Hypoglycemia malady

MedlinePlus: Did you know you have sugar in your blood? your body needs glucose, a form of sugar, to have enough energy. after you eat, your blood absorbs glucose. if you eat more sugar than your body needs, your muscles and liver store the extra. when your blood sugar begins to fall, a hormone tells your liver to release glucose. in most people, this raises blood sugar. if it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. signs include hunger shakiness dizziness confusion difficulty speaking feeling anxious or weak hypoglycemia is usually a side effect of diabetes medicines. eating or drinking something with carbohydrates can help. if it happens often, your health care provider may need to change your treatment plan. you can also have low blood sugar without having diabetes. in that case, your health care provider will try to find the cause using laboratory tests to measure blood glucose, insulin and other chemicals that play a part in the body's use of energy.²³

MalaCards: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia and persistent hyperinsulinemic hypoglycemia of infancy. An important gene associated with Hypoglycemia is ABCC8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8), and among its related pathways are Maturity onset diabetes of the young and Glucose / Energy Metabolism. The drugs glucose and glucagon and the compounds adenylate and glucose have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and skeletal muscle, and related mouse phenotypes are liver/biliary system and adipose tissue.

Wikipedia: Hypoglycemia (also spelled hypoglycaemia or hypoglycæmia, not to be confused with hyperglycemia) is an...⁴⁴ more...

Aliases & Descriptions:

hypoglycemia 6 17 8 32 23 43 hypoglycaemia 6

Diseases related to hypoglycemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1007)

id	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia	36.5	SCT, CHGA, INS, IGF2, SST, ABCC8
2	persistent hyperinsulinemic hypoglycemia of infancy	35.9	GCK, KCNJ11, GLUD1, ABCC8, HADH
3	hypoglycemia of infancy	35.5	GCK, SEL1L, VIM, KCNJ11, KCNJ5, INS
4	leucine-sensitive hypoglycemia of infancy	32.3	GCK, KCNJ11, GLUD1, ABCC8
5	maturity-onset diabetes of the young	30.9	PCK2, PCK1, GCK, GCG, KCNJ11, FOXA2
6	glycogen storage disease type 0	30.7	GYG2, GYS1, GYS2, AGL
7	hemangiopericytoma	30.3	VIM, VEGFA, FGF2, IGF1R, IGF2, IGFBP3
8	beckwith-wiedemann syndrome	30.1	KCNJ11, INS, IGF1R, IGF2R, IGF2, SST
9	carnitine-acylcarnitine translocase deficiency	30.1	SLC25A20, CPT1A, CPT2
10	hyperinsulinism-hyperammonemia syndrome	29.9	KCNJ5, INS, GLUD1
11	hyperinsulinism	29.8	GCK, GCG, LPL, KCNJ11, KCNJ12, KCNJ5
12	alcoholism	29.8	SCT, GRIN1, CCK, GLUD1, GHRH, GHRL
13	lactic acidosis	29.7	PC, BTD, GHRH, SOD2, HADHA
14	insulinoma	29.7	PIK3CG, PC, PCSK1, GCK, GCG, KCNJ11
15	insulin autoimmune syndrome	29.6	INS, INSR, F5
16	glycogen storage disease	29.4	GCG, BTD, LPL, GYG2, GYS1, GYS2
17	autonomic neuropathy	29.3	GCG, INS, CCK, IGF1, ALB, AKR1B1
18	type 1 diabetes mellitus	29.2	PIK3CG, GCK, GCG, SEL1L, SCT, LEP
19	meninges hemangiopericytoma	29.1	VIM, IGF2, IGFBP3, DES
20	neonatal diabetes mellitus	29.1	GCK, KCNJ11, KCNJ5, INS, IGF1, PDX1
21	neuroendocrine tumor	29.1	GCG, SCT, CHGA, MEN1, ENO2, CCK
22	glycogen storage disease type 1b	28.8	G6PC, CSF3, SLC37A4
23	hemihypertrophy	28.7	INSR, IGF2, ABCC8, H19
24	gastrointestinal stromal tumor	28.7	PIK3CG, PCNA, VIM, VEGFA, ENO2, CCND1
25	leydig cell tumor	28.6	VIM, INSR, ENO2, IGF2, DES, PRL
26	diabetic autonomic neuropathy	28.4	GCG, INS, IGF1, AKR1B1, EPO, GAST
27	polycystic ovary syndrome	28.1	LEP, INS, INSR, IGFBP1, IGF1R, IGF2
28	somatostatinoma	28.1	GCG, CHGA, MEN1, ENO2, GIP, GHRH
29	vlcad deficiency	28.1	PC, PCK2, ACADL, ACADM, ACADVL, CPT1A
30	pancreatic islet cell tumors	28.1	CHGA, INS, MEN1, IGF2, IAPP, GHRH
31	glycogen storage disease type ia	28.1	BTD, LPL, G6PC, G6PC3, SOD1, HGF
32	laron syndrome	28.1	INS, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
33	dumping syndrome	28.1	GCG, SCT, INS, GIP, SST
34	reye syndrome	28.0	PC, HMGCL, ACADM, SLC22A5, HADHA
35	fructose-1,6-bisphosphatase deficiency	28.0	FBP1, PYGL, G6PC, G6PC3
36	3-hydroxyacyl-coenzyme a dehydrogenase deficiency	27.9	HADH, HADHA, HADHB
37	organic acidemia	27.8	PC, BTD, HLCS
38	hyperproinsulinemia	27.8	PCSK1, SCT, INS, IGFBP1
39	silver-russell syndrome	27.8	IGFBP1, IGF1R, IGF2, IGFBP3, IGF1, H19
40	gestational diabetes	27.7	GCK, GCG, KCNJ11, LEP, INS, INSR
41	large cell carcinoma	27.7	CHGA, ENO2, IGF2, IGF1, KRT19, CSF3
42	adrenocortical carcinoma	27.6	CHGA, IGF1R, IGF2, IGFBP2, CYP11B1, CRH
43	carnitine deficiency	27.5	JUN, GLUD1, SLC25A20, SLC22A5, CPT1A, CPT2
44	glucose intolerance	27.5	GCG, CD79A, CCK, HRH2, GHRL, SLC2A2
45	teratoma	27.5	PCNA, GCG, VIM, JUN, ENO2, GIP
46	glycogen storage disease i	27.4	LPL, G6PC, SLC37A4
47	carcinoid syndrome	27.2	VEGFA, CHGA, MEN1, ENO2, IGF1, GHRH
48	hyperprolactinemia	26.9	INS, IL6, IGFBP3, IGF1, GH1, GHRH
49	hypotonia	26.8	PCK2, PCK1, BTD, GLUD1, OTX2, ACSF3
50	erythrocytosis	26.4	IGFBP3, IGF1, F5, ACE, AGT, AGTR1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dextrose, dextrose 100% pwdr [va product], glucagon, glucose, glucose liquid

MalaCards organs/tissues related to hypoglycemia:

²²

MGI Mouse Phenotypes related to hypoglycemia:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	INF	ACADM, ACADL, PDX1, SREBF1, CYP11B1, DUSP1
2	adipose tissue phenotype	MP:0005375	INF	HADHB, NR3C1, CYP11B1, DUSP1, TNF, GHRL
3	endocrine/exocrine gland phenotype	MP:0005379	INF	KCNJ11, SEL1L, , MEN1, GLUD1, GHRH
4	reproductive system phenotype	MP:0005389	INF	LEP, VEGFA, GCGR, , GAL, SLC2A3
5	hematopoietic system phenotype	MP:0005397	INF	FGF2, FOXA2, ATF4, XBP1, P2RX7,
6	immune system phenotype	MP:0005387	INF	P2RX4, CIITA, VIM, , GAST, ADRB2
7	skeleton phenotype	MP:0005390	INF	AKT2, ATF4, P2RX7, LEP, VEGFA, PIK3CG
8	homeostasis/metabolism phenotype	MP:0005376	INF	CACNA1C, GAST, GAL, EPO, H19, HADHB
9	cardiovascular system phenotype	MP:0005385	INF	CACNA1C, EPO, DES, TGFBR3, AGTR2, AGTR1
10	digestive/alimentary phenotype	MP:0005381	INF	NOS2, NOS1, NR3C1, SST, , PDX1
11	renal/urinary system phenotype	MP:0005367	INF	H19, , HADH, , IGFBP2, IGF2R
12	normal phenotype	MP:0002873	INF	SST, , GHRL, HNF4A, AKT2, NR3C1
13	tumorigenesis	MP:0002006	6.6	NOS2, KRT19, ACE, ACADVL, AGTR2, PRL
14	nervous system phenotype	MP:0003631	INF	GHRHR, INSR, INS, FOXA2, FOS, CD36
15	cellular phenotype	MP:0005384	INF	GAL, EPO, HGF, H19, HADH, ADRB2
16	integument phenotype	MP:0010771	INF	CACNA1C, GAL, POMC, CSF3, OPRD1, PRL
17	embryogenesis phenotype	MP:0005380	INF	COMT, KRT19, PRL, SLC2A3, , H19
18	growth/size phenotype	MP:0005378	INF	GHRHR, CCND1, IL6, GRIN1, MEN1, INS
19	respiratory system phenotype	MP:0005388	INF	HCRT, NOS1, CRH, , INSR, GYS1
20	behavior/neurological phenotype	MP:0005386	INF	CACNA1C, GAL, ADRB2, , SLC2A3, SLC2A2
21	mortality/aging	MP:0010768	INF	ATF4, , , GCK, GCG, XBP1
22	no phenotypic analysis	MP:0003012	INF	GHRL, SST, KRT19, OPRD1, POMC, SLC2A1
23	muscle phenotype	MP:0005369	INF	IGF1R, VEGFA, VIM, BTD, , PIK3CG
24	vision/eye phenotype	MP:0005391	INF	IL6, CCND1, IGF2, AKR1B1, TNF,

Articles related to hypoglycemia:

(show top 50)    (show all 448)

id	Title	Authors	Year	Affiliating Genes
1	An activating mutation of AKT2 and human hypoglycemia . (21979934)	Hussain K.... Semple R.K.	2011	AKT2
2	Impact of clinical factors and CYP2C9 variants for th e risk of severe sulfonylurea-induced hypoglycemia. (21213107)	Holstein A.... Stingl J.	2011	CYP2C9
3	ABCC8 mutation allele frequency in the Ashkenazi Jewi sh population and risk of focal hyperinsulinemic hypoglycemia. (21716120)	Glaser B.... Abeliovich D.	2011	ABCC8
4	Diazoxide-responsive hyperinsulinemic hypoglycemia ca used by HNF4A gene mutations. (20164212)	Flanagan S.E.... Ellard S.	2010	GCK, GLUD1, ABCC8
5	Autoimmune forms of hypoglycemia. (19440117)	Lupsa B.C.... Gorden P.	2009	INS
6	A case of retroperitoneal solitary fibrous tumor ass ociated with hypoglycemia (19673425)	Kawashima A.... Kitaoka H.	2009	IGF2
7	Repetitive and profound insulin-induced hypoglycemia results in brain damage in newborn rats: an approach to establish an animal model of brain injury induced by neonatal hypoglycemia. (18205012)	Zhou D.... Sun R.P.	2008	INS
8	Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes. (18328310)	Pedersen-Bjergaard U.... Thorsteinsson B.	2008	ACE, AGTR2, AGTR1
9	Antepartum and intra-partum insulin management of type 1 and type 2 diabetic women: Impact on clinically significant neonatal hypoglycemia. (17126946)	Kline G.A.... Edwards A.	2007	INS
10	Symptomatic hypoglycemia during imatinib mesylate in a non-diabetic female patient with gastrointestinal stromal tumor. (17923802)	Haap M.... Hartmann J.T.	2007	PIK3CG
11	Renal cell carcinoma with non-islet cell tumor hypoglycemia. (16882067)	Fernando H.S.... Musa M.	2006	IGF2
12	Solitary fibrous tumor of the pleura with hypoglycemia associated with serum insulin-like growth factor II. (16935145)	Hirai A.... Nakanishi R.	2006	IGF2
13	Exercise and newer insulins: how much glucose supplem ent to avoid hypoglycemia? (16118572)	DubAc M.C.... Lavoie C.	2005	INS
14	Insulin autoimmunity and hypoglycemia in seven white patients. (15901524)	Basu A.... Eisenbarth G.	2005	INS
15	Low-dose glucose infusion after achieving critical hypoglycemia during insulin tolerance testing: effects on time of hypoglycemia, neuroendocrine stress response and patient's discomfort in a pilot study. (16189173)	Borm K.... Reincke M.	2005	INS
16	Severe hypoglycemia caused by paraneoplastic production of IGF-II in patients with advanced gastrointestinal stromal tumors: a report of two cases. (16170199)	Pink D.... Reichardt P.	2005	IGF2
17	Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes. (15793205)	Rosenstock J.... Salzman A.	2005	INS
18	Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes? (15297801)	Schwab K.O.... Lohse M.J.	2004	ADRB2
19	Severe autoimmune hypoglycemia with insulin antibodies necessitating plasmapheresis. (15251622)	Yaturu S.... Lurie A.	2004	INS
20	Autoimmune hypoglycemia in a type 2 diabetic patient with anti-insulin and insulin receptor antibodies. (15111569)	Sahin M.... Guvener N.D.	2004	INSR
21	Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects. (15334389)	Heise T.... Maggs D.	2004	INS
22	Role of the metabotropic P2Y(4) receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor. (15383322)	Cavaliere F.... Volonte C.	2004	GRIN1, P2RY4
23	Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)	Van Doorn J.... van Buul-Offers S.C.	2002	IGF2
24	Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neur oblastoma cells. (11741009)	Petroni A.... Galli C.	2002	FOS
25	Hunting for a hypoglycemia gene: severe neonatal hypoglycemia in a consanguineous family. (12400064)	Molven A.... vik O.	2002	GCK, GLUD1, ABCC8
26	Effects of morning hypoglycemia on neuroendocrine and metabolic responses to subsequent afternoon hypoglycemia in normal man. (11344204)	Davis S.N.... Tate D.	2001	INS
27	Insulin receptor antibodies inhibit insulin uptake by the liver: in vivo 123I-insulin scintigraphic scanning and in vitro characteri zation in autoimmune hypoglycemia. (11217151)	Dozio N.... Pozza G.	2001	INSR
28	Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy. (10778865)	Taira M.... Tanaka H.	2000	INS
29	Postprandial reactive hypoglycemia. (11119013)	Brun J.F.... Mercier J.	2000	GCG
30	Effects of oral glucose on systemic glucose metabolism during hyperinsulinemic hypoglycemia in normal man. (11145123)	Poulsen P.L.... ller N.	2000	GCG
31	A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland. (10334322)	Otonkoski T.... Thomas P.M.	1999	ABCC8, KCNJ11
32	Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. (10323384)	Service F.J.... Lloyd R.V.	1999	ABCC8, KCNJ11
33	Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy. (10614546)	BaA9 F.... GA1nAPz H.	1999	SST
34	Recurrent hypoglycemia does not impair the cortisol response to adrenocorticotropin infusion in healthy humans. (9781630)	Welt C.K.... Simonson D.C.	1998	POMC
35	Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. (9113474)	Schiel R.... Ulbrich S.	1997	INS
36	Insulin antibodies and hypoglycemia in diabetic patients. Can a quantitative analysis of antibody binding predict the risk of hypoglycemia? (9368685)	Kim M.R.... Gupta M.K.	1997	INS
37	A case of IGF-II producing liver hepatocellular carcinoma with hypoglycemia (9340344)	Inoue R.... Sakata T.	1997	IGF2
38	Severe hypoglycemia secondary to a fibrous pleural tumor (9445586)	Moreno Mata N.... FolquAc GA^mez E.	1997	SST
39	A hypothesis linking hypoglycemia, hyperuricemia, lactic acidemia, and reduced gluconeogenesis in alcoholics to inactivation of glucose-6-phosphatase activity by acetaldehyde. (8949949)	Brecher A.S.... Lehti M.D.	1996	G6PC
40	Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome. (7711161)	Bearn J.... Wessely S.	1995	PRL
41	Improvement of impaired counterregulatory hormone response and symptom perception by short-term avoidance of hypoglycemia in IDDM. (7555474)	Lingenfelser T.... Jakober B.	1995	INS
42	Effects of recent, short-term hyperglycemia on responses to hypoglycemia in humans. Relevance to the pathogenesis of hypoglycemia unawareness and hyperglycemia-induced insulin resistance. (7729608)	Fanelli C.... Bolli G.B.	1995	INS
43	Effect of human galanin on the response of circulating catecholamines to hypoglycemia in man. (8548058)	degli Uberti E.C.... Campo M.	1995	GAL
44	Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide. (7627258)	Owada K.... Omori Y.	1995	GCG, INS
45	Homozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy. (7847376)	Thomas P.M.... Mathew P.M.	1995	ABCC8, KCNJ11
46	Hypoglycemia-induced arginine vasopressin and oxytocin release is mediated by glucoreceptors located inside the blood-brain barrier. (1321355)	Chiodera P.... Coiro V.	1992	OXT
47	Severe hypoglycemia in youth with insulin-dependent diabetes mellitus: frequency and causative factors. (1956736)	Bhatia V.... Wolfsdorf J.I.	1991	INS
48	Insulin resistance and hypoglycemia in a patient with systemic lupus erythematosus: description of antiinsulin receptor antibodies that enhance insulin binding and inhibit insulin action. (1874939)	Di Paolo S.... Giorgino R.	1991	INSR
49	The search for an optimized treatment of hypoglycemia . Carbohydrates in tablets, solutin, or gel for the correction of insulin react ions. (2310277)	Slama G.... Tchobroutsky G.	1990	INS
50	Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (1697583)	Zapf J.... Froesch E.R.	1990	IGFBP3, IGFBP6, IGFBP2

Genes related to hypoglycemia according to GeneCards:

(show top 50)    (show all 137)

id	Symbol	Description	Score	GeneCards Section Context
1	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	11.1	Publications, Summaries
2	GCK	glucokinase (hexokinase 4)	11.1	Publications, Summaries
3	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.1	Publications, Summaries
4	HADH	hydroxyacyl-CoA dehydrogenase	11.1	Summaries, Publications
5	ACADL	acyl-CoA dehydrogenase, long chain	11.0	Publications, Summaries
6	SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	11.0	Summaries, Publications
7	FBP1	fructose-1,6-bisphosphatase 1	11.0	Summaries, Publications
8	GYS2	glycogen synthase 2 (liver)	11.0	Summaries, Publications
9	ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	11.0	Summaries, Publications
10	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Summaries, Publications
11	CRH	corticotropin releasing hormone	11.0	Publications, Summaries
12	PYGL	phosphorylase, glycogen, liver	11.0	Summaries
13	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Summaries
14	INS	insulin	11.0	Publications
15	GLUD1	glutamate dehydrogenase 1	11.0	Publications, Orthologs
16	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)	11.0	Publications
17	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
18	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
19	SST	somatostatin	11.0	Publications
20	INSR	insulin receptor	11.0	Publications
21	SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	11.0	Publications
22	GCG	glucagon	11.0	Functions, Publications, UniProt Related
23	PDX1	pancreatic and duodenal homeobox 1	11.0	Publications
24	KRT19	keratin 19	11.0	Publications
25	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
26	HNF4A	hepatocyte nuclear factor 4, alpha	11.0	Publications
27	VIM	vimentin	11.0	Publications
28	HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	11.0	Publications
29	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
30	GAST	gastrin	11.0	Publications
31	ALG3	asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)	11.0	Publications
32	PPY	pancreatic polypeptide	11.0
33	GLUD2	glutamate dehydrogenase 2	11.0	Orthologs
34	FOXA2	forkhead box A2	11.0	Publications
35	IGFBP6	insulin-like growth factor binding protein 6	11.0	Publications
36	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
37	GCGR	glucagon receptor	11.0	Publications
38	GYS1	glycogen synthase 1 (muscle)	11.0	Publications
39	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	11.0	Publications
40	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	11.0	Publications
41	CPT2	carnitine palmitoyltransferase 2	11.0	Publications
42	OXT	oxytocin, prepropeptide	11.0	Publications
43	IAPP	islet amyloid polypeptide	11.0	Publications
44	MEN1	multiple endocrine neoplasia I	11.0	Publications
45	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
46	AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	11.0	Publications
47	GHRH	growth hormone releasing hormone	11.0	Publications
48	PC	pyruvate carboxylase	11.0	Publications
49	SCT	secretin	11.0	Publications
50	GLP1R	glucagon-like peptide 1 receptor	11.0	Publications

Pathways related to hypoglycemia according to GeneDecks:

(show top 50)    (show all 129)

id	Pathway	Score	Top Affiliating Genes
1	Maturity onset diabetes of the young20	10.9	FOXA2, IAPP, HNF4A, SLC2A2, PDX1, GCK
2	Glucose / Energy Metabolism3	10.8	IGF1R, IGFBP2, SLC2A4, GLUD1, GCG, ENO2
3	Type II diabetes mellitus20	10.7	GCK, KCNJ11, INS, CACNA1C, SLC2A2, SLC2A4
4	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	10.5	PDX1, CACNA1C, SLC2A2, PIK3CG, ABCC8, GCK
5	MODY (Maturity-Onset Diabetes of Young)36	10.5	INSR, CACNA1C, GCK, FOXA2, IGF1R, HNF4A
6	Transcription Receptor-mediated HIF regulation10	10.4	IGF1R, INS, INSR, AKT2, IGF1, IGFBP3
7	Development IGF-RI signaling10	10.3	IGFBP2, IGFBP6, IGF1, IGFBP3, IGF2, IGF1R
8	Development_IGF-1 receptor signaling41	10.3	IGFBP2, CCND1, IGF1, GYS1, IGFBP6, IGFBP3
9	Selected targets of HNF110	10.3	SLC2A2, INS, IGFBP1, IAPP, ALB, PDX1
10	HIF1Alpha Pathway36	10.2	SLC2A4, SLC2A3, SLC2A2, SLC2A1, HNF4A, JUN
11	Adipocytokines & Insulin Signaling37	10.1	LEP, SLC2A4, PIK3CG, INSR, FOS, GYS1
12	Transcription_Receptor-mediated HIF regulation41	9.9	INS, INSR, IGF1R, IGFBP3, IGF1, AKT2
13	ILK Signaling36	9.8	HNF4A, ATF4, JUN, FOS, INSR, IGF1R
14	Telomerase Components in Cell Signaling36	9.7	HGF, GHRH, GH1, IGF1, IGF2R, IGF1R
15	ERK5 Signaling36	9.6	GH1, IGF2, IL6, FOS, BDNF, GHRH
16	Activation of cAMP-Dependent PKA36	9.6	CACNA1C, IGF2, IGF1, GH1, GYS1, GHRH
17	Activation of PKA through GPCR36	9.5	GCGR, IL6, FGF2, GCG, INSR, BDNF
18	Neuroactive ligand-receptor interaction20	9.5	GLP1R, GRIN1, P2RY4, P2RX7, P2RX4, LEP
19	NFAT in Immune Response36	9.4	IGF1, IGF2, IGF1R, FGF2, INSR, FOS
20	eIF2 Pathway36	9.4	IL6, FGF2, INSR, IGF1, INS, GH1
21	p70S6K Signaling36	9.3	IGF1, GH1, TGFBR3, HGF, GHRH, IGF1R
22	p53 Mediated Apoptosis36	9.3	HGF, IL6, IGF2R, FGF2, IGF1R, IGF2
23	14-3-3 Induced Intracellular Signaling36	9.2	IGF1, FGF2, IGF1R, INSR, GH1, GHRH
24	Selected targets of GCR-alpha10	9.2	LEP, DUSP1, HSP90B1, IGFBP1, IL6, IL1B
25	Nuclear Receptor Activation by Vitamin-A36	9.0	IGF2R, IGF1R, IL6, FGF2, ATF4, BDNF
26	DHA Signaling36	9.0	BDNF, HGF, GHRH, TGFBR3, GH1, AKT2
27	cAMP Pathway36	8.9	GYS1, GYS2, ATF4, PYGL, PHKB, TGFBR3
28	ERK Signaling36	8.8	CSF3, ATF4, CACNA1C, DUSP1, GHRH, IL6
29	PPAR Pathway36	8.8	TGFBR3, TNF, GH1, IGF1, IGF2, IGF1R
30	Rho Family GTPases36	8.7	JUN, GH1, BDNF, HGF, CSF3, DES
31	Akt Signaling36	8.7	GYS2, ATF4, CCND1, IGF1R, TNF, SLC2A4
32	Estrogen Pathway36	8.6	FGF2, ATF4, JUN, FOS, CCND1, IGF1R
33	Renin-Angiotensin Pathway36	8.6	AGTR2, TGFBR3, HGF, AGTR1, JUN, AGT
34	Apoptotic Pathways in Synovial Fibroblasts36	8.6	GH1, IGF1, IGF2, BDNF, IGF2R, IL6
35	Intracellular Calcium Signaling36	8.6	GRIN1, BDNF, P2RX4, P2RX7, ATF4, INSR
36	Cellular Apoptosis Pathway36	8.4	GHRH, HGF, TNF, GH1, TGFBR3, BDNF
37	JAK-STAT Pathway36	8.2	IGF1, IGF2, AKT2, GHRH, IGF1R, JUN
38	MAPK Signaling36	7.8	IGF1R, IL1B, FGF2, INSR, IL6, GHRH
39	PAK Pathway36	7.7	CSF3, TGFBR3, GHRH, GH1, IGF1, IGF2
40	Antioxidant Action of Vitamin-C36	7.6	FGF2, IL6, SLC2A4, CSF3, TNF, GHRH
41	PPAR signaling pathway20	INF	, ACADM, CPT1A, CPT2, CD36,
42	Glycolysis and gluconeogenesis (short map)10	INF	, SLC2A4, G6PC, FBP1, , GCK
43	Glycolysis and gluconeogenesis (short map)41	INF	, PC, GCK, PCK2, FBP1, ENO2
44	Adipocytokine signaling pathway20	INF	PCK2, SLC2A1, SLC2A4, NPY, POMC, G6PC
45	Glucose transport38	INF	GCK, , SLC2A3, SLC2A2, SLC2A1, SLC2A4
46	Glucose metabolism38	INF	, PC, PCK2, GYG2, GYS1, GYS2
47	Fatty acid metabolism20	INF	ACADL, CPT2, HADHB, , CPT1A, ACADVL
48	Selected targets of CREB110	INF	CHGA, SLC2A3, SLC2A1, CRH, IAPP, CCK
49	Metabolic pathways20	INF	FBP1, GLUD1, COMT, NOS1, CYP2C9, CYP11B1
50	Insulin signaling pathway20	INF	AKT2, PYGL, SREBF1, PHKB, G6PC, SLC2A4

Compounds related to hypoglycemia according to GeneDecks:

(show top 50)    (show all 536)

id	Compound	Score	Top Affiliating Genes
1	adenylate32	INF	PIK3CG, , GCK, GCG, GCGR, VIM
2	glucose32	INF	PC, , GCG, GCGR, BTD, KCNJ11
3	glycogen32 18	INF	PIK3CG, PC, PCK2, , GCK, GCG
4	glycerol32 9 18 9	INF	PC, PCK2, PCNA, , GCK, GCG
5	calcium32 9 18 9	INF	, GCK, GCGR, BDNF, KCNJ11, SCT
6	creatinine32	INF	PCNA, GCK, GCG, BDNF, CKB, LEP
7	atp32	INF	PC, PCK2, GCK, GCGR, BDNF, KCNJ11
8	rosiglitazone32 9 18 9	INF	PIK3CG, PCK2, , LPL, LEP, JUN
9	glimepiride32 34 9 9	13.7	GCG, KCNJ11, KCNJ5, INS, INSR, CYP2C9
10	sulfonylurea32	10.5	GCK, GCG, KCNJ11, KCNJ5, IAPP, GLP1R
11	2-deoxyglucose32	10.2	PIK3CG, GCK, XBP1, FOS, INS, INSR
12	pirenzepine32 9 9	12.1	GCG, CCK, IGFBP1, IGF1, HRH2, GH1
13	pyridostigmine32 9 9	12.0	IGFBP1, IGFBP3, IGF1, GH1, GHRH, GHRL
14	chloramphenicol32 9 9	11.9	PCK2, VIM, LPL, CHGA, JUN, FOS
15	opiate32	9.9	CCK, IAPP, HRH2, GH1, GHRH, GHRL
16	dhea32	9.8	LEP, INS, IGFBP1, IGF2, IGFBP2, IGFBP3
17	triiodothyronine32	9.7	PCK2, LEP, IGFBP1, IGF2, IGFBP3, IGF1
18	estradiol32 9 18 9	12.6	PCNA, VIM, BDNF, CCND1, IGFBP6, IGFBP1
19	octreotide32 42 9 9	12.6	GCG, VEGFA, SCT, CHGA, INS, INSR
20	n acetylcysteine32	9.5	PCNA, BDNF, ATF4, CD79A, FOS, CCND1
21	pioglitazone32 9 9	11.5	GCG, VEGFA, LPL, LEP, JUN, INS
22	sodium32 18	10.4	BDNF, SCT, CKB, P2RX7, ENO2, ALB
23	dopamine32 9 18 9	12.3	GCG, BDNF, KCNJ5, SCT, CIITA, CD79A
24	dihydrotestosterone32 9 18 9	12.0	VIM, LPL, LEP, CD79A, INSR, FGF2
25	cocaine32 9 9	11.0	GCG, VIM, BDNF, LEP, FOS, GRIN1
26	calcitriol32 42 9 18 9	12.9	JUN, CD36, FOS, FGF2, IGFBP1, IGF1R
27	thyroxine32 18	9.6	PCNA, LPL, SCT, LEP, CIITA, CD79A
28	testosterone32 9 18 9	11.4	PCNA, VIM, LPL, BDNF, KCNJ5, SCT
29	oxygen32 18	9.3	GCK, BDNF, KCNJ5, CKB, CIITA, P2RX4
30	acetylcholine32 9 18 9	11.3	GCG, VIM, LPL, BDNF, KCNJ5, SCT
31	losartan32 34 9 9	11.2	PCNA, LEP, CD36, FOS, IGFBP3, IGF1
32	paraffin32	8.0	PCNA, VIM, VEGFA, LEP, CHGA, CD79A
33	methotrexate32 34 42 9 9	11.1	PCNA, VIM, LEP, CD79A, IL1B, IL6
34	superoxide32 18	8.1	PC, KCNJ5, P2RX7, IL1B, ENO2, IGF1R
35	hydrocortisone32 9 9	9.0	VIM, CD36, INS, INSR, FGF2, IL1B
36	nitric oxide32 9 18 9	9.2	GCK, KCNJ5, CIITA, CHGA, GRIN1, IL1B
37	pd 98,05932	6.1	PIK3CG, PCK2, GCG, BDNF, SCT, LEP
38	actinomycin d32	5.3	PIK3CG, VIM, VEGFA, BDNF, CIITA, JUN
39	cysteine32	INF	PCK2, PCNA, GCK, GCG, BTD, SCT
40	acyl-coa32	INF	PC, PCK2, BTD, LPL, GLUD1, HNF4A
41	gnrh32	INF	, GCG, VIM, LEP, INS, IGFBP1
42	leucine32	INF	PCK2, GCK, VIM, KCNJ11, CIITA, XBP1
43	c-peptide32	INF	, GCK, GCG, KCNJ11, SCT, LEP
44	ribonucleic acid32	INF	, CIITA, CHGA, FOS, GRIN1, IL1B
45	phosphoenolpyruvate32 9 9	INF	PC, PCK2, , GCK, ENO2, IGFBP1
46	ibmx32	INF	PCK2, , GCG, LPL, BDNF, SCT
47	alanine32	INF	PC, PCK2, PCNA, GCK, GCG, BTD
48	pyruvate32	INF	PC, PCK2, GCK, CKB, , HSPA5
49	lactate32	INF	PC, PCK2, PCNA, GCK, GCG, BTD
50	phosphoinositide32	INF	PIK3CG, VIM, BDNF, XBP1, JUN, FOS

Cellular components related to hypoglycemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	COMT, NOS2, NOS1, NR3C1, PYGL,
2	terminal button	GO:043195	10.2	GHRH, CCK, GRIN1, P2RX7, OXT
3	extracellular region	GO:005576	6.2	GCG, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
4	secretory granule	GO:030141	INF	CHGA, INS, IL1B, GIP, GHRHR, GHRL
5	extracellular space	GO:005615	INF	INS, ALB, AKR1B1, GH1, GHRH, GHRL
6	plasma membrane	GO:005886	INF	AGTR2, AGTR1, ACE, ABCC8, PHKB, COMT
7	mitochondrial matrix	GO:005759	INF	ACADVL, , SOD1, SOD2, HADH, ACADM
8	mitochondrial inner membrane	GO:005743	INF	HADHB, , HADH, CPT2, CPT1A, SLC25A20
9	mitochondrion	GO:005739	INF	, SOD1, SOD2, SLC16A1, SLC25A20, CPT1A

Biological processes related to hypoglycemia according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	gluconeogenesis	GO:006094	INF	G6PC3, G6PC, , ENO2, FBP1, ATF4
2	cellular response to insulin stimulus	GO:032869	INF	SLC2A4, , GHRHR, AKT2, , FBP1
3	cellular lipid metabolic process	GO:044255	INF	SLC25A20, CPT1A, CPT2, HADH, , HADHB
4	response to glucocorticoid stimulus	GO:051384	INF	GHRHR, TNF, DUSP1, AGL, OXT,
5	glucose homeostasis	GO:042593	INF	PDX1, G6PC, SLC2A4, , CYP11B1, PYGL
6	positive regulation of glycogen biosynthetic process	GO:045725	10.9	AKT2, IGF1, IGF2, INSR, INS, GCK
7	glycogen biosynthetic process	GO:005978	10.7	AGL, AKT2, GYS2, GYS1, GYG2, GCK
8	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.7	GHRHR, GHRH, GH1, IGF1, IGFBP3
9	positive regulation of insulin secretion	GO:032024	10.6	TRH, GHRL, GIP, GLUD1, GLP1R, GCK
10	exocrine pancreas development	GO:031017	10.6	PDX1, IGF1, INSR, XBP1
11	feeding behavior	GO:007631	10.6	GAL, NPY, CRH, GLP1R, BDNF, GCG
12	endocrine pancreas development	GO:031018	10.4	SLC2A2, PDX1, GIP, HNF4A, IAPP, IL6
13	glycogen catabolic process	GO:005980	10.2	AGL, G6PC, PHKB, PYGL, GYG2
14	eating behavior	GO:042755	10.2	CPT1A, OXT, HCRT, TRH, CCK, LEP
15	positive regulation of prostaglandin secretion	GO:032308	10.2	OXT, IL1B, P2RX7, P2RX4
16	positive regulation of multicellular organism growth	GO:040018	10.2	GH1, GHRH, GHRHR, GHRL, AGT
17	positive regulation of DNA replication	GO:045740	10.1	EPO, IGF1, IGF1R, INSR, INS, JUN
18	growth hormone secretion	GO:030252	10.0	GAL, GHRL, GHRHR, GHRH
19	elevation of cytosolic calcium ion concentration	GO:007204	10.0	CACNA1C, OXT, AGTR1, HCRT, GHRL, GHRH
20	positive regulation of mitosis	GO:045840	9.7	TNF, IGF1, IGF2, IL1B, INSR, INS
21	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	AGTR2, TNF, IL1B, INSR, INS, P2RX4
22	positive regulation of MAPK cascade	GO:043410	9.4	ADRB2, AGT, IGF1, IGFBP3, IGF2, IL6
23	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	IGF1, GH1, AGT, HGF, IGF2, CCK
24	regulation of blood pressure	GO:008217	9.3	NPPB, POMC, SOD2, SOD1, AGTR2, ACE
25	platelet degranulation	GO:002576	9.0	HGF, SOD1, HSPA5, ALB, F5, IGF1
26	signal transduction	GO:007165	8.6	AKT2, GIP, TRH, NR3C1, NR3C2, CRH
27	positive regulation of apoptotic process	GO:043065	8.6	AGT, AGTR2, SOD1, ADRB2, GAL, DUSP1
28	positive regulation of cell proliferation	GO:008284	8.4	GLP1R, GHRH, GHRHR, PDX1, DPP4, CSF3
29	anti-apoptosis	GO:006916	8.4	TNF, NR3C1, SOD1, HGF, EPO, GHRL
30	response to hypoxia	GO:001666	8.3	NPPB, DPP4, TGFBR3, NOS2, NOS1, TNF
31	negative regulation of cell proliferation	GO:008285	8.2	SOD2, AGT, PDX1, SST, TNF, HNF4A
32	activation of MAPK activity	GO:000187	8.2	HGF, SOD1, TNF, GHRL, IL1B, FGF2
33	negative regulation of apoptotic process	GO:043066	7.9	HSPA5, GLP1R, GHRL, TNF, SOD2, EPO
34	glucose metabolic process	GO:006006	INF	PC, PCK2, , KCNJ11, LEP, CPT1A
35	response to glucose stimulus	GO:009749	INF	GYS2, INSR, GLP1R, HNF4A, GIP, TRH
36	glucose transport	GO:015758	INF	, SLC2A3, SLC2A2, SLC2A1, SLC2A4, G6PC3
37	response to insulin stimulus	GO:032868	INF	GGH, GAL, HADH, NR3C1, GHRHR, FOXA2
38	response to organic cyclic compound	GO:014070	INF	CPT1A, NPPB, COMT, TRH, GIP,
39	response to activity	GO:014823	INF	HADH, OXT, NR3C1, TNF, INSR,
40	small molecule metabolic process	GO:044281	INF	PIK3CG, , GLP1R, GLUD1, AKR1B1,
41	positive regulation of transcription, DNA-dependent	GO:045893	INF	HNF4A, GHRH, TNF, , AGT, AGTR2
42	liver development	GO:001889	INF	HGF, JUN, CCND1, , ,
43	response to ethanol	GO:045471	INF	GGH, SLC2A4, SOD1, TRH, , CCND1
44	fatty acid beta-oxidation	GO:006635	INF	HADHB, , HADH, CPT2, CPT1A, ACADVL
45	carbohydrate metabolic process	GO:005975	INF	G6PC, G6PC3, AGL, SLC2A4, SLC2A1, SLC2A2
46	energy reserve metabolic process	GO:006112	INF	CACNA1C, SLC2A2, SLC2A1, ABCC8, GIP, GLP1R
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	GLP1R, HNF4A, TNF, , SREBF1, NOS1
48	regulation of insulin secretion	GO:050796	INF	GCK, GCG, KCNJ11, LEP, INS, IL1B
49	hexose transport	GO:008645	INF	, SLC2A3, SLC2A2, SLC2A1, SLC2A4, G6PC3
50	response to drug	GO:042493	INF	HNF4A, GIP, , TNF, SST, COMT

Molecular functions related to hypoglycemia according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	SREBF1, NR3C1, NR3C2, CRH, NOS1, NOS2
2	insulin-like growth factor I binding	GO:031994	10.6	IGFBP3, IGFBP2, IGF1R, IGFBP6, INSR
3	insulin-like growth factor II binding	GO:031995	10.6	IGFBP3, IGFBP2, INSR
4	D-glucose transmembrane transporter activity	GO:055056	10.5	SLC2A2, SLC2A1, SLC2A4
5	insulin receptor binding	GO:005158	10.5	SLC2A2, IGF1, IGF2, IGF1R, INS
6	neuropeptide hormone activity	GO:005184	10.4	GAL, NPY, HCRT, CRH, TRH, CCK
7	insulin-like growth factor receptor binding	GO:005159	10.4	INS, INSR, IGF2, IGF1
8	hormone activity	GO:005179	9.6	GCG, PPY, CRH, AGT, PRL, POMC
9	growth factor activity	GO:008083	8.0	HGF, CSF3, AGT, GH1, IGF1, IGF2
10	fatty-acyl-CoA binding	GO:000062	INF	HADHB, ACADL, , HNF4A
11	receptor binding	GO:005102	INF	CRH, NOS2, DPP4, POMC, NPPB, NPY
12	protein homodimerization activity	GO:042803	INF	NR3C1, NOS2, DPP4, SOD1, ADRB2, HLCS
13	insulin binding	GO:043559	INF	, INSR, IGF1R