MCID: HYP022
MIFTS: 40

Hypohidrosis malady

Summaries for Hypohidrosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards: Hypohidrosis, also known as oligohidrosis, is related to anhidrosis and ectodermal dysplasia. An important gene associated with Hypohidrosis is EDA (ectodysplasin A). The compounds mucicarmine and glycosphingolipid have been mentioned in the context of this disorder. Affiliated tissues include brain and skin, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Hypohidrosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

hypohidrosis 8 10 45 61
oligohidrosis 8


External Ids:

Disease Ontology8 DOID:11155
MeSH35 D007007
SNOMED-CT57 45004005, 201189007
NCIt40 C34718

Related Diseases for Hypohidrosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1anhidrosis30.3GLA, NTRK1
2ectodermal dysplasia30.3EDAR, EDA, PKP1, TP63
3autonomic neuropathy29.7IKBKAP, NTRK1
4riley-day syndrome29.7IKBKAP, NTRK1
5hypohidrotic ectodermal dysplasia29.7EDAR, EDARADD, EDA
6cholinergic urticaria10.3
7urticaria10.3
8alopecia10.2
9fabry disease10.2
10tooth and nail syndrome10.1
11mycosis fungoides10.1
12n syndrome10.1
13ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.1
14x-linked ichthyosis10.0
15laron syndrome10.0
16horner's syndrome10.0
17basal cell carcinoma10.0
18ameloonychohypohidrotic syndrome10.0
19hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia10.0
20naegeli syndrome10.0
21ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.0
22shaheen syndrome10.0
23ectodermal dysplasia 1, hypohidrotic, x-linked10.0
24epithelial-myoepithelial carcinoma10.0KRT14
25tooth agenesis10.0EDARADD
26neuropathy10.0IKBKAP
27cervical cancer10.0KRT14, TP63
28myoepithelioma10.0KRT14, TP63
29breast fibroadenoma10.0KRT14, TP63
30hypertrophic scars10.0KRT14, TP63
31mucoepidermoid carcinoma10.0TP63, KRT14
32pleomorphic adenoma10.0KRT14, TP63
33adenoid cystic carcinoma10.0TP63, KRT14
34clouston syndrome10.0EDARADD, EDAR
35sensory peripheral neuropathy10.0NTRK1, SPTLC1
36oxyphilic adenoma10.0KRT14, TP63
37squamous cell carcinoma of the head and neck10.0TP63, KRT14, PKP1
38skin benign neoplasm10.0TP63, KRT14
39hereditary sensory neuropathy10.0NTRK1, IKBKAP, SPTLC1
40thymic carcinoma10.0NTRK1, TP63
41papillary carcinoma10.0TP63, KRT14, NTRK1
42lung small cell carcinoma10.0TP63, KRT14, NTRK1
43graft versus host disease9.9
44rothmund-thomson syndrome9.9
45congenital ichthyosiform erythroderma9.9
46acanthosis nigricans9.9
47atopic dermatitis9.9
48miliaria rubra9.9
49arachnoiditis9.9
50lepromatous leprosy9.9

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to hypohidrosis

Clinical Features for Hypohidrosis

Drugs & Therapeutics for Hypohidrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypohidrosis

Search CenterWatch for Hypohidrosis

Genetic Tests for Hypohidrosis

Anatomical Context for Hypohidrosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypohidrosis:

33
Brain, Skin

Animal Models for Hypohidrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypohidrosis

Sources:
51PubMed
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Articles related to Hypohidrosis:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. (23748235)
2014
2
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. (24158451)
2013
3
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. (22963521)
2013
4
Approach to hypohidrosis. (23094789)
2013
5
Horner's syndrome with a sensation of warmth due to hypohidrosis. (23903517)
2013
6
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (23606727)
2013
7
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. (23626547)
2013
8
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. (24426251)
2013
9
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? (23330946)
2013
10
Hypohidrosis and hyperthermia during topiramate treatment in children. (23427516)
2012
11
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? (21392081)
2011
12
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. (21103837)
2011
13
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. (21233059)
2011
14
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. (21079314)
2010
15
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. (19549063)
2010
16
Reversible hypohidrosis with topiramate therapy for chronic migraine. (20236344)
2010
17
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? (20199537)
2010
18
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? (18952524)
2008
19
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. (19050411)
2008
20
Hypohidrosis colocalized with Becker's naevus. (17263814)
2007
21
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. (18032861)
2007
22
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. (17135748)
2006
23
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. (16918633)
2006
24
Hypohidrosis during topiramate treatment: a rare and reversible side effect. (16648001)
2006
25
Successful steroid treatment of acquired idiopathic partial hypohidrosis. (16674791)
2006
26
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. (16363346)
2005
27
Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system. (15369743)
2004
28
Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship ? (14693502)
2003
29
Transient hypohidrosis induced by topiramate. (12823583)
2003
30
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. (11939819)
2002
31
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. (12037443)
2002
32
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. (10691946)
2000
33
Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosis. (11140938)
2000
34
Hypohidrosis in children. (11043004)
1999
35
Acquired generalized hypohidrosis/anhidrosis with subclinical SjAPgren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. (8698925)
1996
36
Ipsilateral hypohidrosis in brain stem infarction. (8418531)
1993
37
Familial simple hypohidrosis with abnormal palmar dermal ridges. (3228139)
1988
38
Polyneuropathy in SjAPgren's syndrome. A case of prevalently autonomic neuropathy with tonic pupil and hypohidrosis. (3056790)
1988
39
Anhidrosis (hypohidrosis) in SjAPgren's syndrome. (3819059)
1987
40
The Bazex syndrome: follicular atrophoderma with multiple basal cell carcinomas, hypotrichosis and hypohidrosis. (7273474)
1981
41
An ectodermal dysplasia syndrome of alopecia, onychodysplasia, hypohidrosis, hyperkeratosis, deafness and other manifestations. (863459)
1977
42
Hyperhidrosis and hypohidrosis. (177967)
1976
43
Hyperpigmentation and hypohidrosis. (The Naegeli-Franceschetti-Jadassohn syndrome): report of a family and review of the literature. (939040)
1976
44
The effect of pretreatment of skin on artificially induced miliaria rubra and hypohidrosis. (4926865)
1971
45
Induced miliaria (prickly heat), post-miliarial hypohidrosis and some potential sequelae. (5811942)
1969
46
The effects of administration of ascorbic acid in experimentally induced miliaria and hypohidrosis in volunteers. (5775074)
1969
47
A comparison of experimentally produced prickly heat and hypohidrosis in Gurkha and British troops. (5787825)
1969
48
Pupillotonia, hyporeflexia, and segmental hypohidrosis: autonomic dysfunction in a child. (5696313)
1968
49
Holmes-Adie syndrome with segmental hypohidrosis. (15088536)
1967
50
Simple methods of testing for hypohidrosis and anhidrosis in leprosy patients in the tropics. (13850409)
1960

Genetic Variations for Hypohidrosis

Expression for genes affiliated with Hypohidrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypohidrosis

Search GEO for disease gene expression data for Hypohidrosis.

Pathways for genes affiliated with Hypohidrosis

Compounds for genes affiliated with Hypohidrosis

Sources:
45Novoseek
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Compounds related to Hypohidrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine459.3TP63, KRT14
2glycosphingolipid459.3GLA, NTRK1
3ceramide459.3SPTLC1, GLA, NTRK1
42-methoxyethanol459.1TP63, KRT14, GLA
5serine458.2PRSS8, NTRK1, GLA, IKBKAP, KRT14, SPTLC1

GO Terms for genes affiliated with Hypohidrosis

Sources:
16Gene Ontology
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Cellular components related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3KRT24, KRT14, PKP1

Biological processes related to Hypohidrosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament bundle assemblyGO:04511010.0KRT14, PKP1
2salivary gland cavitationGO:0606629.9EDA, EDAR
3trachea gland developmentGO:0611539.9EDARADD, EDA
4positive regulation of NF-kappaB import into nucleusGO:0423469.8EDA, EDAR
5pigmentationGO:0434739.7EDA, EDAR
6hair follicle developmentGO:0019429.5EDARADD, EDAR
7positive regulation of NF-kappaB transcription factor activityGO:0510929.3EDA, NTRK1, TAB2
8sympathetic nervous system developmentGO:0484858.7TP63, NTRK1
9odontogenesis of dentin-containing toothGO:0424758.6TP63, EDA, EDARADD, EDAR

Molecular functions related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.0TP63, EDA, PRSS8, PKP1, NTRK1, GLA

Products for genes affiliated with Hypohidrosis

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Sources for Hypohidrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet