MCID: HYP121
MIFTS: 64

Hypoalphalipoproteinemia malady

Genetic diseases, Rare diseases, Metabolic diseases, Endocrine diseases categories

Aliases & Classifications for Hypoalphalipoproteinemia

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Sources:
45OMIM, 10diseasecard, 41NIH Rare Diseases, 21Genetics Home Reference, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Hypoalphalipoproteinemia, Aliases & Descriptions:

Name: Hypoalphalipoproteinemia 45 43
Hdl Deficiency, Type 2 45 10 21 60
Familial Hypoalphalipoproteinemia 41 21 47
Apolipoprotein a-I Deficiency 41 47 60
Familial Hdl Deficiency 41 21 60
High Density Lipoprotein Deficiency 41 60
Hypoalphalipoproteinemia, Familial 41 60
Familial Apoa-I Deficiency 41 47
 
Apoa-I Deficiency 41 47
Hdld 41 21
Fha 41 21
Familial Hypoalphalipo-Proteinemia 22
Hypoalphalipoproteinemia, Primary 41
Primary Hypoalphalipoproteinemia 21
Low Serum Hdl Cholesterol 21
Fhd 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
familial hypoalphalipoproteinemia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age


External Ids:

OMIM45 604091
Orphanet47 425
MESH via Orphanet34 D052456
ICD10 via Orphanet26 E78.6
UMLS via Orphanet61 C0342898, C1704429

Summaries for Hypoalphalipoproteinemia

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Genetics Home Reference:21 Familial HDL deficiency is a condition characterized by low levels of high-density lipoprotein (HDL) in the blood. HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. HDL is often referred to as "good cholesterol" because high levels of this substance reduce the chances of developing heart and blood vessel (cardiovascular) disease. People with familial HDL deficiency may develop cardiovascular disease at a relatively young age, often before age 50.

MalaCards based summary: Hypoalphalipoproteinemia, also known as hdl deficiency, type 2, is related to hypertriglyceridemia and fish-eye disease, and has symptoms including multiple lipomas, coronary artery disease and cerebral ischemia. An important gene associated with Hypoalphalipoproteinemia is APOA1 (apolipoprotein A-I), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Fat digestion and absorption. The compounds psyllium and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and spleen, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

OMIM:45 Twenty to 30% of early familial coronary heart disease (CHD) is ascribed to hypoalphalipoproteinemia, or high density... (604091) more...

Wikipedia:63 Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant... more...

Related Diseases for Hypoalphalipoproteinemia

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Diseases related to Hypoalphalipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hypertriglyceridemia30.9APOC3, APOB, LPL
2fish-eye disease30.9LCAT, APOA2, APOA1
3hepatic lipase deficiency30.7LIPC
4norum disease30.5LCAT, APOA2, APOA1
5amyloidosis30.1APOA1, APOA2, LPA, LPL
6tangier disease29.6APOA1, ABCA1, PPARA, APOC3, APOA2, LCAT
7hyperalphalipoproteinemia29.4LIPC, APOB, APOA2, APOC3, APOA1, ABCA1
8coronary artery disease28.2LCAT, PLTP, ACE, LPL, LPA, CETP
9obesity28.2LPL, LPA, CETP, LDLR, LIPC, APOB
10atherosclerosis27.6LPL, CETP, LCAT, PLTP, ACE, LPA
11abca1-related familial high density lipoprotein deficiency10.5
12abca1-associated familial high density lipoprotein deficiency10.5
13apoa1-associated familial high density lipoprotein deficiency10.5
14cerebral atherosclerosis10.5APOA1
15chylomicron retention disease10.4APOB
16gallbladder disease10.4GGT1
17amyloidosis, familial visceral10.4APOA2, APOA1
18lipase deficiency, combined10.3LPL, LIPC
19hyperlipidemia, familial combined10.3APOB, APOA1
20hypercholesterolemia, due to ligand-defective apo b10.3LDLR, APOB
21arcus senilis10.3APOA1, APOB, LCAT
22hypercholesterolemia, familial10.3CETP, APOB, LDLR
23hodgkin lymphoma10.3
24artery disease10.2
25splenomegaly10.2GBA, ABCA1, LCAT
26secondary amyloidosis10.2LPA, APOA1, LCAT
27hypobetalipoproteinemia10.2LCAT, APOA1, APOB, LDLR
28alagille syndrome10.2APOA1, LPA, LCAT
29cerebral amyloid angiopathy10.2
30cerebritis10.2
31xanthomatosis10.2ABCA1, LDLR, LPL, APOB
32polycystic ovary syndrome10.2APOA1, LIPC, PPARA
33glucose intolerance10.2LPL, APOB, PPARA
34arteriosclerosis10.1APOB, LDLR, APOA1, LPL
35hepatitis10.1
36eye disease10.1
37hypothyroidism10.1APOB, CETP, LPA
38idiopathic edema10.1ACE, PPARA
39abetalipoproteinemia10.1LCAT, CETP, APOB, APOA1, LPL
40breast cancer10.1
41sporadic breast cancer10.1
42pertussis10.1
43hepatoblastoma10.1APOA1, LDLR, PPARA, APOA2, APOB
44hypertension, diastolic10.1ACE, GGT1
45hypertensive heart disease10.0ACE, PPARA
46galactosemia10.0SLC25A20, LDLR, GGT1
47cholestasis10.0GGT1, CETP, LIPC, LCAT
48lipodystrophy10.0PPARA, APOB, LDLR, LPL, APOC3
49alstrom syndrome10.0
50lipodystrophy, familial partial, type 310.0

Graphical network of the top 20 diseases related to Hypoalphalipoproteinemia:



Diseases related to hypoalphalipoproteinemia

Symptoms for Hypoalphalipoproteinemia

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Clinical features from OMIM:

604091

Symptoms:

 47 (show all 10)
  • hepatitis/icterus/cholestasis
  • storage liver disease
  • splenomegaly
  • lymphadenopathy/polyadenopathies
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • anaemia
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • autosomal recessive inheritance

HPO human phenotypes related to Hypoalphalipoproteinemia:

(show all 25)
id Description Frequency HPO Source Accession
1 multiple lipomas hallmark (90%) HP:0001012
2 coronary artery disease hallmark (90%) HP:0001677
3 cerebral ischemia hallmark (90%) HP:0002637
4 abnormality of lipid metabolism hallmark (90%) HP:0003119
5 opacification of the corneal stroma hallmark (90%) HP:0007759
6 abnormality of the liver typical (50%) HP:0001392
7 splenomegaly typical (50%) HP:0001744
8 anemia typical (50%) HP:0001903
9 lymphadenopathy typical (50%) HP:0002716
10 abnormality of lipid metabolism typical (50%) HP:0003119
11 emg abnormality typical (50%) HP:0003457
12 hemiplegia/hemiparesis typical (50%) HP:0004374
13 sudden cardiac death occasional (7.5%) HP:0001645
14 autosomal dominant inheritance HP:0000006
15 renal insufficiency HP:0000083
16 polyneuropathy HP:0001271
17 abnormality of the liver HP:0001392
18 abnormality of the integument HP:0001574
19 congestive heart failure HP:0001635
20 abnormality of the spleen HP:0001743
21 renal amyloidosis HP:0001917
22 peptic ulcer HP:0004398
23 coronary atherosclerosis HP:0004929
24 opacification of the corneal stroma HP:0007759
25 hypoalphalipoproteinemia HP:0003233

Drugs & Therapeutics for Hypoalphalipoproteinemia

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Drug clinical trials:

Search ClinicalTrials for Hypoalphalipoproteinemia

Search NIH Clinical Center for Hypoalphalipoproteinemia

Genetic Tests for Hypoalphalipoproteinemia

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Genetic tests related to Hypoalphalipoproteinemia:

id Genetic test Affiliating Genes
1 Familial Hypoalphalipoproteinemia22

Anatomical Context for Hypoalphalipoproteinemia

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MalaCards organs/tissues related to Hypoalphalipoproteinemia:

31
Liver, Heart, Spleen, Eye, Kidney, Monocytes, Endothelial

Animal Models for Hypoalphalipoproteinemia or affiliated genes

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Publications for Hypoalphalipoproteinemia

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Articles related to Hypoalphalipoproteinemia:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Prevalence of classical CD14++/CD16- but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia. (23623664)
2013
2
Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity. (24322908)
2013
3
An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. (21575609)
2011
4
Acquired severe hypercholesterolemia and hypoalphalipoproteinemia. (21291840)
2009
5
Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment. (19280764)
2009
6
Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. (19616211)
2009
7
Genetically based hypertension generated through interaction of mild hypoalphalipoproteinemia and mild hyperhomocysteinemia. (17620955)
2007
8
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. (16957769)
2007
9
Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. (16388083)
2006
10
Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. (16225879)
2006
11
Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. (16127020)
2005
12
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. (15841208)
2005
13
C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. (15562377)
2005
14
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. (12700344)
2003
15
Increased plasma C-reactive protein in familial hypoalphalipoproteinemia: a proinflammatory condition? (11772869)
2002
16
Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia. (12048121)
2002
17
ApoA-I(MALLORCA) impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia. (11792730)
2002
18
Corticosteroid therapy increases HDL-cholesterol concentrations in patients with active sarcoidosis and hypoalphalipoproteinemia. (11983201)
2002
19
Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia. (11834535)
2002
20
Lecithin:cholesterol acyl transferase G30S: association with atherosclerosis, hypoalphalipoproteinemia and reduced in vivo enzyme activity. (11522275)
2001
21
Improvement in endothelial dysfunction in patients with hypoalphalipoproteinemia and coronary artery disease treated with bezafibrate. (11483875)
2001
22
Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations. (10998475)
2000
23
Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. (10775531)
2000
24
Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease. (10551691)
1999
25
Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. (10064737)
1999
26
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. (9851961)
1998
27
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (9555865)
1998
28
Genetic polymorphisms and mutations of the lipoprotein lipase gene in Japanese schoolchildren with hypoalphalipoproteinemia. (9730139)
1998
29
Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease. (8883496)
1996
30
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia. (7712672)
1995
31
Increase of gamma-glutamyltranspeptidase in patients with compensated hypoalphalipoproteinemia and type IIa dyslipidemias]. (7627821)
1995
32
Familial hypoalphalipoproteinemia in premature coronary artery disease. (8241092)
1993
33
Low levels of high-density lipoprotein cholesterol (hypoalphalipoproteinemia). An approach to management. (8323418)
1993
34
A case report: familial hypoalphalipoproteinemia. (8348223)
1993
35
Hypoalphalipoproteinemia: postprandial response of subjects with preprandial normotriglyceridemia and hypertriglyceridemia to various diets. (8474323)
1993
36
Hypoalphalipoproteinemia. (1458423)
1992
37
Analysis of familial hypoalphalipoproteinemia syndromes. (1518505)
1992
38
In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. (1619367)
1992
39
The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family. (1969839)
1990
40
Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. (2810673)
1989
41
Erythrocyte abnormalities in a hypoalphalipoproteinemia syndrome resembling fish eye disease. (3410011)
1988
42
Hypoalphalipoproteinemia resembling fish eye disease. (3591467)
1987
43
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. (3081805)
1986
44
Restriction-fragment-length polymorphisms in the A-I-C-III gene complex occurring in a family with hypoalphalipoproteinemia. (2877676)
1986
45
Familial hypoalphalipoproteinemia. (3541525)
1986
46
A major gene for primary hypoalphalipoproteinemia. (3953576)
1986
47
A family study of hypoalphalipoproteinemia. (3541526)
1986
48
A genetic study of hypoalphalipoproteinemia. (6544231)
1984
49
Primary and familial hypoalphalipoproteinemia. (6694557)
1984
50
Hypertriglyceridemia and hypoalphalipoproteinemia in azoospermic and oligospermic young men: relationships of endogenous testosterone to triglyceride and high density lipoprotein cholesterol metabolism. (7231186)
1981

Variations for Hypoalphalipoproteinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hypoalphalipoproteinemia:

62
id Symbol AA change Variation ID SNP ID
1ABCA1p.Arg230CysVAR_012619rs9282541
2ABCA1p.Met1091ThrVAR_012628
3ABCA1p.Pro2150LeuVAR_012636
4ABCA1p.Pro85LeuVAR_017529rs145183203
5ABCA1p.Asp1099TyrVAR_017530rs28933692
6ABCA1p.Phe2009SerVAR_037971

Clinvar genetic disease variations for Hypoalphalipoproteinemia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1APOA1APOA1, 1-BP INSinsertionPathogenic
2APOA1APOA1, IVS2, G-C, +1single nucleotide variantPathogenic
3ABCA1NM_005502.3(ABCA1): c.3295G> T (p.Asp1099Tyr)single nucleotide variantPathogenicrs28933692GRCh37Chr 9, 107581111: 107581111
4ABCA1NM_005502.3(ABCA1): c.6026T> C (p.Phe2009Ser)single nucleotide variantPathogenicrs137854499GRCh37Chr 9, 107550750: 107550750
5ABCA1NM_005502.3(ABCA1): c.3847_3850delCGCC (p.Pro1284Serfs)deletionPathogenicrs387906415GRCh37Chr 9, 107576450: 107576453

Expression for genes affiliated with Hypoalphalipoproteinemia

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Search GEO for disease gene expression data for Hypoalphalipoproteinemia.

Pathways for genes affiliated with Hypoalphalipoproteinemia

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Pathways related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCA1, APOA2, APOA1
2
Show member pathways
9.7ABCA1, APOB, APOA1
39.7PPARA, LDLR, ABCA1
4
Show member pathways
9.6LPL, PPARA, LDLR
5
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)36
Fatty Acid Beta Oxidation36
9.5SLC25A20, LIPC, LPL
6
Show member pathways
thioredoxin pathway36
9.0GGT1, LDLR, APOB, ABCA1, APOA1
7
Show member pathways
fatty acid beta-oxidation VI (peroxisome)36
9.0APOC3, LPL, PLTP, PPARA, APOA2, APOA1
88.9LPL, LDLR, APOB, APOA2, APOC3, APOA1
9
Show member pathways
8.9LPL, LDLR, APOB, APOA2, APOC3, APOA1
10
Show member pathways
8.4PPARA, RORA, LPL, APOA2, SLC25A20, APOA1
11
Show member pathways
7.7ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
12
Show member pathways
7.3APOA2, APOA1, APOC3, ABCA1, APOB, LIPC
13
Show member pathways
5.1APOA2, GBA, LCAT, APOC3, PPARA, ABCA1

Compounds for genes affiliated with Hypoalphalipoproteinemia

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Compounds related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1psyllium439.6LCAT, APOB, LDLR, CETP
2fenofibric acid43 2810.4PPARA, APOA1, LPL, APOB, APOC3
3dimyristoylphosphatidylcholine439.4APOA2, LDLR, LPA, LCAT, APOA1
4ciprofibrate43 2810.3LDLR, PPARA, LPL, APOA1, APOB
5xbai439.3APOC3, APOB, LDLR, CETP, LPL
6ezetimibe43 1210.3APOA1, PPARA, ABCA1, CETP, LDLR, APOB
7cholestyramine439.3LDLR, CETP, APOC3, LPA, APOB
8rosuvastatin43 49 28 1212.2APOA1, PPARA, LDLR, CETP, APOB, APOC3
9hind iii439.2LIPC, LPA, LPL, ABCA1, APOC3
10dextran sulfate439.1APOA1, APOB, LDLR, CETP, LPL, PLTP
11sele439.1CETP, ACE, APOC3, LPL, LDLR
12stearic acid43 24 1211.0LIPC, LPL, CETP, LDLR, ABCA1, PPARA
13mspi439.0LPA, CETP, LDLR, APOB, APOA2, APOC3
14linoleic acid28 43 2410.9ABCA1, CETP, LDLR, LPL, LCAT, PPARA
15taurocholate438.9APOA1, APOC3, LPL, GBA, APOB
16palmitate438.9APOB, PPARA, LCAT, LPL, LDLR, CETP
17intralipid438.9APOA1, LCAT, LPL, CETP, LIPC, APOB
18carnitine438.8SLC25A20, PPARA, ABCA1, APOA1, APOB, LPL
19sterol438.8APOA1, CETP, LDLR, LIPC, APOB, ABCA1
20pioglitazone28 43 49 1211.6ABCA1, LPL, GGT1, LIPC, APOB, PPARA
21rosiglitazone28 43 49 24 1212.6PPARA, ABCA1, LPA, APOC3, APOB, LPL
22niacin43 129.6LPL, LPA, CETP, APOB, APOA1, ABCA1
23fluvastatin43 49 28 1211.6LDLR, APOA1, CETP, LPL, PPARA, ACE
24metformin43 49 1210.4APOB, GGT1, ACE, PPARA, LPL, APOA1
25probucol43 129.3LCAT, PLTP, LPL, CETP, LDLR, LIPC
26oleic acid43 28 24 1211.2LPA, CETP, LDLR, LIPC, APOB, ABCA1
27thyroxine43 249.2APOA1, APOB, LDLR, LIPC, CETP, LPA
28simvastatin43 49 59 28 24 1213.1LPA, CETP, LDLR, APOB, APOA1, ABCA1
29gemfibrozil28 43 1210.1LPA, LPL, CETP, LIPC, APOB, APOA2
30lovastatin43 49 59 28 1212.1APOA1, APOC3, APOB, GGT1, LPL, LPA
31triacylglycerol438.1LDLR, LIPC, APOB, APOA2, APOC3, APOA1
32alpha tocopherol438.0PPARA, ABCA1, GGT1, LCAT, PLTP, LPL
33phosphatidylcholine437.9ABCA1, APOA1, APOA2, APOB, LIPC, LDLR
34aspirin43 49 28 2410.8LPA, ACE, APOB, APOA1, ABCA1, CETP
35heparin43 28 24 1210.8LCAT, LPL, LPA, CETP, LDLR, APOB
36testosterone43 59 24 1210.7LIPC, APOA1, APOB, APOC3, ABCA1, PPARA
37phospholipid437.7APOB, CETP, LDLR, LIPC, APOA2, APOC3
38fenofibrate43 49 129.6PLTP, LPL, PPARA, ABCA1, LPA, CETP
39pravastatin43 49 28 24 1211.5LCAT, ACE, LPL, LPA, CETP, LDLR
40vitamin a43 24 129.5GGT1, LCAT, LPL, LPA, CETP, LIPC
41cholesterol ester437.4LCAT, PLTP, PPARA, ABCA1, APOA1, LPL
42estrogen437.3LCAT, PPARA, APOA1, LPL, APOC3, APOA2
43atorvastatin43 49 28 24 1211.2CETP, LDLR, LIPC, APOB, APOC3, APOA1
44fatty acid437.2PPARA, ABCA1, LPL, LPA, CETP, LDLR
45bezafibrate43 28 129.1ABCA1, PPARA, APOA1, APOC3, APOA2, GGT1
46creatinine437.1APOB, ACE, GGT1, PPARA, APOA1, APOC3
47serine436.8PPARA, ABCA1, APOC3, APOA2, APOB, LIPC
48glucose435.6PLTP, LPL, LPA, LIPC, RORA, GGT1
49cholesterol43 28 24 128.3LPA, LPL, ACE, PLTP, LCAT, RORA
50lipid434.9GBA, PPARA, GGT1, SLC25A20, RORA, LCAT

GO Terms for genes affiliated with Hypoalphalipoproteinemia

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Cellular components related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:00343639.9APOC3, APOB
2spherical high-density lipoprotein particleGO:00343669.8APOA2, APOA1, APOC3
3chylomicronGO:00426279.5APOC3, LPL, APOB, APOA2
4high-density lipoprotein particleGO:00343649.5LCAT, CETP, LIPC, APOA2, APOA1
5very-low-density lipoprotein particleGO:00343619.4APOC3, LPL, APOB, APOA2, APOA1
6early endosomeGO:00057699.1APOC3, APOA1, APOA2, APOB, LDLR
7extracellular spaceGO:00056157.7LPL, APOB, APOC3, LCAT, ACE, LIPC
8extracellular regionGO:00055767.5CETP, APOA2, LPL, APOA1, ACE, LPA

Biological processes related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipase activityGO:006019210.4APOA2, APOA1
2regulation of intestinal cholesterol absorptionGO:003030010.4APOA2, APOA1
3negative regulation of cholesterol importGO:006062110.4APOA2, APOC3
4cholesterol importGO:007050810.4LDLR, APOA1
5negative regulation of cytokine secretion involved in immune responseGO:000274010.3APOA1, APOA2
6protein oxidationGO:001815810.3APOA1, APOA2
7high-density lipoprotein particle clearanceGO:003438410.3APOA2, APOA1
8high-density lipoprotein particle assemblyGO:003438010.3APOA1, ABCA1, APOA2
9regulation of Cdc42 protein signal transductionGO:003248910.2APOC3, APOA1, ABCA1
10negative regulation of very-low-density lipoprotein particle remodelingGO:001090310.2APOA1, APOC3, APOA2
11peptidyl-methionine modificationGO:001820610.2APOA2, APOA1
12phospholipid homeostasisGO:005509110.2CETP, APOA1, ABCA1
13phosphatidylcholine biosynthetic processGO:000665610.2LCAT, APOA2, APOA1
14lipoprotein catabolic processGO:004215910.2LDLR, APOB
15triglyceride mobilizationGO:000664210.2APOC3, APOB
16chylomicron remnant clearanceGO:003438210.1LIPC, APOC3
17positive regulation of cholesterol esterificationGO:001087310.1APOA1, APOA2
18lipoprotein biosynthetic processGO:004215810.1APOA1, APOB, LCAT
19negative regulation of macrophage derived foam cell differentiationGO:001074510.1ABCA1, PPARA, CETP
20negative regulation of cholesterol storageGO:001088710.1PPARA, ABCA1
21phospholipid effluxGO:003370010.0APOA2, APOC3, APOA1, ABCA1
22response to estrogenGO:00436279.9APOA2, APOA1, GBA
23triglyceride metabolic processGO:00066419.9APOC3, APOA2, CETP, LPL
24low-density lipoprotein particle clearanceGO:00343839.9LDLR, APOB
25very-low-density lipoprotein particle remodelingGO:00343729.8LIPC, CETP, LPL, LCAT
26positive regulation of cholesterol storageGO:00108869.8LPL, APOB
27lipid transportGO:00068699.8LPA, PLTP, CETP
28low-density lipoprotein particle remodelingGO:00343749.8APOB, LIPC, CETP, APOA2
29response to nutrientGO:00075849.8APOC3, APOA1, ABCA1
30triglyceride catabolic processGO:00194339.7LPL, APOB, LIPC, APOC3
31cholesterol effluxGO:00333449.7APOA1, APOC3, APOA2, APOB, ABCA1
32response to drugGO:00424939.7APOC3, APOA1, ABCA1, APOA2, LPL
33cholesterol transportGO:00303019.6APOA1, APOB, CETP, LCAT, LDLR
34very-low-density lipoprotein particle assemblyGO:00343799.6APOC3, APOB
35negative regulation of inflammatory responseGO:00507289.6RORA, GBA, APOA1
36cellular lipid metabolic processGO:00442559.6SLC25A20, APOA2, APOA1, ABCA1, PPARA
37receptor-mediated endocytosisGO:00068989.5LDLR, LPA, CETP, APOB
38high-density lipoprotein particle remodelingGO:00343759.5CETP, LIPC, APOA2, APOC3, APOA1, LCAT
39lipid metabolic processGO:00066299.5PPARA, PLTP, LPA, LDLR
40retinoid metabolic processGO:00015239.4LPL, APOA1, APOC3, APOB, APOA2, LDLR
41phototransduction, visible lightGO:00076039.4APOA1, LPL, APOB, LDLR, APOC3, APOA2
42reverse cholesterol transportGO:00436919.3APOA2, LIPC, APOA1, ABCA1, CETP, LCAT
43triglyceride homeostasisGO:00703289.1CETP, APOA1, APOC3, LIPC, LPL, RORA
44cholesterol metabolic processGO:00082038.7ABCA1, APOA1, APOC3, APOA2, APOB, LIPC
45cholesterol homeostasisGO:00426328.7APOA2, APOB, ABCA1, APOA1, APOC3, LIPC
46lipoprotein metabolic processGO:00421577.9APOA2, LCAT, ABCA1, PPARA, LPL, LDLR
47small molecule metabolic processGO:00442816.6LCAT, LPL, LPA, CETP, GGT1, SLC25A20

Molecular functions related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I bindingGO:003418610.2ABCA1, LCAT
2apolipoprotein receptor bindingGO:003419010.1APOA2, APOA1
3triglyceride bindingGO:001712910.1LPL, CETP
4high-density lipoprotein particle receptor bindingGO:007065310.1APOC3, APOA2, APOA1
5lipase inhibitor activityGO:005510210.1APOA2, APOA1, APOC3
6high-density lipoprotein particle bindingGO:000803510.1APOA1, APOA2
7phospholipid transporter activityGO:000554810.1ABCA1, APOA1, CETP
8phosphatidylcholine-sterol O-acyltransferase activator activityGO:006022810.0APOA1, APOA2
9cholesterol bindingGO:00154859.7ABCA1, APOA1, APOC3, APOA2, CETP
10lipid bindingGO:00082899.6PPARA, APOA2, CETP, PLTP
11phospholipase activityGO:00046209.6LPL, LIPC
12cholesterol transporter activityGO:00171279.6APOB, APOA2, APOA1, ABCA1, CETP
13phospholipid bindingGO:00055439.6ABCA1, APOB, APOA1, APOC3, APOA2
14apolipoprotein bindingGO:00341859.5ABCA1, LPA, LPL, LIPC
15heparin bindingGO:00082019.2LPL, LPA, LIPC, APOB
16protein bindingGO:00055156.4LDLR, ACE, RORA, GGT1, LCAT, LPL

Products for genes affiliated with Hypoalphalipoproteinemia

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Sources for Hypoalphalipoproteinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet