTHLH
6 response to pain GO:0048265 9.16 CALCA CRH
7 positive regulation of cAMP biosynthetic process GO:0030819 8.8 CALCA CRH PTHLH

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 CALCA CRH GH1 POMC PTHLH TG
2 neuropeptide hormone activity GO:0005184 8.65 CRH

Sources for Hypoadrenalism

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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30 HGMD
31 HMDB
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34 ICD10 via Orphanet
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65 SNOMED-CT via HPO
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