MCID: HYP026
MIFTS: 45

Hypoglycemic Coma malady

Summaries for Hypoglycemic Coma

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MalaCards: Hypoglycemic Coma, also known as hypoglycemic coma nos, is related to hepatitis and hypoglycemia. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Asparagine N-linked glycosylation and SHC-mediated signalling. The compounds aprotinin and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and heart, and related mouse phenotypes are skeleton and cardiovascular system.

Aliases & Classifications for Hypoglycemic Coma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

hypoglycemic coma 8 10 44 60
hypoglycemic coma nos 8
hypoglycaemic coma 8


External Ids:

Disease Ontology8 DOID:1607
ICD9CM27 251.0

Related Diseases for Hypoglycemic Coma

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17GeneCards, 18GeneDecks
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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4F2
2hypoglycemia30.4INS, IGF2
3ischemia30.1VEGFA
4hepatitis b30.1F2
5peritonitis30.1F2
6diabetes mellitus30.1INS, VEGFA
7cerebritis10.5
8anorexia nervosa10.4
9hepatitis a10.3
10hepatic coma10.3
11mucinous cystadenocarcinoma10.2
12appendix mucinous cystadenocarcinoma10.2
13sheehan syndrome10.2
14cystadenocarcinoma10.2
15glycogen storage disease10.2
16normal pressure hydrocephalus10.1
17diabetic ketoacidosis10.1
18benign pleural mesothelioma10.1
19neuronitis10.1
20central pontine myelinolysis10.1
21silent myocardial infarction10.1
22insulinoma10.1
23benign mesothelioma10.1
24hepatocellular carcinoma10.1
25hydrocephalus10.1
26myocardial infarction10.1
27schizophrenia10.1
28type 2 diabetes mellitus10.1
29medium-chain acyl-coenzyme a dehydrogenase deficiency10.1
30laron syndrome10.0IGF2
31hepatoblastoma10.0IGF2
32peripheral vascular disease10.0INS
33ovarian hyperstimulation syndrome10.0VEGFA
34coronary heart disease10.0INS
35proliferative diabetic retinopathy10.0VEGFA
36infertility10.0INS
37osteosclerosis10.0IGF2
38cystic fibrosis10.0INS
39hemangioma10.0VEGFA
40morbid obesity10.0INS
41central retinal vein occlusion10.0VEGFA
42wilms tumor10.0IGF2
43hypercholesterolemia10.0INS
44adrenal adenoma10.0IGF2
45choriocarcinoma10.0IGF2
46diabetic macular edema10.0VEGFA
47diarrhea10.0INS
48neonatal diabetes mellitus10.0INS
49myeloma10.0VEGFA
50hemangiopericytoma10.0IGF2

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Clinical Features for Hypoglycemic Coma

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Drugs & Therapeutics for Hypoglycemic Coma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypoglycemic Coma

Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Search CenterWatch for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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32MalaCards
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MalaCards organs/tissues related to Hypoglycemic Coma:

32
Brain, Liver, Heart, Breast, Endothelial, Temporal lobe

Animal Models for Hypoglycemic Coma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypoglycemic Coma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7VEGFA
2MP:00053858.9F2, INS, IGF2
3MP:00053818.2F2, INS, IGF2, VEGFA
4MP:00107718.1VEGFA, IGF2, INS, F2
5MP:00053808.0VEGFA, IGF2, INS, F2
6MP:00053897.8F2, INS, IGF2, VEGFA

Publications for Hypoglycemic Coma

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50PubMed
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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy. (24097322)
2013
2
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. (24150837)
2013
3
Silent myocardial infarction during hypoglycemic coma. (22276266)
2012
4
Decreased vascular endothelial growth factor response to acute hypoglycemia in type 2 diabetic patients with hypoglycemic coma. (22209065)
2012
5
Bilateral posterior shoulder dislocation with defect secondary to hypoglycemic coma. (21246228)
2011
6
Hypoglycemic coma in a patient with anorexia nervosa coincident with acute exacerbation of liver injury induced by oral intake of nutrients. (20686290)
2010
7
The influence of hypoglycemia on cerebral blood flow in cases of hypoglycemic coma. (19305083)
2009
8
Truncation of the krebs cycle during hypoglycemic coma. (18673151)
2008
9
Teaching NeuroImage: hippocampal involvement in a patient with hypoglycemic coma. (19001244)
2008
10
Extensive white matter injury in hypoglycemic coma. (17389314)
2007
11
The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma. (17317199)
2007
12
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. (17319862)
2007
13
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
14
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
15
Malignant solitary fibrous tumor of the thigh accompanied by hypoglycemic coma. A case report. (16080476)
2005
16
Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin? (15678315)
2005
17
Reversible hyperintensity lesion on diffusion-weighted MRI in hypoglycemic coma. (15277649)
2004
18
Hypoglycemic coma in a pregnant woman in association with hepatitis B virus carrier state and hepatocellular carcinoma. (14745290)
2004
19
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. (12971357)
2003
20
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. (12974447)
2003
21
Protein ubiquitination in rat brain following hypoglycemic coma. (11165431)
2001
22
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets. (11412899)
2001
23
Diffusion-weighted MR in hypoglycemic coma. (11552039)
2001
24
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. (11083229)
2000
25
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. (10670909)
2000
26
Is neuronal injury caused by hypoglycemic coma of the necrotic or apoptotic type? (10905628)
2000
27
Glibenclamide-induced hypoglycemic coma in 51 older patients with type 2 diabetes mellitus. (10323665)
1999
28
Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. (9836523)
1998
29
Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)
1996
30
Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. (7750077)
1995
31
Brain calcium metabolism in hypoglycemic coma. (8408320)
1993
32
Recovery of mitochondrial and plasma membrane function following hypoglycemic coma: coupling of ATP synthesis, K+ transport, and changes in extra- and intracellular pH. (8360288)
1993
33
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. (1731336)
1992
34
Increasing incidence of hypoglycemic coma in children with IDDM. (1797479)
1991
35
Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. (2183736)
1990
36
Extracellular pH in the rat brain during hypoglycemic coma and recovery. (2303542)
1990
37
Insulinoma complicating pregnancy presenting with hypoglycemic coma after delivery: a case report and review of the literature. (2539573)
1989
38
gamma-Aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis. (4088534)
1985
39
Hypoglycemic coma induced by inadvertent administration of glyburide. (6421558)
1984
40
Hypoglycemic coma due to disopyramide toxicity. (6635745)
1983
41
Hypoglycemic coma associated with CSII. (6872815)
1983
42
Hypoglycemic coma: don't overlook acute adrenal crisis. (6279471)
1982
43
Insulin-induced hypoglycemic coma and regional cerebral energy metabolism. (7020876)
1981
44
Hypoglycemic coma associated with benign pleural mesothelioma. (1113546)
1975
45
Jaundice in pregnancy (a case report of infective hepatitis in pregnancy with hypofibrinogenenia and hypoglycemic coma). (4457638)
1974
46
Cerebral metabolism in schizophrenia. Study on L-(U- 14 C) glutamine and L-(U- 14 C) glutamic acid under basal conditions and in hypoglycemic coma. (5022651)
1972
47
Cerebrospinal fluid pleocytosis in hypoglycemic coma. (5658451)
1968
48
Alcohol and hypoglycemic coma. (5695588)
1968
49
Hypoglycemic coma following BZ 55; report of a case. (13640693)
1959
50
Hypoglycemic coma and convulsions in fasting bady lambs. (13219928)
1955

Genetic Variations for Hypoglycemic Coma

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Expression for genes affiliated with Hypoglycemic Coma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoglycemic Coma

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Pathways for genes affiliated with Hypoglycemic Coma

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Hypoglycemic Coma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1aprotinin44 1111.0IGF2
2heparin44 28 11 2412.9VEGFA
3dehydroepiandrosterone sulfate449.8INS, IGF2
4nicotinamide44 1110.8IGF2, INS
5levonorgestrel44 59 28 1112.7F2, IGF2
62-deoxyglucose44 1110.7INS, IGF2
7desogestrel44 1110.7F2, INS
8c-peptide449.7IGF2, INS
9cyproteroneacetate449.7INS, F2
10dhea449.7INS, IGF2
11protamine449.6F2, INS
12androstenedione44 2410.6IGF2, INS
13leucovorin44 49 1111.5IGF2, VEGFA
14gliclazide44 49 1111.5INS, VEGFA
15carnitine449.5INS, IGF2
16irinotecan44 49 1111.3IGF2, VEGFA
17silymarin449.3VEGFA, F2
18gefitinib44 49 1111.3IGF2, VEGFA
19lactate449.2F2, INS, IGF2
20creatinine449.1F2, INS, IGF2
21polyethylene glycol449.1F2, IGF2
22progestin449.1IGF2, VEGFA
23octreotide44 59 28 1112.1INS, IGF2, VEGFA
24pioglitazone44 49 28 1112.1INS, IGF2, VEGFA
25rapamycin449.0VEGFA, IGF2, INS
26ly294002449.0INS, IGF2, VEGFA
27suramin44 28 1111.0VEGFA, IGF2, F2
28tamoxifen44 49 28 1111.9F2, IGF2, VEGFA
29estrogen448.4VEGFA, IGF2, INS, F2

GO Terms for genes affiliated with Hypoglycemic Coma

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16Gene Ontology
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Cellular components related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3F2, INS
2platelet alpha granule lumenGO:0310939.1IGF2, VEGFA
3extracellular spaceGO:0056158.1F2, INS, IGF2, VEGFA
4extracellular regionGO:0055767.8VEGFA, IGF2, INS, F2

Biological processes related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:0466289.8IGF2, INS
2positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF2
3positive regulation of mitosisGO:0458409.7IGF2, INS
4negative regulation of proteolysisGO:0458619.6F2, INS
5positive regulation of MAPK cascadeGO:0434109.6IGF2, INS
6acute-phase responseGO:0069539.5F2, INS
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5F2, INS
8positive regulation of protein autophosphorylationGO:0319549.4INS, VEGFA
9positive regulation of protein kinase B signaling cascadeGO:0518979.4IGF2, INS
10positive regulation of cell divisionGO:0517819.3VEGFA, IGF2
11platelet degranulationGO:0025769.2IGF2, VEGFA
12positive regulation of cell growthGO:0303079.0F2, INS
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0INS, IGF2, VEGFA
14positive regulation of protein phosphorylationGO:0019348.9F2, IGF2, VEGFA
15cellular protein metabolic processGO:0442678.9F2, INS, IGF2
16platelet activationGO:0301688.8VEGFA, IGF2, F2
17blood coagulationGO:0075968.7F2, IGF2, VEGFA
18positive regulation of cell proliferationGO:0082848.4VEGFA, IGF2, INS, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5INS, IGF2
2insulin-like growth factor receptor bindingGO:0051599.4INS, IGF2
3insulin receptor bindingGO:0051589.2INS, IGF2
4growth factor activityGO:0080838.6F2, IGF2, VEGFA

Products for genes affiliated with Hypoglycemic Coma

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Sources for Hypoglycemic Coma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet