MCID: HYP026
MIFTS: 49

Hypoglycemic Coma malady

Endocrine diseases, Neuronal diseases categories

Summaries for Hypoglycemic Coma

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34MalaCards
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MalaCards: Hypoglycemic Coma, also known as hypoglycemic coma nos, is related to hypoglycemia and insulinoma. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Insulin receptor signalling cascade and Cardiac Progenitor Differentiation. The compounds dehydroepiandrosterone sulfate and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and heart, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Hypoglycemic Coma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Neuronal diseases


Aliases & Descriptions:

hypoglycemic coma 9 11 46 63
hypoglycemic coma nos 9
hypoglycaemic coma 9


External Ids:

Disease Ontology9 DOID:1607
ICD9CM28 251.0

Related Diseases for Hypoglycemic Coma

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18GeneCards, 19GeneDecks
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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.5IGF2, INS
2insulinoma30.3INS, IGF2
3hepatocellular carcinoma30.1F2, IGF2, INS, VEGFA
4cerebritis10.5
5anorexia nervosa10.5
6solitary fibrous tumor10.4
7hepatitis10.3
8insulin autoimmune syndrome10.3
9sheehan syndrome10.2
10mucinous cystadenocarcinoma10.2
11cystadenocarcinoma10.2
12glycogen storage disease10.2
13diabetic ketoacidosis10.2
14normal pressure hydrocephalus10.2
15benign pleural mesothelioma10.2
16neuronitis10.2
17central pontine myelinolysis10.2
18hepatitis b10.2
19silent myocardial infarction10.2
20diabetes mellitus10.2
21hydrocephalus10.2
22ischemia10.2
23myocardial infarction10.2
24peritonitis10.2
25schizophrenia10.2
26type 2 diabetes mellitus10.2
27medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
28isolated acth deficiency10.2
29acth deficiency10.2
30phyllode tumor10.2
31endotheliitis10.2
32laron syndrome10.1IGF2
33central retinal vein occlusion10.1VEGFA
34diabetic macular edema10.1VEGFA
35meningioma10.1IGF2
36hyperinsulinemic hypoglycemia10.0INS, IGF2
37fetal macrosomia10.0INS, IGF2
38growth hormone deficiency10.0IGF2, INS
39hyperandrogenism10.0IGF2, INS
40acromegaly10.0INS, IGF2
41polycystic ovary syndrome10.0INS, IGF2
42short stature10.0INS, IGF2
43diabetic retinopathy10.0VEGFA, INS
44blindness10.0VEGFA, INS
45hyperinsulinism10.0INS, IGF2
46type 1 diabetes mellitus10.0INS, IGF2
47proteinuria10.0VEGFA, INS
48chronic kidney failure10.0INS, IGF2
49cork-handlers' disease10.0F2, INS
50stroke, ischemic10.0INS, F2

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Symptoms for Hypoglycemic Coma

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Drugs & Therapeutics for Hypoglycemic Coma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hypoglycemic Coma

Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Search CenterWatch for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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34MalaCards
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MalaCards organs/tissues related to Hypoglycemic Coma:

34
Brain, Liver, Heart, Breast, Endothelial, Temporal lobe

Animal Models for Hypoglycemic Coma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypoglycemic Coma:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8VEGFA, INS, IGF2
2MP:00053678.7VEGFA, INS, IGF2
3MP:00030128.6IGF2, INS, VEGFA
4MP:00053818.4VEGFA, INS, IGF2, F2
5MP:00053908.3F2, IGF2, INS, VEGFA
6MP:00107718.3VEGFA, INS, IGF2, F2
7MP:00053808.3F2, IGF2, INS, VEGFA
8MP:00053898.3VEGFA, INS, IGF2, F2
9MP:00053858.3F2, IGF2, INS, VEGFA
10MP:00053978.3VEGFA, INS, IGF2, F2
11MP:00053888.3VEGFA, IGF2, F2
12MP:00053878.3F2, IGF2, INS, VEGFA
13MP:00053848.2VEGFA, INS, IGF2, F2
14MP:00036318.2F2, IGF2, INS, VEGFA
15MP:00053788.1F2, IGF2, INS, VEGFA
16MP:00053768.1VEGFA, INS, IGF2, F2

Publications for Hypoglycemic Coma

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53PubMed
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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Silent myocardial infarction during hypoglycemic coma. (22276266)
2012
2
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. (21056562)
2011
3
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. (21400210)
2011
4
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. (20887629)
2010
5
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. (18202087)
2008
6
Truncation of the krebs cycle during hypoglycemic coma. (18673151)
2008
7
Extensive white matter injury in hypoglycemic coma. (17389314)
2007
8
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
9
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
10
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa. (16168799)
2005
11
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. (15098777)
2004
12
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. (12971357)
2003
13
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. (12974447)
2003
14
Reversible hypoglycemic coma despite bilateral absence of the median nerve N20 evoked potential. (12771284)
2003
15
Protein ubiquitination in rat brain following hypoglycemic coma. (11165431)
2001
16
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. (11083229)
2000
17
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. (10973608)
2000
18
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. (10670909)
2000
19
Hypoglycemic coma masquerading thyrotoxic storm. (10563748)
1999
20
Glibenclamide-induced hypoglycemic coma in 51 older patients with type 2 diabetes mellitus. (10323665)
1999
21
Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive. (10362687)
1999
22
Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)
1996
23
Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. (7750077)
1995
24
Brain calcium metabolism in hypoglycemic coma. (8408320)
1993
25
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. (1731336)
1992
26
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
27
Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. (2183736)
1990
28
Extracellular pH in the rat brain during hypoglycemic coma and recovery. (2303542)
1990
29
Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. (2719056)
1989
30
Fetal heart rate in maternal hypoglycemic coma. (2860035)
1985
31
Hypoglycemic coma induced by inadvertent administration of glyburide. (6421558)
1984
32
Hypoglycemic coma due to disopyramide toxicity. (6635745)
1983
33
Ethanol-induced hypoglycemic coma in a child. (7073036)
1982
34
Hypoglycemic coma due to use of an improper battery in a commonly used insulin pump. (6927734)
1982
35
Hypoglycemic coma: don't overlook acute adrenal crisis. (6279471)
1982
36
Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy. (7396601)
1980
37
Hypoglycemic coma associated with benign pleural mesothelioma. (1113546)
1975
38
Jaundice in pregnancy (a case report of infective hepatitis in pregnancy with hypofibrinogenenia and hypoglycemic coma). (4457638)
1974
39
Cerebral metabolism in schizophrenia. Study on L-(U- 14 C) glutamine and L-(U- 14 C) glutamic acid under basal conditions and in hypoglycemic coma. (5022651)
1972
40
Changes of human somatosensory evoked response in the course of insulin hypoglycemic coma. (5394541)
1969
41
Cerebrospinal fluid pleocytosis in hypoglycemic coma. (5658451)
1968
42
Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases. (6046558)
1967
43
Hypoglycemic coma in a diabetic patient treated with tolbutamide. (5907293)
1966
44
HYPOGLYCEMIC COMA DURING SULFONYLUREA THERAPY. (14281786)
1965
45
CHLORPROPAMIDE-INDUCED HYPOGLYCEMIC COMA. (14195808)
1964
46
Analeptic action of peripheral electrical stimulation in hypoglycemic coma. (14407673)
1959
47
Hypoglycemic coma following BZ 55; report of a case. (13640693)
1959
48
An investigation of the role played by oxygen and by cellular respiration in hypoglycemic coma. (13323105)
1956
49
Hypoglycemic coma and convulsions in fasting bady lambs. (13219928)
1955
50
Irreversible post-hypoglycemic coma. (14885206)
1951

Variations for Hypoglycemic Coma

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Expression for genes affiliated with Hypoglycemic Coma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for genes affiliated with Hypoglycemic Coma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5INS, IGF2
29.5INS, IGF2
39.4IGF2, F2
4
Show member pathways
thioredoxin pathway39
9.3F2, INS
59.3INS, F2
6
Show member pathways
9.2VEGFA, IGF2
79.2IGF2, VEGFA
89.1INS, VEGFA
99.1VEGFA, INS
10
Show member pathways
Signaling Pathways in Glioblastoma39
9.1VEGFA, INS
11
Show member pathways
8.9INS, IGF2, F2
12
Show member pathways
8.9INS, IGF2, F2
13
Show member pathways
8.9INS, IGF2, F2
14
Show member pathways
8.6F2, IGF2, VEGFA
15
Show member pathways
8.5F2, INS, VEGFA
16
Show member pathways
8.1VEGFA, INS, IGF2, F2

Compounds for genes affiliated with Hypoglycemic Coma

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46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 52PharmGKB
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Compounds related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dehydroepiandrosterone sulfate469.9INS, IGF2
2nicotinamide46 1210.8INS, IGF2
32-deoxyglucose46 1210.8INS, IGF2
4c-peptide469.8IGF2, INS
5dhea469.8INS, IGF2
6androstenedione46 2510.8IGF2, INS
7levonorgestrel46 62 30 1212.8IGF2, F2
8desogestrel46 1210.8INS, F2
9carnitine469.7IGF2, INS
10cyproteroneacetate469.7F2, INS
11protamine469.7INS, F2
12hydrocortisone46 3 62 1212.7IGF2, INS
13aprotinin46 1210.7IGF2, F2
14ibmx46 62 3011.7INS, IGF2
15polyethylene glycol469.7F2, IGF2
16thyroxine46 2510.6IGF2, INS
17leucovorin46 52 1211.6IGF2, VEGFA
18gliclazide46 52 1211.5VEGFA, INS
19gefitinib46 52 1211.5VEGFA, IGF2
20irinotecan46 52 1211.5VEGFA, IGF2
21progestin469.5VEGFA, IGF2
22silymarin469.4VEGFA, F2
23calcitriol46 62 25 1212.4IGF2, F2
24lactate469.3F2, IGF2, INS
25creatinine469.3F2, IGF2, INS
26acth469.2INS, IGF2
27imatinib46 52 1211.2VEGFA, IGF2
28simvastatin46 52 62 30 25 1214.2VEGFA, F2
29octreotide46 62 30 1212.1VEGFA, INS, IGF2
30pioglitazone30 46 52 1212.1VEGFA, INS, IGF2
31prostacyclin469.1IGF2, VEGFA
32hyaluronic acid46 2510.1VEGFA, F2
33alanine469.1INS, IGF2, F2
34rapamycin469.1VEGFA, INS, IGF2
35ly294002469.1VEGFA, INS, IGF2
36suramin46 30 1211.0F2, IGF2, VEGFA
37tamoxifen46 52 30 1212.0F2, IGF2, VEGFA
38dexamethasone46 52 30 1212.0IGF2, INS, VEGFA
39heparin46 30 25 1211.9VEGFA, IGF2, F2
40estrogen468.5F2, IGF2, INS, VEGFA

GO Terms for genes affiliated with Hypoglycemic Coma

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17Gene Ontology
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Cellular components related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.3INS, F2
2platelet alpha granule lumenGO:0310939.1VEGFA, IGF2
3Golgi lumenGO:0057969.0INS, F2
4extracellular spaceGO:0056158.1VEGFA, INS, IGF2, F2
5extracellular regionGO:0055768.1F2, IGF2, INS, VEGFA

Biological processes related to Hypoglycemic Coma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:0466289.8INS, IGF2
2positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF2
3positive regulation of mitosisGO:0458409.8INS, IGF2
4positive regulation of MAPK cascadeGO:0434109.7INS, IGF2
5negative regulation of proteolysisGO:0458619.6F2, INS
6positive regulation of protein kinase B signalingGO:0518979.6IGF2, INS
7acute-phase responseGO:0069539.6INS, F2
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6INS, F2
9insulin receptor signaling pathwayGO:0082869.5INS, IGF2
10positive regulation of cell growthGO:0303079.5INS, F2
11positive regulation of protein autophosphorylationGO:0319549.5INS, VEGFA
12positive regulation of cell divisionGO:0517819.4VEGFA, IGF2
13glucose metabolic processGO:0060069.4IGF2, INS
14platelet degranulationGO:0025769.3VEGFA, IGF2
15cellular protein metabolic processGO:0442679.1F2, IGF2, INS
16regulation of cell shapeGO:0083609.0VEGFA, F2
17positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0IGF2, INS, VEGFA
18positive regulation of protein phosphorylationGO:0019348.9VEGFA, IGF2, F2
19platelet activationGO:0301688.9VEGFA, IGF2, F2
20positive regulation of cell migrationGO:0303358.8VEGFA, INS
21blood coagulationGO:0075968.8F2, IGF2, VEGFA
22positive regulation of cell proliferationGO:0082848.4VEGFA, INS, IGF2, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.5INS, IGF2
2insulin receptor bindingGO:0051589.4INS, IGF2
3hormone activityGO:0051799.2IGF2, INS
4growth factor activityGO:0080838.6VEGFA, IGF2, F2
5protein bindingGO:0055157.5VEGFA, INS, IGF2, F2, GBP3

Products for genes affiliated with Hypoglycemic Coma

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Sources for Hypoglycemic Coma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet