MCID: HYP121
MIFTS: 61

Hypoalphalipoproteinemia malady

Categories: Genetic diseases, Rare diseases, Metabolic diseases, Endocrine diseases

Aliases & Classifications for Hypoalphalipoproteinemia

About this section
Sources:
12diseasecard, 25Genetics Home Reference, 26GTR, 30ICD10 via Orphanet, 36MedGen, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Hypoalphalipoproteinemia:

Name: Hypoalphalipoproteinemia 51 26 49
Hdl Deficiency, Type 2 51 25 12 67
Familial Hypoalphalipoproteinemia 25 53 69
Familial Hdl Deficiency 47 25 67
Fha 47 25 69
High Density Lipoprotein Deficiency 47 67
Hypoalphalipoproteinemia, Familial 47 67
Hypoalphalipoproteinemia, Primary 51 47
Apolipoprotein a-I Deficiency 53 67
Hdld 47 25
 
High Density Lipoprotein Deficiency 2 69
Familial Hypoalphalipo-Proteinemia 26
Primary Hypoalphalipoproteinemia 25
Familial Apoa-I Deficiency 53
Hypoalphalipoproteinemias 67
Low Serum Hdl Cholesterol 25
Apoa-I Deficiency 53
Hdld2 69
Fhd 47

Characteristics:

Orphanet epidemiological data:

53
familial hypoalphalipoproteinemia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age

HPO:

63
hypoalphalipoproteinemia:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM51 604091
Orphanet53 ORPHA425
ICD10 via Orphanet30 E78.6
MESH via Orphanet39 D052456
UMLS via Orphanet68 C0342898, C1704429

Summaries for Hypoalphalipoproteinemia

About this section
Genetics Home Reference:25 Familial HDL deficiency is a condition characterized by low levels of high-density lipoprotein (HDL) in the blood. HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. HDL is often referred to as "good cholesterol" because high levels of this substance reduce the chances of developing heart and blood vessel (cardiovascular) disease. People with familial HDL deficiency may develop cardiovascular disease at a relatively young age, often before age 50.

MalaCards based summary: Hypoalphalipoproteinemia, also known as hdl deficiency, type 2, is related to obesity and coronary artery disease, and has symptoms including multiple lipomas, coronary artery disease and cerebral ischemia. An important gene associated with Hypoalphalipoproteinemia is ABCA1 (ATP Binding Cassette Subfamily A Member 1), and among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) and Folate Metabolism. Affiliated tissues include liver, heart and endothelial, and related mouse phenotypes are pigmentation and endocrine/exocrine gland.

UniProtKB/Swiss-Prot:69 High density lipoprotein deficiency 2: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.

OMIM:51 Twenty to 30% of early familial coronary heart disease (CHD) is ascribed to hypoalphalipoproteinemia, or high density... (604091) more...

NIH Rare Diseases:47 Familial HDL deficiency is a rare genetic condition that causes low levels of good cholesterol (HDL) in the blood. HDL helps remove excess cholesterol and fats from your blood. People with familial HDL deficiency may develop cardiovascular disease at a relatively young age, often before age 50. This condition is caused by changes in the ABCA1 or the APOA1 genes. The deficiency is passed through families in an autosomal dominant pattern. More severely reduced levels of HDL in the blood is a characteristic feature of a related disorder called Tangier disease. Last updated: 1/19/2016

Wikipedia:70 Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant... more...

Related Diseases for Hypoalphalipoproteinemia

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Diseases related to Hypoalphalipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1obesity28.1APOA1, APOB, APOE, LCAT, LIPC, LPL
2coronary artery disease26.3ABCA1, APOA1, APOA2, APOB, APOC3, APOE
3tangier disease11.8
4hypertriglyceridemia11.2
5hypolipoproteinemia10.8
6intellectual disability-developmental delay-contractures syndrome10.6APOA1, LCAT
7atp1a3-related neurologic disorders10.6APOE, LPL
8spondylometaphyseal dysplasia, megarbane-dagher-melike type10.5LIPC, LPL
9tyrosinemia, type ii10.4APOA1, APOA2, LCAT
10lipoprotein glomerulopathy10.4APOE, LCAT
11amyoplasia mandibulofacial dysostosis10.4APOA1, APOA2
12c1s deficiency10.4APOE, LPL
13afibrinogenemia, congenital10.3APOA1, APOA2, LPA
14amelogenesis imperfecta, type iia310.3APOA1, APOE, LIPC, LPL
15malignant parietal pleura tumor10.2GGT1, LCAT
16dysmorphism-pectus carinatum-joint laxity syndrome10.2APOB, APOE
17conjunctival disease10.2APOA1, APOE, CETP, LPL
18respiratory syncytial virus infectious disease10.2APOE, LPA
19fetal methyl mercury syndrome10.1APOA1, APOB, LCAT
20dyserythropoietic anemia, congenital, type ii10.1APOA1, APOC3, LCAT, LPA
21intravascular angioleiomyoma10.0APOE, SLC25A20
22shwachman-diamond type metaphyseal dysplasia10.0APOA1, APOB
23dermal unilateral segmental cavernous angioma10.0APOB, APOE, LPA
24angina pectoris9.9APOA1, APOB, LPA
25blue toe syndrome9.9APOB, LCAT, LIPC, LPL
26artery disease9.9
27pontocerebellar hypoplasia9.9APOA1, APOB, APOE, CETP
28posterior foramen magnum meningioma9.9APOA1, APOB, GBA
29hemochromatosis, type 59.8ABCA1, APOE, LDLR
30fish-eye disease9.8
31atherosclerosis9.8
32hepatitis9.8
33heart disease9.8
34eye disease9.8
35glossopharyngeal nerve neoplasm9.8APOA1, APOB, APOE, LPA
36casr-related disorders9.8APOB, APOE, PPARA
37tracheal calcification9.8APOA1, APOB, PPARA
38littre gland carcinoma9.8APOA1, APOB, APOE, LPA
39breast cancer9.8
40pertussis9.8
41amenorrhea9.8
42sporadic breast cancer9.8
43islet cell tumor9.7ABCA1, APOA1, APOB, APOE, LPL
44angiomatous meningioma9.7APOB, LPL, PPARA
45survival motor neuron spinal muscular atrophy9.7APOA1, APOB, PPARA
46hepatic lipase deficiency9.7
47hyperalphalipoproteinemia9.7
48amyloidosis9.7
49hyperhomocysteinemia9.7
50endotheliitis9.7

Graphical network of the top 20 diseases related to Hypoalphalipoproteinemia:



Diseases related to hypoalphalipoproteinemia

Symptoms for Hypoalphalipoproteinemia

About this section


Clinical features from OMIM:

604091

Human phenotypes related to Hypoalphalipoproteinemia:

 63 53 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 multiple lipomas63 hallmark (90%) HP:0001012
2 coronary artery disease63 hallmark (90%) HP:0001677
3 cerebral ischemia63 hallmark (90%) HP:0002637
4 abnormality of lipid metabolism63 hallmark (90%) HP:0003119
5 opacification of the corneal stroma63 hallmark (90%) HP:0007759
6 abnormality of the liver63 53 typical (50%) Frequent (79-30%) HP:0001392
7 splenomegaly63 53 typical (50%) Frequent (79-30%) HP:0001744
8 anemia63 53 typical (50%) Frequent (79-30%) HP:0001903
9 lymphadenopathy63 53 typical (50%) Frequent (79-30%) HP:0002716
10 emg abnormality63 53 typical (50%) Frequent (79-30%) HP:0003457
11 hemiplegia/hemiparesis63 53 typical (50%) Frequent (79-30%) HP:0004374
12 sudden cardiac death63 occasional (7.5%) HP:0001645
13 hypoalphalipoproteinemia63 53 Frequent (79-30%) HP:0003233
14 blurred vision53 Frequent (79-30%)
15 xanthomatosis53 Frequent (79-30%)
16 corneal opacity53 Frequent (79-30%)

Drugs & Therapeutics for Hypoalphalipoproteinemia

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Drugs for Hypoalphalipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotinamideapproved, NutraceuticalPhase 490298-92-0936
Synonyms:
.beta.-Pyridinecarboxamide
11032-50-1
123574-63-0
1yc5
3 Pyridinecarboxamide
3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
37321-14-5
47865U_SUPELCO
55600-01-6
63748-44-7
72340_FLUKA
72340_SIGMA
72347_FLUKA
78731-47-2
98-92-0
A186B02E-6C70-4E54-9739-79398D439AAA
AC-907/25014114
AC1L1ACZ
AC1Q4ZFV
AI3-02906
Acid amide
Amid kyseliny nikotinove
Amid kyseliny nikotinove [Czech]
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Astra Brand of Niacinamide
Austrovit PP
B 3, Vitamin
B3, Vitamin
BB_NC-2290
Benicot
C00153
C6H6N2O
CCRIS 1901
CHEBI:17154
CHEMBL1140
CID936
CPD000058212
D00036
D009536
DB02701
DEA No. 1405
Delonin Amide
Delonin amide
Dipegyl
Dipigyl
EINECS 202-713-4
EINECS 234-265-0
Endobion
Enduramide
Factor pp
HMS2052M21
HMS2090B05
HMS2093H03
HSDB 1237
Hansamid
I02-1741
I02-2250
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Inovitan PP
Jenapharm Brand of Niacinamide
Jenapharm, Nicotinsaureamid
LS-2051
MLS000069714
Mediatric
Merck Brand of Niacinamide
MolMap_000061
MolPort-001-783-876
N0078
N0636_SIGMA
N2142_SIGMA
N3376_SIGMA
N5535_SIAL
NAM
NCGC00093354-03
NCGC00093354-04
NSC 13128
NSC13128
NSC27452
Nandervit-N
Niacevit
Niacinamide
Niacinamide (USP)
Niacinamide Astra Brand
Niacinamide Jenapharm Brand
Niacinamide Merck Brand
 
Niacinamide Pharmagenix Brand
Niacinamide [USAN]
Niacinamide, Nicotinic acid amide, Nicotinamide
Niacotinamide
Niamide
Niavit PP
Nicamide
Nicamina
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicosylamide
Nicota
Nicotamide
Nicotilamide
Nicotililamido
Nicotinamid
Nicotinamida
Nicotinamida [INN-Spanish]
Nicotinamide
Nicotinamide (JP15/INN)
Nicotinamide (Niacinamide)
Nicotinamide, niacin, vitamin B3
Nicotinamide-carbonyl-14C
Nicotinamidum
Nicotinamidum [INN-Latin]
Nicotine acid amide
Nicotine amide
Nicotinic acid amide
Nicotinic amide
Nicotinsaeureamid
Nicotinsaureamid
Nicotinsaureamid Jenapharm
Nicotinsaureamid [German]
Nicotol
Nicotylamide
Nicotylamidum
Nicovel
Nicovit
Nicovitina
Nicovitol
Nicozymin
Nictoamide
Nikasan
Nikazan
Niko-tamin
Nikotinamid
Nikotinsaeureamid
Nikotinsaeureamid [German]
Niocinamide
Niozymin
PP-Faktor
Papulex
Pelmin
Pelmine
Pelonin amide
Pharmagenix Brand of Niacinamide
Propamine A
Pyridine-3-carboxylic acid amide
S1899_Selleck
SAM001246860
SGCUT00176
SMR000058212
Savacotyl
UNII-25X51I8RD4
Vi-Nicotyl
Vi-noctyl
Vitamin B
Vitamin B (VAN)
Vitamin B 3
Vitamin B3 amide
Vitamin H1
Vitamin PP
WLN: T6NJ CVZ
Witamina PP
ZINC00005878
b-Pyridinecarboxamide
beta-Pyridinecarboxamide
bmse000281
m-(Aminocarbonyl)pyridine
nchembio.154-comp4
nchembio.73-comp6
niacin - Vitamin B3
niacinamide
nicotinamide
pyridine-3-carboxamide
to_000073
vitamin PP
2
Folic Acidapproved, nutraceutical, vet_approvedPhase 4427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
3
Niacinapproved, investigational, nutraceuticalPhase 490659-67-6938
Synonyms:
3-Carboxylpyridine
3-Carboxypyridine
3-Pyridinecarboxylate
3-Pyridinecarboxylic acid
3-Pyridylcarboxylate
3-Pyridylcarboxylic acid
3-carboxypyridine
Acide Nicotinique
Acido nicotinico
Acidum Nicotinicum
Akotin
Anti-pellagra vitamin
Apelagrin
Daskil
Efacin
Enduracin
Linic
M-Pyridinecarboxylic Acid
Niac
Niacin
Niacine
Niacor
Nicacid
Nicamin
Nicangin
 
Nico-Span
Nicobid
Nicocap
Nicodelmine
Nicolar
Niconacid
Nicosan 3
Nicotinate
Nicotinic Acid
Nicotinic acid
Nicotinipca
Nicyl
Nikotinsaeure
Nyclin
P.P. factor
PP Factor
Pellagra preventive factor
Pellagrin
Pelonin
Pyridine-beta-carboxylic acid
Slo-niacin
Vitamin B3
Wampocap
beta-Pyridinecarboxylic acid
pyridine-β-carboxylic acid
β-pyridinecarboxylic acid
4Trace ElementsPhase 45802
5Vasodilator AgentsPhase 43438
6Vitamin B ComplexPhase 44229
7AntimetabolitesPhase 411774
8Nicotinic AcidsPhase 4906
9VitaminsPhase 45095
10MicronutrientsPhase 45802
11Hypolipidemic AgentsPhase 42721
12Lipid Regulating AgentsPhase 42702
13Vitamin B9NutraceuticalPhase 44279
14Vitamin B3NutraceuticalPhase 4906
15FolateNutraceuticalPhase 44279
16
Fenofibrateapproved16949562-28-93339
Synonyms:
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
49562-28-9
AB00052196
AC-4227
AC1L1FPK
AKOS005107777
AZU, Fenofibrat
AbZ Brand of Procetofen
Abbott Brand of Procetofen
Aliud Brand of Procetofen
Ankebin
Antara
Antara (TN)
Antara (micronized)
Antara Micronized Procetofen
Anto Brand of Procetofen
Apo Feno Micro
Apo Fenofibrate
Apo-Feno-Micro
Apo-Fenofibrate
Apotex Brand of Procetofen
Azupharma Brand of Procetofen
BIDD:GT0574
BPBio1_000166
BRD-K50388907-001-05-6
BRN 2062462
BSPBio_000150
BSPBio_003162
Bouchara Brand of Procetofen
C07586
C20H21ClO4
CAS-49562-28-9
CCRIS 7282
CHEBI:5001
CHEMBL672
CID3339
CIP-Fenofibrate
CPD000058299
Controlip
D00565
D011345
DB01039
Debat, Fenofibrate
DivK1c_000557
EINECS 256-376-3
EU-0100486
Elasterate
Elasterin
F 6020
F6020_SIGMA
FENOFIBRATE (MICRONIZED)
FNF
Fenobeta
Fenobrate
Fenofanton
Fenofibrat AL
Fenofibrat AZU
Fenofibrat AbZ
Fenofibrat FPh
Fenofibrat Heumann
Fenofibrat Hexal
Fenofibrat Stada
Fenofibrat ratiopharm
Fenofibrat-ratiopharm
Fenofibrate
Fenofibrate (JAN/INN)
Fenofibrate Debat
Fenofibrate IDD-P
Fenofibrate MSD
Fenofibrate [INN:BAN]
Fenofibrato
Fenofibrato [INN-Spanish]
Fenofibratum
Fenofibratum [INN-Latin]
Fenofibric acid
Fenogal
Fenoglide
Fenomax
Fenotard
Finofibrate
Fournier Brand of Procetofen
Fulcro
GNR Pharma Brand of Procetofen
GNR-Pharma Brand of Procetofen
GRS-027
Gate Brand of Procetofen
Gen Fenofibrate
Gen-Fenofibrate
Genpharm Brand of Procetofen
HMS1568H12
HMS1921B17
HMS2090G20
HMS2092B05
HMS501L19
Heumann Brand of Procetofen
Heumann, Fenofibrat
Hexal Brand of Procetofen
Hexal, Fenofibrat
I06-0048
IDI1_000557
Isopropyl (4'-(P-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
KBio1_000557
KBio2_001730
KBio2_004298
KBio2_006866
KBio3_002382
KBioGR_000706
KBioSS_001730
Knoll Brand of Procetofen
LCP-Feno
LCP-FenoChol
LF 178
 
LF-178
LF178
LS-121256
Lichtenstein Brand of Procetofen
Lipanthyl
Lipantil
Lipantil (TN)
Liparison
Lipidex
Lipidil
Lipidil Micro
Lipidil Supra
Lipidil Ter
Lipidil-Ter
Lipifen
Lipirex
Lipoclar
Lipofen
Lipofen (TN)
Lipofene
Liposit
Lipsin
Lofibra
Lopac-F-6020
Lopac0_000486
Luxacor
MLS000028515
MLS001148191
MTW Brand of Procetofen
MTW Fenofibrat
MTW-Fenofibrat
Merck dura Brand of Procetofen
Micronized Procetofen, Antara
MolPort-002-887-051
NCGC00015437-01
NCGC00015437-02
NCGC00015437-03
NCGC00015437-06
NCGC00015437-12
NCGC00021475-03
NCGC00021475-04
NCGC00021475-05
NCGC00021475-06
NCGC00021475-07
NCGC00021475-08
NINDS_000557
NSC 281319
NSC281319
Nolipax
Novartis Brand of Procetofen
Novo Fenofibrate
Novo-Fenofibrate
Novopharm Brand of Procetofen
Nu Fenofibrate
Nu Pharm Brand of Procetofen
Nu-Fenofibrate
Nu-Pharm Brand of Procetofen
PMS Fenofibrate Micro
PMS-Fenofibrate Micro
Pharmascience Brand of Procetofen
Pharmavit
Phenofibrate
Prestwick0_000275
Prestwick1_000275
Prestwick2_000275
Prestwick3_000275
Prestwick_217
Procetofen
Procetofen Reliant Brand
Procetofen, Antara Micronized
Procetofene
Proctofene
Protolipan
Q Pharm Brand of Procetofen
Q-Pharm Brand of Procetofen
Reliant Brand of Procetofen
S1794_Selleck
SAM002264613
SMR000058299
SPBio_001380
SPBio_002369
SPECTRUM1501010
ST085313
Schering Plough Brand of Procetofen
Schering-Plough Brand of Procetofen
Secalip
Sedufen
Spectrum2_001390
Spectrum3_001431
Spectrum4_000413
Spectrum5_001479
Spectrum_001250
Stada, Fenofibrat
Stadapharm Brand of Procetofen
Supralip
TL8003296
TRICOR (MICRONIZED)
Tricor
Tricor (TN)
Triglide
Triglide (TN)
Trilipix
UNII-U202363UOS
United Drug Brand of Procetofen
ZINC00584092
betapharm Brand of Procetofen
ct Arzneimittel Brand of Procetofen
ct-Arzneimittel Brand of Procetofen
durafenat
fenofibrat von ct
fenofibrate
fenofibric acid
isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
nchembio790-comp24
ratiopharm Brand of Procetofen
17
Adenosineapproved, investigational39758-61-760961
Synonyms:
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
1odi
2fqy
2gl0
30143-02-3
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
A0152
A4036_SIGMA
A9251_SIGMA
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ADN
AI3-52413
Ade-Rib
Ade-rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine deoxyribonucleoside
Adenine nucleoside
Adenine riboside
Adenine-9-beta-D-ribofuranoside
Adenine-9beta-D-Ribofuranoside
Adenine-9beta-delta-Ribofuranoside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine, homopolymer
Adenosinum
Adensoine
Adenyldeoxyriboside
Ado
Adénosine
BB_NC-0565
BSPBio_001796
Bio1_000437
 
Bio1_000926
Bio1_001415
Boniton
C00212
CCRIS 2557
CHEBI:16335
CHEMBL477
CID60961
Caswell No. 010B
D000241
D00045
DB00640
Deoxyadenosine
Desoxyadenosine
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
FT-0082881
HMS1920A13
HMS2091G13
KBio3_001296
LS-15085
MEDR-640
MLS000069638
MLS002153227
MolPort-001-838-229
Myocol
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NSC 627048
NSC 7652
NSC627048
NSC7652
Nucleocardyl
Pallacor
Polyadenosine
Polyriboadenosine
S1647_Selleck
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
SR 96225
SR-96225
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum3_000288
TL8003749
UNII-K72T3FS567
USAF CB-10
V0098
Vidarabine
ZINC02169830
adenine-D-ribose
adenosine
b-D-Adenosine
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.2007.56-comp13
nchembio.64-comp4
nchembio706-5
18Clofibric Acid21882-09-7
19Hydroxymethylglutaryl-CoA Reductase Inhibitors1956
20Calcium, Dietary5525
21Atorvastatin Calcium743134523-03-8
22Anticholesteremic Agents1983
23Pharmaceutical Solutions7793
24TomatoNutraceutical52
25
LycopeneNutraceutical57502-65-8446925
Synonyms:
(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene
(all-E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene
All-trans-Lycopene
 
Lyco Vit
Lycopene
Lycopene 7
trans-Lycopene

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Short-term Effect of Extended-release Niacin on Endothelial Function.CompletedNCT01942291Phase 4
2Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese ChildrenCompletedNCT01886495Phase 3
3Effect of High Protein Diet on Cardiovascular Diseases Risk Factors Among Overweight and Obese ChildrenCompletedNCT01886482Phase 3
4High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese WomenCompletedNCT01763528Phase 3
5CER-001 Therapy as a Novel Approach to Treat Genetic Orphan DiseasesRecruitingNCT02697136Phase 3
6Tomato Consumption and High Density Lipoprotein-cholesterolCompletedNCT01342666
7High-Density Lipoprotein (HDL) Treatment StudyCompletedNCT00458055
8Quantitative Genetic Analysis of Lipid Research Clinic Family DataCompletedNCT00005188
9Peripheral Arterial Insufficiency Associated With HIV/AIDSCompletedNCT02264509
10Evaluation of LipoproteinsRecruitingNCT00001168
11Causes and Natural History of DyslipidemiasRecruitingNCT00353782
12Mendelian Reverse Cholesterol Transport StudyActive, not recruitingNCT01782027

Search NIH Clinical Center for Hypoalphalipoproteinemia

Genetic Tests for Hypoalphalipoproteinemia

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Genetic tests related to Hypoalphalipoproteinemia:

id Genetic test Affiliating Genes
1 Familial Hypoalphalipoproteinemia26
2 Hypoalphalipoproteinemia26

Anatomical Context for Hypoalphalipoproteinemia

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MalaCards organs/tissues related to Hypoalphalipoproteinemia:

35
Liver, Heart, Endothelial, Eye, Kidney, Monocytes

Animal Models for Hypoalphalipoproteinemia or affiliated genes

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MGI Mouse Phenotypes related to Hypoalphalipoproteinemia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0ABCA1, APOB, APOE, GGT1, LDLR
2MP:00053798.3ABCA1, APOA1, APOE, GBA, GGT1, LCAT
3MP:00053698.2ABCA1, APOB, APOE, LDLR, LPL, PPARA
4MP:00053917.8ABCA1, APOB, APOE, GGT1, LCAT, LDLR
5MP:00107717.8APOA1, APOE, GBA, GGT1, LDLR, LPL
6MP:00053707.8ABCA1, APOA1, APOB, APOE, GBA, LCAT
7MP:00053857.5ABCA1, APOA1, APOB, APOE, GBA, LCAT
8MP:00053765.8ABCA1, APOA1, APOA2, APOB, APOE, GBA

Publications for Hypoalphalipoproteinemia

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Articles related to Hypoalphalipoproteinemia:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Targeted Proteomics Identifies Paraoxonase/Arylesterase 1 (PON1) and Apolipoprotein Cs as Potential Risk Factors for Hypoalphalipoproteinemia in Diabetic Subjects Treated with Fenofibrate and Rosiglitazone. (26667175)
2016
2
Prevalence of classical CD14++/CD16- but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia. (23623664)
2013
3
An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. (21575609)
2011
4
Multiple splice defects in ABCA1 cause low HDL-C in a family with hypoalphalipoproteinemia and premature coronary disease. (19133158)
2009
5
Acquired severe hypercholesterolemia and hypoalphalipoproteinemia. (21291840)
2009
6
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. (16957769)
2007
7
Genetically based hypertension generated through interaction of mild hypoalphalipoproteinemia and mild hyperhomocysteinemia. (17620955)
2007
8
Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. (16225879)
2006
9
Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. (16388083)
2006
10
Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. (16127020)
2005
11
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. (15841208)
2005
12
C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. (15562377)
2005
13
Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. (15292235)
2004
14
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. (12700344)
2003
15
Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease. (12813037)
2003
16
Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia. (12048121)
2002
17
Increased plasma C-reactive protein in familial hypoalphalipoproteinemia: a proinflammatory condition? (11772869)
2002
18
ApoA-I(MALLORCA) impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia. (11792730)
2002
19
Corticosteroid therapy increases HDL-cholesterol concentrations in patients with active sarcoidosis and hypoalphalipoproteinemia. (11983201)
2002
20
Lecithin:cholesterol acyl transferase G30S: association with atherosclerosis, hypoalphalipoproteinemia and reduced in vivo enzyme activity. (11522275)
2001
21
Improvement in endothelial dysfunction in patients with hypoalphalipoproteinemia and coronary artery disease treated with bezafibrate. (11483875)
2001
22
Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. (10716466)
2000
23
Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease. (10551691)
1999
24
Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey. (9931341)
1999
25
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. (9851961)
1998
26
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase. (9717715)
1998
27
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
28
Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease. (8883496)
1996
29
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia. (7712672)
1995
30
Concentrations of apolipoprotein A-I-containing particles in patients with hypoalphalipoproteinemia. (8148349)
1994
31
Familial hypoalphalipoproteinemia in premature coronary artery disease. (8241092)
1993
32
Low levels of high-density lipoprotein cholesterol (hypoalphalipoproteinemia). An approach to management. (8323418)
1993
33
A case report: familial hypoalphalipoproteinemia. (8348223)
1993
34
Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene. (8240372)
1993
35
Hypoalphalipoproteinemia. (1458423)
1992
36
Postprandial lipoprotein(a) response to a single meal containing either saturated or omega-3 polyunsaturated fatty acids in subjects with hypoalphalipoproteinemia. (1461142)
1992
37
Delayed clearance of postprandial chylomicrons and their remnants in the hypoalphalipoproteinemia and mild hypertriglyceridemia syndrome. (1390590)
1992
38
Analysis of familial hypoalphalipoproteinemia syndromes. (1518505)
1992
39
Familial hypoalphalipoproteinemia: definition of two groups based on plasma triglyceride levels. (2638523)
1989
40
Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. (2810673)
1989
41
Insufficient evidence to invoke defects in or around the A-I gene as the cause for familial hypoalphalipoproteinemia. (3118895)
1987
42
A major gene for primary hypoalphalipoproteinemia. (3953576)
1986
43
A family study of hypoalphalipoproteinemia. (3541526)
1986
44
Severe hypoalphalipoproteinemia induced by a combination of probucol and clofibrate. (3541510)
1986
45
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. (3081805)
1986
46
Restriction-fragment-length polymorphisms in the A-I-C-III gene complex occurring in a family with hypoalphalipoproteinemia. (2877676)
1986
47
Familial hypoalphalipoproteinemia. (3541525)
1986
48
A genetic study of hypoalphalipoproteinemia. (6544231)
1984
49
Primary and familial hypoalphalipoproteinemia. (6694557)
1984
50
Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism. (7231186)
1981

Variations for Hypoalphalipoproteinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hypoalphalipoproteinemia:

69
id Symbol AA change Variation ID SNP ID
1ABCA1p.Met1091ThrVAR_012628
2ABCA1p.Pro2150LeuVAR_012636rs369098049
3ABCA1p.Pro85LeuVAR_017529rs145183203
4ABCA1p.Asp1099TyrVAR_017530rs28933692
5ABCA1p.Phe2009SerVAR_037971rs137854499

Clinvar genetic disease variations for Hypoalphalipoproteinemia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1APOA1APOA1, 1-BP INSinsertionPathogenicChr na, -1: -1
2APOA1APOA1, IVS2, G-C, +1SNVPathogenicChr na, -1: -1
3ABCA1NM_005502.3(ABCA1): c.2080_2082delCTT (p.Leu694del)deletionPathogenicrs387906412GRCh37Chr 9, 107591230: 107591232
4ABCA1NM_005502.3(ABCA1): c.3295G> T (p.Asp1099Tyr)SNVPathogenicrs28933692GRCh37Chr 9, 107581111: 107581111
5ABCA1NM_005502.3(ABCA1): c.6026T> C (p.Phe2009Ser)SNVPathogenicrs137854499GRCh37Chr 9, 107550750: 107550750
6ABCA1NM_005502.3(ABCA1): c.3847_3850delCGCC (p.Pro1284Serfs)deletionPathogenicrs387906415GRCh37Chr 9, 107576450: 107576453

Expression for genes affiliated with Hypoalphalipoproteinemia

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Search GEO for disease gene expression data for Hypoalphalipoproteinemia.

Pathways for genes affiliated with Hypoalphalipoproteinemia

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Pathways related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.9ABCA1, APOA1, APOA2
2
Show member pathways
9.8ABCA1, APOA1, APOE
3
Show member pathways
9.6LIPC, LPL, SLC25A20
4
Show member pathways
9.6ABCA1, APOA1, APOB
5
Show member pathways
9.5APOA1, APOB, APOE
68.8ABCA1, LDLR, PPARA
78.4APOA1, APOA2, APOC3, LPL, PLTP, PPARA
8
Show member pathways
8.1APOA1, APOA2, APOB, APOC3, APOE, LDLR
9
Show member pathways
8.1APOA1, APOA2, APOB, APOC3, APOE, LDLR
10
Show member pathways
8.0ABCA1, APOA1, APOA2, LPL, PPARA, RORA
11
Show member pathways
6.9ABCA1, APOA1, APOA2, APOB, APOC3, APOE
12
Show member pathways
6.6ABCA1, APOA1, APOA2, APOB, APOC3, APOE
13
Show member pathways
4.1ABCA1, APOA1, APOA2, APOB, APOC3, APOE

GO Terms for genes affiliated with Hypoalphalipoproteinemia

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Cellular components related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1spherical high-density lipoprotein particleGO:003436610.4APOA1, APOA2, APOC3
2endocytic vesicle lumenGO:007168210.2APOA1, APOB, APOE
3intermediate-density lipoprotein particleGO:003436310.1APOB, APOC3, APOE
4low-density lipoprotein particleGO:00343629.8APOB, APOE, LDLR
5endoplasmic reticulum lumenGO:00057889.7APOA1, APOA2, APOB, LIPC
6high-density lipoprotein particleGO:00343649.6ABCA1, APOA1, APOA2, APOE, CETP, LCAT
7chylomicronGO:00426279.5APOA1, APOA2, APOB, APOC3, APOE, LPL
8very-low-density lipoprotein particleGO:00343619.4APOA1, APOA2, APOB, APOC3, APOE, LPL
9cell surfaceGO:00099869.1ABCA1, APOA1, LDLR, LIPC, LPL
10early endosomeGO:00057698.5APOA1, APOA2, APOB, APOC3, APOE, LDLR
11extracellular regionGO:00055767.6APOA1, APOA2, APOB, APOC3, APOE, CETP
12extracellular exosomeGO:00700627.3APOA1, APOA2, APOB, APOC3, APOE, CETP
13extracellular spaceGO:00056156.8APOA1, APOA2, APOB, APOC3, APOE, CETP

Biological processes related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1protein oxidationGO:001815810.8APOA1, APOA2
2regulation of intestinal cholesterol absorptionGO:003030010.8APOA1, APOA2
3negative regulation of lipase activityGO:006019210.7APOA1, APOA2
4peptidyl-methionine modificationGO:001820610.7APOA1, APOA2
5chylomicron remodelingGO:003437110.7LIPC, LPL
6negative regulation of cytokine secretion involved in immune responseGO:000274010.7APOA1, APOA2
7negative regulation of cholesterol importGO:006062110.7APOA2, APOC3
8neuron projection regenerationGO:003110210.6APOA1, APOE
9phosphatidylcholine metabolic processGO:004647010.6CETP, LCAT
10negative regulation of very-low-density lipoprotein particle remodelingGO:001090310.5APOA1, APOA2, APOC3
11positive regulation of cholesterol esterificationGO:001087310.4APOA1, APOA2, APOE
12high-density lipoprotein particle clearanceGO:003438410.4APOA1, APOA2, APOE
13phosphatidylcholine biosynthetic processGO:000665610.4APOA1, APOA2, LCAT
14phospholipid homeostasisGO:005509110.4ABCA1, APOA1, CETP
15phospholipid metabolic processGO:000664410.4APOA1, LCAT, LPL
16positive regulation of cholesterol effluxGO:001087510.4ABCA1, APOE, PLTP
17chylomicron remnant clearanceGO:003438210.3APOC3, APOE, LIPC
18positive regulation of cholesterol storageGO:001088610.3APOB, LPL
19cholesterol importGO:007050810.2APOA1, LDLR
20high-density lipoprotein particle assemblyGO:003438010.2ABCA1, APOA1, APOA2, APOE
21regulation of cholesterol homeostasisGO:200018810.2LDLR, RORA
22regulation of Cdc42 protein signal transductionGO:003248910.2ABCA1, APOA1, APOC3, APOE
23negative regulation of cholesterol storageGO:001088710.1ABCA1, PPARA
24response to estrogenGO:004362710.1APOA1, APOA2, GBA
25very-low-density lipoprotein particle assemblyGO:003437910.1APOB, APOC3
26phospholipid effluxGO:003370010.0ABCA1, APOA1, APOA2, APOC3, APOE
27lipid transportGO:00068699.9APOA2, CETP, LPA, PLTP
28response to glucocorticoidGO:00513849.9APOA2, GBA, LCAT, LIPC
29very-low-density lipoprotein particle remodelingGO:00343729.8APOE, CETP, LCAT, LIPC, LPL
30phospholipid transportGO:00159149.8ABCA1, APOA1, CETP, LDLR
31negative regulation of macrophage derived foam cell differentiationGO:00107459.7ABCA1, CETP, PPARA
32lipoprotein catabolic processGO:00421599.6APOB, APOE, LDLR
33triglyceride metabolic processGO:00066419.6APOA2, APOC3, APOE, CETP, LPL
34low-density lipoprotein particle remodelingGO:00343749.5APOA2, APOB, APOE, CETP, LIPC
35low-density lipoprotein particle clearanceGO:00343839.5APOB, LDLR, LIPC
36lipoprotein biosynthetic processGO:00421589.5ABCA1, APOA1, APOA2, APOB, APOE, LCAT
37triglyceride homeostasisGO:00703289.4APOA1, APOC3, CETP, LIPC, LPL, RORA
38cholesterol effluxGO:00333449.4ABCA1, APOA1, APOA2, APOB, APOC3, APOE
39reverse cholesterol transportGO:00436919.1ABCA1, APOA1, APOA2, APOC3, APOE, CETP
40response to drugGO:00424939.1ABCA1, APOA1, APOA2, APOC3, LIPC, LPL
41high-density lipoprotein particle remodelingGO:00343759.1APOA1, APOA2, APOC3, APOE, CETP, LCAT
42triglyceride catabolic processGO:00194339.0APOA1, APOB, APOC3, APOE, LIPC, LPL
43retinoid metabolic processGO:00015238.9APOA1, APOA2, APOB, APOC3, APOE, LPL
44negative regulation of inflammatory responseGO:00507288.9APOA1, APOE, GBA, PPARA, RORA
45receptor-mediated endocytosisGO:00068988.7APOA1, APOB, APOE, CETP, LDLR
46cholesterol transportGO:00303018.6ABCA1, APOA1, APOA2, APOB, CETP, LCAT
47cholesterol metabolic processGO:00082038.0ABCA1, APOA1, APOA2, APOB, APOE, CETP
48lipid metabolic processGO:00066297.9APOB, APOE, LDLR, LPA, PLTP, PPARA
49cholesterol homeostasisGO:00426327.5ABCA1, APOA1, APOA2, APOB, APOC3, APOE
50lipoprotein metabolic processGO:00421576.8ABCA1, APOA1, APOA2, APOB, APOC3, APOE

Molecular functions related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I bindingGO:003418610.7ABCA1, LCAT
2apolipoprotein receptor bindingGO:003419010.7APOA1, APOA2
3high-density lipoprotein particle bindingGO:000803510.5APOA1, APOA2
4lipoprotein particle bindingGO:007181310.5APOA1, APOE
5triglyceride bindingGO:001712910.4CETP, LPL
6high-density lipoprotein particle receptor bindingGO:007065310.4APOA1, APOA2, APOC3
7lipase inhibitor activityGO:005510210.4APOA1, APOA2, APOC3
8phosphatidylcholine-sterol O-acyltransferase activator activityGO:006022810.4APOA1, APOA2, APOE
9phosphatidylcholine bindingGO:003121010.3APOA1, APOA2, CETP
10phospholipid transporter activityGO:000554810.2ABCA1, APOA1, CETP
11phospholipase activityGO:000462010.2LIPC, LPL
12triglyceride lipase activityGO:000480610.2LIPC, LPL
13apolipoprotein bindingGO:003418510.0ABCA1, LIPC, LPA, LPL
14low-density lipoprotein particle bindingGO:003016910.0LDLR, LIPC
15lipid transporter activityGO:000531910.0APOA1, APOA2, APOE, CETP
16transcription coactivator bindingGO:00012239.8PPARA, RORA
17low-density lipoprotein particle receptor bindingGO:00507509.7APOB, APOE
18cholesterol bindingGO:00154859.5ABCA1, APOA1, APOA2, APOC3, APOE, CETP
19cholesterol transporter activityGO:00171279.2ABCA1, APOA1, APOA2, APOB, APOE, CETP
20heparin bindingGO:00082019.1APOB, APOE, LIPC, LPA, LPL
21phospholipid bindingGO:00055438.8ABCA1, APOA1, APOA2, APOB, APOC3, APOE
22lipid bindingGO:00082897.4APOA1, APOA2, APOB, APOE, CETP, LIPC

Sources for Hypoalphalipoproteinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet