MCID: HYP056
MIFTS: 53

Hypoglycemia malady

Summaries for Hypoglycemia

About this section


MedlinePlus:32 Hypoglycemia means low blood glucose, or blood sugar. your body needs glucose to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles, and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak in people with diabetes, hypoglycemia is often a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. laboratory tests can help find the cause. the kind of treatment depends on why you have low blood sugar. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia and hyperinsulinemic hypoglycemia, familial, 2. An important gene associated with Hypoglycemia is ABCC8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8), and among its related pathways are Inwardly rectifying K+ channels and Beta oxidation of octanoyl-CoA to hexanoyl-CoA. The drugs diazoxide and glucagon and the compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:63 Hypoglycemia (also spelled hypoglycaemia or hypoglyc more...

Aliases & Classifications for Hypoglycemia

About this section

Hypoglycemia, Aliases & Descriptions:

Name: Hypoglycemia 9 11 43 32 60
 
Hypoglycaemia 9


External Ids:

Disease Ontology9 DOID:9993
NCIt38 C3126
MeSH33 D007003
ICD9CM27 251.2

Related Diseases for Hypoglycemia

About this section

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 420)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia31.4INS, GCK, KCNJ11, ABCC8, HADH
2hyperinsulinemic hypoglycemia, familial, 231.2INS, ABCC8
3lactic acidosis30.8INS, G6PC
43-hydroxyacyl-coa dehydrogenase deficiency30.8HADH
5growth hormone deficiency30.8CRH, INS
6insulinoma30.7KCNJ11, ABCC8, INS, G6PC, GCK
7hyperinsulinism30.6ABCC8, GCK, G6PC, INS, KCNJ11
8maturity-onset diabetes of the young30.6KCNJ11, GCK, INS
9hypopituitarism30.5INS, CRH
10glycogen storage disease30.5PYGL, G6PC
11galactosemia30.3ACADM, SLC25A20
12obesity30.2ABCC8, KCNJ11, INS, CRH, GCK
13cushing's syndrome30.2INS, CRH
14neonatal diabetes mellitus30.2GCK, KCNJ11, INS, ABCC8
15glycogen storage disease vi30.1PYGL, G6PC
16amenorrhea30.0CRH, INS
17diabetes mellitus, insulin-dependent29.9GCK, INS
18glucose intolerance29.9GCK, INS
19hyperglycemia29.8INS, ABCC8, G6PC, GCK, PYGL, FBP1
20hyperuricemia29.8G6PC, INS, GCK
21cystic fibrosis29.7KCNJ11, ABCC8, INS, ACADM
22islet cell tumor10.7
23fasting hypoglycemia10.7
24pancreatitis10.6
25endogenous depression10.5CRH
26hemangiopericytoma10.4
27hyperinsulinemic hypoglycemia, familial, 710.4
28hypoglycemia of infancy, leucine-sensitive10.4
29hepatitis10.4
30neuronitis10.4
31insulin autoimmune syndrome10.3
32hyperinsulinemic hypoglycemia, familial, 310.3
33cerebritis10.3
34medium-chain acyl-coenzyme a dehydrogenase deficiency10.3ACADM, ACADL
35hyperinsulinemic hypoglycemia, familial, 110.3
36autonomic neuropathy10.3
37neuropathy10.3
38insulin-like growth factor i10.2
39acth deficiency10.2
40pituitary gland disease10.2CRH, INS
41congenital adrenal hyperplasia10.2ACADM, CRH
42spinocerebellar ataxia10.2ACADM, SLC25A20
43gastrointestinal stromal tumor10.2
44hepatocellular carcinoma10.2
45beckwith-wiedemann syndrome10.2
46hypoinsulinemic hypoglycemia with hemihypertrophy10.2
47diabetic autonomic neuropathy10.2
48dumping syndrome10.2
49thyroiditis10.2
50endotheliitis10.2

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to hypoglycemia

Symptoms for Hypoglycemia

About this section

Drugs & Therapeutics for Hypoglycemia

About this section

Drug clinical trials:

Search ClinicalTrials for Hypoglycemia

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hypoglycemia

About this section

Anatomical Context for Hypoglycemia

About this section

MalaCards organs/tissues related to Hypoglycemia:

31
Liver, Testes, Kidney, Brain, Pituitary, Pancreas, Thyroid, Endothelial, Pancreatic islet, Cortex, Breast, Heart, Bone, Skeletal muscle, Lung, Hypothalamus, Spleen, Ovary, B cells, Bone marrow, Spinal cord, Colon, Uterus, Monocytes, T cells, Cingulate cortex, Parietal lobe, Adrenal cortex

Animal Models for Hypoglycemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Hypoglycemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5HADH, ABCC8, KCNJ11, INS, CRH, GCK
2MP:00053677.8HADH, INS, G6PC, ACADL, GCK, SLC22A5
3MP:00053787.6KCNJ11, INS, G6PC, CRH, GCK, SLC22A5
4MP:00053857.5KCNJ11, INS, GYS2, ACADL, ACADM, SLC22A5
5MP:00053707.5INS, G6PC, GYS2, ACADL, ACADM, GCK
6MP:00053766.4SLC22A5, HADH, ABCC8, KCNJ11, INS, G6PC

Publications for Hypoglycemia

About this section

Articles related to Hypoglycemia:

(show top 50)    (show all 1413)
idTitleAuthorsYear
1
The BARMER-Study: Impact of Standardized Warming of the Injection-site to Enhance Insulin Absorption and Reduce Prandial Insulin Requirements and Hypoglycemia in Obese Patients with Diabetes mellitus. (24392996)
2014
2
Treatment of hyperinsulinemic hypoglycemia because of diffuse nesidioblastosis with nifedipine after surgical therapies in a newborn. (23751383)
2013
3
Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine. (23874102)
2013
4
Medical resource use, disturbance of daily life and burden of hypoglycemia in insulin-treated patients with diabetes: results from a European online survey. (23402452)
2013
5
Diffusion-weighted imaging changes caused by acute hypoglycemia and prolonged febrile convulsion in childhood. (23471020)
2013
6
Impact of hypoglycemia in hospitalized patients. (23065370)
2013
7
The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. (24212718)
2013
8
Engineering a control system for hypoglycemia prevention, detection, and intervention in critical care*. (24096688)
2013
9
Anti-insulin receptor antibodies related to hypoglycemia in a previously diabetic patient. (23704685)
2013
10
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins. (22934852)
2013
11
Insulin pumps with a sensor and threshold-suspend reduced nocturnal hypoglycemia in type 1 diabetes. (24042390)
2013
12
New insights and new conundrums in neonatal hypoglycemia: enigmas wrapped in mystery. (23613554)
2013
13
A 10-s sprint performed after moderate-intensity exercise neither increases nor decreases the glucose requirement to prevent late-onset hypoglycemia in individuals with type 1 diabetes. (24130362)
2013
14
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. (22166985)
2012
15
Prevention of hypoglycemia-induced neuronal death by minocycline. (22998689)
2012
16
Risk of postoperative hypoglycemia in cardiovascular surgical patients receiving computer-based versus paper-based insulin therapy. (22440994)
2012
17
Comment on: Holstein et al. Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a german longitudinal population-based study. Diabetes Care 2012;35:972-975. (23173147)
2012
18
The importance of hypoglycemia in diabetic patients. (23497433)
2012
19
Hypoglycemia associated with the use of levofloxacin. (19451612)
2009
20
Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes: findings from the Turkish cohort of the PREDICTIVE observational study. (19220776)
2009
21
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
22
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
23
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. (18471680)
2008
24
Severe hypoglycemia in a patient with anorexia nervosa. (18319628)
2008
25
Re: "Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome". (17171485)
2007
26
Prolactin and growth hormone responses to hypoglycemia in patients with systemic sclerosis and psoriatic arthritis. (16855141)
2006
27
Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73. (17070446)
2006
28
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. (15161766)
2004
29
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma. (15223980)
2004
30
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
31
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
32
Hypoglycemia During Therapy of Diabetes (25905325)
2000
33
Paraneoplastic hypoglycemia in localized fibrous tumors of the pleura]. (11195068)
2000
34
5-HT3 serotonergic receptor mediation of hypoglycemia-induced arginine-vasopressin but not oxytocin secretion in normal men. (9633016)
1998
35
Pancreatic alpha-cell function in idiopathic reactive hypoglycemia. (9186298)
1997
36
Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. (9113474)
1997
37
Insulinlike growth factor binding proteins and tumor hypoglycemia. (18406681)
1995
38
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
39
The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. (8425662)
1993
40
Serum estradiol but not gonadotropin levels decrease acutely after insulin-induced hypoglycemia in cycling women. (1400870)
1992
41
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans. (1592870)
1992
42
Prevalence and consequences of nocturnal hypoglycemia among conventionally treated children with diabetes mellitus. (2184211)
1990
43
Changes in the secretion of the hormones of the hypothalamo-hypophyseo-adrenal system in Itsenko-Cushing disease under the influence of insulin-induced hypoglycemia and thyroliberin]. (2164280)
1990
44
The catecholamine response to hypoglycemia in children with isolated growth hormone deficiency syndromes and multiple pituitary hormone defects. (3540823)
1986
45
Isolated ACTH deficiency contributing to frequent hypoglycemia in type I diabetes. (2988889)
1985
46
Hypoglycemia secondary to factitious hyperinsulinism. (7005884)
1981
47
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
48
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. (4358644)
1974
49
Islet cell tumor with hypoglycemia. (4323689)
1971
50
Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides. (4320761)
1970

Variations for Hypoglycemia

About this section

Expression for genes affiliated with Hypoglycemia

About this section
Search GEO for disease gene expression data for Hypoglycemia.

Pathways for genes affiliated with Hypoglycemia

About this section

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0KCNJ11, ABCC8
2
Show member pathways
9.8HADH, ACADM
3
Show member pathways
9.7GCK, INS
49.6ABCC8, KCNJ11, GYS2
59.5GYS2, PYGL
6
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
9.5HADH, ACADL, ACADM
79.5GCK, ACADM, G6PC
8
Show member pathways
9.4INS, KCNJ11, ABCC8
9
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.4FBP1, ACADM, GCK
10
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.3FBP1, G6PC, GCK
11
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
12
Show member pathways
9.2ABCC8, KCNJ11, INS, GCK
13
Show member pathways
9.0SLC25A20, ACADM, ACADL, HADH
14
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)36
Fatty Acid Beta Oxidation36
9.0SLC25A20, ACADM, ACADL, HADH
15
Show member pathways
malate-aspartate shuttle36
glycogen biosynthesis II (from UDP-D-Glucose)36
9.0GYS2, FBP1, PYGL
16
Show member pathways
UDP-N-acetyl-D-galactosamine biosynthesis I36
galactose degradation I (Leloir pathway)36
Cori Cycle36
8.9PYGL, G6PC, GYS2, GCK
17
Show member pathways
8.9PYGL, G6PC, GYS2, GCK
18
Show member pathways
8.7ABCC8, G6PC, GCK, SLC22A5
19
Show member pathways
8.3GCK, GYS2, G6PC, FBP1, PYGL
208.2GCK, HADH, ABCC8, KCNJ11, INS, G6PC
21
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
7.8PYGL, INS, FBP1, G6PC, GYS2, GCK
22
Show member pathways
5.9HADH, ABCC8, PYGL, KCNJ11, INS, FBP1

Compounds for genes affiliated with Hypoglycemia

About this section

Compounds related to Hypoglycemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cibenzoline4310.4KCNJ11, ABCC8
2nicorandil43 2811.3ABCC8, KCNJ11
3mgadp4310.3ABCC8, KCNJ11
4cromakalim43 2811.2ABCC8, KCNJ11
5meglitinide4310.1ABCC8, INS
6mitiglinide43 1211.1ABCC8, INS
7Tetradecanoyl-CoA2410.1ACADM, ACADL
8chromium picolinate4310.1GCK, INS
9glipizide43 49 1212.0INS, ABCC8
10preproinsulin4310.0GCK, INS
11FADH2410.0ACADM, ACADL
12chlorpropamide43 49 1212.0ABCC8, INS
13i-app439.9INS, GCK
14repaglinide49 43 1211.9KCNJ11, ABCC8, INS
15gliclazide43 49 1211.9KCNJ11, INS, ABCC8
16glimepiride43 49 1211.8INS, KCNJ11, ABCC8
17pristanic acid43 28 2411.8ACADL, SLC25A20
18c-peptide439.8GCK, KCNJ11, INS
19Heptanoyl-CoA249.8ACADM, ACADL, HADH
20amylose43 2410.7GYS2, PYGL
21fructose-6-phosphate43 1210.7GCK, G6PC, FBP1
22aicar43 24 1211.7G6PC, GCK, INS
23minoxidil43 28 1211.7ABCC8, KCNJ11
24streptozotocin439.7G6PC, GCK, INS
252-deoxyglucose43 1210.6G6PC, GCK, INS
26sulfonylurea439.6INS, ABCC8, KCNJ11, GCK
27tolbutamide43 28 49 1212.6GCK, INS, ABCC8, KCNJ11
28metformin43 49 1211.6ABCC8, KCNJ11, INS, GCK
29incretin439.6GCK, INS
30dhea439.6CRH, INS, G6PC
31glibenclamide43 28 49 5912.6KCNJ11, INS, CRH, ABCC8
32beta-hydroxybutyrate439.5INS, G6PC
33acyl-coa439.4SLC25A20, HADH, ACADL, ACADM
34leucine439.4HADH, G6PC, KCNJ11, ABCC8, GCK
35moxonidine439.4INS, SLC22A5
36glycerol43 24 1211.4G6PC, INS, CRH, GCK
37glutamine439.4KCNJ11, GCK, ACADM, G6PC
38mepyramine43 1210.4CRH, SLC22A5
39katp439.3GCK, INS, KCNJ11, ABCC8, HADH
40diazoxide43 59 28 1212.3GCK, INS, HADH, ABCC8, KCNJ11
41glucose 6-phosphate43 2410.3PYGL, GYS2, GCK, G6PC
42verapamil43 28 49 24 1213.2KCNJ11, CRH, SLC22A5
43lactate439.0INS, GCK, ACADM, G6PC
44glycogen43 249.5G6PC, ABCC8, PYGL, INS, GYS2, GCK
45glutamate438.3G6PC, ABCC8, KCNJ11, INS, CRH, GCK
46lipid438.3G6PC, SLC25A20, GCK, ACADM, INS, ABCC8
47carnitine438.1HADH, ACADM, INS, SLC25A20, ACADL, SLC22A5
48fatty acid438.0ABCC8, HADH, ACADL, ACADM, INS, SLC25A20
49arginine437.3SLC22A5, GCK, CRH, ACADM, INS, KCNJ11
50glucose436.7SLC25A20, GYS2, GCK, ACADM, G6PC, FBP1

GO Terms for genes affiliated with Hypoglycemia

About this section

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057599.5ACADM, ACADL, HADH
2mitochondrionGO:00057398.2SLC25A20, GCK, ACADM, ACADL, KCNJ11, HADH

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epinephrine secretionGO:003281110.2CRH, GCK
2carnitine metabolic process, CoA-linkedGO:001925410.1ACADM, ACADL
3fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:003353910.0ACADL, ACADM
4negative regulation of insulin secretionGO:004667610.0HADH, KCNJ11
5negative regulation of gluconeogenesisGO:004572110.0INS, GCK
6positive regulation of glycolytic processGO:00458219.9GCK, INS
7positive regulation of glycogen biosynthetic processGO:00457259.9INS, GCK
8glycogen biosynthetic processGO:00059789.9GYS2, ACADM, GCK
9regulation of gluconeogenesisGO:00061119.9FBP1, ACADM
10fatty acid beta-oxidationGO:00066359.8HADH, ACADL, ACADM
11hexose transportGO:00086459.7G6PC, GCK
12endocrine pancreas developmentGO:00310189.7GCK, INS
13energy reserve metabolic processGO:00061129.7INS, KCNJ11, ABCC8
14response to drugGO:00424939.6CRH, KCNJ11, HADH
15glycogen catabolic processGO:00059809.6G6PC, PYGL
16glucose transportGO:00157589.6GCK, G6PC, INS
17regulation of insulin secretionGO:00507969.5ABCC8, KCNJ11, INS, GCK
18glycogen metabolic processGO:00059779.5PYGL, G6PC
19cellular lipid metabolic processGO:00442559.3SLC25A20, ACADM, ACADL, HADH
20gluconeogenesisGO:00060949.2G6PC, FBP1
21glucose homeostasisGO:00425939.0PYGL, INS, G6PC, GCK
22transmembrane transportGO:00550858.9SLC22A5, GCK, G6PC, ABCC8
23glucose metabolic processGO:00060068.6PYGL, KCNJ11, INS, FBP1, GYS2
24carbohydrate metabolic processGO:00059758.5ABCC8, PYGL, FBP1, G6PC, GYS2, GCK
25small molecule metabolic processGO:00442816.2SLC25A20, HADH, ABCC8, PYGL, KCNJ11, INS

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glucose bindingGO:00055369.6GCK, PYGL
2acyl-CoA dehydrogenase activityGO:00039959.5ACADL, ACADM
3AMP bindingGO:00162089.2PYGL, FBP1
4ATP bindingGO:00055248.3SLC22A5, GCK, KCNJ11, PYGL, ABCC8

Products for genes affiliated with Hypoglycemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hypoglycemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet