Hypocalcemia malady

Wikipedia: In medicine, hypocalcaemia (or hypocalcemia) is the presence of low serum calcium levels in the blood,...⁴⁴ more...

MalaCards: Hypocalcemia is related to hypomagnesemia with secondary hypocalcemia and hypocalcemia, autosomal dominant. An important gene associated with Hypocalcemia is TRPM6 (transient receptor potential cation channel, subfamily M, member 6), and among its related pathways are Class B/2 (Secretin family receptors) and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs calcium carbonate pwdr [va product] and calcium carbonate and the compounds cinacalcet and alfacalcidol have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

hypocalcemia 7 32 43

Diseases related to hypocalcemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 336)

id	Related Disease	Score	Top Affiliating Genes
1	hypomagnesemia with secondary hypocalcemia	33.4	TRPM7, TRPM6
2	hypocalcemia, autosomal dominant	31.5	GRM1, CARS, CASR, PRKAR1A, CXADR
3	hypomagnesemia	31.0	CLDN16, BGLAP, ALB, CASR, TRPM7, TRPM6
4	familial hypocalciuric hypercalcemia	29.4	CASR, SPG7, NR1I3, CXADR
5	hypocalciuric hypercalcemia	28.6	CASR, CALCA, PTH, SPG7, NR1I3, PRKAR1A
6	paget's disease of bone	28.1	BGLAP, CALCA
7	calciphylaxis	27.4	PIK3C2A, ALB, CASR, PTHLH
8	celiac disease	27.1	VDR, BGLAP, CHKB, CD36, ALB, CALCA
9	thyrotoxicosis	26.4	BGLAP, CD36, ALB, ALPP, CALCA, SLPI
10	renal osteodystrophy	25.7	VDR, BGLAP, CD36, FGF23, ALPP, CASR
11	multiple myeloma	25.6	BGLAP, CD36, ALB, ALPP, CALCA, PTH
12	hyperphosphatemia	25.3	GCM2, VDR, BGLAP, FGF23, ALB, ALPP
13	hypoparathyroidism	25.2	PIK3C2A, GCM2, VDR, BGLAP, FGF23, ALPP
14	rickets	24.8	VDR, BGLAP, CD36, FGF23, ALB, ALPP
15	myeloma	24.5	VDR, BGLAP, CD36, IAPP, ALB, ALPP
16	pseudohypoparathyroidism	24.5	BGLAP, CHKA, APC, GNAS, CALCA, PTH
17	hypercalcemia	23.7	VDR, BGLAP, CD36, FGF23, GRM1, IAPP
18	twinning	23.7	VDR, BGLAP, CD36, APC, ALB, CARS
19	primary hyperparathyroidism	23.6	GCM2, VDR, BGLAP, CD36, FGF23, ALPP
20	hyperparathyroidism	23.5	GCM2, VDR, BGLAP, CD36, FGF23, IAPP
21	hypercalciuria	23.1	VDR, CLDN16, BGLAP, FGF23, ALB, CASR
22	hypothyroidism	21.2	PIK3C2A, VDR, BGLAP, CHKA, CHKB, CD36
23	hypoparathyroidism familial isolated	13.7	GCM2, PTH
24	hypoparathyroidism, autosomal dominant	13.7	GCM2, CASR, PTH
25	clear cell adenoma	13.6	ALPP, PTH
26	parathyroid disorders	13.6	PTH, PTHLH
27	parathyroid carcinoma	13.6	CASR, CALCA, PTH
28	hypercalciuria, absorptive	13.5	VDR, CASR
29	hyperparathyroidism, neonatal severe primary	13.5	CASR, NR1I3, PRKAR1A, CXADR
30	oncogenic osteomalacia	13.5	FGF23, CALCA, PTH
31	vitamin d-dependent rickets type ii	13.5	VDR, CYP27B1
32	x-linked hypophosphatemia	13.5	BGLAP, FGF23
33	dysgerminoma of ovary	13.5	ALPP, PTHLH
34	jansen's metaphyseal chondrodysplasia	13.4	FGF23, PTH, PTHLH
35	metaphyseal chondrodysplasia	13.4	FGF23, PTH, PTHLH
36	hypophosphatasia	13.4	ALPP, CALCA, SLPI
37	hyperostosis	13.4	BGLAP, FGF23, PTH
38	progressive osseous heteroplasia	13.4	BGLAP, ALPP, GNAS
39	giant cell tumor	13.4	BGLAP, FGF23, CALCA
40	panhypopituitarism	13.3	BGLAP, ALPP, CALCA
41	orthostatic hypotension	13.3	ALB, GNAS, CALCA
42	cushing's syndrome	13.3	BGLAP, GNAS, CALCA, PRKAR1A
43	familial male-limited precocious puberty	13.3	BGLAP, GRM1, GNAS, CALCA
44	hypervitaminosis d	13.3	VDR, FGF23, PTH, CYP27B1
45	transsexualism	13.3	VDR, BGLAP, CALCA
46	obstructive lung disease	13.3	ALB, CALCA, SLPI
47	pseudohypoparathyroidism type 1b	13.3	GNAS, PTHLH, STX16
48	multinodular goiter	13.2	GNAS, CALCA, ADCY10
49	short-chain acyl-coa dehydrogenase deficiency	13.2	PIK3C2A, CHKA
50	high blood pressure	13.2	BGLAP, ALB, PTH

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 calcitriol, calcium (as calcium carbonate), calcium (as carbonate), calcium (as citrate), calcium acetate, calcium carbonate, calcium carbonate pwdr [va product], calcium citrate, calcium glubionate, calcium glycerophosphate, calcium lactate, calcium levulinate, calcium pantothenate, calcium phosphate, cod liver oil [va product], dihydrotachysterol

MalaCards organs/tissues related to hypocalcemia:

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MGI Mouse Phenotypes related to hypocalcemia:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	PRKAR1A, PTH, GNAS, GCM2
2	craniofacial phenotype	MP:0005382	9.8	GCM2, GNAS, TRPM6, PRKAR1A, PTH
3	limbs/digits/tail phenotype	MP:0005371	9.1	VDR, FGF23, CHKB, GNAS, PTH, PTHLH
4	hematopoietic system phenotype	MP:0005397	8.8	FGF23, PRKAR1A, PTHLH, PTH, TRPM7, CASR
5	adipose tissue phenotype	MP:0005375	8.2	PIK3C2A, CD36, GRM1, GNAS, PTHLH, PRKAR1A
6	renal/urinary system phenotype	MP:0005367	8.1	CLDN16, PTHLH, GNAS, APC, SLC12A3, CYP27B1
7	reproductive system phenotype	MP:0005389	8.0	NR1I3, ADCY10, PRKAR1A, ALPP, APC, GRM1
8	skeleton phenotype	MP:0005390	7.5	PTHLH, GCM2, FGF23, VDR, GRM1, CYP27B1
9	muscle phenotype	MP:0005369	7.5	GNAS, CASR, PRKAR1A, APC, CXADR, GRM1
10	digestive/alimentary phenotype	MP:0005381	7.2	VDR, FGF23, APC, ALB, CD36, GAST
11	growth/size phenotype	MP:0005378	7.1	PTH, GNAS, PRKAR1A, NR1I3, SPG7, CYP27B1
12	cardiovascular system phenotype	MP:0005385	7.0	GNAS, VDR, HADHA, ADCY10, SLC12A3, PRKAR1A
13	mortality/aging	MP:0010768	6.6	PTH, PIK3C2A, VDR, CD36, FGF23, NR1I3
14	immune system phenotype	MP:0005387	6.3	IAPP, GNAS, CASR, PTH, PTHLH, CYP27B1
15	homeostasis/metabolism phenotype	MP:0005376	3.8	CHKB, PRKAR1A, NR1I3, CYP27B1, PTHLH, TRPM6

Articles related to hypocalcemia:

(show top 50)    (show all 64)

id	Title	Authors	Year	Affiliating Genes
1	Autosomal dominant hypocalcemia caused by an activati ng mutation of the calcium-sensing receptor gene: the first case report in Kore a. (20119591)	Kim M.Y.... Chung J.H.	2010	CASR
2	Irreversible end-stage heart failure in a young patie nt due to severe chronic hypocalcemia associated with primary hypoparathyroidis m and celiac disease. (20043335)	Mavroudis K.... Antonakoudis C.	2010	CHKB
3	Hypocalcemia impacts heart failure control in DiGeorge 2 syndrome. (18795911)	Chao P.H.... Chung M.Y.	2009	C22DDELS
4	Novel gain of function mutations of the calcium-sensi ng receptor in two patients with PTH-deficient hypocalcemia. (19915295)	Nakajima K.... Sato K.	2009	CASR
5	Hypocalcemia and tetany caused by vitamin D deficienc y in a child with intestinal lymphangiectasia. (19864203)	Lu Y.Y.... Chang M.H.	2009	ALB
6	Amikacin-induced type 5 Bartter-like syndrome with se vere hypocalcemia. (19884751)	Chrispal A.... Moses V.	2009	CASR
7	Autosomal dominant hypoparathyroidism with severe hypomagnesemia and hypocalcemia, successfully treated with recombinant PTH and continuous subcutaneous magnesium infusion. (18556971)	Sanda S.... Newfield R.S.	2008	CASR
8	A case of hypomagnesemia with secondary hypocalcemia caused by Trpm6 gene mutation. (18759094)	Apa H.... Berdeli A.	2008	TRPM6
9	Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia. (18037250)	Pereira L.C.... de Paula F.J.	2008	BGLAP
10	Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. (17197439)	Chubanov V.... Gudermann T.	2007	TRPM7, TRPM6
11	Hypocalcemia after alendronate therapy in a patient w ith celiac disease. (17669718)	Meek S.E.... Nix K.	2007	CALCA
12	Severe hypocalcemia following bisphosphonate treatmen t in a patient with Paget's disease of bone. (16769264)	Whitson H.E.... Lyles K.W.	2006	CALCA
13	Bisphosphonate-induced hypocalcemia associated with v itamin D deficiency in a patient with advanced cancer. (16225361)	Broadbent A.... Crawford B.	2005	ALB
14	Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. (16107578)	Schlingmann K.P.... Konrad M.	2005	TRPM6
15	A novel mutation (E767K) in the second extracellular loop of the calcium sensing receptor in a family with autosomal dominant hypocalcemia. (15551332)	Uckun-Kitapci A.... Moats-Staats B.	2005	CASR
16	Severe hypocalcemia and hypomagnesemia in a 14-year-old boy--difficulties in treatment related to silent coeliac disease (16232374)	Stacha W.... Niedziela M.	2005	CASR
17	Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (14976260)	Chubanov V.... Gudermann T.	2004	TRPM7, TRPM6
18	Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor. (15005845)	Hu J.... Spiegel A.M.	2004	PRKAR1A, CARS
19	Post-thyroidectomy hypocalcemia (15960355)	Costanzo M.... Cannizzaro M.A.	2004	CALCA
20	CASRdb: calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. (15241791)	Pidasheva S.... Hendy G.N.	2004	CASR
21	Albumin-adjusted calcium is not suitable for diagnosis of hyper- and hypocalcemia in the critically ill. (12771607)	Slomp J.... Bakker A.J.	2003	ALB
22	Autosomal dominant hypocalcemia: a novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor. (12574188)	Tan Y.M.... Conigrave A.D.	2003	CASR
23	A family of autosomal dominant hypocalcemia with an activating mutation of calcium-sensing receptor gene. (12733714)	Chikatsu N.... Fujita T.	2003	CASR
24	Recurrent familial hypocalcemia due to germline mosaicism for an activating mutation of the calcium-sensing receptor gene. (12915654)	Hendy G.N.... Cole D.E.	2003	CASR
25	A family of autosomal dominant hypocalcemia with a positive correlation between serum calcium and magnesium: identification of a novel gain of function mutation (Ser(820)Phe) in the calcium-sensing receptor. (12050233)	Nagase T.... Yamamoto M.	2002	CASR
26	Calciphylaxis, proteases, and purpura: an alternative hypothesis for the severe shock, rash, and hypocalcemia associated with meningococcal septicemia. (12483069)	Holland P.C.... Hodge D.	2002	ALB
27	Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. (12032570)	Walder R.Y.... Sheffield V.C.	2002	TRPM6
28	Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. (12032568)	Schlingmann K.P.... Konrad M.	2002	TRPM6
29	Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. (11889203)	D'Souza-Li L.... Hendy G.N.	2002	CASR
30	A novel activating mutation (C129S) in the calcium-sensing receptor gene in a Japanese family with autosomal dominant hypocalcemia. (11289719)	Hirai H.... Okada S.	2001	CASR
31	Activating mutations of the calcium-sensing receptor: management of hypocalcemia. (11701698)	Lienhardt A.... GarabAcdian M.	2001	CASR, NR1I3
32	Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. (11013439)	Hendy G.N.... Cole D.E.	2000	CASR
33	Calcium supplement necessary to correct hypocalcemia after total parathyroidectomy for renal osteodystrophy. (10710245)	Nakagawa M.... Nomura Y.	2000	PTH, SLPI
34	The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows. (11075539)	Liesegang A.... Wanner M.	2000	CD36
35	Three novel activating mutations in the calcium-sensing receptor responsible for autosomal dominant hypocalcemia. (11136551)	Conley Y.P.... Ferrell R.E.	2000	CASR
36	A large homozygous or heterozygous in-frame deletion within the calcium-sensing receptor's carboxylterminal cytoplasmic tail that causes autosomal dominant hypocalcemia. (10770217)	Lienhardt A.... Kottler M.L.	2000	CASR
37	A novel activating mutation in calcium-sensing receptor gene associated with a family of autosomal dominant hypocalcemia. (9920108)	Okazaki R.... Fukumoto S.	1999	CASR
38	Hypocalcemia in piglets reduces cardiac and pulmonary vascular disturbance after hypoxemia and reoxygenation during cardiopulmonary bypass. (10599958)	Baretti R.... Young H.H.	1999	CHKA
39	Hypocalcemia induced during major and minor abdominal surgery in humans. (10443655)	Lepage R.... D'Amour P.	1999	ALB
40	Primary hypothyroidism revealing pseudohypoparathyro idism without hypocalcemia and hyperphosphoremia (9230993)	Coutant R.... Chaussain J.L.	1997	APC
41	A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. (8813042)	Pearce S.H.S.... Thakker R.V.	1996	CASR
42	Post-thyroidectomy hypocalcemia: the role of calcitonin, parathormone and serum albumin. (9239811)	Cakmakli S.... Torun N.	1996	ALB, CALCA
43	Effect of hypocalcemia on muscle in disorders of calcium metabolism. (7645390)	Ishikawa T.... Watanabe I.	1995	CHKB
44	Risk factors for postthyroidectomy hypocalcemia. (7940161)	McHenry C.R.... Murphy T.	1994	CALCA
45	Thyrotoxicosis and hungry bone syndrome--a cause of posttreatment hypocalcemia. (8200118)	Dembinski T.C.... Blandford D.E.	1994	ALPP
46	Transient hypocalcemia after thyroidectomy (8072706)	Sortino N.... Miccoli P.	1994	BGLAP
47	A new in vitro bioassay for human calcitonin: validation and comparison to the rat hypocalcemia bioassay. (1316197)	Grauer A.... Ziegler R.	1992	CALCA, ADCY10
48	Evaluation of osteoclastic activity in multiple myeloma: results of a randomized trial studying hypocalcemia induced by human and salmon calcitonin in 49 patients (2057701)	Fuzibet J.G.... Peyron R.	1991	CALCA
49	Hypocalcemia after total thyroidectomy. Therapeutic considerations (2287468)	Piazza L.... Cannizzaro M.A.	1990	CALCA
50	Hypocalcemia and hypercalcitoninemia in critically ill children. (2225888)	Gauthier B.... Schaeffer J.	1990	CALCA, GAST

Genes related to hypocalcemia according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	TRPM6	transient receptor potential cation channel, subfamily M, member 6	11.1	Publications, Summaries, Aliases & Descriptions
2	DGCR	DiGeorge syndrome chromosome region	11.1	Summaries
3	CASR	calcium-sensing receptor	11.0	Publications
4	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
5	CXADR	coxsackie virus and adenovirus receptor	11.0
6	CARS	cysteinyl-tRNA synthetase	11.0	Publications
7	GRM1	glutamate receptor, metabotropic 1	11.0	Publications
8	GCM2	glial cells missing homolog 2 (Drosophila)	11.0
9	CLDN16	claudin 16	11.0
10	PTH	parathyroid hormone	11.0	Publications
11	TRPM7	transient receptor potential cation channel, subfamily M, member 7	11.0	Publications
12	GNAS	GNAS complex locus	11.0
13	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
14	SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	11.0	Publications
15	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
16	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0
17	FGF23	fibroblast growth factor 23	11.0
18	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0
19	IAPP	islet amyloid polypeptide	11.0
20	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
21	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
22	PTHLH	parathyroid hormone-like hormone	11.0	Publications
23	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
24	ALPP	alkaline phosphatase, placental	11.0	Publications
25	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
26	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
27	ALB	albumin	11.0	Publications
28	C22DDELS	Chromosome 22q11.2 deletion syndrome, distal	11.0	Publications
29	STX16	syntaxin 16	11.0
30	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
31	CHKB	choline kinase beta	11.0	Publications
32	CHKA	choline kinase alpha	11.0	Publications
33	GAST	gastrin	11.0	Publications
34	APC	adenomatous polyposis coli	11.0	Publications
35	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications

Pathways related to hypocalcemia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Class B/2 (Secretin family receptors)38	9.8	GNAS, CALCA, PTH, PTHLH
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.3	GNAS, PRKAR1A, PTHLH, PTH, BGLAP, VDR
3	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.3	BGLAP, CALCA, PTH, CYP27B1, VDR
4	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.3	VDR, BGLAP, GNAS, PTH, PTHLH, PRKAR1A
5	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	BGLAP, VDR, CYP27B1, PTH, CALCA

Compounds related to hypocalcemia according to GeneDecks:

(show top 50)    (show all 156)

id	Compound	Score	Top Affiliating Genes
1	cinacalcet32 9 9	12.0	NR1I3, CALCA, CASR, CXADR, PRKAR1A
2	alfacalcidol32 9 9	11.7	CALCA, CYP27B1, SLPI, BGLAP, VDR
3	ipriflavone32	9.5	BGLAP, SLPI, ALPP, CALCA
4	sevelamer32	9.5	BGLAP, FGF23, ALB, CASR
5	24,25-dihydroxyvitamin d332	9.4	ALPP, CALCA, ADCY10, BGLAP, VDR, CYP27B1
6	estradiol32 9 18 9	12.4	IAPP, CHKA, CHKB, SLPI
7	etidronate32	9.3	ALPP, CALCA, SLPI, CD36, BGLAP
8	calcium carbonate32	9.2	CD36, BGLAP, ALPP, CALCA, PTH, PTHLH
9	22-oxacalcitriol32	9.2	VDR, CD36, ALPP, CASR, PTHLH, BGLAP
10	hydrochlorothiazide32 34 9 18 9	13.2	CLDN16, BGLAP, ALB, SLC12A3, CASR, VDR
11	pamidronate32 9 9	11.1	ALPP, CD36, CALCA, PTHLH, BGLAP, CASR
12	tartrate32	9.1	BGLAP, CD36, PTHLH, ALPP, CALCA, SLPI
13	vitamin k232	9.1	CD36, SLPI, BGLAP, ALPP, CALCA
14	risedronate32 42 9 9	12.1	SLPI, CALCA, ALPP, CD36, BGLAP
15	neomycin32	9.1	ALPP, PRKAR1A, PTHLH, CASR, GAST, NR1I3
16	pyridinoline32	9.1	PTHLH, CALCA, ALPP, BGLAP, CD36, SLPI
17	clodronate32 9 9	11.0	BGLAP, SLPI, PTHLH, CALCA, CD36
18	phosphorus32	9.0	SLPI, PTH, CALCA, CASR, ALPP, FGF23
19	deoxypyridinoline32	9.0	ALPP, CD36, VDR, CALCA, PTH, SLPI
20	zoledronic acid32	9.0	BGLAP, PTHLH, ALPP, CD36, CALCA, SLPI
21	creatinine32	8.9	SPG7, PTHLH, PTH, CASR, FGF23, CHKA
22	hydroxyproline32 18	9.9	CD36, ALPP, CALCA, PTH, PTHLH, SLPI
23	hydroxyapatite32	8.8	BGLAP, CD36, FGF23, ALPP, CASR, PTHLH
24	alendronate32 9 9	10.8	PTHLH, VDR, PTH, SLPI, CALCA, ALPP
25	1,25 dihydroxy vitamin d332	8.7	CYP27B1, NR1I3, CXADR, CASR, PTHLH, VDR
26	glucose32	8.5	HADHA, PTH, PTHLH, CASR, GAST, PRKAR1A
27	pge232	8.5	GAST, ADCY10, SLPI, CYP27B1, CASR, GNAS
28	isoproterenol32 9 9	10.3	GAST, ADCY10, PTHLH, PTH, GNAS, IAPP
29	cysteine32	8.3	VDR, CASR, CYP27B1, CARS, ALPP, SLPI
30	glutamate32	8.2	HADHA, ADCY10, CXADR, PRKAR1A, NR1I3, SPG7
31	forskolin32 42 9 9	11.0	APC, IAPP, GNAS, CASR, CALCA, GRM1
32	25-hydroxyvitamin d32	8.0	FGF23, CD36, BGLAP, VDR, PTH, PTHLH
33	potassium32 9 18 9	10.8	PIK3C2A, PTHLH, SLPI, GRM1, ALB, CASR
34	arginine32	7.6	PTHLH, PRKAR1A, PTH, GNAS, ADCY10, PIK3C2A
35	magnesium32 9 18 9	10.5	ALB, APC, CLDN16, PIK3C2A, ALPP, CASR
36	thymidine32 18	8.4	VDR, GNAS, PTH, CHKA, NR1I3, CXADR
37	thyroxine32 18	8.4	CHKB, PIK3C2A, VDR, BGLAP, CHKA, ALB
38	cyclic amp32 18	8.3	PTHLH, ADCY10, SLPI, PRKAR1A, PTH, CALCA
39	norepinephrine32 9 18 9	10.1	IAPP, GAST, ADCY10, SLPI, CALCA, GNAS
40	ascorbic acid32 18	8.0	ALPP, GAST, SLPI, CHKA, ALB, CHKB
41	calcitriol32 42 9 18 9	10.8	GAST, SLPI, BGLAP, VDR, CD36, FGF23
42	adenylate32	6.6	PTH, PTHLH, PRKAR1A, CXADR, ADCY10, GAST
43	dexamethasone32 42 34 9 9	10.4	SLPI, VDR, BGLAP, CHKA, CHKB, CD36
44	heparin32 9 18 9	9.3	IAPP, SLPI, CXADR, PTHLH, ALPP, ALB
45	alanine32	6.2	SLPI, CXADR, PIK3C2A, VDR, BGLAP, CHKA
46	estrogen32	5.8	VDR, GAST, SLPI, NR1I3, CYP27B1, PTHLH
47	testosterone32 9 18 9	8.8	IAPP, GAST, SLPI, NR1I3, CYP27B1, PIK3C2A
48	serine32	5.2	BGLAP, CASR, IAPP, APC, TRPM6, GNAS
49	vitamin d32	4.8	CALCA, CASR, CARS, ALPP, ALB, APC
50	calcium32 9 18 9	5.6	GAST, HADHA, ADCY10, SLC12A3, SLPI, CXADR

Cellular components related to hypocalcemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.8	PTHLH, PTH, CALCA, ALB, IAPP, FGF23
2	extracellular region	GO:005576	7.5	BGLAP, GAST, SLPI, CXADR, PTHLH, PTH

Biological processes related to hypocalcemia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	vitamin D catabolic process	GO:042369	10.1	FGF23, CYP27B1
2	cAMP metabolic process	GO:046058	10.1	PTH, PTHLH
3	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	10.0	CYP27B1, FGF23, VDR
4	cellular calcium ion homeostasis	GO:006874	9.9	PTH, CASR, VDR, GCM2
5	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	9.9	PTH, CALCA, PTHLH
6	positive regulation of cAMP biosynthetic process	GO:030819	9.8	PTHLH, PTH, CALCA
7	skeletal system development	GO:001501	9.2	VDR, PTHLH, PTH, BGLAP

Molecular functions related to hypocalcemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ethanolamine kinase activity	GO:004305	9.5	CHKA, CHKB
2	choline kinase activity	GO:004103	9.2	CHKA, CHKB
3	hormone activity	GO:005179	9.0	IAPP, CALCA, PTH, PTHLH, GAST