MCID: HYP080
MIFTS: 53

Hypogonadism malady

Categories: Endocrine diseases

Aliases & Classifications for Hypogonadism

Aliases & Descriptions for Hypogonadism:

Name: Hypogonadism 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1924
MeSH 42 D007006
NCIt 47 C9227
SNOMED-CT 64 48130008
UMLS 69 C0020619

Summaries for Hypogonadism

Disease Ontology : 12 A gonadal disease that is characterized by diminished functional activity of the gonads.

MalaCards based summary : Hypogonadism is related to hypogonadotropic hypogonadism 7 without anosmia and cerebellar ataxia and hypogonadotropic hypogonadism. An important gene associated with Hypogonadism is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Testosterone and Dihydrotachysterol have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and endocrine/exocrine gland

Wikipedia : 71 Hypogonadism means diminished functional activity of the gonads—the testes in males or the ovaries in... more...

Related Diseases for Hypogonadism

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
id Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 7 without anosmia 12.1
2 cerebellar ataxia and hypogonadotropic hypogonadism 12.1
3 hypogonadotropic hypogonadism 1 with or without anosmia 12.0
4 hypogonadotropic hypogonadism 2 with or without anosmia 12.0
5 hypogonadotropic hypogonadism with or without anosmia 12.0
6 hypogonadotropic hypogonadism 12 with or without anosmia 12.0
7 hypogonadotropic hypogonadism 13 with or without anosmia 12.0
8 hypogonadotropic hypogonadism 10 with or without anosmia 12.0
9 hypogonadotropic hypogonadism 15 with or without anosmia 12.0
10 hypogonadotropic hypogonadism 16 with or without anosmia 12.0
11 hypogonadotropic hypogonadism 11 with or without anosmia 12.0
12 hypogonadotropic hypogonadism 20 with or without anosmia 12.0
13 hypogonadotropic hypogonadism 14 with or without anosmia 12.0
14 hypogonadotropic hypogonadism 18 with or without anosmia 12.0
15 hypogonadotropic hypogonadism 8 with or without anosmia 12.0
16 hypogonadotropic hypogonadism 9 with or without anosmia 12.0
17 hypogonadotropic hypogonadism 3 with or without anosmia 12.0
18 hypogonadotropic hypogonadism 6 with or without anosmia 12.0
19 hypogonadotropic hypogonadism 4 with or without anosmia 12.0
20 hypogonadotropic hypogonadism 21 with anosmia 12.0
21 hypogonadotropic hypogonadism 17 with or without anosmia 12.0
22 hypogonadotropic hypogonadism 19 with or without anosmia 12.0
23 hypogonadotropic hypogonadism 5 with or without anosmia 12.0
24 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
25 hypogonadotropic hypogonadism 23 with or without anosmia 12.0
26 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
27 hypogonadotropic hypogonadism 24 without anosmia 11.9
28 adrenal hypoplasia, congenital, with hypogonadotropic hypogonadism 11.8
29 moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism 11.8
30 kallmann syndrome 11.8
31 normosmic congenital hypogonadotropic hypogonadism 11.7
32 ataxia - hypogonadism - choroidal dystrophy 11.7
33 malouf syndrome 11.7
34 deafness-hypogonadism syndrome 11.7
35 muscular dystrophy, congenital, with infantile cataract and hypogonadism 11.6
36 hypogonadism-cataract syndrome 11.6
37 hypergonadotropic hypogonadism and partial alopecia 11.6
38 hypogonadism, male, with mental retardation and skeletal anomalies 11.6
39 moebius axonal neuropathy hypogonadism 11.6
40 hydrocephalus obesity hypogonadism 11.6
41 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 11.6
42 mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity 11.6
43 boucher-neuhauser syndrome 11.6
44 microcephaly hypergonadotropic hypogonadism short stature 11.6
45 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.6
46 alopecia-mental retardation syndrome with convulsions and hypergonadotropic hypogonadism 11.6
47 intellectual disability, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity 11.6
48 diabetes hypogonadism deafness mental retardation 11.5
49 mental retardation dysmorphism hypogonadism diabetes 11.5
50 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 11.5

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to Hypogonadism

Symptoms & Phenotypes for Hypogonadism

GenomeRNAi Phenotypes related to Hypogonadism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.04 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.04 FGF8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.04 FGF17
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.04 SPRY4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.04 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.04 FGFR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.04 FGF8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.04 KISS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.04 KISS1R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.04 FGF8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.04 SPRY4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.04 KISS1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.04 FGFR1 KISS1 LHB KISS1R
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.04 FGF17
15 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.04 FGFR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.04 SPRY4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.04 LHB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.04 FGF8 KISS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.04 SPRY4
20 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.04 LHB
21 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.04 FGF17
22 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.04 FGF8
23 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.04 FGFR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.04 FGF8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.04 FGFR1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.04 FGF17 FGF8 LHB SPRY4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.04 FGFR1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.04 SPRY4
29 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.04 SPRY4 FGF17
30 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.04 KISS1R
31 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.04 FGF8 KISS1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.04 SPRY4
33 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.04 FGFR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.04 KISS1R
35 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.04 FGFR1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.04 FGF8
37 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.04 FGF17
38 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.04 LHB

MGI Mouse Phenotypes related to Hypogonadism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.24 CHD7 FGF8 FGFR1 FSHB GNRH1 GNRHR
2 cellular MP:0005384 10.13 FGF8 FGFR1 FSHB GNRHR KISS1R LHB
3 growth/size/body region MP:0005378 10.13 CHD7 DUSP6 GNRHR KISS1 KISS1R LHCGR
4 homeostasis/metabolism MP:0005376 10.13 DUSP6 FGF8 FGFR1 FSHB GNRH1 GNRHR
5 digestive/alimentary MP:0005381 10.06 CHD7 FGF8 FGFR1 GNRH1 GNRHR KISS1
6 nervous system MP:0003631 9.9 CHD7 FGF17 FGF8 FGFR1 GNRH1 KISS1
7 renal/urinary system MP:0005367 9.5 FGF8 FGFR1 GNRH1 GNRHR KISS1 KISS1R
8 reproductive system MP:0005389 9.5 FGFR1 FSHB GNRH1 GNRHR KISS1 KISS1R

Drugs & Therapeutics for Hypogonadism

Drugs for Hypogonadism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
2
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5281010 5311071
3
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
4
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
5
Progesterone Approved, Vet_approved Phase 4,Phase 3 57-83-0 5994
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757 53477783
7
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
8
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 152945 6918296
9
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 120511-73-1 2187
10
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
11
Menotropins Approved Phase 4 61489-71-2 5360545
12
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
13
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
14
decanoic acid Experimental Phase 4 334-48-5 2969
15
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
16 Testosterone undecanoate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Chorionic Gonadotropin Phase 4,Phase 3
18 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2
19 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20
Testosterone enanthate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 315-37-7 9416
21 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Vardenafil Dihydrochloride Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Vasodilator Agents Phase 4,Early Phase 1
28 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
29 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
30 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
31 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
33 vitamin d Phase 4,Phase 3,Phase 2
34 insulin Phase 4,Phase 3,Phase 2,Phase 1
35 Estradiol valerate Phase 4,Phase 3,Early Phase 1 979-32-8
36 Triptorelin Pamoate Phase 4
37 Mitogens Phase 4
38 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Contraceptive Agents Phase 4,Phase 3,Phase 2,Early Phase 1
40 Trace Elements Phase 4,Phase 3,Phase 2
41 Tranquilizing Agents Phase 4
42 Estradiol 17 beta-cypionate Phase 4,Phase 3,Early Phase 1
43 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Estradiol 3-benzoate Phase 4,Phase 3,Early Phase 1
45 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Vitamins Phase 4,Phase 3,Phase 2
47 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Polyestradiol phosphate Phase 4,Phase 3,Early Phase 1
49 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Fenugreek seed meal Phase 4

Interventional clinical trials:

(show top 50) (show all 321)
id Name Status NCT ID Phase
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4
2 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4
3 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4
4 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4
5 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4
7 Testosterone Replacement in Older Men and Atherosclerosis Progression Unknown status NCT00287586 Phase 4
8 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4
9 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4
10 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4
11 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4
12 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4
13 Sequential Therapy for Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4
14 Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment Completed NCT02111434 Phase 4
15 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4
16 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4
17 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4
18 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4
19 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4
20 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism Completed NCT02102646 Phase 4
21 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4
22 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4
23 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4
24 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4
25 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4
26 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4
27 Effect of Testosterone Replacement on Insulin Resistance Completed NCT00487734 Phase 4
28 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4
29 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4
30 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4
31 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4
32 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4
33 Aripiprazole and Prolactin Study Completed NCT01085383 Phase 4
34 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4
35 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
36 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4
37 Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ Recruiting NCT02937740 Phase 4
38 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Recruiting NCT02880280 Phase 4
39 Vitamin D Treatment and Hypogonadism in Men Recruiting NCT01748370 Phase 4
40 Testosterone Therapy in Hypogonadal Men Treated With Opioids Recruiting NCT02433730 Phase 4
41 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Recruiting NCT02959853 Phase 4
42 Subcutaneous vs. Intramuscular Testosterone Recruiting NCT03091348 Phase 4
43 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4
44 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Recruiting NCT02408445 Phase 4
45 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Active, not recruiting NCT02366975 Phase 4
46 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4
47 NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) Terminated NCT01092858 Phase 4
48 Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L]) Terminated NCT00328926 Phase 4
49 TOM: Testosterone in Older Men With Sarcopenia Terminated NCT00240981 Phase 4
50 Nebido Versus Placebo in Elderly Men With Typical Symptoms of Late Onset Hypogonadism Over a Period of 54 Weeks Withdrawn NCT00710827 Phase 4

Search NIH Clinical Center for Hypogonadism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypogonadism

Genetic Tests for Hypogonadism

Genetic tests related to Hypogonadism:

id Genetic test Affiliating Genes
1 Hypogonadism 29

Anatomical Context for Hypogonadism

MalaCards organs/tissues related to Hypogonadism:

39
Testes, Bone, Prostate, Ovary, Pituitary, Endothelial, Liver

Publications for Hypogonadism

Articles related to Hypogonadism:

(show top 50) (show all 1131)
id Title Authors Year
1
Boucher NeuhAouser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. ( 27866050 )
2017
2
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone I^-subunit gene. ( 28092701 )
2017
3
Anosmia with hypogonadism: but NOT Kallmann syndrome. ( 28416537 )
2017
4
Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). ( 28067604 )
2017
5
The Utility of Sex Hormone Binding Globulin in Hypogonadism and Infertile Males. ( 28087298 )
2017
6
Delayed treatment of undescended testes may promote hypogonadism and infertility. ( 28070708 )
2017
7
Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center. ( 27927844 )
2017
8
HIV and hypogonadism: a new challenge for young-aged and middle-aged men on effective antiretroviral therapy. ( 28081039 )
2017
9
FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split-Hand/Foot Malformation: Implications for the Promoter Region. ( 28087897 )
2017
10
Long-Term Follow-Up of Primary Medical Versus Surgical Treatment of Prolactinomas in Men: Effects on Hyperprolactinemia, Hypogonadism, and Bone Health. ( 27773859 )
2017
11
Approaches to male hypogonadism in primary care. ( 28085783 )
2017
12
Clinical Characteristics, Health Care Utilization and Costs Among Men with Primary or Secondary Hypogonadism in a US Commercially Insured Population. ( 27939338 )
2017
13
Hypogonadotropic hypogonadism in a female patient with congenital arhinia. ( 27941181 )
2017
14
Anti-MA1llerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH. ( 28324034 )
2017
15
Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy. ( 28084147 )
2017
16
Dopa-testotoxicosis: disruptive hypersexuality in hypogonadal men with prolactinomas treated with dopamine agonists. ( 27601019 )
2016
17
Should psoriasis be considered a risk factor for hypogonadism in male patients? A monocentric, prospective, observational pilot study. ( 27556231 )
2016
18
Clomiphene citrate treatment for late onset hypogonadism: rise and fall. ( 27622282 )
2016
19
Mesenchymal stem cells from human umbilical cord ameliorate testicular dysfunction in a male rat hypogonadism model. ( 27586027 )
2016
20
Comparison of bone mineral density in adolescent girls with the diagnosis of hypogonadotropic hypogonadism and hypergonadotropic hypogonadism. ( 27087454 )
2016
21
A case of dyskeratosis congenita associated with hypothyroidism and hypogonadism. ( 27376432 )
2016
22
Endocrinology Update: Testicular Hypogonadism. ( 27936533 )
2016
23
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. ( 27595632 )
2016
24
Reproductive endocrinology: New treatment protocol for hypogonadotropic hypogonadism. ( 27516343 )
2016
25
Obesity and Hypogonadism. ( 27132582 )
2016
26
Hypogonadism: Its Prevalence and Diagnosis. ( 27132573 )
2016
27
Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study. ( 27152882 )
2016
28
Prevalence of KISS1 Receptor mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study. ( 27094476 )
2016
29
Serum levels of enclomiphene and zuclomiphene in men with hypogonadism on long-term clomiphene citrate treatment. ( 27511863 )
2016
30
Hypogonadism. ( 27132586 )
2016
31
Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty. ( 27561106 )
2016
32
Acute endothelial response to testosterone gel administration in men with severe hypogonadism and its relationship to androgen receptor polymorphism: a pilot study. ( 26162521 )
2016
33
A Rare de novo Interstitial Duplication at 4p15.2 in a Boy with Severe Congenital Heart Defects, Limb Anomalies, Hypogonadism, and Global Developmental Delay. ( 28030855 )
2016
34
Kisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic. ( 27616469 )
2016
35
Expanding the CHARGE Geno-Phenotype: A Girl with Novel CHD7 Deletion, Hypogonadotropic Hypogonadism, and Agenesis of Uterus and Ovaries. ( 26741373 )
2016
36
Re: The Effect of Testosterone on Cardiometabolic Risk Factors in Atorvastatin-Treated Men with Late-Onset Hypogonadism. ( 27191101 )
2016
37
Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty. ( 27213784 )
2016
38
Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism. ( 27644703 )
2016
39
Hypogonadism and erectile dysfunction as harbingers of systemic disease. ( 27141446 )
2016
40
Idiopathic Hypogonadothropic Hypogonadism Due To Novel FGFR1 Mutations. ( 28008864 )
2016
41
Neuroradiological findings in hypogonadotropic hypogonadism. ( 27050382 )
2016
42
The plasma miR-125a, miR-361 and miR-133a are promising novel biomarkers for Late-Onset Hypogonadism. ( 27000524 )
2016
43
Current practice in treating adult female thalassemia major patients with hypogonadism: An International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine survey from Italy. ( 27867897 )
2016
44
Complete Idiopathic Hypogonadotropic Hypogonadism due to Homozygous GNRH1 Mutations in the Mutational Hot Spots in the Region Encoding the Decapeptide. ( 26595427 )
2016
45
Reversal of congenital hypogonadotropic hypogonadism in a man with Kallmann syndrome due to SOX10 mutation. ( 27616149 )
2016
46
Hypogonadism and sex steroid replacement therapy in girls with Turner syndrome. ( 27018757 )
2016
47
Hypogonadism. ( 27132585 )
2016
48
A Comparison of Secondary Polycythemia in Hypogonadal MenA Treated with Clomiphene Citrate versus Testosterone Replacement: A Multi-institutional Study. ( 27984109 )
2016
49
Testosterone Undecanoate improves Sexual Function in Men with Type 2 diabetes and Severe Hypogonadism: Results from a 30 week randomized placebo controlled study. ( 27124889 )
2016
50
Have the Testosterone Trials demonstrated the effectiveness of testosterone therapy in older men without classical hypogonadism? ( 27959352 )
2016

Variations for Hypogonadism

Expression for Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for Hypogonadism

Pathways related to Hypogonadism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 ANOS1 DUSP6 FGF17 FGF8 FGFR1 FSHB
2
Show member pathways
13.17 FSHB GNRH1 GNRHR KISS1 KISS1R LHB
3
Show member pathways
12.42 FGF17 FGF8 FGFR1 GNRH1 LHB
4
Show member pathways
12.28 ANOS1 FGF17 FGF8 FGFR1
5
Show member pathways
11.96 ANOS1 FGF17 FGF8 FGFR1
6
Show member pathways
11.57 FGF17 FGF8 FGFR1
7 11.34 FGF17 FGF8 FGFR1 GNRH1 LHB
8 11.2 FSHB LHB LHCGR
9 10.14 FSHB GNRH1 GNRHR LHB LHCGR

GO Terms for Hypogonadism

Cellular components related to Hypogonadism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ANOS1 FGF17 FSHB GNRH1 KISS1 LHB
2 extracellular region GO:0005576 9.32 ANOS1 FGF17 FGF8 FGFR1 FSHB GNRH1

Biological processes related to Hypogonadism according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 FGF17 FGF8 FGFR1 FSHB PROK2
2 cell-cell signaling GO:0007267 9.93 FGF17 FSHB GNRH1 LHB
3 MAPK cascade GO:0000165 9.9 DUSP6 FGF17 FGF8 FGFR1
4 phosphatidylinositol-mediated signaling GO:0048015 9.8 FGF17 FGF8 FGFR1
5 male gonad development GO:0008584 9.79 LHB LHCGR NR0B1
6 phosphatidylinositol phosphorylation GO:0046854 9.78 FGF17 FGF8 FGFR1
7 female pregnancy GO:0007565 9.77 FSHB GNRH1 TAC3
8 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.7 FGF17 FGF8 FGFR1
9 inner ear morphogenesis GO:0042472 9.67 CHD7 FGF8 FGFR1
10 peptide hormone processing GO:0016486 9.64 FSHB LHB
11 male genitalia development GO:0030539 9.63 FGF8 LHCGR
12 regulation of osteoclast differentiation GO:0045670 9.61 FSHB LHCGR
13 aorta morphogenesis GO:0035909 9.58 CHD7 FGF8
14 gonad development GO:0008406 9.58 FGF8 NR0B1
15 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.58 FGF17 FGF8 FGFR1
16 generation of neurons GO:0048699 9.57 FGF8 FGFR1
17 G-protein coupled receptor signaling pathway GO:0007186 9.56 GNRHR KISS1 KISS1R LHB LHCGR PROK2
18 branching involved in salivary gland morphogenesis GO:0060445 9.55 FGF8 FGFR1
19 male sex determination GO:0030238 9.54 GNRH1 NR0B1
20 organ induction GO:0001759 9.51 FGF8 FGFR1
21 tachykinin receptor signaling pathway GO:0007217 9.48 TAC3 TACR3
22 cellular response to gonadotropin stimulus GO:0071371 9.46 LHCGR NSMF
23 neuropeptide signaling pathway GO:0007218 9.46 KISS1R PROK2 PROKR2 TAC3
24 hormone-mediated signaling pathway GO:0009755 9.43 FSHB LHB LHCGR
25 follicle-stimulating hormone signaling pathway GO:0042699 9.37 FSHB LHCGR
26 progesterone biosynthetic process GO:0006701 9.32 FSHB LHB
27 fibroblast growth factor receptor signaling pathway GO:0008543 8.92 ANOS1 FGF17 FGF8 FGFR1
28 signal transduction GO:0007165 10.09 FGF17 FSHB GNRH1 GNRHR KISS1R LHB

Molecular functions related to Hypogonadism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGF17 FGF8 FGFR1
2 hormone activity GO:0005179 9.43 FSHB GNRH1 LHB
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 FGF17 FGF8 FGFR1
4 G-protein coupled peptide receptor activity GO:0008528 9.32 KISS1R LHCGR
5 protein-hormone receptor activity GO:0016500 8.96 GNRHR LHCGR
6 1-phosphatidylinositol-3-kinase activity GO:0016303 8.8 FGF17 FGF8 FGFR1

Sources for Hypogonadism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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