MCID: HYP080
MIFTS: 59

Hypogonadism malady

Endocrine diseases, Reproductive diseases categories

Summaries for Hypogonadism

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hypogonadism is a medical term which describes a diminished functional activity of the gonads ? the... more...

MalaCards: Hypogonadism is related to hypogonadotropism and kallmann syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Ovarian steroidogenesis and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs bromocriptine and chlorotrianisene and the compounds degarelix and acyline have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and prostate, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Hypogonadism

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Aliases & Descriptions:

hypogonadism 9 11 46 63


External Ids:

Disease Ontology9 DOID:1924
MeSH36 D007006
SNOMED-CT59 48130008
NCIt41 C9227

Related Diseases for Hypogonadism

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18GeneCards, 19GeneDecks
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Diseases in the Hypogonadism family:

Hypogonadism Lhb-Related

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 457)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism31.6KISS1R, GNRH1
2kallmann syndrome30.7LEP, GNRHR, GNRH1, NR0B1, KISS1R
3klinefelter's syndrome30.6KISS1R, GNRHR
4infertility30.6LHCGR, LEP, GNRHR, GNRH1
5hypogonadotropic hypogonadism 8 with or without anosmia30.5KISS1R
6short stature30.3NR0B1, GNRH1, LEP
7azoospermia30.2NR0B1, GNRH1, LHCGR
8hypopituitarism30.0LEP, GNRH1
9precocious puberty30.0LHCGR, LEP, GNRHR, GNRH1, NR0B1
10prolactinoma30.0GNRH1, GNRHR
11pseudohermaphroditism30.0LHCGR
12amenorrhea29.9GNRH1, LEP
13oligospermia29.7GNRHR, GNRH1
14acromegaly29.7GNRH1, LEP
15adenoma29.7LHCGR, GNRHR, GNRH1, NR0B1
16pituitary adenoma29.6LEP, GNRHR, GNRH1, NR0B1
17breast cancer29.5LHCGR, LEP, GNRHR, GNRH1, DUSP6, NR0B1
18obesity10.5
19prostatitis10.5
20ataxia10.4
21mental retardation10.4
22diabetes mellitus10.3
23cerebellar ataxia10.3
24cerebellar ataxia and hypogonadotropic hypogonadism10.3
25prader-willi syndrome10.3
26x-linked adrenal hypoplasia congenita10.3
27hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
28hypogonadotropic hypogonadism 9 with or without anosmia10.3
29hypogonadotropic hypogonadism 17 with or without anosmia10.3
30hypogonadotropic hypogonadism 2 with or without anosmia10.3
31hypothyroidism10.2
32dilated cardiomyopathy with hypergonadotropic hypogonadism10.2
33prostate cancer10.2
34isolated gonadotropin-releasing hormone deficiency10.2
35pol iii-related leukodystrophies10.2
36ichthyosis and male hypogonadism10.2
37mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.2
38hypogonadotropic hypogonadism 13 with or without anosmia10.2
39hypogonadotropic hypogonadism 15 with or without anosmia10.2
40hypogonadotropic hypogonadism 4 with or without anosmia10.2
41hypogonadotropic hypogonadism 18 with or without anosmia10.2
42hypogonadotropic hypogonadism 7 with or without anosmia10.2
43hypogonadotropic hypogonadism 11 with or without anosmia10.2
44hypogonadotropic hypogonadism 16 with or without anosmia10.2
45hypogonadotropic hypogonadism 20 with or without anosmia10.2
46hypogonadotropic hypogonadism 12 with or without anosmia10.2
47hypogonadotropic hypogonadism 6 with or without anosmia10.2
48hypogonadotropic hypogonadism 14 with or without anosmia10.2
49hypogonadotropic hypogonadism 10 with or without anosmia10.2
50hypogonadotropic hypogonadism 19 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Symptoms for Hypogonadism

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Genetic Tests for Hypogonadism

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Anatomical Context for Hypogonadism

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34MalaCards
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MalaCards organs/tissues related to Hypogonadism:

34
Testes, Bone, Prostate, Ovary, Pituitary, Endothelial, Liver, Testis, Thyroid, Eye, Heart, Breast, Lung, Adipocyte, Pineal, Hypothalamus, Olfactory bulb, Kidney, Brain, Skin, Uterus, T cells

Animal Models for Hypogonadism or affiliated genes

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38MGI
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Publications for Hypogonadism

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53PubMed
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Articles related to Hypogonadism:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Alterations of the FSH and LH receptor genes and evaluation of sperm ultrastructure in men with idiopathic hypergonadotropic hypogonadism. (23884663)
2013
2
Registry of Hypogonadism in Men (RHYME): design of a multi-national longitudinal, observational registry of exogenous testosterone use in hypogonadal men. (23373674)
2013
3
Hypogonadism and neurological diseases. (23292617)
2013
4
Optimal diagnostic measures and thresholds for hypogonadism in men with HIV/AIDS: comparison between 2 transdermal testosterone replacement therapy gels. (23816769)
2013
5
Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy. (23794541)
2013
6
Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback. (23188540)
2013
7
Pituitary iron and volume predict hypogonadism in transfusional iron overload. (22213195)
2012
8
Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities. (22120930)
2012
9
Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadism. (21868746)
2012
10
Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism. (22341266)
2012
11
Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. (21464116)
2011
12
Assessment of possible effects for testosterone replacement therapy in men with symptomatic late-onset hypogonadism. (21219383)
2011
13
Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism. (20712429)
2011
14
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
15
Hypogonadism predisposes males to the development of behavioural and neuroplastic depressive phenotypes. (21481538)
2011
16
Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)
2010
17
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
18
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (20382689)
2010
19
Hepatic failure-induced hypogonadism in a prostate cancer patient. (20688306)
2010
20
Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp. (19351723)
2009
21
Hypogonadism on admission to acute rehabilitation is correlated with lower functional status at admission and discharge. (19330595)
2009
22
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. (19535795)
2009
23
Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases. (19327165)
2009
24
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
25
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
26
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males. (19734692)
2009
27
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
28
The relationship between hypogonadism and erectile dysfunction. (18305486)
2008
29
Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men. (18703567)
2008
30
Bilateral male breast cancer with male potential hypogonadism. (17543123)
2007
31
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1. (17167799)
2007
32
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
33
The value of pituitary magnetic resonance imaging in men with hypogonadism. (12913700)
2003
34
Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. (12913736)
2003
35
Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: a longitudinal pharmacogenetic study. (12727953)
2003
36
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. (11994356)
2002
37
Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. (10456179)
1999
38
MEHMO (mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly, obesity), a novel syndrome: assignment of disease locus to xp21.1-p22.13. (9781023)
1998
39
Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome. (9762009)
1998
40
DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)
1997
41
The association of premature ejaculation and hypogonadotropic hypogonadism. (9292835)
1997
42
Defective growth hormone secretion and hypogonadism in the new syndrome of congenital hypoparathyroidism, growth failure and dysmorphic features. (10830039)
1996
43
Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene. (7677154)
1995
44
Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. (8733264)
1995
45
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (7990958)
1994
46
Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. (8426037)
1993
47
Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. (1906410)
1991
48
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980
49
The Rud syndrome: ichthyosis, hypogonadism, mental retardation. (5173271)
1971
50
HYPOGONADOTROPHIC HYPOGONADISM IN THE LAURENCE-MOON SYNDROME. (14112243)
1964

Variations for Hypogonadism

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Expression for genes affiliated with Hypogonadism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

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51PathCards, 31KEGG, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
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Pathways related to Hypogonadism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9LHB, LHCGR
2
Show member pathways
Peptide GPCRs39
9.6KISS1R, GNRHR, LHCGR
3
Show member pathways
9.6GNRHR, LHB, LHCGR
4
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.4GNRH1, GNRHR, LHB
5
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.3LHCGR, LHB, LEP
69.2GNRH1, GNRHR, LHB, LHCGR
7
Show member pathways
9.1GNRHR, GNRH1, KISS1R, TAC3
8
Show member pathways
8.0LHCGR, LHB, LEP, GNRHR, GNRH1, KISS1R
9
Show member pathways
7.5LHCGR, LHB, LEP, GNRHR, GNRH1, DUSP6

Compounds for genes affiliated with Hypogonadism

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46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1degarelix46 30 1212.2GNRH1, GNRHR
2acyline4610.2GNRHR, GNRH1
3histrelin46 3011.2GNRHR, GNRH1
4abarelix46 30 1212.2GNRHR, GNRH1
5antarelix46 3011.2GNRHR, GNRH1
6antide46 3011.1GNRHR, GNRH1
7ganirelix46 3011.1GNRHR, GNRH1
8d-trp6-lhrh4610.1GNRHR, GNRH1
9nafarelin46 62 30 1213.1GNRH1, GNRHR
10ptx14610.1GNRH1, GNRHR
11leuprolide46 62 30 1213.1GNRH1, GNRHR
12danazol46 25 1212.1GNRH1, GNRHR
13flutamide46 62 1212.1LHCGR, GNRH1
14goserelin46 30 1211.9LHCGR, GNRHR, GNRH1
15pkcs469.9GNRHR, GNRH1
16buserelin46 30 1211.9GNRH1, GNRHR, LHCGR
17leuprolide acetate469.9GNRH1, GNRHR, LHCGR
18bromocriptine46 30 1211.9GNRH1, GNRHR
19tibolone469.8GNRH1, LEP
20ribonucleic acid469.8LHCGR, GNRHR, GNRH1
21raloxifene46 52 30 1212.7GNRHR, GNRH1
22naloxone46 30 52 1212.6GNRH1, LEP
23capsaicin46 3010.6TAC3, LEP
24dihydrotestosterone46 30 25 1212.6LEP, GNRHR, GNRH1
25dehydroepiandrosterone sulfate469.5GNRH1, LEP
26tamoxifen46 52 30 1212.5GNRH1, GNRHR, LEP
27alanine469.4LHCGR, GNRHR, GNRH1, KISS1R
28cetrorelix46 30 1211.4GNRH1, GNRHR, LEP, LHCGR
29acth469.4LHCGR, LEP, GNRH1, NR0B1
30acetylcholine46 52 30 25 1213.3TAC3, GNRH1, LEP
31arginine469.3GNRH1, GNRHR, LEP, LHCGR
32glutamate469.2LHCGR, LEP, GNRHR, GNRH1
33progesterone46 30 62 25 1213.1LHCGR, LEP, GNRHR, GNRH1, NR0B1
34testosterone46 62 25 1212.0LHCGR, LEP, GNRHR, GNRH1, NR0B1
35estradiol46 25 1211.0LHCGR, LEP, GNRHR, GNRH1, TAC3
36steroid469.0NR0B1, GNRH1, GNRHR, LEP, LHCGR
37estrogen468.7LHCGR, LEP, GNRHR, GNRH1, NR0B1, TAC3
38cysteine468.6NR0B1, DUSP6, LEP, LHCGR
39gnrh468.1TAC3, LHCGR, LHB, LEP, GNRHR, GNRH1

GO Terms for genes affiliated with Hypogonadism

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17Gene Ontology
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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5TAC3, HFE2, GNRH1, LEP

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:0071869.6KISS1R, GNRHR, LHCGR
2male gonad developmentGO:0085849.4NR0B1, LHB, LHCGR
3female pregnancyGO:0075658.9TAC3, GNRH1, LEP

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.2GNRH1, LEP, LHB

Products for genes affiliated with Hypogonadism

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  • Antibodies
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Sources for Hypogonadism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet