Hypokalemia malady

Wikipedia: Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia...⁴⁴ more...

MalaCards: Hypokalemia is related to gitelman syndrome and hypertension. An important gene associated with Hypokalemia is BSND (Bartter syndrome, infantile, with sensorineural deafness (Barttin)), and among its related pathways are Potassium transporters- inward current and Dopamine-DARPP32 Feedback onto cAMP Pathway. The compounds furosemide and potassium have been mentioned in the context of this disorder. Affiliated tissues include prostate and myeloid, and related mouse phenotypes are cardiovascular system and behavior/neurological.

Aliases & Descriptions:

hypokalemia 6 8 32

Diseases related to hypokalemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 360)

id	Related Disease	Score	Top Affiliating Genes
1	gitelman syndrome	32.4	REN, BSND, KCNJ1, SLC12A1, SLC12A3
2	hypertension	31.3	REN, ACE, ADRB2
3	apparent mineralocorticoid excess syndrome	29.4	REN, HSD11B2
4	hypomagnesemia	28.1	REN, KCNJ10, INS, ALB, ACE, SLC12A1
5	thyrotoxic periodic paralysis	27.9	KCNJ18, ADRB2, CACNA1S
6	hyporeninemic hypoaldosteronism	27.5	REN, INS, ACE
7	liddle syndrome	27.5	REN, CFTR, HSD11B2
8	cushing's syndrome	26.8	HSD11B2, SST, CRH, POMC
9	hyperaldosteronism	26.4	REN, KCNJ1, KCNJ5, INS, HSD11B2, ACE
10	ganglioneuroblastoma	26.1	SST, CRH, TH, NPY
11	paralysis	25.8	PIK3C2A, KCNJ18, KCNJ5, INS, MB, SLC12A3
12	bartter disease	25.4	REN, KCNJ5, MB, SST, CRH, POMC
13	glucose intolerance	24.9	INS, ALB, SST, ACE, NPY
14	aldosteronism	24.7	REN, KCNJ1, KCNJ5, AVPR2, INS, AQP2
15	cystic fibrosis	24.1	REN, KCNJ1, CFTR, INS, AQP2, ALB
16	fibrosis	23.2	REN, KCNJ1, CFTR, INS, AQP2, ALB
17	diarrhea	22.7	REN, CFTR, INS, ALB, SST, ACE
18	peritonitis	22.6	PIK3C2A, REN, INS, AQP2, MB, ALB
19	adenocarcinoma	21.3	PIK3C2A, CFTR, INS, MB, ALB, HSD11B2
20	prostatitis	20.8	PIK3C2A, KCNH2, KCNJ5, CFTR, INS, ALB
21	leukemia	20.3	PIK3C2A, REN, KCNH2, CFTR, INS, MB
22	bartter syndrome, type 2	13.6	REN, KCNJ1
23	low renin hypertension	13.6	REN, HSD11B2
24	pseudohypoaldosteronism type ii	13.6	REN, SLC12A3
25	bartter syndrome antenatal type 2	13.6	REN, KCNJ1, SLC12A1
26	nephrogenic diabetes insipidus	13.6	AVPR2, AQP2
27	renal tubular dysgenesis	13.5	REN, ACE
28	malignant hypertension	13.5	REN, ACE
29	dent disease	13.5	REN, SLC12A1, SLC12A3
30	trichinosis	13.5	PIK3C2A, POMC
31	creatine phosphokinase, elevated serum	13.5	PIK3C2A, MB
32	polyhydramnios	13.5	BSND, KCNJ1, SLC12A1, SLC12A3
33	bartter syndrome type 3	13.4	REN, KCNJ1, SLC12A1, SLC12A3
34	renovascular hypertension	13.4	REN, ACE
35	orthostatic intolerance	13.4	REN, POMC, ADRB2
36	enuresis	13.4	REN, AVPR2, AQP2
37	intermediate coronary syndrome	13.4	PIK3C2A, MB, ACE
38	congenital chloride diarrhea	13.4	REN, SLC26A4
39	inappropriate adh syndrome	13.4	AVPR2, AQP2, POMC
40	chloride diarrhea	13.4	REN, SLC26A4
41	neurogenic diabetes insipidus	13.4	AVPR2, AQP2, POMC
42	neuroleptic malignant syndrome	13.4	PIK3C2A, MB, POMC
43	cor pulmonale	13.4	REN, MB, ACE
44	congenital heart block	13.3	PIK3C2A, KCNH2
45	gas gangrene	13.3	PIK3C2A, MB
46	sudden cardiac death multi-gene panels	13.3	KCNH2, MB, ACE
47	glucocorticoid-remediable aldosteronism	13.3	REN, KCNJ5, POMC
48	conn's syndrome	13.3	REN, KCNJ5, POMC
49	adjustment disorder	13.3	TH, POMC
50	pure autonomic failure	13.3	REN, TH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypokalemia:

²²

MGI Mouse Phenotypes related to hypokalemia:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	ACE, TH, POMC, SLC12A1, SLC12A3, ADRB2
2	behavior/neurological phenotype	MP:0005386	INF	TH, POMC, NPY, SLC26A4, SLC12A1, ADRB2
3	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, SST, CRH, ACE, TH, POMC
4	mortality/aging	MP:0010768	INF	MB, ALB, , ACE, TH, POMC
5	adipose tissue phenotype	MP:0005375	8.0	CACNA1S, ADRB2, NPY, POMC, ACE, INS
6	integument phenotype	MP:0010771	INF	CACNA1S, SLC12A1, POMC, TH, CRH,
7	growth/size phenotype	MP:0005378	INF	SST, CRH, ACE, TH, NPY, SLC12A1
8	renal/urinary system phenotype	MP:0005367	INF	, SLC26A4, SLC12A1, SLC12A3, , INS
9	no phenotypic analysis	MP:0003012	INF	ADRB2, POMC, SST, , INS, KCNK1
10	hematopoietic system phenotype	MP:0005397	INF	SLC12A1, MB, , KCNJ1, BSND
11	normal phenotype	MP:0002873	INF	TH, CRH, SST, , ALB, INS

Articles related to hypokalemia:

(show all 38)

id	Title	Authors	Year	Affiliating Genes
1	TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia. (21653227)	Ma L.... Chen H.	2011	KCNK1
2	Sequential occurrence of life-threatening hypokalemia and rebound hyperkalemia associated with barbiturate coma therapy. (19281748)	Jung J.Y.... Oh K.H.	2009	INS
3	Profound hypokalemia and hypochloremic metabolic alkalosis during thiazide therapy in a child with Pendred syndrome. (18538122)	Pela I.... Bianchi B.	2008	SLC12A3, SLC26A4
4	Severe hypokalemia after holidays return (19055123)	Brasseur A.... Ducobu J.	2008	PIK3C2A
5	Diagnosis of hypokalemia: a problem-solving approach to clinical cases. (19377223)	Assadi F.	2008	REN
6	Gitelman's syndrome (familial hypokalemia-hypomagnese mia). (19582211)	Gjata M.... Gjergji Z.h.	2007	SLC12A3
7	Hypokalemia: a practical approach to diagnosis and its genetic basis. (17584063)	Lin S.H.... Halperin M.L.	2007	REN
8	Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. (17473492)	Yasue H.... Harada E.	2007	MB
9	Approach to hypokalemia. (17297212)	Lim S.	2007	REN
10	A serum potassium level above 10 mmol/l in a patient predisposed to hypokalemia. (16932456)	Phillips D.R.... Karet F.E.	2006	INS
11	Loss of consciousness and hypokalemia in an elderly man with a mutation of the thiazide-sensitive Na-Cl cotransporter gene. (16966826)	Hashida T.... Mori M.	2006	SLC12A3
12	Hypokalemia in Chinese peritoneal dialysis patients: prevalence and prognostic implication. (15983966)	Szeto C.C.... Li P.K.	2005	ALB
13	A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go- related gene (HERG) channels. (16041196)	Lin C.... Somberg J.	2005	KCNH2
14	Gitelman's syndrome--a differential diagnosis in hypokalemia (15114386)	Hovland A.... Leren T.P.	2004	SLC12A3
15	Hypokalemia in children with severe falciparum malari a. (14697114)	Maitland K.... Levin M.	2004	ALB
16	Tubolopaties associated to hypokalemia (15356851)	Capasso G.	2004	BSND
17	Gitelman syndrome. An overlooked disease with chronic hypomagnesemia and hypokalemia in adults (12677988)	Hansen K.W.... Mosekilde L.	2003	SLC12A3
18	Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases. (12381548)	Torpy D.J.... Nieman L.K.	2002	POMC
19	Successful treatment by cyclooxyenase-2 inhibitor of refractory hypokalemia in a patient with Gitelman's syndrome. (12141411)	Mayan H.... Farfel Z.	2002	REN
20	Hypokalemia, metabolic alkalosis, and hypertension: C ushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)	Rickman T.... Okusa M.D.	2001	CRH
21	Gitelman's syndrome (familial hypokalemia-hypomagnesemia). (11281344)	Barakat A.J.... Rennert O.M.	2001	SLC12A3
22	Approach to the patient with hypertension, unexplained hypokalemia, and metabolic alkalosis. (11228201)	Cely C.M.... Contreras G.	2001	REN
23	Older age and in-hospital development of hypokalemia from loop diuretics: results from a multicenter survey. GIFA Investigators. Mul ticenter Italian Pharmacoepidemiologic Study Group. (10811153)	ZuccalA G.... Bernabei R.	2000	ACE
24	Hypokalemia and metabolic alkalosis: algorithms for combined clinical problem solving. (10822791)	Bartholow C.... Rutecki G.W.	2000	REN
25	Cardiac risks of hypokalemia and hypomagnesemia (10894026)	KrAomer B.K.... Endemann D.	2000	ACE
26	Gitelman's syndrome: report of a 19-year old woman with intractable hypomagnesemia and hypokalemia, and a review of the syndrome. (10546515)	Singh P.J.... Zawada E.T.	1999	SLC12A1
27	C-terminal HERG mutations: the role of hypokalemia and a KCNQ1- associated mutation in cardiac event occurrence. (10086971)	Berthet M.... Guicheney P.	1999	KCNH2
28	Hypokalemia and the pathology of ion transport molecules. (9459287)	Antes L.M.... Fernandez P.C.	1998	KCNJ1, SLC12A1
29	Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent. (9048354)	Bates C.M.... Quigley R.	1997	CFTR
30	Hypertension and hypokalemia: unusual syndromes. (9066195)	Cruz D.N.... Perazella M.A.	1997	REN
31	Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism (8949378)	Chamontin B.... Salvador M.	1996	REN
32	Role of epinephrine-induced hypokalemia in the regulation of renin and aldosterone in humans. (8592096)	Kolloch R.E.... Stumpe K.O.	1996	REN
33	Paraneoplastic hypokalemia in acute myeloid leukemia: a case of renin activity in AML blast cells. (8841102)	Wulf G.G.... Hiddemann W.	1996	REN
34	Hypokalemia in the course of a Bartter syndrome (8016500)	BA1tikofer J.... StAoubli M.	1994	REN
35	Multiple-hormone gene expression in ganglioneuroblastoma with watery diarrhea, hypokalemia, and achlorhydria syndrome. (7682155)	Kimura N.... Nagura H.	1993	TH, NPY, SST
36	Unilateral renal artery stenosis seen initially as severe and symptomatic hypokalemia. Pathophysiologic assessment and effects of surgical revascularization. (8442694)	Ruby S.T.... White W.B.	1993	REN
37	Hypokalemia, glucose intolerance, and hyperinsulinemi a during diuretic therapy. (1735589)	Plavinik F.L.... Ribeiro A.B.	1992	INS
38	Hypokalemia before induction of anesthesia and preven tion by beta 2 adrenoceptor antagonism. (1845926)	Kharasch E.D.... Bowdle T.A.	1991	ADRB2

Genes related to hypokalemia according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	BSND	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	11.0	Publications
2	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
3	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11.0	Publications
4	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
5	REN	renin	11.0	Publications
6	CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	11.0
7	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
8	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	11.0	Publications
9	MB	myoglobin	11.0	Publications
10	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
11	POMC	proopiomelanocortin	11.0	Publications
12	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
13	KCNK1	potassium channel, subfamily K, member 1	11.0	Publications
14	SLC26A4	solute carrier family 26, member 4	11.0	Publications
15	NPY	neuropeptide Y	11.0	Publications
16	CRH	corticotropin releasing hormone	11.0	Publications
17	TH	tyrosine hydroxylase	11.0	Publications
18	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
19	SST	somatostatin	11.0	Publications
20	INS	insulin	11.0	Publications
21	ALB	albumin	11.0	Publications

Pathways related to hypokalemia according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Potassium transporters- inward current10	INF	KCNH2, KCNJ1, , , KCNK1
2	Dopamine-DARPP32 Feedback onto cAMP Pathway36	INF	CACNA1S, , , KCNJ1, KCNH2
3	Cation-coupled Chloride cotransporters38	10.1	SLC12A1, SLC12A3
4	MODY (Maturity-Onset Diabetes of Young)36	9.8	KCNK1, CACNA1S
5	Sympathetic Nerve Pathway (Neuroeffector Junction)34	9.8	TH, NPY
6	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	9.5	CRH, POMC
7	Selected targets of CREB110	8.7	CRH, INS, CFTR, REN
8	Selected targets of HNF110	8.7	CFTR, INS, ALB
9	Gastric acid secretion20	INF	KCNJ1, , CFTR, SST
10	Aldosterone-regulated sodium reabsorption20	INF	, INS, KCNJ1
11	Antiarrhythmic Pathway, Pharmacodynamics34	INF	ADRB2, KCNK1, , KCNH2

Compounds related to hypokalemia according to GeneDecks:

(show top 50)    (show all 193)

id	Compound	Score	Top Affiliating Genes
1	furosemide32 42 34 9 18 9	INF	BSND, SLC12A3, , SLC12A1, POMC, ACE
2	potassium32 9 18 9	INF	KCNK1, , , ALB, , ACE
3	sodium32 18	INF	CFTR, PIK3C2A, REN, SLC12A3, CACNA1S, SLC26A4
4	alanine32	INF	, , CFTR, ALB, CRH, TH
5	hydrocortisone32 9 9	INF	, REN, , SST, POMC, INS
6	creatinine32	INF	KCNH2, , REN, MB, , CRH
7	dexamethasone32 42 34 9 9	INF	ADRB2, POMC, TH, CFTR, INS, REN
8	adenylate32	INF	, SST, ADRB2, KCNH2, , CFTR
9	haloperidol32 34 9 9	INF	NPY, POMC, TH, MB, PIK3C2A, REN
10	desmopressin32 42 9 9	INF	, POMC, REN, CFTR, , CRH
11	chloride32	INF	REN, ADRB2, SLC26A4, , , CFTR
12	acth32	INF	CRH, SST, , INS, , REN
13	hydrochlorothiazide32 34 9 18 9	INF	ACE, SLC12A3, REN, , ALB,
14	norepinephrine32 9 18 9	INF	, POMC, PIK3C2A, REN, CFTR,
15	forskolin32 42 9 9	INF	, , SLC12A1, NPY, POMC, TH
16	nitroglycerin32 9 9	12.2	SST
17	metoprolol32 34 9 18 9	13.4	ADRB2, ACE, KCNH2, REN
18	halothane32 9 9	11.1	ALB, ADRB2, PIK3C2A, REN, KCNH2, MB
19	thiazide32	9.1	SLC12A1, ACE, INS, REN, SLC12A3
20	lisinopril32 9 18 9	12.1	NPY, ACE, REN, ALB
21	isoproterenol32 9 9	10.8	KCNH2, CFTR, SST, ADRB2, CRH
22	catecholamine32	8.6	TH, ADRB2, NPY, POMC, PIK3C2A, REN
23	chlorine32 18	9.4	SLC26A4, SLC12A1, CFTR, BSND, ACE, SLC12A3
24	cocaine32 9 9	10.3	TH, ADRB2, NPY, POMC, CRH, MB
25	verapamil32 34 9 18 9	12.3	REN, KCNH2, CFTR, CRH, ACE, TH
26	gnrh32	8.1	ADRB2, POMC, INS, CRH, CFTR, NPY
27	5-hydroxytryptamine32	7.8	NPY, POMC, ADRB2, CRH, CFTR, TH
28	thyroxine32 18	7.8	REN, PIK3C2A, ALB, MB, SST, CRH
29	sodium nitroprusside32	INF	MB, , REN, PIK3C2A, NPY, SST
30	testosterone32 9 18 9	INF	TH, CRH, SST, MB, CFTR,
31	dopamine32 9 18 9	INF	REN, TH, ADRB2, CRH, SST, MB
32	corticosterone32 18	INF	TH, NPY, , REN, CRH, POMC
33	nacl32	INF	ADRB2, REN, BSND, KCNJ1, , SLC26A4
34	glutamate32	INF	INS, CFTR, , TH, SST
35	acetylcholine32 9 18 9	INF	PIK3C2A, , TH, MB, POMC, CRH
36	lactate32	INF	TH, SST, INS, , NPY, MB
37	glucose32	INF
38	glibenclamide32 34	INF	, ADRB2, CRH, INS, CFTR
39	pge232	INF	REN, ADRB2, SLC12A1, POMC, CRH, SST
40	arginine32	INF	INS, MB, KCNJ1, , REN, PIK3C2A
41	tolbutamide32 34 9 9	INF	CFTR, KCNJ1, , INS, SST
42	spironolactone32 42 34 9 9	INF	, CRH, POMC, KCNH2, ALB, ACE
43	aspartate32	INF	CFTR, , MB, PIK3C2A, ALB, TH
44	nifedipine32 9 9	INF	CRH, CACNA1S, ACE, NPY, SST, REN
45	diazoxide32 42 9 9	INF	SST, SLC12A3, , INS, CFTR
46	naloxone32 34 9 9	INF	, POMC, CRH, SST, ADRB2
47	terlipressin32 9 9	INF	SST, ALB, , REN
48	epinephrine32 9 18 9	INF	CFTR, INS, , MB, SST, CRH
49	glycerol32 9 18 9	INF	MB, PIK3C2A, CFTR, INS, , ADRB2
50	prednisolone32 9 9	INF	PIK3C2A, NPY, POMC, , ALB, MB

Cellular components related to hypokalemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apical plasma membrane	GO:016324	INF	, CFTR, , SLC26A4, SLC12A3, ADRB2
2	basolateral plasma membrane	GO:016323	INF	BSND, , CFTR,
3	plasma membrane	GO:005886	INF	ACE, SLC26A4, SLC12A1, SLC12A3, ADRB2, CACNA1S
4	extracellular space	GO:005615	6.6	NPY, POMC, ACE, CRH, SST, ALB
5	voltage-gated potassium channel complex	GO:008076	INF	KCNK1, , KCNJ1, KCNH2

Biological processes related to hypokalemia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission	GO:007268	INF	NPY, CRH, SST, KCNK1, ,
2	transmembrane transport	GO:055085	INF	SLC12A3, SLC12A1, SLC26A4, ALB, ,
3	potassium ion transport	GO:006813	INF	KCNH2, SLC12A1, KCNK1, , , KCNJ1
4	excretion	GO:007588	INF	, , KCNJ1
5	regulation of blood pressure	GO:008217	9.7	REN, ACE, POMC
6	induction of apoptosis by hormones	GO:008628	9.4	SST, CRH
7	negative regulation of urine volume	GO:035811	INF	, ADRB2

Molecular functions related to hypokalemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	8.3	INS, SST, CRH, POMC
2	inward rectifier potassium channel activity	GO:005242	INF	KCNH2, KCNJ1, , KCNK1