Hypodontia malady

Wikipedia: In dentistry, hypodontia is the condition at which the patient has missing teeth as a result of their...⁴⁴ more...

MalaCards: Hypodontia is related to tooth agenesis and hypohidrotic ectodermal dysplasia. An important gene associated with Hypodontia is MSX1 (msh homeobox 1), and among its related pathways are Development FGF-family signaling and PTEN Pathway. The compounds pd 161570 and su 5402 have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and hearing/vestibular/ear.

hypodontia 7 32

Diseases related to hypodontia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 139)

id	Related Disease	Score	Top Affiliating Genes
1	tooth agenesis	29.5	PAX9, MSX1
2	hypohidrotic ectodermal dysplasia	28.9	EDAR, EDA
3	oligodontia	27.8	EDA, LTBP3, FAM20A, MSX1, PAX9, POLR3A
4	hypotrichosis	27.4	EDA, WNT10A, DSPP, EDAR
5	fgfr-related craniosynostosis syndromes	27.1	FGFR3, FGFR2
6	strabismus	26.7	DSPP, FGFR2, FGFR3
7	ectodermal dysplasia	26.5	IRF6, MSX1, FGFR2, FGFR3, TP63, EDA
8	craniosynostosis, syndromic	26.4	FGFR2, RHBDF1, FGFR3, FGF10
9	craniosynostosis	26.0	RHBDF1, TGFB3, FGFR2, FGFR3, FGF10
10	twinning	25.1	FGFR3, FGFR2, IRF6, PAX9, TGFB1, EDAR
11	cleft palate	22.4	MSX1, MMP9, IRF6, FGF10, FGFR2, TP63
12	cleft lip	22.1	PAX9, TGFB3, TGFB1, MSX1, MMP9, IRF6
13	taurodontism	13.6	EDA, DSPP
14	dentin dysplasia	13.4	DSPP, MSX1, PAX9
15	tricho-dento-osseous syndrome	13.2	DSPP, TP63
16	amelia cleft lip palate hydrocephalus iris coloboma	13.1	TGFB3, TP63, IRF6
17	birth defects	13.1	MSX1, IRF6, TP63
18	dental caries	13.0	DSPP, FGF10, IRF6
19	wolf-hirschhorn syndrome	13.0	MSX1, FGFR3, NSD1
20	hypohidrosis	13.0	TP63, EDA, EDAR
21	thanatophoric dysplasia	12.9	FGFR2, FGFR3
22	crouzonodermoskeletal syndrome	12.9	FGFR3, FGFR2
23	clear cell acanthoma	12.9	FGFR2, FGF10
24	orofacial cleft	12.9	TP63, TGFB3, MSX1, IRF6
25	osteoglophonic dysplasia	12.9	FGFR2, FGFR3
26	jackson-weiss syndrome	12.9	FGFR3, FGFR2
27	beare-stevenson cutis gyrata syndrome	12.9	FGFR3, FGFR2
28	muenke syndrome	12.9	FGFR2, FGFR3
29	plagiocephaly	12.9	FGFR3, FGFR2
30	amelogenesis imperfecta	12.8	FAM20A, TP63, DSPP, MSX1
31	van der woude syndrome	12.8	TGFB3, IRF6
32	ureteral disease	12.8	TGFB1, EDA
33	hay-wells syndrome	12.8	FGFR2, TP63
34	keloids	12.8	TGFB3, TIMP2, TGFB1
35	hypochondroplasia	12.7	FGF3, FGFR2, FGFR3
36	cockayne syndrome	12.7	FGFR3, FGFR2
37	achondroplasia	12.7	FGFR2, FGFR3, FGF3
38	acrocephalosyndactylia	12.6	FGFR2, FGFR3, FGF10
39	cerebellar hypoplasia	12.6	DSPP, FGF10, FGFR2, PITX2
40	infectious mononucleosis	12.6	FGFR2, FGF10, FGFR3
41	ankylosis	12.6	TGFB1, DSPP, FGFR2
42	microcystic meningioma	12.6	TIMP2, MMP9
43	developmental disabilities	12.6	FGFR2, PITX2, FGFR3
44	fibromatosis	12.5	TGFB3, TIMP2, TGFB1, FAM20A
45	synostosis	12.5	FGF10, MSX1, FGFR3, FGFR2
46	diabetic foot ulcers	12.4	TGFB1, MMP9, TGFB3
47	ladd syndrome	12.4	FGF3, FGFR3, FGFR2, FGF10
48	crouzon syndrome	12.3	FGFR3, FGFR2
49	hydrocephalus	12.2	TGFB1, FGFR3, FGFR2, IRF6
50	syndactyly	12.1	FGF10, FGFR2, FGFR3, TP63

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to hypodontia:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.4	FAM20A, TP63, PITX2, EDA, MSX1, PAX9
2	hearing/vestibular/ear phenotype	MP:0005377	8.4	IRF6, FGF10, FGFR2, FGF3, FGFR3, MSX1
3	craniofacial phenotype	MP:0005382	7.8	DSPP, EDAR, EDA, LTBP3, PITX2, FAM20A
4	endocrine/exocrine gland phenotype	MP:0005379	7.7	TGFB1, EDAR, PITX2, TP63, FGFR2, FGF10
5	normal phenotype	MP:0002873	7.3	TP63, FGFR3, PAX9, FGFR2, FGF3, FGF10
6	embryogenesis phenotype	MP:0005380	7.3	TGFB3, PAX9, MSX1, FGF10, FGF3, FGFR2
7	muscle phenotype	MP:0005369	7.2	PAX9, TGFB1, TP63, FGF10, MSX1, MMP9
8	skeleton phenotype	MP:0005390	7.0	MMP9, FGF10, FGF3, TGFB3, EDA, LTBP3
9	renal/urinary system phenotype	MP:0005367	7.0	FGFR2, TGFB1, EDA, FAM20A, FGFR3, MMP9
10	cardiovascular system phenotype	MP:0005385	6.8	PITX2, FGF10, MSX1, MMP9, FGFR2, TGFB1
11	vision/eye phenotype	MP:0005391	6.7	FGFR2, FGF10, FGFR3, TP63, PITX2, LTBP3
12	reproductive system phenotype	MP:0005389	6.5	TGFB1, TP63, FGFR3, FGF10, MMP9, MSX1
13	integument phenotype	MP:0010771	6.4	MMP9, IRF6, FGF10, FGFR2, FGFR3, TP63
14	limbs/digits/tail phenotype	MP:0005371	6.4	PITX2, FGF10, FGFR3, EDA, TP63, TGFB3
15	immune system phenotype	MP:0005387	6.3	PAX9, MMP9, TIMP2, FGFR2, FGFR3, TGFB1
16	behavior/neurological phenotype	MP:0005386	6.2	TGFB1, TP63, FGFR2, TIMP2, FGF3, TGFB3
17	digestive/alimentary phenotype	MP:0005381	6.1	FGFR2, FGF10, IRF6, MMP9, MSX1, PAX9
18	nervous system phenotype	MP:0003631	5.9	FGFR2, MSX1, PITX2, FGF3, FGFR3, TIMP2
19	growth/size phenotype	MP:0005378	5.6	FGFR3, EDA, PAX9, TGFB1, MSX1, MMP9
20	mortality/aging	MP:0010768	4.9	EDAR, FGF3, FGFR2, FGFR3, FAM20A, TP63

Articles related to hypodontia:

(show all 26)

id	Title	Authors	Year	Affiliating Genes
1	Clinical and functional data implicate the Arg(151)Se r variant of MSX1 in familial hypodontia. (21448236)	Kamamoto M.... Tokita Y.	2011	MSX1
2	Correlation between the phenotypes and genotypes of X -linked hypohidrotic ectodermal dysplasia and non-syndromic hypodontia caused b y ectodysplasin-A mutations. (21457804)	Zhang J.... Feng H.	2011	EDA
3	Genetic basis of non syndromic hypodontia: a DNA inve stigation performed on three couples of monozygotic twins about PAX9 mutation. (21434731)	Militi D.... Salpietro D.C.	2011	PAX9
4	A common founder mutation in the EDA-A1 gene in X-lin ked hypodontia. (20628232)	Kurban M.... Christiano A.M.	2010	EDA
5	A novel missense mutation in the ectodysplasin-A (EDA ) gene underlies X-linked recessive nonsyndromic hypodontia. (21091672)	Ayub M.... Ahmad W.	2010	EDA
6	Hypodontia in Beare-Stevenson syndrome: an example of dental anomalies in FGFR-related craniosynostosis syndromes. (19860525)	Tao Y.C.... Oberoi S.	2010	RHBDF1
7	Recurrent mutations in functionally-related EDA and E DAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohid rotic ectodermal dysplasia. (19551394)	Azeem Z.... Ahmad W.	2009	EDA, EDAR
8	Premolar hypodontia is a common feature in Sotos synd rome with a mutation in the NSD1 gene. (19876911)	Kotilainen J.... Nieminen P.	2009	NSD1
9	Studies of palatine rugae and interferon regulatory f actor 6 variations in a group of families with sporadic hypodontia. (20032603)	Murdoch A.M.... Vieira A.R.	2009	IRF6
10	Tooth dimensions in hypodontia with a known PAX9 muta tion. (18653171)	Brook A.H.... Smith R.N.	2009	PAX9
11	Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis. (18657636)	Han D.... Song S.	2008	PAX9, MSX1, EDA
12	A novel missense mutation in the EDA gene associated with X-linked recessive isolated hypodontia. (18688569)	Rasool M.... Baig S.M.	2008	EDA
13	Mutations in the EDA gene are responsible for X-linked hypohidrotic ectodermal dysplasia and hypodontia in Chinese kindreds. (18821982)	Fan H.... Bian Z.	2008	EDA
14	A novel Gln358Glu mutation in ectodysplasin A associated with X- linked dominant incisor hypodontia. (17256800)	Tarpey P.... Patel P.I.	2007	EDA
15	A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia. (16583127)	Tao R.... He L.	2006	EDA
16	Analysis of MMP-9 and TIMP-2 gene promoter polymorphisms in individuals with hypodontia. (16429190)	Peres R.C.... Line S.R.	2005	MMP9, TIMP2
17	Association between PAX-9 promoter polymorphisms and hypodontia in humans. (16137495)	Peres R.C.... Line S.R.	2005	PAX9
18	Absence of association between transforming growth factor-beta1 promoter polymorphisms and hypodontia. (15529502)	Peres R.C.... Line S.R.	2004	TGFB1
19	A novel MSX1 mutation in hypodontia. (15264286)	De Muynck S.... Carels C.	2004	MSX1
20	Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region. (12733956)	Slayton R.L.... Nishimura C.J.	2003	TGFB3, MSX1
21	Novel missense mutations and a 288-bp exonic insertion in PAX9 in families with autosomal dominant hypodontia. (12605438)	Das P.... Patel P.I.	2003	PAX9
22	Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia. (11941488)	Das P.... Patel P.I.	2002	PAX9
23	Absence of mutations in the homeodomain of the MSX1 gene in patients with hypodontia. (10861665)	Scarel R.M.... Line S.R.	2000	MSX1
24	A locus for autosomal recessive hypodontia with associated dental anomalies maps to chromosome 16q12.1. (9529357)	Ahmad W.... Christiano A.M.	1998	HYD2
25	Gene defect in hypodontia: exclusion of EGF, EGFR, and FGF-3 as candidate genes. (8831628)	Arte S.... Peltonen L.	1996	FGF3
26	Palmoplantar epidermal atrophy with hypokeratosis, d ys- and hypotrichosis, hypodontia, enamel and dentin hypoplasia, isolated cleft palate with cleft uvula, strabismus cryptorchism and other anomalies--an undes cribed ecto-mesodermal dysplasia? (1677642)	Salamon T.... Dojcinov D.	1991	DSPP

Genes related to hypodontia according to GeneCards:

(show all 24)

id	Symbol	Description	Score	GeneCards Section Context
1	MSX1	msh homeobox 1	11.1	Publications, Summaries
2	HYD2	hypodontia, autosomal recessive (2)	11.0	Publications, Aliases & Descriptions
3	PAX9	paired box 9	11.0	Publications
4	EDA	ectodysplasin A	11.0	Publications
5	IRF6	interferon regulatory factor 6	11.0	Publications
6	PITX2	paired-like homeodomain 2	11.0
7	TGFB3	transforming growth factor, beta 3	11.0	Publications
8	DSPP	dentin sialophosphoprotein	11.0	Publications
9	WNT10A	wingless-type MMTV integration site family, member 10A	11.0
10	RHBDF1	rhomboid 5 homolog 1 (Drosophila)	11.0	Publications
11	RBM28	RNA binding motif protein 28	11.0
12	FGF3	fibroblast growth factor 3	11.0	Publications
13	LTBP3	latent transforming growth factor beta binding protein 3	11.0
14	POLR3A	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	11.0
15	FAM20A	family with sequence similarity 20, member A	11.0
16	FGF10	fibroblast growth factor 10	11.0
17	EDAR	ectodysplasin A receptor	11.0	Publications
18	NSD1	nuclear receptor binding SET domain protein 1	11.0	Publications
19	TP63	tumor protein p63	11.0
20	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
21	FGFR3	fibroblast growth factor receptor 3	11.0
22	FGFR2	fibroblast growth factor receptor 2	11.0
23	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
24	TGFB1	transforming growth factor, beta 1	11.0	Publications

Pathways related to hypodontia according to GeneDecks:

(show top 50)    (show all 68)

id	Pathway	Score	Top Affiliating Genes
1	Development FGF-family signaling10	9.8	FGFR2, FGF10
2	PTEN Pathway36	9.1	FGF10, FGFR2, FGFR3, LTBP3
3	JNK Pathway36	8.8	TGFB1, LTBP3, FGFR3, FGFR2
4	Paxillin Interactions36	8.5	TIMP2, FGF10, FGFR3, FGFR2, TGFB3, LTBP3
5	Glioma Invasiveness36	8.2	TGFB3, MMP9, FGF10, LTBP3, TIMP2, TGFB1
6	Apoptotic Pathways in Synovial Fibroblasts36	8.0	FGFR2, FGFR3, LTBP3, TGFB1, TGFB3, FGF10
7	p53 Mediated Apoptosis36	8.0	LTBP3, TIMP2, FGFR2, FGF10, TGFB1, TGFB3
8	Telomerase Components in Cell Signaling36	8.0	LTBP3, FGF10, FGFR2, TIMP2, TGFB1, TGFB3
9	Mitochondrial Apoptosis36	8.0	TIMP2, FGF10, TGFB1, TGFB3, LTBP3, FGFR2
10	NF-KappaB (p50-p65) Pathway36	8.0	LTBP3, TIMP2, FGF10, FGFR2, TGFB1, TGFB3
11	DHA Signaling36	8.0	TGFB3, TIMP2, LTBP3, FGFR3, FGFR2, TGFB1
12	NF-KappaB Family Pathway36	8.0	FGFR2, FGFR3, LTBP3, TGFB1, TIMP2, FGF10
13	ERK5 Signaling36	8.0	FGF10, TGFB3, FGFR3, LTBP3, FGFR2, TGFB1
14	Cellular Apoptosis Pathway36	8.0	TIMP2, TGFB3, TGFB1, LTBP3, FGF10, FGFR2
15	PPAR Pathway36	8.0	FGF10, FGFR2, FGFR3, LTBP3, TIMP2, TGFB1
16	eIF2 Pathway36	8.0	TIMP2, TGFB1, FGFR3, FGF10, FGFR2, LTBP3
17	Nuclear Receptor Activation by Vitamin-A36	8.0	TGFB1, LTBP3, FGFR3, FGF10, TGFB3, FGFR2
18	Rac1 Pathway36	8.0	TGFB3, TIMP2, LTBP3, FGFR3, TGFB1, FGF10
19	Actin-Based Motility by Rho Family GTPases36	8.0	TGFB1, TIMP2, FGFR2, FGF10, LTBP3, TGFB3
20	p70S6K Signaling36	8.0	LTBP3, TIMP2, TGFB1, FGFR2, FGFR3, TGFB3
21	IP3 Pathway36	8.0	TGFB1, TGFB3, TIMP2, FGFR3, FGF10, FGFR2
22	Activation of PKC through GPCR36	7.9	TIMP2, FGFR3, LTBP3, TGFB1, TGFB3, FGF10
23	Renin-Angiotensin Pathway36	7.9	FGFR2, TGFB1, FGFR3, LTBP3, TIMP2, TGFB3
24	14-3-3 Induced Intracellular Signaling36	7.9	TGFB3, TGFB1, TIMP2, LTBP3, FGFR3, FGFR2
25	Rap1 Pathway36	7.9	TIMP2, LTBP3, FGFR3, FGFR2, TGFB1, TGFB3
26	TGF-Beta Pathway36	7.9	TGFB1, FGFR2, FGFR3, LTBP3, FGF10, TGFB3
27	Ras Pathway36	7.9	TIMP2, TGFB1, FGF10, FGFR2, FGFR3, LTBP3
28	eNOS Signaling36	7.9	TGFB1, TGFB3, FGF10, TIMP2, LTBP3, FGFR3
29	CREB Pathway36	7.9	TGFB3, FGF10, FGFR2, FGFR3, LTBP3, TIMP2
30	NFAT in Immune Response36	7.9	FGFR2, FGF10, TGFB3, FGFR3, LTBP3, TIMP2
31	Estrogen Pathway36	7.9	FGFR3, TGFB1, TGFB3, FGF10, FGFR2, TIMP2
32	GPCR Pathway36	7.9	TGFB1, TIMP2, LTBP3, FGF10, TGFB3, FGFR2
33	PAK Pathway36	7.9	TGFB3, FGF10, FGFR3, LTBP3, TIMP2, TGFB1
34	MAPK Family Pathway36	7.8	FGFR3, LTBP3, TIMP2, TGFB1, TGFB3, FGFR2
35	JAK-STAT Pathway36	7.8	TGFB3, FGF10, TGFB1, FGFR2, TIMP2, LTBP3
36	Nanog in Mammalian ESC Pluripotency36	7.8	FGFR2, FGFR3, TIMP2, TGFB1, TGFB3, WNT10A
37	Tec Kinases Signaling36	7.8	FGFR3, TIMP2, TGFB1, LTBP3, FGFR2, FGF10
38	Angiogenesis3	7.8	TGFB3, TGFB1, TIMP2, FGFR3, FGFR2, MMP9
39	GSK3 Signaling36	7.8	TIMP2, LTBP3, FGFR2, FGF10, TGFB1, TGFB3
40	Breast Cancer Regulation by Stathmin136	7.8	TGFB3, TGFB1, FGF10, TIMP2, LTBP3, FGFR3
41	Activation of PKA through GPCR36	7.7	TGFB1, TGFB3, FGFR3, TIMP2, LTBP3, FGF10
42	MAPK signaling pathway20	7.7	TGFB1, TGFB3, FGFR3, FGFR2, FGF3, FGF10
43	Intracellular Calcium Signaling36	7.7	FGF10, FGFR3, LTBP3, TIMP2, TGFB1, TGFB3
44	Phospholipase-C Pathway36	7.7	TGFB3, FGF10, FGFR2, FGFR3, LTBP3, TGFB1
45	ILK Signaling36	7.6	FGF10, FGFR2, FGFR3, LTBP3, TIMP2, TGFB3
46	Antioxidant Action of Vitamin-C36	7.6	LTBP3, TIMP2, TGFB1, TGFB3, FGFR3, FGF10
47	MAPK Signaling36	7.6	FGFR2, TGFB3, TGFB1, TIMP2, LTBP3, FGF10
48	p38 Signaling36	7.5	FGFR2, FGF10, TGFB1, LTBP3, TIMP2, TGFB3
49	Pathways in cancer20	7.4	MMP9, TGFB3, FGF3, FGFR2, FGFR3, TGFB1
50	Pancreatic Adenocarcinoma36	7.2	FGFR2, MMP9, LTBP3, FGFR3, FGF10, TGFB3

Compounds related to hypodontia according to GeneDecks:

(show all 21)

id	Compound	Score	Top Affiliating Genes
1	pd 16157042	9.6	FGFR2, FGFR3
2	su 540242	9.6	FGFR2, FGFR3
3	su540232	9.6	FGFR2, FGFR3
4	su 666842	9.6	FGFR2, FGFR3
5	pd 17307432 42	10.5	FGFR3, FGFR2
6	methyl selenol32	9.5	TIMP2, MMP9
7	palifermin32 9 9	11.4	FGFR3, FGFR2
8	paraffin32	9.3	TGFB1, TIMP2, FGFR3
9	tranilast32	9.0	TGFB1, MMP9
10	latanoprost32 9 9	10.9	TIMP2, MMP9
11	bromodeoxyuridine32	8.9	TGFB1, TP63, FGFR2, FGF10
12	hydroxyproline32 18	9.7	TIMP2, MMP9, TGFB1
13	erythromycin32 9 9	10.6	MMP9, FGFR2, TGFB1
14	lysine32	8.3	PITX2, FGFR2, TIMP2, TP63, FGFR3
15	glycosaminoglycan32	8.2	TGFB3, TIMP2, TGFB1, FGFR2, MMP9
16	ribonucleic acid32	8.2	MMP9, TGFB3, TGFB1, TIMP2, FGFR2
17	oligonucleotide32	8.0	FGF3, FGFR2, FGFR3, PITX2, TIMP2, TGFB1
18	estrogen32	7.4	FGFR2, MMP9, TP63, DSPP, TIMP2, TGFB3
19	retinoic acid32 42 18	9.3	TGFB3, MMP9, TIMP2, TP63, TGFB1, MSX1
20	tyrosine32	6.9	TIMP2, RHBDF1, MMP9, FGF10, FGFR2, FGFR3
21	vegf32	6.7	FGFR3, MMP9, FGF10, FGF3, FGFR2, TP63

Cellular components related to hypodontia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	8.7	WNT10A, TGFB1, DSPP, MMP9
2	cell surface	GO:009986	8.1	TGFB1, TIMP2, FGFR2, FGF10, TGFB3
3	extracellular region	GO:005576	6.6	MMP9, TGFB3, TGFB1, TIMP2, LTBP3, FAM20A

Biological processes related to hypodontia according to GeneDecks:

(show all 46)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of odontogenesis	GO:042481	10.5	MSX1, PAX9
2	salivary gland cavitation	GO:060662	10.3	EDAR, EDA
3	skin development	GO:043588	10.2	IRF6, EDA, WNT10A
4	embryonic camera-type eye development	GO:031076	10.2	PITX2, FGF10
5	ossification involved in bone remodeling	GO:043932	10.1	TGFB1, TGFB3
6	female genitalia morphogenesis	GO:048807	10.1	FGF10, TP63
7	negative regulation of macrophage cytokine production	GO:010936	10.1	TGFB1, TGFB3
8	frontal suture morphogenesis	GO:060364	10.0	TGFB1, TGFB3
9	endodermal digestive tract morphogenesis	GO:061031	10.0	FGFR2, PITX2
10	keratinocyte proliferation	GO:043616	10.0	FGF10, TP63, IRF6
11	branch elongation involved in salivary gland morphogenesis	GO:060667	9.9	FGFR2, FGF10
12	mammary gland bud formation	GO:060615	9.9	FGFR2, FGF10
13	mesenchymal cell differentiation involved in lung development	GO:060915	9.9	FGFR2, FGF10
14	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	GO:060595	9.9	FGFR2, FGF10
15	epidermis morphogenesis	GO:048730	9.9	WNT10A, FGFR2
16	lacrimal gland development	GO:032808	9.9	FGF10, FGFR2
17	cellular response to growth factor stimulus	GO:071363	9.9	PAX9, TGFB1, TGFB3
18	face morphogenesis	GO:060325	9.9	MSX1, PAX9, TGFB1, TGFB3
19	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	GO:060529	9.8	FGFR2, TP63
20	cellular response to cell-matrix adhesion	GO:071460	9.8	MMP9, DSPP
21	salivary gland morphogenesis	GO:007435	9.8	TGFB3, TGFB1
22	positive regulation of SMAD protein import into nucleus	GO:060391	9.8	TGFB3, TGFB1
23	embryonic digestive tract morphogenesis	GO:048557	9.7	PITX2, FGF10, FGFR2
24	otic vesicle formation	GO:030916	9.7	FGF10, FGF3, FGFR2
25	epithelial cell proliferation involved in salivary gland morphogenesis	GO:060664	9.7	FGF10, FGFR2
26	SMAD protein import into nucleus	GO:007184	9.7	TGFB3, TGFB1
27	positive regulation of canonical Wnt receptor signaling pathway	GO:090263	9.6	FGF10, FGFR2, EDA
28	positive regulation of keratinocyte migration	GO:051549	9.6	FGF10, MMP9
29	bone morphogenesis	GO:060349	9.6	MSX1, FGFR2, FGFR3
30	digestive tract development	GO:048565	9.5	TGFB1, TGFB3, FGFR2
31	positive regulation of phospholipase activity	GO:010518	9.5	FGFR2, FGFR3
32	odontogenesis	GO:042476	9.5	WNT10A, TGFB3, PITX2, PAX9, FGFR2
33	odontogenesis of dentin-containing tooth	GO:042475	9.5	EDAR, FGF10, TP63, EDA, MSX1
34	response to laminar fluid shear stress	GO:034616	9.5	TGFB3, TGFB1
35	in utero embryonic development	GO:001701	9.4	TGFB3, PITX2, FGFR2, MSX1
36	hair follicle morphogenesis	GO:031069	9.3	FGFR2, FGF10, WNT10A, TP63
37	positive regulation of cell division	GO:051781	9.3	FGFR2, TGFB1, TGFB3, FGF3
38	positive regulation of epithelial cell proliferation	GO:050679	9.2	FGFR2, FGF10, TGFB1
39	cell growth	GO:016049	9.2	TGFB3, TGFB1, MMP9
40	fibroblast growth factor receptor signaling pathway	GO:008543	9.1	FGFR2, FGF10, FGF3, FGFR3
41	insulin receptor signaling pathway	GO:008286	9.1	FGF10, FGFR3, FGF3, FGFR2
42	positive regulation of MAPK cascade	GO:043410	9.0	FGF10, FGFR2, FGFR3
43	skeletal system development	GO:001501	8.9	FGFR3, MMP9, TP63, DSPP
44	positive regulation of transcription, DNA-dependent	GO:045893	8.8	NSD1, TGFB3, TGFB1, TP63, IRF6, FGF10
45	negative regulation of cell proliferation	GO:008285	8.4	TGFB1, TIMP2, FGFR2, TGFB3, FGF10, IRF6
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	PITX2, PAX9, MSX1, FGF10, FGFR2, TGFB1

Molecular functions related to hypodontia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	type II transforming growth factor beta receptor binding	GO:005114	9.8	TGFB1, TGFB3
2	fibroblast growth factor-activated receptor activity	GO:005007	9.2	FGFR2, FGFR3
3	growth factor activity	GO:008083	8.9	FGF10, FGF3, TGFB1, TGFB3