MCID: HYP022
MIFTS: 41

Hypohidrosis malady

Summaries for Hypohidrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards: Hypohidrosis, also known as oligohidrosis, is related to anhidrosis and neuropathy. An important gene associated with Hypohidrosis is EDA (ectodysplasin A). The compounds mucicarmine and glycosphingolipid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Hypohidrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

hypohidrosis 8 10 44 60
oligohidrosis 8


External Ids:

Disease Ontology8 DOID:11155
MeSH34 D007007
SNOMED-CT56 45004005, 201189007
NCIt39 C34718

Related Diseases for Hypohidrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1anhidrosis30.4GLA, NTRK1
2neuropathy29.7IKBKAP
3autonomic neuropathy29.7IKBKAP, NTRK1
4riley-day syndrome29.7IKBKAP, NTRK1
5hypohidrotic ectodermal dysplasia29.7EDAR, EDARADD, EDA
6ectodermal dysplasia29.7EDAR, EDA, PKP1, TP63
7cholinergic urticaria10.3
8urticaria10.3
9alopecia10.2
10miliaria10.2
11fabry disease10.1
12tooth and nail syndrome10.1
13mycosis fungoides10.1
14hypotrichosis10.1
15ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.1
16x-linked ichthyosis10.0
17laron syndrome10.0
18basal cell carcinoma10.0
19leprosy10.0
20ameloonychohypohidrotic syndrome10.0
21hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia10.0
22ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.0
23shaheen syndrome10.0
24ectodermal dysplasia 1, hypohidrotic, x-linked10.0
25epithelial-myoepithelial carcinoma10.0KRT14
26tooth agenesis10.0EDARADD
27myoepithelioma10.0KRT14, TP63
28breast fibroadenoma10.0KRT14, TP63
29hypertrophic scars10.0KRT14, TP63
30mucoepidermoid carcinoma10.0TP63, KRT14
31pleomorphic adenoma10.0KRT14, TP63
32adenoid cystic carcinoma10.0TP63, KRT14
33clouston syndrome10.0EDARADD, EDAR
34sensory peripheral neuropathy10.0NTRK1, SPTLC1
35oxyphilic adenoma10.0KRT14, TP63
36squamous cell carcinoma of the head and neck10.0TP63, KRT14, PKP1
37skin benign neoplasm10.0TP63, KRT14
38hereditary sensory neuropathy10.0NTRK1, IKBKAP, SPTLC1
39thymus cancer10.0NTRK1, TP63
40papillary carcinoma10.0TP63, KRT14, NTRK1
41lung small cell carcinoma10.0TP63, KRT14, NTRK1
42graft versus host disease9.8
43rothmund-thomson syndrome9.8
44congenital ichthyosiform erythroderma9.8
45acanthosis nigricans9.8
46atopic dermatitis9.8
47miliaria rubra9.8
48arachnoiditis9.8
49lepromatous leprosy9.8
50sialadenitis9.8

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to hypohidrosis

Clinical Features for Hypohidrosis

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Drugs & Therapeutics for Hypohidrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Hypohidrosis

Search NIH Clinical Center for Hypohidrosis

Search CenterWatch for Hypohidrosis

Genetic Tests for Hypohidrosis

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Anatomical Context for Hypohidrosis

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32MalaCards
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MalaCards organs/tissues related to Hypohidrosis:

32
Skin, Testes, Bone, Brain

Animal Models for Hypohidrosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypohidrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.4EDAR, EDARADD, EDA, NTRK1, KRT14
2MP:00053818.2TP63, KRT14, IKBKAP, EDA, EDAR
3MP:00053827.7EDAR, EDARADD, EDA, IKBKAP, TP63
4MP:00053917.4EDARADD, EDA, NTRK1, IKBKAP, KRT14, TP63
5MP:00053717.3EDAR, EDARADD, EDA, PRSS8, NTRK1, IKBKAP
6MP:00053877.1EDA, PRSS8, NTRK1, GLA, IKBKAP, TAB2
7MP:00107716.6TP63, EDAR, EDARADD, EDA, PRSS8, NTRK1
8MP:00107686.2EDAR, EDARADD, EDA, PRSS8, NTRK1, IKBKAP

Publications for Hypohidrosis

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50PubMed
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Articles related to Hypohidrosis:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. (24158451)
2013
2
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. (22963521)
2013
3
Approach to hypohidrosis. (23094789)
2013
4
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (23606727)
2013
5
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. (24184501)
2013
6
Hypohidrosis induced by topiramate in an adult patient. (23773932)
2013
7
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. (23626547)
2013
8
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. (24426251)
2013
9
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? (23330946)
2013
10
Hypohidrosis and hyperthermia during topiramate treatment in children. (23427516)
2012
11
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. (23091692)
2012
12
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? (21392081)
2011
13
A case of disseminated DLE complicated by atopic dermatitis and SjAPgren's syndrome: link between hypohidrosis and skin manifestations. (20824298)
2011
14
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. (19549063)
2010
15
Reversible hypohidrosis with topiramate therapy for chronic migraine. (20236344)
2010
16
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? (20199537)
2010
17
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. (18217788)
2008
18
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? (18952524)
2008
19
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. (19050411)
2008
20
Topiramate associated hypohidrosis and hyperthermia. (18367774)
2008
21
Hypohidrosis colocalized with Becker's naevus. (17263814)
2007
22
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. (17135748)
2006
23
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. (16918633)
2006
24
Hypohidrosis during topiramate treatment: a rare and reversible side effect. (16648001)
2006
25
Successful steroid treatment of acquired idiopathic partial hypohidrosis. (16674791)
2006
26
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. (16363346)
2005
27
Transient hypohidrosis induced by topiramate. (12823583)
2003
28
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. (11939819)
2002
29
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. (12037443)
2002
30
Hypohidrosis related to the administration of topiramate to children. (11737174)
2001
31
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. (10691946)
2000
32
Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. (11069522)
2000
33
Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosis. (11140938)
2000
34
Hypohidrosis in children. (11043004)
1999
35
Congenital ichthyosis, follicular atrophoderma, hypotrichosis, and hypohidrosis: a new genodermatosis? (9450882)
1998
36
The ultrastructural characteristics of eccrine sweat glands in a Fabry disease patient with hypohidrosis. (9833977)
1998
37
Acquired generalized hypohidrosis/anhidrosis with subclinical SjAPgren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. (8698925)
1996
38
Ipsilateral hypohidrosis in brain stem infarction. (8418531)
1993
39
Familial simple hypohidrosis with abnormal palmar dermal ridges. (3228139)
1988
40
Polyneuropathy in SjAPgren's syndrome. A case of prevalently autonomic neuropathy with tonic pupil and hypohidrosis. (3056790)
1988
41
Anhidrosis (hypohidrosis) in SjAPgren's syndrome. (3819059)
1987
42
A case of hyperkeratosis palmoplantaris striata combined with pili torti, hypohidrosis, hypodontia and hypacusis. (6217715)
1982
43
Hyperpigmentation and hypohidrosis. (The Naegeli-Franceschetti-Jadassohn syndrome): report of a family and review of the literature. (939040)
1976
44
Hypoplastic enamel, onycholysis, and hypohidrosis inherited as an autosomal dominant trait. A review of ectodermal dysplasia syndromes. (122795)
1975
45
Studies on changes in skin surface bacteria in induced miliaria and associated hypohidrosis. (4117084)
1972
46
Induced miliaria (prickly heat), post-miliarial hypohidrosis and some potential sequelae. (5811942)
1969
47
The effects of administration of ascorbic acid in experimentally induced miliaria and hypohidrosis in volunteers. (5775074)
1969
48
A comparison of experimentally produced prickly heat and hypohidrosis in Gurkha and British troops. (5787825)
1969
49
Pupillotonia, hyporeflexia, and segmental hypohidrosis: autonomic dysfunction in a child. (5696313)
1968
50
Holmes-Adie syndrome with segmental hypohidrosis. (15088536)
1967

Genetic Variations for Hypohidrosis

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Expression for genes affiliated with Hypohidrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypohidrosis

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Pathways for genes affiliated with Hypohidrosis

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Compounds for genes affiliated with Hypohidrosis

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44Novoseek
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Compounds related to Hypohidrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine449.3TP63, KRT14
2glycosphingolipid449.3GLA, NTRK1
3ceramide449.3SPTLC1, GLA, NTRK1
42-methoxyethanol449.1TP63, KRT14, GLA
5serine448.2PRSS8, NTRK1, GLA, IKBKAP, KRT14, SPTLC1

GO Terms for genes affiliated with Hypohidrosis

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16Gene Ontology
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Cellular components related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3KRT24, KRT14, PKP1

Biological processes related to Hypohidrosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament bundle assemblyGO:04511010.0KRT14, PKP1
2salivary gland cavitationGO:0606629.9EDA, EDAR
3trachea gland developmentGO:0611539.9EDARADD, EDA
4positive regulation of NF-kappaB import into nucleusGO:0423469.8EDA, EDAR
5pigmentationGO:0434739.7EDA, EDAR
6hair follicle developmentGO:0019429.5EDARADD, EDAR
7positive regulation of NF-kappaB transcription factor activityGO:0510929.3EDA, NTRK1, TAB2
8sympathetic nervous system developmentGO:0484858.7TP63, NTRK1
9odontogenesis of dentin-containing toothGO:0424758.6TP63, EDA, EDARADD, EDAR

Molecular functions related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.0TP63, EDA, PRSS8, PKP1, NTRK1, GLA

Products for genes affiliated with Hypohidrosis

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Sources for Hypohidrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet