MCID: HYP056
MIFTS: 62

Hypoglycemia

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Hypoglycemia

Summaries for Hypoglycemia

MedlinePlus : 40 Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 2, and has symptoms including sugar craving An important gene associated with Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Heparin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and brain, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 72 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 3 34.3 ABCC8 GCK
2 hyperinsulinemic hypoglycemia, familial, 2 34.2 ABCC8 INS KCNJ11
3 hyperinsulinemic hypoglycemia, familial, 5 34.2 ABCC8 INSR
4 hyperinsulinemic hypoglycemia, familial, 4 34.2 ABCC8 HADH
5 hyperinsulinemic hypoglycemia 33.2 ABCC8 GCK GLUD1 HADH INS INSR
6 insulin autoimmune syndrome 33.1 INS INSR
7 fasting hypoglycemia 32.6 ACADM CRH GLUD1 GYS2 INSR
8 carnitine-acylcarnitine translocase deficiency 32.1 CPT1A SLC25A20
9 glycogen storage disease type 0 31.8 AGL GYS2
10 carnitine palmitoyltransferase ii deficiency, infantile 31.8 ACADL ACADVL CPT1A SLC25A20
11 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 31.7 ABCC8 KCNJ11
12 fructose-1,6-bisphosphatase deficiency 31.6 AGL FBP1 G6PC GCG
13 glycogen storage disease iii 31.3 AGL G6PC GCG
14 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 31.0 ACADM ACADVL HADH
15 acyl-coa dehydrogenase, medium-chain, deficiency of 30.8 ACADL ACADM ACADVL
16 acyl-coa dehydrogenase, very long-chain, deficiency of 30.8 ACADL ACADVL HADH SLC25A20
17 insulinoma 30.8 ABCC8 GCG GCK INS
18 3-hydroxyacyl-coa dehydrogenase deficiency 30.1 ACADM ACADVL GCK GLUD1 HADH INS
19 hyperinsulinism 30.0 ABCC8 GCK GLUD1 HADH INS INSR
20 diabetes mellitus 30.0 ABCC8 AKT2 GCG GCK INS INSR
21 insulin-like growth factor i 29.9 AKT2 INS INSR
22 maturity-onset diabetes of the young 29.9 ABCC8 GCG GCK INS KCNJ11
23 hyperglycemia 29.9 ABCC8 G6PC GCG GCK INS INSR
24 gestational diabetes 29.7 GCK INS INSR KCNJ11
25 monogenic diabetes 29.6 ABCC8 GCK INS KCNJ11
26 glycogen storage disease 29.4 AGL G6PC GYS2
27 glucose intolerance 29.4 GCG GCK INS INSR
28 body mass index quantitative trait locus 11 28.9 CPT1A CRH GCG GCK INS INSR
29 diabetes mellitus, noninsulin-dependent 28.3 ABCC8 AKT2 G6PC GCG GCK INS
30 hyperinsulinemic hypoglycemia, familial, 1 12.5
31 hypoglycemia, leucine-induced 12.4
32 hyperinsulinemic hypoglycemia, familial, 7 12.3
33 hyperinsulinemic hypoglycemia, familial, 6 12.3
34 hypoinsulinemic hypoglycemia with hemihypertrophy 12.2
35 hypoketonemic hypoglycemia 11.9
36 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 11.8
37 glycogen storage disease 0, liver 11.8
38 glycogen storage disease ia 11.2
39 beckwith-wiedemann syndrome 11.1
40 carbonic anhydrase va deficiency, hyperammonemia due to 11.1
41 phosphoenolpyruvate carboxykinase deficiency, cytosolic 11.1
42 fructose intolerance, hereditary 11.0
43 carnitine palmitoyltransferase i deficiency 11.0
44 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 11.0
45 mitochondrial dna depletion syndrome 4a 11.0
46 galactosemia 11.0
47 achalasia-addisonianism-alacrima syndrome 11.0
48 congenital disorder of glycosylation, type in 11.0
49 mitochondrial complex iii deficiency 11.0
50 pepck 1 deficiency 11.0

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:


sugar craving

MGI Mouse Phenotypes related to Hypoglycemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 INSR KCNJ11 SLC16A1 SLC25A20 INS CPT1A
2 endocrine/exocrine gland MP:0005379 10.07 INSR KCNJ11 SLC25A20 AKT2 INS ABCC8
3 liver/biliary system MP:0005370 10.07 INSR SLC16A1 SLC25A20 INS CRH ACADL
4 adipose tissue MP:0005375 10.01 INSR KCNJ11 SLC16A1 AKT2 INS CRH
5 mortality/aging MP:0010768 9.97 SLC25A20 INS INSR KCNJ11 SLC16A1 AKT2
6 muscle MP:0005369 9.56 INSR KCNJ11 AKT2 INS ACADM ACADVL
7 renal/urinary system MP:0005367 9.23 INSR SLC25A20 HADH INS CRH ACADL

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 472)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
2
Glyburide Approved Phase 4,Phase 2,Phase 3,Phase 1 10238-21-8 3488
3
Ezetimibe Approved Phase 4 163222-33-1 150311
4
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
5
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
6
Diazoxide Approved Phase 4,Phase 2,Phase 3,Phase 1 364-98-7 3019
7
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
8
Glipizide Approved, Investigational Phase 4,Phase 3 29094-61-9 3478
9
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1 93479-97-1 3476
10
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 4091 14219
11
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 6400441 383414
12
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 657311 5754
13
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 2 56180-94-0 441184
14 lanreotide Approved Phase 4 108736-35-2
15
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 141758-74-9 15991534
16
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
17
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
18
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1 204656-20-2 44147092
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
20
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
21
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
22
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
23
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
24
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
25
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
26
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
27
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
28
Ethanol Approved Phase 4,Phase 2,Phase 1 64-17-5 702
29
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
30
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
31
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
32
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 51-43-4 5816
33
Gliclazide Approved Phase 4,Phase 3,Phase 2 21187-98-4 3475
34
Doxazosin Approved Phase 4 74191-85-8 3157
35
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
36
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2 151126-32-8
37
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
38
Phenoxybenzamine Approved Phase 4 59-96-1 4768
39
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
40
Fosaprepitant Approved Phase 4 172673-20-0 219090
41
Gliquidone Approved, Investigational Phase 4 33342-05-1 91610
42
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
43
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
44
Linagliptin Approved Phase 4,Phase 3 668270-12-0 10096344
45 Racepinephrine Approved Phase 4,Phase 2,Early Phase 1 329-65-7
46
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
47
Protein C Approved Phase 4,Phase 2
48
Verapamil Approved Phase 4 52-53-9 2520
49
Memantine Approved, Investigational Phase 4 19982-08-2 4054
50 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1717)

# Name Status NCT ID Phase Drugs
1 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4 Lactate;Glucose
2 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
3 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
4 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
5 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
6 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
7 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
8 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
9 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
10 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
11 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
12 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
13 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
14 Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients Unknown status NCT02462369 Phase 4 Saxagliptin;glimepiride
15 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Unknown status NCT02624830 Phase 4 Sulfonylurea
16 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
17 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
18 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
19 Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes Unknown status NCT02449603 Phase 4 Exenatide;Biphasic insulin Aspart 30
20 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
21 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
22 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
23 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4 Galvus (vildagliptin);pioglitazone
24 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
25 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
26 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
27 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Unknown status NCT02517242 Phase 4
28 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
29 Randomized Trial Comparing Colesevelam vs. Ezetimibe Unknown status NCT02682680 Phase 4 Colesevelam;Ezetimibe
30 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4 Transient Continuous Subcutaneous Insulin Infusion;Transient Multiple Daily Insulin Injections
31 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4 Switching to NPH insulin;Continuation of insulin glargine
32 Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
33 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4 Lixisenatide
34 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4 Vildagliptin
35 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
36 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
37 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4 Vildagliptin
38 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4 Human insulin;Human Insulin
39 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
40 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
41 Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial) Completed NCT00390728 Phase 4 Insulin Glargine
42 Phase 4 Study in the Elderly Patients With T2DM Completed NCT01238978 Phase 4 Vildagliptin;"Usual Care"
43 Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 in Type 2 Diabetes Completed NCT01487798 Phase 4 biphasic human insulin 30;biphasic insulin aspart 30
44 Sitagliptin and Glucagon Counterregulation Completed NCT02256189 Phase 4 Sitagliptin;Placebo
45 The Incidence of Hypoglycemia in Insulin Glargine-Treated Subjects With Diabetes Mellitus Upon Switching Between Bedtime and Morning Dosing Completed NCT00609895 Phase 4 INSULIN GLARGINE
46 The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass Surgery Completed NCT02336438 Phase 4
47 Glucagon Efficiency After High and Low Carbohydrate Diet Completed NCT02578498 Phase 4
48 The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Completed NCT02881060 Phase 4
49 Efficacy and Safety of Insulin Aspart vs. Human Insulin During Pregnancy by Women With Type 1 Diabetes Completed NCT00365170 Phase 4 human insulin;insulin aspart
50 Lantus Versus Levemir Treat-To-Target Completed NCT00405418 Phase 4 Insulin glargine;Insulin Detemir

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

# Genetic test Affiliating Genes
1 Hypoglycemia 28

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

38
Pancreas, Testes, Brain, Liver, Kidney, Heart, Pancreatic Islet

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 1650)
# Title Authors Year
1
Second-Generation Antipsychotic-Induced Hypoglycemia. ( 29372938 )
2018
2
Overnight Glucose Control with Dual- and Single-Hormone Artificial Pancreas in Type 1 Diabetes with Hypoglycemia Unawareness: A Randomized Controlled Trial. ( 29393675 )
2018
3
Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows. ( 29428744 )
2018
4
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. ( 29139589 )
2018
5
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. ( 29381484 )
2018
6
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
7
Costello Syndrome: The Challenge of Hypoglycemia and Failure to Thrive. ( 29248509 )
2018
8
A case of CHARGE syndrome associated with hyperinsulinemic hypoglycemia in infancy. ( 29355723 )
2018
9
Roux en Y gastric bypass hypoglycemia resolves with gastric feeding or reversal: Confirming a non-pancreatic etiology. ( 29449181 )
2018
10
Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes? ( 29411343 )
2018
11
An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study. ( 29433560 )
2018
12
Insulin Detemir Use Is Associated With Higher Occurrence of Hypoglycemia in Hospitalized Patients With Hypoalbuminemia. ( 29437697 )
2018
13
A Quality-Improvement Initiative to Reduce NICU Transfers for Neonates at Risk for Hypoglycemia. ( 29437908 )
2018
14
Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue. ( 29415555 )
2018
15
Can reversal of RYGB also reverse hypoglycemia? ( 29371089 )
2018
16
Relationship between Blood Glucose Fluctuation and Brain Damage in the Hypoglycemia Neonates. ( 29444533 )
2018
17
Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus. ( 29451006 )
2018
18
Neonatal hypoglycemia, early-onset diabetes and hypopituitarism due to the mutation in EIF2S3 gene causing MEHMO syndrome. ( 29303605 )
2018
19
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
20
Intentional overdose of liraglutide in a non-diabetic patient causing severe hypoglycemia. ( 29397808 )
2018
21
Severe insulin resistance in disguise: A familial case of reactive hypoglycemia associated with a novel heterozygous INSR mutation. ( 29411486 )
2018
22
Prolonged Severe Hypoglycemia in a Pediatric Patient With Type 1 Diabetes. ( 29382986 )
2018
23
Hypoglycemia in Diabetes Mellitus. ( 28857877 )
2017
24
Dipyrone in association with atropine inhibits the effect on gastric emptying induced by hypoglycemia in rats. ( 28876363 )
2017
25
A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. ( 29087246 )
2017
26
Factors Affecting the Ability of People With Diabetes to Avoid Hypoglycemia. ( 28079649 )
2017
27
50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey. ( 28010803 )
2017
28
Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. ( 28928117 )
2017
29
Postprandial hyperinsulinemic hypoglycemia in a child as a late complication of esophageal reconstruction. ( 28672750 )
2017
30
Selective Arterial Calcium Stimulation with Hepatic Venous Sampling in Patients with Recurrent Endogenous Hyperinsulinemic Hypoglycemia and Metastatic Insulinoma: Evaluation in Five Patients. ( 29157479 )
2017
31
Conditional Tissue-Specific Foxa2 Ablation in Mouse Pancreas Causes Hyperinsulinemic Hypoglycemia: RETRACTED. ( 28288081 )
2017
32
Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia. ( 28235848 )
2017
33
Tramadol-induced hypoglycemia: An unusual adverse effect. ( 29416258 )
2017
34
Letter to the Editor: Intranasal Glucagon for Hypoglycemia. ( 28091864 )
2017
35
Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann, Sotos, and Kabuki syndromes: A nationwide survey in Japan. ( 28102591 )
2017
36
Hypothalamic Glucose Transport in Humans During Experimentally Induced Hypoglycemia-Associated Autonomic Failure. ( 28911152 )
2017
37
Fasting Hypoglycemia on (18)F-FDG PET/CT Scan. ( 28420855 )
2017
38
Hypoglycemia awareness among insulin-treated patients with diabetes in Malaysia: A cohort subanalysis of the HAT study. ( 28888148 )
2017
39
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. ( 28887311 )
2017
40
UQCRC2 mutation in a patient with mitochondrial complex III deficiency causing recurrent liver failure, lactic acidosis and hypoglycemia. ( 28275242 )
2017
41
Rare Cause of Recurrent Hypoglycemia: Insulin Autoimmune Syndrome. ( 29318060 )
2017
42
Levels of glucose-regulatory hormones in patients with non-islet cell tumor hypoglycemia: including a review of the literature. ( 28529277 )
2017
43
Hypoglycemia and severe lactic acidosis in a dog following metformin exposure. ( 29225865 )
2017
44
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction. ( 28216384 )
2017
45
Postprandial hypoglycemia as the only manifestation of insulinoma: exceptional case report. ( 28416239 )
2017
46
Central Congenital Hypoventilation Syndrome associated with hypoglycemia and seizure. ( 28070480 )
2017
47
Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population. ( 28913363 )
2017
48
Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia. ( 28715810 )
2017
49
Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma. ( 28785493 )
2017
50
Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes. ( 29264578 )
2017

Variations for Hypoglycemia

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for Hypoglycemia

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 ABCC8 ACADL ACADM ACADVL AGL CPT1A
2
Show member pathways
12.85 AKT2 FBP1 G6PC GCK GYS2 INS
3
Show member pathways
12.84 ACADL ACADM ACADVL CPT1A HADH SLC25A20
4
Show member pathways
12.81 AGL FBP1 G6PC GCK GYS2
5
Show member pathways
12.7 ABCC8 AKT2 GCG GCK INS KCNJ11
6
Show member pathways
12.59 AGL FBP1 G6PC GCK GYS2
7 12.46 AKT2 CPT1A FBP1 GCG GLUD1 INS
8
Show member pathways
12.45 AKT2 FBP1 G6PC GYS2 INS INSR
9
Show member pathways
12.36 AKT2 CPT1A FBP1 G6PC GYS2 INS
10
Show member pathways
12.3 ABCC8 GCG INS KCNJ11
11
Show member pathways
12.24 ACADM FBP1 GCK GLUD1
12
Show member pathways
12.14 AKT2 CPT1A GYS2 INS INSR
13 12.11 ACADM CPT1A G6PC GCK
14
Show member pathways
12.02 AKT2 G6PC INS INSR
15
Show member pathways
11.95 AGL G6PC GCK GYS2
16 11.9 AKT2 G6PC INSR
17
Show member pathways
11.86 ABCC8 GCK INS INSR KCNJ11
18
Show member pathways
11.84 AKT2 CPT1A G6PC GYS2 INS INSR
19 11.83 AKT2 INS INSR
20
Show member pathways
11.83 AKT2 GCK INS
21
Show member pathways
11.82 ACADL ACADM ACADVL CPT1A HADH
22 11.78 ACADM GLUD1 HADH
23 11.66 ACADL ACADM CPT1A
24 11.64 AKT2 CPT1A G6PC
25
Show member pathways
11.64 ACADL ACADM ACADVL HADH
26 11.51 AKT2 INS INSR
27 11.51 AKT2 CPT1A FBP1 G6PC GCG GCK
28 11.48 ABCC8 AKT2 CPT1A GYS2 KCNJ11
29 11.39 AKT2 INS INSR
30
Show member pathways
11.36 ACADL ACADM ACADVL CPT1A HADH SLC25A20
31 11.2 AKT2 INS INSR
32 10.92 ABCC8 ACADM ACADVL CPT1A G6PC GCK
33
Show member pathways
10.86 AKT2 INSR
34 10.68 CPT1A SLC25A20
35
Show member pathways
10.63 ACADM HADH

GO Terms for Hypoglycemia

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 9.55 ACADL ACADM ACADVL GLUD1 HADH
2 secretory granule lumen GO:0034774 9.43 AGL GCG INS
3 mitochondrion GO:0005739 9.36 ABCC8 ACADL ACADM ACADVL CPT1A GCK
4 inward rectifying potassium channel GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 ABCC8 CPT1A CRH HADH KCNJ11
2 metabolic process GO:0008152 9.95 ACADL ACADM ACADVL AGL FBP1 GCK
3 carbohydrate metabolic process GO:0005975 9.88 AKT2 FBP1 GCK INS INSR
4 fatty acid metabolic process GO:0006631 9.83 ACADL ACADM ACADVL CPT1A HADH
5 cellular response to insulin stimulus GO:0032869 9.81 AKT2 GCK INSR
6 insulin receptor signaling pathway GO:0008286 9.8 AKT2 INS INSR
7 glucose homeostasis GO:0042593 9.77 G6PC GCK INS INSR SLC16A1
8 glycogen metabolic process GO:0005977 9.72 AGL AKT2 G6PC
9 positive regulation of glucose import GO:0046326 9.69 AKT2 INS INSR
10 negative regulation of insulin secretion GO:0046676 9.67 ABCC8 HADH KCNJ11
11 adrenal gland development GO:0030325 9.66 CRH INSR
12 positive regulation of glycolytic process GO:0045821 9.66 INS INSR
13 glycogen catabolic process GO:0005980 9.65 AGL G6PC
14 cellular glucose homeostasis GO:0001678 9.65 ABCC8 GCK
15 positive regulation of calcium ion import GO:0090280 9.65 CRH GCG
16 glucose metabolic process GO:0006006 9.65 AKT2 CPT1A GCK INS KCNJ11
17 negative regulation of fatty acid biosynthetic process GO:0045717 9.64 ACADL ACADVL
18 negative regulation of gluconeogenesis GO:0045721 9.64 GCK INS
19 regulation of cholesterol metabolic process GO:0090181 9.63 ACADL ACADVL
20 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.63 ACADL ACADM ACADVL
21 carnitine shuttle GO:0006853 9.62 CPT1A SLC25A20
22 glycogen biosynthetic process GO:0005978 9.62 ACADM AGL AKT2 GYS2
23 regulation of gluconeogenesis GO:0006111 9.61 ACADM FBP1
24 glucose 6-phosphate metabolic process GO:0051156 9.61 G6PC GCK
25 positive regulation of fatty acid beta-oxidation GO:0032000 9.6 AKT2 CPT1A
26 carnitine metabolic process GO:0009437 9.59 ACADM CPT1A
27 positive regulation of respiratory burst GO:0060267 9.58 INS INSR
28 neuron projection maintenance GO:1990535 9.58 INS INSR
29 negative regulation of fatty acid oxidation GO:0046322 9.57 ACADL ACADVL
30 carnitine metabolic process, CoA-linked GO:0019254 9.52 ACADL ACADM
31 positive regulation of glycogen biosynthetic process GO:0045725 9.46 AKT2 GCK INS INSR
32 fatty acid beta-oxidation GO:0006635 9.35 ACADL ACADM ACADVL CPT1A HADH
33 regulation of insulin secretion GO:0050796 9.1 ABCC8 CPT1A GCG GCK KCNJ11 SLC16A1
34 lipid metabolic process GO:0006629 10.01 ACADL ACADM ACADVL CPT1A HADH SLC16A1

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.85 ACADL ACADM ACADVL GLUD1 HADH
2 hormone activity GO:0005179 9.61 CRH GCG INS
3 flavin adenine dinucleotide binding GO:0050660 9.5 ACADL ACADM ACADVL
4 insulin-like growth factor receptor binding GO:0005159 9.4 INS INSR
5 NAD+ binding GO:0070403 9.37 GLUD1 HADH
6 ATP-activated inward rectifier potassium channel activity GO:0015272 9.26 ABCC8 KCNJ11
7 long-chain-acyl-CoA dehydrogenase activity GO:0004466 9.16 ACADL ACADVL
8 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.13 ACADL ACADM ACADVL
9 acyl-CoA dehydrogenase activity GO:0003995 8.8 ACADL ACADM ACADVL

Sources for Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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