MCID: HYP005
MIFTS: 50

Hypokalemia malady

Metabolic diseases category
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Summaries for Hypokalemia

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Wikipedia:65 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards based summary: Hypokalemia is related to hypertension and hyperaldosteronism. An important gene associated with Hypokalemia is BSND (Bartter syndrome, infantile, with sensorineural deafness (Barttin)), and among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds bendroflumethiazide and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Hypokalemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 25ICD10
See all sources

Hypokalemia, Aliases & Descriptions:

Name: Hypokalemia 8 10 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:4500
NCIt39 C34939
ICD1025 E87.6

Related Diseases for Hypokalemia

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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.0SLC12A3, REN
2hyperaldosteronism30.3KCNJ1, CLCNKB, REN, SLC12A3
3congestive heart failure29.9REN, AQP2
4nephrocalcinosis29.9SLC12A1, CLCNKB, KCNJ1
5metabolic acidosis29.7SLC12A1, REN, AQP2
6gitelman syndrome29.5BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
7essential hypertension29.4SLC12A3, SLC12A1, REN, AQP2
8bartter disease28.9BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
9diarrhea10.5
10hepatorenal syndrome10.3REN
11diabetes insipidus10.3AQP2
12thyrotoxic periodic paralysis10.3
13hypophosphatemia10.3
14cushing's syndrome10.3
15adenoma10.3
16leukemia10.3
17peritonitis10.3
18diabetic ketoacidosis10.2
19brugada syndrome10.2
20pheochromocytoma10.2
21sensorineural hearing loss10.2BSND, CLCNKB
22hypokalemic periodic paralysis10.2
23quadriplegia10.2
24hyperglycemia10.2
25wdha syndrome10.2
26pseudohypoaldosteronism type ii10.2REN, SLC12A3
27celiac disease10.1
28islet cell tumor10.1
29apparent mineralocorticoid excess syndrome10.1
30vipoma10.1
31hypoglycemia10.1
32conn's syndrome10.1
33adrenal adenoma10.1
34kidney disease10.1
35long qt syndrome10.1
36lung cancer10.1
37respiratory failure10.1
38hypertensive hypokalemia familial10.1
39hypoaldosteronism10.1
40head injury10.1
41stroke, ischemic10.1SLC12A3, REN
42primary hyperoxaluria10.1SLC12A3, REN
43acute myeloid leukemia10.0
44diabetes mellitus10.0
45glomerulonephritis10.0
46hepatitis10.0
47liddle syndrome10.0
48nephrolithiasis10.0
49renal tubular acidosis10.0
50hypercalcemia10.0

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Symptoms for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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Drug clinical trials:

Search ClinicalTrials for Hypokalemia

Search NIH Clinical Center for Hypokalemia

Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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MalaCards organs/tissues related to Hypokalemia:

32
Heart, Kidney, Liver, Lung, Brain, Pancreas, Thyroid, Myeloid, Eye, Cortex, Spinal cord, Skeletal muscle, Colon, Breast, Prostate, Testes, B cells, Endothelial, Pituitary

Animal Models for Hypokalemia or affiliated genes

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MGI Mouse Phenotypes related to Hypokalemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.7BSND, SLC12A3, SLC12A1, REN, KCNJ1
2MP:00053977.6REN, AQP2, KCNJ1, SLC12A1, BSND
3MP:00107687.6BSND, KCNJ1, AQP2, REN, SLC12A1
4MP:00053867.5SLC12A1, REN, AQP2, KCNJ1, BSND
5MP:00053787.3SLC12A1, REN, AQP2, KCNJ1, BSND
6MP:00053677.3BSND, AQP2, REN, SLC12A1, KCNJ1, SLC12A3
7MP:00053767.3SLC12A1, REN, KCNJ1, SLC12A3, AQP2, BSND

Publications for Hypokalemia

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Articles related to Hypokalemia:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Possible brugada phenocopy induced by hypokalemia in a patient with congenital hypokalemic periodic paralysis. (24652091)
2014
2
Etiology and symptoms of severe hypokalemia in emergency department patients. (23839104)
2014
3
Hypokalemia and hypomagnesaemia related to levetiracetam use. (24906211)
2014
4
Hypokalemia and hyperkalemia in infants and children: pathophysiology and treatment. (24139581)
2013
5
Thyrotoxic periodic paralysis: correct hypokalemia with caution. (23849367)
2013
6
Severe Hypokalemia in a Patient With Subarachnoid Hemorrhage. (23972266)
2013
7
Furosemide-induced severe hypokalemia with rhabdomyolysis without cardiac arrest. (23834955)
2013
8
It is never too late for a genetic disease: a case of a 79-year-old man with persistent hypokalemia. (23475471)
2013
9
Central pontine and extrapontine myelinolysis secondary to fast correction of severe hyponatremia and hypokalemia in an alcoholic patient. (23180443)
2012
10
Polycystic kidney disease presenting with hypertension and hypokalemia. (21962616)
2012
11
Early recognition of reverse pseudohyperkalemia in heparin plasma samples during leukemic hyperleukocytosis can prevent iatrogenic hypokalemia. (22877885)
2012
12
Hypokalemia following polyethylene glycol-based bowel preparation for colonoscopy in older hospitalized patients with significant comorbidities. (20124467)
2010
13
A practical approach to genetic hypokalemia. (21468196)
2010
14
A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. (20338465)
2010
15
Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer. (19760217)
2010
16
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
17
Quiz Page September 2009. Long-standing high-renin hypertension and hypokalemia: renin-secreting tumor of the juxtaglomerular apparatus. (19700057)
2009
18
Primary aldosteronism associated with severe rhabdomyolysis due to profound hypokalemia. (19218772)
2009
19
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
20
Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia. (18808610)
2008
21
Hypokalemia: a quick reference. (18402873)
2008
22
Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula. (17891350)
2007
23
Hypokalemia: a practical approach to diagnosis and its genetic basis. (17584063)
2007
24
Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. (16871112)
2006
25
Ventricular fibrillation due to severe hypokalemia induced by steroid treatment in a patient with thyrotoxic periodic paralysis. (16467598)
2006
26
A serum potassium level above 10 mmol/l in a patient predisposed to hypokalemia. (16932456)
2006
27
Atrial fibrillation and recurrent ventricular fibrillation during hypokalemia in Brugada syndrome. (16403168)
2005
28
Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. (12520160)
2003
29
Ethnicity and unprovoked hypokalemia in the ARIC Study. (12118918)
2002
30
Disorders of potassium homeostasis. Hypokalemia and hyperkalemia. (12053834)
2002
31
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
32
Torsade de pointes with a normal QT interval associated with hypokalemia: a case report. (11502056)
2001
33
Evaluation of different nebulized bronchodilators on clinical efficacy and hypokalemia in asthmatic children. (11729705)
2001
34
The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis. (11045278)
2000
35
Saline-resistant metabolic alkalosis, severe hypokalemia and hypertension in a 74-year-old woman. (10661485)
2000
36
Adult celiac disease presented with celiac crisis: severe diarrhea, hypokalemia, and acidosis. (10777199)
2000
37
Hypokalemia-induced ultrastructural, histochemical and connexin-43 alterations resulting in atrial and ventricular fibrillations. (10707826)
1999
38
The effect of varying molar ratios of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. (9824785)
1998
39
Hypokalemia. (9700180)
1998
40
The effects of hypokalemia on the heart. (9231617)
1997
41
The influence of chronic hypokalemia on myocardial adrenergic receptor densities: enhanced sensitivity to epinephrine-induced arrhythmias. (9085948)
1997
42
Hypokalemia in a patient with pheochromocytoma. (15251511)
1996
43
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
44
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
45
ECG of the month. On a lower level. Hypokalemia. (1377739)
1992
46
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
47
Zollinger-Ellison syndrome: intermittent diarrhea, relentless hypokalemia, and hypergastrinemia. (7328691)
1981
48
Hypertension, hypokalemia and hypoaldosteronism with suppressed renin: a clinical study of a patient with Liddle's syndrome. (6273144)
1981
49
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
50
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. (4344758)
1972

Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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Expression patterns in normal tissues for genes affiliated with Hypokalemia

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Pathways for genes affiliated with Hypokalemia

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Compounds for genes affiliated with Hypokalemia

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Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1bendroflumethiazide44 1110.8SLC12A3, REN
2desmopressin44 61 28 1112.7REN, AQP2
3diazoxide44 61 28 1112.7SLC12A3, KCNJ1
4lithium44 50 24 1112.7AQP2, REN
5haloperidol44 50 28 2 1113.6AQP2, REN
6hydrocortisone44 2 61 1112.6REN, AQP2
7biotin44 24 1111.5AQP2, KCNJ1
8bumetanide44 61 28 50 1113.5SLC12A3, SLC12A1
9potassium chloride44 1110.4REN, SLC12A1
10prostaglandin449.4REN, AQP2
11urea44 24 1111.2AQP2, SLC12A1
12thiazide449.0SLC12A1, SLC12A3, REN
13arginine448.9AQP2, KCNJ1, REN
14forskolin44 50 1110.9REN, AQP2, SLC12A1
15pge2448.8REN, SLC12A1, AQP2
16chlorine44 249.8BSND, SLC12A3, CLCNKB, SLC12A1
17hydrochlorothiazide44 28 50 24 1112.7REN, KCNJ1, AQP2, SLC12A3
18nitric oxide44 24 1110.6SLC12A1, AQP2, REN
19threonine448.6SLC12A3, SLC12A1, AQP2
20alanine448.6SLC12A3, AQP2, KCNJ1
21magnesium44 24 1110.4CLCNKB, KCNJ1, AQP2, SLC12A1
22furosemide44 61 28 50 24 1113.1BSND, REN, AQP2, SLC12A1, SLC12A3
23calcium44 50 24 1110.7CLCNKB, SLC12A1, SLC12A3, BSND, AQP2, REN
24chloride447.1SLC12A1, AQP2, REN, CLCNKB, KCNJ1, BSND
25nacl447.1AQP2, REN, SLC12A1, SLC12A3, KCNJ1, BSND
26potassium44 24 119.1CLCNKB, SLC12A1, SLC12A3, KCNJ1, AQP2, REN
27sodium44 248.1KCNJ1, SLC12A3, SLC12A1, AQP2, CLCNKB, BSND

GO Terms for genes affiliated with Hypokalemia

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Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.6AQP2, BSND
2membraneGO:0160208.4SLC12A3, SLC12A1, AQP2
3plasma membraneGO:0058866.6SLC12A3, BSND, KCNJ1, CLCNKB, AQP2, REN

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chloride transportGO:0068219.3SLC12A3, SLC12A1
2sodium ion transportGO:0068149.3SLC12A3, SLC12A1
3kidney developmentGO:0018229.2REN, KCNJ1
4ion transportGO:0068119.2SLC12A3, SLC12A1
5excretionGO:0075889.1KCNJ1, CLCNKB, AQP2
6response to lipopolysaccharideGO:0324969.1REN, AQP2
7ion transmembrane transportGO:0342209.0SLC12A1, CLCNKB, BSND
8potassium ion transportGO:0068139.0KCNJ1, SLC12A1
9chloride transmembrane transportGO:19024769.0SLC12A3, SLC12A1, BSND
10transportGO:0068108.9CLCNKB, SLC12A1, SLC12A3
11transmembrane transportGO:0550858.1SLC12A3, SLC12A1, AQP2, CLCNKB, BSND

Products for genes affiliated with Hypokalemia

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Sources for Hypokalemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet