MCID: HYP056
MIFTS: 61

Hypoglycemia malady

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Hypoglycemia

Summaries for Hypoglycemia

MedlinePlus : 41 hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 5 and microcephaly, short stature, and impaired glucose metabolism, and has symptoms including sugar craving An important gene associated with Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Heparin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 71 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 406)
id Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 5 33.2 IGF1 INS INSR
2 microcephaly, short stature, and impaired glucose metabolism 31.5 ABCC8 HADH
3 hyperinsulinemic hypoglycemia, familial, 2 12.2
4 hyperinsulinemic hypoglycemia 12.2
5 hyperinsulinemic hypoglycemia, familial, 1 12.2
6 hypoglycemia of infancy, leucine-sensitive 12.1
7 hyperinsulinemic hypoglycemia, familial, 7 12.1
8 hyperinsulinemic hypoglycemia, familial, 3 12.1
9 hyperinsulinemic hypoglycemia, familial, 4 12.1
10 hypoinsulinemic hypoglycemia with hemihypertrophy 12.0
11 fasting hypoglycemia 11.9
12 hypoketonemic hypoglycemia 11.7
13 hyperinsulinism-hyperammonemia syndrome 11.7
14 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 11.7
15 glycogen storage disease 0, liver 11.5
16 insulin autoimmune syndrome 11.4
17 glycogen storage disease type 0 11.4
18 cpt deficiency, hepatic, type ii 11.2
19 carnitine-acylcarnitine translocase deficiency 11.2
20 hyperinsulinism 11.0
21 beckwith-wiedemann syndrome 10.9
22 fructose-1,6-bisphosphatase deficiency 10.9
23 carnitine palmitoyltransferase ii deficiency 10.9
24 galactosemia 10.9
25 diencephalic syndrome 10.9
26 fructose intolerance 10.8
27 cpt deficiency, hepatic, type ia 10.8
28 brittle diabetes 10.8
29 insr-related hyperinsulinism 10.8
30 glycogen storage disease ia 10.8
31 glucocorticoid deficiency 4 10.8
32 carnitine deficiency, systemic primary 10.8
33 hmg-coa lyase deficiency 10.8
34 glycogen storage disease iiia 10.8
35 vlcad deficiency 10.8
36 glutaric acidemia iic 10.7
37 mitochondrial dna depletion syndrome 3 10.7
38 dopamine beta-hydroxylase deficiency 10.7
39 glucocorticoid deficiency, due to acth unresponsiveness 10.7
40 tenorio syndrome 10.7
41 glycogen storage disease vi 10.7
42 glucocorticoid resistance 10.7
43 glucocorticoid deficiency 2 10.7
44 barth syndrome 10.7
45 silver-russell syndrome 10.7
46 malonyl-coa decarboxylase deficiency 10.7
47 lchad deficiency 10.7
48 glycogen storage disease ib 10.7
49 hyperammonemia due to carbonic anhydrase va deficiency 10.7
50 hmg-coa synthase-2 deficiency 10.7

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:


sugar craving

MGI Mouse Phenotypes related to Hypoglycemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ABCC8 ACADL ACADM CRH G6PC GCK
2 growth/size/body region MP:0005378 10.18 CRH G6PC GCK GLUD1 HADH IGF1
3 endocrine/exocrine gland MP:0005379 10.14 ABCC8 CRH GCK GLUD1 HADH IGF1
4 adipose tissue MP:0005375 10.03 INSR KCNJ11 CRH HADH IGF1 INS
5 liver/biliary system MP:0005370 10 INS INSR POMC SLC16A1 ACADL ACADM
6 mortality/aging MP:0010768 9.97 ACADL ACADM G6PC GCK IGF1 IGF2
7 no phenotypic analysis MP:0003012 9.5 ABCC8 CRH IGF2 INS KCNJ11 POMC
8 renal/urinary system MP:0005367 9.32 ACADL CRH G6PC GCK HADH IGF1

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 461)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
2
Glyburide Approved Phase 4,Phase 2,Phase 3,Phase 1 10238-21-8 3488
3
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
4
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
5
Diazoxide Approved Phase 4,Phase 2,Phase 3 364-98-7 3019
6
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
7
Gliclazide Approved Phase 4,Phase 3,Phase 2 21187-98-4 3475
8
Glipizide Approved Phase 4,Phase 3 29094-61-9 3478
9
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
10
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 383414 6400441
11
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 5754 657311
12
lanreotide Approved Phase 4 108736-35-2
13
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 141758-74-9 15991534
14
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
15
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
16
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1 204656-20-2
17
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
18
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
19
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
20
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
21
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
22
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
23
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
24
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
25
Somatostatin Approved Phase 4,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
26
Ethanol Approved Phase 4,Phase 2,Phase 1 64-17-5 702
27
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
28
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
29
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
30
Epinephrine Approved, Vet_approved Phase 4,Early Phase 1 51-43-4 5816
31
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1 93479-97-1 3476
32
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
33
Acarbose Approved, Investigational Phase 4,Phase 2 56180-94-0 441184
34
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2 151126-32-8
35
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
36
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
37
Fosaprepitant Approved Phase 4 172673-20-0 219090
38
Gliquidone Approved Phase 4 33342-05-1 91610
39
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
40
Linagliptin Approved Phase 4,Phase 3 668270-12-0 10096344
41
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
42
Ezetimibe Approved Phase 4 163222-33-1 150311
43
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
44
Doxazosin Approved Phase 4 74191-85-8 3157
45
Phenoxybenzamine Approved Phase 4 59-96-1 4768
46
Verapamil Approved Phase 4 52-53-9 2520
47
Memantine Approved, Investigational Phase 4 19982-08-2 4054
48 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
50
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793

Interventional clinical trials:

(show top 50) (show all 1594)
id Name Status NCT ID Phase
1 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4
2 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4
3 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4
4 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4
5 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4
6 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
7 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4
8 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4
9 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4
10 Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes Unknown status NCT00736515 Phase 4
11 Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 DM Unknown status NCT01338922 Phase 4
12 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
13 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4
14 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4
15 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
16 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4
17 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4
18 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4
19 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4
20 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4
21 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4
22 The Efficacy of Glucerna SR in Chinese Drug-naïve Subjects With Type 2 Diabetes Unknown status NCT02248714 Phase 4
23 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4
24 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
25 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4
26 Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (The CGM TIME Trial) Unknown status NCT01295788 Phase 4
27 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4
28 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4
29 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4
30 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4
31 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4
32 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4
33 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4
34 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4
35 Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial) Completed NCT00390728 Phase 4
36 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
37 Phase 4 Study in the Elderly Patients With T2DM Completed NCT01238978 Phase 4
38 Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 in Type 2 Diabetes Completed NCT01487798 Phase 4
39 The Incidence of Hypoglycemia in Insulin Glargine-Treated Subjects With Diabetes Mellitus Upon Switching Between Bedtime and Morning Dosing Completed NCT00609895 Phase 4
40 The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass Surgery Completed NCT02336438 Phase 4
41 Glucagon Efficiency After High and Low Carbohydrate Diet Completed NCT02578498 Phase 4
42 Efficacy and Safety of Insulin Aspart vs. Human Insulin During Pregnancy by Women With Type 1 Diabetes Completed NCT00365170 Phase 4
43 Lantus Versus Levemir Treat-To-Target Completed NCT00405418 Phase 4
44 Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride Completed NCT02007278 Phase 4
45 Liraglutide in Type 1 Diabetes Completed NCT01612468 Phase 4
46 A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar With Type 2 Diabetes Mellitus Completed NCT00399724 Phase 4
47 Evaluation of the Safety and Efficacy of Insulin Glargine + Glulisine or Insulin Regular + NPH Insulin (Isophane Insulin) Use in Type 2 Diabetes Mellitus Patients With Moderate Renal Failure. Completed NCT01122979 Phase 4
48 Self Titration With Apidra to Reach Target Study (START) Completed NCT01013571 Phase 4
49 An Observational Study to Evaluate Tolerability of Canagliflozin and Sulphonylurea in Type 2 Diabetes Patients During Ramadan Completed NCT02737657 Phase 4
50 Evaluate Quality of Life in Type 2 Diabetes, Before and After Change to Insuline Glargine Completed NCT00518427 Phase 4

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

id Genetic test Affiliating Genes
1 Hypoglycemia 29

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

39
Liver, Testes, Kidney, Brain, Pituitary, Pancreas, Endothelial

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 1569)
id Title Authors Year
1
Factors Affecting the Ability of People With Diabetes to Avoid Hypoglycemia. ( 28079649 )
2017
2
50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey. ( 28010802 )
2017
3
Central Congenital Hypoventilation Syndrome associated with hypoglycemia and seizure. ( 28070480 )
2017
4
Letter to the Editor: Intranasal Glucagon for Hypoglycemia. ( 28091864 )
2017
5
Paroxysmal sympathetic hyperactivity after symptomatic hypoglycemia. ( 28084274 )
2017
6
Hypoglycemia Evaluation and Reporting in Diabetes: Importance for the Development of New Therapies. ( 28054743 )
2017
7
50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey. ( 28010803 )
2017
8
Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma. ( 28225059 )
2017
9
Hypoglycemia identified by a continuous glucose monitoring system in a second-trimester pregnant woman with insulinoma: a case report. ( 28427440 )
2017
10
Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery. ( 28083850 )
2017
11
Sporadic Insulinoma as a Rare Cause of Recurrent Hypoglycemia in Children. ( 28512591 )
2017
12
Exaggerated glucagon responses to hypoglycemia in women with polycystic ovary syndrome. ( 28521865 )
2017
13
Glycogen storage disease type IX and growth hormone deficiency presenting as severe ketotic hypoglycemia. ( 28085675 )
2017
14
Postprandial hypoglycemia as the only manifestation of insulinoma: exceptional case report. ( 28416239 )
2017
15
Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia. ( 28056431 )
2017
16
Insulin Autoimmune Syndrome: a rare cause of postprandial hypoglycemia. ( 27855237 )
2016
17
Nocturnal Hypoglycemia and Physical Activity in Children With Diabetes: New Insights by Continuous Glucose Monitoring and Accelerometry. ( 27208338 )
2016
18
Glycemic Control Indices and Their Aggregation in the Prediction of Nocturnal Hypoglycemia From Intermittent Blood Glucose Measurements. ( 27660190 )
2016
19
Single incision laparoscopic 90A % pancreatectomy for the treatment of persistent hyperinsulinemic hypoglycemia of infancy. ( 27473008 )
2016
20
Shwachman-Diamond syndrome presenting with early ichthyosis, associated dermal and epidermal intracellular lipid droplets, hypoglycemia, and later distinctive clinical SDS phenotype. ( 27127007 )
2016
21
Self-reported frequency, severity of, and awareness of hypoglycemia in type 2 diabetes patients in Turkey. ( 27994961 )
2016
22
Synchronous Nesidioblastosis, Endocrine Microadenoma, and Intraductal Papillary Mucinous Neoplasia in a Man Presenting With Hyperinsulinemic Hypoglycemia. ( 26658039 )
2016
23
Erratum to "Hypoglycemia and risk of seizures: A retrospective cross-sectional study" [Seizure (2015) 147-149]. ( 28033556 )
2016
24
Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. ( 27150868 )
2016
25
Assessment of Nifedipine therapy in Hyperinsulinemic Hypoglycemia due to mutations in the ABCC8 gene. ( 27898257 )
2016
26
Moringa Oleifera leaf extract increases plasma antioxidant status associated with reduced plasma malondialdehyde concentration without hypoglycemia in fasting healthy volunteers. ( 28035536 )
2016
27
Inclusion of Hypoglycemia in Clinical Practice Guidelines and Performance Measures in the Care of Patients With Diabetes. ( 27653613 )
2016
28
Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management System. ( 27148807 )
2016
29
Hypoglycemia due to monoclonal anti-insulin antibody in a patient with multiple myeloma. ( 27216935 )
2016
30
Comment on Rickels et al. Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study. Diabetes Care 2016;39:264-270. ( 27660134 )
2016
31
Letter to the Editor: Endocrine and metabolic emergencies in children: hypocalcemia, hypoglycemia, adrenal insufficiency, and metabolic acidosis including diabetic ketoacidosis. ( 27464241 )
2016
32
Evaluation of Blood Glucose Monitoring System in Screening for Neonatal Hypoglycemia: Tighter Accuracy Standard. ( 27633318 )
2016
33
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( 26598136 )
2016
34
Non-insulinoma Pancreatogeneous Hypoglycemia Syndrome with False-Positive Somatostatin Receptor Scintigraphy: A Case Report and Review of Literature. ( 27276748 )
2016
35
Hyperinsulinemic Hypoglycemia of Infancy due to Novel HADH Mutation in Two Siblings. ( 27771675 )
2016
36
Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial. ( 27209482 )
2016
37
Generalized Anxiety Disorder and Hypoglycemia Symptoms Improved with Diet Modification. ( 27493821 )
2016
38
Correlates and outcomes of worries about hypoglycemia in family members of adults with diabetes: The second Diabetes Attitudes, Wishes and Needs (DAWN2) study. ( 27663113 )
2016
39
Current Status of Childhood Hyperinsulinemic Hypoglycemia in Turkey. ( 27181376 )
2016
40
Preventing Unnecessary Costs of Drug-Induced Hypoglycemia in Older Adults with Type 2 Diabetes in the United States and Canada. ( 27648831 )
2016
41
No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3A Years After Gastric Bypass Surgery. ( 27138601 )
2016
42
Novel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2 (UCP2). ( 27967291 )
2016
43
Pancreatic Uptake by 18F-FDOPA PET/CT in Patients With Hypoglycemia After Gastric Bypass Surgery Compared With Controls With or Without Carbidopa Pretreatment. ( 28005639 )
2016
44
Severe hypoglycemia, impaired awareness of hypoglycemia, and self-monitoring in adults with type 1 diabetes: Results from Diabetes MILES-Australia. ( 27993524 )
2016
45
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. ( 27208344 )
2016
46
Response to Comment on Rickels et al. Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study. Diabetes Care 2016;39:264-270. ( 27660135 )
2016
47
Use of a Novel Smartphone-Based Diabetes Management System Improved Feelings of Confidence and Safety and Reduced Hypoglycemia Fear Among Parents/Caregivers of Children/Adolescents With Type 1 Diabetes. ( 27207891 )
2016
48
Long-Term Prediction of Severe Hypoglycemia in Type 1 Diabetes: Is It Really Possible? ( 27651425 )
2016
49
The Author Reply: Endocrine and metabolic emergencies in children: hypocalcemia, hypoglycemia, adrenal insufficiency, and metabolic acidosis including diabetic ketoacidosis. ( 27462590 )
2016
50
Hypoglycemia - Old foe with a new face - Masquerading as an acute stroke. ( 27994388 )
2016

Variations for Hypoglycemia

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for Hypoglycemia

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 ABCC8 ACADL ACADM FBP1 G6PC GCG
2
Show member pathways
12.72 FBP1 G6PC GCK GYS2 IGF1 INS
3 12.47 G6PC GYS2 IGF1 INS INSR
4
Show member pathways
12.39 FBP1 G6PC GYS2 INS INSR
5 12.34 FBP1 GCG GLUD1 INS INSR
6
Show member pathways
12.28 ABCC8 GCG INS KCNJ11
7
Show member pathways
12.23 ACADM FBP1 GCK GLUD1
8
Show member pathways
12.23 ABCC8 GCG GCK INS KCNJ11
9
Show member pathways
12.22 FBP1 G6PC GYS2 IGF1 INS INSR
10
Show member pathways
12.15 GCG IGF1 INS POMC
11 12.06 ACADM G6PC GCK SST
12
Show member pathways
11.96 G6PC IGF1 INS INSR
13 11.8 IGF1 INS INSR
14
Show member pathways
11.8 G6PC GYS2 INS INSR
15
Show member pathways
11.77 ACADL ACADM HADH
16 11.76 ACADM GLUD1 HADH
17
Show member pathways
11.59 ACADL ACADM HADH
18 11.57 FBP1 G6PC GCG GCK GYS2
19 11.48 IGF1 IGF2 INS
20 11.46 ABCC8 GYS2 KCNJ11
21 11.43 IGF1 INS INSR
22
Show member pathways
11.39 ACADL ACADM HADH SLC25A20
23
Show member pathways
11.34 ABCC8 GCK INS INSR KCNJ11
24 11.24 IGF1 INS INSR
25 10.81 ABCC8 ACADM G6PC GCK HADH INS
26
Show member pathways
10.61 ACADM HADH
27 10.44 CRH POMC

GO Terms for Hypoglycemia

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.28 ABCC8 ACADL ACADM GCK GLUD1 HADH
2 ATP-sensitive potassium channel complex GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 ABCC8 CRH HADH KCNJ11 SST
2 carbohydrate metabolic process GO:0005975 9.85 FBP1 GCK IGF2 INS INSR
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 IGF1 IGF2 INS
4 positive regulation of protein kinase B signaling GO:0051897 9.79 IGF2 INS INSR
5 insulin receptor signaling pathway GO:0008286 9.78 IGF2 INS INSR
6 fatty acid beta-oxidation GO:0006635 9.74 ACADL ACADM HADH
7 positive regulation of DNA replication GO:0045740 9.72 IGF1 INS INSR
8 positive regulation of MAPK cascade GO:0043410 9.71 IGF1 IGF2 INS INSR
9 glucose transport GO:0015758 9.7 G6PC GCK INS
10 negative regulation of insulin secretion GO:0046676 9.67 ABCC8 HADH KCNJ11
11 glucose metabolic process GO:0006006 9.67 GCK IGF2 INS KCNJ11
12 positive regulation of glucose import GO:0046326 9.65 IGF1 INS INSR
13 glucose homeostasis GO:0042593 9.65 G6PC GCK INS INSR SLC16A1
14 cellular glucose homeostasis GO:0001678 9.64 ABCC8 GCK
15 negative regulation of gluconeogenesis GO:0045721 9.64 GCK INS
16 positive regulation of insulin receptor signaling pathway GO:0046628 9.63 IGF2 INS
17 activation of protein kinase B activity GO:0032148 9.61 IGF1 INS INSR
18 regulation of gluconeogenesis GO:0006111 9.6 ACADM FBP1
19 glucose 6-phosphate metabolic process GO:0051156 9.59 G6PC GCK
20 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.58 ACADL ACADM
21 positive regulation of respiratory burst GO:0060267 9.58 INS INSR
22 hormone-mediated apoptotic signaling pathway GO:0008628 9.54 CRH SST
23 carnitine metabolic process, CoA-linked GO:0019254 9.51 ACADL ACADM
24 positive regulation of glycolytic process GO:0045821 9.5 IGF1 INS INSR
25 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF1 IGF2 INS INSR
26 regulation of insulin secretion GO:0050796 9.35 ABCC8 GCG GCK KCNJ11 SLC16A1
27 positive regulation of glycogen biosynthetic process GO:0045725 9.02 GCK IGF1 IGF2 INS INSR
28 positive regulation of cell proliferation GO:0008284 10.02 CRH IGF1 IGF2 INS INSR
29 metabolic process GO:0008152 10.02 ACADL ACADM FBP1 GCK GYS2

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NAD+ binding GO:0070403 9.37 GLUD1 HADH
2 insulin receptor binding GO:0005158 9.33 IGF1 IGF2 INS
3 acyl-CoA dehydrogenase activity GO:0003995 9.32 ACADL ACADM
4 ATP-activated inward rectifier potassium channel activity GO:0015272 9.26 ABCC8 KCNJ11
5 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 IGF2 INS INSR
6 hormone activity GO:0005179 9.17 CRH GCG IGF1 IGF2 INS POMC

Sources for Hypoglycemia

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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68 Tocris
69 UMLS
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