MCID: HYP026
MIFTS: 45

Hypoglycemic Coma malady

Summaries for Hypoglycemic Coma

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MalaCards: Hypoglycemic Coma, also known as hypoglycemic coma nos, is related to hepatitis and hypoglycemia. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Asparagine N-linked glycosylation and SHC-mediated signalling. The compounds aprotinin and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and heart, and related mouse phenotypes are skeleton and cardiovascular system.

Aliases & Classifications for Hypoglycemic Coma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

hypoglycemic coma 8 10 44 60
hypoglycemic coma nos 8
hypoglycaemic coma 8


External Ids:

Disease Ontology8 DOID:1607
ICD9CM27 251.0

Related Diseases for Hypoglycemic Coma

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17GeneCards, 18GeneDecks
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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4F2
2hypoglycemia30.4INS, IGF2
3ischemia30.1VEGFA
4hepatitis b30.1F2
5peritonitis30.1F2
6diabetes mellitus30.1INS, VEGFA
7cerebritis10.5
8anorexia nervosa10.4
9hepatitis a10.3
10hepatic coma10.3
11mucinous cystadenocarcinoma10.2
12appendix mucinous cystadenocarcinoma10.2
13sheehan syndrome10.2
14cystadenocarcinoma10.2
15glycogen storage disease10.2
16normal pressure hydrocephalus10.1
17diabetic ketoacidosis10.1
18benign pleural mesothelioma10.1
19neuronitis10.1
20central pontine myelinolysis10.1
21silent myocardial infarction10.1
22insulinoma10.1
23benign mesothelioma10.1
24hepatocellular carcinoma10.1
25hydrocephalus10.1
26myocardial infarction10.1
27schizophrenia10.1
28type 2 diabetes mellitus10.1
29medium-chain acyl-coenzyme a dehydrogenase deficiency10.1
30laron syndrome10.0IGF2
31hepatoblastoma10.0IGF2
32peripheral vascular disease10.0INS
33ovarian hyperstimulation syndrome10.0VEGFA
34coronary heart disease10.0INS
35proliferative diabetic retinopathy10.0VEGFA
36infertility10.0INS
37osteosclerosis10.0IGF2
38cystic fibrosis10.0INS
39hemangioma10.0VEGFA
40morbid obesity10.0INS
41central retinal vein occlusion10.0VEGFA
42wilms tumor10.0IGF2
43hypercholesterolemia10.0INS
44adrenal adenoma10.0IGF2
45choriocarcinoma10.0IGF2
46diabetic macular edema10.0VEGFA
47diarrhea10.0INS
48neonatal diabetes mellitus10.0INS
49myeloma10.0VEGFA
50hemangiopericytoma10.0IGF2

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Clinical Features for Hypoglycemic Coma

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Drugs & Therapeutics for Hypoglycemic Coma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypoglycemic Coma

Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Search CenterWatch for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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32MalaCards
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MalaCards organs/tissues related to Hypoglycemic Coma:

32
Brain, Liver, Heart, Breast, Endothelial, Temporal lobe

Animal Models for Hypoglycemic Coma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypoglycemic Coma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7VEGFA
2MP:00053858.9F2, INS, IGF2
3MP:00053818.2F2, INS, IGF2, VEGFA
4MP:00107718.1VEGFA, IGF2, INS, F2
5MP:00053808.0VEGFA, IGF2, INS, F2
6MP:00053897.8F2, INS, IGF2, VEGFA

Publications for Hypoglycemic Coma

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50PubMed
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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. (24150837)
2013
2
Decreased vascular endothelial growth factor response to acute hypoglycemia in type 2 diabetic patients with hypoglycemic coma. (22209065)
2012
3
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. (21056562)
2011
4
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. (21400210)
2011
5
Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. (21439874)
2011
6
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. (20887629)
2010
7
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. (18202087)
2008
8
Teaching NeuroImage: hippocampal involvement in a patient with hypoglycemic coma. (19001244)
2008
9
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. (17319862)
2007
10
Bilateral basal ganglia lesions after hypoglycemic coma in a 6-year-old child. (17621490)
2007
11
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
12
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa. (16168799)
2005
13
Magnetic resonance imaging and diffusion-weighted imaging changes after hypoglycemic coma. (15746233)
2005
14
Hypoglycemic coma in a diabetic patient on peritoneal dialysis due to interference of icodextrin metabolites with capillary blood glucose measurements. (15333503)
2004
15
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. (12974447)
2003
16
Diffusion-weighted MR in hypoglycemic coma. (11552039)
2001
17
Adrenal crisis presenting as hypoglycemic coma. (10663290)
2000
18
Response to training in blood glucose awareness is related to absence of previous hypoglycemic coma. (10937524)
2000
19
Glibenclamide-induced hypoglycemic coma in 51 older patients with type 2 diabetes mellitus. (10323665)
1999
20
Hypoketotic hypoglycemic coma in a 21-month-old child. (10459098)
1999
21
Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive. (10362687)
1999
22
Drug-induced hypoglycemic coma in 102 diabetic patients. (9989540)
1999
23
Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. (9836523)
1998
24
Hypoglycemic coma associated with brain infarcts. (17895073)
1998
25
Influence of hypoglycemic coma on brain water and osmolality. (9655231)
1998
26
Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)
1996
27
Brain calcium metabolism in hypoglycemic coma. (8408320)
1993
28
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. (1731336)
1992
29
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
30
Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. (2183736)
1990
31
Hypoglycemic coma from pentamadine in an AIDS patient. (3487333)
1986
32
Fetal heart rate in maternal hypoglycemic coma. (2860035)
1985
33
Frequency of diabetic ketoacidosis and hypoglycemic coma during treatment with continuous subcutaneous insulin infusion. Audit of medical care. (3934967)
1985
34
Hypoglycemic coma in a high school dropout. (2989302)
1985
35
Hypoglycemic coma induced by inadvertent administration of glyburide. (6421558)
1984
36
Neurophysiological recovery after hypoglycemic coma in the rat: correlation with cerebral metabolism. (6822622)
1983
37
Ethanol-induced hypoglycemic coma in a child. (7073036)
1982
38
Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy. (7396601)
1980
39
Isolated corticotrophin-deficiency found through alcohol-induced hypoglycemic coma. (182631)
1976
40
Changes of human somatosensory evoked response in the course of insulin hypoglycemic coma. (5394541)
1969
41
Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases. (6046558)
1967
42
Hypoglycemic coma in a diabetic patient treated with tolbutamide. (5907293)
1966
43
HYPOGLYCEMIC COMA DURING SULFONYLUREA THERAPY. (14281786)
1965
44
CHLORPROPAMIDE-INDUCED HYPOGLYCEMIC COMA. (14195808)
1964
45
Analeptic action of peripheral electrical stimulation in hypoglycemic coma. (14407673)
1959
46
Spontaneous hypoglycemic coma in childhood. (13644564)
1959
47
An investigation of the role played by oxygen and by cellular respiration in hypoglycemic coma. (13323105)
1956
48
Delayed pathologic manifestations of hypoglycemic coma. (14939050)
1952
49
Irreversible post-hypoglycemic coma. (14885206)
1951
50
Studies on baby pig mortality. VII. The effectiveness of certain sugars other than glucose in alleviating hypoglycemic coma in fasting newborn pigs. (14887338)
1951

Genetic Variations for Hypoglycemic Coma

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Expression for genes affiliated with Hypoglycemic Coma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoglycemic Coma

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Pathways for genes affiliated with Hypoglycemic Coma

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Hypoglycemic Coma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1aprotinin44 1111.0IGF2
2heparin44 28 11 2412.9VEGFA
3dehydroepiandrosterone sulfate449.8INS, IGF2
4nicotinamide44 1110.8IGF2, INS
5levonorgestrel44 59 28 1112.7F2, IGF2
62-deoxyglucose44 1110.7INS, IGF2
7desogestrel44 1110.7F2, INS
8c-peptide449.7IGF2, INS
9cyproteroneacetate449.7INS, F2
10dhea449.7INS, IGF2
11protamine449.6F2, INS
12androstenedione44 2410.6IGF2, INS
13leucovorin44 49 1111.5IGF2, VEGFA
14gliclazide44 49 1111.5INS, VEGFA
15carnitine449.5INS, IGF2
16irinotecan44 49 1111.3IGF2, VEGFA
17silymarin449.3VEGFA, F2
18gefitinib44 49 1111.3IGF2, VEGFA
19lactate449.2F2, INS, IGF2
20creatinine449.1F2, INS, IGF2
21polyethylene glycol449.1F2, IGF2
22progestin449.1IGF2, VEGFA
23octreotide44 59 28 1112.1INS, IGF2, VEGFA
24pioglitazone44 49 28 1112.1INS, IGF2, VEGFA
25rapamycin449.0VEGFA, IGF2, INS
26ly294002449.0INS, IGF2, VEGFA
27suramin44 28 1111.0VEGFA, IGF2, F2
28tamoxifen44 49 28 1111.9F2, IGF2, VEGFA
29estrogen448.4VEGFA, IGF2, INS, F2

GO Terms for genes affiliated with Hypoglycemic Coma

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16Gene Ontology
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Cellular components related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3F2, INS
2platelet alpha granule lumenGO:0310939.1IGF2, VEGFA
3extracellular spaceGO:0056158.1F2, INS, IGF2, VEGFA
4extracellular regionGO:0055767.8VEGFA, IGF2, INS, F2

Biological processes related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:0466289.8IGF2, INS
2positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF2
3positive regulation of mitosisGO:0458409.7IGF2, INS
4negative regulation of proteolysisGO:0458619.6F2, INS
5positive regulation of MAPK cascadeGO:0434109.6IGF2, INS
6acute-phase responseGO:0069539.5F2, INS
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5F2, INS
8positive regulation of protein autophosphorylationGO:0319549.4INS, VEGFA
9positive regulation of protein kinase B signaling cascadeGO:0518979.4IGF2, INS
10positive regulation of cell divisionGO:0517819.3VEGFA, IGF2
11platelet degranulationGO:0025769.2IGF2, VEGFA
12positive regulation of cell growthGO:0303079.0F2, INS
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0INS, IGF2, VEGFA
14positive regulation of protein phosphorylationGO:0019348.9F2, IGF2, VEGFA
15cellular protein metabolic processGO:0442678.9F2, INS, IGF2
16platelet activationGO:0301688.8VEGFA, IGF2, F2
17blood coagulationGO:0075968.7F2, IGF2, VEGFA
18positive regulation of cell proliferationGO:0082848.4VEGFA, IGF2, INS, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5INS, IGF2
2insulin-like growth factor receptor bindingGO:0051599.4INS, IGF2
3insulin receptor bindingGO:0051589.2INS, IGF2
4growth factor activityGO:0080838.6F2, IGF2, VEGFA

Products for genes affiliated with Hypoglycemic Coma

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Sources for Hypoglycemic Coma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet