MCID: HYP005
MIFTS: 47

Hypokalemia malady

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Summaries for Hypokalemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards: Hypokalemia is related to hypertension and hyperaldosteronism. An important gene associated with Hypokalemia is BSND (Bartter syndrome, infantile, with sensorineural deafness (Barttin)), and among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The compounds bendroflumethiazide and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Hypokalemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt
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Aliases & Descriptions:

hypokalemia 8 10 45


External Ids:

Disease Ontology8 DOID:4500
NCIt40 C34939

Related Diseases for Hypokalemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.0SLC12A3, REN
2hyperaldosteronism30.5KCNJ1, CLCNKB, REN, SLC12A3
3gitelman syndrome30.2BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
4nephrocalcinosis30.1SLC12A1, CLCNKB, KCNJ1
5metabolic acidosis29.9SLC12A1, REN, AQP2
6essential hypertension29.9SLC12A3, SLC12A1, REN, AQP2
7congestive heart failure29.8REN, AQP2
8bartter disease29.7BSND, KCNJ1, CLCNKB, REN, SLC12A1, SLC12A3
9diarrhea10.5
10cushing's syndrome10.3
11adenoma10.3
12hypophosphatemia10.3
13leukemia10.3
14thyrotoxic periodic paralysis10.3
15brugada syndrome10.2
16peritonitis10.2
17quadriplegia10.2
18hyperglycemia10.2
19pheochromocytoma10.2
20wdha syndrome10.2
21diabetic ketoacidosis10.1
22vipoma10.1
23celiac disease10.1
24hypoglycemia10.1
25apparent mineralocorticoid excess syndrome10.1
26conn's syndrome10.1
27adrenal adenoma10.1
28islet cell tumor10.1
29kidney disease10.1
30long qt syndrome10.1
31respiratory failure10.1
32hypertensive hypokalemia familial10.1
33hypoaldosteronism10.1
34head injury10.1
35hepatorenal syndrome10.1REN
36diabetes insipidus10.1AQP2
37sensorineural hearing loss10.0BSND, CLCNKB
38pseudohypoaldosteronism type ii10.0REN, SLC12A3
39stroke, ischemic10.0SLC12A3, REN
40primary hyperoxaluria10.0SLC12A3, REN
41nephrolithiasis10.0
42hypercalcemia10.0
43liddle syndrome10.0
44acute myeloid leukemia10.0
45renal tubular acidosis10.0
46hypokalemic periodic paralysis10.0
47diabetes mellitus10.0
48eating disorder10.0
49ganglioneuroblastoma10.0
50glomerulonephritis10.0

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Symptoms for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hypokalemia

Search NIH Clinical Center for Hypokalemia

Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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33MalaCards
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MalaCards organs/tissues related to Hypokalemia:

33
Heart, Kidney, Liver, Brain, Myeloid, Lung, Pancreas, B cells, Prostate, Pituitary, Breast, Thyroid, Colon, Skeletal muscle, Testes, Eye, Spinal cord, Cortex

Animal Models for Hypokalemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypokalemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.7BSND, KCNJ1, REN, SLC12A1, SLC12A3
2MP:00053977.6BSND, KCNJ1, AQP2, REN, SLC12A1
3MP:00107687.6SLC12A1, REN, AQP2, KCNJ1, BSND
4MP:00053867.5SLC12A1, REN, AQP2, KCNJ1, BSND
5MP:00053787.3BSND, KCNJ1, AQP2, REN, SLC12A1
6MP:00053677.3SLC12A3, SLC12A1, REN, AQP2, KCNJ1, BSND
7MP:00053767.3BSND, KCNJ1, AQP2, REN, SLC12A1, SLC12A3

Publications for Hypokalemia

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52PubMed
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Articles related to Hypokalemia:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Etiology and symptoms of severe hypokalemia in emergency department patients. (23839104)
2014
2
Hypokalemia and hyperkalemia in infants and children: pathophysiology and treatment. (24139581)
2013
3
Thyrotoxic periodic paralysis: correct hypokalemia with caution. (23849367)
2013
4
Severe Hypokalemia in a Patient With Subarachnoid Hemorrhage. (23972266)
2013
5
Furosemide-induced severe hypokalemia with rhabdomyolysis without cardiac arrest. (23834955)
2013
6
It is never too late for a genetic disease: a case of a 79-year-old man with persistent hypokalemia. (23475471)
2013
7
Hypokalemia-induced pseudoischemic electrocardiographic changes and quadriplegia. (24176583)
2013
8
Central pontine and extrapontine myelinolysis secondary to fast correction of severe hyponatremia and hypokalemia in an alcoholic patient. (23180443)
2012
9
Polycystic kidney disease presenting with hypertension and hypokalemia. (21962616)
2012
10
Early recognition of reverse pseudohyperkalemia in heparin plasma samples during leukemic hyperleukocytosis can prevent iatrogenic hypokalemia. (22877885)
2012
11
Hypokalemia following polyethylene glycol-based bowel preparation for colonoscopy in older hospitalized patients with significant comorbidities. (20124467)
2010
12
A practical approach to genetic hypokalemia. (21468196)
2010
13
A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. (20338465)
2010
14
Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer. (19760217)
2010
15
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
16
Quiz Page September 2009. Long-standing high-renin hypertension and hypokalemia: renin-secreting tumor of the juxtaglomerular apparatus. (19700057)
2009
17
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
18
Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia. (18808610)
2008
19
Hypokalemia: a quick reference. (18402873)
2008
20
Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula. (17891350)
2007
21
Hypokalemia: a practical approach to diagnosis and its genetic basis. (17584063)
2007
22
Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. (16871112)
2006
23
A serum potassium level above 10 mmol/l in a patient predisposed to hypokalemia. (16932456)
2006
24
Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growth. (17535741)
2006
25
Atrial fibrillation and recurrent ventricular fibrillation during hypokalemia in Brugada syndrome. (16403168)
2005
26
Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. (12520160)
2003
27
Ethnicity and unprovoked hypokalemia in the ARIC Study. (12118918)
2002
28
Disorders of potassium homeostasis. Hypokalemia and hyperkalemia. (12053834)
2002
29
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
30
Torsade de pointes with a normal QT interval associated with hypokalemia: a case report. (11502056)
2001
31
Evaluation of different nebulized bronchodilators on clinical efficacy and hypokalemia in asthmatic children. (11729705)
2001
32
The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis. (11045278)
2000
33
Saline-resistant metabolic alkalosis, severe hypokalemia and hypertension in a 74-year-old woman. (10661485)
2000
34
Adult celiac disease presented with celiac crisis: severe diarrhea, hypokalemia, and acidosis. (10777199)
2000
35
Hypokalemia-induced ultrastructural, histochemical and connexin-43 alterations resulting in atrial and ventricular fibrillations. (10707826)
1999
36
Persistent hypokalemia after successful adrenalectomy in a patient with Cushing's syndrome due to ectopic ACTH secretion: possible role of 11beta-hydroxysteroid dehydrogenase inhibition. (10710274)
1999
37
The effect of varying molar ratios of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. (9824785)
1998
38
Hypokalemia. (9700180)
1998
39
The effects of hypokalemia on the heart. (9231617)
1997
40
The influence of chronic hypokalemia on myocardial adrenergic receptor densities: enhanced sensitivity to epinephrine-induced arrhythmias. (9085948)
1997
41
Hypokalemia in a patient with pheochromocytoma. (15251511)
1996
42
Aldosterone precursors and hypertension with hypokalemia and adrenal module non caused by primary hyperaldosteronism]. (8949378)
1996
43
Hypokalemia in opiate overdose. (7950162)
1994
44
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
45
ECG of the month. On a lower level. Hypokalemia. (1377739)
1992
46
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
47
Zollinger-Ellison syndrome: intermittent diarrhea, relentless hypokalemia, and hypergastrinemia. (7328691)
1981
48
Hypertension, hypokalemia and hypoaldosteronism with suppressed renin: a clinical study of a patient with Liddle's syndrome. (6273144)
1981
49
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
50
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. (4344758)
1972

Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

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50PathCards, 55Reactome, 51PharmGKB
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Compounds for genes affiliated with Hypokalemia

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1bendroflumethiazide45 1110.8SLC12A3, REN
2desmopressin45 61 29 1112.7REN, AQP2
3diazoxide45 61 29 1112.7SLC12A3, KCNJ1
4lithium45 51 24 1112.7AQP2, REN
5haloperidol45 51 29 3 1113.6REN, AQP2
6hydrocortisone45 3 61 1112.6AQP2, REN
7biotin45 24 1111.5AQP2, KCNJ1
8bumetanide45 61 29 51 1113.5SLC12A1, SLC12A3
9potassium chloride45 1110.4SLC12A1, REN
10prostaglandin459.4REN, AQP2
11urea45 24 1111.2AQP2, SLC12A1
12thiazide459.0REN, SLC12A1, SLC12A3
13arginine458.9REN, AQP2, KCNJ1
14forskolin45 51 1110.9AQP2, REN, SLC12A1
15pge2458.8SLC12A1, REN, AQP2
16chlorine45 249.8SLC12A3, SLC12A1, CLCNKB, BSND
17hydrochlorothiazide45 29 51 24 1112.7KCNJ1, AQP2, REN, SLC12A3
18nitric oxide45 24 1110.6SLC12A1, REN, AQP2
19threonine458.6AQP2, SLC12A1, SLC12A3
20alanine458.6SLC12A3, AQP2, KCNJ1
21magnesium45 24 1110.4KCNJ1, CLCNKB, AQP2, SLC12A1
22furosemide45 61 29 51 24 1113.1BSND, AQP2, REN, SLC12A1, SLC12A3
23calcium45 51 24 1110.7BSND, CLCNKB, AQP2, REN, SLC12A1, SLC12A3
24nacl457.1SLC12A3, BSND, KCNJ1, CLCNKB, AQP2, REN
25chloride457.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1
26potassium45 24 119.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1
27sodium45 248.1BSND, KCNJ1, CLCNKB, AQP2, REN, SLC12A1

GO Terms for genes affiliated with Hypokalemia

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16Gene Ontology
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Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.6AQP2, BSND
2membraneGO:0160208.4SLC12A3, SLC12A1, AQP2
3plasma membraneGO:0058866.6SLC12A3, BSND, KCNJ1, CLCNKB, AQP2, REN

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chloride transportGO:0068219.3SLC12A3, SLC12A1
2sodium ion transportGO:0068149.3SLC12A3, SLC12A1
3kidney developmentGO:0018229.2REN, KCNJ1
4ion transportGO:0068119.2SLC12A3, SLC12A1
5excretionGO:0075889.1KCNJ1, CLCNKB, AQP2
6response to lipopolysaccharideGO:0324969.1REN, AQP2
7ion transmembrane transportGO:0342209.0SLC12A1, CLCNKB, BSND
8potassium ion transportGO:0068139.0KCNJ1, SLC12A1
9chloride transmembrane transportGO:19024769.0SLC12A3, SLC12A1, BSND
10transportGO:0068108.9CLCNKB, SLC12A1, SLC12A3
11transmembrane transportGO:0550858.1SLC12A3, SLC12A1, AQP2, CLCNKB, BSND

Products for genes affiliated with Hypokalemia

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Sources for Hypokalemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet