MCID: HYP005
MIFTS: 50

Hypokalemia malady

Summaries for Hypokalemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards: Hypokalemia is related to hypertension and hyperaldosteronism. An important gene associated with Hypokalemia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are Cation-coupled Chloride cotransporters and Mineralocorticoid biosynthesis. The compounds norepinephrine and doca have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hypokalemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 39NCIt, 60UMLS
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Aliases & Descriptions:

hypokalemia 8 10 44


External Ids:

Disease Ontology8 DOID:4500
NCIt39 C34939

Related Diseases for Hypokalemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9HSD11B2, CYP17A1, REN, SLC12A3, ADRB2
2hyperaldosteronism30.5HSD11B2, REN, SLC12A3, KCNJ1, CYP17A1, CLCNKB
3gitelman syndrome30.4KCNJ1, SLC12A1, SLC12A3, CLCNKB, CASR, BSND
4cushing's syndrome30.4HSD11B2, CYP17A1, REN
5adenoma30.3KCNH2, HSD11B2, CASR, SLC9A3, CYP17A1, REN
6leukemia30.3KCNH2
7peritonitis30.2MB
8pheochromocytoma30.1ADRB2, VIP
9apparent mineralocorticoid excess syndrome30.1HSD11B2
10adrenal adenoma30.1HSD11B2, CYP17A1, REN
11nephrocalcinosis30.1KCNJ1, CASR, CLCNKB, SLC12A1
12conn's syndrome30.1REN, CYP17A1
13respiratory failure30.1PIK3C2A
14metabolic acidosis30.1PIK3C2A, MB, AQP2, SLC9A3, SLC12A1, REN
15pancreatitis29.9CASR
16nephrolithiasis29.9CASR, CLCNKB
17hypokalemic periodic paralysis29.9CACNA1S, SCN4A
18diabetes mellitus29.9SLC9A3, PIK3C2A, CASR, REN
19essential hypertension29.9AQP2, ADRB2, SLC12A3, SLC12A1, REN, HSD11B2
20myopathy29.9PIK3C2A, MB, CACNA1S, KCNH2, SCN4A
21bartter disease29.9SLC12A3, KCNJ1, CASR, SLC12A1, BSND, REN
22hyperparathyroidism29.7CASR
23congestive heart failure29.7REN
24hyperuricemia29.7PIK3C2A
25atrioventricular block29.7KCNH2, PIK3C2A
26adrenocortical carcinoma29.7VIP, HSD11B2, CYP17A1
27cholera29.7VIP, ADRB2, CYP17A1
28neuropathy29.7PIK3C2A, MB, KCNH2
29chronic kidney failure29.7AQP2, CASR, HSD11B2, BSND, REN
30adenocarcinoma29.7ADRB2, CASR, HSD11B2, VIP
31ischemia29.7VIP, ADRB2, ATP1A2, MB, PIK3C2A
32cystic fibrosis29.7ADRB2, SLC9A3, ATP6AP1, VIP, KCNJ1, AQP2
33status asthmaticus29.7PIK3C2A, ADRB2
34diarrhea10.5
35syndromic diarrhea10.3
36hypophosphatemia10.2
37brugada syndrome10.2
38acute leukemia10.2
39diabetic ketoacidosis10.1
40quadriplegia10.1
41hyperglycemia10.1
42long qt syndrome10.1
43vipoma10.1
44celiac disease10.1
45hypoglycemia10.1
46islet cell tumor10.1
47kidney disease10.1
48hypertensive hypokalemia familial10.1
49diabetes insipidus10.0AQP2
50leptospirosis10.0PIK3C2A

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Clinical Features for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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32MalaCards
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MalaCards organs/tissues related to Hypokalemia:

32
Heart, Kidney, Liver, Myeloid, Lung, Pancreas, Brain, Prostate, Colon, Pituitary, B cells, Testes, Breast, Thyroid, Skeletal muscle, Eye, Spinal cord, Cortex

Animal Models for Hypokalemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypokalemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3HSD11B2, KCNJ1, CASR, BSND, PIK3C2A, REN
2MP:00053979.3CASR, MB, BSND, PIK3C2A, REN, SLC12A1
3MP:00053699.2HSD11B2, KCNH2, CACNA1S, CASR, MB, SCN4A
4MP:00053859.0MB, KCNJ1, KCNH2, HSD11B2, VIP, BSND
5MP:00053868.9CASR, CACNA1S, KCNJ1, HSD11B2, VIP, SCN4A
6MP:00053788.6MB, CASR, CACNA1S, KCNJ1, KCNH2, SCN4A
7MP:00107688.5MB, CASR, CACNA1S, KCNJ1, KCNH2, HSD11B2
8MP:00053768.4AQP2, VIP, HSD11B2, KCNH2, KCNJ1, CACNA1S

Publications for Hypokalemia

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50PubMed
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Articles related to Hypokalemia:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Life-threatening hypokalemia following rapid correction of respiratory acidosis. (23669409)
2013
2
Rhabdomyolysis presenting with severe hypokalemia in hypertensive patients: a case series. (23594380)
2013
3
Hypokalemia, its contributing factors and renal outcomes in patients with chronic kidney disease. (23843989)
2013
4
Corrected QT Interval Prolongation during Severe Hypoglycemia without Hypokalemia in Patients with Type 2 Diabetes. (23807922)
2013
5
Early recognition of reverse pseudohyperkalemia in heparin plasma samples during leukemic hyperleukocytosis can prevent iatrogenic hypokalemia. (22877885)
2012
6
Pathophysiology of vomiting-induced hypokalemia and diagnostic approach. (22169581)
2012
7
Fatality after cardiac arrest in thyrotoxic periodic paralysis due to profound hypokalemia resulting from intravenous glucose administration and inadequate potassium replacement. (22827749)
2012
8
Severe hypokalemia due to an inappropriate formula milk. (21138850)
2012
9
The meaning of hypokalemia in heart failure. (21775000)
2012
10
Prevalence of hypokalemia in ED patients with diabetic ketoacidosis. (21316179)
2012
11
Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias. (22467308)
2012
12
Hypokalemia induced rhabdomyolysis. (21655176)
2011
13
Effects of hypokalemia and left ventricular hypertrophy on QT interval in patients with primary aldosteronism. (21907430)
2011
14
An association between transient hypokalemia and severe acute oxaliplatin-related toxicity predominantly in women. (20092386)
2010
15
Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. (19897712)
2010
16
High prevalence of hypokalemia after acute acetaminophen overdose: impact of psychiatric illness. (20144962)
2010
17
Hypokalemia, diabetes mellitus, and hypercortisolemia are the major contributing factors to cardiac dysfunction in adrenal Cushing's syndrome. (19789419)
2009
18
Hypokalemia: a quick reference. (18402873)
2008
19
Oral potassium chloride and oral rehydration solution supplement to prevent hypokalemia in sodium phosphate regimen for bowel preparation prior to gynecological laparoscopic surgery. (18672621)
2008
20
Diagnosis of hypokalemia: a problem-solving approach to clinical cases. (19377223)
2008
21
Centropontine myelinolysis after correction of hyponatremia: role of associated hypokalemia. (17598369)
2007
22
Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate. (17589195)
2007
23
Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. (16871112)
2006
24
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
25
Diuretics, hypokalemia, and cardiac arrhythmia: a 20-year controversy. (16470076)
2006
26
Profound hypokalemia in diabetic ketoacidosis: a therapeutic challenge. (16191494)
2005
27
Gitelman's syndrome--a differential diagnosis in hypokalemia]. (15114386)
2004
28
Role of potassium in hypokalemia-induced hyponatremia: lessons learned from the Edelman equation. (15235925)
2004
29
Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. (12520160)
2003
30
Prevalence and pathogenesis of hypokalemia in patients on chronic peritoneal dialysis: one center's experience and review of the literature. (15160552)
2003
31
Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases. (12381548)
2002
32
Sixty-eight-year-old patient with hypokalemia. (11246116)
2001
33
Hypokalemia associated with herbal tea ingestion. (11174037)
2001
34
Management of severe hypokalemia in hospitalized patients: a study of quality of care based on computerized databases. (11322843)
2001
35
Saline-resistant metabolic alkalosis, severe hypokalemia and hypertension in a 74-year-old woman. (10661485)
2000
36
Recurrent calcium oxalate urolithiasis in a man with familial periodic paralysis and hypokalemia. (10332462)
1999
37
Hypokalemia and salbutamol therapy in asthma. (10023788)
1999
38
Chronic microscopic enterocolitis with severe hypokalemia responding to subtotal colectomy. (10509959)
1999
39
Hypokalemia syndrome in dairy cows: 10 cases (1992-1996) (9018360)
1997
40
Brain concussion produces transient hypokalemia in children. (9021578)
1997
41
Effects of chronic hypokalemia on renal expression of the "gastric" H(+)-K(+)-ATPase alpha-subunit gene. (8967334)
1996
42
Hypokalemia in a pediatric intensive care unit. (8772944)
1996
43
Cortisol metabolism in hypertensive patients who do and do not develop hypokalemia from diuretics. (7662229)
1995
44
Acute onset of hypokalemia and muscular weakness in four hyperthyroid cats. (7928551)
1994
45
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1992. A 52-year-old man with hypertension, hypokalemia, and an adrenal mass. (1584263)
1992
46
Hypokalemia before induction of anesthesia and prevention by beta 2 adrenoceptor antagonism. (1845926)
1991
47
Insulin increases sodium reabsorption in diluting segment in humans: evidence for indirect mediation through hypokalemia. (1942773)
1991
48
Zollinger-Ellison syndrome: intermittent diarrhea, relentless hypokalemia, and hypergastrinemia. (7328691)
1981
49
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
50
PANCREATIC ADENOMA WITH INTRACTABLE DIARRHEA, HYPOKALEMIA, AND HYPERCALCEMIA. (14198901)
1964

Genetic Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Hypokalemia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5MB, VIP
2doca4410.5REN, CYP17A1, HSD11B2
3metoprolol44 28 49 11 2414.4KCNH2, REN, ADRB2
4forskolin44 49 1112.4REN, CYP17A1, HSD11B2, ADRB2
5thiazide4410.4CASR, REN, SLC12A1, SLC12A3
6bumetanide44 59 28 1113.4VIP, SLC12A1, SLC12A3
7potassium chloride44 1111.4VIP, REN, SLC12A1
8succinylcholine44 28 1112.4SCN4A, MB, PIK3C2A
9atenolol44 28 49 11 2414.4ADRB2, KCNH2, REN
10hydrochlorothiazide44 49 28 11 2414.3AQP2, HSD11B2, SLC12A3, REN, CASR
11dihydropyridine4410.3REN, CACNA1S, SCN4A
12furosemide44 49 59 28 11 2415.3SLC12A3, HSD11B2, BSND, REN, SLC12A1, AQP2
13propranolol44 28 49 11 2414.3ADRB2, KCNH2, VIP, REN
14diltiazem44 28 1112.2KCNH2, CACNA1S, REN
15corticosterone44 59 2412.2VIP, CYP17A1, HSD11B2, REN
16halothane44 28 1112.2PIK3C2A, REN, KCNH2, MB, ADRB2
17valine4410.1VIP, KCNH2, MB, SCN4A, CYP17A1
18isoproterenol44 1111.1KCNH2, VIP, ADRB2, REN, PIK3C2A
19chlorine44 2411.1SLC12A3, CLCNKB, BSND, SLC12A1
20catecholamine4410.1VIP, PIK3C2A, REN, ADRB2
21bicarbonate4410.1PIK3C2A, ATP6AP1, VIP, SLC9A3
22carvedilol44 49 28 1113.1REN, ADRB2, KCNH2
23haloperidol44 28 2 49 1114.1AQP2, REN, PIK3C2A, MB, VIP, KCNH2
24verapamil44 49 28 11 2414.1KCNH2, ADRB2, REN, CASR, VIP, CACNA1S
25sodium nitroprusside4410.0VIP, PIK3C2A, REN, MB
26acth4410.0REN, CYP17A1, HSD11B2, CASR, PIK3C2A, VIP
27epinephrine44 11 2412.0VIP, MB, PIK3C2A, ADRB2, AQP2, REN
28histidine4410.0MB, CYP17A1, SCN4A, CACNA1S, KCNH2
29pge2449.9AQP2, ADRB2, VIP, SLC12A1, REN, CASR
30prednisolone44 28 1111.9PIK3C2A, MB, VIP, HSD11B2
31hydrocortisone44 2 59 1112.9HSD11B2, REN, AQP2, SLC9A3
32dexamethasone44 49 28 1112.9HSD11B2, VIP, CYP17A1, REN, SLC9A3, AQP2
33hydrogen44 2410.8SLC9A3, KCNH2, CASR, MB, CYP17A1, ADRB2
34magnesium44 11 2411.8CASR, KCNJ1, SLC12A1, ATP1A2, PIK3C2A, AQP2
35cyclic amp44 2410.8KCNH2, ADRB2, SLC9A3, CYP17A1, CASR, VIP
36spironolactone49 44 59 28 1113.8REN, HSD11B2, KCNH2
37threonine449.8SLC12A1, CYP17A1, SLC12A3, KCNH2, ADRB2, AQP2
38nitric oxide44 11 2411.8ADRB2, AQP2, SLC9A3, SLC12A1, VIP, REN
39adenylate449.7VIP, CASR, KCNH2, MB, ADRB2, SLC9A3
40nacl449.7KCNJ1, CASR, BSND, REN, CLCNKB, SLC9A3
41glucose449.7SLC9A3, ADRB2, ATP1A2, HSD11B2, AQP2, PIK3C2A
42cysteine449.7HSD11B2, VIP, CASR, CYP17A1, MB, AQP2
43creatinine449.6MB, CASR, REN, ADRB2, KCNH2, HSD11B2
44alanine449.5ADRB2, SLC12A3, SLC9A3, PIK3C2A, VIP, KCNH2
45chloride449.4VIP, KCNJ1, CASR, SCN4A, BSND, REN
46serine449.4KCNJ1, CYP17A1, SLC9A3, SLC12A3, AQP2, MB
47arginine449.1MB, HSD11B2, KCNH2, KCNJ1, CACNA1S, VIP
48sodium44 2410.0KCNJ1, CACNA1S, CASR, SCN4A, BSND, PIK3C2A
49calcium44 49 11 2411.7ATP1A2, CYP17A1, ATP6AP1, CLCNKB, SLC9A3, SLC12A1
50potassium44 11 2410.6CLCNKB, REN, SLC9A3, SLC12A1, AQP2, ADRB2

GO Terms for genes affiliated with Hypokalemia

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16Gene Ontology
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Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7ADRB2, SLC12A3, CLCNKB, BSND, SCN4A, CASR
2apical plasma membraneGO:0163249.6SLC9A3, SLC12A3, ADRB2, AQP2
3plasma membraneGO:0058868.6AQP2, KCNH2, KCNJ1, CACNA1S, CASR, BSND

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:00681310.1SLC12A1, ATP1A2, KCNJ1
2sodium ion transportGO:00681410.1SLC12A3, SLC12A1, ATP1A2, SCN4A
3excretionGO:00758810.1AQP2, CLCNKB, KCNJ1
4ion transmembrane transportGO:03422010.0BSND, ATP1A2, CLCNKB, SLC12A1
5glucocorticoid biosynthetic processGO:0067049.9HSD11B2, CYP17A1
6transmembrane transportGO:0550859.8AQP2, BSND, ATP1A2, CLCNKB, SLC9A3, SLC12A1

Products for genes affiliated with Hypokalemia

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Sources for Hypokalemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet