MCID: HYP056
MIFTS: 67

Hypoglycemia malady

Endocrine diseases, Metabolic diseases, Rare diseases categories
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Summaries for Hypoglycemia

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MedlinePlus:33 Hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia and familial hyperinsulinism. An important gene associated with Hypoglycemia is ABCC8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8), and among its related pathways are Inwardly rectifying K+ channels and Beta oxidation of octanoyl-CoA to hexanoyl-CoA. The drugs diazoxide and glucagon and the compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and brain, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:65 Hypoglycemia (also spelled hypoglycaemia or hypoglyc more...

Aliases & Classifications for Hypoglycemia

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Hypoglycemia, Aliases & Descriptions:

Name: Hypoglycemia 8 10 44 33 62
 
Hypoglycaemia 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases, Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:9993
ICD9CM27 251.2
NCIt39 C3126
MeSH34 D007003

Related Diseases for Hypoglycemia

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Diseases in the Hypoglycemia family:

Susceptibility to Hypoglycemia Due to Glimepiride Treatment Susceptibility to Hypoglycemia Due to Gliclazide Treatment
Susceptibility to Hypoglycemia Due to Glipizide Treatment Susceptibility to Hypoglycemia Due to Glibenclamide Treatment
Susceptibility to Hypoglycemia Due to Carbutamide Treatment

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 392)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia31.9INS, ABCC8
2familial hyperinsulinism31.0HADH, ABCC8, KCNJ11, GCK
3type 1 diabetes mellitus30.9GCK, INS
4lactic acidosis30.9INS, G6PC
5growth hormone deficiency30.8CRH, INS
6insulinoma30.8ABCC8, KCNJ11, INS, G6PC, GCK
7hyperinsulinism30.6ABCC8, KCNJ11, INS, G6PC, GCK
8maturity-onset diabetes of the young30.6GCK, INS, KCNJ11
9glycogen storage disease30.5PYGL, G6PC
10hypopituitarism30.5INS, CRH
113-hydroxyacyl-coa dehydrogenase deficiency30.5HADH
12insulin resistance30.4ABCC8, INS, G6PC, GCK
13type 2 diabetes mellitus30.3GCK, G6PC, INS, KCNJ11, ABCC8
14obesity30.2ABCC8, KCNJ11, INS, CRH, GCK
15cushing's syndrome30.2INS, CRH
16neonatal diabetes mellitus30.2GCK, INS, KCNJ11, ABCC8
17galactosemia30.2SLC25A20, ACADM
18glycogen storage disease vi30.2G6PC, PYGL
19diabetes mellitus30.1ABCC8, PYGL, KCNJ11, INS, FBP1, G6PC
20gestational diabetes30.0ABCC8, KCNJ11, INS, GCK
21amenorrhea30.0CRH, INS
22glucose intolerance29.9GCK, INS
23hyperglycemia29.9ABCC8, PYGL, KCNJ11, INS, FBP1, G6PC
24hyperuricemia29.8INS, G6PC, GCK
25cystic fibrosis29.7ABCC8, KCNJ11, INS, ACADM
26fasting hypoglycemia10.7
27islet cell tumor10.7
28pancreatitis10.6
29solitary fibrous tumor10.5
30endogenous depression10.5CRH
31hemangiopericytoma10.4
32exercise-induced hyperinsulinemic hypoglycemia10.4
33hepatitis10.4
34neuronitis10.4
35leucine-sensitive hypoglycemia of infancy10.4
36insulin autoimmune syndrome10.3
37cerebritis10.3
38medium-chain acyl-coenzyme a dehydrogenase deficiency10.3ACADM, ACADL
39autonomic neuropathy10.3
40neuropathy10.3
41hyperinsulinemic hypoglycemia familial 210.3
42hyperinsulinemic hypoglycemia, familial, 110.3
43hyperinsulinemic hypoglycemia familial 310.3
44acth deficiency10.3
45congenital adrenal hyperplasia10.2ACADM, CRH
46pituitary gland disease10.2INS, CRH
47hepatocellular carcinoma10.2
48dumping syndrome10.2
49gastrointestinal stromal tumor10.2
50diabetic autonomic neuropathy10.2

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to hypoglycemia

Symptoms for Hypoglycemia

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Drugs & Therapeutics for Hypoglycemia

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Drug clinical trials:

Search ClinicalTrials for Hypoglycemia

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hypoglycemia

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Anatomical Context for Hypoglycemia

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MalaCards organs/tissues related to Hypoglycemia:

32
Liver, Testes, Brain, Kidney, Pituitary, Pancreas, Thyroid, Endothelial, Pancreatic islet, Cortex, Breast, Heart, Bone, Skeletal muscle, Lung, Hypothalamus, Spleen, Ovary, B cells, Bone marrow, Spinal cord, Colon, Uterus, Monocytes, T cells, Cingulate cortex, Parietal lobe, Adrenal cortex

Animal Models for Hypoglycemia or affiliated genes

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MGI Mouse Phenotypes related to Hypoglycemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5ABCC8, HADH, KCNJ11, INS, CRH, GCK
2MP:00053677.8ACADL, HADH, INS, G6PC, GCK, SLC22A5
3MP:00053787.6KCNJ11, G6PC, CRH, GCK, SLC22A5, INS
4MP:00053857.5ACADM, ACADL, GYS2, SLC22A5, INS, KCNJ11
5MP:00053707.5INS, SLC22A5, ACADM, GCK, ACADL, GYS2
6MP:00053766.4SLC22A5, INS, GCK, ACADM, ACADL, GYS2

Publications for Hypoglycemia

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Articles related to Hypoglycemia:

(show top 50)    (show all 1382)
idTitleAuthorsYear
1
The BARMER-Study: Impact of Standardized Warming of the Injection-site to Enhance Insulin Absorption and Reduce Prandial Insulin Requirements and Hypoglycemia in Obese Patients with Diabetes mellitus. (24392996)
2014
2
Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn. (23751383)
2013
3
Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine. (23874102)
2013
4
Medical resource use, disturbance of daily life and burden of hypoglycemia in insulin-treated patients with diabetes: results from a European online survey. (23402452)
2013
5
Diffusion-weighted imaging changes caused by acute hypoglycemia and prolonged febrile convulsion in childhood. (23471020)
2013
6
The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. (24212718)
2013
7
Engineering a control system for hypoglycemia prevention, detection, and intervention in critical care*. (24096688)
2013
8
Anti-insulin receptor antibodies related to hypoglycemia in a previously diabetic patient. (23704685)
2013
9
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
10
Insulin pumps with a sensor and threshold-suspend reduced nocturnal hypoglycemia in type 1 diabetes. (24042390)
2013
11
New insights and new conundrums in neonatal hypoglycemia: enigmas wrapped in mystery. (23613554)
2013
12
A 10-s sprint performed after moderate-intensity exercise neither increases nor decreases the glucose requirement to prevent late-onset hypoglycemia in individuals with type 1 diabetes. (24130362)
2013
13
Avoiding hypoglycemia at all costs is crucial for some with diabetes. (23800913)
2013
14
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
15
Prevention of hypoglycemia-induced neuronal death by minocycline. (22998689)
2012
16
Risk of postoperative hypoglycemia in cardiovascular surgical patients receiving computer-based versus paper-based insulin therapy. (22440994)
2012
17
Comment on: Holstein et al. Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a german longitudinal population-based study. Diabetes Care 2012;35:972-975. (23173147)
2012
18
The importance of hypoglycemia in diabetic patients. (23497433)
2012
19
Hypoglycemia associated with the use of levofloxacin. (19451612)
2009
20
Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes: findings from the Turkish cohort of the PREDICTIVE observational study. (19220776)
2009
21
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
22
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
23
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. (18471680)
2008
24
Severe hypoglycemia in a patient with anorexia nervosa. (18319628)
2008
25
Re: "Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome". (17171485)
2007
26
Prolactin and growth hormone responses to hypoglycemia in patients with systemic sclerosis and psoriatic arthritis. (16855141)
2006
27
Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73. (17070446)
2006
28
Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. (15855577)
2005
29
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. (15161766)
2004
30
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma. (15223980)
2004
31
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
32
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
33
Paraneoplastic hypoglycemia in localized fibrous tumors of the pleura]. (11195068)
2000
34
5-HT3 serotonergic receptor mediation of hypoglycemia-induced arginine-vasopressin but not oxytocin secretion in normal men. (9633016)
1998
35
Pancreatic alpha-cell function in idiopathic reactive hypoglycemia. (9186298)
1997
36
Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. (9113474)
1997
37
Insulinlike growth factor binding proteins and tumor hypoglycemia. (18406681)
1995
38
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
39
The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. (8425662)
1993
40
Serum estradiol but not gonadotropin levels decrease acutely after insulin-induced hypoglycemia in cycling women. (1400870)
1992
41
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans. (1592870)
1992
42
Prevalence and consequences of nocturnal hypoglycemia among conventionally treated children with diabetes mellitus. (2184211)
1990
43
Changes in the secretion of the hormones of the hypothalamo-hypophyseo-adrenal system in Itsenko-Cushing disease under the influence of insulin-induced hypoglycemia and thyroliberin]. (2164280)
1990
44
The catecholamine response to hypoglycemia in children with isolated growth hormone deficiency syndromes and multiple pituitary hormone defects. (3540823)
1986
45
Isolated ACTH deficiency contributing to frequent hypoglycemia in type I diabetes. (2988889)
1985
46
Hypoglycemia secondary to factitious hyperinsulinism. (7005884)
1981
47
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
48
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. (4358644)
1974
49
Islet cell tumor with hypoglycemia. (4323689)
1971
50
Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides. (4320761)
1970

Variations for Hypoglycemia

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Expression for genes affiliated with Hypoglycemia

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Expression patterns in normal tissues for genes affiliated with Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for genes affiliated with Hypoglycemia

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Pathways related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0KCNJ11, ABCC8
2
Show member pathways
9.8ACADM, HADH
3
Show member pathways
9.7GCK, INS
49.6GYS2, KCNJ11, ABCC8
59.5GYS2, PYGL
6
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.5HADH, ACADM, ACADL
79.5GCK, G6PC, ACADM
8
Show member pathways
9.4KCNJ11, ABCC8, INS
9
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.4GCK, FBP1, ACADM
10
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.3FBP1, G6PC, GCK
11
Show member pathways
9.2INS, GCK, KCNJ11, ABCC8
12
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
13
Show member pathways
9.0HADH, ACADL, ACADM, SLC25A20
14
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)37
Fatty Acid Beta Oxidation37
9.0ACADL, HADH, ACADM, SLC25A20
15
Show member pathways
malate-aspartate shuttle37
glycogen biosynthesis II (from UDP-D-Glucose)37
9.0GYS2, PYGL, FBP1
16
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I37
galactose degradation I (Leloir pathway)37
Cori Cycle37
8.9G6PC, GCK, GYS2, PYGL
17
Show member pathways
8.9PYGL, GCK, G6PC, GYS2
18
Show member pathways
8.7GCK, SLC22A5, ABCC8, G6PC
19
Show member pathways
8.3GCK, G6PC, GYS2, PYGL, FBP1
208.2GCK, ACADM, G6PC, INS, KCNJ11, ABCC8
21
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
7.8GCK, FBP1, GYS2, PYGL, INS, G6PC
22
Show member pathways
5.9ACADL, SLC25A20, GCK, ACADM, GYS2, G6PC

Compounds for genes affiliated with Hypoglycemia

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Compounds related to Hypoglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cibenzoline4410.4KCNJ11, ABCC8
2nicorandil44 2811.3ABCC8, KCNJ11
3mgadp4410.3ABCC8, KCNJ11
4cromakalim44 2811.2ABCC8, KCNJ11
5meglitinide4410.1ABCC8, INS
6mitiglinide44 1111.1ABCC8, INS
7Tetradecanoyl-CoA2410.1ACADM, ACADL
8chromium picolinate4410.1GCK, INS
9glipizide44 50 1112.0INS, ABCC8
10preproinsulin4410.0GCK, INS
11FADH2410.0ACADM, ACADL
12chlorpropamide44 50 1112.0ABCC8, INS
13i-app449.9INS, GCK
14repaglinide50 44 1111.9KCNJ11, ABCC8, INS
15gliclazide44 50 1111.9KCNJ11, INS, ABCC8
16glimepiride44 50 1111.8INS, KCNJ11, ABCC8
17pristanic acid44 28 2411.8ACADL, SLC25A20
18c-peptide449.8GCK, KCNJ11, INS
19Heptanoyl-CoA249.8ACADM, ACADL, HADH
20amylose44 2410.7GYS2, PYGL
21fructose-6-phosphate44 1110.7GCK, G6PC, FBP1
22aicar44 24 1111.7G6PC, GCK, INS
23minoxidil44 28 1111.7ABCC8, KCNJ11
24streptozotocin449.7G6PC, GCK, INS
252-deoxyglucose44 1110.6G6PC, GCK, INS
26sulfonylurea449.6INS, ABCC8, KCNJ11, GCK
27tolbutamide44 28 50 1112.6GCK, INS, ABCC8, KCNJ11
28metformin44 50 1111.6ABCC8, KCNJ11, INS, GCK
29incretin449.6GCK, INS
30dhea449.6CRH, INS, G6PC
31glibenclamide44 28 50 6112.6KCNJ11, INS, CRH, ABCC8
32beta-hydroxybutyrate449.5INS, G6PC
33acyl-coa449.4SLC25A20, HADH, ACADL, ACADM
34leucine449.4HADH, G6PC, KCNJ11, ABCC8, GCK
35moxonidine449.4INS, SLC22A5
36glycerol44 24 1111.4G6PC, INS, CRH, GCK
37glutamine449.4KCNJ11, GCK, ACADM, G6PC
38mepyramine44 1110.4CRH, SLC22A5
39katp449.3GCK, INS, KCNJ11, ABCC8, HADH
40diazoxide44 61 28 1112.3GCK, INS, HADH, ABCC8, KCNJ11
41glucose 6-phosphate44 2410.3PYGL, GYS2, GCK, G6PC
42verapamil44 28 50 24 1113.2KCNJ11, CRH, SLC22A5
43lactate449.0INS, GCK, ACADM, G6PC
44glycogen44 249.5G6PC, ABCC8, PYGL, INS, GYS2, GCK
45glutamate448.3G6PC, ABCC8, KCNJ11, INS, CRH, GCK
46lipid448.3G6PC, SLC25A20, GCK, ACADM, INS, ABCC8
47carnitine448.1HADH, ACADM, INS, SLC25A20, ACADL, SLC22A5
48fatty acid448.0ABCC8, HADH, ACADL, ACADM, INS, SLC25A20
49arginine447.3SLC22A5, GCK, CRH, ACADM, INS, KCNJ11
50glucose446.7SLC25A20, GYS2, GCK, ACADM, G6PC, FBP1

GO Terms for genes affiliated with Hypoglycemia

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Cellular components related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057599.5ACADM, ACADL, HADH
2mitochondrionGO:0057398.2SLC25A20, GCK, ACADM, ACADL, KCNJ11, HADH

Biological processes related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epinephrine secretionGO:03281110.2CRH, GCK
2carnitine metabolic process, CoA-linkedGO:01925410.1ACADM, ACADL
3fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.0ACADL, ACADM
4negative regulation of insulin secretionGO:04667610.0HADH, KCNJ11
5negative regulation of gluconeogenesisGO:04572110.0INS, GCK
6positive regulation of glycolytic processGO:0458219.9GCK, INS
7positive regulation of glycogen biosynthetic processGO:0457259.9INS, GCK
8glycogen biosynthetic processGO:0059789.9GYS2, ACADM, GCK
9regulation of gluconeogenesisGO:0061119.9FBP1, ACADM
10fatty acid beta-oxidationGO:0066359.8HADH, ACADL, ACADM
11hexose transportGO:0086459.7G6PC, GCK
12endocrine pancreas developmentGO:0310189.7GCK, INS
13energy reserve metabolic processGO:0061129.7INS, KCNJ11, ABCC8
14response to drugGO:0424939.6CRH, KCNJ11, HADH
15glycogen catabolic processGO:0059809.6G6PC, PYGL
16glucose transportGO:0157589.6GCK, G6PC, INS
17regulation of insulin secretionGO:0507969.5ABCC8, KCNJ11, INS, GCK
18glycogen metabolic processGO:0059779.5PYGL, G6PC
19cellular lipid metabolic processGO:0442559.3SLC25A20, ACADM, ACADL, HADH
20gluconeogenesisGO:0060949.2G6PC, FBP1
21glucose homeostasisGO:0425939.0PYGL, INS, G6PC, GCK
22transmembrane transportGO:0550858.9SLC22A5, GCK, G6PC, ABCC8
23glucose metabolic processGO:0060068.6PYGL, KCNJ11, INS, FBP1, GYS2
24carbohydrate metabolic processGO:0059758.5ABCC8, PYGL, FBP1, G6PC, GYS2, GCK
25small molecule metabolic processGO:0442816.2SLC25A20, HADH, ABCC8, PYGL, KCNJ11, INS

Molecular functions related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose bindingGO:0055369.6GCK, PYGL
2acyl-CoA dehydrogenase activityGO:0039959.5ACADL, ACADM
3AMP bindingGO:0162089.2PYGL, FBP1
4ATP bindingGO:0055248.3SLC22A5, GCK, KCNJ11, PYGL, ABCC8

Products for genes affiliated with Hypoglycemia

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Sources for Hypoglycemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet