MCID: HYP054
MIFTS: 45

Hypochromic Anemia malady

Summaries for Hypochromic Anemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes)... more...

MalaCards: Hypochromic Anemia, also known as anemia hypochromic, is related to hypochromic microcytic anemia and microcytic anemia. An important gene associated with Hypochromic Anemia is ALAS2 (aminolevulinate, delta-, synthase 2), and among its related pathways are Glucuronidation and O2/CO2 exchange in erythrocytes. The compounds 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine and 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and bone, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Hypochromic Anemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

hypochromic anemia 8 10
anemia hypochromic 8 44
hereditary sideroblastic anemia 60
hypochromic anaemia 8


External Ids:

Disease Ontology8 DOID:11759
NCIt39 C34380
SNOMED-CT56 44452003
MeSH34 D000747

Related Diseases for Hypochromic Anemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypochromic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1hypochromic microcytic anemia31.0HBB, TF
2microcytic anemia31.0TF, TFRC, ALAS2
3iron deficiency anemia30.7TFRC, TF, FECH
4deficiency anemia30.7ALAS2, FECH, TF, TFRC, HBB, HBA1
5alpha thalassemia30.3HBB, HBA1
6hemochromatosis30.3TF, TFRC
7sideroblastic anemia30.1TFRC, ALAS2
8macrocytic anemia30.1ALAS2, TF
9hemoglobinopathy30.1TF, TFRC, HBB
10beta thalassemia30.1TF, TFRC, HBB
11hemolytic anemia30.1HBB, TFRC, TF
12thalassemia10.4
13hemosiderosis10.2
14pyridoxine-refractory autosomal recessive sideroblastic anemia10.2
15x-linked sideroblastic anemia with ataxia10.2
16neurofibrosarcoma10.1
17cheilitis10.1
18x-linked sideroblastic anemia10.1
19myoma10.1
20rosacea10.1
21thrombocytosis10.1
22celiac disease10.1
23acne10.1
24leukemia10.1
25myeloid leukemia10.1
26renal cell carcinoma10.1
27benjamin syndrome10.1
28iron-refractory iron deficiency anemia10.1
29hypochromic microcytic anemia with iron overload 210.1
30galactosemia10.0TF
31friedreich ataxia10.0TFRC, SLC25A28
32congenital porphyria10.0ALAD, FECH
33hereditary coproporphyria10.0FECH, ALAD
34acute porphyria10.0ALAD, FECH
35polycythemia10.0TFRC, HBB
36erythropoietic protoporphyria10.0ALAS2, ALAD, FECH
37hydrops fetalis10.0HBB
38acute intermittent porphyria10.0FECH, ALAD
39variegate porphyria10.0FECH, ALAD
40tuberculosis10.0HBB
41refractory anemia10.0ALAS2, TFRC
42siderosis10.0TFRC, TF
43malaria10.0TFRC, HBB, ALAD
44iron metabolism disease10.0HBB, TFRC, TF
45porphyria10.0FECH, TF, ALAD, ALAS2
46porphyria cutanea tarda10.0FECH, TF, TFRC, ALAD
47sickle cell disease10.0ALAS2, HBB, TFRC, TF
48proliferative vitreoretinopathy10.0TFRC, TF
49acute erythroid leukemia10.0FECH, TF, TFRC, HBB, ALAS2

Graphical network of the top 20 diseases related to Hypochromic Anemia:



Diseases related to hypochromic anemia

Clinical Features for Hypochromic Anemia

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Drugs & Therapeutics for Hypochromic Anemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypochromic Anemia

Search CenterWatch for Hypochromic Anemia

Genetic Tests for Hypochromic Anemia

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Anatomical Context for Hypochromic Anemia

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32MalaCards
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MalaCards organs/tissues related to Hypochromic Anemia:

32
Liver, Bone marrow, Bone, Whole blood, Brain, Myeloid

Animal Models for Hypochromic Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypochromic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.1SLC25A37, NDFIP1, HBB, NCKAP1L, TFRC, FECH
2MP:00107717.9NDFIP1, TFRC, FECH, HBB, ALAS2, SLC25A37
3MP:00053877.2SLC25A37, HBB, NCKAP1L, TFRC, FECH, NDFIP1
4MP:00053976.7ALAS2, SLC25A37, HBB, NCKAP1L, TFRC, NDFIP1
5MP:00107686.7FECH, ALAS2, SLC25A37, HBA1, TFRC, HBB
6MP:00053766.6TF, EXOC6, NDFIP1, FECH, TFRC, NCKAP1L

Publications for Hypochromic Anemia

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50PubMed
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Articles related to Hypochromic Anemia:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
I+-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with I^-thalassemia, iron deficiency anemia. (22475300)
2012
2
Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia. (19205647)
2009
3
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. (19579082)
2009
4
Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats. (19797861)
2009
5
A differential diagnosis of microcytic hypochromic anemia for high-risk patients. (19570166)
2009
6
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. (18552213)
2008
7
Hypochromic microcytic anemia as a clinical presentation of celiac disease. (16812948)
2006
8
Genotyping of alpha-thalassemia in microcytic hypochromic anemia patients from North India. (17132905)
2006
9
A 16-year-old girl with hypochromic microcytic anemia. (16253038)
2005
10
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. (15994289)
2005
11
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. (15121718)
2004
12
A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma. (14513774)
2003
13
Quantitative determinations of microcytic-hypochromic red blood cell population and glycerol permeability in iron-deficiency anemia and beta thalassemia minor. (10550558)
1999
14
Low plasma cholesterol: a correlate of nondiagnosed celiac disease in adults with hypochromic anemia. (10406254)
1999
15
Effects of high-dose vitamin B6 therapy on microcytic and hypochromic anemia in hemodialysis patients. (8255009)
1993
16
Hypocupremia-related hypochromic anemia during D-penicillamine treatment. (7066031)
1982
17
Growth and maturation arrest, hypochromic anemia and hyperglobulinemia associated with a brain tumor. (7233896)
1980
18
Iron and hypochromic anemia. (788038)
1975
19
An investigation on the psychopathology of pica and hypochromic anemia. (4770545)
1973
20
Refractory hypochromic anemia in malignant lymphoma. (5450283)
1970
21
Heme synthesis and hypochromic anemia. (5764831)
1969
22
The iron content of gastric juice: in relation to the cause of idiopathic hypochromic anemia. (4230849)
1967
23
Severe hypochromic anemia in a newborn, due to fetal-maternal transfusion. (5949644)
1966
24
Hereditary hypochromic microcytic anemia in the laboratory rat. (5958911)
1966
25
ROENTGENOGRAPHIC FINDINGS IN TWO PATIENTS WITH HYPOCHROMIC ANEMIA. (14146008)
1964
26
Intriguing types of hypochromic anemia. (14024424)
1963
27
XANTHOFIBROMA OF THE STOMACH. REPORT OF A CASE WITH SEVERE SECONDARY HYPOCHROMIC ANEMIA. (14087280)
1963
28
An iron, pyridoxine and ascorbic acid combination in the treatment of hypochromic anemia. (14021886)
1963
29
Hereditary hypochromic microcytic anemia in obstetrics and gynecology. (14488836)
1962
30
Hemoglobin synthesis with iron choline citrate in hypochromic anemia of pregnancy. (13722597)
1960
31
The development of the use of iron in hypochromic anemia. (13649708)
1959
32
HYPOCHROMIC anemia of infancy. (13613630)
1959
33
Hypochromic microcytic anemia of infancy; iron depletion as a factor. (13378924)
1956
34
Maternal factors in hypochromic anemia of infancy. (13366657)
1956
35
Parenterally administered iron in the treatment of hypochromic anemia. (13359502)
1956
36
Supplementary notes on anemia in pregnant women; on the origin and treatment of microcytic hypochromic anemia during toxemias in pregnancy. (13252298)
1955
37
Treatment of hypochromic anemia with an intramuscular iron-dextran complex. (13268094)
1955
38
The pathogenesis of hypochromic microcytic anemia. (13163531)
1954
39
Use of ferric and ferrous iron in the prevention of hypochromic anemia in infants. (13103769)
1953
40
Hypochromic and macrocytic anemia due to Anguillula intestinalis infestation, simulating saturnine anemia]. (13134861)
1953
41
Hypochromic anemia in the aged. (14890306)
1951
42
Intravenously administered saccharated iron oxide in the treatment of hypochromic anemia; therapeutic results, potential dangers and indications. (14774236)
1950
43
Treatment of iron deficiency (hypochromic anemia). (18909741)
1948
44
Is the broad tape-worm the casual agent of hypochromic anemia? (18919070)
1947
45
Hypochromic anemia; treatment with molybdenum-iron complex. (20989994)
1946
46
Observations on the effect of massive doses of iron given intravenously to patients with hypochromic anemia. (21015976)
1946
47
Observations on the effect of massive doses of iron given intravenously to patients with hypochromic anemia. (21021594)
1945
48
Hypochromic anemia with epithelial changes and acne rosacea. (21005788)
1945
49
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA. (16694502)
1937
50
QUANTITATIVE ASPECTS OF IRON DEFICIENCY IN HYPOCHROMIC ANEMIA: (The Parenteral Administration of Iron). (16694103)
1932

Genetic Variations for Hypochromic Anemia

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Expression for genes affiliated with Hypochromic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypochromic Anemia

Search GEO for disease gene expression data for Hypochromic Anemia.

Pathways for genes affiliated with Hypochromic Anemia

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Hypochromic Anemia

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11DrugBank, 44Novoseek, 24HMDB, 28IUPHAR
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Compounds related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
14-[(5-methoxy-2-methylphenoxy)methyl]pyridine1110.3HBA1, HBB
22-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID1110.3HBA1, HBB
3SEBACIC ACID1110.3HBA1, HBB
41,3,5-BENZENETRICARBOXYLIC ACID1110.3HBA1, HBB
52,6-DICARBOXYNAPHTHALENE1110.3HBB, HBA1
64-Carboxycinnamic Acid1110.3HBA1, HBB
72-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID1110.3HBA1, HBB
82-[(2-methoxy-5-methylphenoxy)methyl]pyridine1110.3HBA1, HBB
9ppix4410.2FECH, TFRC
10protoporphyrinogen4410.2FECH, ALAD
11aluminium citrate4410.2TFRC, TF
12ethylenediaminetetraacetic acid4410.2FECH, ALAD
13gallium4410.2TFRC, TF
14deferiprone4410.2TF, TFRC
15porphyrin4410.2ALAD, FECH
16aluminium44 1111.2TF, TFRC
17apotransferrin4410.1TFRC, TF
18bismuth44 2411.1TFRC, TF
19ferric ammonium citrate4410.1TFRC, TF
20formyl-coa44 2411.1FECH, ALAD, ALAS2
21benzidine4410.1HBB, TFRC
22fe3+4410.0TFRC, TF, FECH
23haem4410.0FECH, ALAS2
24fe2+449.9FECH, TF, TFRC
25deferoxamine44 1110.9TFRC, TF, FECH
26tbps44 2810.9TF, TFRC
27vitamin b12449.9ALAD, TFRC, TF
28nh4cl449.8TFRC, TF
29copper44 2410.7FECH, TF, ALAD
30porphobilinogen44 11 2411.7ALAD, HBB, TFRC, FECH
31zinc protoporphyrin449.7FECH, TF, TFRC, ALAD
32iron dextran44 1110.7TF, TFRC, HBB, HBA1
33iron-sulfur449.7ALAS2, FECH
34succinylacetone449.6ALAD, HBB, TFRC, TF
35glutamine449.5TF, TFRC, HBB, ALAS2
365-aminolevulinic acid44 2410.5ALAS2, ALAD, HBB, TFRC, FECH
37dmso449.5HBB, TFRC, FECH
38protoporphyrin ix44 11 2411.5FECH, TF, TFRC, ALAD, ALAS2
39lactate449.4ALAD, HBB, TFRC, TF
40aspartate449.4ALAS2, HBB, TFRC, TF
41alanine449.3FECH, TF, TFRC, HBB, ALAS2
42heme28 11 2410.3ALAS2, FECH, TF, HBB, HBA1, SLC25A37
43iron44 249.0FECH, TF, TFRC, HBB, HBA1, SLC25A37

GO Terms for genes affiliated with Hypochromic Anemia

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16Gene Ontology
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Cellular components related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057438.8ALAS2, SLC25A28, SLC25A37, FECH
2perinuclear region of cytoplasmGO:0484718.8TFRC, TF, NDFIP2, NDFIP1

Biological processes related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:0067789.9ALAS2, ALAD, FECH
2heme biosynthetic processGO:0067839.9FECH, ALAD, ALAS2
3protoporphyrinogen IX biosynthetic processGO:0067829.9ALAD, ALAS2
4transferrin transportGO:0335729.8TFRC, TF
5negative regulation of protein transportGO:0512249.5NDFIP2, NDFIP1
6iron ion homeostasisGO:0550729.5SLC25A28, SLC25A37, FECH
7negative regulation of transporter activityGO:0324109.4NDFIP2, NDFIP1
8erythrocyte differentiationGO:0302189.3EXOC6, FECH, ALAS2
9cellular iron ion homeostasisGO:0068799.2ALAS2, TFRC, TF, NDFIP1
10small molecule metabolic processGO:0442818.2FECH, HBB, SLC25A37, SLC25A28, ALAD, ALAS2

Molecular functions related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1WW domain bindingGO:0506999.4NDFIP2, NDFIP1

Products for genes affiliated with Hypochromic Anemia

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Sources for Hypochromic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet