Hypogonadism malady

Wikipedia: Hypogonadism is a medical term which describes a diminished functional activity of the gonads – the...⁴⁴ more...

MalaCards: Hypogonadism, also known as hypogonadism (disorder), is related to hypogonadotropism and kallmann syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are G alpha (q) signalling events and Neuroactive ligand-receptor interaction. The drugs estropipate and polyestradiol and the compounds gnrh and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and ovary, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Descriptions:

hypogonadism 6 7 8 32 43 hypogonadism (disorder) 6

Diseases related to hypogonadism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 930)

id	Related Disease	Score	Top Affiliating Genes
1	hypogonadotropism	35.8	WDR11, NDN, KISS1, KISS1R, PCSK1, RBM28
2	kallmann syndrome	34.4	KISS1, KISS1R, PCSK1, LHX3, LEP, LEPR
3	adrenal hypoplasia	33.9	GNRH1, GK, ESRRB, CYP11A1, NR0B1, NR5A1
4	klinefelter's syndrome	32.7	KISS1R, CHD7, FGFR1, GNRHR, TAC3, TACR3
5	delayed puberty	32.7	KISS1, KISS1R, LHCGR, LEP, CGA, CGB5
6	x-linked adrenal hypoplasia congenita	32.6	GK, ESRRB, NR0B1, NR5A1, STAR
7	hypogonadism, hypergonadotropic	32.3	FSHR, CYP19A1, WT1, SHBG, PRL
8	gonadotropin deficiency	31.7	KISS1R, CGA, KAL1, FSHR, FGFR1, GNRH1
9	hemochromatosis	31.1	FXN, HFE, HFE2, TF, HAMP
10	morbid obesity	30.2	RETN, LEP, LEPR, INS, GHRL, LSL
11	bardet-biedl syndrome	30.1	PARK2, LEP, LEPR, BBS1, BBS2, CGA
12	anosmia	29.9	CHD7, XG, KAL1, FGF8, FGFR1, GNRHR
13	prolactinoma	29.6	PBX1, BGLAP, CGA, INS, IGFBP3, IGF1
14	premature ovarian failure	29.4	LGR6, FSHR, INHA, IGFBP3, GNRH1, CYP11A1
15	leptin deficiency	29.4	LEP, LEPR, GH1, LSL
16	male infertility	29.3	USP26, CGA, FSHR, AR, GNRH1, ESR2
17	prader-willi syndrome	28.9	NDN, RETN, LEP, LEPR, INS, MAGEL2
18	cerebellar ataxia	28.9	ATXN2, FXN, INS, GHRH, NDUFS4, TF
19	microcephaly	28.8	RBM28, RAB3GAP1, RAB3GAP2, RAB18, ATRX, MEHMO
20	familial male-limited precocious puberty	28.8	KISS1, LHCGR, LEP, CGA, CGB5, FSHR
21	gynecomastia	28.2	RBM28, BRD2, LEP, CGA, CGB5, AR
22	aromatase deficiency	28.1	BGLAP, INS, GNRH1, GH1, CYP19A1
23	amenorrhea	28.1	BRD2, BGLAP, LHB, LHCGR, LGR6, LEP
24	borjeson-forssman-lehmann syndrome	28.1	LHX3, DLG3, PHF6, HESX1, PROP1, POU1F1
25	cerebellar hypoplasia	28.0	RECQL4, LMNA, LHCGR, LHX3, LGR6, CHD7
26	gonadal dysgenesis	28.0	BRD2, BGLAP, CGB5, ATRX, FSHR, AMH
27	turner syndrome	28.0	BGLAP, CGA, IGFBP1, IGFBP3, IGF1, GH1
28	premature ejaculation	28.0	PDE4A, LEP, CYP19A1, PDE5A, LSL, PRL
29	martsolf syndrome	27.8	RAB3GAP1, RAB3GAP2, GNRH1
30	synostosis	27.8	RECQL4, FGFR1, IHH, ALX4, NOG
31	encephalomyopathy	27.7	GH1, GHRH, NDUFS4, TYMP, POLG, POLG2
32	hypothyroidism	27.5	CGA, FSHR, CALCA, TRH, SHBG, THRB
33	pituitary tumor	27.5	PCSK1, PBX1, LEPR, FSHB, FSHR, IGF1
34	acanthosis nigricans	27.5	LMNA, LEP, INS, INSR, IGF1, ALMS1
35	swyer syndrome	27.3	F8, SRY, PRL
36	mental retardation syndrome	27.3	PARK2, ATRX, AR, GK, DLG3, NR0B1
37	tremor	27.3	PARK2, ATXN2, APOA1, CUL4B, GFAP, POLG
38	ataxia	27.1	SERPINE1, SCN4A, LEPR, ATXN2, KAL1, FXN
39	azoospermia	27.1	BRD2, USP26, PBX1, LHCGR, CGA, CGB5
40	craniopharyngioma	27.0	BRD2, LEP, CGA, INS, IL6, IGF1
41	beta thalassemia	27.0	HFE, TF, EPO
42	x-linked ichthyosis	26.9	XG, KAL1, SULT2A1, STS
43	testicular cancer	26.7	SERPINE1, CGA, CGB5, FSHR, AR, IL6
44	myotonic dystrophy	26.6	LMNA, CLCN1, SCN4A, LEP, AR, INS
45	anophthalmia	26.6	INS, SRY, HESX1, PRL, POU1F1
46	alopecia universalis	26.6	WDR11, INS, TNF, POMC
47	glucose intolerance	26.3	RETN, SERPINE1, LIPC, LEP, LEPR, INS
48	alopecia	26.3	RBM28, VDR, LMNA, FOXN1, AR, INS
49	muscular dystrophy	25.8	LMNA, CLCN1, PARK2, SCN4A, AR, INS
50	liver cirrhosis	25.4	RETN, SERPINC1, LEPR, INSR, IGFBP3, ALB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 black cohosh, black cohosh extract, bromocriptine, bromocriptine mesylate, chlorotrianisene, estradiol, estradiol 17-beta, estradiol acetate, estradiol cypionate, estradiol pwdr [va product], estradiol valerate, estrogens, estrogens,conjugated, estrogens,conjugated synthetic a, estrogens,conjugated synthetic b, estrogens,esterified, estrone, estrone sodium sulfate, estropipate, ethinyl estradiol, ethynodiol diacetate, fluoxymesterone, methyltestosterone, methyltestosterone pwdr [va product], norethindrone, norethindrone acetate, polyestradiol, polyestradiol phosphate, testosterone, testosterone cypionate, testosterone enanthate, testosterone propionate, testosterone propionate pwdr [va product], testosterone pwdr [va product]

MalaCards organs/tissues related to hypogonadism:

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MGI Mouse Phenotypes related to hypogonadism:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	KISS1, KISS1R, PCSK1, BRD2, LHB, LHCGR
2	integument phenotype	MP:0010771	10.6	NDN, RECQL4, KISS1, KISS1R, CLCN1, PBX1
3	hematopoietic system phenotype	MP:0005397	10.5	PIK3AP1, RECQL4, KISS1R, PCSK1, CHD7, FTH1
4	respiratory system phenotype	MP:0005388	10.1	NDN, PARK2, LEPR, CHD7, BBS1, INSR
5	craniofacial phenotype	MP:0005382	9.6	RECQL4, PBX1, LHX3, CHD7, BBS1, INHBB
6	taste/olfaction phenotype	MP:0005394	9.6	PDE4A, BBS1, BBS2, MAGEL2, TERT, NOG
7	renal/urinary system phenotype	MP:0005367	9.5	KISS1, KISS1R, SERPINA6, LMNA, CLU, PBX1
8	embryogenesis phenotype	MP:0005380	9.5	RECQL4, SERPINC1, BRD2, PBX1, CHD7, ATRX
9	limbs/digits/tail phenotype	MP:0005371	9.5	RECQL4, VDR, LMNA, PBX1, LEP, CHD7
10	other phenotype	MP:0005395	9.4	CLU, PBX1, LEPR, FSHR, ESR2, CRH
11	hearing/vestibular/ear phenotype	MP:0005377	9.3	VDR, LMNA, CLCN1, PBX1, LHX3, CHD7
12	normal phenotype	MP:0002873	8.1	NDN, KISS1R, LMNA, PBX1, LGR6, LEPR
13	skeleton phenotype	MP:0005390	8.0	GC, VDR, LMNA, CLCN1, PBX1, PARK2
14	liver/biliary system phenotype	MP:0005370	7.8	RETN, SERPINC1, SERPINA6, BRD2, PBX1, BBS2
15	tumorigenesis	MP:0002006	7.5	RECQL4, SERPINE1, LEP, LEPR, FSHR, FOXN1
16	adipose tissue phenotype	MP:0005375	7.3	RETN, PCSK1, SERPINE1, BRD2, LMNA, LHCGR
17	vision/eye phenotype	MP:0005391	7.3	RECQL4, SERPINC1, LMNA, CLCN1, LEP, LEPR
18	nervous system phenotype	MP:0003631	7.3	NDN, PDE4A, KISS1, KISS1R, SERPINC1, BRD2
19	behavior/neurological phenotype	MP:0005386	7.1	NDN, KISS1R, PCSK1, SERPINA6, BRD2, LMNA
20	digestive/alimentary phenotype	MP:0005381	6.0	RECQL4, KISS1, KISS1R, PCSK1, VDR, LMNA
21	cellular phenotype	MP:0005384	INF	PIK3AP1, NDN, RECQL4, PCSK1, BRD2, VDR
22	reproductive system phenotype	MP:0005389	INF	KISS1, KISS1R, PCSK1, VDR, LMNA, LIPC
23	mortality/aging	MP:0010768	INF	NDN, RECQL4, KISS1, KISS1R, PCSK1, SERPINC1
24	cardiovascular system phenotype	MP:0005385	INF	PDE4A, PCSK1, SERPINC1, SERPINE1, VDR, LMNA
25	muscle phenotype	MP:0005369	INF	NDN, PCSK1, LMNA, CLCN1, CLU, PARK2
26	no phenotypic analysis	MP:0003012	INF	NDN, SERPINA6, RAB18, CLCN1, LEPR, FXN
27	homeostasis/metabolism phenotype	MP:0005376	INF	NDN, RETN, KISS1, KISS1R, PCSK1, GC
28	immune system phenotype	MP:0005387	INF	PIK3AP1, PDE4A, RECQL4, KISS1R, PCSK1, SERPINA6
29	growth/size phenotype	MP:0005378	INF	RECQL4, KISS1, KISS1R, PCSK1, SERPINE1, BRD2

Articles related to hypogonadism:

(show top 50)    (show all 355)

id	Title	Authors	Year	Affiliating Genes
1	Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)	Bouligand J.... Young J.	2010	GNRH1
2	Improvement of the metabolic syndrome and of non-alco holic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate. (19472103)	Haider A.... Saad F.	2010	CRP
3	Improvement of the diabetic foot upon testosterone ad ministration to hypogonadal men with peripheral arterial disease. Report of thr ee cases. (19327165)	Kalinchenko S.... Gooren L.J.	2009	SERPINC1
4	Effects of FSH on testicular mRNA transcript levels i n the hypogonadal mouse. (19136570)	Abel M.H.... O'Shaughnessy P.J.	2009	CGA
5	Novel relationships of age, visceral adiposity, insul in-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men durin g experimental hypogonadal clamp. (19351723)	Veldhuis J.D.... Bowers C.Y.	2009	GHRH
6	GNRH1 mutations in patients with idiopathic hypogonad otropic hypogonadism. (19567835)	Chan Y.M.... Seminara S.B.	2009	GNRH1
7	X-linked congenital adrenal hypoplasia with hypogonad otropic hypogonadism caused by an inversion disrupting a conserved noncoding el ement upstream of the NR0B1 (DAX1) gene. (19773398)	Skinningsrud B.... Undlien D.E.	2009	NR0B1
8	Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism? A comparison between idiopathic a nd secondary hypogonadotrophic hypogonadism. (19824804)	Resorlu B.... Aydos K.	2009	CGA
9	Role of gonadotropin-releasing hormone and human chor ionic gonadotropin stimulation tests in differentiating patients with hypogonad otropic hypogonadism from those with constitutional delay of growth and puberty . (19017752)	Segal T.Y.... Dattani M.T.	2009	CGB5
10	Preservation of GHRH and GH-releasing peptide-2 effic acy in young men with experimentally induced hypogonadism. (19458139)	Veldhuis J.D.... Bowers C.Y.	2009	IGF1, IGFBP3, IGFBP1
11	Hypogonadotrophic hypogonadism in type 2 diabetes, ob esity and the metabolic syndrome. (19075678)	Dandona P.... Mohanty P.	2008	CRP, INS
12	C-reactive protein levels and ageing male symptoms in hypogonadal men treated with testosterone supplementation. (19032692)	Giltay E.J.... Gooren L.J.	2008	CRP
13	Nanomilled oral testosterone plus dutasteride effecti vely normalizes serum testosterone in normal men with induced hypogonadism. (18077826)	Page S.T.... Amory J.K.	2008	SRD5A1
14	The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men. (18343420)	Rhoden E.L.... Morgentaler A.	2008	KLK3
15	Correlation between simultaneous PSA and serum testosterone concentrations among eugonadal, untreated hypogonadal and hypogonadal men receiving testosterone replacement therapy. (18843272)	Grober E.D.... Lipshultz L.I.	2008	KLK3
16	Blood coagulation and fibrinolysis in male patients with hypogonadotropic hypogonadism: plasma factor V and factor X activities increase in hypogonadotropic hypogonadism. (18591887)	Erem C.... Yilmaz M.	2008	PLAT, F10, F8
17	Cognitive dysfunction and hypogonadotrophic hypogonadism in a Brazilian patient with mitochondrial neurogastrointestinal encephalomyopathy and a novel ECGF1 mutation. (17437622)	Carod-Artal F.J.... Montoya J.	2007	TYMP
18	KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans. (17213338)	Bhagavath B.... Layman L.C.	2007	KAL1
19	Symptomatic evaluation of late onset hypogonadism in healthy Chinese men (17491264)	Li J.Y.... Meng P.	2007	LEP
20	Prostate-specific antigen testing in hypogonadism: implications for the safety of testosterone-replacement therapy. (16831134)	Gould D.C.... Kirby R.S.	2006	KLK3
21	Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. (15598687)	Semple R.K.... Aparicio S.A.	2005	KISS1R, KISS1
22	Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. (15602022)	Valdes-Socin H.... Beckers A.	2004	LHB
23	Testosterone replacement therapy in male hypogonadism. (12906378)	Byrne M.... Nieschlag E.	2003	KLK3
24	The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty. (12824862)	Degros V.... Dewailly D.	2003	CGB5
25	Hypogonadism and diabetes. (12934046)	Betancourt-Albrecht M.... Cunningham G.R.	2003	SHBG
26	Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita. (11788621)	Mantovani G.... Beck-Peccoz P.	2002	NR0B1
27	Genetics of hypogonadotropic hypogonadism. (11079449)	Seminara S.B.... Crowley W.F.	2000	PCSK1, GNRHR
28	Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)	Achermann J.C.... Jameson J.L.	1999	NR0B1, KAL1
29	7Alpha-methyl-19-nortestosterone maintains sexual beh avior and mood in hypogonadal men. (10522995)	Anderson R.A.... Baird D.T.	1999	SRD5A1
30	Novel DAX1 mutations in X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. (10341858)	Bassett J.H.D.... Thakker R.V.	1999	NR0B1
31	Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene. (10522996)	Caron P.... Rochiccioli P.	1999	NR0B1
32	MEHMO (mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly, obesity), a novel syndrome: assignment of disease locus to xp21.1-p22.13. (9781023)	Steinmuller R.... Muller U.	1998	MEHMO
33	Novel mutation of the DAX1 gene in a patient with X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9508067)	Hamaguchi K.... Sakata T.	1998	NR0B1
34	Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. (9758439)	BA1chter D.... Nieschlag E.	1998	CGA, GNRH1
35	Cerebellar ataxia, hypogonadism and chorioretinopathy: molecular analysis of an Italian family. (10935859)	Rizzi R.... Montagna P.	1998	FXN
36	Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover. (9024272)	Guo C.Y.... Eastell R.	1997	CD36, CGA
37	Subcutaneous self-administration of highly purified follicle stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Spanish Collaborative Group on Male Hypogonadotropic Hypogonadism. (9194651)	BurguAcs S.... CalderA^n M.D.	1997	CGA
38	Hypogonadism and methadone: Hypothalamic hypogonadism after long-term use of high-dose methadone. (15251556)	de la Rosa R.E.... Hennessey J.V.	1996	PRL, GNRH1
39	Male hypogonadism in myotonic dystrophy is related to (CTG)n triplet mutation. (8077624)	Mastrogiacomo I.... Dallapiccola B.	1994	DMPK
40	Gene deletion causing adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. (8033374)	Matfin G.... Wass J.A.	1994	GK
41	Endogenous opioids and hypogonadism in human obesity. (7922600)	Blank D.M.... Blank M.S.	1994	GNRH1
42	Familial insulin resistant diabetes associated with acanthosis nigricans, polycystic ovaries, hypogonadism, pigmentary retinopathy, labyrinthine deafness, and mental retardation. (8456839)	Boor R.... SchAPnberger W.	1993	INSR, INS
43	Pulsatile GnRH treatment in boys and girls with idiopathic hypogonadotrophic hypogonadism. (8276956)	Delemarre-van de Waal H.A.... Odink R.J.	1993	GNRH1
44	Computer assisted sperm motility analysis at the moment of induced pregnancy during gonadotropin treatment for hypogonadotropic hypogonadism. (8282963)	Lenzi A.... Dondero F.	1993	CGA
45	Excessive L-thyroxine therapy decreases femoral bone mineral densities in the male rat: effect of hypogonadism and calcitonin. (1456090)	Ongphiphadhanakul B.... Baran D.T.	1992	CALCA
46	The comparative characteristics of parlodel, zinc su lfate and recombinant erythropoietin in treating uremic hypogonadism in patient s on chronic hemodialysis (1293848)	Kukhtevich A.V.... Smirnova G.A.	1992	EPO
47	Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. (1727547)	Weiss J.... Jameson J.L.	1992	LHB
48	Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)	Yasutomo Y.... Nagata N.	1991	INS
49	LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. (2181393)	Haavisto A.M.... Huhtaniemi I.	1990	GNRH1
50	A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance. (1251844)	Edwards J.A.... Frohman L.A.	1976	PIK3AP1

Genes related to hypogonadism according to GeneCards:

(show top 50)    (show all 166)

id	Symbol	Description	Score	GeneCards Section Context
1	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.1	Publications, Summaries, Aliases & Descriptions
2	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.1	Publications, Summaries
3	LEP	leptin	11.1	Summaries, Publications
4	LHB	luteinizing hormone beta polypeptide	11.0	Summaries, Publications
5	KISS1R	KISS1 receptor	11.0	Publications, Summaries
6	GNRHR	gonadotropin-releasing hormone receptor	11.0	Summaries, Publications
7	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Summaries, Publications
8	SLC29A3	solute carrier family 29 (nucleoside transporters), member 3	11.0	Summaries
9	NELF	nasal embryonic LHRH factor	11.0	Summaries, Publications
10	TAC3	tachykinin 3	11.0	Summaries, Publications
11	MEHMO	mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly and obesity syndrome	11.0	Aliases & Descriptions, Publications
12	HFE2	hemochromatosis type 2 (juvenile)	11.0	Summaries
13	PHF6	PHD finger protein 6	11.0	Summaries
14	ALX4	ALX homeobox 4	11.0	Summaries
15	SHBG	sex hormone-binding globulin	11.0	Publications
16	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
17	KLK3	kallikrein-related peptidase 3	11.0	Publications
18	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
19	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
20	PRL	prolactin	11.0	Publications
21	FSHR	follicle stimulating hormone receptor	11.0	Publications
22	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
23	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications, UniProt Related
24	PROK2	prokineticin 2	11.0	Publications
25	PROP1	PROP paired-like homeobox 1	11.0	Publications
26	DCAF17	DDB1 and CUL4 associated factor 17	11.0	Publications
27	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
28	KISS1	KiSS-1 metastasis-suppressor	11.0	Publications
29	GK	glycerol kinase	11.0	Publications
30	PCSK1	proprotein convertase subtilisin/kexin type 1	11.0	Publications
31	HAMP	hepcidin antimicrobial peptide	11.0
32	DMPK	dystrophia myotonica-protein kinase	11.0	Publications
33	POU1F1	POU class 1 homeobox 1	11.0
34	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
35	TACR3	tachykinin receptor 3	11.0	Publications
36	RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	11.0
37	POLG	polymerase (DNA directed), gamma	11.0
38	LSL	Leptin, serum levels of	11.0	Publications
39	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
40	PDE5A	phosphodiesterase 5A, cGMP-specific	11.0	Publications
41	CHD7	chromodomain helicase DNA binding protein 7	11.0	Publications
42	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	11.0	Publications
43	LEPR	leptin receptor	11.0	Publications
44	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0
45	HFE	hemochromatosis	11.0	Publications
46	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
47	AR	androgen receptor	11.0	Publications
48	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
49	GH1	growth hormone 1	11.0	Publications
50	CRH	corticotropin releasing hormone	11.0	Publications

Pathways related to hypogonadism according to GeneDecks:

(show all 43)

id	Pathway	Score	Top Affiliating Genes
1	G alpha (q) signalling events38	11.1	TAC3, TACR3, PROK2, PROKR2, TRH, GHRL
2	Neuroactive ligand-receptor interaction20	11.1	GNRHR, GH1, THRB, TACR3, PRL, NPY1R
3	Development_Role of Activin A in cell differentiation and proliferation41	10.8	PBX1, LHB, LHCGR, LHX3, CGA, FSHB
4	Development Role of Activin A in cell differentiation and proliferation10	10.8	STAR, VDR, PBX1, LHB, LHCGR, LHX3
5	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.7	TRH, LEPR
6	Adipocytokines & Insulin Signaling37	10.6	ADIPOQ, SLC2A4, INSR, INS, LEP, RETN
7	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.5	POMC, CRP, TRH, LEPR, LEP
8	Telomerase Components in Cell Signaling36	10.4	TERT, GHRH, GH1, GNRH1, IGF1, FGFR1
9	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.3	PTH, TNFSF11, IHH, BGLAP, VDR
10	Mitochondrial Apoptosis36	10.2	SLC25A4, GHRH, GH1, GNRH1, IGF1, IL6
11	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.1	PTH, TNFSF11, IHH, BGLAP, VDR
12	eIF2 Pathway36	10.1	GHRH, GH1, GNRH1, IGF1, IL6, FGFR1
13	p70S6K Signaling36	10.0	GHRH, GH1, GNRH1, IGF1, IL6, FGFR1
14	14-3-3 Induced Intracellular Signaling36	10.0	TNF, GHRH, GH1, GNRH1, IGF1, FGF8
15	eNOS Signaling36	10.0	NOS3, GHRH, GH1, ESR2, GNRH1, FGFR1
16	Adipocytokine signaling pathway20	10.0	ADIPOQ, SLC2A4, POMC, TNF, CD36, LEPR
17	Apoptotic Pathways in Synovial Fibroblasts36	9.8	TNF, GHRH, GH1, GNRH1, IGF1, IL6
18	Cellular Apoptosis Pathway36	9.8	SLC25A4, TNF, GHRH, GH1, GNRH1, IGF1
19	Selected targets of C/EBPalpha10	9.7	ADIPOQ, TF, ALB, CD36, SERPINC1, RETN
20	mTOR Pathway36	9.6	GHRH, GH1, GNRH1, IGF1, IL6, FGF8
21	Akt Signaling36	9.5	SLC2A4, TNFSF11, TNF, CCL3, IL6, FGFR1
22	Estrogen Pathway36	9.5	ESR2, GH1, GHRH, NR0B1, NOS3, GNRH1
23	Selected targets of HNF110	9.4	CRP, ALB, F8, IGFBP1, APOA1, INS
24	PPAR Pathway36	9.4	GH1, IGF1, IL6, FGFR1, FGF8, LHB
25	DHA Signaling36	9.4	GHRH, GH1, GNRH1, IGF1, IL6, IL1B
26	Activation of PKA through GPCR36	9.4	GH1, GHRH, CRP, NOS3, DHH, GNRH1
27	Blood Coagulation Signaling Pathways37	9.4	PLAT, F10, F5, F8, SERPINE1, SERPINC1
28	TGF-Beta Pathway36	9.1	GHRH, GH1, GNRH1, IGF1, CCL3, IL6
29	Complement and coagulation cascades20	9.1	PLAT, F10, F5, F8, SERPINE1, SERPINC1
30	JAK-STAT Pathway36	9.1	GNRH1, GH1, GHRH, PRL, EPO, IGF1
31	NF-KappaB (p50-p65) Pathway36	9.0	TNF, GHRH, GH1, GNRH1, IGF1, IL6
32	NF-KappaB Family Pathway36	9.0	TNF, GHRH, GH1, GNRH1, IGF1, IL6
33	Selected targets of GCR-alpha10	8.9	IL6, IGFBP1, TNFSF11, THRB, IL1B, INSR
34	LDL Oxidation in Atherogenesis36	8.9	TNF, CCL3, IL1B, CD36
35	PAK Pathway36	8.7	GNRH1, GH1, GHRH, TNF, TNFSF11, IGF1
36	Cytokine-cytokine receptor interaction20	8.6	EPO, PRL, TNFSF11, TNF, GH1, AMH
37	Tec Kinases Signaling36	8.5	TNF, GHRH, GH1, GNRH1, IGF1, CCL3
38	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.5	VDR, THRB, CYP19A1, PTH, TNFSF11, TNF
39	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.5	TNF, TNFSF11, PTH, CYP19A1, THRB, CALCA
40	Antioxidant Action of Vitamin-C36	8.4	GH1, GHRH, TNF, TNFSF11, SLC2A4, GNRH1
41	Rho Family GTPases36	8.3	GNRH1, GH1, GHRH, TNF, TNFSF11, GFAP
42	p38 Signaling36	7.9	GNRH1, GH1, GHRH, TNF, TNFSF11, IGF1
43	G alpha (s) signalling events38	INF	POMC, PDE4A, LHB, CGA, FSHB,

Compounds related to hypogonadism according to GeneDecks:

(show top 50)    (show all 434)

id	Compound	Score	Top Affiliating Genes
1	gnrh32	10.7	KISS1R, PCSK1, SERPINE1, PBX1, LHB, LHCGR
2	dehydroepiandrosterone sulfate32	10.6	SERPINA6, LEP, CGA, CGB5, AR, INS
3	c-peptide32	10.5	RETN, PCSK1, LEP, INSR, GHRL, SHBG
4	17-hydroxyprogesterone32 18	11.5	RETN, SERPINA6, PBX1, CGA, CGB5, IGFBP1
5	glucose32	10.5	PDE4A, KISS1, PCSK1, PARK2, FXN, FGFR1
6	bromocriptine32 9 9	12.4	GNRH1, GNRHR, GH1, GHRH, TRH, SST
7	clomiphene citrate32	10.4	CGA, CGB5, FSHB, INS, IGFBP1, IGFBP3
8	triiodothyronine32	10.3	SERPINA6, LIPC, LEP, LEPR, CGA, IGFBP1
9	clonidine32 9 9	12.2	BGLAP, LEP, CGA, IGFBP3, IGF1, CALCA
10	epinephrine32 9 18 9	13.2	PDE4A, LEP, CGA, CGB5, INS, INSR
11	androstenedione32 18	11.2	SERPINA6, PBX1, LEP, LEPR, CGA, CGB5
12	buserelin32 9 9	12.1	LHCGR, CGA, CGB5, FSHB, IGFBP1, IGFBP3
13	pioglitazone32 9 9	12.0	RETN, LIPC, LEP, INS, INSR, APOA1
14	cyproteroneacetate32	10.0	SERPINA6, SERPINE1, BGLAP, AR, INS, APOA1
15	dhea32	10.0	RETN, SERPINA6, LEP, CGB5, AR, INS
16	hexarelin32	10.0	PBX1, IGFBP3, IGF1, GH1, GHRH, GHRL
17	progestins32	10.0	SERPINA6, LIPC, AR, IGFBP1, IGFBP3, IGFBP4
18	octreotide32 42 9 9	12.9	INS, INSR, IGFBP1, IGFBP3, IGF1, GNRH1
19	pge232	9.9	PDE4A, LHCGR, CGA, CGB5, FSHR, AR
20	3beta-hydroxysteroid32	9.8	CLU, LHCGR, CGA, CGB5, AR, INHA
21	corticosterone32 18	10.8	SERPINA6, BGLAP, LHCGR, LEPR, CGB5, IL1B
22	dihydrotestosterone32 9 18 9	12.7	SERPINA6, SERPINE1, VDR, CLU, BGLAP, LEP
23	h2o232	9.7	PDE4A, RECQL4, CLU, BGLAP, PARK2, LEP
24	dopamine32 9 18 9	12.5	PDE4A, CLU, PARK2, LEPR, CGA, CGB5
25	estrone32 9 18 9	12.4	SERPINA6, BGLAP, LEP, CGB5, AR, IGFBP1
26	ascorbic acid32 18	10.3	VDR, BGLAP, CGA, CGB5, FTH1, CD36
27	progesterone32 42 9 18 9	13.1	PDE4A, KISS1, PCSK1, SERPINA6, CLU, PBX1
28	heparin32 9 18 9	11.8	SERPINE1, LIPC, BGLAP, CGA, KAL1, CD36
29	acth32	8.7	PCSK1, SERPINA6, PBX1, LHCGR, LEP, LEPR
30	creatinine32	8.7	RETN, GC, SERPINC1, VDR, LMNA, LEP
31	chloramphenicol32 9 9	10.2	GC, SERPINC1, SERPINE1, VDR, AR, INSR
32	raloxifene32 9 9	10.2	SERPINC1, SERPINE1, VDR, BGLAP, CD36, APOA1
33	cysteine32	8.0	SERPINA6, VDR, CLU, BGLAP, LHX3, LEPR
34	tamoxifen32 34 9 9	11.0	PDE4A, SERPINC1, SERPINA6, VDR, CLU, BGLAP
35	calcium32 9 18 9	10.5	PDE4A, RETN, KISS1, KISS1R, PCSK1, LMNA
36	alanine32	7.2	RETN, KISS1, KISS1R, SERPINC1, SERPINA6, VDR
37	thymidine32 18	8.2	VDR, CLU, LEPR, FSHR, FOLH1, INSR
38	vitamin d32	7.1	GC, SERPINE1, VDR, CLU, BGLAP, LEPR
39	lactate32	7.0	CLU, CGA, CGB5, INS, FGFR1, IL6
40	testosterone32 9 18 9	9.8	KISS1, GC, SERPINC1, SERPINA6, VDR, LIPC
41	prostacyclin32	6.6	PDE4A, SERPINC1, SERPINE1, LEP, CGA, INSR
42	cholesterol32 9 18 9	9.6	RETN, GC, SERPINA6, SERPINE1, LMNA, LIPC
43	indomethacin32 9 9	8.5	PDE4A, LEP, CGA, CGB5, IL1B, IL6
44	sb 20358032 42	7.2	SERPINE1, VDR, BGLAP, CD36, INSR, FGFR1
45	lipid32	5.9	PDE4A, RETN, PCSK1, GC, SERPINA6, SERPINE1
46	estrogen32	5.2	RETN, KISS1, PCSK1, GC, SERPINC1, SERPINA6
47	retinoic acid32 42 18	6.2	NDN, PDE4A, GC, SERPINE1, VDR, LMNA
48	vegf32	3.9	PDE4A, RETN, SERPINC1, SERPINE1, CLU, BGLAP
49	isoproterenol32 9 9	INF	PDE4A, LHCGR, CGB5, AR, INSR, GNRH1
50	forskolin32 42 9 9	INF	PDE4A, RETN, PCSK1, LHCGR, CGA, CGB5

Cellular components related to hypogonadism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	perinuclear region of cytoplasm	GO:048471	9.6	TF, HFE, NOS1, SRD5A1, INHBB, ATXN2
2	secretory granule	GO:030141	9.1	POMC, TF, PLAT, TRH, GHRL, APOA1
3	platelet alpha granule lumen	GO:031093	8.7	ALB, F5, F8, IGF1, CLU, SERPINE1
4	extracellular region	GO:005576	5.5	PROK2, PRL, POMC, ADIPOQ, HAMP, EPO
5	extracellular space	GO:005615	5.2	LEP, KAL1, INS, FGF8, IL1B, IL6

Biological processes related to hypogonadism according to GeneDecks:

(show top 50)    (show all 61)

id	Name	GO ID	Score	Top Affiliating Genes
1	male gonad development	GO:008584	11.1	SRD5A1, NR0B1, NR5A1, WT1, CYP19A1, INHA
2	peptide hormone processing	GO:016486	11.0	POMC, FSHB, CGA, LHB, PCSK1
3	gonad development	GO:008406	11.0	WT1, NR0B1, FGF8, FSHR, CGA
4	female pregnancy	GO:007565	10.9	PRL, STS, TAC3, HFE, CRH, GNRH1
5	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.9	GHRH, GH1, IGF1, IGFBP4, IGFBP3, AR
6	pituitary gland development	GO:021983	10.8	PCSK1, LHX3, SRD5A1, NR0B1, NOG
7	adrenal gland development	GO:030325	10.8	WT1, CRH, NR5A1, NR0B1, CYP19A1, APOA1
8	regulation of steroid biosynthetic process	GO:050810	10.8	DHH, NR5A1, LEP
9	hypothalamus development	GO:021854	10.8	NR0B1, SRD5A1, CYP19A1, RAB3GAP1
10	bone development	GO:060348	10.7	SRD5A1, CYP19A1, FGF8, BGLAP
11	skeletal system development	GO:001501	10.7	SHOX, NOG, PTH, ALX4, IGF1, IGFBP4
12	male sex determination	GO:030238	10.7	DHH, NR0B1, SRY, INSR
13	response to testosterone stimulus	GO:033574	10.6	EPO, PDE5A, CYP19A1, INSR, BGLAP
14	positive regulation of glucose import	GO:046326	10.6	INS, INSR, IGF1, PTH, ADIPOQ
15	negative regulation of multicellular organism growth	GO:040015	10.5	ALMS1, FXN, ATXN2, BBS2
16	positive regulation of glycogen biosynthetic process	GO:045725	10.5	PTH, IGF1, INSR, INS
17	cellular iron ion homeostasis	GO:006879	10.5	HAMP, TF, HFE, FTL, FTH1, FXN
18	induction of apoptosis by hormones	GO:008628	10.3	CRH, SST, PTH
19	G-protein coupled receptor signaling pathway	GO:007186	10.3	PROK2, SST, PTH, GHRL, GNRHR, APOA1
20	cholesterol metabolic process	GO:008203	10.2	STAR, CYP11A1, APOA1, LEPR, LEP, LIPC
21	response to morphine	GO:043278	10.1	TACR3, TAC3, CYP19A1, IL1B, PCSK1
22	response to estrogen stimulus	GO:043627	10.1	EPO, STS, CYP11A1, GHRL, BGLAP, SERPINE1
23	steroid metabolic process	GO:008202	10.1	STAR, SRD5A1, CYP19A1, CYP11A1, SULT2A1, GC
24	negative regulation of hydrolase activity	GO:051346	10.1	NOS3, NOS1, APOA1, LEPR
25	response to ethanol	GO:045471	10.1	ADIPOQ, SLC2A4, NOS3, TRH, GNRH1, INSR
26	positive regulation of vasodilation	GO:045909	10.0	NOS3, NOS1, CALCA, INS
27	glucose homeostasis	GO:042593	10.0	ADIPOQ, SLC2A4, ALMS1, INSR, INS, SERPINE1
28	positive regulation of MAP kinase activity	GO:043406	9.9	FGFR1, GH1, TNF, TNFSF11, PDE5A
29	monocyte chemotaxis	GO:002548	9.9	TNFSF11, CALCA, CCL3, IL6
30	positive regulation of cell proliferation	GO:008284	9.9	FGFR1, IL6, IGF1, GHRH, STS, EPO
31	positive regulation of MAPK cascade	GO:043410	9.8	IL6, IGFBP3, IGFBP4, IGF1, FGFR1, INSR
32	positive regulation of protein kinase B signaling cascade	GO:051897	9.8	TNFSF11, TNF, F10, IGF1, CCL3, INSR
33	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	ADIPOQ, GH1, IGF1, IL6, INS, CD36
34	response to drug	GO:042493	9.4	NOS3, SRD5A1, SST, CYP19A1, CYP11A1, TNF
35	positive regulation of mitosis	GO:045840	9.4	TNF, IGF1, IL1B, FGF8, INSR, INS
36	aging	GO:007568	9.3	EPO, TACR3, NOS3, CALCA, ALDOC, AMH
37	cell-cell signaling	GO:007267	9.3	PCSK1, ESR2, GHRH, TRH, PTH, SST
38	response to estradiol stimulus	GO:032355	9.2	NOS3, TACR3, DHH, NPY1R, CYP19A1, GH1
39	platelet degranulation	GO:002576	8.8	TF, ALB, F5, F8, IGF1, APOA1
40	MAPK cascade	GO:000165	8.7	TNF, CCL3, IL1B, FGFR1, FGF8, INS
41	negative regulation of apoptotic process	GO:043066	8.7	ALB, GHRL, TNF, NOG, WT1, PROP1
42	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.7	TNFSF11, TNF, AMH, IL6, IL1B, INS
43	small molecule metabolic process	GO:044281	8.7	CYP19A1, SRD5A1, NOS3, NDUFS4, TYMP, STS
44	anti-apoptosis	GO:006916	8.5	EPO, PROK2, HIPK3, NOS3, TERT, TNF
45	response to hypoxia	GO:001666	8.5	ADIPOQ, PDE5A, NOS3, NOS1, PLAT, CRP
46	response to glucocorticoid stimulus	GO:051384	8.3	ADIPOQ, PLAT, TNF, IL6, IL1B, INSR
47	negative regulation of cell proliferation	GO:008285	8.2	GNRHR, TNF, DLG3, SST, NOS3, WT1
48	platelet activation	GO:030168	8.1	TF, ALB, F5, F8, IGF1, APOA1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	PTH, NR5A1, NOG, NOS1, HFE2, THRB
50	blood coagulation	GO:007596	7.6	F10, PLAT, NOS1, NOS3, PDE5A, TF

Molecular functions related to hypogonadism according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	10.3	RETN, GH1, PTH, SST, CRH, PRL
2	ferric iron binding	GO:008199	10.2	TF, FTL, FTH1, FXN
3	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.2	AR, ESR2, ESRRB, NR0B1, NR5A1
4	cholesterol binding	GO:015485	10.0	STAR, CRP, CYP11A1, IHH, APOA1
5	steroid hormone receptor activity	GO:003707	9.8	THRB, NR5A1, NR0B1, ESRRB, ESR2, VDR
6	protease binding	GO:002020	9.1	POLG, C10orf2, TNF, INS, SERPINE1, SERPINC1
7	growth factor activity	GO:008083	9.0	TYMP, GH1, AMH, IGF1, IL6, IL1B
8	protein binding	GO:005515	4.6	SULT2A1, SRY, CUL4B, NR0B1, NR5A1, CRH