MCID: HYP080
MIFTS: 60

Hypogonadism malady

Endocrine diseases, Reproductive diseases categories
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Summaries for Hypogonadism

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Wikipedia:65 Hypogonadism is a medical term which describes a diminished functional activity of the gonads ? the... more...

MalaCards based summary: Hypogonadism is related to hypogonadotropism and klinefelter's syndrome. An important gene associated with Hypogonadism is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Ovarian steroidogenesis and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs bromocriptine and chlorotrianisene and the compounds degarelix and acyline have been mentioned in the context of this disorder. Affiliated tissues include testes, prostate and bone, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Hypogonadism

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Hypogonadism, Aliases & Descriptions:

Name: Hypogonadism 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:1924
MeSH34 D007006
SNOMED-CT57 48130008
NCIt39 C9227

Related Diseases for Hypogonadism

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Diseases in the Hypogonadism family:

Hypogonadism Lhb-Related

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 466)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism32.0GNRH1, KISS1R
2klinefelter's syndrome31.1GNRHR, KISS1R
3hypogonadotropic hypogonadism 8 with or without anosmia31.0KISS1R
4kallmann syndrome30.6GNRHR, NR0B1, GNRH1, LEP, KISS1R
5pseudohermaphroditism30.6LHCGR
6infertility30.6LHCGR, LEP, GNRHR, GNRH1
7azoospermia30.4NR0B1, GNRH1, LHCGR
8short stature30.4GNRH1, LEP, NR0B1
9prolactinoma30.3GNRHR, GNRH1
10amenorrhea30.2LEP, GNRH1
11hypopituitarism30.2GNRH1, LEP
12oligospermia30.1GNRHR, GNRH1
13addison's disease30.0NR0B1, GNRHR
14adenoma29.9NR0B1, LHCGR, GNRH1, GNRHR
15anovulation29.9GNRH1, LEP
16precocious puberty29.9LHCGR, NR0B1, GNRH1, GNRHR, LEP
17acromegaly29.8GNRH1, LEP
18pituitary adenoma29.6NR0B1, LEP, GNRHR, GNRH1
19breast cancer29.1NR0B1, LEP, LHCGR, GNRHR, GNRH1, DUSP6
20obesity10.5
21prostatitis10.5
22ataxia10.4
23mental retardation10.4
24diabetes mellitus10.3
25cerebellar ataxia10.3
26cerebellar ataxia and hypogonadotropic hypogonadism10.3
27penis agenesis10.3LHCGR, GNRH1
28hypogonadotropic hypogonadism 9 with or without anosmia10.3
29leiomyomatosis10.3LHCGR, GNRH1
30myoma10.3GNRH1, GNRHR
31prostate cancer10.3
32x-linked adrenal hypoplasia congenita10.3
33hypogonadotropic hypogonadism 2 with or without anosmia10.3
34aorta atresia10.3GNRHR, GNRH1
35prader-willi syndrome10.3
36hypothyroidism10.3
37hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
38ichthyosis and male hypogonadism10.3
39hypogonadotropic hypogonadism 14 with or without anosmia10.3
40abrikosov's tumor10.3LHCGR, GNRH1
41isolated gonadotropin-releasing hormone deficiency10.3
42dilated cardiomyopathy with hypergonadotropic hypogonadism10.3
43congenital adrenal hyperplasia10.2GNRH1, NR0B1
44pol iii-related leukodystrophies10.2
45boucher neuhauser syndrome10.2
46mental retardation, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity10.2
47hypogonadotropic hypogonadism 13 with or without anosmia10.2
48hypogonadotropic hypogonadism 15 with or without anosmia10.2
49hypogonadotropic hypogonadism 4 with or without anosmia10.2
50hypogonadotropic hypogonadism 18 with or without anosmia10.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to hypogonadism

Symptoms for Hypogonadism

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Genetic Tests for Hypogonadism

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Anatomical Context for Hypogonadism

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MalaCards organs/tissues related to Hypogonadism:

32
Testes, Prostate, Bone, Ovary, Pituitary, Endothelial, Liver, Testis, Thyroid, Eye, Heart, Lung, Breast, Brain, Adipocyte, Kidney, Skin, Uterus, Olfactory bulb, Hypothalamus, Pineal, Neutrophil, T cells

Animal Models for Hypogonadism or affiliated genes

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Publications for Hypogonadism

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Articles related to Hypogonadism:

(show top 50)    (show all 988)
idTitleAuthorsYear
1
Camurati-engelmann disease association with hypogonadism and primary hypothyroidism. (25389497)
2014
2
Hypogonadotropic hypogonadism in a female patient previously diagnosed as having waardenburg syndrome due to a sox10 mutation. (25273316)
2014
3
Alterations of the FSH and LH receptor genes and evaluation of sperm ultrastructure in men with idiopathic hypergonadotropic hypogonadism. (23884663)
2013
4
Insulinoma presenting with long-standing depression, primary hypogonadism, and sertoli cell only syndrome. (24455334)
2013
5
Registry of Hypogonadism in Men (RHYME): design of a multi-national longitudinal, observational registry of exogenous testosterone use in hypogonadal men. (23373674)
2013
6
Hypogonadism and neurological diseases. (23292617)
2013
7
Optimal diagnostic measures and thresholds for hypogonadism in men with HIV/AIDS: comparison between 2 transdermal testosterone replacement therapy gels. (23816769)
2013
8
Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy. (23794541)
2013
9
Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback. (23188540)
2013
10
Pituitary iron and volume predict hypogonadism in transfusional iron overload. (22213195)
2012
11
Approach to the male patient with congenital hypogonadotropic hypogonadism. (22392951)
2012
12
Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities. (22120930)
2012
13
Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadism. (21868746)
2012
14
Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism. (22341266)
2012
15
Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. (21464116)
2011
16
Assessment of possible effects for testosterone replacement therapy in men with symptomatic late-onset hypogonadism. (21219383)
2011
17
Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism. (20712429)
2011
18
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
19
Hypogonadism predisposes males to the development of behavioural and neuroplastic depressive phenotypes. (21481538)
2011
20
Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)
2010
21
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. (19656574)
2010
22
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (20382689)
2010
23
Hepatic failure-induced hypogonadism in a prostate cancer patient. (20688306)
2010
24
Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp. (19351723)
2009
25
Hypogonadism on admission to acute rehabilitation is correlated with lower functional status at admission and discharge. (19330595)
2009
26
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. (19535795)
2009
27
Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases. (19327165)
2009
28
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
29
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
30
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males. (19734692)
2009
31
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
32
The relationship between hypogonadism and erectile dysfunction. (18305486)
2008
33
Bilateral male breast cancer with male potential hypogonadism. (17543123)
2007
34
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1. (17167799)
2007
35
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
36
The value of pituitary magnetic resonance imaging in men with hypogonadism. (12913700)
2003
37
Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. (12913736)
2003
38
Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: a longitudinal pharmacogenetic study. (12727953)
2003
39
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. (11994356)
2002
40
Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. (10456179)
1999
41
MEHMO (mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly, obesity), a novel syndrome: assignment of disease locus to xp21.1-p22.13. (9781023)
1998
42
Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome. (9762009)
1998
43
DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)
1997
44
Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene. (7677154)
1995
45
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (7990958)
1994
46
Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. (8426037)
1993
47
Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. (1906410)
1991
48
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980
49
The Rud syndrome: ichthyosis, hypogonadism, mental retardation. (5173271)
1971
50
HYPOGONADOTROPHIC HYPOGONADISM IN THE LAURENCE-MOON SYNDROME. (14112243)
1964

Variations for Hypogonadism

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Expression for genes affiliated with Hypogonadism

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Expression patterns in normal tissues for genes affiliated with Hypogonadism

Search GEO for disease gene expression data for Hypogonadism.

Pathways for genes affiliated with Hypogonadism

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Pathways related to Hypogonadism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9LHB, LHCGR
2
Show member pathways
Peptide GPCRs37
9.6GNRHR, LHCGR, KISS1R
3
Show member pathways
9.6LHCGR, LHB, GNRHR
4
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.4GNRH1, LHB, GNRHR
5
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.3LHCGR, LHB, LEP
69.2GNRH1, LHCGR, LHB, GNRHR
7
Show member pathways
9.1GNRHR, GNRH1, TAC3, KISS1R
8
Show member pathways
8.0GNRHR, GNRH1, LEP, TAC3, LHB, LHCGR
9
Show member pathways
7.5LHCGR, LHB, LEP, GNRHR, GNRH1, DUSP6

Compounds for genes affiliated with Hypogonadism

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Compounds related to Hypogonadism according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1degarelix44 28 1112.2GNRH1, GNRHR
2acyline4410.2GNRHR, GNRH1
3histrelin44 2811.2GNRHR, GNRH1
4abarelix44 28 1112.2GNRHR, GNRH1
5antarelix44 2811.2GNRHR, GNRH1
6antide44 2811.1GNRHR, GNRH1
7ganirelix44 2811.1GNRHR, GNRH1
8d-trp6-lhrh4410.1GNRHR, GNRH1
9nafarelin44 61 28 1113.1GNRH1, GNRHR
10ptx14410.1GNRH1, GNRHR
11leuprolide44 61 28 1113.1GNRH1, GNRHR
12danazol44 24 1112.1GNRH1, GNRHR
13flutamide44 61 1112.1LHCGR, GNRH1
14goserelin44 28 1111.9LHCGR, GNRHR, GNRH1
15pkcs449.9GNRHR, GNRH1
16buserelin44 28 1111.9GNRH1, GNRHR, LHCGR
17leuprolide acetate449.9GNRH1, GNRHR, LHCGR
18bromocriptine44 28 1111.9GNRH1, GNRHR
19tibolone449.8GNRH1, LEP
20ribonucleic acid449.8LHCGR, GNRHR, GNRH1
21raloxifene44 50 28 1112.7GNRHR, GNRH1
22naloxone44 28 50 1112.6GNRH1, LEP
23capsaicin44 2810.6TAC3, LEP
24dihydrotestosterone44 28 24 1112.6LEP, GNRHR, GNRH1
25dehydroepiandrosterone sulfate449.5GNRH1, LEP
26tamoxifen44 50 28 1112.5GNRH1, GNRHR, LEP
27alanine449.4LHCGR, GNRHR, GNRH1, KISS1R
28cetrorelix44 28 1111.4GNRH1, GNRHR, LEP, LHCGR
29acth449.4LHCGR, LEP, GNRH1, NR0B1
30acetylcholine44 50 28 24 1113.3TAC3, GNRH1, LEP
31arginine449.3GNRH1, GNRHR, LEP, LHCGR
32glutamate449.2LHCGR, LEP, GNRHR, GNRH1
33progesterone44 28 61 24 1113.1LHCGR, LEP, GNRHR, GNRH1, NR0B1
34testosterone44 61 24 1112.0LHCGR, LEP, GNRHR, GNRH1, NR0B1
35estradiol44 24 1111.0LHCGR, LEP, GNRHR, GNRH1, TAC3
36steroid449.0NR0B1, GNRH1, GNRHR, LEP, LHCGR
37estrogen448.7LHCGR, LEP, GNRHR, GNRH1, NR0B1, TAC3
38cysteine448.6NR0B1, DUSP6, LEP, LHCGR
39gnrh448.1TAC3, LHCGR, LHB, LEP, GNRHR, GNRH1

GO Terms for genes affiliated with Hypogonadism

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Cellular components related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5TAC3, HFE2, GNRH1, LEP

Biological processes related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:0071869.6KISS1R, GNRHR, LHCGR
2male gonad developmentGO:0085849.4NR0B1, LHB, LHCGR
3female pregnancyGO:0075658.9TAC3, GNRH1, LEP

Molecular functions related to Hypogonadism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.2GNRH1, LEP, LHB

Products for genes affiliated with Hypogonadism

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Sources for Hypogonadism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet