Aliases & Classifications for Hypohidrosis

MalaCards integrated aliases for Hypohidrosis:

Name: Hypohidrosis 12 28 51 41 14 69
Oligohidrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11155
ICD10 32 L74.4
MeSH 41 D007007
NCIt 46 C34718
SNOMED-CT 64 201189007 45004005
UMLS 69 C0020620

Summaries for Hypohidrosis

MalaCards based summary : Hypohidrosis, also known as oligohidrosis, is related to ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant and ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant. An important gene associated with Hypohidrosis is COG6 (Component Of Oligomeric Golgi Complex 6), and among its related pathways/superpathways is TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Acetylcholine and Nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and pituitary, and related phenotypes are craniofacial and vision/eye

Wikipedia : 72 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

Related Diseases for Hypohidrosis

Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 31.7 EDAR EDARADD
2 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 31.7 EDAR EDARADD
3 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.8 EDA EDAR EDARADD
4 ectodermal dysplasia 30.6 EDA EDAR EDARADD TP63
5 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 30.6 EDA EDAR EDARADD
6 hypotrichosis 29.3 EDA EDAR EDARADD
7 hypohidrosis with abnormal palmar dermal ridges 12.1
8 shaheen syndrome 11.5
9 ichthyosis, congenital, autosomal recessive 11 11.3
10 anhidrosis 11.3
11 fabry disease 11.3
12 naegeli-franceschetti-jadassohn syndrome 11.2
13 witkop syndrome 11.1
14 bazex syndrome 11.1
15 helix syndrome 11.0
16 dermatopathia pigmentosa reticularis 10.9
17 ameloonychohypohidrotic syndrome 10.9
18 ankyloblepharon-ectodermal defects-cleft lip/palate 10.8
19 rapp-hodgkin syndrome 10.8
20 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 10.8
21 pigmentary disorder, reticulate, with systemic manifestations, x-linked 10.8
22 ectodermal dysplasia 1, hypohidrotic, x-linked 10.8
23 limb-mammary syndrome 10.8
24 lelis syndrome 10.8
25 immunodeficiency 10 10.8
26 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.8
27 congenital ichthyosiform erythroderma 10.8
28 ichthyosis follicularis atrichia photophobia syndrome 10.8
29 zlotogora syndrome 10.8
30 hypohidrotic ectodermal dysplasia autosomal recessive 10.2 EDAR EDARADD
31 cholinergic urticaria 10.2
32 urticaria 10.2
33 ameloblastic carcinoma 10.2 KRT14 TP63
34 limbal stem cell deficiency 10.1 KRT14 TP63
35 lipoadenoma 10.1 KRT14 TP63
36 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 10.1 EDAR EDARADD
37 integumentary system benign neoplasm 10.1 GLA KRT14
38 pinguecula 10.0 KRT14 TP63
39 alopecia 10.0
40 miliaria 10.0
41 myoepithelioma 10.0 KRT14 TP63
42 dowling-degos disease 1 9.9
43 mycosis fungoides 9.9
44 pleomorphic adenoma 9.9 KRT14 TP63
45 anodontia 9.9 EDA EDARADD
46 leprosy 3 9.8
47 branchiootic syndrome 1 9.8
48 basal cell carcinoma 1 9.8
49 ichthyosis 9.8
50 basal cell carcinoma 9.8

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to Hypohidrosis

Symptoms & Phenotypes for Hypohidrosis

MGI Mouse Phenotypes related to Hypohidrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 ACHE EDAR EDARADD KRT14 TP63
2 vision/eye MP:0005391 9.1 ACHE EDAR EDARADD GLA KRT14 TP63

Drugs & Therapeutics for Hypohidrosis

Drugs for Hypohidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2
Nitroprusside Approved, Investigational 15078-28-1 11963622

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dosing Study of Replagal in Patients With Fabry Disease Completed NCT00068107 Phase 2 Replagal
2 An Open-Label Clinical Trial of Replagal Enzyme Therapy in Children Ages 7-17 Years With Fabry Disease Completed NCT00071877 Phase 2 Replagal
3 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
4 Gene Therapy for Gaucher's and Fabry Disease Using Viruses and Blood-Forming Cells Completed NCT00001234 Phase 1
5 Vasodilation in Patients With Fabry's Disease Completed NCT00001774
6 Analysis of the Nervous System in Patients With Fabry's Disease Completed NCT00001491
7 Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury Recruiting NCT01910818
8 Improving Autonomic Function and Balance in Diabetic Neuropathy Recruiting NCT01864460
9 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Hypohidrosis

Cochrane evidence based reviews: hypohidrosis

Genetic Tests for Hypohidrosis

Genetic tests related to Hypohidrosis:

# Genetic test Affiliating Genes
1 Hypohidrosis 28

Anatomical Context for Hypohidrosis

MalaCards organs/tissues related to Hypohidrosis:

38
Skin, Testes, Pituitary, Bone, Brain

Publications for Hypohidrosis

Articles related to Hypohidrosis:

(show top 50) (show all 83)
# Title Authors Year
1
Reticulate Hyperpigmentation in a Man With Hypohidrosis and Sinopulmonary Infections. ( 28273282 )
2017
2
Localized hypohidrosis is an unrecognized sequela of herpes zoster. ( 27986141 )
2017
3
Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis. ( 28295553 )
2017
4
Palmoplantar hyperhidrosis: A paradoxical presentation of acquired idiopathic generalized hypohidrosis. ( 28540873 )
2017
5
Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical SjAPgren Syndrome. ( 28448095 )
2017
6
Hypothalamic-pituitary germinoma presenting as generalized hypohidrosis. ( 28202423 )
2017
7
Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus. ( 28342246 )
2017
8
Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies. ( 28977673 )
2017
9
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. ( 28108244 )
2017
10
A Mutation in the Tubulin-Encoding TUBB3 Gene Causes Complex Cortical Malformations and Unilateral Hypohidrosis. ( 28503613 )
2016
11
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. ( 27864842 )
2016
12
Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis. ( 26452436 )
2015
13
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. ( 26402230 )
2015
14
First case of congenital idiopathic hypohidrosis in China. ( 26560219 )
2015
15
Approach to hypohidrosis. ( 24629071 )
2014
16
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
17
Hypohidrosis: an early clue in the diagnosis of Fabry disease. ( 25546261 )
2014
18
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. ( 23626547 )
2013
19
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? ( 23330946 )
2013
20
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. ( 24184501 )
2013
21
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. ( 24158451 )
2013
22
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. ( 24426251 )
2013
23
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. ( 22963521 )
2013
24
Horner's syndrome with a sensation of warmth due to hypohidrosis. ( 23903517 )
2013
25
Hypohidrosis induced by topiramate in an adult patient. ( 23773932 )
2013
26
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. ( 23606727 )
2013
27
Approach to hypohidrosis. ( 23094789 )
2013
28
Hypohidrosis and hyperthermia during topiramate treatment in children. ( 23427516 )
2012
29
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. ( 23091692 )
2012
30
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? ( 21392081 )
2011
31
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. ( 21233059 )
2011
32
A case of disseminated DLE complicated by atopic dermatitis and SjAPgren's syndrome: link between hypohidrosis and skin manifestations. ( 20824298 )
2011
33
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. ( 21103837 )
2011
34
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? ( 20199537 )
2010
35
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. ( 19549063 )
2010
36
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. ( 21079314 )
2010
37
Reversible hypohidrosis with topiramate therapy for chronic migraine. ( 20236344 )
2010
38
Topiramate associated hypohidrosis and hyperthermia. ( 18367774 )
2008
39
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. ( 18217788 )
2008
40
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. ( 19050411 )
2008
41
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? ( 18952524 )
2008
42
Goosefleshlike lesions and hypohidrosis. ( 17938352 )
2007
43
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. ( 18032861 )
2007
44
Hypohidrosis colocalized with Becker's naevus. ( 17263814 )
2007
45
Successful steroid treatment of acquired idiopathic partial hypohidrosis. ( 16674791 )
2006
46
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. ( 17135748 )
2006
47
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. ( 16918633 )
2006
48
A 52-year-old man with hypohidrosis. ( 17203598 )
2006
49
Hypohidrosis during topiramate treatment: a rare and reversible side effect. ( 16648001 )
2006
50
Symptomatic and asymptomatic hypohidrosis in children under topiramate treatment. ( 16363346 )
2005

Variations for Hypohidrosis

Expression for Hypohidrosis

Search GEO for disease gene expression data for Hypohidrosis.

Pathways for Hypohidrosis

Pathways related to Hypohidrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.71 EDA EDAR EDARADD

GO Terms for Hypohidrosis

Biological processes related to Hypohidrosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.76 EDA EDAR EDARADD TP63
2 cell proliferation GO:0008283 9.65 ACHE POLA1 TP63
3 epithelial cell differentiation GO:0030855 9.49 KRT14 TP63
4 pigmentation GO:0043473 9.43 EDA EDAR
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 EDA EDAR EDARADD
6 hair follicle development GO:0001942 9.4 EDAR TP63
7 protein tetramerization GO:0051262 9.37 ACHE TP63
8 epidermis development GO:0008544 9.33 EDAR KRT14 TP63
9 positive regulation of NF-kappaB import into nucleus GO:0042346 9.32 EDA EDAR
10 salivary gland cavitation GO:0060662 8.96 EDA EDAR
11 odontogenesis of dentin-containing tooth GO:0042475 8.8 EDA EDAR TP63

Molecular functions related to Hypohidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ACHE COG6 EDA EDAR EDARADD GLA

Sources for Hypohidrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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