Aliases & Classifications for Hypogonadism

MalaCards integrated aliases for Hypogonadism:

Name: Hypogonadism 12 72 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1924
MeSH 41 D007006
NCIt 46 C9227
SNOMED-CT 64 48130008
UMLS 69 C0020619

Summaries for Hypogonadism

Disease Ontology : 12 A gonadal disease that is characterized by diminished functional activity of the gonads.

MalaCards based summary : Hypogonadism is related to hypogonadotropic hypogonadism 23 without anosmia and hypogonadotropic hypogonadism 7 with or without anosmia. An important gene associated with Hypogonadism is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Hypogonadism means diminished functional activity of the gonads—the testes or the ovaries —that may... more...

Related Diseases for Hypogonadism

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 457)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 33.7 GNRH1 GNRHR LHB
2 hypogonadotropic hypogonadism 7 with or without anosmia 33.6 DUSP6 FGF17 GNRH1 GNRHR SPRY4
3 hypogonadotropism 31.8 GNRH1 KISS1 KISS1R
4 anosmia 30.1 ANOS1 FGF17 FGFR1 PROKR2 SPRY4
5 infertility 29.6 FSHB GNRH1 LHB LHCGR
6 normosmic congenital hypogonadotropic hypogonadism 29.2 ANOS1 CHD7 DUSP6 FGF17 FGF8 FGFR1
7 charge syndrome 29.1 ANOS1 CHD7 FGF8 FGFR1 GNRHR PROK2
8 cryptorchidism, unilateral or bilateral 29.1 ANOS1 CHD7 FGFR1 GNRH1 GNRHR PROK2
9 precocious puberty 29.1 GNRH1 KISS1 KISS1R LHCGR
10 central precocious puberty 29.0 GNRH1 KISS1 KISS1R
11 kallmann syndrome 28.9 ANOS1 CHD7 DUSP6 FGF17 FGF8 FGFR1
12 amenorrhea 28.9 FSHB GNRH1 LHB LHCGR
13 hypogonadotropic hypogonadism 28.9 ANOS1 CHD7 DUSP6 FGF17 FGF8 FGFR1
14 hypogonadotropic hypogonadism 2 with or without anosmia 12.2
15 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 12.2
16 ataxia - hypogonadism - choroidal dystrophy 12.2
17 hypogonadotropic hypogonadism 1 with or without anosmia 12.2
18 hypogonadotropic hypogonadism 10 with or without anosmia 12.2
19 hypogonadotropic hypogonadism 11 with or without anosmia 12.2
20 hypogonadotropic hypogonadism 12 with or without anosmia 12.2
21 hypogonadotropic hypogonadism 13 with or without anosmia 12.2
22 hypogonadotropic hypogonadism 15 with or without anosmia 12.2
23 hypogonadotropic hypogonadism 16 with or without anosmia 12.2
24 hypogonadotropic hypogonadism 21 with or without anosmia 12.2
25 hypogonadotropic hypogonadism 22 with or without anosmia 12.2
26 hypogonadotropic hypogonadism 8 with or without anosmia 12.2
27 hypogonadotropic hypogonadism 9 with or without anosmia 12.2
28 hypogonadotropic hypogonadism 14 with or without anosmia 12.2
29 hypogonadotropic hypogonadism 17 with or without anosmia 12.2
30 hypogonadotropic hypogonadism 18 with or without anosmia 12.2
31 hypogonadotropic hypogonadism 19 with or without anosmia 12.2
32 hypogonadotropic hypogonadism 20 with or without anosmia 12.2
33 hypogonadism, male 12.1
34 hypogonadotropic hypogonadism 3 with or without anosmia 12.1
35 hypogonadotropic hypogonadism 4 with or without anosmia 12.1
36 hypogonadotropic hypogonadism 5 with or without anosmia 12.1
37 hypogonadotropic hypogonadism 6 with or without anosmia 12.1
38 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.1
39 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.1
40 hypogonadotropic hypogonadism 24 without anosmia 12.0
41 deafness-hypogonadism syndrome 12.0
42 moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism 12.0
43 hydrocephalus obesity hypogonadism 12.0
44 intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome 11.9
45 retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome 11.9
46 gordon holmes syndrome 11.9
47 hypogonadism-cataract syndrome 11.8
48 hypergonadotropic hypogonadism and partial alopecia 11.8
49 muscular dystrophy, congenital, with infantile cataract and hypogonadism 11.8
50 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.8

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to Hypogonadism

Symptoms & Phenotypes for Hypogonadism

GenomeRNAi Phenotypes related to Hypogonadism according to GeneCards Suite gene sharing:

25 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.04 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.04 FGF8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.04 FGF17
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.04 SPRY4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.04 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.04 FGFR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.04 FGF8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.04 KISS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.04 KISS1R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.04 FGF8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.04 SPRY4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.04 KISS1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.04 KISS1 LHB KISS1R FGFR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.04 FGF17
15 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.04 FGFR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.04 SPRY4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.04 LHB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.04 FGF8 KISS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.04 SPRY4
20 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.04 LHB
21 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.04 FGF17
22 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.04 FGF8
23 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.04 FGFR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.04 FGF8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.04 FGFR1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.04 LHB SPRY4 FGF17 FGF8
27 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.04 FGFR1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.04 SPRY4
29 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.04 SPRY4 FGF17
30 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.04 KISS1R
31 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.04 FGF8 KISS1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.04 SPRY4
33 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.04 FGFR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.04 KISS1R
35 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.04 FGFR1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.04 FGF8
37 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.04 FGF17
38 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.04 LHB

MGI Mouse Phenotypes related to Hypogonadism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.24 CHD7 FGF8 FGFR1 FSHB GNRH1 GNRHR
2 growth/size/body region MP:0005378 10.13 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
3 homeostasis/metabolism MP:0005376 10.13 PROKR2 TAC3 TACR3 CHD7 DUSP6 FGF8
4 digestive/alimentary MP:0005381 10.06 CHD7 FGF8 FGFR1 GNRH1 GNRHR KISS1
5 nervous system MP:0003631 9.93 FGFR1 GNRH1 KISS1 KISS1R LHCGR NSMF
6 renal/urinary system MP:0005367 9.5 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
7 reproductive system MP:0005389 9.5 TAC3 TACR3 CHD7 FGF8 FGFR1 FSHB

Drugs & Therapeutics for Hypogonadism

Drugs for Hypogonadism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
3
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5311071 5281010
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
5
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 6918296 152945
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757
7
Progesterone Approved, Vet_approved Phase 4,Phase 3 57-83-0 5994
8
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
9
Menotropins Approved Phase 4 9002-68-0, 61489-71-2 5360545
10
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 120511-73-1 2187
11
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 4091 14219
12
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
13
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 10883523 5280795 6221
14
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
15
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
16 Chorionic Gonadotropin Phase 4,Phase 3,Phase 2
17 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
25 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
26 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
27 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28
Testosterone enanthate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 315-37-7 9416
29 Testosterone undecanoate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Vardenafil Dihydrochloride Phase 4
31 Vasodilator Agents Phase 4,Early Phase 1
32 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
33 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
35 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Hypoglycemic Agents Phase 4,Phase 3,Phase 1,Phase 2
38 insulin Phase 4,Phase 3,Phase 1,Phase 2
39 Insulin, Globin Zinc Phase 4,Phase 3,Phase 1,Phase 2
40 Micronutrients Phase 4,Phase 3,Phase 2
41 Mitogens Phase 4
42 Trace Elements Phase 4,Phase 3,Phase 2
43 Vitamins Phase 4,Phase 3,Phase 2
44 decanoic acid Phase 4
45 Contraceptive Agents Phase 4,Phase 3,Phase 2,Early Phase 1
46 Luteolytic Agents Phase 4
47 Triptorelin Pamoate Phase 4
48 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Fenugreek seed meal Phase 4

Interventional clinical trials:

(show top 50) (show all 339)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4 Pulsatile Gonadotropin Releasing Hormone;Human chorionic gonadotropin;Urinary Follicle-Stimulating Hormone
2 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
3 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4 Testosterone
4 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4 androgel;androgel 10g;placebo
5 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4 Oral testosterone undecanoate;Transdermal testosterone gel (AndroGel)
7 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
8 Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ Completed NCT02937740 Phase 4 NATESTO Testosterone Nasal Gel
9 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4 Testosterone enanthate (Sustanon 250 mg);Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU);Testosteron gel (Testojel 50 mg)
10 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4 Sustanon
11 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4 Testosterone 250mg injection;Testosteron 50 mg transdermal gel
12 Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment Completed NCT02111434 Phase 4 Testosterone
13 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4 Testosteron
14 Sequential Therapy for Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4 Traditional intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH plus zinc
15 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4 Testosterone
16 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4 Testogel 50 mg transdermal gel;Testosterone 250mg injection
17 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
18 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4 Testosteron 250mg injection;Testosterone 50mg transdermal application
19 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4 testosterone;placebo
20 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism Completed NCT02102646 Phase 4 Triptorelin
21 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4 AndroGel (testosterone gel) 1%
22 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
23 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4 Dutasteride;Testosterone gel;Placebo dutasteride
24 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
25 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
26 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4 Topical Testosterone Solution
27 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4 dutasteride;placebo
28 Effect of Testosterone Replacement on Insulin Resistance Completed NCT00487734 Phase 4 Placebo for testosterone gel
29 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
30 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
31 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4 Testosterone;0.9% saline
32 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
33 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
34 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4 Testosterone;Placebo
35 Aripiprazole and Prolactin Study Completed NCT01085383 Phase 4 Aripiprazole
36 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
37 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
38 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
39 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Recruiting NCT02880280 Phase 4 Human Menopausal Gonadotropin;Human Chorionic Gonadotropin
40 Vitamin D Treatment and Hypogonadism in Men Recruiting NCT01748370 Phase 4 Vitamin D supplementation in hypogonadal men;Vitamin D supplementation in eugonadal men;Placebo hypogonadal;Placebo eugonadal
41 Testosterone Therapy in Hypogonadal Men Treated With Opioids Recruiting NCT02433730 Phase 4 Testosterone;placebo
42 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Recruiting NCT02959853 Phase 4 Anastrazole
43 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
44 Subcutaneous vs. Intramuscular Testosterone Recruiting NCT03091348 Phase 4 Testosterone
45 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos
46 TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY Recruiting NCT03325647 Phase 4 Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution;Placebo injectable saline
47 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
48 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Active, not recruiting NCT02408445 Phase 4 testosterone cypionate 200mg/ml
49 NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) Terminated NCT01092858 Phase 4 Testosterone Undeconate (Nebido, BAY86-5037);Placebo
50 Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L]) Terminated NCT00328926 Phase 4 Luveris® 75 IU;Luveris® 25 IU;Placebo;Recombinant human follicle stimulating hormone (r-hFSH);Recombinant human chorionic gonadotropin (r-hCG)

Search NIH Clinical Center for Hypogonadism

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypogonadism

Genetic Tests for Hypogonadism

Genetic tests related to Hypogonadism:

# Genetic test Affiliating Genes
1 Hypogonadism 28

Anatomical Context for Hypogonadism

MalaCards organs/tissues related to Hypogonadism:

38
Bone, Prostate, Testes, Pituitary, Ovary, Endothelial, Brain

Publications for Hypogonadism

Articles related to Hypogonadism:

(show top 50) (show all 1194)
# Title Authors Year
1
Topical Testosterone Therapy Adherence and Outcomes Among Men With Primary or Secondary Hypogonadism. ( 29425664 )
2018
2
Myotonic dystrophy type 1 with diabetes mellitus, mixed hypogonadism and adrenal insufficiency. ( 29367875 )
2018
3
Rapid recovery of hypogonadism in male patients with end stage renal disease after renal transplantation. ( 29392618 )
2018
4
Primary adrenal insufficiency due to hereditary apolipoprotein AI amyloidosis: endocrine involvement beyond hypogonadism. ( 29446975 )
2018
5
GENETICS IN ENDOCRINOLOGY: Genetic counseling for congenital hypogonadotropic hypogonadism and Kallmann syndrome: new challenges in the era of oligogenism and next-generation sequencing. ( 29330225 )
2018
6
The effects of low-dose human chorionic gonadotropin combined with human menopausal gonadotropin protocol on women with hypogonadotropic hypogonadism undergoing ovarian stimulation for in vitro fertilization. ( 28960429 )
2018
7
Congenital Hypogonadotropic Hypogonadism and Constitutional Delay of Growth and Puberty Have Distinct Genetic Architectures. ( 29419413 )
2018
8
Benefit of routine testicular examination: hypogonadism in a person with 47XYY. ( 29415365 )
2018
9
Screening for Hypogonadism in Primary Healthcare: How to do this Effectively. ( 29365335 )
2018
10
Klinefelter syndrome: more than hypogonadism. ( 29382506 )
2018
11
FGFR1 disruption identified by whole genome sequencing in a male with a complex chromosomal rearrangement and hypogonadotropic hypogonadism. ( 29160040 )
2018
12
Hypogonadism in male thalassemia major patients: pathophysiology, diagnosis and treatment. ( 29451224 )
2018
13
Hypogonadism: Therapeutic Risks, Benefits, and Outcomes. ( 29406064 )
2018
14
Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy. ( 29396841 )
2018
15
Infertility treatment strategy involving combined freeze-all embryos and single vitrified-warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism. ( 29436143 )
2018
16
Health-related physical fitness and quality of life in men with congenital hypogonadotropic hypogonadism. ( 29430665 )
2018
17
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. ( 29311296 )
2018
18
DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development. ( 29202173 )
2018
19
Chronic cholestasis is associated with hypogonadism and premature ovarian failure in adult rats (cholestasis causes ovarian hypogonadism). ( 29297778 )
2018
20
The safety of available treatments of male hypogonadism in organic and functional hypogonadism. ( 29334271 )
2018
21
Long-Term Testosterone Therapy Improves Urinary and Sexual Function and Quality of Life in Men with Hypogonadism: Results from a Propensity Matched Subgroup of a Controlled Registry Study. ( 28728990 )
2017
22
Bone mineral density in older patients with never-treated congenital hypogonadotropic hypogonadism. ( 28577250 )
2017
23
GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism. ( 28611058 )
2017
24
CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism. ( 28324054 )
2017
25
An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome. ( 29056130 )
2017
26
Correction to: Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism. ( 29221463 )
2017
27
Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants. ( 29144511 )
2017
28
Psychometric Evaluation of the Hypogonadism Impact of Symptoms Questionnaire Short Form (HIS-Q-SF). ( 28760247 )
2017
29
Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. ( 28694969 )
2017
30
Is hypogonadism the cause of penile self-amputation in a patient with prior testes self-mutilation? ( 28885657 )
2017
31
Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). ( 28067604 )
2017
32
KLB, encoding I^-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. ( 28754744 )
2017
33
Hypogonadism in mitochondrial disorders. ( 28549633 )
2017
34
Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism. ( 28870428 )
2017
35
Clinical and genetic features of 64 young male paediatric patients with congenital hypogonadotropic hypogonadism. ( 28833369 )
2017
36
HIV and hypogonadism: a new challenge for young-aged and middle-aged men on effective antiretroviral therapy. ( 28081039 )
2017
37
A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. ( 28284037 )
2017
38
Approaches to male hypogonadism in primary care. ( 28085783 )
2017
39
Does Testosterone Replacement Therapy Promote an Augmented Risk of Thrombotic Events in Thalassemia Major Male Patients with Hypogonadism? ( 28670553 )
2017
40
Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism. ( 29137650 )
2017
41
Hypogonadotropic hypogonadism in a female patient with congenital arhinia. ( 27941181 )
2017
42
Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. ( 28931393 )
2017
43
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
44
Hypogonadism with Normal Serum Testosterone. ( 28751320 )
2017
45
SOX2 nonsense mutation in a patient clinically diagnosed with non-syndromic hypogonadotropic hypogonadism. ( 28659543 )
2017
46
Anti-MA1llerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH. ( 28324034 )
2017
47
A patient with van Maldergem syndrome with endocrine abnormalities, hypogonadotropic hypogonadism, and breast aplasia/hypoplasia. ( 29046692 )
2017
48
Long-Term Follow-Up of Primary Medical Versus Surgical Treatment of Prolactinomas in Men: Effects on Hyperprolactinemia, Hypogonadism, and Bone Health. ( 27773859 )
2017
49
Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male. ( 28583920 )
2017
50
Clinical Characteristics, Health Care Utilization and Costs Among Men with Primary or Secondary Hypogonadism in a US Commercially Insured Population. ( 27939338 )
2017

Variations for Hypogonadism

Expression for Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for Hypogonadism

Pathways related to Hypogonadism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 ANOS1 DUSP6 FGF17 FGF8 FGFR1 FSHB
2
Show member pathways
13.16 FSHB GNRH1 GNRHR KISS1 KISS1R LHB
3
Show member pathways
12.38 FGF17 FGF8 FGFR1 GNRH1 LHB
4
Show member pathways
12.27 ANOS1 FGF17 FGF8 FGFR1
5
Show member pathways
11.91 ANOS1 FGF17 FGF8 FGFR1
6
Show member pathways
11.53 FGF17 FGF8 FGFR1
7 11.13 FSHB LHB LHCGR
8 10.73 FGF17 FGF8 FGFR1 GNRH1 LHB
9 10.14 FSHB GNRH1 GNRHR LHB LHCGR

GO Terms for Hypogonadism

Cellular components related to Hypogonadism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 ANOS1 FGF17 FGF8 FGFR1 FSHB GNRH1

Biological processes related to Hypogonadism according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 FGF17 FGF8 FGFR1 FSHB PROK2
2 cell-cell signaling GO:0007267 9.92 FGF17 FSHB GNRH1 LHB
3 regulation of receptor activity GO:0010469 9.91 FGF17 FGF8 FSHB GNRH1 LHB
4 MAPK cascade GO:0000165 9.89 DUSP6 FGF17 FGF8 FGFR1
5 response to organic cyclic compound GO:0014070 9.81 DUSP6 FGF8 GNRH1
6 male gonad development GO:0008584 9.79 LHB LHCGR NR0B1
7 phosphatidylinositol phosphorylation GO:0046854 9.78 FGF17 FGF8 FGFR1
8 female pregnancy GO:0007565 9.76 FSHB GNRH1 TAC3
9 peptide hormone processing GO:0016486 9.63 FSHB LHB
10 male genitalia development GO:0030539 9.63 FGF8 LHCGR
11 inner ear morphogenesis GO:0042472 9.63 CHD7 FGF8 FGFR1
12 regulation of osteoclast differentiation GO:0045670 9.61 FSHB LHCGR
13 aorta morphogenesis GO:0035909 9.6 CHD7 FGF8
14 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.58 FGF17 FGF8 FGFR1
15 gonad development GO:0008406 9.57 FGF8 NR0B1
16 generation of neurons GO:0048699 9.56 FGF8 FGFR1
17 male sex determination GO:0030238 9.55 GNRH1 NR0B1
18 organ induction GO:0001759 9.54 FGF8 FGFR1
19 branching involved in salivary gland morphogenesis GO:0060445 9.52 FGF8 FGFR1
20 tachykinin receptor signaling pathway GO:0007217 9.49 TAC3 TACR3
21 cellular response to gonadotropin stimulus GO:0071371 9.48 LHCGR NSMF
22 neuropeptide signaling pathway GO:0007218 9.46 KISS1R PROK2 PROKR2 TAC3
23 hormone-mediated signaling pathway GO:0009755 9.43 FSHB LHB LHCGR
24 follicle-stimulating hormone signaling pathway GO:0042699 9.37 FSHB LHCGR
25 G-protein coupled receptor signaling pathway GO:0007186 9.36 FSHB GNRH1 GNRHR KISS1 KISS1R LHB
26 progesterone biosynthetic process GO:0006701 9.32 FSHB LHB
27 fibroblast growth factor receptor signaling pathway GO:0008543 9.26 ANOS1 FGF17 FGF8 FGFR1
28 signal transduction GO:0007165 10.09 FGF17 FSHB GNRH1 GNRHR KISS1R LHB

Molecular functions related to Hypogonadism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGF17 FGF8 FGFR1
2 hormone activity GO:0005179 9.43 FSHB GNRH1 LHB
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF17 FGF8 FGFR1
4 G-protein coupled peptide receptor activity GO:0008528 9.32 KISS1R LHCGR
5 protein-hormone receptor activity GO:0016500 8.96 GNRHR LHCGR
6 1-phosphatidylinositol-3-kinase activity GO:0016303 8.8 FGF17 FGF8 FGFR1

Sources for Hypogonadism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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