Hypogonadotropism malady

MalaCards: Hypogonadotropism, also known as hypogonadism, is related to isolated gonadotropin-releasing hormone (gnrh) deficiency and adrenal hypoplasia. An important gene associated with Hypogonadotropism is NR0B1 (nuclear receptor subfamily 0, group B, member 1), and among its related pathways are GnRH signaling pathway and Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q. The drugs estropipate and polyestradiol and the compounds glucose and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include ovary, prostate and pituitary, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Descriptions:

hypogonadotropism 6 8 32 hypogonadism 43

Diseases related to hypogonadotropism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 473)

id	Related Disease	Score	Top Affiliating Genes
1	isolated gonadotropin-releasing hormone (gnrh) deficiency	32.6	KISS1R, TACR3
2	adrenal hypoplasia	32.5	GNRH1, GK, ESRRB, NR0B1, NR5A1, STAR
3	klinefelter's syndrome	31.5	KISS1R, CHD7, FGFR1, GNRHR, TAC3, TACR3
4	x-linked adrenal hypoplasia congenita	31.4	GK, ESRRB, NR0B1, NR5A1, STAR
5	hypogonadism, hypergonadotropic	30.9	CYP19A1, SHBG, PRL
6	kallmann syndrome 1	30.2	KAL1, FGFR1
7	kallmann syndrome	29.0	KISS1, KISS1R, PCSK1, LHX3, LEP, LEPR
8	anosmia	29.0	CHD7, XG, KAL1, FGF8, FGFR1, GNRHR
9	delayed puberty	28.8	KISS1, KISS1R, LHCGR, LEP, CGA, CGB5
10	premature ovarian failure	28.3	GNRH1, SHBG, STAR, PRL
11	empty sella syndrome	28.1	LHX3, PRL, PROP1
12	leptin receptor deficiency	28.0	LEP, LEPR
13	leptin deficiency	27.9	LEP, LEPR, LSL
14	bardet-biedl syndrome	27.7	LEP, LEPR, CGA, INS, LSL
15	morbid obesity	27.7	LEP, LEPR, INS, GHRL, LSL
16	alopecia	27.4	RBM28, INS, F8, CYP19A1, SHBG, PRL
17	borjeson-forssman-lehmann syndrome	27.3	LHX3, HESX1, PROP1
18	male infertility	27.3	CGA, GNRH1, CYP19A1, SHBG
19	swyer syndrome	27.1	NR0B1, NR5A1, SHBG
20	premature ejaculation	27.1	LEP, CYP19A1, LSL, PRL
21	myotonic dystrophy	27.0	LEP, INS, F5, GHRH, CRH, SHBG
22	gonadotropin deficiency	27.0	KISS1R, CGA, KAL1, FGFR1, GNRH1, GNRHR
23	prolactinoma	26.8	BGLAP, CGA, INS, GNRH1, GNRHR, SST
24	gonadal dysgenesis	26.7	BRD2, BGLAP, CGB5, AMH, GNRH1, NR0B1
25	cerebellar hypoplasia	26.5	LHCGR, LHX3, CHD7, KAL1, GK, ESRRB
26	hemochromatosis	26.4	INS, F5, GNRH1, HFE, PRL
27	hypothyroidism	26.2	LEP, GHRL, SHBG, LSL
28	aromatase deficiency	26.1	BGLAP, INS, GNRH1, CYP19A1
29	acanthosis nigricans	25.9	LEP, INS, SHBG, PRL
30	azoospermia	25.9	BRD2, LHCGR, CGA, CGB5, FSHB, AMH
31	testicular cancer	25.9	CGA, CGB5, GNRH1, GHRH, SHBG
32	craniopharyngioma	25.8	BRD2, LEP, CGA, INS, GHRL, NR5A1
33	gynecomastia	25.4	RBM28, BRD2, LEP, CGA, CGB5, GNRH1
34	pituitary tumor	25.1	PCSK1, LEPR, FSHB, GNRH1, GNRHR, GHRH
35	glucose intolerance	25.1	LEP, LEPR, INS, GHRL, SHBG, LSL
36	liver cirrhosis	25.0	LEPR, F10, GHRH, CYP1A1, SST, LSL
37	familial male-limited precocious puberty	25.0	KISS1, LHCGR, LEP, CGA, CGB5, AMH
38	prader-willi syndrome	24.7	NDN, LEP, LEPR, INS, MAGEL2, GNRH1
39	turner syndrome	24.5	BGLAP, LEP, CGA, CGB5, INS, AMH
40	seizures	24.4	INS, F5, GHRH, GHRL, CYP19A1, SST
41	beta thalassemia	24.2	BGLAP, LEP, CGA, INS, F5, GNRH1
42	thalassemia	24.1	BGLAP, LEP, CGA, INS, F5, GNRH1
43	ovarian hyperstimulation syndrome	24.0	BRD2, LHCGR, LEP, CGA, CGB5, FSHB
44	choroiditis	23.4	LEPR, CD36, INS, F5, CYP1A1, CYP19A1
45	type 2 diabetes mellitus	23.4	PCSK1, LEP, LEPR, INS, F8, GHRL
46	prostate carcinoma	23.4	BGLAP, CGA, CD36, INS, FGF8, FGFR1
47	amenorrhea	23.0	BRD2, BGLAP, LHB, LHCGR, LEP, CGA
48	infertility	22.5	KISS1, KISS1R, BRD2, LHB, LHCGR, LEP
49	growth hormone deficiency	21.8	BGLAP, LHX3, LEP, LEPR, CD36, INS
50	hypogonadism	21.7	WDR11, NDN, KISS1, KISS1R, PCSK1, RBM28

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 black cohosh, black cohosh extract, bromocriptine, bromocriptine mesylate, chlorotrianisene, estradiol, estradiol 17-beta, estradiol acetate, estradiol cypionate, estradiol pwdr [va product], estradiol valerate, estrogens, estrogens,conjugated, estrogens,conjugated synthetic a, estrogens,conjugated synthetic b, estrogens,esterified, estrone, estrone sodium sulfate, estropipate, ethinyl estradiol, ethynodiol diacetate, fluoxymesterone, methyltestosterone, methyltestosterone pwdr [va product], norethindrone, norethindrone acetate, polyestradiol, polyestradiol phosphate, testosterone, testosterone cypionate, testosterone enanthate, testosterone propionate, testosterone propionate pwdr [va product], testosterone pwdr [va product]

MalaCards organs/tissues related to hypogonadotropism:

²²

MGI Mouse Phenotypes related to hypogonadotropism:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.2	FGF8, CHD7, PCSK1, KISS1R
2	renal/urinary system phenotype	MP:0005367	9.1	NOG, GNRHR, GNRH1, FGFR1, FGF8, INS
3	hearing/vestibular/ear phenotype	MP:0005377	8.9	HESX1, NOG, PLAT, CYP19A1, ESRRB, FGFR1
4	endocrine/exocrine gland phenotype	MP:0005379	8.3	LHCGR, LHX3, CHD7, FSHB, FGF8, FGFR1
5	no phenotypic analysis	MP:0003012	8.2	SST, CYP1A1, GHRL, ESRRB, AMH, FGFR1
6	skeleton phenotype	MP:0005390	7.8	EBF2, NPY1R, NDUFS4, NOG, PLAT, CYP19A1
7	integument phenotype	MP:0010771	7.4	CYP19A1, CRH, NOG, NDUFS4, PRL, PROKR2
8	adipose tissue phenotype	MP:0005375	7.4	EBF2, NPY1R, CYP19A1, GHRL, INS, CD36
9	muscle phenotype	MP:0005369	7.2	CYP19A1, PLAT, NOG, NDUFS4, NPY1R, FGFR1
10	normal phenotype	MP:0002873	6.9	NR5A1, CRH, NOG, NDUFS4, HESX1, HFE
11	reproductive system phenotype	MP:0005389	6.9	PCSK1, LHB, LHCGR, LHX3, LEP, LEPR
12	digestive/alimentary phenotype	MP:0005381	6.6	FGFR1, GNRH1, GNRHR, GHRL, SST, PLAT
13	liver/biliary system phenotype	MP:0005370	6.5	GK, GHRH, CYP1A1, CYP19A1, HFE, PRL
14	nervous system phenotype	MP:0003631	6.0	CYP19A1, NR5A1, CRH, NOG, NDUFS4, HESX1
15	cellular phenotype	MP:0005384	6.0	CRH, NR5A1, CYP19A1, GNRH1, PLAT, NOG
16	cardiovascular system phenotype	MP:0005385	5.8	CYP1A1, CYP19A1, NR5A1, PLAT, NOG, NDUFS4
17	growth/size phenotype	MP:0005378	5.3	CYP19A1, SST, NR5A1, CRH, PLAT, NOG
18	immune system phenotype	MP:0005387	5.1	GNRH1, CYP1A1, CYP19A1, SST, CRH, PLAT
19	mortality/aging	MP:0010768	4.9	NOG, PLAT, NR5A1, ESRRB, GK, HESX1
20	behavior/neurological phenotype	MP:0005386	4.1	F5, GK, ESRRB, GHRL, CYP19A1, SST
21	homeostasis/metabolism phenotype	MP:0005376	2.4	NDN, GNRH1, GNRHR, F10, GK, GHRH

Articles related to hypogonadotropism:

(show top 50)    (show all 139)

id	Title	Authors	Year	Affiliating Genes
1	A novel loss-of-function mutation in GPR54/KISS1R lea ds to hypogonadotropic hypogonadism in a highly consanguineous family. (21193544)	Nimri R.... Gat-Yablonski G.	2011	KISS1R
2	Mutation of the KAL1 gene in 30 male patients with i diopathic hypogonadotropic hypogonadism]. (21351529)	Ma C.... Liu R.Z.	2011	KAL1
3	Nasal embryonic LHRH factor (NELF) mutations in patie nts with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)	Xu N.... Layman L.C.	2011	NELF
4	Biochemical mechanism of pathogenesis of human gonado tropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated wi th familial hypogonadotropic hypogonadism. (21277937)	Maya-NA_A+ez G.... Conn P.M.	2011	GNRHR
5	Neurokinin B and its receptor in hypogonadotropic hyp ogonadism. (20389091)	Semple R.K.... Topaloglu A.K.	2010	TAC3
6	TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. (20194706)	Young J.... Guiochon-Mantel A.	2010	TACR3, TAC3
7	A novel homozygous splice acceptor site mutation of K ISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. (20371656)	Teles M.G.... Latronico A.C.	2010	KISS1R
8	Congenital hypogonadotropic hypogonadism in females: clinical spectrum, evaluation and genetics. (20363464)	Bry-Gauillard H.... Young J.	2010	FGFR1, LEP, LEPR
9	Screening of autosomal gene deletions in patients wit h hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplif ication: detection of a hemizygosis for the fibroblast growth factor receptor 1 . (19489874)	Trarbach E.B.... Latronico A.C.	2009	FGFR1, GNRHR, GNRH1
10	Partial hypogonadotropic hypogonadism associated with the Leu266Arg and Gln106Arg mutation of the gonadotropin-releasing hormone rec eptor. (19449676)	Quintos J.B.... New M.I.	2009	GNRHR
11	GNRH1 mutation in familial hypogonadotropic hypogona dism (19849976)	Bouligand J.... Young J.	2009	GNRH1
12	Prediction of testosterone response to human chorioni c gonadotrophin in idiopathic hypogonadotropic hypogonadism patients. (19245075)	Yazici M.... Kutlu M.	2009	CGA
13	Clinical and genetic analysis of a Korean patient with late-onset X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: identification of a novel mutation in the NR0B1 gene. (18380948)	Lee Y.W.... Kim C.H.	2008	NR0B1
14	The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (18463157)	Pedersen-White J.R.... Layman L.C.	2008	FGFR1, GNRHR, KAL1
15	Blood coagulation and fibrinolysis in male patients with hypogonadotropic hypogonadism: plasma factor V and factor X activities increase in hypogonadotropic hypogonadism. (18591887)	Erem C.... Yilmaz M.	2008	PLAT, F10, F8
16	Four Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism caused by DAX-1 gene mutations: mutant DAX-1 failed to repress steroidogenic acute regulatory protein (StAR) and luteinizing hormone beta-subunit gene promoter activity. (18202527)	Okuhara K.... Tajima T.	2008	NR0B1, STAR
17	Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism. (17140570)	Freitas K.C.... Latronico A.C.	2007	NPY1R
18	Reversal of idiopathic hypogonadotropic hypogonadism. (17761590)	Raivio T.... Pitteloud N.	2007	GNRH1
19	Effect of testosterone on insulin sensitivity in men with idiopathic hypogonadotropic hypogonadism. (17954419)	Naharci M.I.... Olgun A.	2007	INS
20	Hypogonadotropic hypogonadism. (17543719)	Layman L.C.	2007	KAL1, GNRH1
21	Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. (17726076)	Yialamas M.A.... Hayes F.J.	2007	LEP, INS
22	Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. (17074994)	Cerrato F.... Seminara S.B.	2006	KISS1R
23	Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. (15811136)	de Boer H.... Jansen M.	2005	CYP19A1
24	Testicular anti-mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. (15536161)	Young J.... Rey R.	2005	AMH
25	In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. (15728205)	Leanos-Miranda A.... Conn P.M.	2005	GNRHR
26	Molecular genetics of isolated hypogonadotropic hypogonadism and Kallmann syndrome. (15722618)	Karges B.... de Roux N.	2005	FGFR1
27	Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism--diagnostic and therapeutic aspects. (15554892)	Delemarre-van de Waal H.A.	2004	GNRH1
28	Hypogonadotropic hypogonadism due to loss of function of the KiSS1- derived peptide receptor GPR54. (12944565)	de Roux N.... Milgrom E.	2003	KISS1R, KISS1
29	Hypogonadotropic hypogonadism as a model of post-natal testicular anti-Mullerian hormone secretion in humans. (14656476)	Young J.... Chanson P.	2003	CYP1A1, CGA, AMH
30	The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty. (12824862)	Degros V.... Dewailly D.	2003	CGB5
31	A case of complete hypogonadotropic hypogonadism with a mutation in the gonadotropin-releasing hormone receptor gene. (12568864)	Wolczynski S.... Kottler M.L.	2003	GNRHR
32	Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. (11926704)	Hayashi M.... Ohkura T.	2002	CGA
33	A practical GnRH analogue (triptorelin) stimulation t est to distinguish constitutional delay of puberty from hypogonadotropic hypogo nadism in prepubertal boys. (11432487)	Ozkan B.... Bilginturan N.	2001	GNRH1
34	Decrease of serum leptin levels in adult male with id iopathic hypogonadotropic hypogonadism (IHH) treated with pulsatile gonadotropi n-releasing hormone (GnRH). (11263471)	Macut D.... Casanueva F.F.	2001	LSL
35	The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor. (11397842)	Pitteloud N.... Hayes F.J.	2001	GNRHR
36	Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)	Achermann J.C.... Jameson J.L.	1999	NR0B1, KAL1
37	Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. (9758439)	BA1chter D.... Nieschlag E.	1998	CGA, GNRH1
38	Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. (9100598)	Giustina A.... Veldhuis J.D.	1997	SST, GHRH
39	DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)	Kinoshita E.... Yorihuji T.	1997	NR0B1, GK
40	Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover. (9024272)	Guo C.Y.... Eastell R.	1997	CD36, CGA
41	Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility. (9010147)	Nachtigall L.B.... Crowley W.F.	1997	GNRH1
42	Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin production. (8770879)	Habiby R.L.... Jameson J.L.	1996	NR0B1, GNRH1
43	High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. (7921222)	Kliesch S.... Nieschlag E.	1994	GNRH1
44	Computer assisted sperm motility analysis at the moment of induced pregnancy during gonadotropin treatment for hypogonadotropic hypogonadism. (8282963)	Lenzi A.... Dondero F.	1993	CGA
45	Both hyper- and hypogonadotropic hypogonadism occur transiently in acute illness: bio- and immunoactive gonadotropins. (1464665)	Spratt D.I.... Orav J.	1992	PRL
46	Effects of decreasing exogenous GnRH pulse frequency on FSH and inhibin secretion in men with idiopathic hypogonadotropic hypogonadi sm. (1910242)	Wu F.C.... Sellar R.E.	1991	CYP19A1
47	Definitive localization of X-linked Kallman syndrome (hypogonadotropic hypogonadism and anosmia) to Xp22.3: close linkage to the hypervariable repeat sequence CRI-S232. (1977309)	Meitinger T.... Ballabio A.	1990	KAL1
48	Effect of hCG or hCG+ treatments in young thalassemic patients with hypogonadotropic hypogonadism. (2108196)	Balducci R.... Boscherini B.	1990	CGA
49	Congenital cerebellar hypoplasia and hypogonadotropic hypogonadism. (2243234)	Abs R.... Martin J.J.	1990	PRL
50	Hypogonadotropic hypogonadism in idiopathic hemochromatosis: evidence for combined hypothalamic and pituitary involvement. (2128941)	Siminoski K.... Walfish P.G.	1990	PRL

Genes related to hypogonadotropism according to GeneCards:

(show top 50)    (show all 59)

id	Symbol	Description	Score	GeneCards Section Context
1	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.1	Summaries, Publications
2	KISS1R	KISS1 receptor	11.1	Summaries, Publications
3	NELF	nasal embryonic LHRH factor	11.1	Publications, Summaries
4	GNRHR	gonadotropin-releasing hormone receptor	11.1	Publications, Summaries
5	TAC3	tachykinin 3	11.1	Publications, Summaries
6	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.1	Summaries, Publications
7	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Summaries
8	PROK2	prokineticin 2	11.0	Publications
9	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
10	CHD7	chromodomain helicase DNA binding protein 7	11.0	Publications
11	TACR3	tachykinin receptor 3	11.0	Publications
12	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	11.0	Publications
13	PRL	prolactin	11.0	Publications
14	MAGEL2	MAGE-like 2	11.0
15	PROP1	PROP paired-like homeobox 1	11.0	Publications
16	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
17	LHB	luteinizing hormone beta polypeptide	11.0	Publications
18	LHX3	LIM homeobox 3	11.0	Publications
19	HESX1	HESX homeobox 1	11.0	Publications
20	NDN	necdin homolog (mouse)	11.0	Publications
21	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications
22	FGF8	fibroblast growth factor 8 (androgen-induced)	11.0	Publications
23	KISS1	KiSS-1 metastasis-suppressor	11.0	Publications
24	NOG	noggin	11.0	Publications
25	POLR3A	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	11.0
26	AMH	anti-Mullerian hormone	11.0	Publications
27	RBM28	RNA binding motif protein 28	11.0
28	PROKR2	prokineticin receptor 2	11.0
29	GK	glycerol kinase	11.0	Publications
30	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
31	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
32	WDR11	WD repeat domain 11	11.0	Publications
33	NPY1R	neuropeptide Y receptor Y1	11.0	Publications
34	PCSK1	proprotein convertase subtilisin/kexin type 1	11.0	Publications
35	POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	11.0
36	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
37	STAR	steroidogenic acute regulatory protein	11.0	Publications
38	GHRH	growth hormone releasing hormone	11.0	Publications
39	ESRRB	estrogen-related receptor beta	11.0	Publications
40	BRD2	bromodomain containing 2	11.0
41	LEPR	leptin receptor	11.0	Publications
42	LSL	Leptin, serum levels of	11.0	Publications
43	EBF2	early B-cell factor 2	11.0	Publications
44	SHBG	sex hormone-binding globulin	11.0	Publications
45	F10	coagulation factor X	11.0	Publications
46	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
47	HFE	hemochromatosis	11.0
48	CRH	corticotropin releasing hormone	11.0	Publications
49	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
50	XG	Xg blood group	11.0	Publications

Pathways related to hypogonadotropism according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	GnRH signaling pathway20	10.2	LHB, CGA, FSHB, GNRH1, GNRHR
2	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	10.2	NPY1R, PROKR2, PROK2, TACR3, KISS1R
3	Apoptotic Pathways in Synovial Fibroblasts36	10.0	GHRH, GNRH1, FGFR1, FGF8, LHB
4	G alpha (q) signalling events38	9.9	KISS1, PROKR2, PROK2, TACR3, TAC3, GHRL
5	Development_Role of Activin A in cell differentiation and proliferation41	9.9	LHCGR, LHX3, CGA, FSHB, GNRHR, NR5A1
6	Development Role of Activin A in cell differentiation and proliferation10	9.9	STAR, LHB, LHCGR, LHX3, CGA, FSHB
7	eIF2 Pathway36	9.6	GHRH, GNRH1, FGFR1, FGF8, INS, LHB
8	Selected targets of CREB110	9.5	CRH, INS, PCSK1, KISS1
9	p70S6K Signaling36	9.4	GHRH, GNRH1, FGFR1, FGF8, INS, LHB
10	Selected targets of GCR-alpha10	9.3	LEP, CGA, FSHB, INS
11	Neuroactive ligand-receptor interaction20	9.3	NPY1R, PRL, TACR3, GNRHR, FSHB, CGA
12	Blood Coagulation Signaling Pathways37	8.8	PLAT, F10, F5, F8
13	Complement and coagulation cascades20	8.3	F10, F5, F8, PLAT

Compounds related to hypogonadotropism according to GeneDecks:

(show top 50)    (show all 216)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.4	PCSK1, FGFR1, KISS1
2	leuprolide32 42 9 9	13.1	LSL, GNRH1, CGB5, CGA, PRL, GNRHR
3	goserelin32 9 9	11.8	GNRH1, CGA, GNRHR, CYP19A1, SHBG, LSL
4	cetrorelix32 9 9	11.8	GNRHR, GNRH1, CGB5, CGA, LEP, LHCGR
5	leuprolide acetate32	9.7	LHCGR, PRL, SHBG, CYP19A1, GNRHR, GNRH1
6	buserelin32 9 9	11.6	GNRH1, GNRHR, CYP19A1, SST, PRL, LHCGR
7	17-hydroxyprogesterone32 18	10.5	PRL, SHBG, CRH, GNRH1, CGB5, CGA
8	flutamide32 9 9	11.4	SHBG, PRL, CYP19A1, CYP1A1, GNRH1, CGA
9	clomiphene citrate32	9.0	CGA, CGB5, FSHB, INS, GNRH1, CYP19A1
10	naloxone32 34 9 9	12.0	LEP, GHRL, GHRH, SST, CRH, GNRH1
11	dopamine32 9 18 9	11.8	GNRH1, GNRHR, ESRRB, GHRH, GHRL, SST
12	ribonucleic acid32	8.8	STAR, PCSK1, LHCGR, LEPR, CGA, NOG
13	forskolin32 42 9 9	11.7	GHRL, LHCGR, CGB5, FGF8, FGFR1, GNRHR
14	corticosterone32 18	9.7	CRH, LSL, STAR, PRL, BGLAP, NR5A1
15	tibolone32	8.6	LSL, BGLAP, F5, GNRH1, CYP19A1, LEP
16	estrone32 9 18 9	11.6	GNRH1, CGB5, CYP1A1, CYP19A1, NR5A1, SHBG
17	acipimox32	8.6	LEP, INS, GHRH, GHRL, LSL, SST
18	progestin32	8.5	PRL, CYP19A1, STAR, SHBG, GNRH1, F5
19	cyproteroneacetate32	8.5	SHBG, F5, GHRL, GNRH1, INS, BGLAP
20	octreotide32 42 9 9	11.5	LSL, INS, GNRH1, PRL, CRH, SST
21	dehydroepiandrosterone sulfate32	8.2	PRL, LSL, SHBG, CRH, NR5A1, CYP19A1
22	dhea32	8.1	CYP19A1, GHRL, INS, CGB5, LEP, CRH
23	raloxifene32 9 9	10.1	GNRH1, BGLAP, F5, GNRHR, CYP19A1, SHBG
24	metformin32 34 9 9	11.1	GNRH1, LSL, SHBG, CYP19A1, GHRL, F5
25	creatinine32	7.9	CGA, CGB5, LEP, SHBG, CRH, GHRL
26	androstenedione32 18	8.9	CYP19A1, CRH, SHBG, LSL, STAR, PRL
27	aspartate32	7.7	LHCGR, F10, GHRH, CYP19A1, GNRH1, F5
28	adenylate32	7.7	GNRHR, F10, GHRH, GHRL, TACR3, SST
29	heparin32 9 18 9	10.6	BGLAP, CGA, CD36, KAL1, FGF8, FGFR1
30	glutamate32	7.6	LHCGR, LEP, LEPR, INS, NDUFS4, PLAT
31	epinephrine32 9 18 9	10.5	LSL, LEP, CGA, CGB5, INS, F8
32	progesterone32 42 9 18 9	11.3	KISS1, PCSK1, LHCGR, LEPR, CGA, PLAT
33	thyroxine32 18	8.3	SHBG, PLAT, CRH, SST, GHRL, GHRH
34	estradiol32 9 18 9	10.2	LHCGR, LEPR, CGA, CGB5, FSHB, F8
35	tamoxifen32 34 9 9	10.1	GHRH, CYP1A1, CYP19A1, PLAT, SHBG, LSL
36	norepinephrine32 9 18 9	10.0	GNRH1, F8, INS, CGB5, CGA, LEP
37	acth32	7.0	SHBG, CRH, NR5A1, NR0B1, SST, GHRL
38	gnrh32	6.9	SHBG, CRH, NR0B1, GHRL, GHRH, ESRRB
39	lactate32	6.9	GNRH1, F8, FGFR1, INS, CGB5, CGA
40	hydrocortisone32 9 9	8.9	F5, GHRL, INS, CYP19A1, CD36, LSL
41	testosterone32 9 18 9	9.8	SST, CYP1A1, GNRHR, GNRH1, F5, AMH
42	cycloheximide32	6.6	GHRH, GNRHR, CD36, CGB5, CGA, LEP
43	alanine32	6.5	LEPR, LHCGR, KISS1R, KISS1, STAR, BGLAP
44	steroid32	6.4	F5, GNRHR, ESRRB, GHRH, CYP19A1, NR0B1
45	cholesterol32 9 18 9	9.3	F5, GHRH, GHRL, NR5A1, SHBG, LSL
46	vegf32	5.7	F10, GHRL, CYP1A1, SST, NOG, LSL
47	arginine32	5.3	PCSK1, BGLAP, LHCGR, LEP, LEPR, CGA
48	dexamethasone32 42 34 9 9	9.2	F8, GNRH1, ESRRB, GHRH, GHRL, CYP1A1
49	serine32	4.5	GHRL, F8, F5, F10, NOG, PLAT
50	estrogen32	3.4	STAR, TAC3, HFE, LSL, CRH, NR5A1

Cellular components related to hypogonadotropism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.1	PCSK1, INS, GHRL, PLAT
2	extracellular space	GO:005615	5.6	GNRH1, GHRH, GHRL, SST, CRH, PLAT
3	extracellular region	GO:005576	4.8	PRL, F10, GHRH, GHRL, SST, CRH

Biological processes related to hypogonadotropism according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	gonad development	GO:008406	10.4	NR0B1, FGF8, CGA
2	pituitary gland development	GO:021983	10.3	NOG, NR0B1, LHX3, PCSK1
3	peptide hormone processing	GO:016486	10.3	FSHB, CGA, LHB, PCSK1
4	response to morphine	GO:043278	10.1	TACR3, TAC3, CYP19A1, PCSK1
5	negative regulation of circadian sleep/wake cycle, REM sleep	GO:042322	10.0	GHRL, CRH
6	male gonad development	GO:008584	10.0	NR5A1, NR0B1, CYP19A1, LHCGR, LHB
7	positive regulation of cortisol secretion	GO:051464	10.0	GHRL, CRH
8	adrenal gland development	GO:030325	9.9	CRH, NR5A1, NR0B1, CYP19A1
9	bone development	GO:060348	9.9	CYP19A1, FGF8, BGLAP
10	steroid biosynthetic process	GO:006694	9.6	STAR, NR0B1, CYP19A1
11	female pregnancy	GO:007565	9.5	LEP, PRL, TAC3, HFE, CRH, GNRH1
12	G-protein coupled receptor signaling pathway	GO:007186	9.2	PROK2, SST, GHRL, GNRHR, INS, LHCGR
13	negative regulation of apoptotic process	GO:043066	9.1	LHX3, LEP, INS, FGFR1, GHRL, NOG
14	cell-cell signaling	GO:007267	9.0	NR5A1, SST, GHRH, GNRH1, AMH, INS
15	positive regulation of cell proliferation	GO:008284	9.0	LEP, CGA, FSHB, INS, FGF8, FGFR1
16	positive regulation of MAPK cascade	GO:043410	8.6	FGFR1, INS, CD36, LEP

Molecular functions related to hypogonadotropism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone-releasing hormone activity	GO:016608	10.1	GHRH, GHRL
2	hormone activity	GO:005179	8.0	LHB, PRL, CRH, SST, GNRH1, AMH