MCID: HYP080
MIFTS: 58

Hypogonadism malady

Summaries for Hypogonadism

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Wikipedia:65 Hypogonadism is a medical term which describes a diminished functional activity of the gonads ? the... more...

MalaCards based summary: Hypogonadism is related to hypogonadotropism and kallmann syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Ovarian steroidogenesis and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds degarelix and acyline have been mentioned in the context of this disorder. Affiliated tissues include testes, prostate and bone, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Disease Ontology:10 A gonadal disease that is characterized by diminished functional activity of the gonads.

Aliases & Classifications for Hypogonadism

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Hypogonadism, Aliases & Descriptions:

Name: Hypogonadism 10 12 45 62


External Ids:

Disease Ontology10 DOID:1924
NCIt40 C9227
SNOMED-CT57 48130008
MeSH35 D007006

Related Diseases for Hypogonadism

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Diseases in the Hypogonadism family:

Hypogonadism Lhb-Related

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 471)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism31.6KISS1R, GNRH1
2kallmann syndrome30.9LEP, GNRHR, GNRH1, NR0B1, KISS1R
3infertility30.6LHCGR, LEP, GNRHR, GNRH1
4klinefelter's syndrome30.6KISS1R, GNRHR
5hypogonadotropic hypogonadism 8 with or without anosmia30.5KISS1R
6azoospermia30.1NR0B1, GNRH1, LHCGR
7prolactinoma30.1GNRH1, GNRHR
8precocious puberty30.1LHCGR, LEP, GNRHR, GNRH1, NR0B1
9hypopituitarism30.0LEP, GNRH1
10pseudohermaphroditism30.0LHCGR
11amenorrhea29.9GNRH1, LEP
12adenoma29.9LHCGR, GNRHR, GNRH1, NR0B1
13oligospermia29.7GNRHR, GNRH1
14addison's disease29.7GNRHR, NR0B1
15anovulation29.7GNRH1, LEP
16acromegaly29.7GNRH1, LEP
17pituitary adenoma29.6LEP, GNRHR, GNRH1, NR0B1
18breast cancer29.6LHCGR, LEP, GNRHR, GNRH1, DUSP6, NR0B1
19obesity10.5
20prostatitis10.5
21ataxia10.4
22mental retardation10.4
23cerebellar ataxia and hypogonadotropic hypogonadism10.4
24prader-willi syndrome10.3
25hypogonadotropic hypogonadism 2 with or without anosmia10.3
26malouf syndrome10.3
27cerebellar ataxia10.3
28prostate cancer10.3
29hypogonadotropic hypogonadism 9 with or without anosmia10.3
30hypogonadotropic hypogonadism 13 with or without anosmia10.3
31hypogonadotropic hypogonadism 11 with or without anosmia10.3
32hypogonadotropic hypogonadism 12 with or without anosmia10.3
33hypogonadotropic hypogonadism 10 with or without anosmia10.3
34hypogonadotropic hypogonadism 7 without anosmia10.3
35hypogonadotropic hypogonadism 1 with or without anosmia10.3
36x-linked adrenal hypoplasia congenita10.3
37hypogonadotropic hypogonadism 4 with or without anosmia10.3
38hypogonadotropic hypogonadism 16 with or without anosmia10.3
39hypogonadotropic hypogonadism 6 with or without anosmia10.3
40hypogonadotropic hypogonadism 3 with or without anosmia10.3
41hypothyroidism10.3
42hydrocephalus obesity hypogonadism10.3
43hypogonadotropic hypogonadism 15 with or without anosmia10.3
44hypogonadotropic hypogonadism 5 with or without anosmia10.3
45boucher-neuhauser syndrome10.3
46hypogonadotropic hypogonadism with or without anosmia10.3
47hypogonadotropic hypogonadism 21 with anosmia10.3
48isolated gonadotropin-releasing hormone deficiency10.3
49mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.3
50hypogonadotropic hypogonadism 18 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Symptoms for Hypogonadism

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Genetic Tests for Hypogonadism

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Anatomical Context for Hypogonadism

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MalaCards organs/tissues related to Hypogonadism:

33
Testes, Prostate, Bone, Ovary, Pituitary, Endothelial, Liver, Testis, Thyroid, Eye, Heart, Lung, Breast, Brain, Adipocyte, Kidney, Skin, Uterus, Olfactory bulb, Hypothalamus, Pineal, Neutrophil, T cells

Animal Models for Hypogonadism or affiliated genes

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Publications for Hypogonadism

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Articles related to Hypogonadism:

(show top 50)    (show all 1001)
idTitleAuthorsYear
1
Hypogonadism and fertility issues following primary treatment for testicular cancer. (25736189)
2015
2
On the mark? Is alkaline phosphatase a surrogate for bone density in men with hypogonadism? (25683880)
2015
3
Camurati-engelmann disease association with hypogonadism and primary hypothyroidism. (25389497)
2014
4
Hypogonadotropic hypogonadism in a female patient previously diagnosed as having waardenburg syndrome due to a sox10 mutation. (25273316)
2014
5
Alterations of the FSH and LH receptor genes and evaluation of sperm ultrastructure in men with idiopathic hypergonadotropic hypogonadism. (23884663)
2013
6
Insulinoma presenting with long-standing depression, primary hypogonadism, and sertoli cell only syndrome. (24455334)
2013
7
Registry of Hypogonadism in Men (RHYME): design of a multi-national longitudinal, observational registry of exogenous testosterone use in hypogonadal men. (23373674)
2013
8
Hypogonadism and neurological diseases. (23292617)
2013
9
Optimal diagnostic measures and thresholds for hypogonadism in men with HIV/AIDS: comparison between 2 transdermal testosterone replacement therapy gels. (23816769)
2013
10
Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy. (23794541)
2013
11
Pituitary iron and volume predict hypogonadism in transfusional iron overload. (22213195)
2012
12
Approach to the male patient with congenital hypogonadotropic hypogonadism. (22392951)
2012
13
Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities. (22120930)
2012
14
Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadism. (21868746)
2012
15
Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism. (22341266)
2012
16
Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. (21464116)
2011
17
Assessment of possible effects for testosterone replacement therapy in men with symptomatic late-onset hypogonadism. (21219383)
2011
18
Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism. (20712429)
2011
19
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
20
Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)
2010
21
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
22
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (20382689)
2010
23
Hepatic failure-induced hypogonadism in a prostate cancer patient. (20688306)
2010
24
Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp. (19351723)
2009
25
Hypogonadism on admission to acute rehabilitation is correlated with lower functional status at admission and discharge. (19330595)
2009
26
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. (19535795)
2009
27
Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases. (19327165)
2009
28
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
29
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
30
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males. (19734692)
2009
31
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
32
The relationship between hypogonadism and erectile dysfunction. (18305486)
2008
33
Bilateral male breast cancer with male potential hypogonadism. (17543123)
2007
34
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1. (17167799)
2007
35
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
36
The value of pituitary magnetic resonance imaging in men with hypogonadism. (12913700)
2003
37
Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. (12913736)
2003
38
Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: a longitudinal pharmacogenetic study. (12727953)
2003
39
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. (11994356)
2002
40
Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. (10456179)
1999
41
MEHMO (mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly, obesity), a novel syndrome: assignment of disease locus to xp21.1-p22.13. (9781023)
1998
42
Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome. (9762009)
1998
43
DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)
1997
44
Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene. (7677154)
1995
45
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (7990958)
1994
46
Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. (8426037)
1993
47
Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. (1906410)
1991
48
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980
49
The Rud syndrome: ichthyosis, hypogonadism, mental retardation. (5173271)
1971
50
HYPOGONADOTROPHIC HYPOGONADISM IN THE LAURENCE-MOON SYNDROME. (14112243)
1964

Variations for Hypogonadism

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Expression for genes affiliated with Hypogonadism

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Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

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Pathways related to Hypogonadism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9LHB, LHCGR
2
Show member pathways
Peptide GPCRs38
9.6KISS1R, GNRHR, LHCGR
3
Show member pathways
9.6GNRHR, LHB, LHCGR
4
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.4GNRH1, GNRHR, LHB
5
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.3LHCGR, LHB, LEP
69.2GNRH1, GNRHR, LHB, LHCGR
7
Show member pathways
9.1GNRHR, GNRH1, KISS1R, TAC3
8
Show member pathways
8.0LHCGR, LHB, LEP, GNRHR, GNRH1, KISS1R
9
Show member pathways
7.5LHCGR, LHB, LEP, GNRHR, GNRH1, DUSP6

Compounds for genes affiliated with Hypogonadism

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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1degarelix45 30 1312.2GNRH1, GNRHR
2acyline4510.2GNRHR, GNRH1
3histrelin45 3011.2GNRHR, GNRH1
4abarelix45 30 1312.2GNRHR, GNRH1
5antarelix45 3011.2GNRHR, GNRH1
6antide45 3011.1GNRHR, GNRH1
7ganirelix45 3011.1GNRHR, GNRH1
8d-trp6-lhrh4510.1GNRHR, GNRH1
9nafarelin45 61 30 1313.1GNRH1, GNRHR
10ptx14510.1GNRH1, GNRHR
11leuprolide45 61 30 1313.1GNRH1, GNRHR
12danazol45 26 1312.1GNRH1, GNRHR
13flutamide45 61 1312.1LHCGR, GNRH1
14goserelin45 30 1311.9LHCGR, GNRHR, GNRH1
15pkcs459.9GNRHR, GNRH1
16buserelin45 30 1311.9GNRH1, GNRHR, LHCGR
17leuprolide acetate459.9GNRH1, GNRHR, LHCGR
18bromocriptine45 30 1311.9GNRH1, GNRHR
19tibolone459.8GNRH1, LEP
20ribonucleic acid459.8LHCGR, GNRHR, GNRH1
21raloxifene45 51 30 1312.7GNRHR, GNRH1
22naloxone45 30 51 1312.6GNRH1, LEP
23capsaicin45 3010.6TAC3, LEP
24dihydrotestosterone45 30 26 1312.6LEP, GNRHR, GNRH1
25dehydroepiandrosterone sulfate459.5GNRH1, LEP
26tamoxifen45 51 30 1312.5GNRH1, GNRHR, LEP
27alanine459.4LHCGR, GNRHR, GNRH1, KISS1R
28cetrorelix45 30 1311.4GNRH1, GNRHR, LEP, LHCGR
29acth459.4LHCGR, LEP, GNRH1, NR0B1
30acetylcholine45 51 30 26 1313.3TAC3, GNRH1, LEP
31arginine459.3GNRH1, GNRHR, LEP, LHCGR
32glutamate459.2LHCGR, LEP, GNRHR, GNRH1
33progesterone45 30 61 26 1313.1LHCGR, LEP, GNRHR, GNRH1, NR0B1
34testosterone45 61 26 1312.0LHCGR, LEP, GNRHR, GNRH1, NR0B1
35estradiol45 26 1311.0LHCGR, LEP, GNRHR, GNRH1, TAC3
36steroid459.0NR0B1, GNRH1, GNRHR, LEP, LHCGR
37estrogen458.7LHCGR, LEP, GNRHR, GNRH1, NR0B1, TAC3
38cysteine458.6NR0B1, DUSP6, LEP, LHCGR
39gnrh458.1TAC3, LHCGR, LHB, LEP, GNRHR, GNRH1

GO Terms for genes affiliated with Hypogonadism

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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5TAC3, HFE2, GNRH1, LEP

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00071869.6KISS1R, GNRHR, LHCGR
2male gonad developmentGO:00085849.4NR0B1, LHB, LHCGR
3female pregnancyGO:00075658.9TAC3, GNRH1, LEP

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.2GNRH1, LEP, LHB

Products for genes affiliated with Hypogonadism

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Sources for Hypogonadism

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet