MCID: HYP080
MIFTS: 54

Hypogonadism malady

Summaries for Hypogonadism

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hypogonadism is a medical term which describes a diminished functional activity of the gonads – the... more...

MalaCards: Hypogonadism is related to kallmann syndrome and klinefelter's syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs bromocriptine and chlorotrianisene and the compounds gnrh and testosterone have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hypogonadism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

hypogonadism 8 10 45 61


External Ids:

Disease Ontology8 DOID:1924
MeSH35 D007006
SNOMED-CT57 48130008
NCIt40 C9227

Related Diseases for Hypogonadism

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 433)
idRelated DiseaseScoreTop Affiliating Genes
1kallmann syndrome30.8NSMF, GNRH1, GNRHR, KAL1, PROK2, NR0B1
2klinefelter's syndrome30.5NSMF, GNRHR, FGFR1, TAC3, KISS1R
3infertility30.5LHCGR, GNRH1, GNRHR, SHBG, LEP
4gynecomastia30.2SHBG, GNRH1
5short stature30.2GNRH1, SHBG, NR0B1, LEP
6insulin resistance30.1SHBG, LEP
7precocious puberty30.0LHCGR, GNRH1, GNRHR, SHBG, NR0B1, LEP
8azoospermia30.0NR0B1, SHBG, GNRH1, LHCGR
9turner syndrome29.9GNRH1
10prolactinoma29.9GNRHR, GNRH1
11growth hormone deficiency29.9LEP
12premature ovarian failure29.9SHBG, GNRH1
13adenoma29.8LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
14amenorrhea29.8LEP, SHBG, GNRH1
15adenocarcinoma29.8GNRHR, FGFR1
16cryptorchidism29.6FGFR1, SHBG, KAL1, GNRH1
17ovarian hyperstimulation syndrome29.6GNRH1
18renal agenesis29.6KAL1
19acromegaly29.6LEP, SHBG, GNRH1
20hypogonadism, hypergonadotropic10.5
21n syndrome10.4
22ataxia10.4
23mental retardation10.3
24prader-willi syndrome10.3
25cerebellar ataxia and hypogonadotropic hypogonadism10.3
26deafness hypogonadism syndrome10.2
27hypogonadotropic hypogonadism 9 with or without anosmia10.2
28hypogonadotropic hypogonadism 17 with or without anosmia10.2
29hypogonadotropic hypogonadism 2 with or without anosmia10.2
30hypogonadotropic hypogonadism 8 with or without anosmia10.2
31hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.2
32dilated cardiomyopathy with hypergonadotropic hypogonadism10.2
33isolated gonadotropin-releasing hormone deficiency10.2
34pol iii-related leukodystrophies10.2
35ichthyosis and male hypogonadism10.2
36mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.2
37hypogonadotropic hypogonadism 13 with or without anosmia10.2
38hypogonadotropic hypogonadism 15 with or without anosmia10.2
39hypogonadotropic hypogonadism 4 with or without anosmia10.2
40hypogonadotropic hypogonadism 18 with or without anosmia10.2
41hypogonadotropic hypogonadism 7 with or without anosmia10.2
42hypogonadotropic hypogonadism 11 with or without anosmia10.2
43hypogonadotropic hypogonadism 16 with or without anosmia10.2
44hypogonadotropic hypogonadism 20 with or without anosmia10.2
45hypogonadotropic hypogonadism 12 with or without anosmia10.2
46hypogonadotropic hypogonadism 6 with or without anosmia10.2
47hypogonadotropic hypogonadism 14 with or without anosmia10.2
48hypogonadotropic hypogonadism 10 with or without anosmia10.2
49hypogonadotropic hypogonadism 19 with or without anosmia10.2
50hypogonadotropic hypogonadism 3 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Clinical Features for Hypogonadism

Genetic Tests for Hypogonadism

Anatomical Context for Hypogonadism

Animal Models for Hypogonadism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypogonadism

Sources:
51PubMed
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Articles related to Hypogonadism:

(show top 50)    (show all 882)
idTitleAuthorsYear
1
Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and II_BI^ and attenuated by argirein and valsartan. (23665494)
2013
2
Selective androgen receptor modulators for the treatment of late onset male hypogonadism. (24407183)
2013
3
Testosterone replacement therapy can increase circulating endothelial progenitor cell number in men with late onset hypogonadism. (23653307)
2013
4
Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated. Cardiological disorders. (24167528)
2013
5
Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges. (23640935)
2013
6
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. (23643382)
2013
7
A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as reversal of hypogonadotropic hypogonadism and late-onset hypogonadism. (22788855)
2013
8
A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain. (23326276)
2012
9
Hypogonadism among HIV-infected men in Thailand. (23258828)
2012
10
Hypogonadism related to crizotinib therapy: implications for patient care. (22487894)
2012
11
How to recognize late-onset hypogonadism in men with sexual dysfunction. (22286862)
2012
12
A closed literature-based discovery technique finds a mechanistic link between hypogonadism and diminished sleep quality in aging men. (22294819)
2012
13
The direct and indirect costs among U.S. privately insured employees with hypogonadism. (22738380)
2012
14
Assessment of possible effects for testosterone replacement therapy in men with symptomatic late-onset hypogonadism. (21219383)
2011
15
Andrology: Is there a link between hypogonadism and vitamin D deficiency in aging men? (22276295)
2011
16
Penile growth in response to human chorionic gonadotropin (HCG) treatment in patients with idiopathic hypogonadotrophic hypogonadism. (22111055)
2011
17
Elevated serum receptor activator of nuclear factor kappa B ligand and osteoprotegerin levels in late-onset male hypogonadism. (21810381)
2011
18
Late-onset hypogonadism. (21549875)
2011
19
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (20382689)
2010
20
Male hypogonadism: Symptoms and treatment. (22247861)
2010
21
Outcome of gonadotropin therapy for male infertility due to hypogonadotrophic hypogonadism. (19838805)
2010
22
Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome. (20938417)
2010
23
Kallmann Syndrome and hypogonadotropic hypogonadism. Preface. (20806808)
2010
24
Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. (20628262)
2010
25
An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement. (19143734)
2009
26
X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene. (19773398)
2009
27
An unusual cause of adult onset cerebellar ataxia with hypogonadism. (20151008)
2009
28
Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism? A comparison between idiopathic and secondary hypogonadotrophic hypogonadism. (19824804)
2009
29
Low Testosterone in Older Men: A Discussion and Review of Literature on Health Consequences of Hypogonadism in the Aging Male. (23965325)
2009
30
Reversible hypogonadism in Bardet-Biedl syndrome. (19327768)
2009
31
Hypogonadism and erectile dysfunction: an overview. (18087642)
2008
32
Gynecomastia and hypogonadism. (18057157)
2008
33
Symptomatic evaluation of late onset hypogonadism in healthy Chinese men]. (17491264)
2007
34
Masking of central diabetes insipidus and hypogonadotrophic hypogonadism by germ cell tumour in suprasellar--pineal region. (17623967)
2006
35
Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. (15811136)
2005
36
Sex steroids and sexual desire in a man with a novel mutation of aromatase gene and hypogonadism. (15721053)
2005
37
Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. (15970005)
2005
38
Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH). (15362570)
2004
39
Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. (12913736)
2003
40
Aromatase inhibition for the treatment of idiopathic hypogonadotropic hypogonadism in men with premature ejaculation. (12938779)
2003
41
Study of autoimmunity in Klinefelter's syndrome and idiopathic hypogonadotropic hypogonadism. (12078855)
2002
42
Hypogonadotrophic hypogonadism in Roifman syndrome. (10905663)
2000
43
Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)
1999
44
New mutations of DAX-1 genes in two Japanese patients with X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. (8636263)
1996
45
A new family of Boucher-NeuhAouser syndrome: coexistence of Holmes type cerebellar atrophy, hypogonadotropic hypogonadism and retinochoroidal degeneration: case reports and review of literature. (7670566)
1995
46
Testosterone normalizes plasma vasopressin response to osmotic stimuli in men with hypogonadism. (7920892)
1993
47
The comparative characteristics of parlodel, zinc sulfate and recombinant erythropoietin in treating uremic hypogonadism in patients on chronic hemodialysis]. (1293848)
1992
48
Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. (1743335)
1991
49
Male hypogonadism and bone fracture. (3352692)
1988
50
Ocular coloboma and hypothalamic hypogonadism. Case report. (3632408)
1987

Genetic Variations for Hypogonadism

Expression for genes affiliated with Hypogonadism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Hypogonadism

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1gnrh4511.5KISS1, LHB, LHCGR, NSMF, GNRH1, GNRHR
2testosterone45 60 11 2414.3LHCGR, NSMF, GNRH1, GNRHR, SHBG, NR0B1
3steroid4511.3LHCGR, GNRH1, GNRHR, KAL1, SHBG, NR0B1
4progesterone45 60 29 11 2415.2LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
5estradiol45 11 2413.2LHCGR, GNRH1, GNRHR, SHBG, TAC3, LEP
6acth4511.1LEP, NR0B1, SHBG, GNRH1, LHCGR
7cetrorelix45 29 1113.1LHCGR, GNRH1, GNRHR, LEP
8goserelin45 29 1113.1LHCGR, GNRH1, GNRHR, SHBG
9leuprolide acetate4511.1LHCGR, GNRH1, GNRHR, SHBG
10alanine4511.0LHCGR, GNRH1, GNRHR, SHBG, KISS1R, KISS1
11buserelin45 29 1113.0LHCGR, GNRH1, GNRHR
12dihydrotestosterone45 29 11 2414.0GNRH1, GNRHR, SHBG, LEP
13tibolone4511.0LEP, SHBG, GNRH1
14danazol45 11 2413.0GNRH1, GNRHR, SHBG
15flutamide45 60 1113.0LHCGR, GNRH1, SHBG
16dopamine45 29 11 2414.0TAC3, FGFR1, SHBG, GNRHR, GNRH1
17degarelix45 29 1112.9GNRHR, GNRH1
18estrogen4510.9TAC3
19histrelin29 4511.9GNRH1, GNRHR
20abarelix45 29 1112.9GNRH1, GNRHR
21bromocriptine29 45 1112.9GNRH1, GNRHR, SHBG
22antarelix45 2911.9GNRH1, GNRHR
23adenylate4510.9LHCGR, GNRH1, GNRHR, SHBG, FGFR1
24acyline4510.9GNRH1, GNRHR
25dehydroepiandrosterone sulfate4510.9LEP, SHBG, GNRH1
26antide45 2911.9GNRHR, GNRH1
27raloxifene45 29 50 1113.9GNRH1, GNRHR, SHBG
28ganirelix45 2911.9GNRHR, GNRH1
29d-trp6-lhrh4510.9GNRHR, GNRH1
30metformin45 50 1112.9GNRH1, SHBG, LEP
31ribonucleic acid4510.9FGFR1, GNRHR, GNRH1, LHCGR
32nafarelin45 60 29 1113.8GNRHR, GNRH1
33tamoxifen45 50 29 1113.8LEP, SHBG, GNRHR, GNRH1
34androstenedione45 2411.8GNRH1, SHBG, LEP
35ptx14510.7GNRHR, GNRH1
36progestin4510.7SHBG, GNRH1, LHCGR
37leuprolide45 60 29 1113.6GNRH1, GNRHR
38megestrol acetate4510.6LEP, SHBG
39allopregnanolone4510.5SHBG, GNRH1
40estrone45 29 11 2413.3LEP, SHBG, GNRH1

GO Terms for genes affiliated with Hypogonadism

Sources:
16Gene Ontology
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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7KISS1, LEP, TAC3, HFE2, KAL1, GNRH1
2extracellular regionGO:00557610.5KISS1, LHB, GNRH1, PROK2, SHBG, FGFR1

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPK cascadeGO:04341010.8KISS1, LEP, FGFR1
2positive regulation of luteinizing hormone secretionGO:03368610.7KISS1, LEP
3male gonad developmentGO:00858410.7LHB, LHCGR, NR0B1
4female pregnancyGO:00756510.7LEP, TAC3, GNRH1
5G-protein coupled receptor signaling pathwayGO:00718610.7KISS1R, PROK2, GNRHR, LHCGR
6cellular response to gonadotropin stimulusGO:07137110.6LHCGR, NSMF
7positive regulation of synaptic transmissionGO:05080610.5KISS1R, KISS1
8neuropeptide signaling pathwayGO:00721810.3KISS1R, TAC3, PROK2

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6LEP, GNRH1, LHB

Products for genes affiliated with Hypogonadism

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Sources for Hypogonadism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet