MCID: HYP080
MIFTS: 60

Hypogonadism malady

Summaries for Hypogonadism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypogonadism is a medical term which describes a diminished functional activity of the gonads – the... more...

MalaCards: Hypogonadism is related to hypogonadotropism and kallmann syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs bromocriptine and chlorotrianisene and the compounds gnrh and testosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and prostate, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hypogonadism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

hypogonadism 8 10 44 60


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Disease Ontology8 DOID:1924
MeSH34 D007006
SNOMED-CT56 48130008
NCIt39 C9227

Related Diseases for Hypogonadism

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17GeneCards, 18GeneDecks
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Diseases in the Hypogonadism family:

Hypogonadism Lhb-Related

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism31.4KISS1R, GNRH1
2kallmann syndrome30.7NSMF, GNRH1, GNRHR, KAL1, PROK2, NR0B1
3obesity30.7PHF6, SHBG, NR0B1, FGFR1, LEP
4infertility30.5LHCGR, GNRH1, GNRHR, SHBG, LEP
5klinefelter's syndrome30.4NSMF, GNRHR, FGFR1, TAC3, KISS1R
6prostate cancer30.3GNRH1, GNRHR, SHBG, NR0B1, FGFR1, KISS1
7hypothyroidism30.3LEP, SHBG
8gynecomastia30.2SHBG, GNRH1
9male infertility30.1GNRH1, SHBG
10azoospermia30.0NR0B1, SHBG, GNRH1, LHCGR
11gonadal dysgenesis30.0NR0B1
12hypopituitarism29.9LEP, SHBG, GNRH1
13prolactinoma29.9GNRHR, GNRH1
14impotence29.9SHBG
15premature ovarian failure29.9SHBG, GNRH1
16adenoma29.8LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
17amenorrhea29.8LEP, SHBG, GNRH1
18pseudohermaphroditism29.8LHCGR
19adenocarcinoma29.8GNRHR, FGFR1
20pituitary adenoma29.6GNRH1, GNRHR, NR0B1, LEP
21cryptorchidism29.6FGFR1, SHBG, KAL1, GNRH1
22pre-eclampsia29.6KISS1, LEP, TAC3, SHBG
23ovarian hyperstimulation syndrome29.6GNRH1
24breast cancer29.6GNRH1, GNRHR, SHBG, FGFR1, KISS1
25turner syndrome29.6GNRH1
26hypertension29.6LEP
27renal agenesis29.6KAL1
28acromegaly29.6LEP, SHBG, GNRH1
29ovarian disease29.6SHBG, GNRH1
30prostatitis10.4
31diabetes mellitus10.3
32cerebellar ataxia10.2
33cerebellar ataxia and hypogonadotropic hypogonadism10.2
34prader-willi syndrome10.2
35hypogonadotropic hypogonadism 9 with or without anosmia10.2
36hypogonadotropic hypogonadism 17 with or without anosmia10.2
37hypogonadotropic hypogonadism 2 with or without anosmia10.2
38hypogonadotropic hypogonadism 8 with or without anosmia10.2
39hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.2
40dilated cardiomyopathy with hypergonadotropic hypogonadism10.2
41isolated gonadotropin-releasing hormone deficiency10.2
42pol iii-related leukodystrophies10.2
43ichthyosis and male hypogonadism10.2
44mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.2
45hypogonadotropic hypogonadism 13 with or without anosmia10.2
46hypogonadotropic hypogonadism 15 with or without anosmia10.2
47hypogonadotropic hypogonadism 4 with or without anosmia10.2
48hypogonadotropic hypogonadism 18 with or without anosmia10.2
49hypogonadotropic hypogonadism 7 with or without anosmia10.2
50hypogonadotropic hypogonadism 11 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Clinical Features for Hypogonadism

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Drugs & Therapeutics for Hypogonadism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypogonadism

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Anatomical Context for Hypogonadism

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32MalaCards
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MalaCards organs/tissues related to Hypogonadism:

32
Testes, Bone, Prostate, Ovary, Pituitary, Endothelial, Liver, Testis, Thyroid, Eye, Heart, Breast, Lung, Adipocyte, Pineal, Hypothalamus, Olfactory bulb, Kidney, Brain, Skin, Uterus, T cells

Animal Models for Hypogonadism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypogonadism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537911.0KISS1, LHB, LHCGR, GNRH1, GNRHR, NR0B1
2MP:000536710.8LHCGR, GNRH1, GNRHR, HFE2, FGFR1, LEP
3MP:001077110.8GNRHR, HFE2, FGFR1, KISS1R, KISS1, ALX4
4MP:000538110.7LHCGR, GNRH1, GNRHR, FGFR1, LEP, KISS1R
5MP:000538910.6LHB, LHCGR, GNRH1, GNRHR, NR0B1, HFE2

Publications for Hypogonadism

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50PubMed
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Articles related to Hypogonadism:

(show top 50)    (show all 955)
idTitleAuthorsYear
1
Effects of 5-year treatment with testosterone undecanoate on lower urinary tract symptoms in obese men with hypogonadism and metabolic syndrome. (24139347)
2014
2
Hypogonadism, testosterone, and nursing home residents. (23647780)
2013
3
Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty. (24118936)
2013
4
Assessment of deoxyribonucleic acid fragmentation index, testicular volume, semen parameters, and hormone profile in gonadotropin-treated men with hypogonadotropic hypogonadism. (24094652)
2013
5
Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges. (23640935)
2013
6
Effects of pharmacologically induced hypogonadism on mood and behavior in healthy young women. (23545794)
2013
7
Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). (22419720)
2012
8
Late onset hypogonadism in males - think of it - act on it. (22257034)
2012
9
Late-onset hypogonadism: an undertreated condition in aging Lebanese men. (23461089)
2012
10
Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population. (23106878)
2012
11
A novel DAX1/NR0B1 mutation in a patient with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (23295288)
2012
12
Emerging medication for the treatment of male hypogonadism. (22612692)
2012
13
Molecular defects of the GnRH-receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism. (23155690)
2012
14
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4. (21791561)
2011
15
Use of hormone replacement therapy for correction of high turnover bone disease in hypogonadal I^-Thalassemia major patients presenting with osteoporosis: comparison with idiopathic premature ovarian failure. (22074125)
2011
16
Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. (21543378)
2011
17
Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism. (21627562)
2011
18
Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility. (22035015)
2011
19
Re: treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: effects on body composition, lipids, and psychosexual complaints. (22088646)
2011
20
Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. (20382682)
2010
21
Adult-onset hypogonadotropic hypogonadism caused by aberrant expression of aromatase in an adrenocortical adenocarcinoma. (20467160)
2010
22
Complex genetics in idiopathic hypogonadotropic hypogonadism. (20389092)
2010
23
Anti-mA1llerian hormone and sertoli cell function in paediatric male hypogonadism. (20190544)
2010
24
Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases. (19327165)
2009
25
Epidemiology, diagnosis, and treatment of male hypogonadotropic hypogonadism. (19955846)
2009
26
Bone mineral density in human immunodeficiency virus-1 infected men with hypogonadism prior to highly-active-antiretroviral-therapy (HAART). (19258214)
2009
27
Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre. (19337172)
2008
28
Correlation between simultaneous PSA and serum testosterone concentrations among eugonadal, untreated hypogonadal and hypogonadal men receiving testosterone replacement therapy. (18843272)
2008
29
Bilateral male breast cancer with male potential hypogonadism. (17543123)
2007
30
Increased human chorionic gonadotropin due to hypogonadism after treatment of a testicular seminoma. (17644799)
2007
31
The latest options and future agents for treating male hypogonadism. (18001258)
2007
32
Congenital toxoplasmosis presenting as hypogonadotropic hypogonadism. (17595502)
2007
33
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. (15240592)
2004
34
Thyrotoxicosis presenting as hypogonadism: a case of central hyperthyroidism. (15545848)
2004
35
Pharmacokinetics and tolerability of a bioadhesive buccal testosterone tablet in hypogonadal men. (14713280)
2004
36
Evidence for tissue selectivity of the synthetic androgen 7 alpha-methyl-19-nortestosterone in hypogonadal men. (12788888)
2003
37
Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. (11422108)
2001
38
Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. (9425890)
1998
39
Clinical evaluation in isolated hypogonadotrophic hypogonadism (Kallmann syndrome). (9829214)
1998
40
The association of premature ejaculation and hypogonadotropic hypogonadism. (9292835)
1997
41
Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. (9253326)
1997
42
Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility. (9010147)
1997
43
EEC syndrome with diabetes insipidus and hypogonadism. (8194569)
1994
44
Male hypogonadism with gynecomastia caused by late-onset deficiency of testicular 17-ketosteroid reductase. (8469252)
1993
45
Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. (1727547)
1992
46
Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. (1743335)
1991
47
Hypergonadotropic hypogonadism in female patients with galactosemia. (6782485)
1981
48
Micropenis. III. Primary hypogonadism, partial androgen insensitivity syndrome, and idiopathic disorders. (7441936)
1980
49
Klinefelter's syndrome with hypogonadotrophic hypogonadism. (832081)
1977
50
An autopsy case of stunted growth with fatty liver cirrhosis, hepatoma, hypogonadism, osteoporosis and lipid pneumonia. (4302027)
1968

Genetic Variations for Hypogonadism

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Expression for genes affiliated with Hypogonadism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Hypogonadism

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1gnrh4411.5KISS1, LHB, LHCGR, NSMF, GNRH1, GNRHR
2testosterone44 59 11 2414.3LHCGR, NSMF, GNRH1, GNRHR, SHBG, NR0B1
3steroid4411.3LHCGR, GNRH1, GNRHR, KAL1, SHBG, NR0B1
4progesterone44 59 28 11 2415.2LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
5estradiol44 11 2413.2LHCGR, GNRH1, GNRHR, SHBG, TAC3, LEP
6acth4411.1LEP, NR0B1, SHBG, GNRH1, LHCGR
7cetrorelix44 28 1113.1LHCGR, GNRH1, GNRHR, LEP
8goserelin44 28 1113.1LHCGR, GNRH1, GNRHR, SHBG
9leuprolide acetate4411.1LHCGR, GNRH1, GNRHR, SHBG
10alanine4411.0LHCGR, GNRH1, GNRHR, SHBG, KISS1R, KISS1
11buserelin44 28 1113.0LHCGR, GNRH1, GNRHR
12dihydrotestosterone44 28 11 2414.0GNRH1, GNRHR, SHBG, LEP
13tibolone4411.0LEP, SHBG, GNRH1
14danazol44 11 2413.0GNRH1, GNRHR, SHBG
15flutamide44 59 1113.0LHCGR, GNRH1, SHBG
16dopamine44 28 11 2414.0TAC3, FGFR1, SHBG, GNRHR, GNRH1
17degarelix44 28 1112.9GNRHR, GNRH1
18estrogen4410.9TAC3
19histrelin28 4411.9GNRH1, GNRHR
20abarelix44 28 1112.9GNRH1, GNRHR
21bromocriptine28 44 1112.9GNRH1, GNRHR, SHBG
22antarelix44 2811.9GNRH1, GNRHR
23adenylate4410.9LHCGR, GNRH1, GNRHR, SHBG, FGFR1
24acyline4410.9GNRH1, GNRHR
25dehydroepiandrosterone sulfate4410.9LEP, SHBG, GNRH1
26antide44 2811.9GNRHR, GNRH1
27raloxifene44 28 49 1113.9GNRH1, GNRHR, SHBG
28ganirelix44 2811.9GNRHR, GNRH1
29d-trp6-lhrh4410.9GNRHR, GNRH1
30metformin44 49 1112.9GNRH1, SHBG, LEP
31ribonucleic acid4410.9FGFR1, GNRHR, GNRH1, LHCGR
32nafarelin44 59 28 1113.8GNRHR, GNRH1
33tamoxifen44 49 28 1113.8LEP, SHBG, GNRHR, GNRH1
34androstenedione44 2411.8GNRH1, SHBG, LEP
35ptx14410.7GNRHR, GNRH1
36progestin4410.7SHBG, GNRH1, LHCGR
37leuprolide44 59 28 1113.6GNRH1, GNRHR
38megestrol acetate4410.6LEP, SHBG
39allopregnanolone4410.5SHBG, GNRH1
40estrone44 28 11 2413.3LEP, SHBG, GNRH1

GO Terms for genes affiliated with Hypogonadism

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16Gene Ontology
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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7KISS1, LEP, TAC3, HFE2, KAL1, GNRH1
2extracellular regionGO:00557610.5KISS1, LHB, GNRH1, PROK2, SHBG, FGFR1

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPK cascadeGO:04341010.8KISS1, LEP, FGFR1
2positive regulation of luteinizing hormone secretionGO:03368610.7KISS1, LEP
3male gonad developmentGO:00858410.7LHB, LHCGR, NR0B1
4female pregnancyGO:00756510.7LEP, TAC3, GNRH1
5G-protein coupled receptor signaling pathwayGO:00718610.7KISS1R, PROK2, GNRHR, LHCGR
6cellular response to gonadotropin stimulusGO:07137110.6LHCGR, NSMF
7positive regulation of synaptic transmissionGO:05080610.5KISS1R, KISS1
8neuropeptide signaling pathwayGO:00721810.3KISS1R, TAC3, PROK2

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6LEP, GNRH1, LHB

Products for genes affiliated with Hypogonadism

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Sources for Hypogonadism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet