MCID: HYP064
MIFTS: 38

Hypogonadotropism malady

Summaries for Hypogonadotropism

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33MalaCards
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MalaCards: Hypogonadotropism is related to kallmann syndrome and infertility. An important gene associated with Hypogonadotropism is KISS1R (KISS1 receptor), and among its related pathways are Tachykinin receptors bind tachykinins and Glycoprotein hormones. The compounds estrogen and danazol have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Hypogonadotropism

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

hypogonadotropism 8 10 45


External Ids:

Disease Ontology8 DOID:7455

Related Diseases for Hypogonadotropism

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17GeneCards, 18GeneDecks
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Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1kallmann syndrome30.8NR0B1, CHD7, FGFR1, FGF8, KISS1R, PROKR2
2infertility30.3LHCGR, GNRH1, GNRHR, PRL
3amenorrhea30.3GNRH1, PRL
4klinefelter's syndrome30.3GNRH1, GNRHR, KAL1, PRL, PROK2, PROKR2
5precocious puberty30.1LHCGR, GNRH1, GNRHR, PRL, NR0B1, KISS1
6charge syndrome30.0CHD7
7azoospermia30.0LHCGR, GNRH1, PRL, NR0B1
8renal agenesis29.8KAL1
9cryptorchidism29.7GNRH1, KAL1, FGFR1
10premature ovarian failure29.7PRL, GNRH1
11adenocarcinoma29.7FGFR1, GNRHR
12n syndrome10.4
13hypogonadotropic hypogonadism 9 with or without anosmia10.3
14hypogonadotropic hypogonadism 17 with or without anosmia10.3
15hypogonadotropic hypogonadism 2 with or without anosmia10.3
16hypogonadotropic hypogonadism 8 with or without anosmia10.3
17isolated gonadotropin-releasing hormone deficiency10.3
18cerebellar ataxia and hypogonadotropic hypogonadism10.3
19eunuchoidism familial hypogonadotropic10.3
20hypogonadotropic hypogonadism 13 with or without anosmia10.3
21hypogonadotropic hypogonadism 15 with or without anosmia10.3
22hypogonadotropic hypogonadism 4 with or without anosmia10.3
23hypogonadotropic hypogonadism 18 with or without anosmia10.3
24hypogonadotropic hypogonadism 7 with or without anosmia10.3
25hypogonadotropic hypogonadism 11 with or without anosmia10.3
26hypogonadotropic hypogonadism 16 with or without anosmia10.3
27hypogonadotropic hypogonadism 20 with or without anosmia10.3
28hypogonadotropic hypogonadism 12 with or without anosmia10.3
29hypogonadotropic hypogonadism 6 with or without anosmia10.3
30hypogonadotropic hypogonadism 14 with or without anosmia10.3
31hypogonadotropic hypogonadism 10 with or without anosmia10.3
32hypogonadotropic hypogonadism 19 with or without anosmia10.3
33hypogonadotropic hypogonadism 3 with or without anosmia10.3
34hypogonadotropic hypogonadism 21 with anosmia10.3
35hypogonadotropic hypogonadism 1 with or without anosmia10.3
36pol iii-related leukodystrophies10.3
37hypogonadotropic hypogonadism 5 with or without anosmia10.3
38ataxia10.2
39char syndrome10.2
40ataxia - hypogonadism - choroidal dystrophy10.2
41premature ejaculation10.1
42hyposmia - nasal and ocular hypoplasia - hypogonadotropic hypogonadism10.1
43hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome10.1
44pituitary hypoplasia10.0
45hereditary hemorrhagic telangiectasia10.0
46mccune albright syndrome10.0
47hyperprolactinemia10.0
48panhypopituitarism10.0
49hemochromatosis10.0
50microphthalmia10.0

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to hypogonadotropism

Clinical Features for Hypogonadotropism

Drugs & Therapeutics for Hypogonadotropism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hypogonadotropism

Drug clinical trials:

Search ClinicalTrials for Hypogonadotropism

Search NIH Clinical Center for Hypogonadotropism

Search CenterWatch for Hypogonadotropism

Genetic Tests for Hypogonadotropism

Anatomical Context for Hypogonadotropism

Animal Models for Hypogonadotropism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypogonadotropism

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51PubMed
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Articles related to Hypogonadotropism:

idTitleAuthorsYear
1
Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. (23656588)
2013
2
Hypogonadotropism with elevated serum testosterone: reversible causes of secondary infertility. (17031381)
2006
3
Kallmann syndrome (hypogonadotropism-anosmia) and Klippel-Feil anomaly in the same patient. (10649804)
2000
4
Pulsatile intravenous gonadotropin-releasing hormone administration averts fasting-induced hypogonadotropism and hypoandrogenemia in healthy, normal weight men. (9141547)
1997
5
Usefulness of sequential urinary follicle-stimulating hormone and luteinizing hormone measurements in the diagnosis of adolescent hypogonadotropism in males. (8175980)
1994
6
Adrenal axis and hypogonadotropism in the growth-restricted female lamb. (8312437)
1994
7
Induction of pharmacological hypogonadotropism using gonadotropin-releasing hormone agonists in patients undergoing controlled ovarian stimulation. (2139863)
1990
8
Pharmacologic hypogonadotropism--an advantage for hMG-induced follicular-maturation and succeeding fertilization. (3096863)
1986
9
Gonadotropin and testosterone measurements after estrogen administration to adult men, prepubertal and pubertal boys, and men with hypogonadotropism: evidence for maturation of positive feedback in the male. (1107952)
1976
10
Hypogonadotropism and "empty sella": improvement in 2 cases with clomiphene citrate. (4694501)
1973

Genetic Variations for Hypogonadotropism

Expression for genes affiliated with Hypogonadotropism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypogonadotropism

Search GEO for disease gene expression data for Hypogonadotropism.

Pathways for genes affiliated with Hypogonadotropism

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Hypogonadotropism

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9TAC3
2danazol45 11 2412.8GNRHR
3degarelix45 29 1112.8GNRH1, GNRHR
4ssr 146977 hydrochloride6010.8TAC3, TACR3
5sb 21879560 2911.8TAC3, TACR3
6histrelin29 4511.8GNRH1, GNRHR
7sb 22220060 2911.8TAC3, TACR3
8abarelix45 29 1112.8GNRH1, GNRHR
9goserelin45 29 1112.7GNRHR, GNRH1, LHCGR
10antarelix45 2911.7GNRH1, GNRHR
11cetrorelix45 29 1112.7LHCGR, GNRH1, GNRHR
12acyline4510.7GNRH1, GNRHR
13ganirelix45 2911.7GNRH1, GNRHR
14leuprolide45 60 29 1113.7GNRH1, GNRHR, PRL
15antide45 2911.7GNRH1, GNRHR
16buserelin45 29 1112.7LHCGR, GNRH1, GNRHR, PRL
17leuprolide acetate4510.7LHCGR, GNRH1, GNRHR, PRL
18d-trp6-lhrh4510.7GNRH1, GNRHR
19flutamide45 60 1112.7LHCGR, GNRH1, PRL
20kassinin29 4511.7TAC3, TACR3
21bromocriptine29 45 1112.6PRL, GNRHR, GNRH1
22ribonucleic acid4510.6LHCGR, GNRH1, GNRHR, PRL, FGFR1
23eledoisin45 2911.6TAC3, TACR3
24senktide45 60 2912.6TAC3, TACR3
25forskolin45 50 1112.6LHCGR, GNRHR, FGF8, TACR3
26septide45 2911.6TAC3, TACR3
27estradiol45 11 2412.6TAC3, PRL, GNRHR, GNRH1, LHCGR
28acth4510.6LHCGR, GNRH1, PRL, NR0B1
29progesterone45 60 29 11 2414.5LHCGR, GNRH1, GNRHR, PRL, NR0B1, FGFR1
30nafarelin45 60 29 1113.5GNRHR, GNRH1
31dopamine45 29 11 2413.5NDUFS4, GNRH1, GNRHR, FGFR1, FGF8, TAC3
32glyceraldehyde 3-phosphate4510.5NDUFS4, FGFR1, KISS1R, KISS1
33steroid4510.5LHCGR, GNRH1, GNRHR, KAL1, PRL, NR0B1
34ptx14510.5GNRH1, GNRHR
35testosterone45 60 11 2413.4LHCGR, NSMF, GNRH1, GNRHR, PRL, NR0B1
36alanine4510.4LHCGR, GNRH1, GNRHR, TACR3, KISS1R, KISS1
37estradiol benzoate4510.4GNRH1, PRL
38mhpg4510.4PRL, GNRH1
39gnrh4510.4KISS1, LHCGR, NSMF, GNRH1, GNRHR, KAL1
40adenylate4510.3LHCGR, GNRH1, GNRHR, FGFR1, TACR3
41calcium45 50 11 2413.3LHCGR, NDUFS4, GNRHR, PROKR2, FGFR1, TAC3
42melatonin45 60 29 11 2414.2PRL, GNRHR, NDUFS4
43progestin4510.0LHCGR, GNRH1, PRL

GO Terms for genes affiliated with Hypogonadotropism

Sources:
16Gene Ontology
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Cellular components related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1KISS1, TAC3, FGF8, FGFR1, PROK2, PRL
2DNA-directed RNA polymerase III complexGO:00566610.0POLR3B, POLR3A

Biological processes related to Hypogonadotropism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tachykinin receptor signaling pathwayGO:00721710.6TACR3, TAC3
2ovulation cycleGO:04269810.6PRL, GNRH1
3positive regulation of synaptic transmissionGO:05080610.6KISS1, KISS1R
4circadian rhythmGO:00762310.6PROKR2, PROK2, PRL
5female pregnancyGO:00756510.5GNRH1, PRL, TAC3
6cellular response to gonadotropin stimulusGO:07137110.5NSMF, LHCGR
7branching involved in salivary gland morphogenesisGO:06044510.5FGFR1, FGF8
8neuropeptide signaling pathwayGO:00721810.5KISS1R, TAC3, PROK2
9male genitalia developmentGO:03053910.4FGF8, LHCGR
10organ inductionGO:00175910.4FGFR1, FGF8
11G-protein coupled receptor signaling pathwayGO:00718610.4KISS1R, PROK2, GNRHR, LHCGR
12transcription elongation from RNA polymerase III promoterGO:00638510.2POLR3B, POLR3A
13termination of RNA polymerase III transcriptionGO:00638610.0POLR3B, POLR3A

Molecular functions related to Hypogonadotropism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase III activityGO:00105610.3POLR3B, POLR3A
2ribonucleoside bindingGO:03254910.0POLR3B, POLR3A

Products for genes affiliated with Hypogonadotropism

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Sources for Hypogonadotropism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet