MCID: HYP022
MIFTS: 37

Hypohidrosis malady

Categories: Skin diseases

Aliases & Classifications for Hypohidrosis

Aliases & Descriptions for Hypohidrosis:

Name: Hypohidrosis 12 29 52 42 14 69
Oligohidrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11155
ICD10 33 L74.4
MeSH 42 D007007
NCIt 47 C34718
SNOMED-CT 64 201189007 45004005
UMLS 69 C0020620

Summaries for Hypohidrosis

MalaCards based summary : Hypohidrosis, also known as oligohidrosis, is related to ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant and ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive. An important gene associated with Hypohidrosis is EDA (Ectodysplasin A), and among its related pathways/superpathways is TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Acetylcholine and Nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are mortality/aging and craniofacial

Wikipedia : 71 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

Related Diseases for Hypohidrosis

Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 31.5 EDAR EDARADD
2 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 31.4 EDAR EDARADD
3 lymphedema 29.5 KRT14 TP63
4 congenital insensitivity to pain-hypohidrosis syndrome 11.8
5 shaheen syndrome 11.4
6 anhidrosis 11.2
7 fabry disease 11.2
8 naegeli-franceschetti-jadassohn syndrome 11.2
9 ichthyosis, congenital, autosomal recessive 11 11.1
10 ectodermal dysplasia 11.0
11 ectodermal dysplasia 3, witkop type 11.0
12 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.8
13 ameloonychohypohidrotic syndrome 10.8
14 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.7
15 lelis syndrome 10.7
16 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 10.7
17 rapp-hodgkin syndrome 10.7
18 pigmentary disorder, reticulate, with systemic manifestations 10.7
19 dermatopathia pigmentosa reticularis 10.7
20 ectodermal dysplasia 1, hypohidrotic, x-linked 10.7
21 hay-wells syndrome 10.7
22 prostate cancer 10.1 EDAR EDARADD
23 insr-related hyperinsulinism 10.1 EDAR EDARADD
24 hypoplastic thumbs hydranencephaly 10.1 EDAR EDARADD
25 aml with myelodysplasia-related features 10.1 KRT14 TP63
26 testicular granulosa cell tumor 10.1 KRT14 TP63
27 cholinergic urticaria 10.1
28 urticaria 10.1
29 cauda equina intradural extramedullary astrocytoma 10.1 KRT14 TP63
30 secondary corneal edema 10.1 KRT14 TP63
31 lung combined type small cell carcinoma 10.1 KRT14 TP63
32 cleft palate with ankyloglossia 10.1 EDA EDARADD
33 beriberi 10.1 EDA EDARADD
34 mediastinum angiosarcoma 10.0 KRT14 TP63
35 epidermolysis bullosa simplex-mp 10.0 KRT14 TP63
36 miliaria 9.9
37 alopecia 9.9
38 dementia, familial british 9.9 EDA EDAR EDARADD
39 heavy chain disease 9.9 GLA KRT14
40 scirrhous adenocarcinoma 9.9 KRT14 TP63
41 nanophthalmos 3 9.9 EDA EDAR EDARADD
42 mycosis fungoides 9.8
43 hypotrichosis 9.8
44 ichthyosis 9.8
45 basal cell carcinoma 9.8
46 leprosy 9.8
47 end stage renal failure 9.7 EDA EDAR EDARADD TP63
48 taeniasis 9.7 EDA EDAR EDARADD TP63
49 pili torti 9.6
50 polyneuropathy 9.6

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to Hypohidrosis

Symptoms & Phenotypes for Hypohidrosis

MGI Mouse Phenotypes related to Hypohidrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACHE COG6 EDAR EDARADD GLA KRT14
2 craniofacial MP:0005382 9.65 EDAR EDARADD KRT14 TP63 ACHE
3 reproductive system MP:0005389 9.35 ACHE EDAR EDARADD KRT14 TP63
4 vision/eye MP:0005391 9.1 ACHE EDAR EDARADD GLA KRT14 TP63

Drugs & Therapeutics for Hypohidrosis

Drugs for Hypohidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2
Nitroprusside Approved 15078-28-1 11963622

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dosing Study of Replagal in Patients With Fabry Disease Completed NCT00068107 Phase 2
2 An Open-Label Clinical Trial of Replagal Enzyme Therapy in Children Ages 7-17 Years With Fabry Disease Completed NCT00071877 Phase 2
3 Improving Autonomic Function and Balance in Diabetic Neuropathy Recruiting NCT01864460 Phase 2
4 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2
5 Gene Therapy for Gaucher's and Fabry Disease Using Viruses and Blood-Forming Cells Completed NCT00001234 Phase 1
6 Vasodilation in Patients With Fabry's Disease Completed NCT00001774
7 Analysis of the Nervous System in Patients With Fabry's Disease Completed NCT00001491
8 Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury Recruiting NCT01910818
9 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Hypohidrosis

Cochrane evidence based reviews: hypohidrosis

Genetic Tests for Hypohidrosis

Genetic tests related to Hypohidrosis:

id Genetic test Affiliating Genes
1 Hypohidrosis 29

Anatomical Context for Hypohidrosis

MalaCards organs/tissues related to Hypohidrosis:

39
Skin, Testes, Bone, Brain

Publications for Hypohidrosis

Articles related to Hypohidrosis:

(show top 50) (show all 74)
id Title Authors Year
1
Localized hypohidrosis is an unrecognized sequela of herpes zoster. ( 27986141 )
2017
2
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. ( 27864842 )
2016
3
First case of congenital idiopathic hypohidrosis in China. ( 26560219 )
2015
4
Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis. ( 26452436 )
2015
5
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. ( 26402230 )
2015
6
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
7
Hypohidrosis: an early clue in the diagnosis of Fabry disease. ( 25546261 )
2014
8
Approach to hypohidrosis. ( 24629071 )
2014
9
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. ( 22963521 )
2013
10
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. ( 24158451 )
2013
11
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? ( 23330946 )
2013
12
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. ( 24426251 )
2013
13
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. ( 23606727 )
2013
14
Horner's syndrome with a sensation of warmth due to hypohidrosis. ( 23903517 )
2013
15
Hypohidrosis induced by topiramate in an adult patient. ( 23773932 )
2013
16
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. ( 23626547 )
2013
17
Approach to hypohidrosis. ( 23094789 )
2013
18
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. ( 24184501 )
2013
19
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. ( 23091692 )
2012
20
Hypohidrosis and hyperthermia during topiramate treatment in children. ( 23427516 )
2012
21
A case of disseminated DLE complicated by atopic dermatitis and SjAPgren's syndrome: link between hypohidrosis and skin manifestations. ( 20824298 )
2011
22
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. ( 21233059 )
2011
23
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. ( 21103837 )
2011
24
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? ( 21392081 )
2011
25
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. ( 21079314 )
2010
26
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? ( 20199537 )
2010
27
Reversible hypohidrosis with topiramate therapy for chronic migraine. ( 20236344 )
2010
28
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. ( 19549063 )
2010
29
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. ( 18217788 )
2008
30
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. ( 19050411 )
2008
31
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? ( 18952524 )
2008
32
Topiramate associated hypohidrosis and hyperthermia. ( 18367774 )
2008
33
Hypohidrosis colocalized with Becker's naevus. ( 17263814 )
2007
34
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. ( 18032861 )
2007
35
Goosefleshlike lesions and hypohidrosis. ( 17938352 )
2007
36
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. ( 16918633 )
2006
37
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. ( 17135748 )
2006
38
A 52-year-old man with hypohidrosis. ( 17203598 )
2006
39
Successful steroid treatment of acquired idiopathic partial hypohidrosis. ( 16674791 )
2006
40
Hypohidrosis during topiramate treatment: a rare and reversible side effect. ( 16648001 )
2006
41
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. ( 16363346 )
2005
42
Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system. ( 15369743 )
2004
43
Transient hypohidrosis induced by topiramate. ( 12823583 )
2003
44
Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship ? ( 14693502 )
2003
45
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. ( 12037443 )
2002
46
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. ( 11939819 )
2002
47
Hypohidrosis related to the administration of topiramate to children. ( 11737174 )
2001
48
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. ( 10691946 )
2000
49
Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosis. ( 11140938 )
2000
50
Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. ( 11069522 )
2000

Variations for Hypohidrosis

Expression for Hypohidrosis

Search GEO for disease gene expression data for Hypohidrosis.

Pathways for Hypohidrosis

Pathways related to Hypohidrosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.73 EDA EDAR EDARADD

GO Terms for Hypohidrosis

Biological processes related to Hypohidrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.76 EDA EDAR EDARADD TP63
2 epithelial cell differentiation GO:0030855 9.48 KRT14 TP63
3 hair follicle development GO:0001942 9.43 EDAR TP63
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 EDA EDAR EDARADD
5 pigmentation GO:0043473 9.4 EDA EDAR
6 protein tetramerization GO:0051262 9.37 ACHE TP63
7 epidermis development GO:0008544 9.33 EDAR KRT14 TP63
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.32 EDA EDAR
9 salivary gland cavitation GO:0060662 8.96 EDA EDAR
10 odontogenesis of dentin-containing tooth GO:0042475 8.8 EDA EDAR TP63

Molecular functions related to Hypohidrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ACHE COG6 EDA EDAR EDARADD FAM111B

Sources for Hypohidrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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