MCID: HYP064
MIFTS: 39

Hypogonadotropism malady

Summaries for Hypogonadotropism

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MalaCards based summary: Hypogonadotropism, also known as hypogonadism, is related to hypogonadism and kallmann syndrome. An important gene associated with Hypogonadotropism is PRL (prolactin), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Peptide ligand-binding receptors. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds estradiol benzoate and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and testes, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypogonadotropism

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS
See all sources

Hypogonadotropism, Aliases & Descriptions:

Name: Hypogonadotropism 9 11 43
 
Hypogonadism 60


External Ids:

Disease Ontology9 DOID:7455

Related Diseases for Hypogonadotropism

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Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism31.6PRL, KISS1R, GNRH1
2kallmann syndrome31.1GNRH1, KISS1R
3amenorrhea30.6PRL, GNRH1
4infertility30.6PRL, GNRH1
5precocious puberty30.4GNRH1, PRL
6hyperprolactinemia30.3PRL, GNRH1
7klinefelter's syndrome30.3GNRH1, PRL, KISS1R
8azoospermia30.2PRL, GNRH1
9ovarian disease30.1GNRH1, PRL
10anovulation30.1PRL, GNRH1
11premature ovarian failure30.1GNRH1, PRL
12male infertility30.0PRL, GNRH1
13hypogonadotropic hypogonadism 2 with or without anosmia10.4
14cerebellar ataxia and hypogonadotropic hypogonadism10.4
15hypogonadotropic hypogonadism 9 with or without anosmia10.4
16hypogonadotropic hypogonadism 13 with or without anosmia10.4
17hypogonadotropic hypogonadism 11 with or without anosmia10.4
18hypogonadotropic hypogonadism 16 with or without anosmia10.4
19hypogonadotropic hypogonadism 12 with or without anosmia10.4
20hypogonadotropic hypogonadism 10 with or without anosmia10.4
21hypogonadotropic hypogonadism 8 with or without anosmia10.4
22hypogonadotropic hypogonadism 7 without anosmia10.4
23hypogonadotropic hypogonadism 1 with or without anosmia10.4
24mccune-albright syndrome, somatic, mosaic10.4GNRH1
25hypogonadotropic hypogonadism 15 with or without anosmia10.4
26hypogonadotropic hypogonadism 4 with or without anosmia10.4
27hypogonadotropic hypogonadism 6 with or without anosmia10.4
28hypogonadotropic hypogonadism 3 with or without anosmia10.4
29hypogonadotropic hypogonadism with or without anosmia10.4
30hypogonadotropic hypogonadism 21 with anosmia10.4
31isolated gonadotropin-releasing hormone deficiency10.4
32hypogonadotropic hypogonadism 18 with or without anosmia10.4
33hypogonadotropic hypogonadism 17 with or without anosmia10.4
34hypogonadotropic hypogonadism 20 with or without anosmia10.4
35hypogonadotropic hypogonadism 5 with or without anosmia10.4
36hypogonadotropic hypogonadism 14 with or without anosmia10.4
37hypogonadotropic hypogonadism 19 with or without anosmia10.4
38x-linked adrenal hypoplasia congenita10.4
39eunuchoidism familial hypogonadotropic10.4
40ataxia10.3
41obesity10.3
42pol iii-related leukodystrophies10.3
43normosmic congenital hypogonadotropic hypogonadism10.3
44leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism10.2
45leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism10.2
46penile disease10.2PRL, GNRH1
47hypothalamic disease10.2PRL, GNRH1
48sexual disorder10.2GNRH1, PRL
49diabetes insipidus, neurohypophyseal10.2GNRH1, PRL
50pituitary apoplexy10.2GNRH1, PRL

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to hypogonadotropism

Symptoms for Hypogonadotropism

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Genetic Tests for Hypogonadotropism

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Anatomical Context for Hypogonadotropism

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MalaCards organs/tissues related to Hypogonadotropism:

31
Bone, Pituitary, Testes, Eye, Prostate, Testis, Heart, Ovary, Olfactory bulb, Hypothalamus

Animal Models for Hypogonadotropism or affiliated genes

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MGI Mouse Phenotypes related to Hypogonadotropism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9KISS1R, PRL, GNRH1

Publications for Hypogonadotropism

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Articles related to Hypogonadotropism:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
Hypogonadotropic hypogonadism in a female patient previously diagnosed as having waardenburg syndrome due to a sox10 mutation. (25273316)
2014
2
Pubertal induction in adult males with isolated hypogonadotropic hypogonadism using long-acting intramuscular testosterone undecanoate 1-g depot (Nebido(Ar) ). (23383861)
2014
3
Late onset X-linked adrenal hypoplasia congenita with hypogonadotropic hypgonadism due to a novel 4-bp deletion in exon 2 of NR0B1. (25003377)
2014
4
Hormone replacement therapy in children with hypogonadotropic hypogonadism: where do we stand? (23807524)
2013
5
Assisted reproductive technique outcomes in hypogonadotropic hypogonadism women. (23793424)
2013
6
Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. (23482592)
2013
7
Approach to the male patient with congenital hypogonadotropic hypogonadism. (22392951)
2012
8
Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism. (22766261)
2012
9
A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain. (23326276)
2012
10
Congenital adrenal hypoplasia and hypogonadotropic hypogonadism: phenotypic variability of the DAX-1 gene R267P mutation. (21925982)
2012
11
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
12
Hypogonadotropic hypogonadism due to GnRH receptor mutation in a sibling. (21717411)
2011
13
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (21856375)
2011
14
Large deletion in the KAL1 gene in two related patients with hypogonadotropic hypogonadism: diagnostic usefulness of cytogenetic and molecular methods. (21717404)
2011
15
Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. (20414046)
2011
16
Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)
2010
17
Kallmann Syndrome and hypogonadotropic Hypogonadism.Concluding remarks. (20389094)
2010
18
Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1. (19489874)
2010
19
Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. (19923792)
2010
20
Neurokinin B and its receptor in hypogonadotropic hypogonadism. (20389091)
2010
21
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. (19535795)
2009
22
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
23
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
24
Epidemiology, diagnosis, and treatment of male hypogonadotropic hypogonadism. (19955846)
2009
25
The genetics of idiopathic hypogonadotropic hypogonadism:unraveling the biology of human sexual development. (19396025)
2009
26
Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism. (18946744)
2008
27
Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism. (17140570)
2007
28
Reversal of idiopathic hypogonadotropic hypogonadism. (17761590)
2007
29
Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. (17164310)
2007
30
Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. (17074994)
2006
31
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
32
In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. (15728205)
2005
33
Hypogonadotropic hypogonadism due to loss of function of the KiSS1- derived peptide receptor GPR54. (12944565)
2003
34
Inv(10) in a patient with hypogonadotropic hypogonadism. (12773801)
2003
35
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. (11994356)
2002
36
Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. (12444893)
2002
37
A practical GnRH analogue (triptorelin) stimulation test to distinguish constitutional delay of puberty from hypogonadotropic hypogonadism in prepubertal boys. (11432487)
2001
38
Decrease of serum leptin levels in adult male with idiopathic hypogonadotropic hypogonadism (IHH) treated with pulsatile gonadotropin-releasing hormone (GnRH). (11263471)
2001
39
The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. (10634365)
2000
40
A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism. (10675358)
2000
41
Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. (10456179)
1999
42
Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)
1999
43
DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)
1997
44
The association of premature ejaculation and hypogonadotropic hypogonadism. (9292835)
1997
45
Hypogonadotropic patients with ultrasonographically detected polycystic ovaries: endocrine response to pulsatile gonadotropin-releasing hormone. (8915662)
1996
46
Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (8675564)
1996
47
Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty. (7608268)
1995
48
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (7990958)
1994
49
Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. (1906410)
1991
50
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980

Variations for Hypogonadotropism

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Expression for genes affiliated with Hypogonadotropism

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Search GEO for disease gene expression data for Hypogonadotropism.

Pathways for genes affiliated with Hypogonadotropism

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Compounds for genes affiliated with Hypogonadotropism

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Compounds related to Hypogonadotropism according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1estradiol benzoate439.9PRL, GNRH1
2leuprolide43 59 28 1212.9PRL, GNRH1
3mhpg439.9GNRH1, PRL
4buserelin43 28 1211.9PRL, GNRH1
5leuprolide acetate439.9PRL, GNRH1
6toremifene43 1210.9GNRH1, PRL
7clomiphene citrate439.9GNRH1, PRL
8naltrexone43 28 49 1212.9PRL, GNRH1
9metoclopramide43 49 1211.9GNRH1, PRL
10cabergoline43 28 1211.8GNRH1, PRL
11danazol43 24 1211.8GNRH1, PRL
12cyproteroneacetate439.8PRL, GNRH1
1317-hydroxyprogesterone43 2410.8GNRH1, PRL
14flutamide43 59 1211.8PRL, GNRH1
15bromocriptine43 28 1211.8GNRH1, PRL
16naloxone43 28 49 1212.8PRL, GNRH1
17dehydroepiandrosterone sulfate439.8PRL, GNRH1
18octreotide43 59 28 1212.8PRL, GNRH1
19opiate439.8GNRH1, PRL
20androstenedione43 2410.8PRL, GNRH1
21progestin439.7PRL, GNRH1
22mifepristone43 28 59 1212.7PRL, GNRH1
23estrone43 28 24 1212.7GNRH1, PRL
24cocaine43 1210.7PRL, GNRH1
25dihydrotestosterone43 28 24 1212.6PRL, GNRH1
265-hydroxytryptamine439.6PRL, GNRH1
27thyroxine43 2410.6GNRH1, PRL
28acth439.5PRL, GNRH1
29tamoxifen43 49 28 1212.5PRL, GNRH1
30epinephrine43 24 1211.4PRL, GNRH1
31gnrh439.3KISS1R, PRL, GNRH1
32ribonucleic acid439.2PRL, GNRH1

GO Terms for genes affiliated with Hypogonadotropism

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Biological processes related to Hypogonadotropism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00075659.5PRL, GNRH1

Molecular functions related to Hypogonadotropism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5PRL, GNRH1

Products for genes affiliated with Hypogonadotropism

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Sources for Hypogonadotropism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet