MCID: HYP121
MIFTS: 52

Hypoalphalipoproteinemia malady

Genetic diseases (common) category

Summaries for Hypoalphalipoproteinemia

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant... more...

MalaCards: Hypoalphalipoproteinemia, also known as hypoalphalipoproteinemias, is related to fish-eye disease and tangier disease. An important gene associated with Hypoalphalipoproteinemia is APOA1 (apolipoprotein A-I), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Fat digestion and absorption. The compounds psyllium and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and kidney, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Description from OMIM:48 604091

Aliases & Classifications for Hypoalphalipoproteinemia

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48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

hypoalphalipoproteinemia 48 46
hypoalphalipoproteinemias 63


Related Diseases for Hypoalphalipoproteinemia

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18GeneCards, 19GeneDecks
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Diseases related to Hypoalphalipoproteinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease30.3LCAT, APOA2, APOA1
2tangier disease30.3APOA1, ABCA1, PPARA, APOC3, APOA2, LCAT
3hepatic lipase deficiency30.1LIPC
4hypertriglyceridemia30.1GGT1, LCAT, PLTP, LPL, LPA, CETP
5familial hypercholesterolemia30.1CETP, APOB, LDLR
6amyloidosis30.0APOA1, APOA2, LPA, LPL
7hypercholesterolemia29.9PPARA, GGT1, LCAT, ACE, LPL, LPA
8coronary artery disease29.8LCAT, PLTP, ACE, LPL, LPA, CETP
9hypertension29.8PPARA, APOA1, ACE, GGT1, APOB, LPA
10atherosclerosis29.6LPL, CETP, LCAT, PLTP, ACE, LPA
11obesity29.6LPL, LPA, CETP, LDLR, LIPC, APOB
12familial hdl deficiency10.4
13artery disease10.2
14eye disease10.1
15hepatitis10.1
16cerebral atherosclerosis10.1APOA1
17chylomicron retention disease10.1APOB
18gallbladder disease10.1GGT1
19amyloidosis, renal10.1APOA2, APOA1
20lipase deficiency combined10.1LPL, LIPC
21familial combined hyperlipidemia10.1APOB, APOA1
22arcus senilis10.1APOA1, APOB, LCAT
23familial hypertriglyceridemia10.1APOC3, APOB, LPL
24splenomegaly10.0GBA, ABCA1, LCAT
25amyloidosis, secondary10.0LPA, APOA1, LCAT
26hypobetalipoproteinemia10.0LCAT, APOA1, APOB, LDLR
27protein s deficiency10.0SLC25A20, PLTP, CETP
28alagille syndrome10.0APOA1, LPA, LCAT
29xanthomatosis10.0ABCA1, LDLR, LPL, APOB
30polycystic ovary syndrome10.0APOA1, LIPC, PPARA
31glucose intolerance10.0LPL, APOB, PPARA
32complete lcat deficiency10.0APOA1, LCAT, LPA, APOA2
33arteriosclerosis10.0APOB, LDLR, APOA1, LPL
34hypothyroidism10.0APOB, CETP, LPA
35norum disease10.0APOA2, APOA1, LCAT, LPL, APOB
36idiopathic edema10.0ACE, PPARA
37abetalipoproteinemia10.0LCAT, CETP, APOB, APOA1, LPL
38hepatoblastoma10.0APOA1, LDLR, PPARA, APOA2, APOB
39hypertension, diastolic10.0ACE, GGT1
40hypertensive heart disease10.0ACE, PPARA
41galactosemia10.0SLC25A20, LDLR, GGT1
42cholestasis10.0GGT1, CETP, LIPC, LCAT
43lipodystrophy10.0PPARA, APOB, LDLR, LPL, APOC3
44obstructive jaundice10.0LCAT, GGT1
45coronary stenosis10.0APOA1, CETP, LPA, LIPC, APOB
46hepatitis c10.0LDLR, GGT1, LIPC
47dementia10.0LPA, GBA, LPL, CETP
48stroke, ischemic10.0LPA, APOA1, ACE, APOB
49hyperhomocysteinemia10.0
50sarcoidosis10.0

Graphical network of the top 20 diseases related to Hypoalphalipoproteinemia:



Diseases related to hypoalphalipoproteinemia

Symptoms for Hypoalphalipoproteinemia

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48OMIM
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Clinical features from OMIM:

604091

Drugs & Therapeutics for Hypoalphalipoproteinemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hypoalphalipoproteinemia

Drug clinical trials:

Search ClinicalTrials for Hypoalphalipoproteinemia

Search NIH Clinical Center for Hypoalphalipoproteinemia

Search CenterWatch for Hypoalphalipoproteinemia

Genetic Tests for Hypoalphalipoproteinemia

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Anatomical Context for Hypoalphalipoproteinemia

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34MalaCards
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MalaCards organs/tissues related to Hypoalphalipoproteinemia:

34
Eye, Heart, Kidney, Monocytes, Endothelial

Animal Models for Hypoalphalipoproteinemia or affiliated genes

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38MGI
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Publications for Hypoalphalipoproteinemia

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53PubMed
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Articles related to Hypoalphalipoproteinemia:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Prevalence of classical CD14++/CD16- but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia. (23623664)
2013
2
Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity. (24322908)
2013
3
An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. (21575609)
2011
4
Acquired severe hypercholesterolemia and hypoalphalipoproteinemia. (21291840)
2009
5
Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment. (19280764)
2009
6
Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. (19616211)
2009
7
Genetically based hypertension generated through interaction of mild hypoalphalipoproteinemia and mild hyperhomocysteinemia. (17620955)
2007
8
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. (16957769)
2007
9
Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. (16388083)
2006
10
Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. (16225879)
2006
11
Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. (16127020)
2005
12
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. (15841208)
2005
13
C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. (15562377)
2005
14
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. (12700344)
2003
15
Increased plasma C-reactive protein in familial hypoalphalipoproteinemia: a proinflammatory condition? (11772869)
2002
16
Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia. (12048121)
2002
17
ApoA-I(MALLORCA) impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia. (11792730)
2002
18
Corticosteroid therapy increases HDL-cholesterol concentrations in patients with active sarcoidosis and hypoalphalipoproteinemia. (11983201)
2002
19
Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia. (11834535)
2002
20
Lecithin:cholesterol acyl transferase G30S: association with atherosclerosis, hypoalphalipoproteinemia and reduced in vivo enzyme activity. (11522275)
2001
21
Improvement in endothelial dysfunction in patients with hypoalphalipoproteinemia and coronary artery disease treated with bezafibrate. (11483875)
2001
22
Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations. (10998475)
2000
23
Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. (10775531)
2000
24
Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease. (10551691)
1999
25
Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. (10064737)
1999
26
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. (9851961)
1998
27
Genetic polymorphisms and mutations of the lipoprotein lipase gene in Japanese schoolchildren with hypoalphalipoproteinemia. (9730139)
1998
28
Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease. (8883496)
1996
29
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia. (7712672)
1995
30
Increase of gamma-glutamyltranspeptidase in patients with compensated hypoalphalipoproteinemia and type IIa dyslipidemias]. (7627821)
1995
31
Lipoprotein responses to treatment with lovastatin, gemfibrozil, and nicotinic acid in normolipidemic patients with hypoalphalipoproteinemia. (8267492)
1994
32
Familial hypoalphalipoproteinemia in premature coronary artery disease. (8241092)
1993
33
Low levels of high-density lipoprotein cholesterol (hypoalphalipoproteinemia). An approach to management. (8323418)
1993
34
A case report: familial hypoalphalipoproteinemia. (8348223)
1993
35
Hypoalphalipoproteinemia: postprandial response of subjects with preprandial normotriglyceridemia and hypertriglyceridemia to various diets. (8474323)
1993
36
Hypoalphalipoproteinemia. (1458423)
1992
37
Analysis of familial hypoalphalipoproteinemia syndromes. (1518505)
1992
38
In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. (1619367)
1992
39
Apolipoprotein A-I metabolism in subjects with a PstI restriction fragment length polymorphism of the apoA-I gene and familial hypoalphalipoproteinemia. (1981893)
1990
40
Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. (2810673)
1989
41
Erythrocyte abnormalities in a hypoalphalipoproteinemia syndrome resembling fish eye disease. (3410011)
1988
42
Hypoalphalipoproteinemia resembling fish eye disease. (3591467)
1987
43
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. (3081805)
1986
44
Restriction-fragment-length polymorphisms in the A-I-C-III gene complex occurring in a family with hypoalphalipoproteinemia. (2877676)
1986
45
Familial hypoalphalipoproteinemia. (3541525)
1986
46
A major gene for primary hypoalphalipoproteinemia. (3953576)
1986
47
A family study of hypoalphalipoproteinemia. (3541526)
1986
48
A genetic study of hypoalphalipoproteinemia. (6544231)
1984
49
Primary and familial hypoalphalipoproteinemia. (6694557)
1984
50
Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism. (7231186)
1981

Variations for Hypoalphalipoproteinemia

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Hypoalphalipoproteinemia:

65
id Symbol AA change Variation ID SNP ID
1ABCA1p.Arg230CysVAR_012619rs9282541
2ABCA1p.Met1091ThrVAR_012628
3ABCA1p.Pro2150LeuVAR_012636
4ABCA1p.Pro85LeuVAR_017529rs145183203
5ABCA1p.Asp1099TyrVAR_017530rs28933692
6ABCA1p.Phe2009SerVAR_037971

Clinvar genetic disease variations for Hypoalphalipoproteinemia:

1
id Gene Name Type Significance SNP ID Assembly Location
1APOA1APOA1, 1-BP INSinsertionPathogenic
2APOA1APOA1, IVS2, G-C, +1single nucleotide variantPathogenic
3ABCA1NM_005502.3(ABCA1): c.3295G> T (p.Asp1099Tyr)single nucleotide variantPathogenicrs28933692GRCh37Chr 9, 107581111: 107581111
4ABCA1NM_005502.3(ABCA1): c.6026T> C (p.Phe2009Ser)single nucleotide variantPathogenicrs137854499GRCh37Chr 9, 107550750: 107550750
5ABCA1NM_005502.3(ABCA1): c.3847_3850delCGCC (p.Pro1284Serfs)deletionPathogenicrs387906415GRCh37Chr 9, 107576450: 107576453

Expression for genes affiliated with Hypoalphalipoproteinemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoalphalipoproteinemia

Search GEO for disease gene expression data for Hypoalphalipoproteinemia.

Pathways for genes affiliated with Hypoalphalipoproteinemia

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51PathCards, 61Thomson Reuters, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 52PharmGKB
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Pathways related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCA1, APOA1, APOA2
2
Show member pathways
9.7ABCA1, APOA1, APOB
39.7LDLR, ABCA1, PPARA
4
Show member pathways
9.6LPL, LDLR, PPARA
5
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)39
Fatty Acid Beta Oxidation39
9.5SLC25A20, LPL, LIPC
69.1ABCA1, APOA1, APOA2, APOB, LPA
7
Show member pathways
thioredoxin pathway39
9.0ABCA1, APOA1, APOB, LDLR, GGT1
8
Show member pathways
fatty acid beta-oxidation VI (peroxisome)39
9.0PPARA, APOA1, APOC3, APOA2, LPL, PLTP
98.9APOA1, APOC3, APOA2, APOB, LDLR, LPL
10
Show member pathways
8.9APOA1, APOC3, APOA2, APOB, LDLR, LPL
11
Show member pathways
8.4PPARA, ABCA1, APOA1, APOA2, LPL, RORA
12
Show member pathways
7.7ABCA1, LCAT, PLTP, APOA1, APOC3, APOA2
13
Show member pathways
7.3ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
14
Show member pathways
5.1CETP, LPA, LPL, PLTP, LCAT, RORA

Compounds for genes affiliated with Hypoalphalipoproteinemia

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1psyllium469.6LCAT, APOB, LDLR, CETP
2fenofibric acid46 3010.4PPARA, APOA1, LPL, APOB, APOC3
3dimyristoylphosphatidylcholine469.4APOA2, LDLR, LPA, LCAT, APOA1
4ciprofibrate46 3010.3LDLR, PPARA, LPL, APOA1, APOB
5xbai469.3APOC3, APOB, LDLR, CETP, LPL
6ezetimibe46 1210.3APOA1, PPARA, ABCA1, CETP, LDLR, APOB
7cholestyramine469.3LDLR, CETP, APOC3, LPA, APOB
8rosuvastatin46 52 30 1212.2APOA1, PPARA, LDLR, CETP, APOB, APOC3
9hind iii469.2LIPC, LPA, LPL, ABCA1, APOC3
10dextran sulfate469.1APOA1, APOB, LDLR, CETP, LPL, PLTP
11sele469.1CETP, ACE, APOC3, LPL, LDLR
12stearic acid46 25 1211.0LIPC, LPL, CETP, LDLR, ABCA1, PPARA
13mspi469.0LPA, CETP, LDLR, APOB, APOA2, APOC3
14linoleic acid30 46 2510.9ABCA1, CETP, LDLR, LPL, LCAT, PPARA
15taurocholate468.9APOA1, APOC3, LPL, GBA, APOB
16palmitate468.9APOB, PPARA, LCAT, LPL, LDLR, CETP
17intralipid468.9APOA1, LCAT, LPL, CETP, LIPC, APOB
18carnitine468.8SLC25A20, PPARA, ABCA1, APOA1, APOB, LPL
19sterol468.8APOA1, CETP, LDLR, LIPC, APOB, ABCA1
20pioglitazone30 46 52 1211.6ABCA1, LPL, GGT1, LIPC, APOB, PPARA
21rosiglitazone30 46 52 25 1212.6PPARA, ABCA1, LPA, APOC3, APOB, LPL
22niacin46 129.6LPL, LPA, CETP, APOB, APOA1, ABCA1
23fluvastatin46 52 30 1211.6LDLR, APOA1, CETP, LPL, PPARA, ACE
24metformin46 52 1210.4APOB, GGT1, ACE, PPARA, LPL, APOA1
25probucol46 129.3LCAT, PLTP, LPL, CETP, LDLR, LIPC
26oleic acid46 30 25 1211.2LPA, CETP, LDLR, LIPC, APOB, ABCA1
27thyroxine46 259.2APOA1, APOB, LDLR, LIPC, CETP, LPA
28simvastatin46 52 62 30 25 1213.1LPA, CETP, LDLR, APOB, APOA1, ABCA1
29gemfibrozil30 46 1210.1LPA, LPL, CETP, LIPC, APOB, APOA2
30lovastatin46 52 62 30 1212.1APOA1, APOC3, APOB, GGT1, LPL, LPA
31triacylglycerol468.1LDLR, LIPC, APOB, APOA2, APOC3, APOA1
32alpha tocopherol468.0PPARA, ABCA1, GGT1, LCAT, PLTP, LPL
33phosphatidylcholine467.9ABCA1, APOA1, APOA2, APOB, LIPC, LDLR
34aspirin46 52 30 2510.8LPA, ACE, APOB, APOA1, ABCA1, CETP
35heparin46 30 25 1210.8LCAT, LPL, LPA, CETP, LDLR, APOB
36testosterone46 62 25 1210.7LIPC, APOA1, APOB, APOC3, ABCA1, PPARA
37phospholipid467.7APOB, CETP, LDLR, LIPC, APOA2, APOC3
38fenofibrate46 52 129.6PLTP, LPL, PPARA, ABCA1, LPA, CETP
39pravastatin46 52 30 25 1211.5LCAT, ACE, LPL, LPA, CETP, LDLR
40vitamin a46 25 129.5GGT1, LCAT, LPL, LPA, CETP, LIPC
41cholesterol ester467.4LCAT, PLTP, PPARA, ABCA1, APOA1, LPL
42estrogen467.3LCAT, PPARA, APOA1, LPL, APOC3, APOA2
43atorvastatin46 52 30 25 1211.2CETP, LDLR, LIPC, APOB, APOC3, APOA1
44fatty acid467.2PPARA, ABCA1, LPL, LPA, CETP, LDLR
45bezafibrate46 30 129.1ABCA1, PPARA, APOA1, APOC3, APOA2, GGT1
46creatinine467.1APOB, ACE, GGT1, PPARA, APOA1, APOC3
47serine466.8PPARA, ABCA1, APOC3, APOA2, APOB, LIPC
48glucose465.6PLTP, LPL, LPA, LIPC, RORA, GGT1
49cholesterol46 30 25 128.3LPA, LPL, ACE, PLTP, LCAT, RORA
50lipid464.9GBA, PPARA, GGT1, SLC25A20, RORA, LCAT

GO Terms for genes affiliated with Hypoalphalipoproteinemia

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17Gene Ontology
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Cellular components related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.9APOB, APOC3
2spherical high-density lipoprotein particleGO:0343669.8APOA1, APOC3, APOA2
3chylomicronGO:0426279.5APOC3, APOA2, APOB, LPL
4high-density lipoprotein particleGO:0343649.5APOA1, APOA2, LIPC, CETP, LCAT
5very-low-density lipoprotein particleGO:0343619.4LPL, APOB, APOA2, APOC3, APOA1
6early endosomeGO:0057699.1APOA1, APOC3, APOA2, APOB, LDLR
7extracellular spaceGO:0056157.7APOA1, APOC3, APOB, LIPC, CETP, LPL
8extracellular regionGO:0055767.5APOA1, APOC3, APOA2, APOB, CETP, LPA

Biological processes related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipase activityGO:06019210.4APOA2, APOA1
2regulation of intestinal cholesterol absorptionGO:03030010.4APOA2, APOA1
3negative regulation of cholesterol importGO:06062110.4APOA2, APOC3
4cholesterol importGO:07050810.4LDLR, APOA1
5negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, APOA2
6protein oxidationGO:01815810.3APOA1, APOA2
7high-density lipoprotein particle clearanceGO:03438410.3APOA2, APOA1
8high-density lipoprotein particle assemblyGO:03438010.3APOA1, ABCA1, APOA2
9regulation of Cdc42 protein signal transductionGO:03248910.2APOC3, APOA1, ABCA1
10negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.2APOA1, APOC3, APOA2
11peptidyl-methionine modificationGO:01820610.2APOA2, APOA1
12phospholipid homeostasisGO:05509110.2CETP, APOA1, ABCA1
13phosphatidylcholine biosynthetic processGO:00665610.2LCAT, APOA2, APOA1
14lipoprotein catabolic processGO:04215910.2LDLR, APOB
15triglyceride mobilizationGO:00664210.2APOC3, APOB
16chylomicron remnant clearanceGO:03438210.1LIPC, APOC3
17positive regulation of cholesterol esterificationGO:01087310.1APOA1, APOA2
18lipoprotein biosynthetic processGO:04215810.1APOA1, APOB, LCAT
19negative regulation of macrophage derived foam cell differentiationGO:01074510.1ABCA1, PPARA, CETP
20negative regulation of cholesterol storageGO:01088710.1PPARA, ABCA1
21phospholipid effluxGO:03370010.0APOA2, APOC3, APOA1, ABCA1
22response to estrogenGO:0436279.9APOA2, APOA1, GBA
23triglyceride metabolic processGO:0066419.9APOC3, APOA2, CETP, LPL
24low-density lipoprotein particle clearanceGO:0343839.9LDLR, APOB
25very-low-density lipoprotein particle remodelingGO:0343729.8LIPC, CETP, LPL, LCAT
26positive regulation of cholesterol storageGO:0108869.8LPL, APOB
27lipid transportGO:0068699.8LPA, PLTP, CETP
28low-density lipoprotein particle remodelingGO:0343749.8APOB, LIPC, CETP, APOA2
29response to nutrientGO:0075849.8APOC3, APOA1, ABCA1
30triglyceride catabolic processGO:0194339.7LPL, APOB, LIPC, APOC3
31cholesterol effluxGO:0333449.7APOA1, APOC3, APOA2, APOB, ABCA1
32response to drugGO:0424939.7APOC3, APOA1, ABCA1, APOA2, LPL
33cholesterol transportGO:0303019.6APOA1, APOB, CETP, LCAT, LDLR
34very-low-density lipoprotein particle assemblyGO:0343799.6APOC3, APOB
35negative regulation of inflammatory responseGO:0507289.6RORA, GBA, APOA1
36cellular lipid metabolic processGO:0442559.6SLC25A20, APOA2, APOA1, ABCA1, PPARA
37receptor-mediated endocytosisGO:0068989.5LDLR, LPA, CETP, APOB
38high-density lipoprotein particle remodelingGO:0343759.5CETP, LIPC, APOA2, APOC3, APOA1, LCAT
39lipid metabolic processGO:0066299.5PPARA, PLTP, LPA, LDLR
40retinoid metabolic processGO:0015239.4LPL, APOA1, APOC3, APOB, APOA2, LDLR
41phototransduction, visible lightGO:0076039.4APOA1, LPL, APOB, LDLR, APOC3, APOA2
42reverse cholesterol transportGO:0436919.3APOA2, LIPC, APOA1, ABCA1, CETP, LCAT
43triglyceride homeostasisGO:0703289.1CETP, APOA1, APOC3, LIPC, LPL, RORA
44cholesterol metabolic processGO:0082038.7ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
45cholesterol homeostasisGO:0426328.7APOA2, APOB, ABCA1, APOA1, APOC3, LIPC
46lipoprotein metabolic processGO:0421577.9APOA2, LCAT, ABCA1, PPARA, LPL, LDLR
47small molecule metabolic processGO:0442816.6LCAT, LPL, LPA, CETP, GGT1, SLC25A20

Molecular functions related to Hypoalphalipoproteinemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I bindingGO:03418610.2ABCA1, LCAT
2apolipoprotein receptor bindingGO:03419010.1APOA2, APOA1
3triglyceride bindingGO:01712910.1LPL, CETP
4high-density lipoprotein particle receptor bindingGO:07065310.1APOC3, APOA2, APOA1
5lipase inhibitor activityGO:05510210.1APOA2, APOA1, APOC3
6high-density lipoprotein particle bindingGO:00803510.1APOA1, APOA2
7phospholipid transporter activityGO:00554810.1ABCA1, APOA1, CETP
8phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.0APOA1, APOA2
9cholesterol bindingGO:0154859.7ABCA1, APOA1, APOC3, APOA2, CETP
10lipid bindingGO:0082899.6PPARA, APOA2, CETP, PLTP
11phospholipase activityGO:0046209.6LPL, LIPC
12cholesterol transporter activityGO:0171279.6APOB, APOA2, APOA1, ABCA1, CETP
13phospholipid bindingGO:0055439.6ABCA1, APOB, APOA1, APOC3, APOA2
14apolipoprotein bindingGO:0341859.5ABCA1, LPA, LPL, LIPC
15heparin bindingGO:0082019.2LPL, LPA, LIPC, APOB
16protein bindingGO:0055156.4LDLR, ACE, RORA, GGT1, LCAT, LPL

Products for genes affiliated with Hypoalphalipoproteinemia

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  • Antibodies
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Sources for Hypoalphalipoproteinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet