Aliases & Classifications for Hypokalemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 38NCIt, 60UMLS, 25ICD10
See all sources

Hypokalemia, Aliases & Descriptions:

Name: Hypokalemia 9 11 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:4500
NCIt38 C34939
ICD1025 E87.6

Summaries for Hypokalemia

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Wikipedia:63 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards based summary: Hypokalemia is related to kidney disease and hyperaldosteronism. An important gene associated with Hypokalemia is BSND (Bartter syndrome, infantile, with sensorineural deafness (Barttin)), and among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds bendroflumethiazide and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Related Diseases for Hypokalemia

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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1kidney disease30.3SLC12A3, REN
2hyperaldosteronism30.2KCNJ1, CLCNKB, REN, SLC12A3
3congestive heart failure29.9REN, AQP2
4nephrocalcinosis29.8SLC12A1, CLCNKB, KCNJ1
5metabolic acidosis29.7SLC12A1, REN, AQP2
6gitelman syndrome29.5BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
7bartter syndrome, type 328.9KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
8bartter disease28.9BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
9diarrhea10.5
10cushing's syndrome10.4
11hepatorenal syndrome10.3REN
12diabetes insipidus10.3AQP2
13thyrotoxic periodic paralysis10.3
14hypophosphatemia10.3
15adenoma10.3
16leukemia10.3
17diabetic ketoacidosis10.3
18peritonitis10.3
19pheochromocytoma10.2
20vipoma10.2
21brugada syndrome10.2
22sensorineural hearing loss10.2BSND, CLCNKB
23liddle syndrome10.2
24apparent mineralocorticoid excess10.2
25hepatitis10.2
26quadriplegia10.2
27atrial fibrillation10.2
28hyperglycemia10.2
29hypertensive hypokalemia familial10.2
30pseudohypoaldosteronism, type iie10.2REN, SLC12A3
31thyrotoxic periodic paralysis 110.1
32lung cancer10.1
33celiac disease10.1
34islet cell tumor10.1
35hypoglycemia10.1
36conn's syndrome10.1
37adrenal adenoma10.1
38long qt syndrome10.1
39respiratory failure10.1
40hypoaldosteronism10.1
41head injury10.1
42stroke, ischemic10.1SLC12A3, REN
43diarrhea 1, secretory chloride, congenital10.0
44ehlers-danlos syndrome, type iv10.0
45brain injury10.0
46glomerulonephritis10.0
47nephrolithiasis10.0
48renal tubular acidosis10.0
49traumatic brain injury10.0
50oculocerebrorenal syndrome10.0

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Symptoms for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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Drug clinical trials:

Search ClinicalTrials for Hypokalemia

Search NIH Clinical Center for Hypokalemia

Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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MalaCards organs/tissues related to Hypokalemia:

31
Heart, Kidney, Brain, Liver, Lung, Pancreas, Thyroid, Myeloid, Eye, Cortex, Spinal cord, Skeletal muscle, Colon, Breast, Prostate, Testes, B cells, Endothelial, Pituitary

Animal Models for Hypokalemia or affiliated genes

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MGI Mouse Phenotypes related to Hypokalemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.7BSND, KCNJ1, REN, SLC12A1, SLC12A3
2MP:00053977.6BSND, KCNJ1, AQP2, REN, SLC12A1
3MP:00107687.6SLC12A1, REN, AQP2, KCNJ1, BSND
4MP:00053867.5SLC12A1, REN, AQP2, KCNJ1, BSND
5MP:00053787.3BSND, KCNJ1, AQP2, REN, SLC12A1
6MP:00053677.3SLC12A3, SLC12A1, REN, AQP2, KCNJ1, BSND
7MP:00053767.3BSND, KCNJ1, AQP2, REN, SLC12A1, SLC12A3

Publications for Hypokalemia

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Articles related to Hypokalemia:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Paradoxical hypokalemia: where has all the potassium gone? (25446305)
2015
2
An 18-year-old female with weight loss and hypokalemia. (25658211)
2015
3
Possible brugada phenocopy induced by hypokalemia in a patient with congenital hypokalemic periodic paralysis. (24652091)
2014
4
Etiology and symptoms of severe hypokalemia in emergency department patients. (23839104)
2014
5
Hypokalemia and hypomagnesaemia related to levetiracetam use. (24906211)
2014
6
Hypokalemia and hyperkalemia in infants and children: pathophysiology and treatment. (24139581)
2013
7
Thyrotoxic periodic paralysis: correct hypokalemia with caution. (23849367)
2013
8
Severe Hypokalemia in a Patient With Subarachnoid Hemorrhage. (23972266)
2013
9
Furosemide-induced severe hypokalemia with rhabdomyolysis without cardiac arrest. (23834955)
2013
10
It is never too late for a genetic disease: a case of a 79-year-old man with persistent hypokalemia. (23475471)
2013
11
Central pontine and extrapontine myelinolysis secondary to fast correction of severe hyponatremia and hypokalemia in an alcoholic patient. (23180443)
2012
12
Polycystic kidney disease presenting with hypertension and hypokalemia. (21962616)
2012
13
Hypokalemia following polyethylene glycol-based bowel preparation for colonoscopy in older hospitalized patients with significant comorbidities. (20124467)
2010
14
A practical approach to genetic hypokalemia. (21468196)
2010
15
A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. (20338465)
2010
16
Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer. (19760217)
2010
17
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
18
Quiz Page September 2009. Long-standing high-renin hypertension and hypokalemia: renin-secreting tumor of the juxtaglomerular apparatus. (19700057)
2009
19
Primary aldosteronism associated with severe rhabdomyolysis due to profound hypokalemia. (19218772)
2009
20
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
21
Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia. (18808610)
2008
22
Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula. (17891350)
2007
23
Hypokalemia: a practical approach to diagnosis and its genetic basis. (17584063)
2007
24
Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. (16871112)
2006
25
Ventricular fibrillation due to severe hypokalemia induced by steroid treatment in a patient with thyrotoxic periodic paralysis. (16467598)
2006
26
A serum potassium level above 10 mmol/l in a patient predisposed to hypokalemia. (16932456)
2006
27
Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growth. (17535741)
2006
28
Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. (12520160)
2003
29
Ethnicity and unprovoked hypokalemia in the ARIC Study. (12118918)
2002
30
Disorders of potassium homeostasis. Hypokalemia and hyperkalemia. (12053834)
2002
31
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
32
Torsade de pointes with a normal QT interval associated with hypokalemia: a case report. (11502056)
2001
33
Evaluation of different nebulized bronchodilators on clinical efficacy and hypokalemia in asthmatic children. (11729705)
2001
34
The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis. (11045278)
2000
35
Saline-resistant metabolic alkalosis, severe hypokalemia and hypertension in a 74-year-old woman. (10661485)
2000
36
Adult celiac disease presented with celiac crisis: severe diarrhea, hypokalemia, and acidosis. (10777199)
2000
37
Hypokalemia-induced ultrastructural, histochemical and connexin-43 alterations resulting in atrial and ventricular fibrillations. (10707826)
1999
38
The effect of varying molar ratios of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. (9824785)
1998
39
Hypokalemia. (9700180)
1998
40
The effects of hypokalemia on the heart. (9231617)
1997
41
The influence of chronic hypokalemia on myocardial adrenergic receptor densities: enhanced sensitivity to epinephrine-induced arrhythmias. (9085948)
1997
42
Hypokalemia in a patient with pheochromocytoma. (15251511)
1996
43
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
44
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
45
ECG of the month. On a lower level. Hypokalemia. (1377739)
1992
46
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
47
Zollinger-Ellison syndrome: intermittent diarrhea, relentless hypokalemia, and hypergastrinemia. (7328691)
1981
48
Hypertension, hypokalemia and hypoaldosteronism with suppressed renin: a clinical study of a patient with Liddle's syndrome. (6273144)
1981
49
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
50
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. (4344758)
1972

Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

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Compounds for genes affiliated with Hypokalemia

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Compounds related to Hypokalemia according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1bendroflumethiazide43 1210.8SLC12A3, REN
2desmopressin43 59 28 1212.7REN, AQP2
3diazoxide43 59 28 1212.7SLC12A3, KCNJ1
4lithium43 49 24 1212.7AQP2, REN
5haloperidol43 49 28 2 1213.6REN, AQP2
6hydrocortisone43 2 59 1212.6AQP2, REN
7biotin43 24 1211.5AQP2, KCNJ1
8bumetanide43 59 28 49 1213.5SLC12A1, SLC12A3
9potassium chloride43 1210.4SLC12A1, REN
10prostaglandin439.4REN, AQP2
11urea43 24 1211.2AQP2, SLC12A1
12thiazide439.0REN, SLC12A1, SLC12A3
13arginine438.9REN, AQP2, KCNJ1
14forskolin43 49 1210.9AQP2, REN, SLC12A1
15pge2438.8SLC12A1, REN, AQP2
16chlorine43 249.8SLC12A3, SLC12A1, CLCNKB, BSND
17hydrochlorothiazide43 28 49 24 1212.7KCNJ1, AQP2, REN, SLC12A3
18nitric oxide43 24 1210.6SLC12A1, REN, AQP2
19threonine438.6AQP2, SLC12A1, SLC12A3
20alanine438.6SLC12A3, AQP2, KCNJ1
21magnesium43 24 1210.4KCNJ1, CLCNKB, AQP2, SLC12A1
22furosemide43 59 28 49 24 1213.1BSND, AQP2, REN, SLC12A1, SLC12A3
23calcium43 49 24 1210.7BSND, CLCNKB, AQP2, REN, SLC12A1, SLC12A3
24nacl437.1SLC12A3, BSND, KCNJ1, CLCNKB, AQP2, REN
25chloride437.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1
26potassium43 24 129.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1
27sodium43 248.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1

GO Terms for genes affiliated with Hypokalemia

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Cellular components related to Hypokalemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.6AQP2, BSND
2membraneGO:00160208.4SLC12A3, SLC12A1, AQP2
3plasma membraneGO:00058866.6SLC12A3, BSND, KCNJ1, CLCNKB, AQP2, REN

Biological processes related to Hypokalemia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chloride transportGO:00068219.3SLC12A3, SLC12A1
2sodium ion transportGO:00068149.3SLC12A3, SLC12A1
3kidney developmentGO:00018229.2REN, KCNJ1
4ion transportGO:00068119.2SLC12A3, SLC12A1
5excretionGO:00075889.1KCNJ1, CLCNKB, AQP2
6response to lipopolysaccharideGO:00324969.1REN, AQP2
7ion transmembrane transportGO:00342209.0SLC12A1, CLCNKB, BSND
8potassium ion transportGO:00068139.0KCNJ1, SLC12A1
9chloride transmembrane transportGO:019024769.0SLC12A3, SLC12A1, BSND
10transportGO:00068108.9CLCNKB, SLC12A1, SLC12A3
11transmembrane transportGO:00550858.1SLC12A3, SLC12A1, AQP2, CLCNKB, BSND

Products for genes affiliated with Hypokalemia

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Sources for Hypokalemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet