MCID: HYP056
MIFTS: 63

Hypoglycemia malady

Endocrine diseases category
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Summaries for Hypoglycemia

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34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia and insulinoma. An important gene associated with Hypoglycemia is ABCC8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8), and among its related pathways are Inwardly rectifying K+ channels and Beta oxidation of octanoyl-CoA to hexanoyl-CoA. The drugs diazoxide and glucagon and the compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:65 Hypoglycemia (also spelled hypoglycaemia or hypoglyc more...

Aliases & Classifications for Hypoglycemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypoglycemia 8 10 45 34 62
hypoglycaemia 8


External Ids:

Disease Ontology8 DOID:9993
MeSH35 D007003
ICD9CM27 251.2
NCIt40 C3126

Related Diseases for Hypoglycemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 379)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia31.5INS, ABCC8
2insulinoma30.8ABCC8, KCNJ11, INS, G6PC, GCK
3diabetes mellitus30.8ABCC8, PYGL, KCNJ11, INS, FBP1, G6PC
4type 1 diabetes mellitus30.7GCK, INS
5hyperinsulinism30.7ABCC8, KCNJ11, INS, G6PC, GCK
6familial hyperinsulinism30.7HADH, ABCC8, KCNJ11, GCK
7lactic acidosis30.7INS, G6PC
8growth hormone deficiency30.6CRH, INS
9hyperglycemia30.5ABCC8, PYGL, KCNJ11, INS, FBP1, G6PC
10glycogen storage disease30.4PYGL, G6PC
11insulin resistance30.4ABCC8, INS, G6PC, GCK
12type 2 diabetes mellitus30.4GCK, G6PC, INS, KCNJ11, ABCC8
13maturity-onset diabetes of the young30.3GCK, INS, KCNJ11
14obesity30.3ABCC8, KCNJ11, INS, CRH, GCK
15hypopituitarism30.3INS, CRH
16galactosemia30.2SLC25A20, ACADM
17cushing's syndrome30.0INS, CRH
18glycogen storage disease vi30.0G6PC, PYGL
19gestational diabetes29.9ABCC8, KCNJ11, INS, GCK
203-hydroxyacyl-coa dehydrogenase deficiency29.9HADH
21neonatal diabetes mellitus29.8GCK, INS, KCNJ11, ABCC8
22amenorrhea29.8CRH, INS
23glucose intolerance29.7GCK, INS
24hyperuricemia29.7INS, G6PC, GCK
25cystic fibrosis29.7ABCC8, KCNJ11, INS, ACADM
26fasting hypoglycemia10.7
27islet cell tumor10.7
28pancreatitis10.6
29solitary fibrous tumor10.5
30hemangiopericytoma10.4
31exercise-induced hyperinsulinemic hypoglycemia10.4
32hepatitis10.3
33neuronitis10.3
34leucine-sensitive hypoglycemia of infancy10.3
35insulin autoimmune syndrome10.3
36cerebritis10.3
37autonomic neuropathy10.3
38neuropathy10.3
39hyperinsulinemic hypoglycemia familial 210.3
40hyperinsulinemic hypoglycemia, familial, 110.3
41hyperinsulinemic hypoglycemia familial 310.2
42acth deficiency10.2
43diabetic autonomic neuropathy10.2
44dumping syndrome10.2
45hepatocellular carcinoma10.2
46thyroiditis10.2
47endotheliitis10.2
48gastrointestinal stromal tumor10.2
49ischemia10.2
50hypoxia10.2

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to hypoglycemia

Symptoms for Hypoglycemia

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Drugs & Therapeutics for Hypoglycemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hypoglycemia

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hypoglycemia

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Anatomical Context for Hypoglycemia

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33MalaCards
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MalaCards organs/tissues related to Hypoglycemia:

33
Liver, Testes, Kidney, Brain, Pituitary, Pancreas, Pancreatic islet, Endothelial, Thyroid, Breast, Cortex, Heart, Bone, Lung, Skeletal muscle, Hypothalamus, Spleen, Ovary, B cells, Adrenal cortex, Cingulate cortex, Spinal cord, Uterus, T cells, Monocytes, Colon, Bone marrow, Parietal lobe

Animal Models for Hypoglycemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypoglycemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5HADH, ABCC8, KCNJ11, INS, CRH, GCK
2MP:00053677.8HADH, INS, G6PC, ACADL, GCK, SLC22A5
3MP:00053787.6KCNJ11, INS, G6PC, CRH, GCK, SLC22A5
4MP:00053857.5KCNJ11, INS, GYS2, ACADL, ACADM, SLC22A5
5MP:00053707.5INS, G6PC, GYS2, ACADL, ACADM, GCK
6MP:00053766.4SLC22A5, HADH, ABCC8, KCNJ11, INS, G6PC

Publications for Hypoglycemia

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Sources:
52PubMed
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Articles related to Hypoglycemia:

(show top 50)    (show all 1333)
idTitleAuthorsYear
1
The BARMER-Study: Impact of Standardized Warming of the Injection-site to Enhance Insulin Absorption and Reduce Prandial Insulin Requirements and Hypoglycemia in Obese Patients with Diabetes mellitus. (24392996)
2014
2
Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn. (23751383)
2013
3
Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine. (23874102)
2013
4
Medical resource use, disturbance of daily life and burden of hypoglycemia in insulin-treated patients with diabetes: results from a European online survey. (23402452)
2013
5
Diffusion-weighted imaging changes caused by acute hypoglycemia and prolonged febrile convulsion in childhood. (23471020)
2013
6
Impact of hypoglycemia in hospitalized patients. (23065370)
2013
7
The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. (24212718)
2013
8
Engineering a control system for hypoglycemia prevention, detection, and intervention in critical care*. (24096688)
2013
9
Anti-insulin receptor antibodies related to hypoglycemia in a previously diabetic patient. (23704685)
2013
10
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
11
Insulin pumps with a sensor and threshold-suspend reduced nocturnal hypoglycemia in type 1 diabetes. (24042390)
2013
12
New insights and new conundrums in neonatal hypoglycemia: enigmas wrapped in mystery. (23613554)
2013
13
A 10-s sprint performed after moderate-intensity exercise neither increases nor decreases the glucose requirement to prevent late-onset hypoglycemia in individuals with type 1 diabetes. (24130362)
2013
14
Avoiding hypoglycemia at all costs is crucial for some with diabetes. (23800913)
2013
15
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
16
Prevention of hypoglycemia-induced neuronal death by minocycline. (22998689)
2012
17
Risk of postoperative hypoglycemia in cardiovascular surgical patients receiving computer-based versus paper-based insulin therapy. (22440994)
2012
18
Comment on: Holstein et al. Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a german longitudinal population-based study. Diabetes Care 2012;35:972-975. (23173147)
2012
19
The importance of hypoglycemia in diabetic patients. (23497433)
2012
20
Hypoglycemia associated with the use of levofloxacin. (19451612)
2009
21
Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes: findings from the Turkish cohort of the PREDICTIVE observational study. (19220776)
2009
22
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
23
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
24
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. (18471680)
2008
25
Severe hypoglycemia in a patient with anorexia nervosa. (18319628)
2008
26
Re: "Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome". (17171485)
2007
27
Prolactin and growth hormone responses to hypoglycemia in patients with systemic sclerosis and psoriatic arthritis. (16855141)
2006
28
Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73. (17070446)
2006
29
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. (15161766)
2004
30
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma. (15223980)
2004
31
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
32
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
33
Paraneoplastic hypoglycemia in localized fibrous tumors of the pleura]. (11195068)
2000
34
5-HT3 serotonergic receptor mediation of hypoglycemia-induced arginine-vasopressin but not oxytocin secretion in normal men. (9633016)
1998
35
Pancreatic alpha-cell function in idiopathic reactive hypoglycemia. (9186298)
1997
36
Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. (9113474)
1997
37
Insulinlike growth factor binding proteins and tumor hypoglycemia. (18406681)
1995
38
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
39
The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. (8425662)
1993
40
Serum estradiol but not gonadotropin levels decrease acutely after insulin-induced hypoglycemia in cycling women. (1400870)
1992
41
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans. (1592870)
1992
42
Prevalence and consequences of nocturnal hypoglycemia among conventionally treated children with diabetes mellitus. (2184211)
1990
43
Changes in the secretion of the hormones of the hypothalamo-hypophyseo-adrenal system in Itsenko-Cushing disease under the influence of insulin-induced hypoglycemia and thyroliberin]. (2164280)
1990
44
The catecholamine response to hypoglycemia in children with isolated growth hormone deficiency syndromes and multiple pituitary hormone defects. (3540823)
1986
45
Isolated ACTH deficiency contributing to frequent hypoglycemia in type I diabetes. (2988889)
1985
46
Hypoglycemia secondary to factitious hyperinsulinism. (7005884)
1981
47
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
48
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. (4358644)
1974
49
Islet cell tumor with hypoglycemia. (4323689)
1971
50
Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides. (4320761)
1970

Variations for Hypoglycemia

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Expression for genes affiliated with Hypoglycemia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for genes affiliated with Hypoglycemia

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Sources:
50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 51PharmGKB
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Pathways related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0KCNJ11, ABCC8
2
Show member pathways
9.8HADH, ACADM
3
Show member pathways
9.7GCK, INS
49.6ABCC8, KCNJ11, GYS2
59.5GYS2, PYGL
6
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.5HADH, ACADL, ACADM
79.5GCK, ACADM, G6PC
8
Show member pathways
9.4INS, KCNJ11, ABCC8
9
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.4FBP1, ACADM, GCK
10
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.3FBP1, G6PC, GCK
11
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
12
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
13
Show member pathways
9.0SLC25A20, ACADM, ACADL, HADH
14
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)38
Fatty Acid Beta Oxidation38
9.0SLC25A20, ACADM, ACADL, HADH
15
Show member pathways
malate-aspartate shuttle38
glycogen biosynthesis II (from UDP-D-Glucose)38
9.0GYS2, FBP1, PYGL
16
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I38
galactose degradation I (Leloir pathway)38
Cori Cycle38
8.9PYGL, G6PC, GYS2, GCK
17
Show member pathways
8.9PYGL, G6PC, GYS2, GCK
18
Show member pathways
8.7ABCC8, G6PC, GCK, SLC22A5
19
Show member pathways
8.3GCK, GYS2, G6PC, FBP1, PYGL
208.2GCK, HADH, ABCC8, KCNJ11, INS, G6PC
21
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
7.8PYGL, INS, FBP1, G6PC, GYS2, GCK
22
Show member pathways
5.9HADH, ABCC8, PYGL, KCNJ11, INS, FBP1

Compounds for genes affiliated with Hypoglycemia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Hypoglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cibenzoline4510.4KCNJ11, ABCC8
2nicorandil45 2911.3ABCC8, KCNJ11
3mgadp4510.3ABCC8, KCNJ11
4cromakalim45 2911.2ABCC8, KCNJ11
5meglitinide4510.1ABCC8, INS
6mitiglinide45 1111.1ABCC8, INS
7Tetradecanoyl-CoA2410.1ACADM, ACADL
8chromium picolinate4510.1GCK, INS
9glipizide45 51 1112.0INS, ABCC8
10preproinsulin4510.0GCK, INS
11FADH2410.0ACADM, ACADL
12chlorpropamide45 51 1112.0ABCC8, INS
13i-app459.9INS, GCK
14repaglinide51 45 1111.9KCNJ11, ABCC8, INS
15gliclazide45 51 1111.9KCNJ11, INS, ABCC8
16glimepiride45 51 1111.8INS, KCNJ11, ABCC8
17pristanic acid45 29 2411.8ACADL, SLC25A20
18c-peptide459.8GCK, KCNJ11, INS
19Heptanoyl-CoA249.8ACADM, ACADL, HADH
20amylose45 2410.7GYS2, PYGL
21fructose-6-phosphate45 1110.7GCK, G6PC, FBP1
22aicar45 24 1111.7G6PC, GCK, INS
23minoxidil45 29 1111.7ABCC8, KCNJ11
24streptozotocin459.7G6PC, GCK, INS
252-deoxyglucose45 1110.6G6PC, GCK, INS
26sulfonylurea459.6INS, ABCC8, KCNJ11, GCK
27tolbutamide45 29 51 1112.6GCK, INS, ABCC8, KCNJ11
28metformin45 51 1111.6ABCC8, KCNJ11, INS, GCK
29incretin459.6GCK, INS
30dhea459.6CRH, INS, G6PC
31glibenclamide45 29 51 6112.6KCNJ11, INS, CRH, ABCC8
32beta-hydroxybutyrate459.5INS, G6PC
33acyl-coa459.4SLC25A20, HADH, ACADL, ACADM
34leucine459.4HADH, G6PC, KCNJ11, ABCC8, GCK
35moxonidine459.4INS, SLC22A5
36glycerol45 24 1111.4G6PC, INS, CRH, GCK
37glutamine459.4KCNJ11, GCK, ACADM, G6PC
38mepyramine45 1110.4CRH, SLC22A5
39katp459.3GCK, INS, KCNJ11, ABCC8, HADH
40diazoxide45 61 29 1112.3GCK, INS, HADH, ABCC8, KCNJ11
41glucose 6-phosphate45 2410.3PYGL, GYS2, GCK, G6PC
42verapamil45 29 51 24 1113.2KCNJ11, CRH, SLC22A5
43lactate459.0INS, GCK, ACADM, G6PC
44glycogen45 249.5G6PC, ABCC8, PYGL, INS, GYS2, GCK
45glutamate458.3G6PC, ABCC8, KCNJ11, INS, CRH, GCK
46lipid458.3G6PC, SLC25A20, GCK, ACADM, INS, ABCC8
47carnitine458.1HADH, ACADM, INS, SLC25A20, ACADL, SLC22A5
48fatty acid458.0ABCC8, HADH, ACADL, ACADM, INS, SLC25A20
49arginine457.3SLC22A5, GCK, CRH, ACADM, INS, KCNJ11
50glucose456.7SLC25A20, GYS2, GCK, ACADM, G6PC, FBP1

GO Terms for genes affiliated with Hypoglycemia

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Sources:
16Gene Ontology
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Cellular components related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057599.5ACADM, ACADL, HADH
2mitochondrionGO:0057398.2SLC25A20, GCK, ACADM, ACADL, KCNJ11, HADH

Biological processes related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epinephrine secretionGO:03281110.2GCK, CRH
2carnitine metabolic process, CoA-linkedGO:01925410.1ACADL, ACADM
3fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.0ACADM, ACADL
4negative regulation of insulin secretionGO:04667610.0KCNJ11, HADH
5negative regulation of gluconeogenesisGO:04572110.0GCK, INS
6positive regulation of glycolytic processGO:0458219.9INS, GCK
7positive regulation of glycogen biosynthetic processGO:0457259.9INS, GCK
8glycogen biosynthetic processGO:0059789.9GCK, GYS2, ACADM
9regulation of gluconeogenesisGO:0061119.9FBP1, ACADM
10fatty acid beta-oxidationGO:0066359.8HADH, ACADL, ACADM
11hexose transportGO:0086459.7GCK, G6PC
12endocrine pancreas developmentGO:0310189.7GCK, INS
13energy reserve metabolic processGO:0061129.7INS, KCNJ11, ABCC8
14response to drugGO:0424939.6CRH, KCNJ11, HADH
15glycogen catabolic processGO:0059809.6PYGL, G6PC
16glucose transportGO:0157589.6G6PC, INS, GCK
17regulation of insulin secretionGO:0507969.5INS, GCK, KCNJ11, ABCC8
18glycogen metabolic processGO:0059779.5G6PC, PYGL
19cellular lipid metabolic processGO:0442559.3SLC25A20, HADH, ACADL, ACADM
20gluconeogenesisGO:0060949.2G6PC, FBP1
21glucose homeostasisGO:0425939.0GCK, PYGL, INS, G6PC
22transmembrane transportGO:0550858.9SLC22A5, GCK, G6PC, ABCC8
23glucose metabolic processGO:0060068.6INS, FBP1, GYS2, PYGL, KCNJ11
24carbohydrate metabolic processGO:0059758.5ABCC8, GCK, GYS2, G6PC, FBP1, PYGL
25small molecule metabolic processGO:0442816.2SLC25A20, HADH, ABCC8, PYGL, INS, FBP1

Molecular functions related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acyl-CoA dehydrogenase activityGO:0039959.7ACADM, ACADL
2glucose bindingGO:0055369.6PYGL, GCK
3AMP bindingGO:0162089.0FBP1, PYGL
4ATP bindingGO:0055248.3KCNJ11, ABCC8, GCK, SLC22A5, PYGL

Products for genes affiliated with Hypoglycemia

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Hypoglycemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet