MCID: HYP026
MIFTS: 50

Hypoglycemic Coma malady

Endocrine diseases, Neuronal diseases categories
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Summaries for Hypoglycemic Coma

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MalaCards based summary: Hypoglycemic Coma, also known as hypoglycaemic coma, is related to hypoglycemia and insulinoma. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Insulin receptor signalling cascade and Cardiac Progenitor Differentiation. The compounds dehydroepiandrosterone sulfate and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Hypoglycemic Coma

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Hypoglycemic Coma, Aliases & Descriptions:

Name: Hypoglycemic Coma 8 10 44 62
Hypoglycaemic Coma 8 62
 
Hypoglycemic Coma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:1607
ICD9CM27 251.0

Related Diseases for Hypoglycemic Coma

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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.7IGF2, INS
2insulinoma30.5IGF2, INS
3cerebritis10.6
4laron syndrome10.4IGF2
5anorexia nervosa10.4
6insulin autoimmune syndrome10.4
7solitary fibrous tumor10.4
8central retinal vein occlusion10.4VEGFA
9diabetic macular edema10.4VEGFA
10meningioma10.3IGF2
11hepatitis10.3
12hepatocellular carcinoma10.3
13hyperinsulinemic hypoglycemia10.2INS, IGF2
14fetal macrosomia10.2INS, IGF2
15glycogen storage disease10.2
16sheehan syndrome10.2
17mucinous cystadenocarcinoma10.2
18cystadenocarcinoma10.2
19growth hormone deficiency10.2INS, IGF2
20hyperandrogenism10.2INS, IGF2
21acromegaly10.2IGF2, INS
22cerebral hemorrhage10.2
23diabetes mellitus10.2
24hepatitis b10.2
25hydrocephalus10.2
26myocardial infarction10.2
27schizophrenia10.2
28type 2 diabetes mellitus10.2
29diabetic ketoacidosis10.2
30normal pressure hydrocephalus10.2
31central pontine myelinolysis10.2
32silent myocardial infarction10.2
33benign pleural mesothelioma10.2
34neuronitis10.2
35ischemia10.2
36peritonitis10.2
37medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
38isolated acth deficiency10.2
39acth deficiency10.2
40phyllode tumor10.2
41endotheliitis10.2
42polycystic ovary syndrome10.2INS, IGF2
43short stature10.2IGF2, INS
44diabetic retinopathy10.1VEGFA, INS
45blindness10.1INS, VEGFA
46hyperinsulinism10.1IGF2, INS
47type 1 diabetes mellitus10.1INS, IGF2
48proteinuria10.1VEGFA, INS
49chronic kidney failure10.0IGF2, INS
50cork-handlers' disease10.0F2, INS

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Symptoms for Hypoglycemic Coma

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Drugs & Therapeutics for Hypoglycemic Coma

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Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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MalaCards organs/tissues related to Hypoglycemic Coma:

32
Brain, Heart, Liver, Breast, Endothelial, Temporal lobe

Animal Models for Hypoglycemic Coma or affiliated genes

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MGI Mouse Phenotypes related to Hypoglycemic Coma:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8VEGFA, INS, IGF2
2MP:00053678.7VEGFA, INS, IGF2
3MP:00030128.6IGF2, INS, VEGFA
4MP:00053818.4VEGFA, INS, IGF2, F2
5MP:00053908.3F2, IGF2, INS, VEGFA
6MP:00107718.3VEGFA, INS, IGF2, F2
7MP:00053808.3F2, IGF2, INS, VEGFA
8MP:00053898.3VEGFA, INS, IGF2, F2
9MP:00053858.3F2, IGF2, INS, VEGFA
10MP:00053978.3VEGFA, INS, IGF2, F2
11MP:00053888.3VEGFA, IGF2, F2
12MP:00053878.3F2, IGF2, INS, VEGFA
13MP:00053848.2VEGFA, INS, IGF2, F2
14MP:00036318.2F2, IGF2, INS, VEGFA
15MP:00053788.1F2, IGF2, INS, VEGFA
16MP:00053768.1VEGFA, INS, IGF2, F2

Publications for Hypoglycemic Coma

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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. (25289063)
2014
2
Recurrent Hypoglycemic Coma as the Initial and Single Clinical Manifestation of Advanced Hepatocellular Carcinoma. (25407746)
2014
3
Silent myocardial infarction during hypoglycemic coma. (22276266)
2012
4
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. (21056562)
2011
5
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. (21400210)
2011
6
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. (20887629)
2010
7
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. (18202087)
2008
8
Truncation of the krebs cycle during hypoglycemic coma. (18673151)
2008
9
Extensive white matter injury in hypoglycemic coma. (17389314)
2007
10
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
11
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
12
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa. (16168799)
2005
13
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. (15098777)
2004
14
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. (12971357)
2003
15
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. (12974447)
2003
16
Protein ubiquitination in rat brain following hypoglycemic coma. (11165431)
2001
17
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. (11083229)
2000
18
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. (10973608)
2000
19
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. (10670909)
2000
20
Hypoglycemic coma masquerading thyrotoxic storm. (10563748)
1999
21
Glibenclamide-induced hypoglycemic coma in 51 older patients with type 2 diabetes mellitus. (10323665)
1999
22
Hypoketotic hypoglycemic coma in a 21-month-old child. (10459098)
1999
23
Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive. (10362687)
1999
24
Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)
1996
25
Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. (7750077)
1995
26
Brain calcium metabolism in hypoglycemic coma. (8408320)
1993
27
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. (1731336)
1992
28
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
29
Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. (2183736)
1990
30
Extracellular pH in the rat brain during hypoglycemic coma and recovery. (2303542)
1990
31
Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. (2719056)
1989
32
Fetal heart rate in maternal hypoglycemic coma. (2860035)
1985
33
Hypoglycemic coma induced by inadvertent administration of glyburide. (6421558)
1984
34
Ethanol-induced hypoglycemic coma in a child. (7073036)
1982
35
Hypoglycemic coma due to use of an improper battery in a commonly used insulin pump. (6927734)
1982
36
Hypoglycemic coma: don't overlook acute adrenal crisis. (6279471)
1982
37
Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy. (7396601)
1980
38
Hypoglycemic coma associated with benign pleural mesothelioma. (1113546)
1975
39
Jaundice in pregnancy (a case report of infective hepatitis in pregnancy with hypofibrinogenenia and hypoglycemic coma). (4457638)
1974
40
Cerebral metabolism in schizophrenia. Study on L-(U- 14 C) glutamine and L-(U- 14 C) glutamic acid under basal conditions and in hypoglycemic coma. (5022651)
1972
41
Changes of human somatosensory evoked response in the course of insulin hypoglycemic coma. (5394541)
1969
42
Cerebrospinal fluid pleocytosis in hypoglycemic coma. (5658451)
1968
43
Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases. (6046558)
1967
44
Hypoglycemic coma in a diabetic patient treated with tolbutamide. (5907293)
1966
45
HYPOGLYCEMIC COMA DURING SULFONYLUREA THERAPY. (14281786)
1965
46
CHLORPROPAMIDE-INDUCED HYPOGLYCEMIC COMA. (14195808)
1964
47
Analeptic action of peripheral electrical stimulation in hypoglycemic coma. (14407673)
1959
48
Hypoglycemic coma following BZ 55; report of a case. (13640693)
1959
49
Hypoglycemic coma and convulsions in fasting bady lambs. (13219928)
1955
50
Irreversible post-hypoglycemic coma. (14885206)
1951

Variations for Hypoglycemic Coma

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Expression for genes affiliated with Hypoglycemic Coma

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Expression patterns in normal tissues for genes affiliated with Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for genes affiliated with Hypoglycemic Coma

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Pathways related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5INS, IGF2
29.5INS, IGF2
39.4IGF2, F2
4
Show member pathways
thioredoxin pathway37
9.3F2, INS
59.3INS, F2
6
Show member pathways
9.2VEGFA, IGF2
79.2IGF2, VEGFA
89.1INS, VEGFA
99.1VEGFA, INS
10
Show member pathways
Signaling Pathways in Glioblastoma37
9.1VEGFA, INS
11
Show member pathways
8.9INS, IGF2, F2
12
Show member pathways
8.9INS, IGF2, F2
13
Show member pathways
8.9INS, IGF2, F2
14
Show member pathways
8.6F2, IGF2, VEGFA
15
Show member pathways
8.5F2, INS, VEGFA
16
Show member pathways
8.1VEGFA, INS, IGF2, F2

Compounds for genes affiliated with Hypoglycemic Coma

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Compounds related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dehydroepiandrosterone sulfate449.9INS, IGF2
2nicotinamide44 1110.8INS, IGF2
32-deoxyglucose44 1110.8INS, IGF2
4c-peptide449.8IGF2, INS
5dhea449.8INS, IGF2
6androstenedione44 2410.8IGF2, INS
7levonorgestrel44 61 28 1112.8IGF2, F2
8desogestrel44 1110.8INS, F2
9carnitine449.7IGF2, INS
10cyproteroneacetate449.7F2, INS
11protamine449.7INS, F2
12hydrocortisone44 2 61 1112.7IGF2, INS
13aprotinin44 1110.7IGF2, F2
14ibmx44 61 2811.7INS, IGF2
15polyethylene glycol449.7F2, IGF2
16thyroxine44 2410.6IGF2, INS
17leucovorin44 50 1111.6IGF2, VEGFA
18gliclazide44 50 1111.5VEGFA, INS
19gefitinib44 50 1111.5VEGFA, IGF2
20irinotecan44 50 1111.5VEGFA, IGF2
21progestin449.5VEGFA, IGF2
22silymarin449.4VEGFA, F2
23calcitriol44 61 24 1112.4IGF2, F2
24lactate449.3F2, IGF2, INS
25creatinine449.3F2, IGF2, INS
26acth449.2INS, IGF2
27imatinib44 50 1111.2VEGFA, IGF2
28simvastatin44 50 61 28 24 1114.2VEGFA, F2
29octreotide44 61 28 1112.1VEGFA, INS, IGF2
30pioglitazone28 44 50 1112.1VEGFA, INS, IGF2
31prostacyclin449.1IGF2, VEGFA
32hyaluronic acid44 2410.1VEGFA, F2
33alanine449.1INS, IGF2, F2
34rapamycin449.1VEGFA, INS, IGF2
35ly294002449.1VEGFA, INS, IGF2
36suramin44 28 1111.0F2, IGF2, VEGFA
37tamoxifen44 50 28 1112.0F2, IGF2, VEGFA
38dexamethasone44 50 28 1112.0IGF2, INS, VEGFA
39heparin44 28 24 1111.9VEGFA, IGF2, F2
40estrogen448.5F2, IGF2, INS, VEGFA

GO Terms for genes affiliated with Hypoglycemic Coma

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Cellular components related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.3INS, F2
2platelet alpha granule lumenGO:0310939.1VEGFA, IGF2
3Golgi lumenGO:0057969.0INS, F2
4extracellular spaceGO:0056158.1VEGFA, INS, IGF2, F2
5extracellular regionGO:0055768.1F2, IGF2, INS, VEGFA

Biological processes related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:0466289.8INS, IGF2
2positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF2
3positive regulation of mitosisGO:0458409.8INS, IGF2
4positive regulation of MAPK cascadeGO:0434109.7INS, IGF2
5negative regulation of proteolysisGO:0458619.6F2, INS
6positive regulation of protein kinase B signalingGO:0518979.6IGF2, INS
7acute-phase responseGO:0069539.6INS, F2
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6INS, F2
9insulin receptor signaling pathwayGO:0082869.5INS, IGF2
10positive regulation of cell growthGO:0303079.5INS, F2
11positive regulation of protein autophosphorylationGO:0319549.5INS, VEGFA
12positive regulation of cell divisionGO:0517819.4VEGFA, IGF2
13glucose metabolic processGO:0060069.4IGF2, INS
14platelet degranulationGO:0025769.3VEGFA, IGF2
15cellular protein metabolic processGO:0442679.1F2, IGF2, INS
16regulation of cell shapeGO:0083609.0VEGFA, F2
17positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0IGF2, INS, VEGFA
18positive regulation of protein phosphorylationGO:0019348.9VEGFA, IGF2, F2
19platelet activationGO:0301688.9VEGFA, IGF2, F2
20positive regulation of cell migrationGO:0303358.8VEGFA, INS
21blood coagulationGO:0075968.8F2, IGF2, VEGFA
22positive regulation of cell proliferationGO:0082848.4VEGFA, INS, IGF2, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.5INS, IGF2
2insulin receptor bindingGO:0051589.4INS, IGF2
3hormone activityGO:0051799.2IGF2, INS
4growth factor activityGO:0080838.6VEGFA, IGF2, F2
5protein bindingGO:0055157.5VEGFA, INS, IGF2, F2, GBP3

Products for genes affiliated with Hypoglycemic Coma

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Sources for Hypoglycemic Coma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet