MCID: HYP056
MIFTS: 60

Hypoglycemia

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Hypoglycemia

Summaries for Hypoglycemia

MedlinePlus : 41 hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 4 and glycogen storage disease iiia, and has symptoms including sugar craving An important gene associated with Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Glyburide and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and brain, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 72 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)
id Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 4 32.1 ACADM ACADVL GCK GLUD1 HADH INS
2 glycogen storage disease iiia 31.4 AGL G6PC GCG
3 fructose intolerance, hereditary 31.1 AGL FBP1 G6PC GCG
4 acyl-coa dehydrogenase, medium chain, deficiency of 30.5 ACADL ACADM ACADVL
5 cataract 29.1 CRH INS
6 hypertrichosis 29.0 ABCC8 G6PC GCG GCK INS KCNJ11
7 hyperinsulinemic hypoglycemia, familial, 2 12.2
8 hyperinsulinemic hypoglycemia 12.2
9 hyperinsulinemic hypoglycemia, familial, 1 12.1
10 hypoglycemia of infancy, leucine-sensitive 12.1
11 hyperinsulinemic hypoglycemia, familial, 7 12.1
12 hyperinsulinemic hypoglycemia, familial, 3 12.1
13 hypoinsulinemic hypoglycemia with hemihypertrophy 12.0
14 fasting hypoglycemia 11.9
15 hyperinsulinism-hyperammonemia syndrome 11.7
16 hypoketonemic hypoglycemia 11.7
17 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 11.7
18 glycogen storage disease 0, liver 11.5
19 insulin autoimmune syndrome 11.4
20 cpt ii deficiency, infantile 11.3
21 carnitine-acylcarnitine translocase deficiency 11.2
22 glycogen storage disease type 0 11.0
23 hyperinsulinism 11.0
24 beckwith-wiedemann syndrome 10.9
25 fructose-1,6-bisphosphatase deficiency 10.9
26 cpt deficiency, hepatic, type ia 10.9
27 galactosemia 10.9
28 carnitine palmitoyltransferase ii deficiency 10.9
29 mitochondrial complex iii deficiency 10.9
30 pancreatic neuroendocrine tumor 10.9
31 brittle diabetes 10.8
32 carnitine palmitoyltransferase i deficiency , muscle 10.8
33 hyperphosphatasia with mental retardation syndrome 6 10.8 ABCC8 HADH
34 glucocorticoid deficiency 4, with or without mineralocorticoid deficiency 10.8
35 carnitine deficiency, systemic primary 10.8
36 glycogen storage disease ia 10.8
37 glucocorticoid deficiency 2 10.8
38 hmg-coa lyase deficiency 10.8
39 trifunctional protein deficiency 10.8
40 vlcad deficiency 10.8
41 diabetes mellitus, permanent neonatal 10.7 ABCC8 GCK
42 diabetes mellitus, transient neonatal, 3 10.7 ABCC8 KCNJ11
43 palmoplantar keratoderma and woolly hair 10.7 ABCC8 INSR
44 intellectual deficit buenos-aires type 10.7 INS INSR
45 familial hyperinsulinsism 10.7
46 insr-related hyperinsulinism 10.7
47 slc16a1-related hyperinsulinism 10.7
48 hyperinsulinism due to hnf4a deficiency 10.7
49 hyperinsulinism due to ucp2 deficiency 10.7
50 hyperinsulinism due to hnf1a deficiency 10.7

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:


sugar craving

MGI Mouse Phenotypes related to Hypoglycemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 SLC25A20 ABCC8 ACADL ACADM ACADVL AGL
2 growth/size/body region MP:0005378 10.15 INSR KCNJ11 SLC16A1 ACADVL AKT2 CRH
3 endocrine/exocrine gland MP:0005379 10.1 ABCC8 AKT2 CRH GCK GLUD1 HADH
4 liver/biliary system MP:0005370 10.07 ACADM ACADVL AGL AKT2 CRH G6PC
5 adipose tissue MP:0005375 10.03 ACADVL AKT2 CRH HADH INS INSR
6 mortality/aging MP:0010768 9.97 ACADL ACADM ACADVL AGL AKT2 G6PC
7 muscle MP:0005369 9.61 AKT2 GYS2 IGF2 INS INSR KCNJ11
8 renal/urinary system MP:0005367 9.23 ACADL CRH G6PC GCK HADH IGF2

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 472)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4,Phase 2,Phase 3,Phase 1 10238-21-8 3488
2
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
3
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Diazoxide Approved Phase 4,Phase 2,Phase 3,Phase 1 364-98-7 3019
5
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
6
Glipizide Approved Phase 4,Phase 3 29094-61-9 3478
7
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
8
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
9
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
10
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
11
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
12 lanreotide Approved Phase 4 108736-35-2
13
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 383414 6400441
14
Somatostatin Approved Phase 4,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
15
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
16
Acarbose Approved, Investigational Phase 4,Phase 2 56180-94-0 441184
17
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1 93479-97-1 3476
18
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1 204656-20-2 44147092
19
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
20
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
21
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
22
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
23
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 5754 657311
24
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 141758-74-9 15991534
25
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
26
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
27
Epinephrine Approved, Vet_approved Phase 4,Early Phase 1 51-43-4 5816
28 Racepinephrine Approved Phase 4,Early Phase 1
29
Ethanol Approved Phase 4,Phase 2,Phase 1 64-17-5 702
30
Gliclazide Approved Phase 4,Phase 3,Phase 2 21187-98-4 3475
31
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
32
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
33
Fosaprepitant Approved Phase 4 172673-20-0 219090
34
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2 151126-32-8
35
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
36
Linagliptin Approved Phase 4,Phase 3 668270-12-0 10096344
37
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
38
Gliquidone Approved Phase 4 33342-05-1 91610
39
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
40
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
41
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
42
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
43
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
44
Ezetimibe Approved Phase 4 163222-33-1 150311
45
Doxazosin Approved Phase 4 74191-85-8 3157
46
Phenoxybenzamine Approved Phase 4 59-96-1 4768
47
Protein C Approved Phase 4,Phase 2
48
Verapamil Approved Phase 4 52-53-9 2520
49
Memantine Approved, Investigational Phase 4 19982-08-2 4054
50 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1650)

id Name Status NCT ID Phase Drugs
1 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4 Lactate;Glucose
2 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
3 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
4 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
5 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
6 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
7 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
8 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
9 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
10 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
11 Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 DM Unknown status NCT01338922 Phase 4
12 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
13 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
14 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
15 Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients Unknown status NCT02462369 Phase 4 Saxagliptin;glimepiride
16 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
17 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
18 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
19 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
20 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
21 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4 Galvus (vildagliptin);pioglitazone
22 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
23 The Efficacy of Glucerna SR in Chinese Drug-naïve Subjects With Type 2 Diabetes Unknown status NCT02248714 Phase 4
24 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
25 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
26 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Unknown status NCT02517242 Phase 4
27 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
28 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4 Transient Continuous Subcutaneous Insulin Infusion;Transient Multiple Daily Insulin Injections
29 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4 Switching to NPH insulin;Continuation of insulin glargine
30 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4 Lixisenatide
31 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
32 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4 Vildagliptin
33 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
34 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4 Vildagliptin
35 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4 Human insulin;Human Insulin
36 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
37 Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial) Completed NCT00390728 Phase 4 Insulin Glargine
38 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
39 Phase 4 Study in the Elderly Patients With T2DM Completed NCT01238978 Phase 4 Vildagliptin;"Usual Care"
40 Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 in Type 2 Diabetes Completed NCT01487798 Phase 4 biphasic human insulin 30;biphasic insulin aspart 30
41 Sitagliptin and Glucagon Counterregulation Completed NCT02256189 Phase 4 Sitagliptin;Placebo
42 The Incidence of Hypoglycemia in Insulin Glargine-Treated Subjects With Diabetes Mellitus Upon Switching Between Bedtime and Morning Dosing Completed NCT00609895 Phase 4 INSULIN GLARGINE
43 The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass Surgery Completed NCT02336438 Phase 4
44 Glucagon Efficiency After High and Low Carbohydrate Diet Completed NCT02578498 Phase 4
45 The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Completed NCT02881060 Phase 4
46 Efficacy and Safety of Insulin Aspart vs. Human Insulin During Pregnancy by Women With Type 1 Diabetes Completed NCT00365170 Phase 4 human insulin;insulin aspart
47 Lantus Versus Levemir Treat-To-Target Completed NCT00405418 Phase 4 Insulin glargine;Insulin Detemir
48 Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride Completed NCT02007278 Phase 4 vildagliptin and metformin (combination);glimepiride;Metformin
49 Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263) Completed NCT01131182 Phase 4 Sitagliptin phosphate;Comparator: Sulfonylurea;Metformin
50 Liraglutide in Type 1 Diabetes Completed NCT01612468 Phase 4 Liraglutide;Placebo

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

id Genetic test Affiliating Genes
1 Hypoglycemia 29

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

39
Pancreas, Testes, Brain, Liver, Kidney, Heart, Pancreatic Islet

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 1609)
id Title Authors Year
1
50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey. ( 28010802 )
2017
2
Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma. ( 28225059 )
2017
3
Hypoglycemia in Diabetes Mellitus. ( 28857877 )
2017
4
A Case of Non-Islet Cell Tumor Hypoglycemia (NICTH) Associated with Gastrointestinal Stromal Tumor (GIST). ( 28900071 )
2017
5
Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma. ( 28785493 )
2017
6
Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia. ( 28715810 )
2017
7
Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery. ( 28083850 )
2017
8
Hypothalamic Glucose Transport in Humans During Experimentally Induced Hypoglycemia-Associated Autonomic Failure. ( 28911152 )
2017
9
Recent Exposure to Hypoglycemia Increases Glucose Variability Following a Hyper/Hypoglycemic Metabolic Challenge in T1D. ( 28942668 )
2017
10
Portosystemic shunt as a cause of congenital hyperinsulinemic hypoglycemia. ( 28401743 )
2017
11
SYK protects cardiocytes against anoxia and hypoglycemia-induced injury in ischemic heart failure. ( 28869869 )
2017
12
Octreotide LAR was useful for avoiding hypoglycemia in an elderly patient with insulinoma. ( 28592737 )
2017
13
Hypoglycemia identified by a continuous glucose monitoring system in a second-trimester pregnant woman with insulinoma: a case report. ( 28427440 )
2017
14
Central Congenital Hypoventilation Syndrome associated with hypoglycemia and seizure. ( 28070480 )
2017
15
Frequency and Predictors of Self-Reported Hypoglycemia in Insulin-Treated Diabetes. ( 28913365 )
2017
16
Derivation and validation model for hospital hypoglycemia. ( 28882417 )
2017
17
Levels of glucose-regulatory hormones in patients with non-islet cell tumor hypoglycemia: including a review of the literature. ( 28529277 )
2017
18
Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome. ( 28461453 )
2017
19
Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. ( 28928117 )
2017
20
Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia. ( 28235848 )
2017
21
Doege-Potter Syndrome, cause of nonislet cell tumor hypoglycemia: the first case report from Nepal. ( 28860867 )
2017
22
Factors Affecting the Ability of People With Diabetes to Avoid Hypoglycemia. ( 28079649 )
2017
23
A Pilot Observational Study of Hypoglycemia: Patient Reporting Using a Web-Based Portal Compared to Paper Surveys. ( 28918651 )
2017
24
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. ( 28887311 )
2017
25
Self-reported hypoglycemia in insulin-treated patients with diabetes: Results from an international survey on 7289 patients from nine countries. ( 28951336 )
2017
26
Fasting Hypoglycemia on (18)F-FDG PET/CT Scan. ( 28420855 )
2017
27
Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia. ( 28056431 )
2017
28
Impact of a Basal-Bolus Insulin Regimen on Metabolic Control and Risk of Hypoglycemia in Patients With Diabetes Undergoing Peritoneal Dialysis. ( 28927285 )
2017
29
Glycogen storage disease type IX and growth hormone deficiency presenting as severe ketotic hypoglycemia. ( 28085675 )
2017
30
UQCRC2 mutation in a patient with mitochondrial complex III deficiency causing recurrent liver failure, lactic acidosis and hypoglycemia. ( 28275242 )
2017
31
Paroxysmal sympathetic hyperactivity after symptomatic hypoglycemia. ( 28084274 )
2017
32
Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann, Sotos, and Kabuki syndromes: A nationwide survey in Japan. ( 28102591 )
2017
33
Sporadic Insulinoma as a Rare Cause of Recurrent Hypoglycemia in Children. ( 28512591 )
2017
34
Octreotide therapy and restricted fetal growth: pregnancy in familial hyperinsulinemic hypoglycemia. ( 28458896 )
2017
35
Effect of Exercise-Induced Lactate Elevation on Brain Lactate Levels During Hypoglycemia in Patients with Type 1 Diabetes and Impaired Awareness of Hypoglycemia. ( 28935628 )
2017
36
50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy. ( 28947056 )
2017
37
Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse. ( 28588806 )
2017
38
A Case of Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring. ( 28943561 )
2017
39
Postprandial hyperinsulinemic hypoglycemia in a child as a late complication of esophageal reconstruction. ( 28693122 )
2017
40
Hypoglycemia Evaluation and Reporting in Diabetes: Importance for the Development of New Therapies. ( 28054743 )
2017
41
Postprandial hypoglycemia as the only manifestation of insulinoma: exceptional case report. ( 28416239 )
2017
42
Conditional Tissue-Specific Foxa2 Ablation in Mouse Pancreas Causes Hyperinsulinemic Hypoglycemia: RETRACTED. ( 28288081 )
2017
43
Postprandial hyperinsulinemic hypoglycemia in a child as a late complication of esophageal reconstruction. ( 28672750 )
2017
44
Hypoglycemia awareness among insulin-treated patients with diabetes in Malaysia: A cohort subanalysis of the HAT study. ( 28888148 )
2017
45
Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population. ( 28913363 )
2017
46
Hyperinsulinemic hypoglycemia: clinical, molecular and therapeutical novelties. ( 28656511 )
2017
47
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction. ( 28216384 )
2017
48
Diagnosis of congenital hyperinsulinism: Biochemical profiles during hypoglycemia. ( 28597971 )
2017
49
Dipyrone in association with atropine inhibits the effect on gastric emptying induced by hypoglycemia in rats. ( 28876363 )
2017
50
50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey. ( 28010803 )
2017

Variations for Hypoglycemia

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for Hypoglycemia

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 ABCC8 ACADL ACADM ACADVL AGL FBP1
2
Show member pathways
12.83 AKT2 FBP1 G6PC GCK GYS2 INS
3
Show member pathways
12.81 ACADL ACADM ACADVL HADH SLC25A20
4
Show member pathways
12.78 AGL FBP1 G6PC GCK GYS2
5
Show member pathways
12.58 AGL FBP1 G6PC GCK GYS2
6
Show member pathways
12.44 AKT2 FBP1 G6PC GYS2 INS INSR
7 12.4 AKT2 FBP1 GCG GLUD1 INS INSR
8
Show member pathways
12.33 ABCC8 GCG GCK INS KCNJ11
9
Show member pathways
12.3 AKT2 FBP1 G6PC GYS2 INS INSR
10
Show member pathways
12.27 ABCC8 GCG INS KCNJ11
11
Show member pathways
12.23 ACADM FBP1 GCK GLUD1
12
Show member pathways
12.12 AKT2 GYS2 INS INSR
13
Show member pathways
12.01 AKT2 G6PC INS INSR
14
Show member pathways
11.94 AGL G6PC GCK GYS2
15
Show member pathways
11.8 AKT2 GCK INS
16
Show member pathways
11.8 AKT2 G6PC GYS2 INS INSR
17 11.79 AKT2 INS INSR
18
Show member pathways
11.79 ACADL ACADM ACADVL HADH
19 11.75 ACADM GLUD1 HADH
20
Show member pathways
11.7 ABCC8 GCK INS INSR KCNJ11
21
Show member pathways
11.62 ACADL ACADM ACADVL HADH
22 11.5 AKT2 INS INSR
23 11.45 ABCC8 AKT2 GYS2 KCNJ11
24 11.45 AKT2 FBP1 G6PC GCG GCK GYS2
25 11.39 AKT2 INS INSR
26
Show member pathways
11.28 ACADL ACADM ACADVL HADH SLC25A20
27 11.19 AKT2 INS INSR
28 10.87 ABCC8 ACADM ACADVL G6PC GCK HADH

GO Terms for Hypoglycemia

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 9.55 ACADL ACADM ACADVL GLUD1 HADH
2 mitochondrion GO:0005739 9.32 ABCC8 ACADL ACADM ACADVL GCK GLUD1
3 ATP-sensitive potassium channel complex GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.98 ACADL ACADM ACADVL AGL FBP1 GCK
2 positive regulation of cell proliferation GO:0008284 9.93 CRH IGF2 INS INSR
3 positive regulation of protein phosphorylation GO:0001934 9.88 AKT2 CRH IGF2 INSR
4 fatty acid metabolic process GO:0006631 9.86 ACADL ACADM ACADVL HADH
5 carbohydrate metabolic process GO:0005975 9.85 AKT2 FBP1 GCK IGF2 INS INSR
6 positive regulation of protein kinase B signaling GO:0051897 9.82 IGF2 INS INSR
7 positive regulation of MAPK cascade GO:0043410 9.79 IGF2 INS INSR
8 cellular response to insulin stimulus GO:0032869 9.78 AKT2 GCK INSR
9 insulin receptor signaling pathway GO:0008286 9.78 AKT2 IGF2 INS INSR
10 glycogen metabolic process GO:0005977 9.72 AGL AKT2 G6PC
11 glucose homeostasis GO:0042593 9.72 G6PC GCK INS INSR SLC16A1
12 fatty acid beta-oxidation GO:0006635 9.71 ACADL ACADM ACADVL HADH
13 positive regulation of glucose import GO:0046326 9.7 AKT2 INS INSR
14 negative regulation of insulin secretion GO:0046676 9.69 ABCC8 HADH KCNJ11
15 positive regulation of mitotic nuclear division GO:0045840 9.67 IGF2 INS INSR
16 positive regulation of glycolytic process GO:0045821 9.66 INS INSR
17 glycogen catabolic process GO:0005980 9.66 AGL G6PC
18 cellular glucose homeostasis GO:0001678 9.65 ABCC8 GCK
19 positive regulation of calcium ion import GO:0090280 9.65 CRH GCG
20 negative regulation of gluconeogenesis GO:0045721 9.64 GCK INS
21 negative regulation of fatty acid biosynthetic process GO:0045717 9.64 ACADL ACADVL
22 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.63 ACADL ACADM ACADVL
23 positive regulation of insulin receptor signaling pathway GO:0046628 9.62 IGF2 INS
24 regulation of cholesterol metabolic process GO:0090181 9.61 ACADL ACADVL
25 regulation of gluconeogenesis GO:0006111 9.6 ACADM FBP1
26 glucose 6-phosphate metabolic process GO:0051156 9.59 G6PC GCK
27 positive regulation of respiratory burst GO:0060267 9.58 INS INSR
28 negative regulation of fatty acid oxidation GO:0046322 9.57 ACADL ACADVL
29 glycogen biosynthetic process GO:0005978 9.56 ACADM AGL AKT2 GYS2
30 regulation of insulin secretion GO:0050796 9.55 ABCC8 GCG GCK KCNJ11 SLC16A1
31 carnitine metabolic process, CoA-linked GO:0019254 9.54 ACADL ACADM
32 glucose metabolic process GO:0006006 9.35 AKT2 GCK IGF2 INS KCNJ11
33 positive regulation of glycogen biosynthetic process GO:0045725 9.02 AKT2 GCK IGF2 INS INSR
34 lipid metabolic process GO:0006629 10.03 ACADL ACADM ACADVL HADH SLC16A1

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 9.58 ACADL ACADM ACADVL
2 hormone activity GO:0005179 9.56 CRH GCG IGF2 INS
3 NAD+ binding GO:0070403 9.43 GLUD1 HADH
4 ATP-activated inward rectifier potassium channel activity GO:0015272 9.37 ABCC8 KCNJ11
5 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.33 ACADL ACADM ACADVL
6 long-chain-acyl-CoA dehydrogenase activity GO:0004466 9.32 ACADL ACADVL
7 insulin-like growth factor receptor binding GO:0005159 9.13 IGF2 INS INSR
8 acyl-CoA dehydrogenase activity GO:0003995 8.8 ACADL ACADM ACADVL

Sources for Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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