MCID: HYP005
MIFTS: 50

Hypokalemia malady

Summaries for Hypokalemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypokalemia (American English) or hypokalaemia (British English), also hypopotassemia or hypopotassaemia... more...

MalaCards: Hypokalemia is related to hypertension and hyperaldosteronism. An important gene associated with Hypokalemia is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are Cation-coupled Chloride cotransporters and Mineralocorticoid biosynthesis. The compounds norepinephrine and doca have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hypokalemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 39NCIt, 60UMLS
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Aliases & Descriptions:

hypokalemia 8 10 44


External Ids:

Disease Ontology8 DOID:4500
NCIt39 C34939

Related Diseases for Hypokalemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9HSD11B2, CYP17A1, REN, SLC12A3, ADRB2
2hyperaldosteronism30.5HSD11B2, REN, SLC12A3, KCNJ1, CYP17A1, CLCNKB
3gitelman syndrome30.4KCNJ1, SLC12A1, SLC12A3, CLCNKB, CASR, BSND
4cushing's syndrome30.4HSD11B2, CYP17A1, REN
5adenoma30.3KCNH2, HSD11B2, CASR, SLC9A3, CYP17A1, REN
6leukemia30.3KCNH2
7peritonitis30.2MB
8pheochromocytoma30.1ADRB2, VIP
9apparent mineralocorticoid excess syndrome30.1HSD11B2
10adrenal adenoma30.1HSD11B2, CYP17A1, REN
11nephrocalcinosis30.1KCNJ1, CASR, CLCNKB, SLC12A1
12conn's syndrome30.1REN, CYP17A1
13respiratory failure30.1PIK3C2A
14metabolic acidosis30.1PIK3C2A, MB, AQP2, SLC9A3, SLC12A1, REN
15pancreatitis29.9CASR
16nephrolithiasis29.9CASR, CLCNKB
17hypokalemic periodic paralysis29.9CACNA1S, SCN4A
18diabetes mellitus29.9SLC9A3, PIK3C2A, CASR, REN
19essential hypertension29.9AQP2, ADRB2, SLC12A3, SLC12A1, REN, HSD11B2
20myopathy29.9PIK3C2A, MB, CACNA1S, KCNH2, SCN4A
21bartter disease29.9SLC12A3, KCNJ1, CASR, SLC12A1, BSND, REN
22hyperparathyroidism29.7CASR
23congestive heart failure29.7REN
24hyperuricemia29.7PIK3C2A
25atrioventricular block29.7KCNH2, PIK3C2A
26adrenocortical carcinoma29.7VIP, HSD11B2, CYP17A1
27cholera29.7VIP, ADRB2, CYP17A1
28neuropathy29.7PIK3C2A, MB, KCNH2
29chronic kidney failure29.7AQP2, CASR, HSD11B2, BSND, REN
30adenocarcinoma29.7ADRB2, CASR, HSD11B2, VIP
31ischemia29.7VIP, ADRB2, ATP1A2, MB, PIK3C2A
32cystic fibrosis29.7ADRB2, SLC9A3, ATP6AP1, VIP, KCNJ1, AQP2
33status asthmaticus29.7PIK3C2A, ADRB2
34diarrhea10.5
35syndromic diarrhea10.3
36hypophosphatemia10.2
37brugada syndrome10.2
38acute leukemia10.2
39diabetic ketoacidosis10.1
40quadriplegia10.1
41hyperglycemia10.1
42long qt syndrome10.1
43vipoma10.1
44celiac disease10.1
45hypoglycemia10.1
46islet cell tumor10.1
47kidney disease10.1
48hypertensive hypokalemia familial10.1
49diabetes insipidus10.0AQP2
50leptospirosis10.0PIK3C2A

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to hypokalemia

Clinical Features for Hypokalemia

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Drugs & Therapeutics for Hypokalemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypokalemia

Drug clinical trials:

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Search CenterWatch for Hypokalemia

Genetic Tests for Hypokalemia

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Anatomical Context for Hypokalemia

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32MalaCards
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MalaCards organs/tissues related to Hypokalemia:

32
Heart, Kidney, Liver, Myeloid, Lung, Pancreas, Brain, Prostate, Colon, Pituitary, B cells, Testes, Breast, Thyroid, Skeletal muscle, Eye, Spinal cord, Cortex

Animal Models for Hypokalemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypokalemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3HSD11B2, KCNJ1, CASR, BSND, PIK3C2A, REN
2MP:00053979.3CASR, MB, BSND, PIK3C2A, REN, SLC12A1
3MP:00053699.2HSD11B2, KCNH2, CACNA1S, CASR, MB, SCN4A
4MP:00053859.0MB, KCNJ1, KCNH2, HSD11B2, VIP, BSND
5MP:00053868.9CASR, CACNA1S, KCNJ1, HSD11B2, VIP, SCN4A
6MP:00053788.6MB, CASR, CACNA1S, KCNJ1, KCNH2, SCN4A
7MP:00107688.5MB, CASR, CACNA1S, KCNJ1, KCNH2, HSD11B2
8MP:00053768.4AQP2, VIP, HSD11B2, KCNH2, KCNJ1, CACNA1S

Publications for Hypokalemia

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50PubMed
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Articles related to Hypokalemia:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Thyrotoxic periodic paralysis: correct hypokalemia with caution. (23849367)
2013
2
Renal ammonia excretion in response to hypokalemia: effect of collecting duct-specific Rh C glycoprotein deletion. (23195675)
2013
3
A novel KCNQ1 splicing mutation in patients with forme fruste LQT1 aggravated by hypokalemia. (24373870)
2013
4
Sesame Oil Therapeutically Ameliorates Cardiac Hypertrophy by Regulating Hypokalemia in Hypertensive Rats. (23753993)
2013
5
ECG diagnosis: hypokalemia. (22745618)
2012
6
Unilateral paralysis associated with profound hypokalemia. (22463964)
2012
7
Attending rounds: patient with hypokalemia and metabolic acidosis. (21921151)
2011
8
A case of hypokalemia-induced fatal arrhythmia caused by indapamide in an anorexic elderly patient. (21671161)
2011
9
Hypokalemia following polyethylene glycol-based bowel preparation for colonoscopy in older hospitalized patients with significant comorbidities. (20124467)
2010
10
A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. (20338465)
2010
11
A kidney tumor in an adolescent with severe hypertension and hypokalemia: an uncommon case--case report and review of the literature on reninoma. (20453480)
2010
12
Severe life-threatening hypokalemia in a cat with suspected distal renal tubular acidosis. (20487254)
2010
13
Hypokalemia during the cooling phase of therapeutic hypothermia and its impact on arrhythmogenesis. (20828913)
2010
14
Hypokalemia and sudden cardiac death. (21264075)
2010
15
Sequential occurrence of life-threatening hypokalemia and rebound hyperkalemia associated with barbiturate coma therapy. (19281748)
2009
16
Ritodrine-induced hypokalemia. (19949616)
2009
17
The case. Hypokalemia associated with nephrocalcinosis. Distal renal tubular acidosis associated with SjAPgren's syndrome. (19180156)
2009
18
Ondansetron-associated hypokalemia in a 2-year-old with pre-B-cell ALL. (18176182)
2008
19
Myocardial necrosis related to hydrochlorothiazide-induced hypokalemia in cynomolgus monkeys. (19043288)
2008
20
A role for epinephrine in post-traumatic hypokalemia. (17414416)
2007
21
An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia. (18075291)
2007
22
A serum potassium level above 10 mmol/l in a patient predisposed to hypokalemia. (16932456)
2006
23
Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growth. (17535741)
2006
24
A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels. (16041196)
2005
25
Ziprasidone and hypokalemia: a case of 2 predisposing factors for QTc prolongation without development of torsades de pointes. (16027770)
2005
26
The cardiovascular implications of hypokalemia. (15685500)
2005
27
Central pontine and extrapontine myelinolysis associated with type 2 diabetic patient with hypokalemia. (15811568)
2005
28
Life-threatening hypokalemia in an asthmatic patient treated with high-dose hydrocortisone. (15090754)
2004
29
Disorders of potassium homeostasis. Hypokalemia and hyperkalemia. (12053834)
2002
30
Therapeutic approach to hypokalemia. (12401935)
2002
31
Studies on hypokalemia induced by trimethyltin chloride. (12046544)
2002
32
Ethnicity and unprovoked hypokalemia in the Atherosclerosis Risk in Communities Study. (12118905)
2002
33
Gitelman's syndrome: an overlooked cause of chronic hypokalemia and hypomagnesemia in adults. (11603254)
2001
34
Refractory hypokalemia in metastatic adrenocorticotrophic hormone--secreting pituitary carcinoma. (11273189)
2000
35
Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. (10818057)
2000
36
Cardiac risks of hypokalemia and hypomagnesemia]. (10894026)
2000
37
Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler. (9583400)
1998
38
Acute and chronic hypokalemia sensitize the isolated heart to hypoxic injury. (9612369)
1998
39
Hypothermia-induced hypokalemia. (9795553)
1998
40
Hypokalemia leading to torsades de pointes. Munchausen's disorder or bulimia nervosa? (9328782)
1997
41
Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. (8621781)
1996
42
Paraneoplastic hypokalemia in acute myeloid leukemia: a case of renin activity in AML blast cells. (8841102)
1996
43
Indapamide-induced severe hyponatremia and hypokalemia. (8573958)
1995
44
Neuromuscular manifestations of diarrhea related hypokalemia. (8635803)
1995
45
Concentrated potassium chloride infusions in critically ill patients with hypokalemia. (7876399)
1994
46
Hypokalemia associated with ticarcillin-clavulanic acid. (8259044)
1993
47
Renal failure and severe hypokalemia associated with acute myelomonocytic leukemia. (8372846)
1993
48
Influence of sympathetic nerve activity on ventricular arrhythmogenicity in the dog with chronic hypokalemia. (1952275)
1991
49
Persistant hypokalemia due to bilateral fibromuscular dysplasia of the renal arteries. (3516483)
1986
50
A case of watery diarrhea, hypokalemia and hypercalcemia associated with nonulcerogenic islet cell tumor of the pancreas. (174423)
1975

Genetic Variations for Hypokalemia

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Expression for genes affiliated with Hypokalemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for genes affiliated with Hypokalemia

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Hypokalemia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypokalemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5MB, VIP
2doca4410.5REN, CYP17A1, HSD11B2
3metoprolol44 28 49 11 2414.4KCNH2, REN, ADRB2
4forskolin44 49 1112.4REN, CYP17A1, HSD11B2, ADRB2
5thiazide4410.4CASR, REN, SLC12A1, SLC12A3
6bumetanide44 59 28 1113.4VIP, SLC12A1, SLC12A3
7potassium chloride44 1111.4VIP, REN, SLC12A1
8succinylcholine44 28 1112.4SCN4A, MB, PIK3C2A
9atenolol44 28 49 11 2414.4ADRB2, KCNH2, REN
10hydrochlorothiazide44 49 28 11 2414.3AQP2, HSD11B2, SLC12A3, REN, CASR
11dihydropyridine4410.3REN, CACNA1S, SCN4A
12furosemide44 49 59 28 11 2415.3SLC12A3, HSD11B2, BSND, REN, SLC12A1, AQP2
13propranolol44 28 49 11 2414.3ADRB2, KCNH2, VIP, REN
14diltiazem44 28 1112.2KCNH2, CACNA1S, REN
15corticosterone44 59 2412.2VIP, CYP17A1, HSD11B2, REN
16halothane44 28 1112.2PIK3C2A, REN, KCNH2, MB, ADRB2
17valine4410.1VIP, KCNH2, MB, SCN4A, CYP17A1
18isoproterenol44 1111.1KCNH2, VIP, ADRB2, REN, PIK3C2A
19chlorine44 2411.1SLC12A3, CLCNKB, BSND, SLC12A1
20catecholamine4410.1VIP, PIK3C2A, REN, ADRB2
21bicarbonate4410.1PIK3C2A, ATP6AP1, VIP, SLC9A3
22carvedilol44 49 28 1113.1REN, ADRB2, KCNH2
23haloperidol44 28 2 49 1114.1AQP2, REN, PIK3C2A, MB, VIP, KCNH2
24verapamil44 49 28 11 2414.1KCNH2, ADRB2, REN, CASR, VIP, CACNA1S
25sodium nitroprusside4410.0VIP, PIK3C2A, REN, MB
26acth4410.0REN, CYP17A1, HSD11B2, CASR, PIK3C2A, VIP
27epinephrine44 11 2412.0VIP, MB, PIK3C2A, ADRB2, AQP2, REN
28histidine4410.0MB, CYP17A1, SCN4A, CACNA1S, KCNH2
29pge2449.9AQP2, ADRB2, VIP, SLC12A1, REN, CASR
30prednisolone44 28 1111.9PIK3C2A, MB, VIP, HSD11B2
31hydrocortisone44 2 59 1112.9HSD11B2, REN, AQP2, SLC9A3
32dexamethasone44 49 28 1112.9HSD11B2, VIP, CYP17A1, REN, SLC9A3, AQP2
33hydrogen44 2410.8SLC9A3, KCNH2, CASR, MB, CYP17A1, ADRB2
34magnesium44 11 2411.8CASR, KCNJ1, SLC12A1, ATP1A2, PIK3C2A, AQP2
35cyclic amp44 2410.8KCNH2, ADRB2, SLC9A3, CYP17A1, CASR, VIP
36spironolactone49 44 59 28 1113.8REN, HSD11B2, KCNH2
37threonine449.8SLC12A1, CYP17A1, SLC12A3, KCNH2, ADRB2, AQP2
38nitric oxide44 11 2411.8ADRB2, AQP2, SLC9A3, SLC12A1, VIP, REN
39adenylate449.7VIP, CASR, KCNH2, MB, ADRB2, SLC9A3
40nacl449.7KCNJ1, CASR, BSND, REN, CLCNKB, SLC9A3
41glucose449.7SLC9A3, ADRB2, ATP1A2, HSD11B2, AQP2, PIK3C2A
42cysteine449.7HSD11B2, VIP, CASR, CYP17A1, MB, AQP2
43creatinine449.6MB, CASR, REN, ADRB2, KCNH2, HSD11B2
44alanine449.5ADRB2, SLC12A3, SLC9A3, PIK3C2A, VIP, KCNH2
45chloride449.4VIP, KCNJ1, CASR, SCN4A, BSND, REN
46serine449.4KCNJ1, CYP17A1, SLC9A3, SLC12A3, AQP2, MB
47arginine449.1MB, HSD11B2, KCNH2, KCNJ1, CACNA1S, VIP
48sodium44 2410.0KCNJ1, CACNA1S, CASR, SCN4A, BSND, PIK3C2A
49calcium44 49 11 2411.7ATP1A2, CYP17A1, ATP6AP1, CLCNKB, SLC9A3, SLC12A1
50potassium44 11 2410.6CLCNKB, REN, SLC9A3, SLC12A1, AQP2, ADRB2

GO Terms for genes affiliated with Hypokalemia

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16Gene Ontology
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Cellular components related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7ADRB2, SLC12A3, CLCNKB, BSND, SCN4A, CASR
2apical plasma membraneGO:0163249.6SLC9A3, SLC12A3, ADRB2, AQP2
3plasma membraneGO:0058868.6AQP2, KCNH2, KCNJ1, CACNA1S, CASR, BSND

Biological processes related to Hypokalemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:00681310.1SLC12A1, ATP1A2, KCNJ1
2sodium ion transportGO:00681410.1SLC12A3, SLC12A1, ATP1A2, SCN4A
3excretionGO:00758810.1AQP2, CLCNKB, KCNJ1
4ion transmembrane transportGO:03422010.0BSND, ATP1A2, CLCNKB, SLC12A1
5glucocorticoid biosynthetic processGO:0067049.9HSD11B2, CYP17A1
6transmembrane transportGO:0550859.8AQP2, BSND, ATP1A2, CLCNKB, SLC9A3, SLC12A1

Products for genes affiliated with Hypokalemia

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Sources for Hypokalemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet