Aliases & Classifications for Hypohidrosis

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Aliases & Descriptions for Hypohidrosis:

Name: Hypohidrosis 11 13 25 48 37 66
 
Oligohidrosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:11155
ICD1028 L74.4
SNOMED-CT60 201189007, 45004005
MeSH37 D007007
NCIt43 C34718

Summaries for Hypohidrosis

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Wikipedia:69 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Hypohidrosis, also known as oligohidrosis, is related to ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant and ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant, and has symptoms including flushing, night sweats and rales. An important gene associated with Hypohidrosis is COG6 (Component Of Oligomeric Golgi Complex 6), and among its related pathways is TNF Signaling (sino). Affiliated tissues include skin, eye and testes, and related mouse phenotypes are pigmentation and respiratory system.

Related Diseases for Hypohidrosis

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Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant30.3EDAR, EDARADD
2ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant30.3EDAR, EDARADD
3ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive30.1EDAR, EDARADD
4ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive29.6EDA, EDAR, EDARADD
5shaheen syndrome11.2
6ectodermal dysplasia 3, witkop type11.1
7ichthyosis, congenital, autosomal recessive 1111.0
8hartnup disorder10.9
9ameloonychohypohidrotic syndrome10.9
10anhidrosis10.6
11ectodermal dysplasia10.5
12fabry disease10.5
13naegeli-franceschetti-jadassohn syndrome10.5
14walker dyson syndrome10.3EDAR, EDARADD
15idh3b-related retinitis pigmentosa10.3EDAR, EDARADD
16amelogenesis imperfecta local hypoplastic10.2KRT14, TP63
17cholinergic urticaria10.2
18urticaria10.2
19bartholin's gland benign neoplasm10.2KRT14, TP63
20neuroschistosomiasis10.2EDA, EDARADD
21vulvar alveolar soft part sarcoma10.2KRT14, TP63
22vascular hemostatic disease10.1KRT14, TP63
23water-clear cell adenoma10.1KRT14, TP63
24alopecia10.1
25miliaria10.1
26liver disease10.1KRT14, TP63
27mycosis fungoides10.0
28hypotrichosis10.0
29anal fistula10.0KRT14, TP63
30leprosy9.9
31basal cell carcinoma9.9
32bullous keratopathy9.9KRT14, TP63
33rapp-hodgkin syndrome9.8
34dermatopathia pigmentosa reticularis9.8
35ectodermal dysplasia 1, hypohidrotic, x-linked9.8
36hay-wells syndrome9.8
37lelis syndrome9.8
38ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia9.8
39congenital ichthyosiform erythroderma9.8
40dementia, familial british9.8EDA, EDAR, EDARADD
41connective tissue benign neoplasm9.7GLA, KRT14
42rothmund-thomson syndrome9.7
43bazex syndrome9.7
44lymphedema9.7
45sialadenitis9.7
46lepromatous leprosy9.7
47miliaria rubra9.7
48respiratory failure9.7
49horner's syndrome9.7
50autonomic neuropathy9.7

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to hypohidrosis

Symptoms for Hypohidrosis

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UMLS symptoms related to Hypohidrosis:


flushing, night sweats, rales, general symptom, cold sweat, purulent discharge, single organ dysfunction, yellow complexion, hot flushes, general signs and symptoms nec, local swelling, concomitant disease aggravated, local reaction, peripheral swelling, infusion related reaction, secretion discharge, tissue anoxia, unevaluable event, foaming at mouth, dark circles under eyes, meteoropathy, apparent death, disease prodromal stage, injection related reaction, glassy eye, sensitivity to weather change, fat tissue decreased, autoresuscitation, unmasking of previously unidentified disease

Drugs & Therapeutics for Hypohidrosis

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Drugs for Hypohidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nitroprusside5815078-28-111963622
Synonyms:
13755-38-9 (di-hydrochloride salt, diH20)
14402-89-2 (di-hydrochloride salt)
15078-28-1
C07269
CHEMBL74115
CID11953891
Disodium nitroprusside dihydrate
LS-187044
Nipride
 
Nitroferricyanide
Nitropress
Nitroprusside
Pentacyanidonitrosylferrate(2-)
Sodium Nitroprusside
Sodium nitroferricyanide dihydrate
Sodium nitroprusside dihydrate
Sodium nitroprusside extra pure
UNII-169D1260KM
[Fe(CN)5(NO)](2-)
nitroferricyanide
2
Acetylcholine75251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1An Open-Label Clinical Trial of Replagal Enzyme Therapy in Children Ages 7-17 Years With Fabry DiseaseCompletedNCT00071877Phase 2
2Dosing Study of Replagal in Patients With Fabry DiseaseCompletedNCT00068107Phase 2
3Improving Autonomic Function and Balance in Diabetic NeuropathyRecruitingNCT01864460Phase 2
4A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2
5Gene Therapy for Gaucher's and Fabry Disease Using Viruses and Blood-Forming CellsCompletedNCT00001234Phase 1
6Vasodilation in Patients With Fabry's DiseaseCompletedNCT00001774
7Analysis of the Nervous System in Patients With Fabry's DiseaseCompletedNCT00001491
8Pilot Study of the Effect of Laser on Reversing Chronic Radiation InjuryRecruitingNCT01910818
9Enzyme Replacement Therapy in Fabry DiseaseTerminatedNCT00149318

Search NIH Clinical Center for Hypohidrosis


Cochrane evidence based reviews: hypohidrosis

Genetic Tests for Hypohidrosis

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Genetic tests related to Hypohidrosis:

id Genetic test Affiliating Genes
1 Hypohidrosis25

Anatomical Context for Hypohidrosis

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MalaCards organs/tissues related to Hypohidrosis:

34
Skin, Eye, Testes, Brain, Bone

Animal Models for Hypohidrosis or affiliated genes

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MGI Mouse Phenotypes related to Hypohidrosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6EDAR, EDARADD, KRT14
2MP:00053888.5ACHE, EDARADD, KRT14, TP63
3MP:00053828.3ACHE, EDAR, EDARADD, KRT14, TP63
4MP:00053787.3ACHE, EDAR, EDARADD, GLA, KRT14, TP63
5MP:00053917.0ACHE, EDAR, EDARADD, GLA, KRT14, TP63
6MP:00107686.8ACHE, COG6, EDAR, EDARADD, GLA, KRT14

Publications for Hypohidrosis

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Articles related to Hypohidrosis:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. (26402230)
2015
2
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. (23748235)
2014
3
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. (24158451)
2013
4
Horner's syndrome with a sensation of warmth due to hypohidrosis. (23903517)
2013
5
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. (24184501)
2013
6
Hypohidrosis induced by topiramate in an adult patient. (23773932)
2013
7
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. (24426251)
2013
8
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. (22963521)
2013
9
Approach to hypohidrosis. (23094789)
2013
10
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (23606727)
2013
11
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. (23091692)
2012
12
Hypohidrosis and hyperthermia during topiramate treatment in children. (23427516)
2012
13
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. (21103837)
2011
14
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. (21079314)
2010
15
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. (19549063)
2010
16
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. (18217788)
2008
17
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. (19050411)
2008
18
Topiramate associated hypohidrosis and hyperthermia. (18367774)
2008
19
Hypohidrosis colocalized with Becker's naevus. (17263814)
2007
20
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. (18032861)
2007
21
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. (17135748)
2006
22
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. (16918633)
2006
23
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. (16363346)
2005
24
Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system. (15369743)
2004
25
Transient hypohidrosis induced by topiramate. (12823583)
2003
26
Basaloid follicular hamartoma with eruptive milia and hypohidrosis: is there a pathogenic relationship ? (14693502)
2003
27
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface. (12037443)
2002
28
Alopecia, hypohidrosis, and ulcerations in a man: mycosis fungoides. (11939819)
2002
29
Hypohidrosis related to the administration of topiramate to children. (11737174)
2001
30
Cholinergic urticaria associated with acquired generalized hypohidrosis: report of a case and review of the literature. (11069522)
2000
31
Sporadic Bazex-DuprAc-Christol-like syndrome: early onset basal cell carcinoma, hypohidrosis, hypotrichosis, and prominent milia. (10691946)
2000
32
Hypohidrosis in children. (11043004)
1999
33
The ultrastructural characteristics of eccrine sweat glands in a Fabry disease patient with hypohidrosis. (9833977)
1998
34
Congenital ichthyosis, follicular atrophoderma, hypotrichosis, and hypohidrosis: a new genodermatosis? (9450882)
1998
35
Acquired generalized hypohidrosis/anhidrosis with subclinical SjAPgren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. (8698925)
1996
36
Familial simple hypohidrosis with abnormal palmar dermal ridges. (3228139)
1988
37
Anhidrosis (hypohidrosis) in SjAPgren's syndrome. (3819059)
1987
38
The Bazex syndrome: follicular atrophoderma with multiple basal cell carcinomas, hypotrichosis and hypohidrosis. (7273474)
1981
39
An ectodermal dysplasia syndrome of alopecia, onychodysplasia, hypohidrosis, hyperkeratosis, deafness and other manifestations. (863459)
1977
40
Hyperhidrosis and hypohidrosis. (177967)
1976
41
Hyperpigmentation and hypohidrosis. (The Naegeli-Franceschetti-Jadassohn syndrome): report of a family and review of the literature. (939040)
1976
42
Hypoplastic enamel, onycholysis, and hypohidrosis inherited as an autosomal dominant trait. A review of ectodermal dysplasia syndromes. (122795)
1975
43
The effect of pretreatment of skin on artificially induced miliaria rubra and hypohidrosis. (4926865)
1971
44
A comparison of experimentally produced prickly heat and hypohidrosis in Gurkha and British troops. (5787825)
1969
45
Induced miliaria (prickly heat), post-miliarial hypohidrosis and some potential sequelae. (5811942)
1969
46
The effects of administration of ascorbic acid in experimentally induced miliaria and hypohidrosis in volunteers. (5775074)
1969
47
Induced miliaria, postmiliarial hypohidrosis, and some potential sequelae. (4884045)
1969
48
Pupillotonia, hyporeflexia, and segmental hypohidrosis: autonomic dysfunction in a child. (5696313)
1968
49
Holmes-Adie syndrome with segmental hypohidrosis. (15088536)
1967
50
Simple methods of testing for hypohidrosis and anhidrosis in leprosy patients in the tropics. (13850409)
1960

Variations for Hypohidrosis

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Expression for genes affiliated with Hypohidrosis

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Search GEO for disease gene expression data for Hypohidrosis.

Pathways for genes affiliated with Hypohidrosis

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Pathways related to Hypohidrosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1EDA, EDAR, EDARADD

GO Terms for genes affiliated with Hypohidrosis

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Cellular components related to Hypohidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical part of cellGO:00451779.5EDA, EDAR

Biological processes related to Hypohidrosis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1salivary gland cavitationGO:006066210.1EDA, EDAR
2positive regulation of NF-kappaB import into nucleusGO:004234610.0EDA, EDAR
3tumor necrosis factor-mediated signaling pathwayGO:00332099.6EDA, EDAR, EDARADD
4pigmentationGO:00434739.5EDA, EDAR
5epidermis developmentGO:00085449.5EDAR, KRT14, TP63
6hair follicle developmentGO:00019429.4EDAR, TP63
7epithelial cell differentiationGO:00308559.2KRT14, TP63
8odontogenesis of dentin-containing toothGO:00424759.1EDA, EDAR, TP63
9cell differentiationGO:00301548.7EDA, EDAR, EDARADD, TP63

Molecular functions related to Hypohidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hydrolase activityGO:00167879.0ACHE, GLA

Sources for Hypohidrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet