Aliases & Classifications for Hypoglycemic Coma

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Aliases & Descriptions for Hypoglycemic Coma:

Name: Hypoglycemic Coma 8 10 44 61
Hypoglycemic Coma Nos 8
 
Hypoglycaemic Coma 8


External Ids:

Disease Ontology8 DOID:1607
ICD9CM27 251.0

Summaries for Hypoglycemic Coma

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MalaCards based summary: Hypoglycemic Coma, also known as hypoglycemic coma nos, is related to hypoglycemia and insulinoma. An important gene associated with Hypoglycemic Coma is IGF2 (insulin-like growth factor 2 (somatomedin A)), and among its related pathways are Insulin receptor signalling cascade and Cardiac Progenitor Differentiation. The compounds dehydroepiandrosterone sulfate and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and heart, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Hypoglycemic Coma

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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.7IGF2, INS
2insulinoma30.4IGF2, INS
3hepatocellular carcinoma29.9VEGFA, F2, IGF2, INS
4cerebritis10.6
5anorexia nervosa10.5
6laron dwarfism10.4IGF2
7insulin autoimmune syndrome10.4
8central retinal vein occlusion10.4VEGFA
9diabetic macular edema10.4VEGFA
10meningioma, familial10.3IGF2
11hepatitis10.3
12glycogen storage disease10.2
13mucinous cystadenocarcinoma10.2
14cystadenocarcinoma10.2
15hyperinsulinemic hypoglycemia, familial, 210.2INS, IGF2
16fetal macrosomia10.2INS, IGF2
17growth hormone deficiency10.2INS, IGF2
18hyperandrogenism10.2INS, IGF2
19acromegaly10.2IGF2, INS
20schizophrenia10.2
21hyperinsulinemic hypoglycemia, familial, 710.2
22hyperinsulinemic hypoglycemia, familial, 410.2
23hyperinsulinemic hypoglycemia, familial, 310.2
24hyperinsulinemic hypoglycemia, familial, 110.2
25hyperinsulinemic hypoglycemia, familial, 510.2
26myocardial infarction10.2
27acyl-coa dehydrogenase, medium chain, deficiency of10.2
28glutaric acidemia iic10.2
29hyperinsulinism-hyperammonemia syndrome10.2
30cerebral hemorrhage10.2
31hepatitis b10.2
32hydrocephalus10.2
33diabetic ketoacidosis10.2
34normal pressure hydrocephalus10.2
35benign pleural mesothelioma10.2
36neuronitis10.2
37central pontine myelinolysis10.2
38silent myocardial infarction10.2
39ischemia10.2
40peritonitis10.2
41acth deficiency10.2
42phyllode tumor10.2
43endotheliitis10.2
44mesothelioma10.2
45polycystic ovary syndrome10.1INS, IGF2
46microvascular complications of diabetes 510.1VEGFA, INS
47blindness10.1INS, VEGFA
48hyperinsulinism10.1IGF2, INS
49diabetes mellitus, insulin-dependent10.1INS, IGF2
50proteinuria10.1VEGFA, INS

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to hypoglycemic coma

Symptoms for Hypoglycemic Coma

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Drugs & Therapeutics for Hypoglycemic Coma

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Drug clinical trials:

Search ClinicalTrials for Hypoglycemic Coma

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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MalaCards organs/tissues related to Hypoglycemic Coma:

31
Brain, Liver, Heart, Breast, Endothelial, Temporal lobe

Animal Models for Hypoglycemic Coma or affiliated genes

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MGI Mouse Phenotypes related to Hypoglycemic Coma:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8IGF2, VEGFA, INS
2MP:00053678.7IGF2, INS, VEGFA
3MP:00030128.6INS, IGF2, VEGFA
4MP:00053818.4F2, IGF2, INS, VEGFA
5MP:00053908.3F2, IGF2, INS, VEGFA
6MP:00107718.3IGF2, INS, VEGFA, F2
7MP:00053808.3IGF2, VEGFA, INS, F2
8MP:00053898.3INS, F2, VEGFA, IGF2
9MP:00053858.3IGF2, F2, INS, VEGFA
10MP:00053978.3VEGFA, IGF2, F2, INS
11MP:00053888.3IGF2, F2, VEGFA
12MP:00053878.3INS, F2, IGF2, VEGFA
13MP:00053848.2IGF2, INS, VEGFA, F2
14MP:00036318.2VEGFA, INS, F2, IGF2
15MP:00053788.1VEGFA, INS, IGF2, F2
16MP:00053768.1INS, VEGFA, IGF2, F2

Publications for Hypoglycemic Coma

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Articles related to Hypoglycemic Coma:

(show top 50)    (show all 102)
idTitleAuthorsYear
1
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. (25289063)
2014
2
Recurrent Hypoglycemic Coma as the Initial and Single Clinical Manifestation of Advanced Hepatocellular Carcinoma. (25407746)
2014
3
Silent myocardial infarction during hypoglycemic coma. (22276266)
2012
4
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. (21056562)
2011
5
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. (20887629)
2010
6
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. (18202087)
2008
7
Truncation of the krebs cycle during hypoglycemic coma. (18673151)
2008
8
Extensive white matter injury in hypoglycemic coma. (17389314)
2007
9
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
10
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
11
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. (15098777)
2004
12
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. (12971357)
2003
13
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. (12974447)
2003
14
Reversible hypoglycemic coma despite bilateral absence of the median nerve N20 evoked potential. (12771284)
2003
15
Protein ubiquitination in rat brain following hypoglycemic coma. (11165431)
2001
16
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma. (11083229)
2000
17
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma. (10973608)
2000
18
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. (10670909)
2000
19
Hypoglycemic coma masquerading thyrotoxic storm. (10563748)
1999
20
Glibenclamide-induced hypoglycemic coma in 51 older patients with type 2 diabetes mellitus. (10323665)
1999
21
Hypoketotic hypoglycemic coma in a 21-month-old child. (10459098)
1999
22
Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive. (10362687)
1999
23
Anorexia nervosa with recurrent hypoglycemic coma and cerebral hemorrhage. (8842763)
1996
24
Bilateral temporal lobe MRI changes in uncomplicated hypoglycemic coma. (7750077)
1995
25
Brain calcium metabolism in hypoglycemic coma. (8408320)
1993
26
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. (1731336)
1992
27
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
28
Hypoglycemic coma in anorexia nervosa. Case report and review of the literature. (2183736)
1990
29
Extracellular pH in the rat brain during hypoglycemic coma and recovery. (2303542)
1990
30
Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. (2719056)
1989
31
Fetal heart rate in maternal hypoglycemic coma. (2860035)
1985
32
Hypoglycemic coma induced by inadvertent administration of glyburide. (6421558)
1984
33
Hypoglycemic coma due to disopyramide toxicity. (6635745)
1983
34
Ethanol-induced hypoglycemic coma in a child. (7073036)
1982
35
Hypoglycemic coma due to use of an improper battery in a commonly used insulin pump. (6927734)
1982
36
Hypoglycemic coma: don't overlook acute adrenal crisis. (6279471)
1982
37
Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy. (7396601)
1980
38
Hypoglycemic coma associated with benign pleural mesothelioma. (1113546)
1975
39
Jaundice in pregnancy (a case report of infective hepatitis in pregnancy with hypofibrinogenenia and hypoglycemic coma). (4457638)
1974
40
Cerebral metabolism in schizophrenia. Study on L-(U- 14 C) glutamine and L-(U- 14 C) glutamic acid under basal conditions and in hypoglycemic coma. (5022651)
1972
41
Changes of human somatosensory evoked response in the course of insulin hypoglycemic coma. (5394541)
1969
42
Cerebrospinal fluid pleocytosis in hypoglycemic coma. (5658451)
1968
43
Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases. (6046558)
1967
44
Hypoglycemic coma in a diabetic patient treated with tolbutamide. (5907293)
1966
45
HYPOGLYCEMIC COMA DURING SULFONYLUREA THERAPY. (14281786)
1965
46
CHLORPROPAMIDE-INDUCED HYPOGLYCEMIC COMA. (14195808)
1964
47
Analeptic action of peripheral electrical stimulation in hypoglycemic coma. (14407673)
1959
48
Hypoglycemic coma following BZ 55; report of a case. (13640693)
1959
49
Hypoglycemic coma and convulsions in fasting bady lambs. (13219928)
1955
50
Irreversible post-hypoglycemic coma. (14885206)
1951

Variations for Hypoglycemic Coma

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Expression for genes affiliated with Hypoglycemic Coma

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Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for genes affiliated with Hypoglycemic Coma

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Pathways related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5INS, IGF2
29.5INS, IGF2
39.4IGF2, F2
4
Show member pathways
thioredoxin pathway36
9.3F2, INS
59.3INS, F2
6
Show member pathways
9.2VEGFA, IGF2
79.2IGF2, VEGFA
89.1INS, VEGFA
99.1VEGFA, INS
10
Show member pathways
Signaling Pathways in Glioblastoma36
9.1VEGFA, INS
11
Show member pathways
8.9INS, IGF2, F2
12
Show member pathways
8.9INS, IGF2, F2
13
Show member pathways
8.9INS, IGF2, F2
14
Show member pathways
8.6F2, IGF2, VEGFA
15
Show member pathways
8.5F2, INS, VEGFA
16
Show member pathways
8.1VEGFA, INS, IGF2, F2

Compounds for genes affiliated with Hypoglycemic Coma

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Compounds related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dehydroepiandrosterone sulfate449.9IGF2, INS
2nicotinamide44 1110.8IGF2, INS
32-deoxyglucose44 1110.8INS, IGF2
4c-peptide449.8IGF2, INS
5dhea449.8IGF2, INS
6androstenedione44 2410.8IGF2, INS
7levonorgestrel44 60 28 1112.8IGF2, F2
8carnitine449.8IGF2, INS
9desogestrel44 1110.8INS, F2
10cyproteroneacetate449.7F2, INS
11protamine449.7INS, F2
12hydrocortisone44 1 60 1112.7INS, IGF2
13aprotinin44 1110.7F2, IGF2
14ibmx44 60 2811.7IGF2, INS
15polyethylene glycol449.6F2, IGF2
16thyroxine44 2410.6INS, IGF2
17leucovorin44 50 1111.6VEGFA, IGF2
18gliclazide44 50 1111.5INS, VEGFA
19gefitinib44 50 1111.5VEGFA, IGF2
20irinotecan44 50 1111.5VEGFA, IGF2
21progestin449.5VEGFA, IGF2
22silymarin449.4VEGFA, F2
23calcitriol44 60 24 1112.4IGF2, F2
24lactate449.3F2, IGF2, INS
25creatinine449.3F2, IGF2, INS
26imatinib44 50 1111.2IGF2, VEGFA
27acth449.2INS, IGF2
28simvastatin44 50 60 28 24 1114.2VEGFA, F2
29octreotide44 60 28 1112.1INS, VEGFA, IGF2
30pioglitazone28 44 50 1112.1VEGFA, INS, IGF2
31alanine449.1INS, F2, IGF2
32prostacyclin449.1IGF2, VEGFA
33hyaluronic acid44 2410.1VEGFA, F2
34rapamycin449.1IGF2, VEGFA, INS
35ly294002449.1VEGFA, INS, IGF2
36suramin44 28 1111.0VEGFA, IGF2, F2
37tamoxifen44 50 28 1112.0F2, VEGFA, IGF2
38dexamethasone44 50 28 1112.0IGF2, INS, VEGFA
39heparin44 28 24 1111.9F2, VEGFA, IGF2
40estrogen448.5F2, IGF2, INS, VEGFA

GO Terms for genes affiliated with Hypoglycemic Coma

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Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.3INS, F2
2platelet alpha granule lumenGO:00310939.1VEGFA, IGF2
3Golgi lumenGO:00057969.0INS, F2
4extracellular spaceGO:00056158.1VEGFA, INS, IGF2, F2
5extracellular regionGO:00055768.1F2, IGF2, INS, VEGFA

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:00466289.8INS, IGF2
2positive regulation of glycogen biosynthetic processGO:00457259.8INS, IGF2
3positive regulation of mitosisGO:00458409.8INS, IGF2
4positive regulation of MAPK cascadeGO:00434109.7INS, IGF2
5negative regulation of proteolysisGO:00458619.6F2, INS
6positive regulation of protein kinase B signalingGO:00518979.6IGF2, INS
7acute-phase responseGO:00069539.6INS, F2
8positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6INS, F2
9insulin receptor signaling pathwayGO:00082869.5INS, IGF2
10positive regulation of cell growthGO:00303079.5INS, F2
11positive regulation of protein autophosphorylationGO:00319549.5INS, VEGFA
12positive regulation of cell divisionGO:00517819.4VEGFA, IGF2
13glucose metabolic processGO:00060069.4IGF2, INS
14platelet degranulationGO:00025769.3VEGFA, IGF2
15cellular protein metabolic processGO:00442679.1F2, IGF2, INS
16regulation of cell shapeGO:00083609.0VEGFA, F2
17positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.0IGF2, INS, VEGFA
18positive regulation of protein phosphorylationGO:00019348.9VEGFA, IGF2, F2
19platelet activationGO:00301688.9VEGFA, IGF2, F2
20positive regulation of cell migrationGO:00303358.8VEGFA, INS
21blood coagulationGO:00075968.8F2, IGF2, VEGFA
22positive regulation of cell proliferationGO:00082848.4VEGFA, INS, IGF2, F2

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.5INS, IGF2
2insulin receptor bindingGO:00051589.4INS, IGF2
3hormone activityGO:00051799.2IGF2, INS
4growth factor activityGO:00080838.6VEGFA, IGF2, F2
5protein bindingGO:00055157.5VEGFA, INS, IGF2, F2, GBP3

Sources for Hypoglycemic Coma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet