Hypofibrinogenemia malady

Wikipedia: Fibrinolysis syndrome (also known as \"Defibrinating syndrome,\" and \"Hypofibrinogenemia\") is...⁴⁴ more...

MalaCards: Hypofibrinogenemia is related to von willebrand's disease and dysfibrinogenemia. An important gene associated with Hypofibrinogenemia is FGG (fibrinogen gamma chain), and among its related pathways are Cell adhesion_Integrin inside-out signaling and Metalloproteases in connective tissue degradation. The compounds clopidogrel and hepaplastin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are hematopoietic system and immune system.

hypofibrinogenemia 7 32 43

Diseases related to hypofibrinogenemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 353)

id	Related Disease	Score	Top Affiliating Genes
1	von willebrand's disease	28.0	VWF, F3, F2
2	dysfibrinogenemia	26.3	SERPINC1, FGA, FGB, FGG, F2, ALB
3	thrombophilia	25.1	VWF, SERPINC1, SERPINF2, SERPINE1, FGA, FGB
4	hepatitis	23.1	VWF, SERPINC1, SERPINF2, SERPINE1, FGA, FGB
5	thrombophilia, dysfibrinogenemic	13.6	FGB, FGG
6	afibrinogenemia	13.6	FGA, FGB
7	hereditary amyloidosis	13.5	FGA, APOA1
8	thrombosis	13.4	FGB, F2
9	factor xii deficiency	13.4	F3, F2
10	factor x deficiency	13.4	F3, F2
11	prothrombin deficiency	13.4	SERPINC1, F2
12	lymphoplasmacytic lymphoma	13.4	F3, F2
13	alpha-1-antichymotrypsin deficiency	13.4	SERPINC1, SERPINF2
14	hyperprothrombinemia	13.4	SERPINC1, F2
15	factor v deficiency	13.4	F3, F2
16	spinal cord infarction	13.4	SERPINC1, F2
17	sagittal sinus thrombosis	13.4	SERPINC1, F3
18	hantavirus pulmonary syndrome	13.3	F3, F2
19	central serous chorioretinopathy	13.3	SERPINE1, PLAT
20	intracranial embolism	13.3	SERPINC1, PLAT
21	ruptured abdominal aortic aneurysm	13.3	F3, F2
22	acute biphenotypic leukemia	13.3	F3, F2
23	vein disease	13.3	SERPINC1, F2
24	plasminogen activator inhibitor type 1 deficiency	13.3	SERPINE1, PLAT
25	plasminogen activator deficiency	13.3	SERPINE1, PLAT
26	vitamin k deficiency hemorrhagic disease	13.3	F3, F2
27	type 3 von willebrand disease	13.3	VWF, PLAT
28	sneddon syndrome	13.2	SERPINC1, F2
29	apo a-i deficiency	13.2	APOA1, ALB
30	thromboangiitis obliterans	13.2	SERPINE1, PLAT
31	familial hypertriglyceridemia	13.2	SERPINE1, APOA1
32	antithrombin iii deficiency	13.2	SERPINC1, FGA, F2
33	hepatic tuberculosis	13.2	F2, ALB
34	coronary stenosis	13.2	SERPINE1, FGA, APOA1
35	cerebral hemorrhage	13.1	SERPINF2, F2, PLAT
36	vericose veins	13.1	F2, ALB
37	peripheral vertigo	13.1	SERPINC1, F3, F2
38	warfarin resistance	13.1	F2, ALB
39	catastrophic antiphospholipid syndrome	13.1	SERPINE1, F3
40	esophageal varix	13.1	F2, ALB
41	acute myocarditis	13.1	FGA, PLAT
42	bernard-soulier syndrome	13.1	VWF, FGA, F2
43	factor vii deficiency	13.1	SERPINC1, F3, F2
44	intracranial thrombosis	13.1	SERPINC1, F2, PLAT
45	sycp3-related pregnancy loss, susceptibility to	13.1	SERPINC1, F3, F2
46	acquired von willebrand syndrome	13.1	VWF, F3, F2
47	neonatal stroke	13.1	SERPINE1, ALB
48	hemarthrosis	13.1	VWF, F3, F2
49	moyamoya disease	13.1	SERPINC1, F3, F2
50	hypersplenism	13.1	F2, ALB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypofibrinogenemia:

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MGI Mouse Phenotypes related to hypofibrinogenemia:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.9	UNC13D, FGG
2	immune system phenotype	MP:0005387	8.7	VWF, APOA1, F2, PLAT, UNC13D
3	liver/biliary system phenotype	MP:0005370	7.9	SERPINC1, SERPINE1, FGA, APOA1, ALB, CP
4	cardiovascular system phenotype	MP:0005385	6.8	APOA1, VWF, F3, FGG, FGA, SERPINE1
5	mortality/aging	MP:0010768	6.7	PRF1, PLAT, ALB, F2, VWF, SERPINC1
6	homeostasis/metabolism phenotype	MP:0005376	5.6	APOA1, FGG, FGA, F3, SERPINF2, SERPINC1

Articles related to hypofibrinogenemia:

id	Title	Authors	Year	Affiliating Genes
1	Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion. (18676163)	Plate M.... Duga S.	2008	FGB, FGA, FGG
2	Pathology teach and tell: fibrinogen storage disease in a child with hypofibrinogenemia and decreased ceruloplasmin. (17701692)	Bruzzi C.... Ahmed A.A.	2007	CP
3	Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia. (17650452)	Davis R.L.... Brennan S.O.	2007	FGG
4	Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency (18154029)	Hirota-Kawadobora M.... Katsuyama T.	2007	ALB
5	Fibrinogen angers with a new deletion (gamma GVYYQ 346-350) causes hypofibrinogenemia with hepatic storage. (17883696)	Dib N.... Cales P.	2007	FGG
6	Clinical and biological features of 3 cases of hypofibrinogenemia associated with three different mutations (gamma Ala341Thr, Bbeta Tyr326Cys and Aalpha Asp496Asn). (17849064)	Hanss M.... de Mazancourt P.	2007	FGB, FGA, FGG
7	Novel fibrinogen mutation (gamma 313 Ser-->Asn) associated with hypofibrinogenemia in two unrelated families. (16607083)	Meyer M.... Brennan S.O.	2006	FGG
8	Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis. (16819336)	Rubbia-Brandt L.... Spahr L.	2006	FGG
9	Hypofibrinogenemia caused by a nonsense mutation in the fibrinogen Bbeta chain gene. (14629469)	Mimuro J.... Sakata Y.	2003	FGB
10	A family with von Willebrand disease and hypofibrinogenemia (2246818)	Shinmyozu K.... Osame M.	1990	VWF

Genes related to hypofibrinogenemia according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	FGG	fibrinogen gamma chain	11.1	Publications, Summaries
2	FGA	fibrinogen alpha chain	11.1	Summaries, Publications
3	FGB	fibrinogen beta chain	11.0	Publications
4	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0
5	VWF	von Willebrand factor	11.0	Publications
6	PLAT	plasminogen activator, tissue	11.0
7	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0
8	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0
9	F3	coagulation factor III (thromboplastin, tissue factor)	11.0
10	F2	coagulation factor II (thrombin)	11.0
11	APOA1	apolipoprotein A-I	11.0
12	UNC13D	unc-13 homolog D (C. elegans)	11.0
13	STX11	syntaxin 11	11.0
14	PRF1	perforin 1 (pore forming protein)	11.0
15	CP	ceruloplasmin (ferroxidase)	11.0	Publications
16	ALB	albumin	11.0	Publications

Pathways related to hypofibrinogenemia according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_Integrin inside-out signaling41	9.8	FGA, FGB, FGG
2	Metalloproteases in connective tissue degradation10	9.8	FGA, FGB, FGG
3	Cell adhesion_Plasmin signaling41	9.6	FGB, FGA, FGG, PLAT
4	Cell adhesion Plasmin signaling10	9.6	FGB, FGG, FGA, PLAT
5	Cell adhesion Integrin inside-out signaling10	9.5	FGB, F2, FGG, FGA
6	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.3	VWF, F2, FGG, FGB, FGA
7	Platelet activation, signaling and aggregation38	9.3	VWF, FGA, FGB, FGG, APOA1
8	Intrinsic Prothrombin Activation Pathway36	9.3	SERPINC1, FGA, FGB, FGG, F2
9	Extrinsic Prothrombin Activation Pathway36	9.0	F2, FGB, F3, FGG, FGA, SERPINC1
10	Blood Coagulation Cascade36	9.0	F2, F3, FGG, FGB, FGA, SERPINC1
11	Immune response IL-1 signaling pathway10	8.9	SERPINE1, F3, CP
12	Immune response_IL-1 signaling pathway41	8.7	SERPINE1, F3, CP
13	Blood Coagulation Signaling Pathways37	8.4	FGB, SERPINE1, SERPINC1, F3, F2, PLAT
14	Complement and coagulation cascades20	7.9	PLAT, F3, VWF, FGG, FGB, FGA

Compounds related to hypofibrinogenemia according to GeneDecks:

(show top 50)    (show all 162)

id	Compound	Score	Top Affiliating Genes
1	clopidogrel32 34 9 18 9	14.5	SERPINC1
2	hepaplastin32	10.3	ALB
3	aspartate32	9.9	F2, APOA1
4	integrilin32	9.9	PLAT
5	abciximab32 9 9	11.8	F3, VWF, F2
6	tranexamic acid32 9 9	11.7	SERPINE1, PLAT, SERPINC1, VWF
7	eaca32	9.7	SERPINC1, SERPINF2, PLAT, SERPINE1
8	argatroban32 9 9	11.6	F3, F2, FGA, SERPINC1
9	11-dehydrothromboxane b232	9.6	VWF, SERPINE1, FGA, F2
10	sucralfate32 9 9	11.6	FGG, FGB, FGA, ALB
11	reviparin32	9.5	PLAT, SERPINC1, F3
12	spectrozyme32	9.5	SERPINC1, F3, F2, PLAT
13	fondaparinux32	9.5	F2, F3, PLAT, SERPINC1
14	certoparin32	9.5	SERPINC1, F3, F2
15	fibrinopeptide a32	9.5	SERPINC1, SERPINF2, FGA, F2, PLAT
16	batroxobin32	9.4	SERPINE1, FGB, F2, FGA, PLAT
17	hemochron32	9.4	F2, F3, FGA
18	ticlopidine32 9 9	11.4	FGA, VWF, SERPINC1, PLAT, F3
19	protamine sulfate32	9.4	PLAT, F2, F3, SERPINC1
20	ancrod32	9.4	F2, PLAT, FGA, SERPINC1, SERPINE1
21	bivalirudin32 9 9	11.3	FGA, F3, F2, PLAT, SERPINC1
22	dextran 7032	9.3	F2, F3, PLAT, ALB
23	tirofiban32 9 9	11.3	VWF, SERPINC1, F3, F2, PLAT
24	phenprocoumon32 34 9 9	12.2	SERPINC1, F3, F2, ALB
25	perindopril32 34 9 9	12.1	SERPINE1, VWF, ALB, PLAT
26	levonorgestrel32 9 9	11.1	SERPINC1, F3, PLAT, APOA1, F2
27	dipyridamole42 32 9 9	12.1	FGA, SERPINE1, VWF, F3, F2
28	ppack32	9.1	SERPINC1, VWF, FGA, F3, F2, PLAT
29	dermatan sulfate32	9.1	PLAT, F2, VWF, SERPINC1, F3
30	ristocetin32	9.1	SERPINC1, VWF, SERPINF2, PLAT, F2, F3
31	hydroxyethyl starch32	9.1	ALB, F3, SERPINC1, VWF, F2
32	epsilon aminocaproic acid32	9.0	SERPINC1, SERPINE1, SERPINF2, PLAT, F2, F3
33	desogestrel32 9 9	10.8	CP, F2, APOA1, SERPINC1
34	desmopressin32 42 9 9	11.8	F3, SERPINE1, SERPINF2, SERPINC1, VWF, F2
35	gestodene32 9 9	10.7	SERPINC1, APOA1, F2, CP
36	simvastatin32 34 42 9 18 9	13.7	F2, VWF, F3, APOA1, PLAT, SERPINE1
37	prostacyclin32	8.7	F3, APOA1, FGA, SERPINE1, SERPINC1, VWF
38	warfarin32 34 9 18 9	12.6	ALB, PLAT, VWF, F3, FGA, F2
39	aprotinin32 9 9	10.5	FGA, PLAT, SERPINE1, SERPINF2, SERPINC1, VWF
40	creatinine32	8.5	VWF, SERPINC1, FGA, APOA1, CP, F3
41	aspirin32 34 18	10.3	APOA1, F3, F2, PLAT, FGA, SERPINE1
42	hirudin32	8.3	FGA, VWF, SERPINC1, SERPINF2, SERPINE1, FGB
43	protamine32	8.2	FGA, SERPINC1, SERPINE1, CP, F2, F3
44	thyroxine32 18	9.0	VWF, PLAT, SERPINF2, APOA1, CP, ALB
45	kininogen32	7.8	F3, ALB, F2, VWF, PLAT, APOA1
46	heparin32 9 18 9	10.5	SERPINE1, F3, FGB, CP, FGA, ALB
47	homocysteine32 18	8.3	F3, F2, ALB, PLAT, CP, APOA1
48	cholesterol32 9 18 9	10.1	PLAT, PRF1, VWF, ALB, FGA, SERPINE1
49	serine32	6.4	SERPINE1, VWF, SERPINC1, FGA, SERPINF2, FGB
50	fibrinogen32	6.3	APOA1, FGG, FGA, SERPINE1, SERPINF2, SERPINC1

Cellular components related to hypofibrinogenemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell cortex	GO:005938	9.8	FGG, FGB, FGA
2	fibrinogen complex	GO:005577	9.6	FGG, FGB, FGA, SERPINF2
3	platelet alpha granule	GO:031091	9.5	FGG, FGB, FGA, VWF
4	external side of plasma membrane	GO:009897	9.2	VWF, FGA, FGG, FGB
5	extracellular matrix	GO:031012	9.2	PLAT, SERPINE1, VWF, F3
6	platelet alpha granule lumen	GO:031093	8.6	FGG, VWF, ALB, SERPINF2, SERPINE1, FGA
7	extracellular space	GO:005615	6.3	SERPINE1, FGA, FGB, FGG, APOA1, F3
8	extracellular region	GO:005576	5.7	FGB, FGG, FGA, SERPINE1, SERPINF2, SERPINC1

Biological processes related to hypofibrinogenemia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of plasminogen activation	GO:010757	10.0	SERPINE1, SERPINF2
2	protein polymerization	GO:051258	9.9	FGG, FGB, FGA
3	negative regulation of proteolysis	GO:045861	9.8	PLAT, F2
4	response to calcium ion	GO:051592	9.8	FGA, FGB, FGG
5	positive regulation of blood coagulation	GO:030194	9.7	SERPINE1, F2
6	negative regulation of fibrinolysis	GO:051918	9.7	SERPINE1, F2, SERPINF2
7	blood vessel morphogenesis	GO:048514	9.6	SERPINF2, PLAT
8	fibrinolysis	GO:042730	9.4	PLAT, F2, SERPINF2, SERPINE1
9	platelet degranulation	GO:002576	8.2	VWF, ALB, SERPINF2, SERPINE1, FGA, FGB
10	platelet activation	GO:030168	7.8	ALB, F2, APOA1, FGG, FGB, FGA
11	blood coagulation	GO:007596	6.9	FGA, SERPINF2, SERPINC1, VWF, FGB, FGG

Molecular functions related to hypofibrinogenemia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	9.6	SERPINF2, FGA, FGB, FGG
2	serine-type endopeptidase inhibitor activity	GO:004867	9.6	SERPINE1, SERPINF2, SERPINC1
3	protein binding, bridging	GO:030674	9.5	FGB, FGA, FGG
4	protease binding	GO:002020	9.1	VWF, SERPINC1, SERPINF2, SERPINE1, F3
5	receptor binding	GO:005102	9.0	SERPINE1, FGA, FGB, FGG, F2
6	chaperone binding	GO:051087	8.7	VWF, FGB, ALB, CP
7	protein binding	GO:005515	5.6	VWF, PRF1, STX11, PLAT, ALB, F2