MCID: HYP054
MIFTS: 44

Hypochromic Anemia malady

Summaries for Hypochromic Anemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes)... more...

MalaCards: Hypochromic Anemia, also known as anemia hypochromic, is related to hypochromic microcytic anemia and iron deficiency anemia. An important gene associated with Hypochromic Anemia is ALAS2 (aminolevulinate, delta-, synthase 2), and among its related pathways are Glucuronidation and O2/CO2 exchange in erythrocytes. The compounds 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine and 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone marrow, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Hypochromic Anemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

hypochromic anemia 8 10
anemia hypochromic 8 45
hereditary sideroblastic anemia 61
hypochromic anaemia 8


External Ids:

Disease Ontology8 DOID:11759
NCIt40 C34380
SNOMED-CT57 44452003
MeSH35 D000747

Related Diseases for Hypochromic Anemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypochromic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1hypochromic microcytic anemia31.1TF, HBB
2iron deficiency anemia30.6FECH, TF, TFRC
3deficiency anemia30.6FECH, TF, TFRC, HBB, HBA1, ALAD
4thalassemia30.6HBA1, HBB, TFRC, TF
5alpha thalassemia30.3HBB, HBA1
6hemochromatosis30.3TF, TFRC
7refractory anemia30.1TFRC, ALAS2
8beta thalassemia30.1TFRC, TF, HBB
9hemosiderosis10.3
10pyridoxine-refractory autosomal recessive sideroblastic anemia10.2
11x-linked sideroblastic anemia with ataxia10.2
12neurofibrosarcoma10.1
13x-linked sideroblastic anemia10.1
14myoma10.1
15rosacea10.1
16thrombocytosis10.1
17celiac disease10.1
18acne10.1
19turner syndrome10.1
20benjamin syndrome10.1
21iron-refractory iron deficiency anemia10.1
22hypochromic microcytic anemia with iron overload 210.1
23galactosemia10.0TF
24friedreich ataxia10.0TFRC, SLC25A28
25congenital porphyria10.0ALAD, FECH
26hereditary coproporphyria10.0ALAD, FECH
27acute porphyria10.0ALAD, FECH
28polycythemia10.0TFRC, HBB
29variegate porphyria10.0FECH, ALAD
30erythropoietic protoporphyria10.0FECH, ALAD, ALAS2
31hydrops fetalis10.0HBB
32sideroblastic anemia10.0ALAS2, TFRC
33acute intermittent porphyria10.0ALAD, FECH
34tuberculosis10.0HBB
35macrocytic anemia10.0ALAS2, TF
36siderosis10.0TF, TFRC
37malaria10.0HBB, ALAD, TFRC
38microcytic anemia10.0ALAS2, TFRC, TF
39hemoglobinopathy10.0TF, HBB, TFRC
40iron metabolism disease10.0HBB, TFRC, TF
41hemolytic anemia10.0TFRC, TF, HBB
42porphyria10.0FECH, TF, ALAD, ALAS2
43porphyria cutanea tarda10.0TF, FECH, TFRC, ALAD
44sickle cell disease10.0TF, HBB, ALAS2, TFRC
45proliferative vitreoretinopathy10.0TF, TFRC
46acute erythroid leukemia10.0FECH, ALAS2, HBB, TF, TFRC

Graphical network of the top 20 diseases related to Hypochromic Anemia:



Diseases related to hypochromic anemia

Clinical Features for Hypochromic Anemia

Drugs & Therapeutics for Hypochromic Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hypochromic Anemia

Drug clinical trials:

Search ClinicalTrials for Hypochromic Anemia

Search NIH Clinical Center for Hypochromic Anemia

Search CenterWatch for Hypochromic Anemia

Genetic Tests for Hypochromic Anemia

Anatomical Context for Hypochromic Anemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypochromic Anemia:

33
Liver, Brain, Bone marrow, Whole blood, Myeloid, Fetal brain, Fetal liver

Animal Models for Hypochromic Anemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypochromic Anemia

Sources:
51PubMed
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Articles related to Hypochromic Anemia:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
I+-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with I^-thalassemia, iron deficiency anemia. (22475300)
2012
2
The diagnostic accuracy of the percentage of hypochromic red blood cells (%HYPOm) and cellular hemoglobin in reticulocytes (CHr) in differentiating iron deficiency anemia and anemia of chronic diseases. (21689644)
2011
3
Microcytic hypochromic anemia patients with thalassemia: genotyping approach. (19359777)
2009
4
Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia. (19205647)
2009
5
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. (19579082)
2009
6
A differential diagnosis of microcytic hypochromic anemia for high-risk patients. (19570166)
2009
7
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. (18552213)
2008
8
Innovative parameters RET-Y, sTfR, and sTfR-F index in patients with microcytic, hypochromic anemia--their special value for hemoglobinopathies. (17573284)
2007
9
Hypochromic microcytic anemia as a clinical presentation of celiac disease. (16812948)
2006
10
A 16-year-old girl with hypochromic microcytic anemia. (16253038)
2005
11
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. (15994289)
2005
12
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. (15121718)
2004
13
alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia. (14555321)
2003
14
A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma. (14513774)
2003
15
Low plasma cholesterol: a correlate of nondiagnosed celiac disease in adults with hypochromic anemia. (10406254)
1999
16
Effects of high-dose vitamin B6 therapy on microcytic and hypochromic anemia in hemodialysis patients. (8255009)
1993
17
Contribution of education to cost-effective care of microcytic, hypochromic anemia. (6427387)
1984
18
Growth and maturation arrest, hypochromic anemia and hyperglobulinemia associated with a brain tumor. (7233896)
1980
19
An investigation on the psychopathology of pica and hypochromic anemia. (4770545)
1973
20
Unusual type of hypochromic anemia complicating Billroth II type gastrectomy. (5554840)
1971
21
Vitamin B12, serum folate, and hypochromic anemia. (5781482)
1969
22
Gamma-A deficiency and hypochromic anemia due to defective iron mobilization. (6020748)
1967
23
Severe hypochromic anemia in a newborn, due to fetal-maternal transfusion. (5949644)
1966
24
ROENTGENOGRAPHIC FINDINGS IN TWO PATIENTS WITH HYPOCHROMIC ANEMIA. (14146008)
1964
25
An iron, pyridoxine and ascorbic acid combination in the treatment of hypochromic anemia. (14021886)
1963
26
Hypochromic anemia and hemochromatosis. Response to combined testosterone, pyridoxine, and liver extract therapy. (13896898)
1962
27
Pyridoxine-responsive hypochromic anemia. A report of two case. (13720319)
1961
28
Hemoglobin synthesis with iron choline citrate in hypochromic anemia of pregnancy. (13722597)
1960
29
Hypochromic anemia of pregnancy: a new diagnostic aid and oral therapy with ferroglycine sulfate complex. (13667740)
1959
30
The development of the use of iron in hypochromic anemia. (13649708)
1959
31
Idiopathic hypochromic anemia in males. (13849052)
1959
32
The intestinal absorption of ferric ion administered orally; therapeutic effect in infants and children with hypochromic anemia. (13628042)
1959
33
Hypochromic microcytic anemia of infancy; iron depletion as a factor. (13378924)
1956
34
Maternal factors in hypochromic anemia of infancy. (13366657)
1956
35
Hypochromic anemia without iron deficiency; final word]. (14349803)
1955
36
IDIOPATHIC hypochromic anemia. (14371211)
1955
37
Supplementary notes on anemia in pregnant women; on the origin and treatment of microcytic hypochromic anemia during toxemias in pregnancy. (13252298)
1955
38
Pathogenesis of hypochromic anemia. (13097554)
1953
39
Use of ferric and ferrous iron in the prevention of hypochromic anemia in infants. (13103769)
1953
40
The intravenous use of high molecular ferric carbohydrate compound in the treatment of hypochromic anemia. (14904518)
1952
41
Hypochromic anemia in the aged. (14890306)
1951
42
Iron therapy in hypochromic anemia. (14807665)
1951
43
Intravenously administered saccharated iron oxide in the treatment of hypochromic anemia; therapeutic results, potential dangers and indications. (14774236)
1950
44
Familial hypochromic anemia associated with postsplenectomy erythrocytic inclusion bodies. (18133599)
1949
45
Hypochromic anemia. (18888343)
1948
46
Evaluation of molybdenized ferrous sulfate in the treatment of hypochromic anemia of pregnancy. (18884785)
1948
47
Hypochromic anemia; treatment with molybdenum-iron complex. (20989994)
1946
48
Observations on the effect of massive doses of iron given intravenously to patients with hypochromic anemia. (21015976)
1946
49
Hypochromic anemia with epithelial changes and acne rosacea. (21005788)
1945
50
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA. (16694502)
1937

Genetic Variations for Hypochromic Anemia

Expression for genes affiliated with Hypochromic Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypochromic Anemia

Search GEO for disease gene expression data for Hypochromic Anemia.

Pathways for genes affiliated with Hypochromic Anemia

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome
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Compounds for genes affiliated with Hypochromic Anemia

Sources:
11DrugBank, 45Novoseek, 24HMDB, 29IUPHAR
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Compounds related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
14-[(5-methoxy-2-methylphenoxy)methyl]pyridine1110.3HBA1, HBB
22-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID1110.3HBA1, HBB
3SEBACIC ACID1110.3HBA1, HBB
41,3,5-BENZENETRICARBOXYLIC ACID1110.3HBA1, HBB
52,6-DICARBOXYNAPHTHALENE1110.3HBB, HBA1
64-Carboxycinnamic Acid1110.3HBA1, HBB
72-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID1110.3HBA1, HBB
82-[(2-methoxy-5-methylphenoxy)methyl]pyridine1110.3HBA1, HBB
9ppix4510.2FECH, TFRC
10protoporphyrinogen4510.2FECH, ALAD
11aluminium citrate4510.2TFRC, TF
12ethylenediaminetetraacetic acid4510.2FECH, ALAD
13gallium4510.2TFRC, TF
14deferiprone4510.2TF, TFRC
15porphyrin4510.2ALAD, FECH
16aluminium45 1111.2TF, TFRC
17apotransferrin4510.1TFRC, TF
18bismuth45 2411.1TFRC, TF
19ferric ammonium citrate4510.1TFRC, TF
20formyl-coa45 2411.1FECH, ALAD, ALAS2
21benzidine4510.1HBB, TFRC
22fe3+4510.0TFRC, TF, FECH
23haem4510.0FECH, ALAS2
24fe2+459.9FECH, TF, TFRC
25deferoxamine45 1110.9TFRC, TF, FECH
26tbps45 2910.9TF, TFRC
27vitamin b12459.9ALAD, TFRC, TF
28nh4cl459.8TFRC, TF
29copper45 2410.7FECH, TF, ALAD
30porphobilinogen45 11 2411.7ALAD, HBB, TFRC, FECH
31zinc protoporphyrin459.7FECH, TF, TFRC, ALAD
32iron dextran45 1110.7TF, TFRC, HBB, HBA1
33iron-sulfur459.7ALAS2, FECH
34succinylacetone459.6ALAD, HBB, TFRC, TF
35glutamine459.5TF, TFRC, HBB, ALAS2
365-aminolevulinic acid45 2410.5ALAS2, ALAD, HBB, TFRC, FECH
37dmso459.5HBB, TFRC, FECH
38protoporphyrin ix45 11 2411.5FECH, TF, TFRC, ALAD, ALAS2
39lactate459.4ALAD, HBB, TFRC, TF
40aspartate459.4ALAS2, HBB, TFRC, TF
41alanine459.3FECH, TF, TFRC, HBB, ALAS2
42heme29 11 2410.3ALAS2, FECH, TF, HBB, HBA1, SLC25A37
43iron45 249.0FECH, TF, TFRC, HBB, HBA1, SLC25A37

GO Terms for genes affiliated with Hypochromic Anemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057438.8ALAS2, SLC25A28, SLC25A37, FECH
2perinuclear region of cytoplasmGO:0484718.8TFRC, TF, NDFIP2, NDFIP1

Biological processes related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:0067789.9ALAS2, ALAD, FECH
2heme biosynthetic processGO:0067839.9FECH, ALAD, ALAS2
3protoporphyrinogen IX biosynthetic processGO:0067829.9ALAD, ALAS2
4transferrin transportGO:0335729.8TFRC, TF
5negative regulation of protein transportGO:0512249.5NDFIP2, NDFIP1
6iron ion homeostasisGO:0550729.5SLC25A28, SLC25A37, FECH
7negative regulation of transporter activityGO:0324109.4NDFIP2, NDFIP1
8erythrocyte differentiationGO:0302189.3EXOC6, FECH, ALAS2
9cellular iron ion homeostasisGO:0068799.2ALAS2, TFRC, TF, NDFIP1
10small molecule metabolic processGO:0442818.2FECH, HBB, SLC25A37, SLC25A28, ALAD, ALAS2

Molecular functions related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1WW domain bindingGO:0506999.4NDFIP2, NDFIP1

Products for genes affiliated with Hypochromic Anemia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hypochromic Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet