MCID: HYP064
MIFTS: 35

Hypogonadotropism

Categories: Endocrine diseases

Aliases & Classifications for Hypogonadotropism

MalaCards integrated aliases for Hypogonadotropism:

Name: Hypogonadotropism 12 52 14
Hypogonadism 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7455

Summaries for Hypogonadotropism

MalaCards based summary : Hypogonadotropism, also known as hypogonadism, is related to hypogonadotropic hypogonadism and hypogonadotropic hypogonadism 7 without anosmia. An important gene associated with Hypogonadotropism is PRL (Prolactin), and among its related pathways/superpathways is Peptide ligand-binding receptors. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and testes, and related phenotypes are integument and liver/biliary system

Related Diseases for Hypogonadotropism

Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 12.2
2 hypogonadotropic hypogonadism 7 without anosmia 12.1
3 hypogonadotropic hypogonadism 12 with or without anosmia 12.1
4 cerebellar ataxia and hypogonadotropic hypogonadism 12.1
5 hypogonadotropic hypogonadism 1 with or without anosmia 12.1
6 hypogonadotropic hypogonadism 13 with or without anosmia 12.1
7 hypogonadotropic hypogonadism 15 with or without anosmia 12.1
8 hypogonadotropic hypogonadism 11 with or without anosmia 12.1
9 hypogonadotropic hypogonadism 16 with or without anosmia 12.1
10 hypogonadotropic hypogonadism 9 with or without anosmia 12.1
11 hypogonadotropic hypogonadism 10 with or without anosmia 12.1
12 hypogonadotropic hypogonadism 8 with or without anosmia 12.1
13 hypogonadotropic hypogonadism 4 with or without anosmia 12.1
14 hypogonadotropic hypogonadism 18 with or without anosmia 12.1
15 hypogonadotropic hypogonadism 17 with or without anosmia 12.1
16 hypogonadotropic hypogonadism 22, with or without anosmia 12.1
17 hypogonadotropic hypogonadism 20 with or without anosmia 12.1
18 hypogonadotropic hypogonadism 5 with or without anosmia 12.1
19 hypogonadotropic hypogonadism 6 with or without anosmia 12.1
20 hypogonadotropic hypogonadism 14 with or without anosmia 12.1
21 hypogonadotropic hypogonadism 19 with or without anosmia 12.1
22 hypogonadotropic hypogonadism 3 with or without anosmia 12.1
23 hypogonadotropic hypogonadism 21 with anosmia 12.1
24 hypogonadotropic hypogonadism 2 with or without anosmia 12.1
25 hypogonadotropic hypogonadism 23 with or without anosmia 12.0
26 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
27 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.0
28 hypogonadotropic hypogonadism 24 without anosmia 12.0
29 normosmic congenital hypogonadotropic hypogonadism 11.8
30 kallmann syndrome 11.8
31 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.6
32 multicore myopathy with mental retardation, short stature, and hypogonadotropic hypogonadism 11.6
33 hypogonadotropic hypogonadism without anosmia, x-linked 11.6
34 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 11.6
35 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 11.6
36 moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 11.6
37 adrenal hypoplasia, congenital 11.4
38 bosma arhinia microphthalmia syndrome 11.4
39 boucher-neuhauser syndrome 11.4
40 ataxia - hypogonadism - choroidal dystrophy 11.3
41 hemochromatosis 11.1
42 isolated gonadotropin-releasing hormone deficiency 11.0
43 pol iii-related leukodystrophies 10.9
44 hypogonadism 10.9
45 leukodystrophy, hypomyelinating, 11 10.8
46 oliver-mcfarlane syndrome 10.8
47 waardenburg syndrome, type 2e, with or without neurologic involvement 10.8
48 prok2-related isolated gonadotropin-releasing hormone deficiency 10.8
49 obesity, morbid, due to leptin receptor deficiency 10.6
50 congenital disorder of glycosylation, type it 10.6

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to Hypogonadotropism

Symptoms & Phenotypes for Hypogonadotropism

MGI Mouse Phenotypes related to Hypogonadotropism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.46 GNRH1 KISS1 KISS1R PRL
2 liver/biliary system MP:0005370 9.26 GNRH1 KISS1 KISS1R PRL
3 reproductive system MP:0005389 9.02 GNRH1 KISS1 KISS1R PRL RNF216

Drugs & Therapeutics for Hypogonadotropism

Drugs for Hypogonadotropism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
3
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5281010 5311071
4
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
5
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 152945 6918296
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757
7
Progesterone Approved, Vet_approved Phase 4,Phase 3 57-83-0 5994
8
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
9
Menotropins Approved Phase 4 61489-71-2, 9002-68-0 5360545
10
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 120511-73-1 2187
11
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
12
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
13
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
14
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
15
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
16 Chorionic Gonadotropin Phase 4,Phase 3
17 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
25 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
26 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
27 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28
Testosterone enanthate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 315-37-7 9416
29 Testosterone undecanoate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Vardenafil Dihydrochloride Phase 4
31 Vasodilator Agents Phase 4,Early Phase 1
32 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
34 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 insulin Phase 4,Phase 3,Phase 2,Phase 1
38 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1
39 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
40 Micronutrients Phase 4,Phase 3,Phase 2
41 Mitogens Phase 4
42 Trace Elements Phase 4,Phase 3,Phase 2
43 Vitamins Phase 4,Phase 3,Phase 2
44 decanoic acid Phase 4
45 Contraceptive Agents Phase 4,Phase 3,Phase 2,Early Phase 1
46 Luteolytic Agents Phase 4
47 Triptorelin Pamoate Phase 4
48 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Fenugreek seed meal Phase 4

Interventional clinical trials:

(show top 50) (show all 331)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4 Pulsatile Gonadotropin Releasing Hormone;Human chorionic gonadotropin;Urinary Follicle-Stimulating Hormone
2 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4 Testosterone
3 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
4 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4 androgel;androgel 10g;placebo
5 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4 Oral testosterone undecanoate;Transdermal testosterone gel (AndroGel)
7 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
8 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4 Testosterone enanthate (Sustanon 250 mg);Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU);Testosteron gel (Testojel 50 mg)
9 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4 Sustanon
10 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4 Testosteron
11 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4 Testosterone 250mg injection;Testosteron 50 mg transdermal gel
12 Sequential Therapy for Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4 Traditional intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH plus zinc
13 Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment Completed NCT02111434 Phase 4 Testosterone
14 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4 Testogel 50 mg transdermal gel;Testosterone 250mg injection
15 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4 Testosterone
16 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4 Testosteron 250mg injection;Testosterone 50mg transdermal application
17 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
18 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4 testosterone;placebo
19 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism Completed NCT02102646 Phase 4 Triptorelin
20 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4 AndroGel (testosterone gel) 1%
21 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
22 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4 Dutasteride;Testosterone gel;Placebo dutasteride
23 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
24 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
25 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4 Topical Testosterone Solution
26 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4 dutasteride;placebo
27 Effect of Testosterone Replacement on Insulin Resistance Completed NCT00487734 Phase 4 Placebo for testosterone gel
28 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
29 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
30 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4 Testosterone;0.9% saline
31 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
32 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
33 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4 Testosterone;Placebo
34 Aripiprazole and Prolactin Study Completed NCT01085383 Phase 4 Aripiprazole
35 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
36 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
37 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
38 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Recruiting NCT02880280 Phase 4 Human Menopausal Gonadotropin;Human Chorionic Gonadotropin
39 Vitamin D Treatment and Hypogonadism in Men Recruiting NCT01748370 Phase 4 Vitamin D supplementation in hypogonadal men;Vitamin D supplementation in eugonadal men;Placebo hypogonadal;Placebo eugonadal
40 Testosterone Therapy in Hypogonadal Men Treated With Opioids Recruiting NCT02433730 Phase 4 Testosterone;placebo
41 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Recruiting NCT02959853 Phase 4 Anastrazole
42 Subcutaneous vs. Intramuscular Testosterone Recruiting NCT03091348 Phase 4 Testosterone
43 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos
44 Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ Active, not recruiting NCT02937740 Phase 4 NATESTO Testosterone Nasal Gel
45 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
46 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Active, not recruiting NCT02408445 Phase 4 testosterone cypionate 200mg/ml
47 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Not yet recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
48 NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) Terminated NCT01092858 Phase 4 Testosterone Undeconate (Nebido, BAY86-5037);Placebo
49 Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L]) Terminated NCT00328926 Phase 4 Luveris® 75 IU;Luveris® 25 IU;Placebo;Recombinant human follicle stimulating hormone (r-hFSH);Recombinant human chorionic gonadotropin (r-hCG)
50 TOM: Testosterone in Older Men With Sarcopenia Terminated NCT00240981 Phase 4 Topical testosterone gel 1% (active formulation);Topical gel (placebo formulation)

Search NIH Clinical Center for Hypogonadotropism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hypogonadotropism

Anatomical Context for Hypogonadotropism

MalaCards organs/tissues related to Hypogonadotropism:

39
Bone, Prostate, Testes, Brain, Pituitary, Heart, Endothelial

Publications for Hypogonadotropism

Articles related to Hypogonadotropism:

(show top 50) (show all 402)
id Title Authors Year
1
Developing and evaluating rare disease educational materials co-created by expert clinicians and patients: the paradigm of congenital hypogonadotropic hypogonadism. ( 28320476 )
2017
2
Reversal of hypogonadotropic hypogonadism with spontaneous pregnancy in beta-thalassaemia major with transfusional haemosiderosis. ( 28830631 )
2017
3
A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. ( 28284037 )
2017
4
Clinical and genetic features of 64 young male paediatric patients with congenital hypogonadotropic hypogonadism. ( 28833369 )
2017
5
MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. ( 28218621 )
2017
6
Hypogonadotropic hypogonadism in a female patient with congenital arhinia. ( 27941181 )
2017
7
Bone mineral density in older patients with never-treated congenital hypogonadotropic hypogonadism. ( 28577250 )
2017
8
Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism. ( 28485664 )
2017
9
Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male. ( 28583920 )
2017
10
Boucher NeuhAouser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. ( 27866050 )
2017
11
Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism. ( 28698240 )
2017
12
Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. ( 28931393 )
2017
13
Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism. ( 28476224 )
2017
14
Anti-MA1llerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH. ( 28324034 )
2017
15
Characteristics of a nationwide cohort of patients presenting with Isolated Hypogonadotropic Hypogonadism (IHH). ( 28882981 )
2017
16
FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split-Hand/Foot Malformation: Implications for the Promoter Region. ( 28087897 )
2017
17
Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1. ( 28160246 )
2017
18
Hypogonadotropic hypogonadism in human immunodeficiency virus-infected men: uncommonly low testosterone levels. ( 28924485 )
2017
19
GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism. ( 28611058 )
2017
20
Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. ( 28694969 )
2017
21
CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism. ( 28324054 )
2017
22
Similarity of female central (hypogonadotropic) hypogonadism and postmenopause. ( 28438051 )
2017
23
Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center. ( 27927844 )
2017
24
KLB, encoding I^-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. ( 28754744 )
2017
25
Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism. ( 28915117 )
2017
26
SOX2 nonsense mutation in a patient clinically diagnosed with non-syndromic hypogonadotropic hypogonadism. ( 28659543 )
2017
27
Phenotypic spectrum of POLR3B mutations: isolated hypogonadotropic hypogonadism without neurological or dental anomalies. ( 27512013 )
2016
28
X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: Identification and inA vitro study of a novel small indel in the NR0B1 gene. ( 27035099 )
2016
29
Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism. ( 28051040 )
2016
30
Evaluation of Basal Serum Adrenocorticotropic Hormone and Cortisol Levels and Their Relationship with Nonalcoholic Fatty Liver Disease in Male Patients with Idiopathic Hypogonadotropic Hypogonadism. ( 27174321 )
2016
31
Neuroradiological findings in hypogonadotropic hypogonadism. ( 27050382 )
2016
32
Expanding the CHARGE Geno-Phenotype: A Girl with Novel CHD7 Deletion, Hypogonadotropic Hypogonadism, and Agenesis of Uterus and Ovaries. ( 26741373 )
2016
33
Targeted next generation sequencing approach identifies eighteen new candidate genes in normosmic hypogonadotropic hypogonadism and Kallmann syndrome. ( 27502037 )
2016
34
Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty. ( 27213784 )
2016
35
Circulating makorin ring-finger protein-3 (MKRN3) levels in healthy men and in men with hypogonadotropic hypogonadism. ( 26175221 )
2016
36
Adherence to treatment in men with hypogonadotropic hypogonadism. ( 27647266 )
2016
37
Hypogonadotropic hypogonadism and metabolic syndrome: insights from the high-fat diet experimental rabbit animal model. ( 27050381 )
2016
38
CCDC141 Mutation Identified in Anosmic Hypogonadotropic Hypogonadism (Kallmann Syndrome) Alters GnRH Neuronal Migration. ( 27014940 )
2016
39
Hypogonadotropic Hypogonadism and Short Stature in Patients with Diabetes due to Neurogenin 3 Deficiency. ( 27533310 )
2016
40
A successful healthy live birth from a female patient with hypogonadotropic hypogonadism and oocytes with unusually large cytoplasmic inclusions. ( 27203307 )
2016
41
Complete Idiopathic Hypogonadotropic Hypogonadism due to Homozygous GNRH1 Mutations in the Mutational Hot Spots in the Region Encoding the Decapeptide. ( 26595427 )
2016
42
Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1. ( 27086651 )
2016
43
Reproductive endocrinology: New treatment protocol for hypogonadotropic hypogonadism. ( 27516343 )
2016
44
Reversal of congenital hypogonadotropic hypogonadism in a man with Kallmann syndrome due to SOX10 mutation. ( 27616149 )
2016
45
Comparison of bone mineral density in adolescent girls with the diagnosis of hypogonadotropic hypogonadism and hypergonadotropic hypogonadism. ( 27087454 )
2016
46
Kisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic. ( 27616469 )
2016
47
Comment on reversal of hypogonadotropic hypogonadism in a Chinese cohort. ( 25814161 )
2015
48
Sequential versus Continual Purified Urinary FSH / hCG in Men with Idiopathic Hypogonadotropic Hypogonadism. ( 25825944 )
2015
49
Changes in Bone Mineral Density and Metabolic Parameters after Pulsatile Gonadorelin Treatment in Young Men with Hypogonadotropic Hypogonadism. ( 26417369 )
2015
50
Novel mutations of DAX1 (NR0B1) in two Chinese families with X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. ( 25968435 )
2015

Variations for Hypogonadotropism

Expression for Hypogonadotropism

Search GEO for disease gene expression data for Hypogonadotropism.

Pathways for Hypogonadotropism

GO Terms for Hypogonadotropism

Biological processes related to Hypogonadotropism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 8.62 GNRH1 PRL

Molecular functions related to Hypogonadotropism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GNRH1 PRL

Sources for Hypogonadotropism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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