Aliases & Classifications for Hypohidrosis

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Aliases & Descriptions for Hypohidrosis:

Name: Hypohidrosis 11 27 50 39 13 68
 
Oligohidrosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:11155
ICD1030 L74.4
SNOMED-CT62 201189007, 45004005
MeSH39 D007007
NCIt45 C34718

Summaries for Hypohidrosis

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Wikipedia:71 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Hypohidrosis, also known as oligohidrosis, is related to ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant and ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant, and has symptoms including flushing, night sweats and rales. An important gene associated with Hypohidrosis is COG6 (Component Of Oligomeric Golgi Complex 6), and among its related pathways is TNF Signaling (sino). Affiliated tissues include skin, eye and testes, and related mouse phenotypes are pigmentation and respiratory system.

Related Diseases for Hypohidrosis

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Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant31.6EDAR, EDARADD
2ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant31.5EDAR, EDARADD
3ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive31.3EDAR, EDARADD
4ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive30.5EDA, EDAR, EDARADD
5shaheen syndrome11.4
6anhidrosis11.2
7fabry disease11.2
8naegeli-franceschetti-jadassohn syndrome11.2
9ichthyosis, congenital, autosomal recessive 1111.1
10ectodermal dysplasia 3, witkop type11.0
11hartnup disorder10.8
12ameloonychohypohidrotic syndrome10.8
13rapp-hodgkin syndrome10.7
14dermatopathia pigmentosa reticularis10.7
15ectodermal dysplasia 1, hypohidrotic, x-linked10.7
16hay-wells syndrome10.7
17lelis syndrome10.7
18ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia10.7
19pigmentary disorder, reticulate, with systemic manifestations10.7
20congenital ichthyosiform erythroderma10.7
21walker dyson syndrome10.2EDAR, EDARADD
22idh3b-related retinitis pigmentosa10.2EDAR, EDARADD
23amelogenesis imperfecta local hypoplastic10.2KRT14, TP63
24bartholin's gland benign neoplasm10.1KRT14, TP63
25vulvar alveolar soft part sarcoma10.1KRT14, TP63
26cholinergic urticaria10.1
27urticaria10.1
28vascular hemostatic disease10.1KRT14, TP63
29water-clear cell adenoma10.1KRT14, TP63
30liver disease10.0KRT14, TP63
31connective tissue benign neoplasm10.0GLA, KRT14
32alopecia9.9
33miliaria9.9
34anal fistula9.9KRT14, TP63
35papillary adenoma9.9GLA, KRT14
36ectodermal dysplasia9.9
37neuroschistosomiasis9.9EDA, EDARADD
38bullous keratopathy9.9KRT14, TP63
39mycosis fungoides9.8
40hypotrichosis9.8
41leprosy9.7
42basal cell carcinoma9.7
43epidermolysis bullosa simplex, dowling-meara type9.7KRT14, TP63
44rothmund-thomson syndrome9.6
45bazex syndrome9.6
46lymphedema9.6
47sialadenitis9.6
48lepromatous leprosy9.6
49miliaria rubra9.6
50respiratory failure9.6

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to hypohidrosis

Symptoms & Phenotypes for Hypohidrosis

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UMLS symptoms related to Hypohidrosis:


flushing, night sweats, rales, general symptom, cold sweat, purulent discharge, single organ dysfunction, yellow complexion, hot flushes, general signs and symptoms nec, local swelling, concomitant disease aggravated, local reaction, peripheral swelling, infusion related reaction, secretion discharge, tissue anoxia, unevaluable event, foaming at mouth, dark circles under eyes, meteoropathy, apparent death, disease prodromal stage, injection related reaction, glassy eye, sensitivity to weather change, fat tissue decreased, autoresuscitation, unmasking of previously unidentified disease

MGI Mouse Phenotypes related to Hypohidrosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.8EDAR, EDARADD, KRT14
2MP:00053888.9ACHE, EDARADD, KRT14, TP63
3MP:00053828.5ACHE, EDAR, EDARADD, KRT14, TP63
4MP:00053787.9ACHE, EDAR, EDARADD, GLA, KRT14, TP63
5MP:00107687.5ACHE, COG6, EDAR, EDARADD, GLA, KRT14
6MP:00053917.1ACHE, EDAR, EDARADD, GLA, KRT14, TP63

Drugs & Therapeutics for Hypohidrosis

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Drugs for Hypohidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nitroprussideapproved6115078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
 
Nitroferricyanide
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
2
Acetylcholineapproved77651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dosing Study of Replagal in Patients With Fabry DiseaseCompletedNCT00068107Phase 2
2An Open-Label Clinical Trial of Replagal Enzyme Therapy in Children Ages 7-17 Years With Fabry DiseaseCompletedNCT00071877Phase 2
3Improving Autonomic Function and Balance in Diabetic NeuropathyRecruitingNCT01864460Phase 2
4A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2
5Gene Therapy for Gaucher's and Fabry Disease Using Viruses and Blood-Forming CellsCompletedNCT00001234Phase 1
6Vasodilation in Patients With Fabry's DiseaseCompletedNCT00001774
7Analysis of the Nervous System in Patients With Fabry's DiseaseCompletedNCT00001491
8Pilot Study of the Effect of Laser on Reversing Chronic Radiation InjuryRecruitingNCT01910818
9Enzyme Replacement Therapy in Fabry DiseaseTerminatedNCT00149318

Search NIH Clinical Center for Hypohidrosis


Cochrane evidence based reviews: hypohidrosis

Genetic Tests for Hypohidrosis

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Genetic tests related to Hypohidrosis:

id Genetic test Affiliating Genes
1 Hypohidrosis27

Anatomical Context for Hypohidrosis

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MalaCards organs/tissues related to Hypohidrosis:

36
Skin, Eye, Testes, Brain, Bone

Publications for Hypohidrosis

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Articles related to Hypohidrosis:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Localized hypohidrosis is an unrecognized sequela of herpes zoster. (27986141)
2017
2
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. (27864842)
2016
3
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. (26402230)
2015
4
Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis. (26452436)
2015
5
First case of congenital idiopathic hypohidrosis in China. (26560219)
2015
6
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. (23748235)
2014
7
Hypohidrosis: an early clue in the diagnosis of Fabry disease. (25546261)
2014
8
Approach to hypohidrosis. (24629071)
2014
9
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. (24158451)
2013
10
Horner's syndrome with a sensation of warmth due to hypohidrosis. (23903517)
2013
11
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. (24184501)
2013
12
Hypohidrosis induced by topiramate in an adult patient. (23773932)
2013
13
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. (24426251)
2013
14
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. (22963521)
2013
15
Approach to hypohidrosis. (23094789)
2013
16
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (23606727)
2013
17
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. (23626547)
2013
18
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? (23330946)
2013
19
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. (23091692)
2012
20
Hypohidrosis and hyperthermia during topiramate treatment in children. (23427516)
2012
21
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. (21103837)
2011
22
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? (21392081)
2011
23
A case of disseminated DLE complicated by atopic dermatitis and SjAPgren's syndrome: link between hypohidrosis and skin manifestations. (20824298)
2011
24
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. (21233059)
2011
25
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. (21079314)
2010
26
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. (19549063)
2010
27
Reversible hypohidrosis with topiramate therapy for chronic migraine. (20236344)
2010
28
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? (20199537)
2010
29
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. (18217788)
2008
30
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. (19050411)
2008
31
Topiramate associated hypohidrosis and hyperthermia. (18367774)
2008
32
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? (18952524)
2008
33
Hypohidrosis colocalized with Becker's naevus. (17263814)
2007
34
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. (18032861)
2007
35
Goosefleshlike lesions and hypohidrosis. (17938352)
2007
36
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. (17135748)
2006
37
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. (16918633)
2006
38
Hypohidrosis during topiramate treatment: a rare and reversible side effect. (16648001)
2006
39
A 52-year-old man with hypohidrosis. (17203598)
2006
40
Successful steroid treatment of acquired idiopathic partial hypohidrosis. (16674791)
2006
41
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. (16363346)
2005
42
Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system. (15369743)
2004
43
Transient hypohidrosis induced by topiramate. (12823583)
2003
44
Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship ? (14693502)
2003
45
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. (12037443)
2002
46
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. (11939819)
2002
47
Hypohidrosis related to the administration of topiramate to children. (11737174)
2001
48
Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. (11069522)
2000
49
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. (10691946)
2000
50
Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosis. (11140938)
2000

Variations for Hypohidrosis

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Expression for genes affiliated with Hypohidrosis

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Search GEO for disease gene expression data for Hypohidrosis.

Pathways for genes affiliated with Hypohidrosis

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Pathways related to Hypohidrosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2EDA, EDAR, EDARADD

GO Terms for genes affiliated with Hypohidrosis

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Cellular components related to Hypohidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical part of cellGO:00451779.6EDA, EDAR

Biological processes related to Hypohidrosis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:004347310.1EDA, EDAR
2positive regulation of NF-kappaB import into nucleusGO:004234610.1EDA, EDAR
3salivary gland cavitationGO:006066210.1EDA, EDAR
4epithelial cell differentiationGO:003085510.0KRT14, TP63
5hair follicle developmentGO:00019429.9EDAR, TP63
6odontogenesis of dentin-containing toothGO:00424759.5EDA, EDAR, TP63
7epidermis developmentGO:00085449.5EDAR, KRT14, TP63
8cell differentiationGO:00301549.2EDA, EDAR, EDARADD, TP63
9tumor necrosis factor-mediated signaling pathwayGO:00332099.2EDA, EDAR, EDARADD

Molecular functions related to Hypohidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hydrolase activityGO:00167879.1ACHE, GLA

Sources for Hypohidrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet