MCID: HYP056
MIFTS: 62

Hypoglycemia malady

Summaries for Hypoglycemia

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MedlinePlus:34 Hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia and insulinoma. An important gene associated with Hypoglycemia is ABCC8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8), and among its related pathways are Inwardly rectifying K+ channels and Beta oxidation of octanoyl-CoA to hexanoyl-CoA. The drugs diazoxide and glucagon and the compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:65 Hypoglycemia (also spelled hypoglycaemia or hypoglyc more...

Aliases & Classifications for Hypoglycemia

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Hypoglycemia, Aliases & Descriptions:

Name: Hypoglycemia 10 12 45 34 62
 
Hypoglycaemia 10 62


External Ids:

Disease Ontology10 DOID:9993
NCIt40 C3126
MeSH35 D007003
ICD9CM29 251.2

Related Diseases for Hypoglycemia

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Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 419)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia31.5INS, ABCC8
2insulinoma30.9KCNJ11, ABCC8, INS, G6PC, GCK
3hyperinsulinemic hypoglycemia, familial, 230.8KCNJ11, ABCC8, HADH, GCK
4hyperinsulinism30.7ABCC8, GCK, G6PC, INS, KCNJ11
5lactic acidosis30.6INS, G6PC
6hyperglycemia30.6INS, ABCC8, G6PC, GCK, PYGL, FBP1
7growth hormone deficiency30.5CRH, INS
8glycogen storage disease30.4PYGL, G6PC
9maturity-onset diabetes of the young30.3KCNJ11, GCK, INS
10obesity30.3ABCC8, KCNJ11, INS, CRH, GCK
11hypopituitarism30.2INS, CRH
12galactosemia30.2ACADM, SLC25A20
133-hydroxyacyl-coa dehydrogenase deficiency30.1HADH
14neonatal diabetes mellitus30.1GCK, KCNJ11, INS, ABCC8
15cushing's syndrome29.9INS, CRH
16glycogen storage disease vi29.9PYGL, G6PC
17amenorrhea29.7CRH, INS
18diabetes mellitus, insulin-dependent29.7GCK, INS
19glucose intolerance29.7GCK, INS
20hyperuricemia29.7G6PC, INS, GCK
21cystic fibrosis29.7KCNJ11, ABCC8, INS, ACADM
22islet cell tumor10.7
23fasting hypoglycemia10.7
24pancreatitis10.6
25hemangiopericytoma10.4
26hyperinsulinemic hypoglycemia, familial, 710.4
27hypoglycemia of infancy, leucine-sensitive10.4
28hepatitis10.4
29neuronitis10.4
30insulin autoimmune syndrome10.3
31cerebritis10.3
32autonomic neuropathy10.3
33neuropathy10.3
34hyperinsulinemic hypoglycemia, familial, 310.2
35hyperinsulinemic hypoglycemia, familial, 110.2
36insulin-like growth factor i10.2
37acth deficiency10.2
38gastrointestinal stromal tumor10.2
39hepatocellular carcinoma10.2
40beckwith-wiedemann syndrome10.2
41diabetic autonomic neuropathy10.2
42dumping syndrome10.2
43thyroiditis10.2
44endotheliitis10.2
45phaeochromocytoma10.2
46hypoinsulinemic hypoglycemia with hemihypertrophy10.2
47hyperinsulinism-hyperammonemia syndrome10.2
48ischemia10.2
49hypoxia10.2
50blindness10.2

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to hypoglycemia

Symptoms for Hypoglycemia

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Drugs & Therapeutics for Hypoglycemia

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Drug clinical trials:

Search ClinicalTrials for Hypoglycemia

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hypoglycemia

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Anatomical Context for Hypoglycemia

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MalaCards organs/tissues related to Hypoglycemia:

33
Liver, Testes, Kidney, Brain, Pituitary, Pancreas, Thyroid, Endothelial, Pancreatic islet, Cortex, Breast, Heart, Bone, Skeletal muscle, Lung, Hypothalamus, Spleen, Ovary, B cells, Bone marrow, Spinal cord, Colon, Uterus, Monocytes, T cells, Cingulate cortex, Parietal lobe, Adrenal cortex

Animal Models for Hypoglycemia or affiliated genes

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MGI Mouse Phenotypes related to Hypoglycemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5HADH, ABCC8, KCNJ11, INS, CRH, GCK
2MP:00053677.8HADH, INS, G6PC, ACADL, GCK, SLC22A5
3MP:00053787.6KCNJ11, INS, G6PC, CRH, GCK, SLC22A5
4MP:00053857.5KCNJ11, INS, GYS2, ACADL, ACADM, SLC22A5
5MP:00053707.5INS, G6PC, GYS2, ACADL, ACADM, GCK
6MP:00053766.4SLC22A5, HADH, ABCC8, KCNJ11, INS, G6PC

Publications for Hypoglycemia

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Articles related to Hypoglycemia:

(show top 50)    (show all 1413)
idTitleAuthorsYear
1
The BARMER-Study: Impact of Standardized Warming of the Injection-site to Enhance Insulin Absorption and Reduce Prandial Insulin Requirements and Hypoglycemia in Obese Patients with Diabetes mellitus. (24392996)
2014
2
Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn. (23751383)
2013
3
Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine. (23874102)
2013
4
Medical resource use, disturbance of daily life and burden of hypoglycemia in insulin-treated patients with diabetes: results from a European online survey. (23402452)
2013
5
Diffusion-weighted imaging changes caused by acute hypoglycemia and prolonged febrile convulsion in childhood. (23471020)
2013
6
Impact of hypoglycemia in hospitalized patients. (23065370)
2013
7
The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. (24212718)
2013
8
Engineering a control system for hypoglycemia prevention, detection, and intervention in critical care*. (24096688)
2013
9
Anti-insulin receptor antibodies related to hypoglycemia in a previously diabetic patient. (23704685)
2013
10
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
11
Insulin pumps with a sensor and threshold-suspend reduced nocturnal hypoglycemia in type 1 diabetes. (24042390)
2013
12
New insights and new conundrums in neonatal hypoglycemia: enigmas wrapped in mystery. (23613554)
2013
13
A 10-s sprint performed after moderate-intensity exercise neither increases nor decreases the glucose requirement to prevent late-onset hypoglycemia in individuals with type 1 diabetes. (24130362)
2013
14
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
15
Prevention of hypoglycemia-induced neuronal death by minocycline. (22998689)
2012
16
Risk of postoperative hypoglycemia in cardiovascular surgical patients receiving computer-based versus paper-based insulin therapy. (22440994)
2012
17
Comment on: Holstein et al. Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a german longitudinal population-based study. Diabetes Care 2012;35:972-975. (23173147)
2012
18
The importance of hypoglycemia in diabetic patients. (23497433)
2012
19
Hypoglycemia associated with the use of levofloxacin. (19451612)
2009
20
Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes: findings from the Turkish cohort of the PREDICTIVE observational study. (19220776)
2009
21
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
22
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
23
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. (18471680)
2008
24
Severe hypoglycemia in a patient with anorexia nervosa. (18319628)
2008
25
Re: "Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome". (17171485)
2007
26
Prolactin and growth hormone responses to hypoglycemia in patients with systemic sclerosis and psoriatic arthritis. (16855141)
2006
27
Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73. (17070446)
2006
28
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. (15161766)
2004
29
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma. (15223980)
2004
30
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
31
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
32
Hypoglycemia During Therapy of Diabetes (25905325)
2000
33
Paraneoplastic hypoglycemia in localized fibrous tumors of the pleura]. (11195068)
2000
34
5-HT3 serotonergic receptor mediation of hypoglycemia-induced arginine-vasopressin but not oxytocin secretion in normal men. (9633016)
1998
35
Pancreatic alpha-cell function in idiopathic reactive hypoglycemia. (9186298)
1997
36
Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. (9113474)
1997
37
Insulinlike growth factor binding proteins and tumor hypoglycemia. (18406681)
1995
38
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
39
The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. (8425662)
1993
40
Serum estradiol but not gonadotropin levels decrease acutely after insulin-induced hypoglycemia in cycling women. (1400870)
1992
41
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans. (1592870)
1992
42
Prevalence and consequences of nocturnal hypoglycemia among conventionally treated children with diabetes mellitus. (2184211)
1990
43
Changes in the secretion of the hormones of the hypothalamo-hypophyseo-adrenal system in Itsenko-Cushing disease under the influence of insulin-induced hypoglycemia and thyroliberin]. (2164280)
1990
44
The catecholamine response to hypoglycemia in children with isolated growth hormone deficiency syndromes and multiple pituitary hormone defects. (3540823)
1986
45
Isolated ACTH deficiency contributing to frequent hypoglycemia in type I diabetes. (2988889)
1985
46
Hypoglycemia secondary to factitious hyperinsulinism. (7005884)
1981
47
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
48
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. (4358644)
1974
49
Islet cell tumor with hypoglycemia. (4323689)
1971
50
Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides. (4320761)
1970

Variations for Hypoglycemia

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Expression for genes affiliated with Hypoglycemia

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Search GEO for disease gene expression data for Hypoglycemia.

Pathways for genes affiliated with Hypoglycemia

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Pathways related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0KCNJ11, ABCC8
2
Show member pathways
9.8HADH, ACADM
3
Show member pathways
9.7GCK, INS
49.6ABCC8, KCNJ11, GYS2
59.5GYS2, PYGL
6
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.5HADH, ACADL, ACADM
79.5GCK, ACADM, G6PC
8
Show member pathways
9.4INS, KCNJ11, ABCC8
9
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.4FBP1, ACADM, GCK
10
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.3FBP1, G6PC, GCK
11
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
12
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
13
Show member pathways
9.0SLC25A20, ACADM, ACADL, HADH
14
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)38
Fatty Acid Beta Oxidation38
9.0SLC25A20, ACADM, ACADL, HADH
15
Show member pathways
malate-aspartate shuttle38
glycogen biosynthesis II (from UDP-D-Glucose)38
9.0GYS2, FBP1, PYGL
16
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I38
galactose degradation I (Leloir pathway)38
Cori Cycle38
8.9PYGL, G6PC, GYS2, GCK
17
Show member pathways
8.9PYGL, G6PC, GYS2, GCK
18
Show member pathways
8.7ABCC8, G6PC, GCK, SLC22A5
19
Show member pathways
8.3GCK, GYS2, G6PC, FBP1, PYGL
208.2GCK, HADH, ABCC8, KCNJ11, INS, G6PC
21
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
7.8PYGL, INS, FBP1, G6PC, GYS2, GCK
22
Show member pathways
5.9HADH, ABCC8, PYGL, KCNJ11, INS, FBP1

Compounds for genes affiliated with Hypoglycemia

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Compounds related to Hypoglycemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cibenzoline4510.4KCNJ11, ABCC8
2nicorandil45 3011.3KCNJ11, ABCC8
3mgadp4510.3KCNJ11, ABCC8
4cromakalim45 3011.2KCNJ11, ABCC8
5meglitinide4510.1ABCC8, INS
6Tetradecanoyl-CoA2610.1ACADL, ACADM
7mitiglinide45 1311.1INS, ABCC8
8chromium picolinate4510.1INS, GCK
9glipizide45 51 1312.0ABCC8, INS
10FADH2610.0ACADL, ACADM
11preproinsulin4510.0INS, GCK
12chlorpropamide45 51 1312.0INS, ABCC8
13minoxidil45 30 1312.0ABCC8, KCNJ11
14i-app459.9INS, GCK
15repaglinide51 45 1311.9INS, KCNJ11, ABCC8
16gliclazide45 51 1311.9ABCC8, KCNJ11, INS
17glimepiride45 51 1311.8INS, KCNJ11, ABCC8
18pristanic acid45 30 2611.8SLC25A20, ACADL
19c-peptide459.8GCK, INS, KCNJ11
20Heptanoyl-CoA269.8HADH, ACADL, ACADM
21amylose45 2610.8PYGL, GYS2
22fructose-6-phosphate45 1310.7GCK, G6PC, FBP1
23aicar45 26 1311.7GCK, G6PC, INS
24streptozotocin459.7INS, G6PC, GCK
252-deoxyglucose45 1310.6INS, G6PC, GCK
26sulfonylurea459.6ABCC8, KCNJ11, INS, GCK
27tolbutamide45 30 51 1312.6ABCC8, KCNJ11, INS, GCK
28metformin45 51 1311.6ABCC8, KCNJ11, INS, GCK
29incretin459.6INS, GCK
30dhea459.6INS, G6PC, CRH
31glibenclamide45 30 51 6112.6ABCC8, KCNJ11, INS, CRH
32acyl-coa459.4HADH, ACADL, ACADM, SLC25A20
33leucine459.4HADH, ABCC8, KCNJ11, G6PC, GCK
34glycerol45 26 1311.4INS, G6PC, CRH, GCK
35glutamine459.4KCNJ11, G6PC, ACADM, GCK
36mepyramine45 1310.4SLC22A5, CRH
37katp459.3HADH, ABCC8, KCNJ11, INS, GCK
38diazoxide45 61 30 1312.3HADH, ABCC8, KCNJ11, INS, GCK
39moxonidine459.3INS, SLC22A5
40glucose 6-phosphate45 2610.3PYGL, G6PC, GYS2, GCK
41beta-hydroxybutyrate459.2INS, G6PC
42verapamil45 30 51 26 1313.2KCNJ11, CRH, SLC22A5
43lactate459.0GCK, ACADM, G6PC, INS
44glycogen45 269.5ABCC8, PYGL, INS, G6PC, GYS2, GCK
45glutamate458.3HADH, ABCC8, KCNJ11, INS, G6PC, ACADM
46lipid458.3ABCC8, INS, G6PC, ACADL, ACADM, GCK
47carnitine458.1HADH, INS, ACADL, ACADM, SLC22A5, SLC25A20
48fatty acid458.0HADH, ABCC8, INS, G6PC, ACADL, ACADM
49arginine457.3ABCC8, KCNJ11, INS, G6PC, ACADM, CRH
50glucose456.7SLC25A20, HADH, ABCC8, PYGL, KCNJ11, INS

GO Terms for genes affiliated with Hypoglycemia

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Cellular components related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057599.5ACADM, ACADL, HADH
2mitochondrionGO:00057398.2SLC25A20, GCK, ACADM, ACADL, KCNJ11, HADH

Biological processes related to Hypoglycemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epinephrine secretionGO:003281110.2CRH, GCK
2carnitine metabolic process, CoA-linkedGO:001925410.1ACADM, ACADL
3fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:003353910.0ACADL, ACADM
4negative regulation of insulin secretionGO:004667610.0HADH, KCNJ11
5negative regulation of gluconeogenesisGO:004572110.0INS, GCK
6positive regulation of glycolytic processGO:00458219.9GCK, INS
7positive regulation of glycogen biosynthetic processGO:00457259.9INS, GCK
8glycogen biosynthetic processGO:00059789.9GYS2, ACADM, GCK
9regulation of gluconeogenesisGO:00061119.9FBP1, ACADM
10fatty acid beta-oxidationGO:00066359.8HADH, ACADL, ACADM
11hexose transportGO:00086459.7G6PC, GCK
12endocrine pancreas developmentGO:00310189.7GCK, INS
13energy reserve metabolic processGO:00061129.7INS, KCNJ11, ABCC8
14response to drugGO:00424939.6CRH, KCNJ11, HADH
15glycogen catabolic processGO:00059809.6G6PC, PYGL
16glucose transportGO:00157589.6GCK, G6PC, INS
17regulation of insulin secretionGO:00507969.5ABCC8, KCNJ11, INS, GCK
18glycogen metabolic processGO:00059779.5PYGL, G6PC
19cellular lipid metabolic processGO:00442559.3SLC25A20, ACADM, ACADL, HADH
20gluconeogenesisGO:00060949.2G6PC, FBP1
21glucose homeostasisGO:00425939.0PYGL, INS, G6PC, GCK
22transmembrane transportGO:00550858.9SLC22A5, GCK, G6PC, ABCC8
23glucose metabolic processGO:00060068.6PYGL, KCNJ11, INS, FBP1, GYS2
24carbohydrate metabolic processGO:00059758.5ABCC8, PYGL, FBP1, G6PC, GYS2, GCK
25small molecule metabolic processGO:00442816.2SLC25A20, HADH, ABCC8, PYGL, KCNJ11, INS

Molecular functions related to Hypoglycemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose bindingGO:00055369.6GCK, PYGL
2acyl-CoA dehydrogenase activityGO:00039959.5ACADL, ACADM
3AMP bindingGO:00162089.2PYGL, FBP1
4ATP bindingGO:00055248.3SLC22A5, GCK, KCNJ11, PYGL, ABCC8

Products for genes affiliated with Hypoglycemia

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Sources for Hypoglycemia

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4CDC
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24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
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44NINDS
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