HOKPP
MCID: HYP051
MIFTS: 62

Hypokalemic Periodic Paralysis (HOKPP) malady

Genetic diseases, Rare diseases, Muscle diseases, Metabolic diseases, Neuronal diseases categories
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Summaries for Hypokalemic Periodic Paralysis

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Genetics Home Reference:21 Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. Attacks cause severe weakness or paralysis that usually lasts from hours to days. Some people may have episodes almost every day, while others experience them weekly, monthly, or only rarely. Attacks can occur without warning or can be triggered by factors such as rest after exercise, a viral illness, or certain medications. Often, a large, carbohydrate-rich meal or vigorous exercise in the evening can trigger an attack upon waking the following morning. Although affected individuals usually regain their muscle strength between attacks, repeated episodes can lead to persistent muscle weakness later in life.

MalaCards based summary: Hypokalemic Periodic Paralysis, also known as hypopp, is related to malignant hyperthermia and normokalemic periodic paralysis. An important gene associated with Hypokalemic Periodic Paralysis is KCNJ2 (potassium inwardly-rectifying channel, subfamily J, member 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). The compounds fpl64176 and calciseptine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, thyroid and testes, and related mouse phenotypes are adipose tissue and digestive/alimentary.

NIH Rare Diseases:42 Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. most often, these episodes involve a temporary inability to move muscles in the arms and legs. the duration and frequency of the episodes may vary. hypokalemic periodic paralysis is caused by mutations in the cacna1s and scn4a genes which are inherited in an autosomal dominant fashion. a small percentage of people with the characteristic features of hypokalemic periodic paralysis do not have identified mutations in these genes. in these cases, the cause of the condition is unknown. paralytic crises can be treated with oral or iv potassium. other management includes prevention of crises and support of specific symptoms. last updated: 9/16/2009

Wikipedia:65 Hypokalemic periodic paralysis is a rare, autosomal dominant channelopathy characterized by muscle... more...

Descriptions from OMIM:46 613345,170400

GeneReviews summary for hpp

Aliases & Classifications for Hypokalemic Periodic Paralysis

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Hypokalemic Periodic Paralysis, Aliases & Descriptions:

Name: Hypokalemic Periodic Paralysis 8 19 42 21 10 44 62
Hypopp 19 42 21 62
Familial Hypokalemic Periodic Paralysis 8 21 62
Periodic Hypokalemic Paralysis 8 20 22
Familial Periodic Paralysis 8 42 62
Hokpp 19 42 21
 
Hypokalemic Familial Periodic Paralysis 8 62
Primary Hypokalemic Periodic Paralysis 21 62
Westphall Disease 21 62
Hypokpp 21 62
Periodic Paralysis I 8


Classifications:



Related Diseases for Hypokalemic Periodic Paralysis

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Diseases in the Hypokalemic Periodic Paralysis Type 1 family:

hypokalemic periodic paralysis Hypokalemic Periodic Paralysis Type 2

Diseases related to Hypokalemic Periodic Paralysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hyperthermia31.0QDPR, CACNA1S, SCN4A, RYR1
2normokalemic periodic paralysis30.9SCN4A
3hypokalemia30.9SCN4A, CACNA1S, SLC12A3, INS
4myopathy30.2INS, SCN4A, CACNA1S, CHKB, QDPR, RYR1
5renal tubular acidosis10.7
6thyrotoxicosis10.7
7hypokalemic periodic paralysis type 110.7
8hyperthyroidism10.6
9hypokalemic periodic paralysis type 210.6
10graves' disease10.6
11multiple sclerosis10.5
12thyroiditis10.5
13paramyotonia congenita10.5SCN4A
14myasthenia gravis10.4
15sjogren's syndrome10.4
16hypophosphatemia10.4
17adenoma10.4
18thyrotoxic periodic paralysis10.4
19thyrotoxic periodic paralysis 110.4
20malignant hyperthermia susceptibility10.4CACNA1S, RYR1
21central core myopathy10.3CACNA1S, RYR1
22neuroleptic malignant syndrome10.3CHKB
23familial atrial fibrillation10.3KCNE3
24westphal disease10.3
25hyperkalemic periodic paralysis type 210.3
26thomsen disease10.3SCN4A, CLCN1
27catecholaminergic polymorphic ventricular tachycardia10.3RYR1, KCNJ2
28amelogenesis imperfecta10.3
29glomerulonephritis10.3
30hepatitis10.3
31muscle disorders10.3
32membranoproliferative glomerulonephritis10.3
33hyperuricemia10.3
34wolff-parkinson-white syndrome10.3
35diabetes insipidus10.3
36gynecomastia10.3
37andersen-tawil syndrome10.3
38nephrogenic diabetes insipidus10.3
39tropical sprue10.3
40superior mesenteric artery syndrome10.3
41hyperaldosteronism10.3
42influenza10.3
43pituitary adenoma10.3
44respiratory failure10.3
45bidirectional tachycardia10.3
46growth hormone deficiency10.3
47thymic hyperplasia10.3
48myotonia10.3
49thyroid adenoma10.3
50long qt syndrome10.2CACNA1C, KCNE3, KCNJ2

Graphical network of the top 20 diseases related to Hypokalemic Periodic Paralysis:



Diseases related to hypokalemic periodic paralysis

Symptoms for Hypokalemic Periodic Paralysis

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Clinical features from OMIM:

613345,170400

Drugs & Therapeutics for Hypokalemic Periodic Paralysis

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Drug clinical trials:

Search ClinicalTrials for Hypokalemic Periodic Paralysis

Search NIH Clinical Center for Hypokalemic Periodic Paralysis

Genetic Tests for Hypokalemic Periodic Paralysis

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Genetic tests related to Hypokalemic Periodic Paralysis:

id Genetic test Affiliating Genes
1 Hypokalemic Periodic Paralysis20 22 SCN4A

Anatomical Context for Hypokalemic Periodic Paralysis

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MalaCards organs/tissues related to Hypokalemic Periodic Paralysis:

32
Skeletal muscle, Thyroid, Testes, Pituitary

Animal Models for Hypokalemic Periodic Paralysis or affiliated genes

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MGI Mouse Phenotypes related to Hypokalemic Periodic Paralysis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9RYR1, CACNA1S, INS, KCNJ12
2MP:00053818.7RYR1, INS, KCNE3, KCNJ2, CACNA1S
3MP:00053908.3RYR1, KCNJ2, INS, CLCN1, CHKB, CACNA1S
4MP:00053697.8CLCN1, SCN4A, INS, KCNJ2, ABCC9, CHKB
5MP:00053857.5ABCC9, KCNJ12, KCNJ2, INS, CACNA1D, CACNA1C
6MP:00107687.5RYR1, CACNA1D, CACNA1S, CLCN1, SCN4A, INS
7MP:00053867.4RYR1, CACNA1C, CACNA1D, CHKB, CLCN1, SCN4A
8MP:00053787.4ABCC9, KCNJ12, INS, SCN4A, CLCN1, CACNA1S
9MP:00053766.4CLCN1, KCNJ12, ABCC9, KCNE3, CACNA1C, SLC12A3

Publications for Hypokalemic Periodic Paralysis

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Articles related to Hypokalemic Periodic Paralysis:

(show top 50)    (show all 269)
idTitleAuthorsYear
1
Possible brugada phenocopy induced by hypokalemia in a patient with congenital hypokalemic periodic paralysis. (24652091)
2014
2
Thyrotoxic, hypokalemic periodic paralysis (THPP) in adolescents. (25153560)
2014
3
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
4
Thyrotoxic hypokalemic periodic paralysis as the presenting symptom of silent thyroiditis. (23956568)
2013
5
V876E mutation in CACNA1S gene associated with severe hypokalemic periodic paralysis in a Chinese woman. (23948435)
2013
6
Thyrotoxic hypokalemic periodic paralysis: two case reports and a brief review of literature. (24156178)
2013
7
Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis. (23953801)
2013
8
A novel mutation in the calcium channel gene in a family with hypokalemic periodic paralysis. (21855088)
2011
9
Hypokalemic periodic paralysis due to proximal renal tubular acidosis in a case with membranoproliferative glomerulonephritis. (22616344)
2011
10
Hypokalemic periodic paralysis: a case series, review of the literature and update of management. (20201128)
2010
11
Pot paresis: marijuana and a case of hypokalemic periodic paralysis. (17976782)
2009
12
Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency. (17556873)
2007
13
Absence of ion channels CACN1AS and SCN4A mutations in thyrotoxic hypokalemic periodic paralysis. (15072700)
2004
14
Thyrotropin-secreting pituitary adenoma presenting as hypokalemic periodic paralysis. (12544087)
2003
15
Sodium channel gene mutations in hypokalemic periodic paralysis: an uncommon cause in the UK. (11591859)
2001
16
A case of familial hypokalemic periodic paralysis with hyperuricemia during paralytic attack and genetic analysis of the pedigree]. (11808349)
2001
17
Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. (10944223)
2000
18
Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. (10976636)
2000
19
Bilateral vocal fold paralysis caused by familial hypokalemic periodic paralysis. (10229618)
1999
20
Thyrotoxic hypokalemic periodic paralysis: six cases in non-Asian patients. (15251742)
1998
21
Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H. (9852570)
1998
22
Nonfamilial hypokalemic periodic paralysis and thyrotoxicosis in a 16-year-old male. (9282719)
1997
23
Mutation analysis of the CACNL1A3 gene in Japanese hypokalemic periodic paralysis families]. (9436445)
1997
24
Hypokalemic periodic paralysis: an unusual cause. (9251321)
1996
25
Trismus associated with hypokalemic periodic paralysis. (9251437)
1996
26
Renal tubular acidosis complicated with hypokalemic periodic paralysis. (7575850)
1995
27
Familial hypokalemic periodic paralysis. Clinical, diagnostic and therapeutic aspects. (8195801)
1994
28
Primary hypokalemic periodic paralysis. (7896370)
1994
29
Thyrotoxic hypokalemic periodic paralysis: report of four cases in black American males. (7711509)
1994
30
Thyrotoxic hypokalemic periodic paralysis following second-trimester prostaglandin-induced abortion. (8378017)
1993
31
SjAPgren's syndrome presenting as hypokalemic periodic paralysis. (8250993)
1993
32
Muscle fiber conduction velocity in the diagnosis of sporadic hypokalemic periodic paralysis. (1324813)
1992
33
Diagnosis of familial hypokalemic periodic paralysis: role of the potassium exercise test. (1436528)
1992
34
Muscle pathology correlates with permanent weakness in hypokalemic periodic paralysis: a case report. (1381862)
1992
35
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
36
Sudden deafness in a man with thyrotoxic hypokalemic periodic paralysis. (3193664)
1988
37
Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis. (3287913)
1988
38
Thyrotoxic hypokalemic periodic paralysis: report of four cases and review of the literature (1). (3819899)
1987
39
Hormonal changes during a spontaneous attack of hypokalemic periodic paralysis. (3028812)
1987
40
Thyrotoxic hypokalemic periodic paralysis: report of four cases and review of the literature (2). (3550012)
1987
41
Generalized epilepsy in a patient with hypokalemic periodic paralysis and cardiac arrhythmia. (6865105)
1983
42
Familial hypokalemic periodic paralysis in blacks. (7129944)
1982
43
Hypokalemic periodic paralysis associated with multiple sclerosis. (7398686)
1980
44
Erythrocyte membrane studies in familial hypokalemic periodic paralysis. (150837)
1978
45
Speculations on hypokalemic periodic paralysis. (4742367)
1973
46
Acetazolamide treatment in hypokalemic periodic paralysis: a metabolic and electromyographic study. (4742365)
1973
47
Ultrastructural changes in hypokalemic periodic paralysis. (4334608)
1971
48
The histographic analysis of human muscle biopsies with regard to fiber types. 3. Myotonias, myasthenia gravis, and hypokalemic periodic paralysis. (5815221)
1969
49
The sarcoplasmic reticulum in thyrotoxic hypokalemic periodic paralysis. (5766391)
1969
50
Light and electron microscopic study of the muscles in hypokalemic periodic paralysis. (5806345)
1969

Variations for Hypokalemic Periodic Paralysis

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Clinvar genetic disease variations for Hypokalemic Periodic Paralysis:

6
id Gene Name Type Significance SNP ID Assembly Location
1KCNJ2NM_000891.2(KCNJ2): c.161G> T (p.Cys54Phe)single nucleotide variantPathogenicrs199473650GRCh37Chr 17, 68171341: 68171341

Expression for genes affiliated with Hypokalemic Periodic Paralysis

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Expression patterns in normal tissues for genes affiliated with Hypokalemic Periodic Paralysis

Search GEO for disease gene expression data for Hypokalemic Periodic Paralysis.

Pathways for genes affiliated with Hypokalemic Periodic Paralysis

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Pathways related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CACNA1C, CACNA1D
29.7CACNA1D, CACNA1C
3
Show member pathways
Alzheimers Disease37
9.7CACNA1D, CACNA1C
4
Show member pathways
aspartate biosynthesis37
9.7CACNA1C, CACNA1D
59.6SCN4A, SCN7A
69.5CACNA1C, CACNA1D, CACNA1S
7
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.5CACNA1C, CACNA1D, CACNA1S
89.5CACNA1C, CACNA1D, CACNA1S
9
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
10
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
11
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
129.5CACNA1C, CACNA1D, CACNA1S
13
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.5CACNA1C, CACNA1D, CACNA1S
149.5CACNA1S, CACNA1D, CACNA1C
15
Show member pathways
9.5CACNA1S, CACNA1D, CACNA1C
16
Show member pathways
9.5CACNA1S, CACNA1D, CACNA1C
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.5CACNA1S, CACNA1D, CACNA1C
18
Show member pathways
9.3KCNJ2, KCNJ12, ABCC9
199.2CACNA1S, CACNA1D, CACNA1C, RYR1
20
Show member pathways
9.2CACNA1S, CACNA1D, CACNA1C, RYR1
21
Show member pathways
Calcium Regulation in the Cardiac Cell37
9.2RYR1, CACNA1C, CACNA1D, CACNA1S
229.2CACNA1S, CACNA1D, CACNA1C, RYR1
239.2CACNA1S, CACNA1D, CACNA1C, RYR1
24
Show member pathways
9.2CACNA1C, CACNA1D, INS
25
Show member pathways
9.2CACNA1C, CACNA1D, INS
26
Show member pathways
9.1ABCC9, KCNJ12, KCNJ2, KCNE3
27
Show member pathways
9.1ABCC9, CLCN1, SLC12A3, RYR1
28
Show member pathways
9.0CACNA1C, CACNA1D, CACNA1S, INS
29
Show member pathways
9.0CACNA1C, CACNA1D, CACNA1S, INS
30
Show member pathways
8.9CACNA1S, CACNA1D, CACNA1C, QDPR, RYR1
31
Show member pathways
8.9SCN7A, SCN4A, CLCN1, SLC12A3
328.9SCN7A, CACNA1S, CACNA1D, CACNA1C
338.9CACNA1C, CACNA1D, KCNE3, KCNJ2, ABCC9
34
Show member pathways
8.7RYR1, CACNA1C, CACNA1D, CACNA1S, INS
35
Show member pathways
8.6SCN7A, SCN4A, CACNA1S, CACNA1D, CACNA1C
36
Show member pathways
8.6INS, CLCN1, CACNA1S, CACNA1D, CACNA1C
378.5KCNJ12, KCNJ2, KCNE3, CACNA1S, CACNA1D, CACNA1C
38
Show member pathways
8.5KCNJ12, KCNJ2, CACNA1S, CACNA1D, CACNA1C, RYR1
39
Show member pathways
8.5CACNA1D, CACNA1S, KCNJ2, KCNJ12, CACNA1C, RYR1
40
Show member pathways
8.1INS, SCN7A, SCN4A, CACNA1S, CACNA1D, CACNA1C
41
Show member pathways
8.0SCN7A, SCN4A, CLCN1, CACNA1S, CACNA1D, CACNA1C

Compounds for genes affiliated with Hypokalemic Periodic Paralysis

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Compounds related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fpl641762810.3CACNA1S, CACNA1C
2calciseptine2810.3CACNA1S, CACNA1C
3sz(+)-(s)-202-7912810.3CACNA1S, CACNA1C
4dantrolene28 44 1112.1RYR1, CHKB
5mgadp4410.0ABCC9, CHKB
6ryanodine44 28 6112.0RYR1, QDPR, CACNA1S
7diltiazem44 28 50 1113.0CHKB, CACNA1S, CACNA1C
8[3h](+)-isradipine289.9CACNA1C, CACNA1D, CACNA1S
9(-)-(s)-bayk8644289.9CACNA1S, CACNA1D, CACNA1C
10tertiapin-q619.9KCNJ2, KCNJ12
11nisoldipine28 44 1111.9CACNA1S, CACNA1D, CACNA1C
12(+-)-bay k 8644619.9CACNA1S, CACNA1D, CACNA1C
13nnc 55-0396 dihydrochloride619.9CACNA1S, CACNA1D, CACNA1C
14mibefradil dihydrochloride619.9CACNA1S, CACNA1D, CACNA1C
15omega-conotoxin gvia61 2810.9CACNA1S, CACNA1D, CACNA1C
16pregabalin61 44 1111.9CACNA1S, CACNA1D, CACNA1C
17isradipine44 28 1111.9CACNA1C, CACNA1D, CACNA1S
18nilvadipine44 1110.9CACNA1C, CACNA1D, CACNA1S
19levcromakalim619.9KCNJ2, KCNJ12
20lead449.9CHKB, QDPR, RYR1
21nimodipine44 28 1111.9CACNA1C, CACNA1D, CACNA1S
22nitrendipine44 50 28 1112.9CACNA1S, CACNA1D, CACNA1C
23felodipine44 28 1111.9CACNA1C, CACNA1D, CACNA1S
24mibefradil44 28 1111.9CACNA1C, CACNA1D, CACNA1S
25succinylcholine44 50 28 1112.9SCN4A, CHKB, CACNA1S, RYR1
26meglitinide449.9ABCC9, INS
27mg2+289.9KCNJ12, KCNJ2, RYR1
28p1075619.9KCNJ2, KCNJ12
29amlodipine44 50 24 1112.8CACNA1S, CACNA1D, CACNA1C
30beta-hydroxybutyrate449.8INS, CHKB
31mgatp449.8ABCC9, CHKB, RYR1
32chlorine44 2410.8SLC12A3, CLCN1, KCNE3
33verapamil44 28 50 24 1113.7CACNA1C, CACNA1D, CACNA1S
34dihydropyridine449.6SCN4A, CACNA1S, CACNA1C, QDPR, RYR1
35thiazide449.6SLC12A3, INS
36chloride449.6RYR1, SLC12A3, CLCN1, SCN4A
37gliclazide44 50 1111.5INS, ABCC9
38niflumic acid44 28 1111.5CLCN1, RYR1
39glimepiride44 50 1111.4ABCC9, INS
40tacrolimus44 50 1111.4INS, CHKB, QDPR, RYR1
41norepinephrine44 24 1111.4RYR1, QDPR, CHKB, INS
42nifedipine44 28 50 1112.4CACNA1S, CACNA1D, CACNA1C, QDPR, RYR1
43glibenclamide44 28 50 6112.2ABCC9, KCNJ12, KCNJ2, INS
44atp44 2810.0ABCC9, SCN4A, CHKB, QDPR, RYR1
45arginine449.0KCNJ2, INS, SCN4A, CHKB, CACNA1S, RYR1
46alanine449.0INS, CHKB, SLC12A3, QDPR, RYR1
47diazoxide44 61 28 1111.9SLC12A3, INS, KCNJ2, KCNJ12, ABCC9
48sodium44 249.6SCN7A, SCN4A, CLCN1, CACNA1S, CACNA1D, SLC12A3
49potassium44 24 1110.4RYR1, ABCC9, KCNJ12, KCNJ2, KCNE3, SCN4A
50calcium44 50 24 1110.7KCNJ2, SCN7A, SCN4A, CHKB, CACNA1S, CACNA1D

GO Terms for genes affiliated with Hypokalemic Periodic Paralysis

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Cellular components related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1smooth endoplasmic reticulumGO:00579010.0RYR1, KCNJ2
2sarcoplasmic reticulumGO:01652910.0RYR1, CACNA1S
3T-tubuleGO:0303159.9KCNJ2, CACNA1S, RYR1
4I bandGO:0316749.9CACNA1S, RYR1
5intrinsic component of membraneGO:0312249.9KCNJ2, KCNJ12
6voltage-gated calcium channel complexGO:0058919.7CACNA1C, CACNA1D, CACNA1S
7voltage-gated sodium channel complexGO:0015189.6SCN4A, SCN7A
8integral component of plasma membraneGO:0058878.7RYR1, SLC12A3, CLCN1, SCN4A, KCNJ2
9plasma membraneGO:0058867.3RYR1, ABCC9, KCNJ12, KCNJ2, KCNJ18, CLCN1

Biological processes related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1potassium ion importGO:01010710.1KCNJ2, ABCC9
2membrane depolarization during cardiac muscle cell action potentialGO:08601210.0CACNA1D, KCNJ2
3skeletal muscle fiber developmentGO:0487419.9RYR1, CACNA1S
4potassium ion transmembrane transportGO:0718059.7KCNJ18, KCNJ2, KCNJ12
5calcium ion transportGO:0068169.7RYR1, CACNA1D, CACNA1S
6sodium ion transportGO:0068149.5SCN7A, SCN4A, SLC12A3
7regulation of heart rate by cardiac conductionGO:0860919.5KCNJ2, CACNA1D
8potassium ion transportGO:0068139.5ABCC9, KCNJ12, KCNJ2
9regulation of insulin secretionGO:0507969.3CACNA1C, CACNA1D, INS
10energy reserve metabolic processGO:0061129.3CACNA1C, CACNA1D, INS
11transmembrane transportGO:0550859.1RYR1, SLC12A3, CLCN1, ABCC9
12synaptic transmissionGO:0072689.0ABCC9, KCNJ12, KCNJ2, CACNA1C
13muscle contractionGO:0069368.5RYR1, KCNJ12, SCN7A, SCN4A, CLCN1, CACNA1S

Molecular functions related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.8KCNE3, ABCC9
2alpha-actinin bindingGO:0513939.6CACNA1C, CACNA1D
3high voltage-gated calcium channel activityGO:0083319.6CACNA1C, CACNA1D, CACNA1S
4inward rectifier potassium channel activityGO:0052429.5KCNJ12, KCNJ2, KCNJ18
5voltage-gated sodium channel activityGO:0052489.3SCN4A, SCN7A
6voltage-gated calcium channel activityGO:0052459.3RYR1, CACNA1C, CACNA1D, CACNA1S

Products for genes affiliated with Hypokalemic Periodic Paralysis

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Sources for Hypokalemic Periodic Paralysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet