MCID: HYP022
MIFTS: 43

Hypohidrosis malady

Skin diseases category
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Summaries for Hypohidrosis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards: Hypohidrosis, also known as oligohidrosis, is related to anhidrosis and ectodermal dysplasia. An important gene associated with Hypohidrosis is EDA (ectodysplasin A). The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Hypohidrosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hypohidrosis 8 10 45 62
oligohidrosis 8


External Ids:

Disease Ontology8 DOID:11155
NCIt40 C34718
SNOMED-CT58 45004005, 201189007
MeSH35 D007007

Related Diseases for Hypohidrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1anhidrosis30.6GLA
2ectodermal dysplasia30.4EDA, EDAR, TP63
3hypohidrotic ectodermal dysplasia29.9EDAR, EDARADD, EDA
4cholinergic urticaria10.4
5urticaria10.4
6alopecia10.2
7miliaria10.2
8tooth and nail syndrome10.1
9mycosis fungoides10.1
10fabry disease10.1
11hypotrichosis10.1
12ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.1
13tooth agenesis10.1EDARADD
14epithelial-myoepithelial carcinoma10.1KRT14
15clouston syndrome10.1EDAR, EDARADD
16x-linked ichthyosis10.0
17laron syndrome10.0
18basal cell carcinoma10.0
19leprosy10.0
20ameloonychohypohidrotic syndrome10.0
21hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia10.0
22ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.0
23shaheen syndrome10.0
24ectodermal dysplasia 1, hypohidrotic, x-linked10.0
25myoepithelioma10.0KRT14, TP63
26breast fibroadenoma10.0TP63, KRT14
27hypertrophic scars10.0TP63, KRT14
28cervical squamous cell carcinoma10.0TP63, KRT14
29mucoepidermoid carcinoma10.0KRT14, TP63
30pleomorphic adenoma10.0KRT14, TP63
31adenoid cystic carcinoma10.0TP63, KRT14
32oxyphilic adenoma10.0TP63, KRT14
33skin benign neoplasm10.0KRT14, TP63
34transitional cell carcinoma10.0KRT14, TP63
35papilloma10.0TP63, KRT14
36skin disease10.0KRT14, ACHE, TP63
37lung small cell carcinoma10.0KRT14, ACHE, TP63
38papillary carcinoma10.0KRT14, TP63
39graft versus host disease9.9
40rothmund-thomson syndrome9.9
41lepromatous leprosy9.9
42sialadenitis9.9
43riley-day syndrome9.9
44adie syndrome9.9
45horner's syndrome9.9
46acanthosis nigricans9.9
47atopic dermatitis9.9
48miliaria rubra9.9
49arachnoiditis9.9
50autonomic neuropathy9.9

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to hypohidrosis

Symptoms for Hypohidrosis

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Drugs & Therapeutics for Hypohidrosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Hypohidrosis

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Anatomical Context for Hypohidrosis

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33MalaCards
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MalaCards organs/tissues related to Hypohidrosis:

33
Skin, Bone, Brain, Testes

Animal Models for Hypohidrosis or affiliated genes

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Sources:
37MGI
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Publications for Hypohidrosis

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Sources:
52PubMed
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Articles related to Hypohidrosis:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. (24158451)
2013
2
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. (22963521)
2013
3
Approach to hypohidrosis. (23094789)
2013
4
Horner's syndrome with a sensation of warmth due to hypohidrosis. (23903517)
2013
5
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (23606727)
2013
6
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. (24184501)
2013
7
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. (23626547)
2013
8
Hypohidrosis and hyperthermia during topiramate treatment in children. (23427516)
2012
9
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? (21392081)
2011
10
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. (21079314)
2010
11
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. (19549063)
2010
12
Reversible hypohidrosis with topiramate therapy for chronic migraine. (20236344)
2010
13
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. (18217788)
2008
14
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? (18952524)
2008
15
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. (19050411)
2008
16
Topiramate associated hypohidrosis and hyperthermia. (18367774)
2008
17
Hypohidrosis colocalized with Becker's naevus. (17263814)
2007
18
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. (18032861)
2007
19
Goosefleshlike lesions and hypohidrosis. (17938352)
2007
20
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. (17135748)
2006
21
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. (16918633)
2006
22
Hypohidrosis during topiramate treatment: a rare and reversible side effect. (16648001)
2006
23
A 52-year-old man with hypohidrosis. (17203598)
2006
24
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. (16363346)
2005
25
Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system. (15369743)
2004
26
Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship ? (14693502)
2003
27
Transient hypohidrosis induced by topiramate. (12823583)
2003
28
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. (11939819)
2002
29
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. (12037443)
2002
30
Hypohidrosis related to the administration of topiramate to children. (11737174)
2001
31
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. (10691946)
2000
32
Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. (11069522)
2000
33
Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosis. (11140938)
2000
34
Congenital ichthyosis, follicular atrophoderma, hypotrichosis, and hypohidrosis: a new genodermatosis? (9450882)
1998
35
The ultrastructural characteristics of eccrine sweat glands in a Fabry disease patient with hypohidrosis. (9833977)
1998
36
Familial simple hypohidrosis with abnormal palmar dermal ridges. (3228139)
1988
37
Polyneuropathy in SjAPgren's syndrome. A case of prevalently autonomic neuropathy with tonic pupil and hypohidrosis. (3056790)
1988
38
Anhidrosis (hypohidrosis) in SjAPgren's syndrome. (3819059)
1987
39
A case of hyperkeratosis palmoplantaris striata combined with pili torti, hypohidrosis, hypodontia and hypacusis. (6217715)
1982
40
The Bazex syndrome: follicular atrophoderma with multiple basal cell carcinomas, hypotrichosis and hypohidrosis. (7273474)
1981
41
An ectodermal dysplasia syndrome of alopecia, onychodysplasia, hypohidrosis, hyperkeratosis, deafness and other manifestations. (863459)
1977
42
Hyperhidrosis and hypohidrosis. (177967)
1976
43
Hyperpigmentation and hypohidrosis. (The Naegeli-Franceschetti-Jadassohn syndrome): report of a family and review of the literature. (939040)
1976
44
Hypoplastic enamel, onycholysis, and hypohidrosis inherited as an autosomal dominant trait. A review of ectodermal dysplasia syndromes. (122795)
1975
45
The effect of pretreatment of skin on artificially induced miliaria rubra and hypohidrosis. (4926865)
1971
46
Induced miliaria (prickly heat), post-miliarial hypohidrosis and some potential sequelae. (5811942)
1969
47
The effects of administration of ascorbic acid in experimentally induced miliaria and hypohidrosis in volunteers. (5775074)
1969
48
Induced miliaria, postmiliarial hypohidrosis, and some potential sequelae. (4884045)
1969
49
Holmes-Adie syndrome with segmental hypohidrosis. (15088536)
1967
50
Simple methods of testing for hypohidrosis and anhidrosis in leprosy patients in the tropics. (13850409)
1960

Variations for Hypohidrosis

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Expression for genes affiliated with Hypohidrosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypohidrosis

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Pathways for genes affiliated with Hypohidrosis

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Compounds for genes affiliated with Hypohidrosis

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45Novoseek
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Compounds related to Hypohidrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine459.5KRT14, TP63
2hematoxylin459.5KRT14, TP63
32-methoxyethanol459.3KRT14, GLA, TP63
4glutaraldehyde459.0GLA, ACHE
5arginine458.8EDA, TP63, GLA, KRT14

GO Terms for genes affiliated with Hypohidrosis

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16Gene Ontology
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Cellular components related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5KRT24, KRT14
2apical part of cellGO:0451779.5EDAR, EDA

Biological processes related to Hypohidrosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1trachea gland developmentGO:06115310.0EDARADD, EDA
2salivary gland cavitationGO:0606629.9EDAR, EDA
3positive regulation of NF-kappaB import into nucleusGO:0423469.9EDA, EDAR
4pigmentationGO:0434739.8EDAR, EDA
5epidermis developmentGO:0085449.7KRT14, EDAR
6hair follicle developmentGO:0019429.7EDAR, EDARADD
7cell differentiationGO:0301549.2EDA, EDARADD, EDAR
8odontogenesis of dentin-containing toothGO:0424759.1TP63, EDAR, EDARADD, EDA

Molecular functions related to Hypohidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3TAB2, KRT14, GLA, ACHE, TP63, EDAR

Products for genes affiliated with Hypohidrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypohidrosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet