MCID: HYP121
MIFTS: 52

Hypoalphalipoproteinemia malady

Genetic diseases (common) category
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Summaries for Hypoalphalipoproteinemia

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Wikipedia:65 Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant... more...

MalaCards based summary: Hypoalphalipoproteinemia is related to fish-eye disease and hepatic lipase deficiency, and has symptoms including An important gene associated with Hypoalphalipoproteinemia is APOA1 (apolipoprotein A-I), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Fat digestion and absorption. The compounds psyllium and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and kidney, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Description from OMIM:46 604091

Aliases & Classifications for Hypoalphalipoproteinemia

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Sources:
46OMIM, 44Novoseek
See all sources

Hypoalphalipoproteinemia, Aliases & Descriptions:

Name: Hypoalphalipoproteinemia 46 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Hypoalphalipoproteinemia

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Diseases related to Hypoalphalipoproteinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease30.8LCAT, APOA2, APOA1
2hepatic lipase deficiency30.7LIPC
3familial hypercholesterolemia30.4CETP, APOB, LDLR
4amyloidosis30.1APOA1, APOA2, LPA, LPL
5tangier disease29.5APOA1, ABCA1, PPARA, APOC3, APOA2, LCAT
6hyperalphalipoproteinemia29.4LIPC, APOB, APOA2, APOC3, APOA1, ABCA1
7hypertension29.1PPARA, APOA1, ACE, GGT1, APOB, LPA
8hypertriglyceridemia28.8GGT1, LCAT, PLTP, LPL, LPA, CETP
9hypercholesterolemia28.5PPARA, GGT1, LCAT, ACE, LPL, LPA
10obesity28.3LPL, LPA, CETP, LDLR, LIPC, APOB
11atherosclerosis27.6LPL, CETP, LCAT, PLTP, ACE, LPA
12cerebral atherosclerosis10.5APOA1
13familial hdl deficiency10.4
14chylomicron retention disease10.4APOB
15gallbladder disease10.4GGT1
16amyloidosis, renal10.4APOA2, APOA1
17lipase deficiency combined10.3LPL, LIPC
18familial combined hyperlipidemia10.3APOB, APOA1
19arcus senilis10.3APOA1, APOB, LCAT
20familial hypertriglyceridemia10.3APOC3, APOB, LPL
21artery disease10.2
22splenomegaly10.2GBA, ABCA1, LCAT
23amyloidosis, secondary10.2LPA, APOA1, LCAT
24hypobetalipoproteinemia10.2LCAT, APOA1, APOB, LDLR
25alagille syndrome10.2APOA1, LPA, LCAT
26polycystic ovary syndrome10.2APOA1, LIPC, PPARA
27xanthomatosis10.2ABCA1, LDLR, LPL, APOB
28glucose intolerance10.2LPL, APOB, PPARA
29complete lcat deficiency10.2APOA1, LCAT, LPA, APOA2
30arteriosclerosis10.1APOB, LDLR, APOA1, LPL
31hepatitis10.1
32eye disease10.1
33hypothyroidism10.1APOB, CETP, LPA
34norum disease10.1APOA2, APOA1, LCAT, LPL, APOB
35idiopathic edema10.1ACE, PPARA
36abetalipoproteinemia10.1LCAT, CETP, APOB, APOA1, LPL
37hepatoblastoma10.1APOA1, LDLR, PPARA, APOA2, APOB
38hypertension, diastolic10.1ACE, GGT1
39hypertensive heart disease10.1ACE, PPARA
40galactosemia10.0SLC25A20, LDLR, GGT1
41cholestasis10.0GGT1, CETP, LIPC, LCAT
42lipodystrophy10.0PPARA, APOB, LDLR, LPL, APOC3
43hyperhomocysteinemia10.0
44sarcoidosis10.0
45endotheliitis10.0
46obstructive jaundice10.0LCAT, GGT1
47coronary stenosis10.0APOA1, CETP, LPA, LIPC, APOB
48hepatitis c10.0LDLR, GGT1, LIPC
49dementia9.9LPA, GBA, LPL, CETP
50stroke, ischemic9.9LPA, APOA1, ACE, APOB

Graphical network of the top 20 diseases related to Hypoalphalipoproteinemia:



Diseases related to hypoalphalipoproteinemia

Symptoms for Hypoalphalipoproteinemia

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Clinical features from OMIM:

604091

HPO human phenotypes related to Hypoalphalipoproteinemia:

(show all 6)
id Description Frequency HPO Source Accession
1 multiple lipomas hallmark (90%) HP:0001012
2 coronary artery disease hallmark (90%) HP:0001677
3 cerebral ischemia hallmark (90%) HP:0002637
4 abnormality of lipid metabolism hallmark (90%) HP:0003119
5 opacification of the corneal stroma hallmark (90%) HP:0007759
6 sudden cardiac death occasional (7.5%) HP:0001645

Drugs & Therapeutics for Hypoalphalipoproteinemia

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Drug clinical trials:

Search ClinicalTrials for Hypoalphalipoproteinemia

Search NIH Clinical Center for Hypoalphalipoproteinemia

Genetic Tests for Hypoalphalipoproteinemia

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Anatomical Context for Hypoalphalipoproteinemia

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MalaCards organs/tissues related to Hypoalphalipoproteinemia:

32
Eye, Heart, Kidney, Monocytes, Endothelial

Animal Models for Hypoalphalipoproteinemia or affiliated genes

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Publications for Hypoalphalipoproteinemia

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Articles related to Hypoalphalipoproteinemia:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Prevalence of classical CD14++/CD16- but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia. (23623664)
2013
2
Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity. (24322908)
2013
3
An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. (21575609)
2011
4
Acquired severe hypercholesterolemia and hypoalphalipoproteinemia. (21291840)
2009
5
Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment. (19280764)
2009
6
Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. (19616211)
2009
7
Genetically based hypertension generated through interaction of mild hypoalphalipoproteinemia and mild hyperhomocysteinemia. (17620955)
2007
8
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. (16957769)
2007
9
Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. (16388083)
2006
10
Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. (16225879)
2006
11
Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. (16127020)
2005
12
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. (15841208)
2005
13
C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. (15562377)
2005
14
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. (12700344)
2003
15
Increased plasma C-reactive protein in familial hypoalphalipoproteinemia: a proinflammatory condition? (11772869)
2002
16
Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia. (12048121)
2002
17
ApoA-I(MALLORCA) impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia. (11792730)
2002
18
Corticosteroid therapy increases HDL-cholesterol concentrations in patients with active sarcoidosis and hypoalphalipoproteinemia. (11983201)
2002
19
Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia. (11834535)
2002
20
Lecithin:cholesterol acyl transferase G30S: association with atherosclerosis, hypoalphalipoproteinemia and reduced in vivo enzyme activity. (11522275)
2001
21
Improvement in endothelial dysfunction in patients with hypoalphalipoproteinemia and coronary artery disease treated with bezafibrate. (11483875)
2001
22
Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations. (10998475)
2000
23
Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. (10775531)
2000
24
Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease. (10551691)
1999
25
Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. (10064737)
1999
26
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. (9851961)
1998
27
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
28
Genetic polymorphisms and mutations of the lipoprotein lipase gene in Japanese schoolchildren with hypoalphalipoproteinemia. (9730139)
1998
29
Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease. (8883496)
1996
30
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia. (7712672)
1995
31
Increase of gamma-glutamyltranspeptidase in patients with compensated hypoalphalipoproteinemia and type IIa dyslipidemias]. (7627821)
1995
32
Familial hypoalphalipoproteinemia in premature coronary artery disease. (8241092)
1993
33
Low levels of high-density lipoprotein cholesterol (hypoalphalipoproteinemia). An approach to management. (8323418)
1993
34
A case report: familial hypoalphalipoproteinemia. (8348223)
1993
35
Hypoalphalipoproteinemia: postprandial response of subjects with preprandial normotriglyceridemia and hypertriglyceridemia to various diets. (8474323)
1993
36
Hypoalphalipoproteinemia. (1458423)
1992
37
Analysis of familial hypoalphalipoproteinemia syndromes. (1518505)
1992
38
In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. (1619367)
1992
39
The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family. (1969839)
1990
40
Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. (2810673)
1989
41
Erythrocyte abnormalities in a hypoalphalipoproteinemia syndrome resembling fish eye disease. (3410011)
1988
42
Hypoalphalipoproteinemia resembling fish eye disease. (3591467)
1987
43
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. (3081805)
1986
44
Restriction-fragment-length polymorphisms in the A-I-C-III gene complex occurring in a family with hypoalphalipoproteinemia. (2877676)
1986
45
Familial hypoalphalipoproteinemia. (3541525)
1986
46
A major gene for primary hypoalphalipoproteinemia. (3953576)
1986
47
A family study of hypoalphalipoproteinemia. (3541526)
1986
48
A genetic study of hypoalphalipoproteinemia. (6544231)
1984
49
Primary and familial hypoalphalipoproteinemia. (6694557)
1984
50
Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism. (7231186)
1981

Variations for Hypoalphalipoproteinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hypoalphalipoproteinemia:

64
id Symbol AA change Variation ID SNP ID
1ABCA1p.Arg230CysVAR_012619rs9282541
2ABCA1p.Met1091ThrVAR_012628
3ABCA1p.Pro2150LeuVAR_012636
4ABCA1p.Pro85LeuVAR_017529rs145183203
5ABCA1p.Asp1099TyrVAR_017530rs28933692
6ABCA1p.Phe2009SerVAR_037971

Clinvar genetic disease variations for Hypoalphalipoproteinemia:

6
id Gene Name Type Significance SNP ID Assembly Location
1APOA1APOA1, 1-BP INSinsertionPathogenic
2APOA1APOA1, IVS2, G-C, +1single nucleotide variantPathogenic
3ABCA1NM_005502.3(ABCA1): c.3295G> T (p.Asp1099Tyr)single nucleotide variantPathogenicrs28933692GRCh37Chr 9, 107581111: 107581111
4ABCA1NM_005502.3(ABCA1): c.6026T> C (p.Phe2009Ser)single nucleotide variantPathogenicrs137854499GRCh37Chr 9, 107550750: 107550750
5ABCA1NM_005502.3(ABCA1): c.3847_3850delCGCC (p.Pro1284Serfs)deletionPathogenicrs387906415GRCh37Chr 9, 107576450: 107576453

Expression for genes affiliated with Hypoalphalipoproteinemia

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Expression patterns in normal tissues for genes affiliated with Hypoalphalipoproteinemia

Search GEO for disease gene expression data for Hypoalphalipoproteinemia.

Pathways for genes affiliated with Hypoalphalipoproteinemia

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Pathways related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCA1, APOA1, APOA2
2
Show member pathways
9.7ABCA1, APOA1, APOB
39.7LDLR, ABCA1, PPARA
4
Show member pathways
9.6LPL, LDLR, PPARA
5
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)37
Fatty Acid Beta Oxidation37
9.5SLC25A20, LPL, LIPC
69.1ABCA1, APOA1, APOA2, APOB, LPA
7
Show member pathways
thioredoxin pathway37
9.0ABCA1, APOA1, APOB, LDLR, GGT1
8
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.0PPARA, APOA1, APOC3, APOA2, LPL, PLTP
98.9APOA1, APOC3, APOA2, APOB, LDLR, LPL
10
Show member pathways
8.9APOA1, APOC3, APOA2, APOB, LDLR, LPL
11
Show member pathways
8.4PPARA, ABCA1, APOA1, APOA2, LPL, RORA
12
Show member pathways
7.7ABCA1, LCAT, PLTP, APOA1, APOC3, APOA2
13
Show member pathways
7.3ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
14
Show member pathways
5.1CETP, LPA, LPL, PLTP, LCAT, RORA

Compounds for genes affiliated with Hypoalphalipoproteinemia

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Compounds related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1psyllium449.6LCAT, APOB, LDLR, CETP
2fenofibric acid44 2810.4PPARA, APOA1, LPL, APOB, APOC3
3dimyristoylphosphatidylcholine449.4APOA2, LDLR, LPA, LCAT, APOA1
4ciprofibrate44 2810.3LDLR, PPARA, LPL, APOA1, APOB
5xbai449.3APOC3, APOB, LDLR, CETP, LPL
6ezetimibe44 1110.3APOA1, PPARA, ABCA1, CETP, LDLR, APOB
7cholestyramine449.3LDLR, CETP, APOC3, LPA, APOB
8rosuvastatin44 50 28 1112.2APOA1, PPARA, LDLR, CETP, APOB, APOC3
9hind iii449.2LIPC, LPA, LPL, ABCA1, APOC3
10dextran sulfate449.1APOA1, APOB, LDLR, CETP, LPL, PLTP
11sele449.1CETP, ACE, APOC3, LPL, LDLR
12stearic acid44 24 1111.0LIPC, LPL, CETP, LDLR, ABCA1, PPARA
13mspi449.0LPA, CETP, LDLR, APOB, APOA2, APOC3
14linoleic acid28 44 2410.9ABCA1, CETP, LDLR, LPL, LCAT, PPARA
15taurocholate448.9APOA1, APOC3, LPL, GBA, APOB
16palmitate448.9APOB, PPARA, LCAT, LPL, LDLR, CETP
17intralipid448.9APOA1, LCAT, LPL, CETP, LIPC, APOB
18carnitine448.8SLC25A20, PPARA, ABCA1, APOA1, APOB, LPL
19sterol448.8APOA1, CETP, LDLR, LIPC, APOB, ABCA1
20pioglitazone28 44 50 1111.6ABCA1, LPL, GGT1, LIPC, APOB, PPARA
21rosiglitazone28 44 50 24 1112.6PPARA, ABCA1, LPA, APOC3, APOB, LPL
22niacin44 119.6LPL, LPA, CETP, APOB, APOA1, ABCA1
23fluvastatin44 50 28 1111.6LDLR, APOA1, CETP, LPL, PPARA, ACE
24metformin44 50 1110.4APOB, GGT1, ACE, PPARA, LPL, APOA1
25probucol44 119.3LCAT, PLTP, LPL, CETP, LDLR, LIPC
26oleic acid44 28 24 1111.2LPA, CETP, LDLR, LIPC, APOB, ABCA1
27thyroxine44 249.2APOA1, APOB, LDLR, LIPC, CETP, LPA
28simvastatin44 50 61 28 24 1113.1LPA, CETP, LDLR, APOB, APOA1, ABCA1
29gemfibrozil28 44 1110.1LPA, LPL, CETP, LIPC, APOB, APOA2
30lovastatin44 50 61 28 1112.1APOA1, APOC3, APOB, GGT1, LPL, LPA
31triacylglycerol448.1LDLR, LIPC, APOB, APOA2, APOC3, APOA1
32alpha tocopherol448.0PPARA, ABCA1, GGT1, LCAT, PLTP, LPL
33phosphatidylcholine447.9ABCA1, APOA1, APOA2, APOB, LIPC, LDLR
34aspirin44 50 28 2410.8LPA, ACE, APOB, APOA1, ABCA1, CETP
35heparin44 28 24 1110.8LCAT, LPL, LPA, CETP, LDLR, APOB
36testosterone44 61 24 1110.7LIPC, APOA1, APOB, APOC3, ABCA1, PPARA
37phospholipid447.7APOB, CETP, LDLR, LIPC, APOA2, APOC3
38fenofibrate44 50 119.6PLTP, LPL, PPARA, ABCA1, LPA, CETP
39pravastatin44 50 28 24 1111.5LCAT, ACE, LPL, LPA, CETP, LDLR
40vitamin a44 24 119.5GGT1, LCAT, LPL, LPA, CETP, LIPC
41cholesterol ester447.4LCAT, PLTP, PPARA, ABCA1, APOA1, LPL
42estrogen447.3LCAT, PPARA, APOA1, LPL, APOC3, APOA2
43atorvastatin44 50 28 24 1111.2CETP, LDLR, LIPC, APOB, APOC3, APOA1
44fatty acid447.2PPARA, ABCA1, LPL, LPA, CETP, LDLR
45bezafibrate44 28 119.1ABCA1, PPARA, APOA1, APOC3, APOA2, GGT1
46creatinine447.1APOB, ACE, GGT1, PPARA, APOA1, APOC3
47serine446.8PPARA, ABCA1, APOC3, APOA2, APOB, LIPC
48glucose445.6PLTP, LPL, LPA, LIPC, RORA, GGT1
49cholesterol44 28 24 118.3LPA, LPL, ACE, PLTP, LCAT, RORA
50lipid444.9GBA, PPARA, GGT1, SLC25A20, RORA, LCAT

GO Terms for genes affiliated with Hypoalphalipoproteinemia

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Cellular components related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.9APOB, APOC3
2spherical high-density lipoprotein particleGO:0343669.8APOA1, APOC3, APOA2
3chylomicronGO:0426279.5APOC3, APOA2, APOB, LPL
4high-density lipoprotein particleGO:0343649.5APOA1, APOA2, LIPC, CETP, LCAT
5very-low-density lipoprotein particleGO:0343619.4LPL, APOB, APOA2, APOC3, APOA1
6early endosomeGO:0057699.1APOA1, APOC3, APOA2, APOB, LDLR
7extracellular spaceGO:0056157.7APOA1, APOC3, APOB, LIPC, CETP, LPL
8extracellular regionGO:0055767.5APOA1, APOC3, APOA2, APOB, CETP, LPA

Biological processes related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipase activityGO:06019210.4APOA1, APOA2
2regulation of intestinal cholesterol absorptionGO:03030010.4APOA1, APOA2
3negative regulation of cholesterol importGO:06062110.4APOA2, APOC3
4cholesterol importGO:07050810.4APOA1, LDLR
5protein oxidationGO:01815810.3APOA1, APOA2
6negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, APOA2
7high-density lipoprotein particle clearanceGO:03438410.3APOA1, APOA2
8high-density lipoprotein particle assemblyGO:03438010.3ABCA1, APOA1, APOA2
9regulation of Cdc42 protein signal transductionGO:03248910.2APOC3, APOA1, ABCA1
10negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.2APOA1, APOC3, APOA2
11peptidyl-methionine modificationGO:01820610.2APOA1, APOA2
12phospholipid homeostasisGO:05509110.2CETP, APOA1, ABCA1
13phosphatidylcholine biosynthetic processGO:00665610.2LCAT, APOA2, APOA1
14lipoprotein catabolic processGO:04215910.2APOB, LDLR
15triglyceride mobilizationGO:00664210.2APOC3, APOB
16chylomicron remnant clearanceGO:03438210.1APOC3, LIPC
17lipoprotein biosynthetic processGO:04215810.1APOA1, APOB, LCAT
18negative regulation of macrophage derived foam cell differentiationGO:01074510.1PPARA, ABCA1, CETP
19positive regulation of cholesterol esterificationGO:01087310.1APOA1, APOA2
20negative regulation of cholesterol storageGO:01088710.1PPARA, ABCA1
21phospholipid effluxGO:03370010.0APOA2, APOC3, APOA1, ABCA1
22response to estrogenGO:0436279.9GBA, APOA1, APOA2
23positive regulation of cholesterol storageGO:0108869.9APOB, LPL
24triglyceride metabolic processGO:0066419.9APOC3, APOA2, CETP, LPL
25low-density lipoprotein particle clearanceGO:0343839.9LDLR, APOB
26very-low-density lipoprotein particle remodelingGO:0343729.8LIPC, CETP, LPL, LCAT
27lipid transportGO:0068699.8PLTP, LPA, CETP
28low-density lipoprotein particle remodelingGO:0343749.8APOA2, APOB, LIPC, CETP
29response to nutrientGO:0075849.8APOC3, APOA1, ABCA1
30triglyceride catabolic processGO:0194339.7LPL, LIPC, APOB, APOC3
31cholesterol effluxGO:0333449.7ABCA1, APOA1, APOC3, APOA2, APOB
32response to drugGO:0424939.7ABCA1, APOA1, APOC3, APOA2, LPL
33cholesterol transportGO:0303019.6APOA1, APOB, LDLR, CETP, LCAT
34very-low-density lipoprotein particle assemblyGO:0343799.6APOB, APOC3
35negative regulation of inflammatory responseGO:0507289.6GBA, APOA1, RORA
36cellular lipid metabolic processGO:0442559.6PPARA, ABCA1, APOA1, APOA2, SLC25A20
37receptor-mediated endocytosisGO:0068989.5APOB, LDLR, CETP, LPA
38high-density lipoprotein particle remodelingGO:0343759.5APOA1, APOC3, APOA2, LIPC, CETP, LCAT
39lipid metabolic processGO:0066299.5PPARA, LDLR, LPA, PLTP
40retinoid metabolic processGO:0015239.4APOA1, APOC3, APOA2, APOB, LDLR, LPL
41phototransduction, visible lightGO:0076039.4APOA1, APOC3, APOA2, APOB, LDLR, LPL
42reverse cholesterol transportGO:0436919.3ABCA1, APOA1, APOC3, APOA2, LIPC, CETP
43triglyceride homeostasisGO:0703289.1APOA1, APOC3, LIPC, CETP, LPL, RORA
44cholesterol homeostasisGO:0426328.7APOC3, APOA2, APOB, LIPC, LDLR, CETP
45cholesterol metabolic processGO:0082038.7ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
46lipoprotein metabolic processGO:0421577.9LCAT, PPARA, ABCA1, APOA1, APOC3, APOA2
47small molecule metabolic processGO:0442816.6ABCA1, APOA1, APOC3, APOA2, APOB, LDLR

Molecular functions related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:03419010.2APOA1, APOA2
2apolipoprotein A-I bindingGO:03418610.1ABCA1, LCAT
3triglyceride bindingGO:01712910.1LPL, CETP
4high-density lipoprotein particle receptor bindingGO:07065310.1APOA2, APOC3, APOA1
5lipase inhibitor activityGO:05510210.1APOA1, APOC3, APOA2
6high-density lipoprotein particle bindingGO:00803510.1APOA2, APOA1
7phospholipid transporter activityGO:00554810.1ABCA1, APOA1, CETP
8phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.0APOA1, APOA2
9cholesterol bindingGO:0154859.7ABCA1, APOA1, APOC3, APOA2, CETP
10lipid bindingGO:0082899.6PPARA, APOA2, CETP, PLTP
11phospholipase activityGO:0046209.6LPL, LIPC
12cholesterol transporter activityGO:0171279.6CETP, APOB, APOA2, APOA1, ABCA1
13phospholipid bindingGO:0055439.6ABCA1, APOA1, APOC3, APOA2, APOB
14apolipoprotein bindingGO:0341859.5LPL, LPA, LIPC, ABCA1
15heparin bindingGO:0082019.2APOB, LIPC, LPA, LPL
16protein bindingGO:0055156.4GBA, PPARA, ABCA1, APOA1, APOA2, APOB

Products for genes affiliated with Hypoalphalipoproteinemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hypoalphalipoproteinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet