MCID: HYP026
MIFTS: 37

Hypoglycemic Coma

Categories: Endocrine diseases, Neuronal diseases

Aliases & Classifications for Hypoglycemic Coma

MalaCards integrated aliases for Hypoglycemic Coma:

Name: Hypoglycemic Coma 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1607
ICD10 33 E15
ICD9CM 35 251.0
UMLS 69 C0020617

Summaries for Hypoglycemic Coma

MalaCards based summary : Hypoglycemic Coma is related to acyl-coa dehydrogenase, medium chain, deficiency of and metal metabolism disorder. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are HIF-1 signaling pathway and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Daclizumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and temporal lobe, and related phenotypes are mortality/aging and muscle

Related Diseases for Hypoglycemic Coma

Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 acyl-coa dehydrogenase, medium chain, deficiency of 10.9
2 metal metabolism disorder 10.4 INS VEGFA
3 hyperphosphatasia with mental retardation syndrome 3 10.2 IGF2 INS
4 spondylolysis 10.2 INS VEGFA
5 fetal parvovirus syndrome 10.2 IGF2 INS
6 limb-mammary syndrome 10.2 IGF2 INS
7 kartagener syndrome 10.2 IGF2 INS
8 periampullary adenoma 10.2 INS VEGFA
9 cerebritis 10.2
10 pericardial tuberculosis 10.2 IGF2 INS
11 paroxysmal nonkinesigenic dyskinesia 2 10.1 HBA2 INS
12 citrullinemia, adult-onset type ii 10.1 INS VEGFA
13 neurogenic arthropathy 10.1 IGF2 INS
14 neuropathy, hereditary sensory and autonomic, type ic 10.1 HBA2 INS
15 chondroma 10.1 IGF2 INS
16 tinf2-related dyskeratosis congenita 10.1 HBA2 INS
17 hemopericardium 10.1 HBA2 INS
18 diabetic cataract 10.1 IGF2 INS
19 anorexia nervosa 10.1
20 congenital heart defects, nonsyndromic, 2 10.1 HBA2 INS
21 insulin autoimmune syndrome 10.0
22 gallbladder cancer 10.0 IGF2 VEGFA
23 chronic lacrimal gland enlargement 9.9 NTF3 VEGFA
24 rumination disorder 9.9 INS NTF3
25 hypoglycemia 9.9
26 hepatocellular carcinoma 9.9
27 hepatitis 9.9
28 hypertrichosis 9.9 HBA2 INS
29 thrombophilia 9.9 IGF2 INS
30 survival motor neuron spinal muscular atrophy 9.8 HBA2 INS
31 insulinoma 9.8
32 normal pressure hydrocephalus 9.8
33 ischemia 9.8
34 benign pleural mesothelioma 9.8
35 silent myocardial infarction 9.8
36 central pontine myelinolysis 9.8
37 schizophrenia 9.8
38 neuronitis 9.8
39 myocardial infarction 9.8
40 peritonitis 9.8
41 acth deficiency 9.8
42 cerebral hemorrhage 9.8
43 phyllode tumor 9.8
44 endotheliitis 9.8
45 hepatitis b 9.8
46 hydrocephalus 9.8
47 submucous uterine fibroid 9.7 HBA2 INS VEGFA
48 vernal conjunctivitis 9.7 HBA2 INS VEGFA
49 lung cancer susceptibility 2 9.6 IGF2 INS
50 diffuse large b-cell lymphoma 9.5 INS NTF3 VEGFA

Comorbidity relations with Hypoglycemic Coma via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Hypoglycemia Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Kidney Disease Microvascular Complications of Diabetes 1
Peripheral Vascular Disease Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to Hypoglycemic Coma

Symptoms & Phenotypes for Hypoglycemic Coma

MGI Mouse Phenotypes related to Hypoglycemic Coma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.63 HBA2 IGF2 INS NTF3 SETDB1 VEGFA
2 muscle MP:0005369 9.26 NTF3 VEGFA IGF2 INS
3 reproductive system MP:0005389 9.02 HBA2 IGF2 INS NTF3 VEGFA

Drugs & Therapeutics for Hypoglycemic Coma

Drugs for Hypoglycemic Coma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Daclizumab Approved, Investigational Phase 1, Phase 2 152923-56-3
2
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
3
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
4
Exenatide Approved, Investigational Phase 1, Phase 2 141758-74-9 15991534
5
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
6
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
7 Analgesics Phase 1, Phase 2
8 Analgesics, Non-Narcotic Phase 1, Phase 2
9 Anti-Inflammatory Agents Phase 1, Phase 2
10 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
11 Antirheumatic Agents Phase 1, Phase 2
12 Gastrointestinal Agents Phase 1, Phase 2
13 Hormone Antagonists Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
16 Hypoglycemic Agents Phase 1, Phase 2
17 Immunosuppressive Agents Phase 1, Phase 2
18 Incretins Phase 1, Phase 2
19 Peripheral Nervous System Agents Phase 1, Phase 2
20
Zinc Approved 7440-66-6 32051 23994
21
Pancrelipase Approved 53608-75-6
22
Palmitic Acid Experimental 57-10-3 985
23 insulin
24 Insulin, Globin Zinc
25 pancreatin

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Using Glucose Sensors to Prevent Hypoglycemia Completed NCT00554281 Phase 3
2 Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression Unknown status NCT00566813 Phase 1, Phase 2 Edmonton Protocol of steroid free immunosuppression;Islets of Langerhans Transplantation
3 Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression Active, not recruiting NCT00306098 Phase 2 islets
4 Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose Completed NCT01919788 Insulin (Insuman Rapid);Glucose
5 Exercise Physiology Study Recruiting NCT03090451
6 Sub-Cutaneous Insulin in Hyperglycaemic Emergencies Withdrawn NCT00467246 Levemir

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

Genetic tests related to Hypoglycemic Coma:

id Genetic test Affiliating Genes
1 Hypoglycemic Coma 29

Anatomical Context for Hypoglycemic Coma

MalaCards organs/tissues related to Hypoglycemic Coma:

39
Brain, Liver, Temporal Lobe, Endothelial, Heart, Eye

Publications for Hypoglycemic Coma

Articles related to Hypoglycemic Coma:

(show top 50) (show all 108)
id Title Authors Year
1
Cognitive, neurophysiologic and metabolic sequelae of previous hypoglycemic coma revealed by hyperinsulinemic-hypoglycemic clamp in type 1 diabetic patients. ( 28589447 )
2017
2
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects. ( 28626178 )
2017
3
Roving eye movements in a patient with hypoglycemic coma. ( 25984318 )
2015
4
Smartwatch's Application Algorithm to Prevent Sudden Death and Brain Damage in Hypoglycemic Coma. ( 26659660 )
2015
5
Reversible corona radiata diffusion restriction in hypoglycemic coma. ( 25553230 )
2015
6
Regional Assessment of Severe Hypoglycemic Coma Events in Finland. ( 27200578 )
2014
7
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. ( 25289063 )
2014
8
Recurrent Hypoglycemic Coma as the Initial and Single Clinical Manifestation of Advanced Hepatocellular Carcinoma. ( 25407746 )
2014
9
A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy. ( 24097322 )
2013
10
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. ( 24150837 )
2013
11
Silent myocardial infarction during hypoglycemic coma. ( 22276266 )
2012
12
Decreased vascular endothelial growth factor response to acute hypoglycemia in type 2 diabetic patients with hypoglycemic coma. ( 22209065 )
2012
13
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. ( 21400210 )
2011
14
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. ( 21056562 )
2011
15
Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. ( 21439874 )
2011
16
Bilateral posterior shoulder dislocation with defect secondary to hypoglycemic coma. ( 21246228 )
2011
17
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. ( 20887629 )
2010
18
Hypoglycemic coma in a patient with anorexia nervosa coincident with acute exacerbation of liver injury induced by oral intake of nutrients. ( 20686290 )
2010
19
The influence of hypoglycemia on cerebral blood flow in cases of hypoglycemic coma. ( 19305083 )
2009
20
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. ( 18202087 )
2008
21
Truncation of the krebs cycle during hypoglycemic coma. ( 18673151 )
2008
22
Teaching NeuroImage: hippocampal involvement in a patient with hypoglycemic coma. ( 19001244 )
2008
23
The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma. ( 17317199 )
2007
24
Extensive white matter injury in hypoglycemic coma. ( 17389314 )
2007
25
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. ( 17319862 )
2007
26
Bilateral basal ganglia lesions after hypoglycemic coma in a 6-year-old child. ( 17621490 )
2007
27
Magnetic resonance imaging and diffusion-weighted imaging changes after hypoglycemic coma. ( 15746233 )
2005
28
Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin? ( 15678315 )
2005
29
Malignant solitary fibrous tumor of the thigh accompanied by hypoglycemic coma. A case report. ( 16080476 )
2005
30
[Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. ( 16292188 )
2005
31
Severe hypoglycemic coma due to insulin autoimmune syndrome. ( 15759820 )
2005
32
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa. ( 16168799 )
2005
33
Hypoglycemic coma in a diabetic patient on peritoneal dialysis due to interference of icodextrin metabolites with capillary blood glucose measurements. ( 15333503 )
2004
34
Reversible hyperintensity lesion on diffusion-weighted MRI in hypoglycemic coma. ( 15277649 )
2004
35
Hypoglycemic coma in a pregnant woman in association with hepatitis B virus carrier state and hepatocellular carcinoma. ( 14745290 )
2004
36
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. ( 15098777 )
2004
37
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. ( 12971357 )
2003
38
Reversible hypoglycemic coma despite bilateral absence of the median nerve N20 evoked potential. ( 12771284 )
2003
39
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. ( 12974447 )
2003
40
Bispectral index monitoring during hypoglycemic coma. ( 12088817 )
2002
41
Protein ubiquitination in rat brain following hypoglycemic coma. ( 11165431 )
2001
42
Diffusion-weighted MR in hypoglycemic coma. ( 11552039 )
2001
43
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets. ( 11412899 )
2001
44
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. ( 10670909 )
2000
45
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. ( 10973608 )
2000
46
Adrenal crisis presenting as hypoglycemic coma. ( 10663290 )
2000
47
Is neuronal injury caused by hypoglycemic coma of the necrotic or apoptotic type? ( 10905628 )
2000
48
Response to training in blood glucose awareness is related to absence of previous hypoglycemic coma. ( 10937524 )
2000
49
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. ( 11083229 )
2000
50
Hypoketotic hypoglycemic coma in a 21-month-old child. ( 10459098 )
1999

Variations for Hypoglycemic Coma

Expression for Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for Hypoglycemic Coma

Pathways related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.36 INS VEGFA
2 11.22 NTF3 VEGFA
3 11.07 IGF2 VEGFA
4 10.88 IGF2 INS
5 10.64 INS VEGFA
6
Show member pathways
10.25 INS VEGFA

GO Terms for Hypoglycemic Coma

Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 HBA2 IGF2 INS NTF3 VEGFA
2 platelet alpha granule lumen GO:0031093 8.96 IGF2 VEGFA

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.57 IGF2 INS
2 positive regulation of MAPK cascade GO:0043410 9.56 IGF2 INS
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.55 NTF3 VEGFA
4 insulin receptor signaling pathway GO:0008286 9.54 IGF2 INS
5 positive regulation of cell migration GO:0030335 9.54 INS NTF3 VEGFA
6 glucose metabolic process GO:0006006 9.52 IGF2 INS
7 positive regulation of cell division GO:0051781 9.51 IGF2 VEGFA
8 positive chemotaxis GO:0050918 9.49 NTF3 VEGFA
9 activation of protein kinase B activity GO:0032148 9.48 INS NTF3
10 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF2 INS
11 positive regulation of receptor internalization GO:0002092 9.43 NTF3 VEGFA
12 positive regulation of protein autophosphorylation GO:0031954 9.4 INS VEGFA
13 positive regulation of glycogen biosynthetic process GO:0045725 9.32 IGF2 INS
14 induction of positive chemotaxis GO:0050930 9.26 NTF3 VEGFA
15 positive regulation of cell proliferation GO:0008284 9.26 IGF2 INS NTF3 VEGFA
16 positive regulation of insulin receptor signaling pathway GO:0046628 9.16 IGF2 INS
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 IGF2 INS NTF3 VEGFA

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.32 IGF2 INS
2 insulin receptor binding GO:0005158 9.26 IGF2 INS
3 chemoattractant activity GO:0042056 9.16 NTF3 VEGFA
4 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS
5 growth factor activity GO:0008083 8.8 IGF2 NTF3 VEGFA

Sources for Hypoglycemic Coma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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