MCID: HYP064
MIFTS: 48

Hypogonadotropism malady

Summaries for Hypogonadotropism

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MalaCards: Hypogonadotropism is related to hypogonadism and kallmann syndrome. An important gene associated with Hypogonadotropism is KISS1R (KISS1 receptor), and among its related pathways are Tachykinin receptors bind tachykinins and Glycoprotein hormones. The compounds estrogen and danazol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and testes, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hypogonadotropism

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

hypogonadotropism 8 10 44


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Disease Ontology8 DOID:7455

Related Diseases for Hypogonadotropism

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17GeneCards, 18GeneDecks
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Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism31.6KISS1, LHCGR, GNRH1, GNRHR, KAL1, PRL
2kallmann syndrome30.8NR0B1, CHD7, FGFR1, FGF8, KISS1R, PROKR2
3infertility30.4LHCGR, GNRH1, GNRHR, PRL
4amenorrhea30.3GNRH1, PRL
5klinefelter's syndrome30.2GNRH1, GNRHR, KAL1, PRL, PROK2, PROKR2
6charge syndrome30.0CHD7
7male infertility30.0PRL, GNRH1
8azoospermia30.0LHCGR, GNRH1, PRL, NR0B1
9renal agenesis29.7KAL1
10cryptorchidism29.7GNRH1, KAL1, FGFR1
11leukodystrophy29.7POLR3A
12ovarian disease29.7PRL, GNRH1
13premature ovarian failure29.7PRL, GNRH1
14adenocarcinoma29.7FGFR1, GNRHR
15hypogonadotropic hypogonadism 9 with or without anosmia10.3
16hypogonadotropic hypogonadism 17 with or without anosmia10.3
17hypogonadotropic hypogonadism 2 with or without anosmia10.3
18hypogonadotropic hypogonadism 8 with or without anosmia10.3
19isolated gonadotropin-releasing hormone deficiency10.3
20cerebellar ataxia and hypogonadotropic hypogonadism10.3
21eunuchoidism familial hypogonadotropic10.3
22hypogonadotropic hypogonadism 13 with or without anosmia10.3
23hypogonadotropic hypogonadism 15 with or without anosmia10.3
24hypogonadotropic hypogonadism 4 with or without anosmia10.3
25hypogonadotropic hypogonadism 18 with or without anosmia10.3
26hypogonadotropic hypogonadism 7 with or without anosmia10.3
27hypogonadotropic hypogonadism 11 with or without anosmia10.3
28hypogonadotropic hypogonadism 16 with or without anosmia10.3
29hypogonadotropic hypogonadism 20 with or without anosmia10.3
30hypogonadotropic hypogonadism 12 with or without anosmia10.3
31hypogonadotropic hypogonadism 6 with or without anosmia10.3
32hypogonadotropic hypogonadism 14 with or without anosmia10.3
33hypogonadotropic hypogonadism 10 with or without anosmia10.3
34hypogonadotropic hypogonadism 19 with or without anosmia10.3
35hypogonadotropic hypogonadism 3 with or without anosmia10.3
36hypogonadotropic hypogonadism 21 with anosmia10.3
37hypogonadotropic hypogonadism 1 with or without anosmia10.3
38pol iii-related leukodystrophies10.3
39hypogonadotropic hypogonadism 5 with or without anosmia10.3
40obesity10.2
41premature ejaculation10.1
42gonadal dysgenesis10.1
43hyposmia - nasal and ocular hypoplasia - hypogonadotropic hypogonadism10.1
44hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome10.1
45pituitary hypoplasia10.0
46mccune albright syndrome10.0
47choroiditis10.0
48hyperprolactinemia10.0
49panhypopituitarism10.0
50hemochromatosis10.0

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to hypogonadotropism

Clinical Features for Hypogonadotropism

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Drugs & Therapeutics for Hypogonadotropism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypogonadotropism

Drug clinical trials:

Search ClinicalTrials for Hypogonadotropism

Search NIH Clinical Center for Hypogonadotropism

Search CenterWatch for Hypogonadotropism

Genetic Tests for Hypogonadotropism

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Anatomical Context for Hypogonadotropism

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32MalaCards
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MalaCards organs/tissues related to Hypogonadotropism:

32
Pituitary, Bone, Testes, Testis, Prostate, Eye, Ovary, Heart, Olfactory bulb, Hypothalamus

Animal Models for Hypogonadotropism or affiliated genes

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36MGI
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Publications for Hypogonadotropism

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50PubMed
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Articles related to Hypogonadotropism:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
Assessment of deoxyribonucleic acid fragmentation index, testicular volume, semen parameters, and hormone profile in gonadotropin-treated men with hypogonadotropic hypogonadism. (24094652)
2013
2
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. (23643382)
2013
3
Mild adrenal insufficiency due to a NROB1 (DAX1) gene mutation in a boy presenting an association of hypogonadotropic hypogonadism, reduced final height and attention deficit disorder. (24232823)
2013
4
Re: hypogonadotropic hypogonadism in morbidly obese males is reversed after bariatric surgery. (23312190)
2013
5
Anti-pituitary antibodies and hypogonadotropic hypogonadism in type 2 diabetes: in search of a role. (23881971)
2013
6
Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism. (22009162)
2012
7
Mutations in NR5A1 and PIN1 associated with idiopathic hypogonadotropic hypogonadism. (23096908)
2012
8
Molecular defects of the GnRH-receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism. (23155690)
2012
9
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. (21300340)
2011
10
Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. (20414046)
2011
11
Hypogonadotropic hypogonadism in women. (22144224)
2011
12
Isolated hypogonadotropic hypogonadism with SOX2 mutation and anophthalmia/microphthalmia in offspring. (21326281)
2011
13
The role of gene defects underlying isolated hypogonadotropic hypogonadism in patients with constitutional delay of growth and puberty. (21292259)
2011
14
Small supernumerary marker chromosome (sSMC) derived from chromosome 22 in an infertile man with hypogonadotropic hypogonadism. (21465155)
2011
15
Mutation of the KAL1 gene in 30 male patients with idiopathic hypogonadotropic hypogonadism]. (21351529)
2011
16
Update in hyper- and hypogonadotropic amenorrhea. (22058375)
2011
17
Recurrent ectopic pregnancy with heterotopic pregnancy in a patient of hypogonadotropic hypogonadism: a case report. (21682126)
2011
18
Impact of long-term gonadotropin replacement treatment on sleep in men with idiopathic hypogonadotropic hypogonadism. (21143417)
2011
19
Kallmann Syndrome and hypogonadotropic Hypogonadism.Concluding remarks. (20389094)
2010
20
Neurokinin B and its receptor in hypogonadotropic hypogonadism. (20389091)
2010
21
Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. (20382682)
2010
22
The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. (20502053)
2010
23
Rarer syndromes characterized by hypogonadotropic hypogonadism. (20389093)
2010
24
Reversible isolated hypogonadotropic hypogonadism due to mutations in the neurokinin B regulation of gonadotropin-releasing hormone release. (20525912)
2010
25
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. (19567835)
2009
26
X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene. (19773398)
2009
27
Testosterone replacement therapy improves insulin sensitivity and decreases high sensitivity C-reactive protein levels in hypogonadotropic hypogonadal young male patients. (20092788)
2009
28
Prediction of testosterone response to human chorionic gonadotrophin in idiopathic hypogonadotropic hypogonadism patients. (19245075)
2009
29
Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism. (18946744)
2008
30
Moebius-Poland syndrome and hypogonadotropic hypogonadism. (17401577)
2008
31
Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report. (19260388)
2008
32
Reversal of idiopathic hypogonadotropic hypogonadism. (17761590)
2007
33
Two novel GnRHR gene mutations in two siblings with hypogonadotropic hypogonadism. (16868131)
2006
34
Hypogonadotropism with elevated serum testosterone: reversible causes of secondary infertility. (17031381)
2006
35
Cat-eye syndrome with isolated idiopathic hypogonadotropic hypogonadism. (16293919)
2005
36
The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism. (16213849)
2005
37
Molecular analysis of KAL-1, GnRH-R, NELF and EBF2 genes in a series of Kallmann syndrome and normosmic hypogonadotropic hypogonadism patients. (16423815)
2005
38
Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism--diagnostic and therapeutic aspects. (15554892)
2004
39
Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. (11926704)
2002
40
The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. (11788640)
2002
41
Decrease of serum leptin levels in adult male with idiopathic hypogonadotropic hypogonadism (IHH) treated with pulsatile gonadotropin-releasing hormone (GnRH). (11263471)
2001
42
Advances in the molecular genetics of hypogonadotropic hypogonadism. (11220702)
2001
43
Kallmann syndrome (hypogonadotropism-anosmia) and Klippel-Feil anomaly in the same patient. (10649804)
2000
44
A genotypic male with anorchia in conjunction with isolated idiopathic hypogonadotropic hypogonadism. (10573004)
1999
45
Pulsatile intravenous gonadotropin-releasing hormone administration averts fasting-induced hypogonadotropism and hypoandrogenemia in healthy, normal weight men. (9141547)
1997
46
Sporadic heteroplasmic single 5.5 kb mitochondrial DNA deletion associated with cerebellar ataxia, hypogonadotropic hypogonadism, choroidal dystrophy, and mitochondrial respiratory chain complex I deficiency. (9298821)
1997
47
Usefulness of sequential urinary follicle-stimulating hormone and luteinizing hormone measurements in the diagnosis of adolescent hypogonadotropism in males. (8175980)
1994
48
Primary empty sella syndrome and hypogonadotropic hypogonadism in young male patients. (1502422)
1992
49
Congenital cerebellar hypoplasia and hypogonadotropic hypogonadism. (2243234)
1990
50
Pharmacologic hypogonadotropism--an advantage for hMG-induced follicular-maturation and succeeding fertilization. (3096863)
1986

Genetic Variations for Hypogonadotropism

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Expression for genes affiliated with Hypogonadotropism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadotropism

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Pathways for genes affiliated with Hypogonadotropism

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hypogonadotropism

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9TAC3
2danazol44 11 2412.8GNRHR
3degarelix44 28 1112.8GNRH1, GNRHR
4ssr 146977 hydrochloride5910.8TAC3, TACR3
5sb 21879559 2811.8TAC3, TACR3
6histrelin28 4411.8GNRH1, GNRHR
7sb 22220059 2811.8TAC3, TACR3
8abarelix44 28 1112.8GNRH1, GNRHR
9goserelin44 28 1112.7GNRHR, GNRH1, LHCGR
10antarelix44 2811.7GNRH1, GNRHR
11cetrorelix44 28 1112.7LHCGR, GNRH1, GNRHR
12acyline4410.7GNRH1, GNRHR
13ganirelix44 2811.7GNRH1, GNRHR
14leuprolide44 59 28 1113.7GNRH1, GNRHR, PRL
15antide44 2811.7GNRH1, GNRHR
16buserelin44 28 1112.7LHCGR, GNRH1, GNRHR, PRL
17leuprolide acetate4410.7LHCGR, GNRH1, GNRHR, PRL
18d-trp6-lhrh4410.7GNRH1, GNRHR
19flutamide44 59 1112.7LHCGR, GNRH1, PRL
20kassinin28 4411.7TAC3, TACR3
21bromocriptine28 44 1112.6PRL, GNRHR, GNRH1
22ribonucleic acid4410.6LHCGR, GNRH1, GNRHR, PRL, FGFR1
23eledoisin44 2811.6TAC3, TACR3
24senktide44 59 2812.6TAC3, TACR3
25forskolin44 49 1112.6LHCGR, GNRHR, FGF8, TACR3
26septide44 2811.6TAC3, TACR3
27estradiol44 11 2412.6TAC3, PRL, GNRHR, GNRH1, LHCGR
28acth4410.6LHCGR, GNRH1, PRL, NR0B1
29progesterone44 59 28 11 2414.5LHCGR, GNRH1, GNRHR, PRL, NR0B1, FGFR1
30nafarelin44 59 28 1113.5GNRHR, GNRH1
31dopamine44 28 11 2413.5NDUFS4, GNRH1, GNRHR, FGFR1, FGF8, TAC3
32glyceraldehyde 3-phosphate4410.5NDUFS4, FGFR1, KISS1R, KISS1
33steroid4410.5LHCGR, GNRH1, GNRHR, KAL1, PRL, NR0B1
34ptx14410.5GNRH1, GNRHR
35testosterone44 59 11 2413.4LHCGR, NSMF, GNRH1, GNRHR, PRL, NR0B1
36alanine4410.4LHCGR, GNRH1, GNRHR, TACR3, KISS1R, KISS1
37estradiol benzoate4410.4GNRH1, PRL
38mhpg4410.4PRL, GNRH1
39gnrh4410.4KISS1, LHCGR, NSMF, GNRH1, GNRHR, KAL1
40adenylate4410.3LHCGR, GNRH1, GNRHR, FGFR1, TACR3
41calcium44 49 11 2413.3LHCGR, NDUFS4, GNRHR, PROKR2, FGFR1, TAC3
42melatonin44 59 28 11 2414.2PRL, GNRHR, NDUFS4
43progestin4410.0LHCGR, GNRH1, PRL

GO Terms for genes affiliated with Hypogonadotropism

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16Gene Ontology
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Cellular components related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1KISS1, TAC3, FGF8, FGFR1, PROK2, PRL
2DNA-directed RNA polymerase III complexGO:00566610.0POLR3B, POLR3A

Biological processes related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tachykinin receptor signaling pathwayGO:00721710.6TACR3, TAC3
2ovulation cycleGO:04269810.6PRL, GNRH1
3positive regulation of synaptic transmissionGO:05080610.6KISS1, KISS1R
4circadian rhythmGO:00762310.6PROKR2, PROK2, PRL
5female pregnancyGO:00756510.5GNRH1, PRL, TAC3
6cellular response to gonadotropin stimulusGO:07137110.5NSMF, LHCGR
7branching involved in salivary gland morphogenesisGO:06044510.5FGFR1, FGF8
8neuropeptide signaling pathwayGO:00721810.5KISS1R, TAC3, PROK2
9male genitalia developmentGO:03053910.4FGF8, LHCGR
10organ inductionGO:00175910.4FGFR1, FGF8
11G-protein coupled receptor signaling pathwayGO:00718610.4KISS1R, PROK2, GNRHR, LHCGR
12transcription elongation from RNA polymerase III promoterGO:00638510.2POLR3B, POLR3A
13termination of RNA polymerase III transcriptionGO:00638610.0POLR3B, POLR3A

Molecular functions related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase III activityGO:00105610.3POLR3B, POLR3A
2ribonucleoside bindingGO:03254910.0POLR3B, POLR3A

Products for genes affiliated with Hypogonadotropism

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Sources for Hypogonadotropism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet