MCID: HYP026
MIFTS: 43

Hypoglycemic Coma malady

Summaries for Hypoglycemic Coma

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33MalaCards
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MalaCards: Hypoglycemic Coma, also known as hypoglycemic coma nos, is related to hepatitis c and hypoglycemia. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Asparagine N-linked glycosylation and SHC-mediated signalling. The compounds aprotinin and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are skeleton and cardiovascular system.

Aliases & Classifications for Hypoglycemic Coma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

hypoglycemic coma 8 10 45 61
hypoglycemic coma nos 8
hypoglycaemic coma 8


External Ids:

Disease Ontology8 DOID:1607
ICD9CM27 251.0

Related Diseases for Hypoglycemic Coma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.4F2
2hypoglycemia30.4IGF2, INS
3anorexia nervosa10.4
4solitary fibrous tumor10.4
5insulin autoimmune syndrome10.3
6mucinous cystadenocarcinoma10.2
7appendix mucinous cystadenocarcinoma10.2
8sheehan syndrome10.2
9normal pressure hydrocephalus10.1
10diabetic ketoacidosis10.1
11benign pleural mesothelioma10.1
12central pontine myelinolysis10.1
13silent myocardial infarction10.1
14insulinoma10.1
15hepatitis a10.1
16benign mesothelioma10.1
17medium-chain acyl-coenzyme a dehydrogenase deficiency10.1
18isolated acth deficiency10.1
19acth deficiency10.1
20hepatitis c virus10.1
21brain ischemia10.1
22phyllode tumor10.1
23laron syndrome10.0IGF2
24hepatoblastoma10.0IGF2
25peripheral vascular disease10.0INS
26ovarian hyperstimulation syndrome10.0VEGFA
27coronary heart disease10.0INS
28proliferative diabetic retinopathy10.0VEGFA
29infertility10.0INS
30osteosclerosis10.0IGF2
31cystic fibrosis10.0INS
32hemangioma10.0VEGFA
33morbid obesity10.0INS
34central retinal vein occlusion10.0VEGFA
35wilms tumor10.0IGF2
36hypercholesterolemia10.0INS
37adrenal adenoma10.0IGF2
38ischemia10.0VEGFA
39choriocarcinoma10.0IGF2
40diabetic macular edema10.0VEGFA
41diarrhea10.0INS
42neonatal diabetes mellitus10.0INS
43myeloma10.0VEGFA
44hemangiopericytoma10.0IGF2
45hypothyroidism10.0INS
46rhabdomyosarcoma10.0IGF2
47atherosclerosis10.0INS
48colon adenocarcinoma10.0IGF2
49hyperinsulinemic hypoglycemia10.0INS
50smooth muscle tumor10.0IGF2

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Clinical Features for Hypoglycemic Coma

Drugs & Therapeutics for Hypoglycemic Coma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hypoglycemic Coma

Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Search CenterWatch for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

Anatomical Context for Hypoglycemic Coma

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypoglycemic Coma:

33
Brain, Heart, Liver, Breast, Endothelial, Fetal brain, Temporal lobe, Fetal liver

Animal Models for Hypoglycemic Coma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hypoglycemic Coma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7VEGFA
2MP:00053858.9IGF2, INS, F2
3MP:00053818.2IGF2, F2, INS, VEGFA
4MP:00107718.1F2, VEGFA, INS, IGF2
5MP:00053808.0VEGFA, INS, F2, IGF2
6MP:00053897.8F2, INS, IGF2, VEGFA

Publications for Hypoglycemic Coma

Sources:
51PubMed
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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy. (24097322)
2013
2
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. (21056562)
2011
3
Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. (21439874)
2011
4
Bilateral posterior shoulder dislocation with defect secondary to hypoglycemic coma. (21246228)
2011
5
Hypoglycemic coma in a patient with anorexia nervosa coincident with acute exacerbation of liver injury induced by oral intake of nutrients. (20686290)
2010
6
The influence of hypoglycemia on cerebral blood flow in cases of hypoglycemic coma. (19305083)
2009
7
Truncation of the krebs cycle during hypoglycemic coma. (18673151)
2008
8
Extensive white matter injury in hypoglycemic coma. (17389314)
2007
9
The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma. (17317199)
2007
10
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
11
Malignant solitary fibrous tumor of the thigh accompanied by hypoglycemic coma. A case report. (16080476)
2005
12
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. (15098777)
2004
13
Hypoglycemic coma in a pregnant woman in association with hepatitis B virus carrier state and hepatocellular carcinoma. (14745290)
2004
14
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. (12971357)
2003
15
Reversible hypoglycemic coma despite bilateral absence of the median nerve N20 evoked potential. (12771284)
2003
16
Bispectral index monitoring during hypoglycemic coma. (12088817)
2002
17
Protein ubiquitination in rat brain following hypoglycemic coma. (11165431)
2001
18
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets. (11412899)
2001
19
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. (11083229)
2000
20
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. (10973608)
2000
21
Is neuronal injury caused by hypoglycemic coma of the necrotic or apoptotic type? (10905628)
2000
22
Hypoglycemic coma masquerading thyrotoxic storm. (10563748)
1999
23
Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. (7750077)
1995
24
Increasing incidence of hypoglycemic coma in children with IDDM. (1797479)
1991
25
Extracellular pH in the rat brain during hypoglycemic coma and recovery. (2303542)
1990
26
Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. (2719056)
1989
27
Insulinoma complicating pregnancy presenting with hypoglycemic coma after delivery: a case report and review of the literature. (2539573)
1989
28
Electrolyte shifts between brain and plasma in hypoglycemic coma. (3693435)
1987
29
Beta-hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels. (3334063)
1986
30
Insulin-induced factitious hypoglycemic coma. (3527869)
1986
31
gamma-Aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis. (4088534)
1985
32
Hypoglycemic coma after cardiac surgery. (6705551)
1984
33
Hypoglycemic coma due to disopyramide toxicity. (6635745)
1983
34
Hypoglycemic coma associated with CSII. (6872815)
1983
35
Neurophysiological recovery after hypoglycemic coma in the rat: correlation with cerebral metabolism. (6822622)
1983
36
Ethanol-induced hypoglycemic coma in a child. (7073036)
1982
37
Hypoglycemic coma due to use of an improper battery in a commonly used insulin pump. (6927734)
1982
38
Hypoglycemic coma: don't overlook acute adrenal crisis. (6279471)
1982
39
Insulin-induced hypoglycemic coma and regional cerebral energy metabolism. (7020876)
1981
40
Hypoglycemic coma associated with subcutaneous insulin infusion by portable pump. (7047116)
1981
41
Hypoglycemic coma with ketoacidosis in nondiabetic alcoholics. (506212)
1979
42
Hypoglycemic coma associated with benign pleural mesothelioma. (1113546)
1975
43
Jaundice in pregnancy (a case report of infective hepatitis in pregnancy with hypofibrinogenenia and hypoglycemic coma). (4457638)
1974
44
Cerebral metabolism in schizophrenia. Study on L-(U- 14 C) glutamine and L-(U- 14 C) glutamic acid under basal conditions and in hypoglycemic coma. (5022651)
1972
45
Cerebrospinal fluid pleocytosis in hypoglycemic coma. (5658451)
1968
46
Alcohol and hypoglycemic coma. (5695588)
1968
47
HYPOGLYCEMIC COMA DURING SULFONYLUREA THERAPY. (14281786)
1965
48
Two cases of malignant tumors with metastases apparently treated successfully with hypoglycemic coma. (14458502)
1962
49
Hypoglycemic coma following BZ 55; report of a case. (13640693)
1959
50
An investigation of the role played by oxygen and by cellular respiration in hypoglycemic coma. (13323105)
1956

Genetic Variations for Hypoglycemic Coma

Expression for genes affiliated with Hypoglycemic Coma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for genes affiliated with Hypoglycemic Coma

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Hypoglycemic Coma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1aprotinin45 1111.0IGF2
2heparin45 29 11 2412.9VEGFA
3dehydroepiandrosterone sulfate459.8INS, IGF2
4nicotinamide45 1110.8IGF2, INS
5levonorgestrel45 60 29 1112.7F2, IGF2
62-deoxyglucose45 1110.7INS, IGF2
7desogestrel45 1110.7F2, INS
8c-peptide459.7IGF2, INS
9cyproteroneacetate459.7INS, F2
10dhea459.7INS, IGF2
11protamine459.6F2, INS
12androstenedione45 2410.6IGF2, INS
13leucovorin45 50 1111.5IGF2, VEGFA
14gliclazide45 50 1111.5INS, VEGFA
15carnitine459.5INS, IGF2
16irinotecan45 50 1111.3IGF2, VEGFA
17silymarin459.3VEGFA, F2
18gefitinib45 50 1111.3IGF2, VEGFA
19lactate459.2F2, INS, IGF2
20creatinine459.1F2, INS, IGF2
21polyethylene glycol459.1F2, IGF2
22progestin459.1IGF2, VEGFA
23octreotide45 60 29 1112.1INS, IGF2, VEGFA
24pioglitazone45 50 29 1112.1INS, IGF2, VEGFA
25rapamycin459.0VEGFA, IGF2, INS
26ly294002459.0INS, IGF2, VEGFA
27suramin45 29 1111.0VEGFA, IGF2, F2
28tamoxifen45 50 29 1111.9F2, IGF2, VEGFA
29estrogen458.4VEGFA, IGF2, INS, F2

GO Terms for genes affiliated with Hypoglycemic Coma

Sources:
16Gene Ontology
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Cellular components related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3F2, INS
2platelet alpha granule lumenGO:0310939.1IGF2, VEGFA
3extracellular spaceGO:0056158.1F2, INS, IGF2, VEGFA
4extracellular regionGO:0055767.8VEGFA, IGF2, INS, F2

Biological processes related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:0466289.8IGF2, INS
2positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF2
3positive regulation of mitosisGO:0458409.7IGF2, INS
4negative regulation of proteolysisGO:0458619.6F2, INS
5positive regulation of MAPK cascadeGO:0434109.6IGF2, INS
6acute-phase responseGO:0069539.5F2, INS
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5F2, INS
8positive regulation of protein autophosphorylationGO:0319549.4INS, VEGFA
9positive regulation of protein kinase B signaling cascadeGO:0518979.4IGF2, INS
10positive regulation of cell divisionGO:0517819.3VEGFA, IGF2
11platelet degranulationGO:0025769.2IGF2, VEGFA
12positive regulation of cell growthGO:0303079.0F2, INS
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0INS, IGF2, VEGFA
14positive regulation of protein phosphorylationGO:0019348.9F2, IGF2, VEGFA
15cellular protein metabolic processGO:0442678.9F2, INS, IGF2
16platelet activationGO:0301688.8VEGFA, IGF2, F2
17blood coagulationGO:0075968.7F2, IGF2, VEGFA
18positive regulation of cell proliferationGO:0082848.4VEGFA, IGF2, INS, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5INS, IGF2
2insulin-like growth factor receptor bindingGO:0051599.4INS, IGF2
3insulin receptor bindingGO:0051589.2INS, IGF2
4growth factor activityGO:0080838.6F2, IGF2, VEGFA

Products for genes affiliated with Hypoglycemic Coma

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Sources for Hypoglycemic Coma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet