MCID: HYP005
MIFTS: 50

Hypokalemia malady

Summaries for Hypokalemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards: Hypokalemia is related to hypertension and hyperaldosteronism. An important gene associated with Hypokalemia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are Cation-coupled Chloride cotransporters and Mineralocorticoid biosynthesis. The compounds norepinephrine and doca have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hypokalemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 39NCIt, 60UMLS
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Aliases & Descriptions:

hypokalemia 8 10 44


External Ids:

Disease Ontology8 DOID:4500
NCIt39 C34939

Related Diseases for Hypokalemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9HSD11B2, CYP17A1, REN, SLC12A3, ADRB2
2hyperaldosteronism30.5HSD11B2, REN, SLC12A3, KCNJ1, CYP17A1, CLCNKB
3gitelman syndrome30.4KCNJ1, SLC12A1, SLC12A3, CLCNKB, CASR, BSND
4cushing's syndrome30.4HSD11B2, CYP17A1, REN
5adenoma30.3KCNH2, HSD11B2, CASR, SLC9A3, CYP17A1, REN
6leukemia30.3KCNH2
7peritonitis30.2MB
8pheochromocytoma30.1ADRB2, VIP
9apparent mineralocorticoid excess syndrome30.1HSD11B2
10adrenal adenoma30.1HSD11B2, CYP17A1, REN
11nephrocalcinosis30.1KCNJ1, CASR, CLCNKB, SLC12A1
12conn's syndrome30.1REN, CYP17A1
13respiratory failure30.1PIK3C2A
14metabolic acidosis30.1PIK3C2A, MB, AQP2, SLC9A3, SLC12A1, REN
15pancreatitis29.9CASR
16nephrolithiasis29.9CASR, CLCNKB
17hypokalemic periodic paralysis29.9CACNA1S, SCN4A
18diabetes mellitus29.9SLC9A3, PIK3C2A, CASR, REN
19essential hypertension29.9AQP2, ADRB2, SLC12A3, SLC12A1, REN, HSD11B2
20myopathy29.9PIK3C2A, MB, CACNA1S, KCNH2, SCN4A
21bartter disease29.9SLC12A3, KCNJ1, CASR, SLC12A1, BSND, REN
22hyperparathyroidism29.7CASR
23congestive heart failure29.7REN
24hyperuricemia29.7PIK3C2A
25atrioventricular block29.7KCNH2, PIK3C2A
26adrenocortical carcinoma29.7VIP, HSD11B2, CYP17A1
27cholera29.7VIP, ADRB2, CYP17A1
28neuropathy29.7PIK3C2A, MB, KCNH2
29chronic kidney failure29.7AQP2, CASR, HSD11B2, BSND, REN
30adenocarcinoma29.7ADRB2, CASR, HSD11B2, VIP
31ischemia29.7VIP, ADRB2, ATP1A2, MB, PIK3C2A
32cystic fibrosis29.7ADRB2, SLC9A3, ATP6AP1, VIP, KCNJ1, AQP2
33status asthmaticus29.7PIK3C2A, ADRB2
34diarrhea10.5
35syndromic diarrhea10.3
36hypophosphatemia10.2
37brugada syndrome10.2
38acute leukemia10.2
39diabetic ketoacidosis10.1
40quadriplegia10.1
41hyperglycemia10.1
42long qt syndrome10.1
43vipoma10.1
44celiac disease10.1
45hypoglycemia10.1
46islet cell tumor10.1
47kidney disease10.1
48hypertensive hypokalemia familial10.1
49diabetes insipidus10.0AQP2
50leptospirosis10.0PIK3C2A

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Clinical Features for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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32MalaCards
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MalaCards organs/tissues related to Hypokalemia:

32
Heart, Kidney, Liver, Lung, Pancreas, Myeloid, Brain, Prostate, B cells, Breast, Testes, Thyroid, Eye, Colon, Skeletal muscle, Spinal cord, Cortex, Pituitary

Animal Models for Hypokalemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypokalemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3SLC9A3, HSD11B2, KCNJ1, CASR, PIK3C2A, REN
2MP:00053979.3CASR, BSND, PIK3C2A, REN, MB, SLC12A1
3MP:00053699.2REN, HSD11B2, KCNH2, SCN4A, ADRB2, CASR
4MP:00053859.0SLC9A3, ADRB2, REN, KCNJ1, ATP1A2, BSND
5MP:00053868.9ATP1A2, BSND, SCN4A, CASR, CACNA1S, KCNJ1
6MP:00053788.6MB, ADRB2, AQP2, KCNH2, KCNJ1, CACNA1S
7MP:00107688.5BSND, PIK3C2A, ATP6AP1, ATP1A2, CYP17A1, MB
8MP:00053768.4CASR, KCNH2, KCNJ1, CACNA1S, SLC12A1, MB

Publications for Hypokalemia

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50PubMed
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Articles related to Hypokalemia:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Etiology and symptoms of severe hypokalemia in emergency department patients. (23839104)
2014
2
Severe Hypokalemia Probably Associated With Sertraline Use. (24259656)
2013
3
Hypokalemia during the early phase of refeeding in patients with cancer. (24270952)
2013
4
Licorice-induced severe hypokalemia with recurrent torsade de pointes. (24303973)
2013
5
Expression of glutamine synthetase in the mouse kidney: localization in multiple epithelial cell types and differential regulation by hypokalemia. (23804452)
2013
6
Significance of Serum Potassium Level Monitoring during the Course of Post-Operative Rehabilitation in Patients with Hypokalemia. (24202399)
2013
7
Central pontine and extrapontine myelinolysis secondary to fast correction of severe hyponatremia and hypokalemia in an alcoholic patient. (23180443)
2012
8
Eplerenone improved hypokalemia in a patient with Gitelman's syndrome. (22214629)
2012
9
Recurrent ventricular fibrillation related to hypokalemia in early repolarization syndrome. (22734973)
2012
10
Gitelman's syndrome with persistent hypokalemia - don't forget licorice, alcohol, lemon juice, iced tea and salt depletion: a case report. (21756318)
2011
11
Hypocalcemia and hypokalemia due to hyperventilation syndrome in spinal anesthesia -A case report-. (22220232)
2011
12
Mechanism underlying hypokalemia induced by trimethyltin chloride: Inhibition of H+/K+-ATPase in renal intercalated cells. (20211677)
2010
13
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
14
Hypokalemia. (19543049)
2009
15
Hypokalemia. (18326944)
2008
16
Hypokalemia during sickle cell crises apparently due to intermittent mineralocorticoid excess. (18215710)
2008
17
Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. (17473492)
2007
18
Effects of dofetilide and EGIS-7229, an antiarrhythmic agent possessing class III, IV, and IB activities, on myocardial refractoriness in hyperkalemia, hypokalemia, and during beta-adrenergic activation in the rabbit papillary muscle in vitro. (16603803)
2006
19
Hypokalemia causing rhabdomyolysis resulting in life-threatening hyperkalemia. (16252109)
2006
20
Loss of consciousness and hypokalemia in an elderly man with a mutation of the thiazide-sensitive Na-Cl cotransporter gene. (16966826)
2006
21
Hypokalemia in Chinese peritoneal dialysis patients: prevalence and prognostic implication. (15983966)
2005
22
Effect of insulin-induced hypokalemia on lumbar sympathetic nerve activity in anesthetized rats. (15311104)
2004
23
Hypokalemia and hypomagnesemia of hereditary renal tubular origin. Bartter and Gitelman syndromes. (15055023)
2003
24
A case of hypokalemia and rhabdomyolysis in a patient with short bowel syndrome. (12903898)
2003
25
Hypokalemia following trauma. (12166770)
2002
26
Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia. (11227957)
2001
27
Gitelman's syndrome (familial hypokalemia-hypomagnesemia). (11281344)
2001
28
Adult celiac disease presented with celiac crisis: severe diarrhea, hypokalemia, and acidosis. (10777199)
2000
29
Effects of hypokalemia on cardiac growth. (11041288)
2000
30
Torsade de pointes associated with hypokalemia after anthracycline treatment in a patient with acute lymphocytic leukemia. (10745628)
2000
31
Hypokalemia-induced ultrastructural, histochemical and connexin-43 alterations resulting in atrial and ventricular fibrillations. (10707826)
1999
32
Correction: Treatment of Hypokalemia. (10029653)
1999
33
In rat tIMCD, NH4+ uptake by Na+-K+-ATPase is critical to net acid secretion during chronic hypokalemia. (10600933)
1999
34
Abnormal physiological conditions in acute schizophrenic patients on emergency admission: dehydration, hypokalemia, leukocytosis and elevated serum muscle enzymes. (9810481)
1998
35
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. (9844143)
1998
36
A patient with hypertension and persistent hypokalemia. (9791394)
1998
37
Hypokalemia--consequences, causes, and correction. (9219169)
1997
38
Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent. (9048354)
1997
39
Hypokalemia and hyperkalemia. (9167648)
1997
40
Thyrotoxic periodic paralysis associated with hypokalemia and hypophosphatemia. (8768924)
1996
41
Hypokalemia after normal doses of neubulized albuterol (salbutamol). (7893301)
1995
42
Hypokalemia in outpatients with eating disorders. (7802122)
1995
43
Acute hypokalemia is well tolerated in infants during liver transplantation. (8108914)
1994
44
Clinical relevance and management of the major electrolyte abnormalities in congestive heart failure: hyponatremia, hypokalemia, and hypomagnesemia. (8074021)
1994
45
Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome. (8080005)
1994
46
Hypokalemia: are elderly females more vulnerable? (8107162)
1993
47
Number impairments following hypokalemia: a case study. (1743040)
1991
48
Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis. (3287913)
1988
49
Role of exogenous factors in alterations of red cell Na+-Li+ exchange and Na+-K+ cotransport in essential hypertension, primary hyperaldosteronism, and hypokalemia. (3012766)
1986
50
Effect of indomethacin in two siblings with a renin-dependent hypertension, hyperaldosteronism and hypokalemia. (7352042)
1980

Genetic Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Hypokalemia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5MB, VIP
2doca4410.5REN, CYP17A1, HSD11B2
3metoprolol44 28 49 11 2414.4KCNH2, REN, ADRB2
4forskolin44 49 1112.4REN, CYP17A1, HSD11B2, ADRB2
5thiazide4410.4CASR, REN, SLC12A1, SLC12A3
6bumetanide44 59 28 1113.4VIP, SLC12A1, SLC12A3
7potassium chloride44 1111.4VIP, REN, SLC12A1
8succinylcholine44 28 1112.4SCN4A, MB, PIK3C2A
9atenolol44 28 49 11 2414.4ADRB2, KCNH2, REN
10hydrochlorothiazide44 49 28 11 2414.3AQP2, HSD11B2, SLC12A3, REN, CASR
11dihydropyridine4410.3REN, CACNA1S, SCN4A
12furosemide44 49 59 28 11 2415.3SLC12A3, HSD11B2, BSND, REN, SLC12A1, AQP2
13propranolol44 28 49 11 2414.3ADRB2, KCNH2, VIP, REN
14diltiazem44 28 1112.2KCNH2, CACNA1S, REN
15corticosterone44 59 2412.2VIP, CYP17A1, HSD11B2, REN
16halothane44 28 1112.2PIK3C2A, REN, KCNH2, MB, ADRB2
17valine4410.1VIP, KCNH2, MB, SCN4A, CYP17A1
18isoproterenol44 1111.1KCNH2, VIP, ADRB2, REN, PIK3C2A
19chlorine44 2411.1SLC12A3, CLCNKB, BSND, SLC12A1
20catecholamine4410.1VIP, PIK3C2A, REN, ADRB2
21bicarbonate4410.1PIK3C2A, ATP6AP1, VIP, SLC9A3
22carvedilol44 49 28 1113.1REN, ADRB2, KCNH2
23haloperidol44 28 2 49 1114.1AQP2, REN, PIK3C2A, MB, VIP, KCNH2
24verapamil44 49 28 11 2414.1KCNH2, ADRB2, REN, CASR, VIP, CACNA1S
25sodium nitroprusside4410.0VIP, PIK3C2A, REN, MB
26acth4410.0REN, CYP17A1, HSD11B2, CASR, PIK3C2A, VIP
27epinephrine44 11 2412.0VIP, MB, PIK3C2A, ADRB2, AQP2, REN
28histidine4410.0MB, CYP17A1, SCN4A, CACNA1S, KCNH2
29pge2449.9AQP2, ADRB2, VIP, SLC12A1, REN, CASR
30prednisolone44 28 1111.9PIK3C2A, MB, VIP, HSD11B2
31hydrocortisone44 2 59 1112.9HSD11B2, REN, AQP2, SLC9A3
32dexamethasone44 49 28 1112.9HSD11B2, VIP, CYP17A1, REN, SLC9A3, AQP2
33hydrogen44 2410.8SLC9A3, KCNH2, CASR, MB, CYP17A1, ADRB2
34magnesium44 11 2411.8CASR, KCNJ1, SLC12A1, ATP1A2, PIK3C2A, AQP2
35cyclic amp44 2410.8KCNH2, ADRB2, SLC9A3, CYP17A1, CASR, VIP
36spironolactone49 44 59 28 1113.8REN, HSD11B2, KCNH2
37threonine449.8SLC12A1, CYP17A1, SLC12A3, KCNH2, ADRB2, AQP2
38nitric oxide44 11 2411.8ADRB2, AQP2, SLC9A3, SLC12A1, VIP, REN
39adenylate449.7VIP, CASR, KCNH2, MB, ADRB2, SLC9A3
40nacl449.7KCNJ1, CASR, BSND, REN, CLCNKB, SLC9A3
41glucose449.7SLC9A3, ADRB2, ATP1A2, HSD11B2, AQP2, PIK3C2A
42cysteine449.7HSD11B2, VIP, CASR, CYP17A1, MB, AQP2
43creatinine449.6MB, CASR, REN, ADRB2, KCNH2, HSD11B2
44alanine449.5ADRB2, SLC12A3, SLC9A3, PIK3C2A, VIP, KCNH2
45chloride449.4VIP, KCNJ1, CASR, SCN4A, BSND, REN
46serine449.4KCNJ1, CYP17A1, SLC9A3, SLC12A3, AQP2, MB
47arginine449.1MB, HSD11B2, KCNH2, KCNJ1, CACNA1S, VIP
48sodium44 2410.0KCNJ1, CACNA1S, CASR, SCN4A, BSND, PIK3C2A
49calcium44 49 11 2411.7ATP1A2, CYP17A1, ATP6AP1, CLCNKB, SLC9A3, SLC12A1
50potassium44 11 2410.6CLCNKB, REN, SLC9A3, SLC12A1, AQP2, ADRB2

GO Terms for genes affiliated with Hypokalemia

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16Gene Ontology
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Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7BSND, SCN4A, CASR, SLC12A3, ADRB2, CLCNKB
2apical plasma membraneGO:0163249.6SLC12A3, ADRB2, AQP2, SLC9A3
3plasma membraneGO:0058868.6AQP2, KCNH2, KCNJ1, CACNA1S, CASR, BSND

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:00681310.1KCNJ1, ATP1A2, SLC12A1
2sodium ion transportGO:00681410.1SCN4A, ATP1A2, SLC12A1, SLC12A3
3excretionGO:00758810.1KCNJ1, CLCNKB, AQP2
4ion transmembrane transportGO:03422010.0BSND, SLC12A1, CLCNKB, ATP1A2
5glucocorticoid biosynthetic processGO:0067049.9HSD11B2, CYP17A1
6transmembrane transportGO:0550859.8BSND, ATP1A2, CLCNKB, SLC9A3, SLC12A1, AQP2

Products for genes affiliated with Hypokalemia

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  • Antibodies
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Sources for Hypokalemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet