MCID: HYP005
MIFTS: 50

Hypokalemia malady

Summaries for Hypokalemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards: Hypokalemia is related to gitelman syndrome and cushing's syndrome. An important gene associated with Hypokalemia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are Cation-coupled Chloride cotransporters and Mineralocorticoid biosynthesis. The compounds norepinephrine and doca have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hypokalemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 40NCIt, 61UMLS
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Aliases & Descriptions:

hypokalemia 8 10 45


External Ids:

Disease Ontology8 DOID:4500
NCIt40 C34939

Related Diseases for Hypokalemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1gitelman syndrome30.8KCNJ1, SLC12A1, SLC12A3, CLCNKB, CASR, BSND
2cushing's syndrome30.4HSD11B2, CYP17A1, REN
3adenoma30.4KCNH2, HSD11B2, CASR, SLC9A3, CYP17A1, REN
4pheochromocytoma30.2ADRB2, VIP
5apparent mineralocorticoid excess syndrome30.1HSD11B2
6adrenal adenoma30.1HSD11B2, CYP17A1, REN
7nephrocalcinosis30.1KCNJ1, CASR, CLCNKB, SLC12A1
8conn's syndrome30.1REN, CYP17A1
9nephrolithiasis30.0CASR, CLCNKB
10hypokalemic periodic paralysis30.0CACNA1S, SCN4A
11bartter disease30.0SLC12A3, KCNJ1, CASR, SLC12A1, BSND, REN
12metabolic acidosis30.0PIK3C2A, MB, AQP2, SLC9A3, SLC12A1, REN
13hyperuricemia29.7PIK3C2A
14atrioventricular block29.7KCNH2, PIK3C2A
15adrenocortical carcinoma29.7VIP, HSD11B2, CYP17A1
16cholera29.7VIP, ADRB2, CYP17A1
17adenocarcinoma29.7ADRB2, CASR, HSD11B2, VIP
18cystic fibrosis29.7ADRB2, SLC9A3, ATP6AP1, VIP, KCNJ1, AQP2
19status asthmaticus29.7PIK3C2A, ADRB2
20thyrotoxic periodic paralysis10.3
21n syndrome10.3
22hypophosphatemia10.2
23brugada syndrome10.2
24acute leukemia10.2
25asthma10.2
26wdha syndrome10.2
27diabetic ketoacidosis10.1
28quadriplegia10.1
29liddle syndrome10.1
30vipoma10.1
31celiac disease10.1
32hypoglycemia10.1
33hypertensive hypokalemia familial10.1
34hypoaldosteronism10.1
35head injury10.1
36acute myeloid leukemia10.0
37central pontine myelinolysis10.0
38hypercalcemia10.0
39adult syndrome10.0
40renal tubular acidosis10.0
41renal tubular acidosis, distal10.0
42extrapontine myelinolysis10.0
43thyrotoxic periodic paralysis 110.0
44diabetes insipidus10.0AQP2
45leptospirosis10.0PIK3C2A
46myasthenia gravis10.0ADRB2
47anuria10.0MB
48malignant hyperthermia susceptibility10.0CACNA1S
49hyperparathyroidism10.0CASR
50sjogren's syndrome10.0VIP

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Clinical Features for Hypokalemia

Drugs & Therapeutics for Hypokalemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypokalemia

Drug clinical trials:

Search ClinicalTrials for Hypokalemia

Search NIH Clinical Center for Hypokalemia

Search CenterWatch for Hypokalemia

Genetic Tests for Hypokalemia

Anatomical Context for Hypokalemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypokalemia:

33
Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Prostate, Myeloid, T cells, B lymphoblasts, B cells, Pancreatic islet, Adrenal cortex, Pituitary

Animal Models for Hypokalemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypokalemia

Sources:
51PubMed
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Articles related to Hypokalemia:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Severe Hypokalemia in a Patient With Subarachnoid Hemorrhage. (23972266)
2013
2
Furosemide-induced severe hypokalemia with rhabdomyolysis without cardiac arrest. (23834955)
2013
3
Hypokalemia Promotes Late Phase 3 Early Afterdepolarization and Recurrent Ventricular Fibrillation During Isoproterenol Infusion in Langendorff Perfused Rabbit Ventricles. (24378768)
2013
4
Post-operative severe hypokalemia mimicking myocardial ischemia. (24250008)
2013
5
Wilson's disease presenting with hypokalemia, hypoparathyroidism and renal failure. (23547415)
2012
6
The effect of patient-controlled intravenous analgesia on postoperative hypokalemia in patients undergoing laparoscopic cholecystectomy. (21863389)
2011
7
Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis. (22022014)
2011
8
Hypokalemia is associated with increased mortality rate in chronic hemodialysis patients. (21849775)
2011
9
TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia. (21653227)
2011
10
Severe hypokalemia in 2 young bicycle riders due to massive caffeine intake. (20215898)
2010
11
Mechanisms of hypokalemia-induced ventricular arrhythmogenicity. (20584206)
2010
12
Pregnancy predisposes to rhabdomyolysis due to hypokalemia. (21060186)
2010
13
Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. (19654201)
2009
14
Hypokalemia, metabolic alkalosis, and hypertension in a lung cancer patient. (18813287)
2009
15
High prevalence of hypokalemia in acute psychiatric inpatients. (19410105)
2009
16
Inherited renal tubular defects with hypokalemia. (19237818)
2009
17
Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. (19792989)
2009
18
Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary cortisol levels. (19388868)
2009
19
Life-threatening ventricular arrhythmia induced by hypokalemia during sodium bicarbonate infusion. (18364634)
2008
20
Acute hypokalemia may not be an effective way to sensitize the in situ canine heart for sparfloxacin-induced long QT syndrome. (16404129)
2006
21
Symptomatic hypokalemia associated with infliximab in a patient with Crohn's disease. (17012977)
2006
22
Hypokalemia from risperidone and quetiapine overdose. (15754671)
2005
23
Severe hypokalemia occurring during barbiturate coma therapy in a patient with severe acute head injury. (15954980)
2005
24
Severe hypokalemia and rhabdomyolysis associated with itraconazole therapy. (14628780)
2003
25
Hypokalemia with venlafaxine. (12469691)
2002
26
Another case of excessive caffeine and hypokalemia in pregnancy. (11704186)
2001
27
Propranolol rapidly reverses paralysis, hypokalemia, and hypophosphatemia in thyrotoxic periodic paralysis. (11228188)
2001
28
Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity. (11553508)
2001
29
The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis. (11045278)
2000
30
Persistent hypokalemia after successful adrenalectomy in a patient with Cushing's syndrome due to ectopic ACTH secretion: possible role of 11beta-hydroxysteroid dehydrogenase inhibition. (10710274)
1999
31
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. (10401023)
1999
32
The effect of varying molar ratios of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. (9824785)
1998
33
Quantitation of tremor in response to beta-adrenergic receptor stimulation in primates: relationship with hypokalemia. (10465154)
1998
34
Laxative-induced hypokalemia. (9774942)
1998
35
ECG changes during furosemide-induced hypokalemia in the rat. (9533377)
1998
36
The influence of chronic hypokalemia on myocardial adrenergic receptor densities: enhanced sensitivity to epinephrine-induced arrhythmias. (9085948)
1997
37
Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. (9408707)
1997
38
Effect of chronic hypokalemia on H(+)-K(+)-ATPase expression in rat colon. (9039045)
1997
39
Role of epinephrine-induced hypokalemia in the regulation of renin and aldosterone in humans. (8592096)
1996
40
QRS alteration-induced torsade de pointes in a patient with an artificial pacemaker and hypokalemia. (8741247)
1996
41
Hypokalemia in eating disorders. (8561221)
1996
42
Hypokalemia in opiate overdose. (7950162)
1994
43
Prevention of hypokalemia caused by diuretics. (8199766)
1994
44
Unilateral renal artery stenosis seen initially as severe and symptomatic hypokalemia. Pathophysiologic assessment and effects of surgical revascularization. (8442694)
1993
45
T wave inversion in a woman with giddiness and weakness. Hypokalemia. (8266213)
1993
46
Giant negative U waves in a patient with uncontrolled hypertension and severe hypokalemia. (1522400)
1992
47
Hypokalemia induced by inhaled bronchodilators. (3168573)
1988
48
'Essential' hypertension with hypokalemia. Caused by aldosterone-secreting adrenal adenoma. (6462970)
1984
49
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. (4344758)
1972
50
Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. (13571250)
1958

Genetic Variations for Hypokalemia

Expression for genes affiliated with Hypokalemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 50PharmGKB
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Compounds for genes affiliated with Hypokalemia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.5MB, VIP
2doca4510.5REN, CYP17A1, HSD11B2
3metoprolol45 29 50 11 2414.4KCNH2, REN, ADRB2
4forskolin45 50 1112.4REN, CYP17A1, HSD11B2, ADRB2
5thiazide4510.4CASR, REN, SLC12A1, SLC12A3
6bumetanide45 60 29 1113.4VIP, SLC12A1, SLC12A3
7potassium chloride45 1111.4VIP, REN, SLC12A1
8succinylcholine45 29 1112.4SCN4A, MB, PIK3C2A
9atenolol45 29 50 11 2414.4ADRB2, KCNH2, REN
10hydrochlorothiazide45 50 29 11 2414.3AQP2, HSD11B2, SLC12A3, REN, CASR
11dihydropyridine4510.3REN, CACNA1S, SCN4A
12furosemide45 50 60 29 11 2415.3SLC12A3, HSD11B2, BSND, REN, SLC12A1, AQP2
13propranolol45 29 50 11 2414.3ADRB2, KCNH2, VIP, REN
14diltiazem45 29 1112.2KCNH2, CACNA1S, REN
15corticosterone45 60 2412.2VIP, CYP17A1, HSD11B2, REN
16halothane45 29 1112.2PIK3C2A, REN, KCNH2, MB, ADRB2
17valine4510.1VIP, KCNH2, MB, SCN4A, CYP17A1
18isoproterenol45 1111.1KCNH2, VIP, ADRB2, REN, PIK3C2A
19chlorine45 2411.1SLC12A3, CLCNKB, BSND, SLC12A1
20catecholamine4510.1VIP, PIK3C2A, REN, ADRB2
21bicarbonate4510.1PIK3C2A, ATP6AP1, VIP, SLC9A3
22carvedilol45 50 29 1113.1REN, ADRB2, KCNH2
23haloperidol45 29 2 50 1114.1AQP2, REN, PIK3C2A, MB, VIP, KCNH2
24verapamil45 50 29 11 2414.1KCNH2, ADRB2, REN, CASR, VIP, CACNA1S
25sodium nitroprusside4510.0VIP, PIK3C2A, REN, MB
26acth4510.0REN, CYP17A1, HSD11B2, CASR, PIK3C2A, VIP
27epinephrine45 11 2412.0VIP, MB, PIK3C2A, ADRB2, AQP2, REN
28histidine4510.0MB, CYP17A1, SCN4A, CACNA1S, KCNH2
29pge2459.9AQP2, ADRB2, VIP, SLC12A1, REN, CASR
30prednisolone45 29 1111.9PIK3C2A, MB, VIP, HSD11B2
31hydrocortisone45 2 60 1112.9HSD11B2, REN, AQP2, SLC9A3
32dexamethasone45 50 29 1112.9HSD11B2, VIP, CYP17A1, REN, SLC9A3, AQP2
33hydrogen45 2410.8SLC9A3, KCNH2, CASR, MB, CYP17A1, ADRB2
34magnesium45 11 2411.8CASR, KCNJ1, SLC12A1, ATP1A2, PIK3C2A, AQP2
35cyclic amp45 2410.8KCNH2, ADRB2, SLC9A3, CYP17A1, CASR, VIP
36spironolactone50 45 60 29 1113.8REN, HSD11B2, KCNH2
37threonine459.8SLC12A1, CYP17A1, SLC12A3, KCNH2, ADRB2, AQP2
38nitric oxide45 11 2411.8ADRB2, AQP2, SLC9A3, SLC12A1, VIP, REN
39adenylate459.7VIP, CASR, KCNH2, MB, ADRB2, SLC9A3
40nacl459.7KCNJ1, CASR, BSND, REN, CLCNKB, SLC9A3
41glucose459.7SLC9A3, ADRB2, ATP1A2, HSD11B2, AQP2, PIK3C2A
42cysteine459.7HSD11B2, VIP, CASR, CYP17A1, MB, AQP2
43creatinine459.6MB, CASR, REN, ADRB2, KCNH2, HSD11B2
44alanine459.5ADRB2, SLC12A3, SLC9A3, PIK3C2A, VIP, KCNH2
45chloride459.4VIP, KCNJ1, CASR, SCN4A, BSND, REN
46serine459.4KCNJ1, CYP17A1, SLC9A3, SLC12A3, AQP2, MB
47arginine459.1MB, HSD11B2, KCNH2, KCNJ1, CACNA1S, VIP
48sodium45 2410.0KCNJ1, CACNA1S, CASR, SCN4A, BSND, PIK3C2A
49calcium45 50 11 2411.7ATP1A2, CYP17A1, ATP6AP1, CLCNKB, SLC9A3, SLC12A1
50potassium45 11 2410.6CLCNKB, REN, SLC9A3, SLC12A1, AQP2, ADRB2

GO Terms for genes affiliated with Hypokalemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7BSND, SCN4A, CASR, SLC12A3, ADRB2, CLCNKB
2apical plasma membraneGO:0163249.6SLC12A3, ADRB2, AQP2, SLC9A3
3plasma membraneGO:0058868.6AQP2, KCNH2, KCNJ1, CACNA1S, CASR, BSND

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:00681310.1KCNJ1, ATP1A2, SLC12A1
2sodium ion transportGO:00681410.1SCN4A, ATP1A2, SLC12A1, SLC12A3
3excretionGO:00758810.1KCNJ1, CLCNKB, AQP2
4ion transmembrane transportGO:03422010.0BSND, SLC12A1, CLCNKB, ATP1A2
5glucocorticoid biosynthetic processGO:0067049.9HSD11B2, CYP17A1
6transmembrane transportGO:0550859.8BSND, ATP1A2, CLCNKB, SLC9A3, SLC12A1, AQP2

Products for genes affiliated with Hypokalemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypokalemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet