MCID: HYP064
MIFTS: 48

Hypogonadotropism malady

Summaries for Hypogonadotropism

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MalaCards: Hypogonadotropism is related to hypogonadism and kallmann syndrome. An important gene associated with Hypogonadotropism is KISS1R (KISS1 receptor), and among its related pathways are Tachykinin receptors bind tachykinins and Glycoprotein hormones. The compounds estrogen and danazol have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and testes, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hypogonadotropism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

hypogonadotropism 8 10 44


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Disease Ontology8 DOID:7455

Related Diseases for Hypogonadotropism

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17GeneCards, 18GeneDecks
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Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism31.6KISS1, LHCGR, GNRH1, GNRHR, KAL1, PRL
2kallmann syndrome30.8NR0B1, CHD7, FGFR1, FGF8, KISS1R, PROKR2
3infertility30.4LHCGR, GNRH1, GNRHR, PRL
4amenorrhea30.3GNRH1, PRL
5klinefelter's syndrome30.2GNRH1, GNRHR, KAL1, PRL, PROK2, PROKR2
6charge syndrome30.0CHD7
7male infertility30.0PRL, GNRH1
8azoospermia30.0LHCGR, GNRH1, PRL, NR0B1
9renal agenesis29.7KAL1
10cryptorchidism29.7GNRH1, KAL1, FGFR1
11leukodystrophy29.7POLR3A
12ovarian disease29.7PRL, GNRH1
13premature ovarian failure29.7PRL, GNRH1
14adenocarcinoma29.7FGFR1, GNRHR
15hypogonadotropic hypogonadism 9 with or without anosmia10.3
16hypogonadotropic hypogonadism 17 with or without anosmia10.3
17hypogonadotropic hypogonadism 2 with or without anosmia10.3
18hypogonadotropic hypogonadism 8 with or without anosmia10.3
19isolated gonadotropin-releasing hormone deficiency10.3
20cerebellar ataxia and hypogonadotropic hypogonadism10.3
21eunuchoidism familial hypogonadotropic10.3
22hypogonadotropic hypogonadism 13 with or without anosmia10.3
23hypogonadotropic hypogonadism 15 with or without anosmia10.3
24hypogonadotropic hypogonadism 4 with or without anosmia10.3
25hypogonadotropic hypogonadism 18 with or without anosmia10.3
26hypogonadotropic hypogonadism 7 with or without anosmia10.3
27hypogonadotropic hypogonadism 11 with or without anosmia10.3
28hypogonadotropic hypogonadism 16 with or without anosmia10.3
29hypogonadotropic hypogonadism 20 with or without anosmia10.3
30hypogonadotropic hypogonadism 12 with or without anosmia10.3
31hypogonadotropic hypogonadism 6 with or without anosmia10.3
32hypogonadotropic hypogonadism 14 with or without anosmia10.3
33hypogonadotropic hypogonadism 10 with or without anosmia10.3
34hypogonadotropic hypogonadism 19 with or without anosmia10.3
35hypogonadotropic hypogonadism 3 with or without anosmia10.3
36hypogonadotropic hypogonadism 21 with anosmia10.3
37hypogonadotropic hypogonadism 1 with or without anosmia10.3
38pol iii-related leukodystrophies10.3
39hypogonadotropic hypogonadism 5 with or without anosmia10.3
40obesity10.2
41premature ejaculation10.1
42gonadal dysgenesis10.1
43hyposmia - nasal and ocular hypoplasia - hypogonadotropic hypogonadism10.1
44hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome10.1
45pituitary hypoplasia10.0
46mccune albright syndrome10.0
47choroiditis10.0
48hyperprolactinemia10.0
49panhypopituitarism10.0
50hemochromatosis10.0

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to hypogonadotropism

Clinical Features for Hypogonadotropism

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Drugs & Therapeutics for Hypogonadotropism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypogonadotropism

Drug clinical trials:

Search ClinicalTrials for Hypogonadotropism

Search NIH Clinical Center for Hypogonadotropism

Search CenterWatch for Hypogonadotropism

Genetic Tests for Hypogonadotropism

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Anatomical Context for Hypogonadotropism

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32MalaCards
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MalaCards organs/tissues related to Hypogonadotropism:

32
Bone, Pituitary, Testes, Prostate, Testis, Eye, Heart, Ovary, Hypothalamus, Olfactory bulb

Animal Models for Hypogonadotropism or affiliated genes

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36MGI
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Publications for Hypogonadotropism

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50PubMed
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Articles related to Hypogonadotropism:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. (23482592)
2013
2
Comparative functional analysis of two fibroblast growth factor receptor 1 (FGFR1) mutations affecting the same residue (R254W and R254Q) in isolated hypogonadotropic hypogonadism (IHH). (23276709)
2013
3
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism. (23337528)
2013
4
Reversal of Isolated Hypogonadotropic Hypogonadism: long-term integrity of hypothalamo-pituitary-testicular axis in two men is dependent on intermittent androgen exposure. (24118132)
2013
5
Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. (23355746)
2013
6
Erratum to "Hypogonadotropic Hypogonadism Associated with Hereditary Hemorrhagic Telangiectasia" (23956891)
2013
7
Progression of puberty after initiation of androgen therapy in patients with idiopathic hypogonadotropic hypogonadism. (24083166)
2013
8
Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism. (22766261)
2012
9
Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. (22723321)
2012
10
Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. (22072740)
2012
11
Effectiveness of gonadotropin administration for spermatogenesis induction in hypogonadotropic hypogonadism: a possible role of androgen receptor CAG repeat polymorphism and therapeutic measures. (22385118)
2012
12
A novel severe N-terminal splice site KISS1R gene mutation causes hypogonadotropic hypogonadism but enables a normal development of neonatal external genitalia. (22619348)
2012
13
Role of basal and provocative serum prolactin in differentiating idiopathic hypogonadotropic hypogonadism and constitutional delayed puberty--a diagnostic dilemma. (24397058)
2012
14
Birth after TESE-ICSI in a man with hypogonadotropic hypogonadism and congenital adrenal hypoplasia linked to a DAX-1 (NR0B1) mutation. (21227944)
2011
15
Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. (21543378)
2011
16
Hypogonadotropic hypogonadism in a homozygous MC4R mutation carrier and the effect of sibutramine treatment on body weight and obesity-related health risks. (21921657)
2011
17
Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. (19923792)
2010
18
The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism. (20591981)
2010
19
Genetics: Gonadotropin deficiency in genetic form of congenital hypogonadotropic hypogonadism is of hypothalamic origin. (20518125)
2010
20
Efficacy of recombinant human follicle stimulating hormone at low doses in inducing spermatogenesis and fertility in hypogonadotropic hypogonadism. (20436264)
2010
21
Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty. (20826577)
2010
22
Adult-onset idiopathic hypogonadotropic hypogonadism: possible aetiology, clinical manifestations and management. (20531282)
2010
23
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
24
Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. (19755480)
2009
25
A case of adult-onset idiopathic hypogonadotropic hypogonadism presenting with infertility]. (19673435)
2009
26
The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. (19707180)
2009
27
Hypogonadotropic hypogonadism. (17543719)
2007
28
X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: report on new mutation of the DAX-1 gene in two siblings. (16553032)
2006
29
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
30
Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. (16322390)
2005
31
Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) in hypogonadotropic hypogonadism with persistent azoospermia after hormonal therapy. (15202738)
2004
32
A case report of idiopathic hypogonadotropic hypogonadism with particular reference to monitoring of prostate volume]. (15334897)
2004
33
Analysis of the PROP1 gene in a large cohort of patients with idiopathic hypogonadotropic hypogonadism. (14678304)
2004
34
Inv(10) in a patient with hypogonadotropic hypogonadism. (12773801)
2003
35
A case of complete hypogonadotropic hypogonadism with a mutation in the gonadotropin-releasing hormone receptor gene. (12568864)
2003
36
A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism. (10675358)
2000
37
A patient of hypogonadotropic hypogonadism accompanied by growth hormone deficiency and decreased bone mineral density who attained normal growth. (10939538)
2000
38
Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)
1999
39
A concomitant decrease in cortical and trabecular bone mass in isolated hypogonadotropic hypogonadism and gonadal dysgenesis. (10565254)
1999
40
AntimA1llerian hormone in patients with hypogonadotropic hypogonadism. (10443662)
1999
41
Effects of gonadotropin and testosterone treatments on plasma leptin levels in male patients with idiopathic hypogonadotropic hypogonadism and Klinefelter's syndrome. (9660087)
1998
42
Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. (9758439)
1998
43
New mutations of DAX-1 genes in two Japanese patients with X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. (8636263)
1996
44
Adrenal axis and hypogonadotropism in the growth-restricted female lamb. (8312437)
1994
45
Comparison between spontaneous gonadotropin concentration profiles and gonadotropin response to low-dose gonadotropin-releasing hormone in prepubertal and early pubertal boys and patients with hypogonadotropic hypogonadism: assessment by using ultrasensitive, time-resolved immunofluorometric assay. (1603636)
1992
46
McCune-Albright syndrome. A case of primary hypogonadism obscured by hyperprolactinemic hypogonadotropic hypogonadism. (2293479)
1990
47
Induction of pharmacological hypogonadotropism using gonadotropin-releasing hormone agonists in patients undergoing controlled ovarian stimulation. (2139863)
1990
48
The inability of adrenal androgens to stimulate the adult human prostate: an autopsy evaluation of men with hypogonadotropic hypogonadism and panhypopituitarism. (2945933)
1986
49
Isolated hypogonadotropic hypogonadism with syndactyly. (6093725)
1984
50
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980

Genetic Variations for Hypogonadotropism

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Expression for genes affiliated with Hypogonadotropism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadotropism

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Pathways for genes affiliated with Hypogonadotropism

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hypogonadotropism

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9TAC3
2danazol44 11 2412.8GNRHR
3degarelix44 28 1112.8GNRH1, GNRHR
4ssr 146977 hydrochloride5910.8TAC3, TACR3
5sb 21879559 2811.8TAC3, TACR3
6histrelin28 4411.8GNRH1, GNRHR
7sb 22220059 2811.8TAC3, TACR3
8abarelix44 28 1112.8GNRH1, GNRHR
9goserelin44 28 1112.7GNRHR, GNRH1, LHCGR
10antarelix44 2811.7GNRH1, GNRHR
11cetrorelix44 28 1112.7LHCGR, GNRH1, GNRHR
12acyline4410.7GNRH1, GNRHR
13ganirelix44 2811.7GNRH1, GNRHR
14leuprolide44 59 28 1113.7GNRH1, GNRHR, PRL
15antide44 2811.7GNRH1, GNRHR
16buserelin44 28 1112.7LHCGR, GNRH1, GNRHR, PRL
17leuprolide acetate4410.7LHCGR, GNRH1, GNRHR, PRL
18d-trp6-lhrh4410.7GNRH1, GNRHR
19flutamide44 59 1112.7LHCGR, GNRH1, PRL
20kassinin28 4411.7TAC3, TACR3
21bromocriptine28 44 1112.6PRL, GNRHR, GNRH1
22ribonucleic acid4410.6LHCGR, GNRH1, GNRHR, PRL, FGFR1
23eledoisin44 2811.6TAC3, TACR3
24senktide44 59 2812.6TAC3, TACR3
25forskolin44 49 1112.6LHCGR, GNRHR, FGF8, TACR3
26septide44 2811.6TAC3, TACR3
27estradiol44 11 2412.6TAC3, PRL, GNRHR, GNRH1, LHCGR
28acth4410.6LHCGR, GNRH1, PRL, NR0B1
29progesterone44 59 28 11 2414.5LHCGR, GNRH1, GNRHR, PRL, NR0B1, FGFR1
30nafarelin44 59 28 1113.5GNRHR, GNRH1
31dopamine44 28 11 2413.5NDUFS4, GNRH1, GNRHR, FGFR1, FGF8, TAC3
32glyceraldehyde 3-phosphate4410.5NDUFS4, FGFR1, KISS1R, KISS1
33steroid4410.5LHCGR, GNRH1, GNRHR, KAL1, PRL, NR0B1
34ptx14410.5GNRH1, GNRHR
35testosterone44 59 11 2413.4LHCGR, NSMF, GNRH1, GNRHR, PRL, NR0B1
36alanine4410.4LHCGR, GNRH1, GNRHR, TACR3, KISS1R, KISS1
37estradiol benzoate4410.4GNRH1, PRL
38mhpg4410.4PRL, GNRH1
39gnrh4410.4KISS1, LHCGR, NSMF, GNRH1, GNRHR, KAL1
40adenylate4410.3LHCGR, GNRH1, GNRHR, FGFR1, TACR3
41calcium44 49 11 2413.3LHCGR, NDUFS4, GNRHR, PROKR2, FGFR1, TAC3
42melatonin44 59 28 11 2414.2PRL, GNRHR, NDUFS4
43progestin4410.0LHCGR, GNRH1, PRL

GO Terms for genes affiliated with Hypogonadotropism

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16Gene Ontology
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Cellular components related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1KISS1, TAC3, FGF8, FGFR1, PROK2, PRL
2DNA-directed RNA polymerase III complexGO:00566610.0POLR3B, POLR3A

Biological processes related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tachykinin receptor signaling pathwayGO:00721710.6TACR3, TAC3
2ovulation cycleGO:04269810.6PRL, GNRH1
3positive regulation of synaptic transmissionGO:05080610.6KISS1, KISS1R
4circadian rhythmGO:00762310.6PROKR2, PROK2, PRL
5female pregnancyGO:00756510.5GNRH1, PRL, TAC3
6cellular response to gonadotropin stimulusGO:07137110.5NSMF, LHCGR
7branching involved in salivary gland morphogenesisGO:06044510.5FGFR1, FGF8
8neuropeptide signaling pathwayGO:00721810.5KISS1R, TAC3, PROK2
9male genitalia developmentGO:03053910.4FGF8, LHCGR
10organ inductionGO:00175910.4FGFR1, FGF8
11G-protein coupled receptor signaling pathwayGO:00718610.4KISS1R, PROK2, GNRHR, LHCGR
12transcription elongation from RNA polymerase III promoterGO:00638510.2POLR3B, POLR3A
13termination of RNA polymerase III transcriptionGO:00638610.0POLR3B, POLR3A

Molecular functions related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase III activityGO:00105610.3POLR3B, POLR3A
2ribonucleoside bindingGO:03254910.0POLR3B, POLR3A

Products for genes affiliated with Hypogonadotropism

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Sources for Hypogonadotropism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet