Aliases & Classifications for Hypogonadism

MalaCards integrated aliases for Hypogonadism:

Name: Hypogonadism 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1924
MeSH 42 D007006
NCIt 47 C9227
SNOMED-CT 64 48130008
UMLS 69 C0020619

Summaries for Hypogonadism

Disease Ontology : 12 A gonadal disease that is characterized by diminished functional activity of the gonads.

MalaCards based summary : Hypogonadism is related to hypogonadotropic hypogonadism and cerebellar ataxia and hypogonadotropic hypogonadism. An important gene associated with Hypogonadism is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and endocrine/exocrine gland

Wikipedia : 72 Hypogonadism means diminished functional activity of the gonads—the testes in males or the ovaries in... more...

Related Diseases for Hypogonadism

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
id Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 12.2
2 cerebellar ataxia and hypogonadotropic hypogonadism 12.1
3 hypogonadotropic hypogonadism 7 without anosmia 12.1
4 hypogonadotropic hypogonadism 1 with or without anosmia 12.1
5 hypogonadotropic hypogonadism 13 with or without anosmia 12.0
6 hypogonadotropic hypogonadism 12 with or without anosmia 12.0
7 hypogonadotropic hypogonadism 15 with or without anosmia 12.0
8 hypogonadotropic hypogonadism 16 with or without anosmia 12.0
9 hypogonadotropic hypogonadism 11 with or without anosmia 12.0
10 hypogonadotropic hypogonadism 10 with or without anosmia 12.0
11 hypogonadotropic hypogonadism 9 with or without anosmia 12.0
12 hypogonadotropic hypogonadism 8 with or without anosmia 12.0
13 hypogonadotropic hypogonadism 4 with or without anosmia 12.0
14 hypogonadotropic hypogonadism 6 with or without anosmia 12.0
15 hypogonadotropic hypogonadism 18 with or without anosmia 12.0
16 hypogonadotropic hypogonadism 5 with or without anosmia 12.0
17 hypogonadotropic hypogonadism 14 with or without anosmia 12.0
18 hypogonadotropic hypogonadism 3 with or without anosmia 12.0
19 hypogonadotropic hypogonadism 17 with or without anosmia 12.0
20 hypogonadotropic hypogonadism 21 with anosmia 12.0
21 hypogonadotropic hypogonadism 22, with or without anosmia 12.0
22 hypogonadotropic hypogonadism 19 with or without anosmia 12.0
23 hypogonadotropic hypogonadism 20 with or without anosmia 12.0
24 hypogonadotropic hypogonadism 2 with or without anosmia 12.0
25 hypogonadotropic hypogonadism 23 with or without anosmia 12.0
26 ataxia - hypogonadism - choroidal dystrophy 12.0
27 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
28 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
29 hypogonadotropic hypogonadism 24 without anosmia 11.9
30 deafness-hypogonadism syndrome 11.9
31 moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism 11.8
32 hydrocephalus obesity hypogonadism 11.8
33 kallmann syndrome 11.8
34 normosmic congenital hypogonadotropic hypogonadism 11.7
35 malouf syndrome 11.7
36 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.7
37 muscular dystrophy, congenital, with infantile cataract and hypogonadism 11.6
38 hypergonadotropic hypogonadism and partial alopecia 11.6
39 hypogonadism, male, with mental retardation and skeletal anomalies 11.6
40 alopecia-mental retardation syndrome with convulsions and hypergonadotropic hypogonadism 11.6
41 mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity 11.6
42 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.6
43 hypogonadism-cataract syndrome 11.6
44 microcephaly hypergonadotropic hypogonadism short stature 11.6
45 moebius axonal neuropathy hypogonadism 11.6
46 boucher-neuhauser syndrome 11.6
47 hypogonadism cardiomyopathy 11.5
48 hypogonadism mitral valve prolapse mental retardation 11.5
49 hypogonadism primary partial alopecia 11.5
50 cardiomyopathy hypogonadism metabolic anomalies 11.5

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to Hypogonadism

Symptoms & Phenotypes for Hypogonadism

GenomeRNAi Phenotypes related to Hypogonadism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.04 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.04 FGF8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.04 FGF17
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.04 SPRY4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.04 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.04 FGFR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.04 FGF8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.04 KISS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.04 KISS1R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.04 FGF8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.04 SPRY4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.04 KISS1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.04 KISS1R LHB FGFR1 KISS1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.04 FGF17
15 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.04 FGFR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.04 SPRY4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.04 LHB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.04 FGF8 KISS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.04 SPRY4
20 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.04 LHB
21 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.04 FGF17
22 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.04 FGF8
23 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.04 FGFR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.04 FGF8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.04 FGFR1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.04 LHB SPRY4 FGF17 FGF8
27 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.04 FGFR1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.04 SPRY4
29 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.04 SPRY4 FGF17
30 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.04 KISS1R
31 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.04 FGF8 KISS1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.04 SPRY4
33 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.04 FGFR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.04 KISS1R
35 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.04 FGFR1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.04 FGF8
37 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.04 FGF17
38 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.04 LHB

MGI Mouse Phenotypes related to Hypogonadism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.24 FGFR1 FSHB GNRH1 GNRHR KISS1 KISS1R
2 growth/size/body region MP:0005378 10.13 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
3 homeostasis/metabolism MP:0005376 10.13 CHD7 DUSP6 FGF8 FGFR1 FSHB GNRH1
4 digestive/alimentary MP:0005381 10.06 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
5 nervous system MP:0003631 9.9 NSMF PROK2 PROKR2 SPRY4 CHD7 FGF17
6 renal/urinary system MP:0005367 9.5 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
7 reproductive system MP:0005389 9.5 CHD7 FGF8 FGFR1 FSHB GNRH1 GNRHR

Drugs & Therapeutics for Hypogonadism

Drugs for Hypogonadism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
3
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5281010 5311071
4
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
5
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 152945 6918296
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757
7
Progesterone Approved, Vet_approved Phase 4,Phase 3 57-83-0 5994
8
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
9
Menotropins Approved Phase 4 61489-71-2, 9002-68-0 5360545
10
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 120511-73-1 2187
11
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
12
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
13
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
14
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
15
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
16 Chorionic Gonadotropin Phase 4,Phase 3
17 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
25 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
26 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
27 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28
Testosterone enanthate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 315-37-7 9416
29 Testosterone undecanoate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Vardenafil Dihydrochloride Phase 4
31 Vasodilator Agents Phase 4,Early Phase 1
32 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
34 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 insulin Phase 4,Phase 3,Phase 2,Phase 1
38 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1
39 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
40 Micronutrients Phase 4,Phase 3,Phase 2
41 Mitogens Phase 4
42 Trace Elements Phase 4,Phase 3,Phase 2
43 Vitamins Phase 4,Phase 3,Phase 2
44 decanoic acid Phase 4
45 Contraceptive Agents Phase 4,Phase 3,Phase 2,Early Phase 1
46 Luteolytic Agents Phase 4
47 Triptorelin Pamoate Phase 4
48 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Fenugreek seed meal Phase 4

Interventional clinical trials:

(show top 50) (show all 331)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4 Pulsatile Gonadotropin Releasing Hormone;Human chorionic gonadotropin;Urinary Follicle-Stimulating Hormone
2 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4 Testosterone
3 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
4 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4 androgel;androgel 10g;placebo
5 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4 Oral testosterone undecanoate;Transdermal testosterone gel (AndroGel)
7 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
8 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4 Testosterone enanthate (Sustanon 250 mg);Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU);Testosteron gel (Testojel 50 mg)
9 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4 Sustanon
10 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4 Testosteron
11 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4 Testosterone 250mg injection;Testosteron 50 mg transdermal gel
12 Sequential Therapy for Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4 Traditional intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH plus zinc
13 Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment Completed NCT02111434 Phase 4 Testosterone
14 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4 Testosterone
15 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4 Testogel 50 mg transdermal gel;Testosterone 250mg injection
16 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4 Testosteron 250mg injection;Testosterone 50mg transdermal application
17 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
18 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4 testosterone;placebo
19 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism Completed NCT02102646 Phase 4 Triptorelin
20 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4 AndroGel (testosterone gel) 1%
21 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
22 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4 Dutasteride;Testosterone gel;Placebo dutasteride
23 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
24 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
25 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4 Topical Testosterone Solution
26 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4 dutasteride;placebo
27 Effect of Testosterone Replacement on Insulin Resistance Completed NCT00487734 Phase 4 Placebo for testosterone gel
28 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
29 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4 Testosterone;0.9% saline
30 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
31 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
32 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
33 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4 Testosterone;Placebo
34 Aripiprazole and Prolactin Study Completed NCT01085383 Phase 4 Aripiprazole
35 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
36 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
37 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
38 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Recruiting NCT02880280 Phase 4 Human Menopausal Gonadotropin;Human Chorionic Gonadotropin
39 Vitamin D Treatment and Hypogonadism in Men Recruiting NCT01748370 Phase 4 Vitamin D supplementation in hypogonadal men;Vitamin D supplementation in eugonadal men;Placebo hypogonadal;Placebo eugonadal
40 Testosterone Therapy in Hypogonadal Men Treated With Opioids Recruiting NCT02433730 Phase 4 Testosterone;placebo
41 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Recruiting NCT02959853 Phase 4 Anastrazole
42 Subcutaneous vs. Intramuscular Testosterone Recruiting NCT03091348 Phase 4 Testosterone
43 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos
44 Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ Active, not recruiting NCT02937740 Phase 4 NATESTO Testosterone Nasal Gel
45 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
46 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Active, not recruiting NCT02408445 Phase 4 testosterone cypionate 200mg/ml
47 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Not yet recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
48 NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) Terminated NCT01092858 Phase 4 Testosterone Undeconate (Nebido, BAY86-5037);Placebo
49 Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L]) Terminated NCT00328926 Phase 4 Luveris® 75 IU;Luveris® 25 IU;Placebo;Recombinant human follicle stimulating hormone (r-hFSH);Recombinant human chorionic gonadotropin (r-hCG)
50 TOM: Testosterone in Older Men With Sarcopenia Terminated NCT00240981 Phase 4 Topical testosterone gel 1% (active formulation);Topical gel (placebo formulation)

Search NIH Clinical Center for Hypogonadism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypogonadism

Genetic Tests for Hypogonadism

Genetic tests related to Hypogonadism:

id Genetic test Affiliating Genes
1 Hypogonadism 29

Anatomical Context for Hypogonadism

MalaCards organs/tissues related to Hypogonadism:

39
Bone, Prostate, Testes, Pituitary, Ovary, Endothelial, Brain

Publications for Hypogonadism

Articles related to Hypogonadism:

(show top 50) (show all 1163)
id Title Authors Year
1
Long-Term Follow-Up of Primary Medical Versus Surgical Treatment of Prolactinomas in Men: Effects on Hyperprolactinemia, Hypogonadism, and Bone Health. ( 27773859 )
2017
2
Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men. ( 28717276 )
2017
3
Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy. ( 28084147 )
2017
4
Developing and evaluating rare disease educational materials co-created by expert clinicians and patients: the paradigm of congenital hypogonadotropic hypogonadism. ( 28320476 )
2017
5
Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME). ( 28781213 )
2017
6
Psychometric Evaluation of the Hypogonadism Impact of Symptoms Questionnaire Short Form (HIS-Q-SF). ( 28760247 )
2017
7
Reversal of hypogonadotropic hypogonadism with spontaneous pregnancy in beta-thalassaemia major with transfusional haemosiderosis. ( 28830631 )
2017
8
HIV and hypogonadism: a new challenge for young-aged and middle-aged men on effective antiretroviral therapy. ( 28081039 )
2017
9
A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. ( 28284037 )
2017
10
Clinical and genetic features of 64 young male paediatric patients with congenital hypogonadotropic hypogonadism. ( 28833369 )
2017
11
Hypogonadotropic hypogonadism in a female patient with congenital arhinia. ( 27941181 )
2017
12
Bone mineral density in older patients with never-treated congenital hypogonadotropic hypogonadism. ( 28577250 )
2017
13
Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea. ( 28920756 )
2017
14
Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism. ( 28485664 )
2017
15
Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male. ( 28583920 )
2017
16
Delayed treatment of undescended testes may promote hypogonadism and infertility. ( 28070708 )
2017
17
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone I^-subunit gene. ( 28092701 )
2017
18
Switch to restoration therapy in a testosterone treated central hypogonadism with erythrocytosis. ( 28721216 )
2017
19
Boucher NeuhAouser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. ( 27866050 )
2017
20
Clinical Characteristics, Health Care Utilization and Costs Among Men with Primary or Secondary Hypogonadism in a US Commercially Insured Population. ( 27939338 )
2017
21
Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism. ( 28698240 )
2017
22
Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. ( 28931393 )
2017
23
Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism. ( 28476224 )
2017
24
Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). ( 28067604 )
2017
25
Anti-MA1llerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH. ( 28324034 )
2017
26
Characteristics of a nationwide cohort of patients presenting with Isolated Hypogonadotropic Hypogonadism (IHH). ( 28882981 )
2017
27
Late-onset hypogonadism. ( 28721133 )
2017
28
Hypogonadism in mitochondrial disorders. ( 28549633 )
2017
29
Hypogonadism with Normal Serum Testosterone. ( 28751320 )
2017
30
FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split-Hand/Foot Malformation: Implications for the Promoter Region. ( 28087897 )
2017
31
Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1. ( 28160246 )
2017
32
Hypogonadotropic hypogonadism in human immunodeficiency virus-infected men: uncommonly low testosterone levels. ( 28924485 )
2017
33
GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism. ( 28611058 )
2017
34
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
35
Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism. ( 28870428 )
2017
36
Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. ( 28694969 )
2017
37
Approaches to male hypogonadism in primary care. ( 28085783 )
2017
38
CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism. ( 28324054 )
2017
39
Is hypogonadism the cause of penile self-amputation in a patient with prior testes self-mutilation? ( 28885657 )
2017
40
Anosmia with hypogonadism: but NOT Kallmann syndrome. ( 28416537 )
2017
41
Similarity of female central (hypogonadotropic) hypogonadism and postmenopause. ( 28438051 )
2017
42
Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center. ( 27927844 )
2017
43
The Utility of Sex Hormone Binding Globulin in Hypogonadism and Infertile Males. ( 28087298 )
2017
44
KLB, encoding I^-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. ( 28754744 )
2017
45
Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism. ( 28915117 )
2017
46
Long-Term Testosterone Therapy Improves Urinary and Sexual Function and Quality of Life in Men with Hypogonadism: Results from a Propensity Matched Subgroup of a Controlled Registry Study. ( 28728990 )
2017
47
Does Testosterone Replacement Therapy Promote an Augmented Risk of Thrombotic Events in Thalassemia Major Male Patients with Hypogonadism? ( 28670553 )
2017
48
SOX2 nonsense mutation in a patient clinically diagnosed with non-syndromic hypogonadotropic hypogonadism. ( 28659543 )
2017
49
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. ( 27595632 )
2016
50
Should psoriasis be considered a risk factor for hypogonadism in male patients? A monocentric, prospective, observational pilot study. ( 27556231 )
2016

Variations for Hypogonadism

Expression for Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for Hypogonadism

Pathways related to Hypogonadism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 ANOS1 DUSP6 FGF17 FGF8 FGFR1 FSHB
2
Show member pathways
13.17 FSHB GNRH1 GNRHR KISS1 KISS1R LHB
3
Show member pathways
12.42 FGF17 FGF8 FGFR1 GNRH1 LHB
4
Show member pathways
12.28 ANOS1 FGF17 FGF8 FGFR1
5
Show member pathways
11.96 ANOS1 FGF17 FGF8 FGFR1
6
Show member pathways
11.57 FGF17 FGF8 FGFR1
7 11.34 FGF17 FGF8 FGFR1 GNRH1 LHB
8 11.2 FSHB LHB LHCGR
9 10.14 FSHB GNRH1 GNRHR LHB LHCGR

GO Terms for Hypogonadism

Cellular components related to Hypogonadism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 ANOS1 FGF17 FGF8 FGFR1 FSHB GNRH1

Biological processes related to Hypogonadism according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 FGF17 FGF8 FGFR1 FSHB PROK2
2 cell-cell signaling GO:0007267 9.93 FGF17 FSHB GNRH1 LHB
3 MAPK cascade GO:0000165 9.9 DUSP6 FGF17 FGF8 FGFR1
4 phosphatidylinositol-mediated signaling GO:0048015 9.8 FGF17 FGF8 FGFR1
5 male gonad development GO:0008584 9.79 LHB LHCGR NR0B1
6 phosphatidylinositol phosphorylation GO:0046854 9.79 FGF17 FGF8 FGFR1
7 female pregnancy GO:0007565 9.77 FSHB GNRH1 TAC3
8 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.7 FGF17 FGF8 FGFR1
9 inner ear morphogenesis GO:0042472 9.67 CHD7 FGF8 FGFR1
10 peptide hormone processing GO:0016486 9.64 FSHB LHB
11 male genitalia development GO:0030539 9.63 FGF8 LHCGR
12 regulation of osteoclast differentiation GO:0045670 9.61 FSHB LHCGR
13 aorta morphogenesis GO:0035909 9.58 CHD7 FGF8
14 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.58 FGF17 FGF8 FGFR1
15 gonad development GO:0008406 9.57 FGF8 NR0B1
16 generation of neurons GO:0048699 9.56 FGF8 FGFR1
17 G-protein coupled receptor signaling pathway GO:0007186 9.56 GNRHR KISS1 KISS1R LHB LHCGR PROK2
18 branching involved in salivary gland morphogenesis GO:0060445 9.55 FGF8 FGFR1
19 male sex determination GO:0030238 9.54 GNRH1 NR0B1
20 organ induction GO:0001759 9.51 FGF8 FGFR1
21 tachykinin receptor signaling pathway GO:0007217 9.48 TAC3 TACR3
22 cellular response to gonadotropin stimulus GO:0071371 9.46 LHCGR NSMF
23 neuropeptide signaling pathway GO:0007218 9.46 KISS1R PROK2 PROKR2 TAC3
24 hormone-mediated signaling pathway GO:0009755 9.43 FSHB LHB LHCGR
25 follicle-stimulating hormone signaling pathway GO:0042699 9.37 FSHB LHCGR
26 progesterone biosynthetic process GO:0006701 9.32 FSHB LHB
27 fibroblast growth factor receptor signaling pathway GO:0008543 8.92 ANOS1 FGF17 FGF8 FGFR1
28 signal transduction GO:0007165 10.09 FGF17 FSHB GNRH1 GNRHR KISS1R LHB

Molecular functions related to Hypogonadism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGF17 FGF8 FGFR1
2 hormone activity GO:0005179 9.43 FSHB GNRH1 LHB
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF17 FGF8 FGFR1
4 G-protein coupled peptide receptor activity GO:0008528 9.32 KISS1R LHCGR
5 protein-hormone receptor activity GO:0016500 8.96 GNRHR LHCGR
6 1-phosphatidylinositol-3-kinase activity GO:0016303 8.8 FGF17 FGF8 FGFR1

Sources for Hypogonadism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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