MCID: HYP080
MIFTS: 60

Hypogonadism malady

Summaries for Hypogonadism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypogonadism is a medical term which describes a diminished functional activity of the gonads – the... more...

MalaCards: Hypogonadism is related to hypogonadotropism and kallmann syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds gnrh and testosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and prostate, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Hypogonadism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

hypogonadism 8 10 44 60


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Disease Ontology8 DOID:1924
MeSH34 D007006
SNOMED-CT56 48130008
NCIt39 C9227

Related Diseases for Hypogonadism

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17GeneCards, 18GeneDecks
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Diseases in the Hypogonadism family:

Hypogonadism Lhb-Related

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism31.4KISS1R, GNRH1
2kallmann syndrome30.7NSMF, GNRH1, GNRHR, KAL1, PROK2, NR0B1
3obesity30.7PHF6, SHBG, NR0B1, FGFR1, LEP
4infertility30.5LHCGR, GNRH1, GNRHR, SHBG, LEP
5klinefelter's syndrome30.4NSMF, GNRHR, FGFR1, TAC3, KISS1R
6prostate cancer30.3GNRH1, GNRHR, SHBG, NR0B1, FGFR1, KISS1
7hypothyroidism30.3LEP, SHBG
8gynecomastia30.2SHBG, GNRH1
9male infertility30.1GNRH1, SHBG
10azoospermia30.0NR0B1, SHBG, GNRH1, LHCGR
11gonadal dysgenesis30.0NR0B1
12hypopituitarism29.9LEP, SHBG, GNRH1
13prolactinoma29.9GNRHR, GNRH1
14impotence29.9SHBG
15premature ovarian failure29.9SHBG, GNRH1
16adenoma29.8LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
17amenorrhea29.8LEP, SHBG, GNRH1
18pseudohermaphroditism29.8LHCGR
19adenocarcinoma29.8GNRHR, FGFR1
20pituitary adenoma29.6GNRH1, GNRHR, NR0B1, LEP
21cryptorchidism29.6FGFR1, SHBG, KAL1, GNRH1
22pre-eclampsia29.6KISS1, LEP, TAC3, SHBG
23ovarian hyperstimulation syndrome29.6GNRH1
24breast cancer29.6GNRH1, GNRHR, SHBG, FGFR1, KISS1
25turner syndrome29.6GNRH1
26hypertension29.6LEP
27renal agenesis29.6KAL1
28acromegaly29.6LEP, SHBG, GNRH1
29ovarian disease29.6SHBG, GNRH1
30prostatitis10.4
31diabetes mellitus10.3
32cerebellar ataxia10.2
33cerebellar ataxia and hypogonadotropic hypogonadism10.2
34prader-willi syndrome10.2
35hypogonadotropic hypogonadism 9 with or without anosmia10.2
36hypogonadotropic hypogonadism 17 with or without anosmia10.2
37hypogonadotropic hypogonadism 2 with or without anosmia10.2
38hypogonadotropic hypogonadism 8 with or without anosmia10.2
39hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.2
40dilated cardiomyopathy with hypergonadotropic hypogonadism10.2
41isolated gonadotropin-releasing hormone deficiency10.2
42pol iii-related leukodystrophies10.2
43ichthyosis and male hypogonadism10.2
44mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.2
45hypogonadotropic hypogonadism 13 with or without anosmia10.2
46hypogonadotropic hypogonadism 15 with or without anosmia10.2
47hypogonadotropic hypogonadism 4 with or without anosmia10.2
48hypogonadotropic hypogonadism 18 with or without anosmia10.2
49hypogonadotropic hypogonadism 7 with or without anosmia10.2
50hypogonadotropic hypogonadism 11 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Clinical Features for Hypogonadism

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Drugs & Therapeutics for Hypogonadism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hypogonadism

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Anatomical Context for Hypogonadism

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32MalaCards
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MalaCards organs/tissues related to Hypogonadism:

32
Testes, Bone, Prostate, Ovary, Pituitary, Endothelial, Liver, Testis, Thyroid, Lung, Heart, Breast, Eye, Pineal, Hypothalamus, Adipocyte, Uterus, Kidney, Brain, Skin, Olfactory bulb, T cells

Animal Models for Hypogonadism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypogonadism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537911.0KISS1, LHB, LHCGR, GNRH1, GNRHR, NR0B1
2MP:000536710.8LHCGR, GNRH1, GNRHR, HFE2, FGFR1, LEP
3MP:001077110.8GNRHR, HFE2, FGFR1, KISS1R, KISS1, ALX4
4MP:000538110.7LHCGR, GNRH1, GNRHR, FGFR1, LEP, KISS1R
5MP:000538910.6LHB, LHCGR, GNRH1, GNRHR, NR0B1, HFE2

Publications for Hypogonadism

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50PubMed
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Articles related to Hypogonadism:

(show top 50)    (show all 955)
idTitleAuthorsYear
1
The prevalence of Hypogonadism among diabetic and non-diabetic men in Jordan. (24388552)
2013
2
Seasonal variations of plasma gonadotropin, prolactin, and testosterone levels in primary and secondary hypogonadism: evidence for an independent testicular role. (23013937)
2013
3
Hypogonadism in primary care: the lowdown on low testosterone. (24002551)
2013
4
A de novo mutation of DAX1 in a boy with congenital adrenal hypoplasia without hypogonadotropic hypogonadism. (24197767)
2013
5
Correction: R31C GNRH1 Mutation and Congenital Hypogonadotropic Hypogonadism. (23990862)
2013
6
Male hypogonadism at a tertiary care hospital in Karachi, Pakistan. (24397056)
2012
7
Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? (21671978)
2012
8
Enhanced immunological response by dendritic cells in male hypogonadism. (22957648)
2012
9
Genetics of male hypogonadotropic hypogonadism. (23330252)
2012
10
Application of hormonal treatment in hypogonadotropic hypogonadism: more than ten years experience. (21989858)
2012
11
Lower urinary tract symptoms and erectile dysfunction associated with depression among Japanese patients with late-onset hypogonadism symptoms. (20828247)
2011
12
Stress hypogonadism: not everything that suppresses must converge. (21252178)
2011
13
Relationship between depressive symptoms and hypogonadism in men with COPD. (21774576)
2011
14
Metabolic syndrome and the effect of testosterone treatment in young men with congenital hypogonadotropic hypogonadism. (21325471)
2011
15
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (20382689)
2010
16
Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1. (19489874)
2010
17
Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia. (20014135)
2010
18
Late-onset hypogonadism in middle-aged and elderly men. (21047239)
2010
19
Reproductive endocrinology: Late-onset hypogonadism: diagnostic categories defined. (20518099)
2010
20
Pharmacokinetics of 2 novel formulations of modified-release oral testosterone alone and with finasteride in normal men with experimental hypogonadism. (20378927)
2010
21
Comparision of reproductive outcome of the women with hypogonadotropic hypogonadism and tubal factor infertility. (21077502)
2010
22
Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients. (20795793)
2010
23
HJV hemochromatosis, iron overload, and hypogonadism in a Brazilian man: treatment with phlebotomy and deferasirox. (21071928)
2010
24
Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism? A comparison between idiopathic and secondary hypogonadotrophic hypogonadism. (19824804)
2009
25
Re: Christina Wang, Eberhard Nieschlag, Ronald Swerdloff, et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. Eur Urol 2009;55:121-30. (19081175)
2009
26
Improvement in reproductive parameters in hypogonadal female mice by regulated gene replacement therapy in the central nervous system. (17476303)
2007
27
Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. (17074994)
2006
28
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial. (17105798)
2006
29
Hypogonadism in male patients with cancer. (16688773)
2006
30
The vitamin D receptor fokI start codon polymorphism and bone mineral density in male hypogonadotrophic hypogonadism. (16370560)
2005
31
A new DAX1 gene mutation associated with congenital adrenal hypoplasia and hypogonadotropic hypogonadism. (15884018)
2005
32
Empty sella, hypogonadism and hypopituitarism secondary to moyamoya disease. (15925787)
2005
33
Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy. (15049966)
2004
34
Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. (12913736)
2003
35
Testosterone replacement therapy in male hypogonadism. (12906378)
2003
36
Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene. (10522996)
1999
37
Obesity in the Prader-Labhart-Willi syndrome is not due to leptin deficiency but is accentuated by hypogonadism in male patients. (10619990)
1999
38
The effect of parenteral testosterone replacement on prostate specific antigen in hypogonadal men with erectile dysfunction. (9334599)
1997
39
Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (8675564)
1996
40
The role of birth injury and the consequences of inadequately treated hypogonadism in longstanding panhypopituitarism. (8952130)
1996
41
Changes in anterior pituitary response in patients with idiopathic hypothalamic hypogonadism caused by pulsatile GnRH therapy and testosterone replacement. (7584521)
1995
42
Association of isolated hypogonadotropic hypogonadism, pronounced hypodontia and the Wolff-Parkinson-White syndrome. (8077894)
1994
43
High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. (7921222)
1994
44
Bone tissue in patients with hyperprolactinemic hypogonadism]. (1302840)
1992
45
Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)
1991
46
Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. (2687610)
1989
47
Cerebrovascular accident associated with testosterone therapy in a 21-year-old hypogonadal man. (3945252)
1986
48
Rud syndrome: congenital ichthyosis, hypogonadism, mental retardation, retinitis pigmentosa and hypertrophic polyneuropathy. (6182503)
1982
49
Perceptual abnormalities in patients with chromatin negative gonadal dysgenesis and hypogonadotropic hypogonadism. (7440090)
1980
50
HYPOGONADOTROPHIC HYPOGONADISM IN THE LAURENCE-MOON SYNDROME. (14112243)
1964

Genetic Variations for Hypogonadism

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Expression for genes affiliated with Hypogonadism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Hypogonadism

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1gnrh4411.5KISS1, LHB, LHCGR, NSMF, GNRH1, GNRHR
2testosterone44 59 11 2414.3LHCGR, NSMF, GNRH1, GNRHR, SHBG, NR0B1
3steroid4411.3LHCGR, GNRH1, GNRHR, KAL1, SHBG, NR0B1
4progesterone44 59 28 11 2415.2LHCGR, GNRH1, GNRHR, SHBG, NR0B1, FGFR1
5estradiol44 11 2413.2LHCGR, GNRH1, GNRHR, SHBG, TAC3, LEP
6acth4411.1LEP, NR0B1, SHBG, GNRH1, LHCGR
7cetrorelix44 28 1113.1LHCGR, GNRH1, GNRHR, LEP
8goserelin44 28 1113.1LHCGR, GNRH1, GNRHR, SHBG
9leuprolide acetate4411.1LHCGR, GNRH1, GNRHR, SHBG
10alanine4411.0LHCGR, GNRH1, GNRHR, SHBG, KISS1R, KISS1
11buserelin44 28 1113.0LHCGR, GNRH1, GNRHR
12dihydrotestosterone44 28 11 2414.0GNRH1, GNRHR, SHBG, LEP
13tibolone4411.0LEP, SHBG, GNRH1
14danazol44 11 2413.0GNRH1, GNRHR, SHBG
15flutamide44 59 1113.0LHCGR, GNRH1, SHBG
16dopamine44 28 11 2414.0TAC3, FGFR1, SHBG, GNRHR, GNRH1
17degarelix44 28 1112.9GNRHR, GNRH1
18estrogen4410.9TAC3
19histrelin28 4411.9GNRH1, GNRHR
20abarelix44 28 1112.9GNRH1, GNRHR
21bromocriptine28 44 1112.9GNRH1, GNRHR, SHBG
22antarelix44 2811.9GNRH1, GNRHR
23adenylate4410.9LHCGR, GNRH1, GNRHR, SHBG, FGFR1
24acyline4410.9GNRH1, GNRHR
25dehydroepiandrosterone sulfate4410.9LEP, SHBG, GNRH1
26antide44 2811.9GNRHR, GNRH1
27raloxifene44 28 49 1113.9GNRH1, GNRHR, SHBG
28ganirelix44 2811.9GNRHR, GNRH1
29d-trp6-lhrh4410.9GNRHR, GNRH1
30metformin44 49 1112.9GNRH1, SHBG, LEP
31ribonucleic acid4410.9FGFR1, GNRHR, GNRH1, LHCGR
32nafarelin44 59 28 1113.8GNRHR, GNRH1
33tamoxifen44 49 28 1113.8LEP, SHBG, GNRHR, GNRH1
34androstenedione44 2411.8GNRH1, SHBG, LEP
35ptx14410.7GNRHR, GNRH1
36progestin4410.7SHBG, GNRH1, LHCGR
37leuprolide44 59 28 1113.6GNRH1, GNRHR
38megestrol acetate4410.6LEP, SHBG
39allopregnanolone4410.5SHBG, GNRH1
40estrone44 28 11 2413.3LEP, SHBG, GNRH1

GO Terms for genes affiliated with Hypogonadism

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16Gene Ontology
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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7KISS1, LEP, TAC3, HFE2, KAL1, GNRH1
2extracellular regionGO:00557610.5KISS1, LHB, GNRH1, PROK2, SHBG, FGFR1

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPK cascadeGO:04341010.8KISS1, LEP, FGFR1
2positive regulation of luteinizing hormone secretionGO:03368610.7KISS1, LEP
3male gonad developmentGO:00858410.7LHB, LHCGR, NR0B1
4female pregnancyGO:00756510.7LEP, TAC3, GNRH1
5G-protein coupled receptor signaling pathwayGO:00718610.7KISS1R, PROK2, GNRHR, LHCGR
6cellular response to gonadotropin stimulusGO:07137110.6LHCGR, NSMF
7positive regulation of synaptic transmissionGO:05080610.5KISS1R, KISS1
8neuropeptide signaling pathwayGO:00721810.3KISS1R, TAC3, PROK2

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6LEP, GNRH1, LHB

Products for genes affiliated with Hypogonadism

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Sources for Hypogonadism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet