MCID: HYP064
MIFTS: 39

Hypogonadotropism malady

Endocrine diseases, Reproductive diseases categories

Summaries for Hypogonadotropism

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34MalaCards
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MalaCards: Hypogonadotropism is related to hypogonadism and kallmann syndrome. An important gene associated with Hypogonadotropism is PRL (prolactin), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Peptide ligand-binding receptors. The compounds estradiol benzoate and leuprolide have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and testes, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Hypogonadotropism

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Aliases & Descriptions:

hypogonadotropism 9 11 46


External Ids:

Disease Ontology9 DOID:7455

Related Diseases for Hypogonadotropism

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism31.6PRL, KISS1R, GNRH1
2kallmann syndrome30.9GNRH1, KISS1R
3infertility30.5PRL, GNRH1
4amenorrhea30.4PRL, GNRH1
5klinefelter's syndrome30.3GNRH1, PRL, KISS1R
6precocious puberty30.2GNRH1, PRL
7mccune albright syndrome30.2GNRH1
8hyperprolactinemia30.1PRL, GNRH1
9azoospermia30.1PRL, GNRH1
10ovarian disease29.9GNRH1, PRL
11premature ovarian failure29.9GNRH1, PRL
12male infertility29.9PRL, GNRH1
13hypogonadotropic hypogonadism 9 with or without anosmia10.4
14hypogonadotropic hypogonadism 17 with or without anosmia10.4
15hypogonadotropic hypogonadism 2 with or without anosmia10.4
16hypogonadotropic hypogonadism 8 with or without anosmia10.4
17isolated gonadotropin-releasing hormone deficiency10.3
18cerebellar ataxia and hypogonadotropic hypogonadism10.3
19eunuchoidism familial hypogonadotropic10.3
20hypogonadotropic hypogonadism 13 with or without anosmia10.3
21hypogonadotropic hypogonadism 15 with or without anosmia10.3
22hypogonadotropic hypogonadism 4 with or without anosmia10.3
23hypogonadotropic hypogonadism 18 with or without anosmia10.3
24hypogonadotropic hypogonadism 7 with or without anosmia10.3
25hypogonadotropic hypogonadism 11 with or without anosmia10.3
26hypogonadotropic hypogonadism 16 with or without anosmia10.3
27hypogonadotropic hypogonadism 20 with or without anosmia10.3
28hypogonadotropic hypogonadism 12 with or without anosmia10.3
29hypogonadotropic hypogonadism 6 with or without anosmia10.3
30hypogonadotropic hypogonadism 14 with or without anosmia10.3
31hypogonadotropic hypogonadism 10 with or without anosmia10.3
32hypogonadotropic hypogonadism 19 with or without anosmia10.3
33hypogonadotropic hypogonadism 3 with or without anosmia10.3
34hypogonadotropic hypogonadism 21 with anosmia10.3
35hypogonadotropic hypogonadism 1 with or without anosmia10.3
36pol iii-related leukodystrophies10.3
37x-linked adrenal hypoplasia congenita10.3
38hypogonadotropic hypogonadism 5 with or without anosmia10.3
39obesity10.3
40ataxia10.2
41boucher neuhauser syndrome10.2
42premature ejaculation10.1
43gonadal dysgenesis10.1
44hyposmia - nasal and ocular hypoplasia - hypogonadotropic hypogonadism10.1
45hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome10.1
46penile disease10.0PRL, GNRH1
47hypothalamic disease10.0PRL, GNRH1
48sexual disorder10.0GNRH1, PRL
49neurogenic diabetes insipidus10.0GNRH1, PRL
50pituitary apoplexy10.0GNRH1, PRL

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to hypogonadotropism

Symptoms for Hypogonadotropism

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Drugs & Therapeutics for Hypogonadotropism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hypogonadotropism

Drug clinical trials:

Search ClinicalTrials for Hypogonadotropism

Search NIH Clinical Center for Hypogonadotropism

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Genetic Tests for Hypogonadotropism

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Anatomical Context for Hypogonadotropism

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34MalaCards
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MalaCards organs/tissues related to Hypogonadotropism:

34
Bone, Pituitary, Testes, Eye, Prostate, Testis, Heart, Hypothalamus, Olfactory bulb

Animal Models for Hypogonadotropism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypogonadotropism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9KISS1R, PRL, GNRH1

Publications for Hypogonadotropism

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53PubMed
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Articles related to Hypogonadotropism:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Pubertal induction in adult males with isolated hypogonadotropic hypogonadism using long-acting intramuscular testosterone undecanoate 1-g depot (Nebido(Ar) ). (23383861)
2014
2
Hormone replacement therapy in children with hypogonadotropic hypogonadism: where do we stand? (23807524)
2013
3
Assisted reproductive technique outcomes in hypogonadotropic hypogonadism women. (23793424)
2013
4
Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. (23482592)
2013
5
Multiplex ligation dependent probe amplification analysis of KAL1, GNRH1, GNRHR, PROK2 and PROKR2 in male patients with idiopathic hypogonadotropic hypogonadism]. (24002956)
2013
6
Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism. (22766261)
2012
7
A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain. (23326276)
2012
8
Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism. (22009162)
2012
9
Congenital adrenal hypoplasia and hypogonadotropic hypogonadism: phenotypic variability of the DAX-1 gene R267P mutation. (21925982)
2012
10
Reversible congenital hypogonadotropic hypogonadism in patients with CHD7, FGFR1 or GNRHR mutations. (22724017)
2012
11
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
12
Hypogonadotropic hypogonadism due to GnRH receptor mutation in a sibling. (21717411)
2011
13
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (21856375)
2011
14
Large deletion in the KAL1 gene in two related patients with hypogonadotropic hypogonadism: diagnostic usefulness of cytogenetic and molecular methods. (21717404)
2011
15
Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. (20414046)
2011
16
Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans. (20389089)
2010
17
Kallmann Syndrome and hypogonadotropic Hypogonadism.Concluding remarks. (20389094)
2010
18
Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1. (19489874)
2010
19
Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. (19923792)
2010
20
Neurokinin B and its receptor in hypogonadotropic hypogonadism. (20389091)
2010
21
Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. (19535795)
2009
22
Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. (19820032)
2009
23
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
24
Epidemiology, diagnosis, and treatment of male hypogonadotropic hypogonadism. (19955846)
2009
25
The genetics of idiopathic hypogonadotropic hypogonadism:unraveling the biology of human sexual development. (19396025)
2009
26
Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism. (18946744)
2008
27
Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism. (17140570)
2007
28
Reversal of idiopathic hypogonadotropic hypogonadism. (17761590)
2007
29
Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. (17164310)
2007
30
Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. (17074994)
2006
31
The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action. (16359986)
2005
32
In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. (15728205)
2005
33
Hypogonadotropic hypogonadism due to loss of function of the KiSS1- derived peptide receptor GPR54. (12944565)
2003
34
Inv(10) in a patient with hypogonadotropic hypogonadism. (12773801)
2003
35
Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. (11994356)
2002
36
Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. (12444893)
2002
37
A practical GnRH analogue (triptorelin) stimulation test to distinguish constitutional delay of puberty from hypogonadotropic hypogonadism in prepubertal boys. (11432487)
2001
38
Decrease of serum leptin levels in adult male with idiopathic hypogonadotropic hypogonadism (IHH) treated with pulsatile gonadotropin-releasing hormone (GnRH). (11263471)
2001
39
The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. (10634365)
2000
40
A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism. (10675358)
2000
41
Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. (10456179)
1999
42
Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. (10599708)
1999
43
DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (9195207)
1997
44
The association of premature ejaculation and hypogonadotropic hypogonadism. (9292835)
1997
45
Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (8675564)
1996
46
Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty. (7608268)
1995
47
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. (7990958)
1994
48
Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. (1906410)
1991
49
Hypogonadotropic hypogonadism in mentally retarded adults with microphthalmia and clinical anophthalmia. (2363423)
1990
50
HLA-compatible paternity in two "fertile eunuchs" with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome). (6772660)
1980

Variations for Hypogonadotropism

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Expression for genes affiliated with Hypogonadotropism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadotropism

Search GEO for disease gene expression data for Hypogonadotropism.

Pathways for genes affiliated with Hypogonadotropism

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Hypogonadotropism

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46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1estradiol benzoate469.9PRL, GNRH1
2leuprolide46 62 30 1212.9PRL, GNRH1
3mhpg469.9GNRH1, PRL
4buserelin46 30 1211.9PRL, GNRH1
5leuprolide acetate469.9PRL, GNRH1
6toremifene46 1210.9GNRH1, PRL
7clomiphene citrate469.9GNRH1, PRL
8naltrexone46 30 52 1212.9PRL, GNRH1
9metoclopramide46 52 1211.9GNRH1, PRL
10cabergoline46 30 1211.8GNRH1, PRL
11danazol46 25 1211.8GNRH1, PRL
12cyproteroneacetate469.8PRL, GNRH1
1317-hydroxyprogesterone46 2510.8GNRH1, PRL
14flutamide46 62 1211.8PRL, GNRH1
15bromocriptine46 30 1211.8GNRH1, PRL
16naloxone46 30 52 1212.8PRL, GNRH1
17dehydroepiandrosterone sulfate469.8PRL, GNRH1
18octreotide46 62 30 1212.8PRL, GNRH1
19opiate469.8GNRH1, PRL
20androstenedione46 2510.8PRL, GNRH1
21progestin469.7PRL, GNRH1
22mifepristone46 30 62 1212.7PRL, GNRH1
23estrone46 30 25 1212.7GNRH1, PRL
24cocaine46 1210.7PRL, GNRH1
25dihydrotestosterone46 30 25 1212.6PRL, GNRH1
265-hydroxytryptamine469.6PRL, GNRH1
27thyroxine46 2510.6GNRH1, PRL
28acth469.5PRL, GNRH1
29tamoxifen46 52 30 1212.5PRL, GNRH1
30epinephrine46 25 1211.4PRL, GNRH1
31gnrh469.3KISS1R, PRL, GNRH1
32ribonucleic acid469.2PRL, GNRH1

GO Terms for genes affiliated with Hypogonadotropism

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17Gene Ontology
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Biological processes related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.5PRL, GNRH1

Molecular functions related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5PRL, GNRH1

Products for genes affiliated with Hypogonadotropism

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Hypogonadotropism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet