Hypoglycemic Coma malady

MalaCards: Hypoglycemic Coma, also known as hypoglycemic coma nos (disorder), is related to cerebral hemorrhage and anorexia nervosa. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways is p70S6K Signaling. The compounds levonorgestrel and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include brain and breast.

Aliases & Descriptions:

hypoglycemic coma 6 8 32 43 hypoglycemic coma nos (disorder) 6

hypoglycemic coma (disorder) 6 hypoglycaemic coma 6

Diseases related to hypoglycemic coma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 94)

id	Related Disease	Score	Top Affiliating Genes
1	cerebral hemorrhage	29.5	INS, F2
2	anorexia nervosa	28.8	F2, IGF2, INS
3	fetal macrosomia	12.8	INS, IGF2
4	laron syndrome	12.8	INS, IGF2
5	hypoglycemia of infancy	12.8	INS, IGF2
6	persistent hyperinsulinemic hypoglycemia of infancy	12.8	IGF2, INS
7	costello syndrome	12.8	INS, IGF2
8	neonatal diabetes mellitus	12.8	F2, INS
9	nephrosclerosis	12.8	INS, F2
10	polycystic ovary syndrome	12.8	INS, IGF2
11	rickets	12.8	INS, F2
12	hyperinsulinemic hypoglycemia	12.8	IGF2, INS
13	androgen insensitivity syndrome	12.8	INS, IGF2
14	pancreatic islet cell tumors	12.8	IGF2, INS
15	adrenal adenoma	12.8	IGF2, INS
16	ileus	12.8	INS, F2
17	virilization	12.8	INS, IGF2
18	peripheral vascular disease	12.8	INS, F2
19	head injury	12.8	F2, INS
20	ovarian hyperstimulation syndrome	12.8	INS, F2
21	alcoholic liver cirrhosis	12.8	F2, INS
22	pulmonary embolism	12.8	F2, INS
23	cholelithiasis	12.8	INS, F2
24	pulmonary edema	12.8	INS, F2
25	biliary atresia	12.8	F2, IGF2
26	beckwith-wiedemann syndrome	12.8	IGF2, INS
27	nonalcoholic steatohepatitis	12.8	INS, F2
28	hemolytic-uremic syndrome	12.8	INS, F2
29	myostatin-related muscle hypertrophy	12.8	IGF2, INS
30	portal hypertension	12.8	INS, F2
31	nephrolithiasis	12.8	INS, F2
32	hyperandrogenism	12.7	INS, IGF2
33	addison's disease	12.7	INS, F2
34	pulmonary function	12.7	F2, INS
35	familial hypercholesterolemia	12.7	F2, INS
36	cork-handlers' disease	12.7	F2, INS
37	premature ovarian failure	12.7	INS, IGF2
38	primary hyperoxaluria	12.7	F2, INS
39	lactic acidosis	12.7	INS, F2
40	histiocytosis	12.7	F2, INS
41	iron overload	12.7	INS, F2
42	chronic fatigue syndrome	12.7	IGF2, INS
43	bannayan-riley-ruvalcaba syndrome	12.7	INS, IGF2
44	proliferative diabetic retinopathy	12.7	INS, IGF2
45	respiratory failure	12.7	INS, F2
46	obesity, association with	12.6	IGF2, INS
47	beta thalassemia	12.6	INS, F2
48	hyperhomocysteinemia	12.6	F2, INS
49	acromegaly	12.6	INS, IGF2
50	acquired immunodeficiency syndrome	12.6	INS, F2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypoglycemic coma:

²²

Articles related to hypoglycemic coma:

id	Title	Authors	Year	Affiliating Genes
1	Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. (17319862)	Aguiar Bujanda D.... Le Bouc Y.	2007	IGF2
2	Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)	Ma W.Y.... Lin H.D.	2005	INS
3	Hypoglycemic coma revealing a solitary fibrous tumor of the pleura (16292188)	Kafih M.... Zerouali N.O.	2005	IGF2
4	Drug-induced hypoglycemic coma in 102 diabetic patients. (9989540)	Ben-Ami H.... Edoute Y.	1999	INS
5	Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. (9836523)	Kramer L.... Grimm G.	1998	INS
6	Hypoglycemic coma associated with brain infarcts. (17895073)	Chinnapongse R.B.... Johnson R.J.	1998	INS
7	Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)	Yamada Y.... Kameyama M.	1996	F2
8	Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)	Burch H.B.... Landry F.	1992	INS
9	Increasing incidence of hypoglycemic coma in children with IDDM. (1797479)	Egger M.... Zuppinger K.	1991	INS

Genes related to hypoglycemic coma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
2	INS	insulin	11.0	Publications
3	GBP3	guanylate binding protein 3	11.0
4	F2	coagulation factor II (thrombin)	11.0	Publications

Pathways related to hypoglycemic coma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	p70S6K Signaling36	8.8	INS, IGF2, F2

Compounds related to hypoglycemic coma according to GeneDecks:

(show all 20)

id	Compound	Score	Top Affiliating Genes
1	levonorgestrel32 9 9	11.8	IGF2, F2
2	desogestrel32 9 9	11.7	INS, F2
3	cyproteroneacetate32	9.7	INS, F2
4	protamine32	9.6	INS, F2
5	dehydroepiandrosterone sulfate32	9.6	IGF2, INS
6	nicotinamide32 9 9	11.6	INS, IGF2
7	2-deoxyglucose32	9.6	INS, IGF2
8	octreotide32 42 9 9	12.6	IGF2, INS
9	aprotinin32 9 9	11.6	IGF2, F2
10	c-peptide32	9.6	INS, IGF2
11	dhea32	9.6	IGF2, INS
12	pioglitazone32 9 9	11.5	INS, IGF2
13	androstenedione32 18	10.5	INS, IGF2
14	polyethylene glycol32	9.5	F2, IGF2
15	carnitine32	9.4	IGF2, INS
16	suramin32 9 9	11.4	IGF2, F2
17	ibmx32	9.3	INS, IGF2
18	lactate32	9.1	F2, IGF2, INS
19	hydrocortisone32 9 9	11.0	INS, IGF2
20	alanine32	8.7	F2, IGF2, INS

Cellular components related to hypoglycemic coma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	9.0	INS, F2
2	extracellular space	GO:005615	8.8	INS, IGF2, F2

Biological processes related to hypoglycemic coma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of insulin receptor signaling pathway	GO:046628	9.6	INS, IGF2
2	positive regulation of glycogen biosynthetic process	GO:045725	9.6	INS, IGF2
3	negative regulation of proteolysis	GO:045861	9.6	INS, F2
4	positive regulation of mitosis	GO:045840	9.6	IGF2, INS
5	acute-phase response	GO:006953	9.5	INS, F2
6	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	F2, INS
7	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	INS, IGF2
8	positive regulation of MAPK cascade	GO:043410	9.4	INS, IGF2
9	glucose metabolic process	GO:006006	9.3	INS, IGF2
10	positive regulation of cell growth	GO:030307	9.3	F2, INS
11	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	INS, IGF2
12	positive regulation of protein phosphorylation	GO:001934	9.1	IGF2, F2
13	positive regulation of cell proliferation	GO:008284	9.0	INS, IGF2, F2

Molecular functions related to hypoglycemic coma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	9.3	INS, IGF2
2	insulin-like growth factor receptor binding	GO:005159	9.2	INS, IGF2
3	insulin receptor binding	GO:005158	9.0	INS, IGF2