MCID: HYP054
MIFTS: 46

Hypochromic Anemia malady

Immune diseases, Blood diseases categories

Summaries for Hypochromic Anemia

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Wikipedia:64 Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes)... more...

MalaCards based summary: Hypochromic Anemia, also known as anemia hypochromic, is related to alpha thalassemia and sideroblastic anemia. An important gene associated with Hypochromic Anemia is ALAS2 (aminolevulinate, delta-, synthase 2), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and O2/CO2 exchange in erythrocytes. The compounds protoporphyrinogen and ethylenediaminetetraacetic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and brain, and related mouse phenotypes are reproductive system and liver/biliary system.

Aliases & Classifications for Hypochromic Anemia

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 26ICD10
See all sources

Hypochromic Anemia, Aliases & Descriptions:

Name: Hypochromic Anemia 9 11
Anemia Hypochromic 9 44
 
Hereditary Sideroblastic Anemia 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:11759
MeSH34 D000747
SNOMED-CT56 44452003
NCIt39 C34380
ICD1026 D64.0

Related Diseases for Hypochromic Anemia

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Diseases related to Hypochromic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1alpha thalassemia30.8HBA1, HBB
2sideroblastic anemia30.6TFRC, ALAS2
3hemochromatosis30.5TF, TFRC
4microcytic anemia30.4ALAS2, TFRC, TF
5hypochromic microcytic anemia30.3HBB, TF
6x-linked sideroblastic anemia30.3SLC25A28, NDFIP2, NCKAP1L
7hemoglobinopathy30.1TF, TFRC, HBB
8beta thalassemia30.1TF, TFRC, HBB
9thalassemia10.4
10congenital erythropoietic porphyria10.3ALAD, FECH
11hereditary coproporphyria10.3FECH, ALAD
12acute porphyria10.3ALAD, FECH
13hemosiderosis10.3
14iron-refractory iron deficiency anemia10.3
15acute intermittent porphyria10.3FECH, ALAD
16variegate porphyria10.3ALAD, FECH
17refractory anemia10.3ALAS2, TFRC
18erythropoietic protoporphyria10.2FECH, ALAD, ALAS2
19sickle cell anemia10.2HBB, HBA1
20friedreich ataxia10.2SLC25A28, TFRC
21polycythemia10.2HBB, TFRC
22acne10.1
23celiac disease10.1
24leukemia10.1
25renal cell carcinoma10.1
26myoma10.1
27thrombocytosis10.1
28rosacea10.1
29benjamin syndrome10.1
30hypochromic microcytic anemia with iron overload 210.1
31macrocytic anemia10.1TF, ALAS2
32siderosis10.1TFRC, TF
33restless legs syndrome10.1TF, TFRC
34malaria10.0ALAD, HBB, TFRC
35proliferative vitreoretinopathy10.0TF, TFRC
36iron deficiency anemia9.9FECH, TFRC, TF
37diphtheria9.9TFRC, TF
38uremia9.9ALAD, TF
39iron metabolism disease9.9HBB, TFRC, TF
40hemolytic anemia9.9TF, TFRC, HBB
41porphyria9.9ALAS2, ALAD, FECH, TF
42porphyria cutanea tarda9.8ALAD, FECH, TFRC, TF
43galactosemia9.8TF, FECH, ALAD
44non-suppurative otitis media9.8TFRC, TF
45sickle cell disease9.8ALAS2, HBB, TFRC, TF
46acute erythroid leukemia9.6TF, TFRC, HBB, FECH, ALAS2
47deficiency anemia9.3TF, TFRC, HBA1, HBB, FECH, ALAD

Graphical network of the top 20 diseases related to Hypochromic Anemia:



Diseases related to hypochromic anemia

Symptoms for Hypochromic Anemia

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Drugs & Therapeutics for Hypochromic Anemia

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Drug clinical trials:

Search ClinicalTrials for Hypochromic Anemia

Search NIH Clinical Center for Hypochromic Anemia

Genetic Tests for Hypochromic Anemia

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Anatomical Context for Hypochromic Anemia

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MalaCards organs/tissues related to Hypochromic Anemia:

32
Liver, Whole blood, Brain, Myeloid

Animal Models for Hypochromic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Hypochromic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.1NCKAP1L, STEAP3, FECH, HBB, HBA1
2MP:00053707.9TFRC, HBB, FECH, STEAP3, NCKAP1L
3MP:00053977.3NCKAP1L, ALAS2, STEAP3, FECH, HBB, TFRC
4MP:00053767.0TF, TFRC, HBB, FECH, STEAP3, ALAS2

Publications for Hypochromic Anemia

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Articles related to Hypochromic Anemia:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Microcytic hypochromic anemia: should high performance liquid chromatography be used routinely for screening anemic and antenatal patients? (24056645)
2013
2
A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene. (22031863)
2011
3
Molecular spectrum of alpha-thalassemia mutations in microcytic hypochromic anemia patients from Saudi Arabia. (19371220)
2009
4
Microcytic hypochromic anemia patients with thalassemia: genotyping approach. (19359777)
2009
5
Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia. (19205647)
2009
6
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. (18552213)
2008
7
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. (17003376)
2007
8
A "hidden treasure" causing microcytic hypochromic anemia. (16377336)
2006
9
A mutation in the gene for delta-aminolevulinic acid dehydratase (ALAD) causes hypochromic anemia in the medaka, Oryzias latipes. (15210182)
2004
10
alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia. (14555321)
2003
11
A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma. (14513774)
2003
12
Microcytic hypochromic anemia in idiopathic pulmonary hemosiderosis: a diagnostic pitfall. (7883371)
1994
13
Effects of high-dose vitamin B6 therapy on microcytic and hypochromic anemia in hemodialysis patients. (8255009)
1993
14
Fatal cerebrovascular thrombosis in a young woman: an unusual complication associated with hypochromic anemia and thrombocytosis following surgery. (3266301)
1988
15
Hemoglobin deficit: an inherited hypochromic anemia in the mouse. (3960859)
1986
16
Contribution of education to cost-effective care of microcytic, hypochromic anemia. (6427387)
1984
17
Hypocupremia-related hypochromic anemia during D-penicillamine treatment. (7066031)
1982
18
Iron and hypochromic anemia. (788038)
1975
19
Vitamin B12, serum folate, and hypochromic anemia. (5781482)
1969
20
The iron content of gastric juice: in relation to the cause of idiopathic hypochromic anemia. (4230849)
1967
21
Hypochromic anemia with increased iron stores. (6046807)
1967
22
Severe hypochromic anemia in a newborn, due to fetal-maternal transfusion. (5949644)
1966
23
Intriguing types of hypochromic anemia. (14024424)
1963
24
XANTHOFIBROMA OF THE STOMACH. REPORT OF A CASE WITH SEVERE SECONDARY HYPOCHROMIC ANEMIA. (14087280)
1963
25
Hypochromic anemia and hemochromatosis--response to combined testosterone, pyridoxine, and liver extract therapy. (13896897)
1961
26
Hemoglobin synthesis with iron choline citrate in hypochromic anemia of pregnancy. (13722597)
1960
27
Comparison of intravenous saccharated iron oxide and whole blood in treatment of hypochromic anemia of pregnancy. (13796713)
1960
28
Hypochromic anemia of pregnancy: a new diagnostic aid and oral therapy with ferroglycine sulfate complex. (13667740)
1959
29
The development of the use of iron in hypochromic anemia. (13649708)
1959
30
Idiopathic hypochromic anemia in males. (13849052)
1959
31
Nutritional assessment of infants with hypochromic anemia. (13845872)
1959
32
The intestinal absorption of ferric ion administered orally; therapeutic effect in infants and children with hypochromic anemia. (13628042)
1959
33
Maternal factors in hypochromic anemia of infancy. (13366657)
1956
34
Hypochromic anemia without iron deficiency; final word]. (14349803)
1955
35
A new approach to the treatment of hypochromic anemia. (13012595)
1953
36
Pathogenesis of hypochromic anemia. (13097554)
1953
37
Use of ferric and ferrous iron in the prevention of hypochromic anemia in infants. (13103769)
1953
38
The intravenous use of high molecular ferric carbohydrate compound in the treatment of hypochromic anemia. (14904518)
1952
39
Hypochromic anemia in the aged. (14890306)
1951
40
Intravenous iron therapy in parasitic hypochromic anemia. (14819801)
1951
41
Iron therapy in hypochromic anemia. (14807665)
1951
42
Treatment of iron deficiency (hypochromic anemia). (18909741)
1948
43
Use of colloidal iron hydroxide for the treatment of hypochromic anemia; notes on incidence of gastrointestinal irritation with iron therapy. (20263162)
1947
44
Is the broad tape-worm the casual agent of hypochromic anemia? (18919070)
1947
45
Hypochromic anemia; treatment with molybdenum-iron complex. (20989994)
1946
46
Observations on the effect of massive doses of iron given intravenously to patients with hypochromic anemia. (21021594)
1945
47
Lymphatic leukemia with a myeloid blood picture complicated by a severe microcytic hypochromic anemia in a dog. (21009464)
1945
48
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA. (16694502)
1937
49
STUDIES ON HYPOCHROMIC ANEMIA IN DOGS. I. THE EVALUATION OF A STANDARD BREAD DIET AND OF A MEAT DIET ON FORMATION OF HEMOGLOBIN BEFORE AND AFTER GASTRECTOMY. (16694395)
1936
50
QUANTITATIVE ASPECTS OF IRON DEFICIENCY IN HYPOCHROMIC ANEMIA: (The Parenteral Administration of Iron). (16694103)
1932

Variations for Hypochromic Anemia

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Expression for genes affiliated with Hypochromic Anemia

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Expression patterns in normal tissues for genes affiliated with Hypochromic Anemia

Search GEO for disease gene expression data for Hypochromic Anemia.

Pathways for genes affiliated with Hypochromic Anemia

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Compounds for genes affiliated with Hypochromic Anemia

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Sources:
44Novoseek, 12DrugBank, 25HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1protoporphyrinogen4410.2ALAD, FECH
2ethylenediaminetetraacetic acid4410.2FECH, ALAD
3porphyrin4410.2ALAD, FECH
4ppix4410.1FECH, TFRC
5haem4410.1FECH, ALAS2
6iron-sulfur4410.1ALAS2, FECH
7aluminium citrate4410.1TFRC, TF
8gallium4410.0TFRC, TF
9deferiprone4410.0TFRC, TF
10aluminium44 1211.0TFRC, TF
11bismuth44 2511.0TF, TFRC
12apotransferrin4410.0TF, TFRC
13benzidine4410.0HBB, TFRC
14vitamin b64410.0ALAS2, FECH
15ferric ammonium citrate4410.0TFRC, TF
16formyl-coa44 2511.0FECH, ALAD, ALAS2
17tbps44 2910.9TF, TFRC
18s-nitroso-n-acetylpenicillamine449.9TFRC, FECH
19nh4cl449.9TF, TFRC
20bafilomycin a144 60 1211.8TFRC, TF
21vitamin b12449.7TF, TFRC, ALAD
22fe3+449.7FECH, TFRC, TF
23leupeptin449.7TFRC, TF
24fe2+449.7TF, TFRC, FECH
25deferoxamine44 1210.7FECH, TFRC, TF
26dmso449.7TFRC, HBB, FECH
27betacarotene449.6TFRC, TF
28butyrate449.6ALAS2, HBB, TFRC
29ascorbic acid44 2510.6ALAD, TFRC, TF
30acetaldehyde29 44 2511.5HBB, TF
31porphobilinogen44 25 1211.5ALAD, FECH, HBB, TFRC
32zinc protoporphyrin449.4TF, TFRC, FECH, ALAD
33selenium44 2510.4ALAD, TF
34zinc44 2510.4ALAS2, ALAD, FECH, HBB
35succinylacetone449.4ALAD, HBB, TFRC, TF
36iron dextran44 1210.3TF, TFRC, HBA1, HBB
37glutamine449.3ALAS2, HBB, TFRC, TF
38aspartate449.3ALAS2, HBB, TFRC, TF
39lactate449.3TF, TFRC, HBB, ALAD
40copper44 2510.3ALAD, STEAP3, FECH, TF
415-aminolevulinic acid44 2510.2ALAS2, ALAD, FECH, HBB, TFRC
42protoporphyrin ix44 25 1211.2TF, TFRC, FECH, ALAD, ALAS2
43oxygen44 2510.1HBA1, HBB, FECH, ALAS2
44alanine449.0TF, TFRC, HBB, FECH, ALAS2
45heme29 25 129.7TF, HBA1, HBB, FECH, STEAP3, ALAD
46iron44 258.3SLC25A28, TF, ALAS2, ALAD, STEAP3, FECH

GO Terms for genes affiliated with Hypochromic Anemia

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Cellular components related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coated pitGO:0059059.6TFRC, TF
2blood microparticleGO:0725629.1HBB, TFRC, TF
3mitochondrial inner membraneGO:0057438.9SLC25A28, ALAS2, FECH

Biological processes related to Hypochromic Anemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protoporphyrinogen IX biosynthetic processGO:0067829.9ALAS2, ALAD
2erythrocyte differentiationGO:0302189.8ALAS2, FECH
3porphyrin-containing compound metabolic processGO:0067789.7FECH, ALAD, ALAS2
4heme biosynthetic processGO:0067839.7ALAS2, ALAD, FECH
5iron ion homeostasisGO:0550729.2SLC25A28, FECH
6transferrin transportGO:0335729.2TF, TFRC, STEAP3
7cellular iron ion homeostasisGO:0068799.0ALAS2, STEAP3, TFRC, TF
8small molecule metabolic processGO:0442818.4HBB, FECH, ALAD, ALAS2, SLC25A28

Molecular functions related to Hypochromic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.7NDFIP2, NCKAP1L, ALAS2, STEAP3, FECH, HBB

Products for genes affiliated with Hypochromic Anemia

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Sources for Hypochromic Anemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet