HOKPP
MCID: HYP051
MIFTS: 61

Hypokalemic Periodic Paralysis (HOKPP) malady

Genetic diseases, Rare diseases, Muscle diseases, Neuronal diseases categories

Summaries for Hypokalemic Periodic Paralysis

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44NIH Rare Diseases, 66Wikipedia, 48OMIM, 20GeneReviews, 34MalaCards
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NIH Rare Diseases:44 Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. most often, these episodes involve a temporary inability to move muscles in the arms and legs. the duration and frequency of the episodes may vary. hypokalemic periodic paralysis is caused by mutations in the cacna1s and scn4a genes which are inherited in an autosomal dominant fashion. a small percentage of people with the characteristic features of hypokalemic periodic paralysis do not have identified mutations in these genes. in these cases, the cause of the condition is unknown.Ā paralytic crisesĀ can beĀ treated with oral or iv potassium. other management includes prevention of crises and support of specific symptoms. last updated: 9/16/2009

MalaCards: Hypokalemic Periodic Paralysis, also known as periodic hypokalemic paralysis, is related to malignant hyperthermia and myopathy. An important gene associated with Hypokalemic Periodic Paralysis is SCN4A (sodium channel, voltage-gated, type IV, alpha subunit), and among its related pathways are Alzheimer's disease and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). The compounds fpl64176 and calciseptine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, thyroid and testes, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:66 Hypokalemic periodic paralysis is a rare, autosomal dominant channelopathy characterized by muscle... more...

Description from OMIM:48 170400,613345

GeneReviews summary for hpp

Aliases & Classifications for Hypokalemic Periodic Paralysis

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9Disease Ontology, 20GeneReviews, 44NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 48OMIM, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Muscle diseases, Neuronal diseases


Aliases & Descriptions:

hypokalemic periodic paralysis 9 20 44 22 11 46 63
periodic hypokalemic paralysis 9 21 23
familial periodic paralysis 9 44 63
hypopp 20 44 22
hokpp 20 44 22
familial hypokalemic periodic paralysis 9 22
hypokalemic familial periodic paralysis 9
primary hypokalemic periodic paralysis 22
periodic paralysis i 9
westphall disease 22
hypokpp 22


Related Diseases for Hypokalemic Periodic Paralysis

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18GeneCards, 19GeneDecks
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Diseases in the Hypokalemic Periodic Paralysis Type 1 family:

hypokalemic periodic paralysis Hypokalemic Periodic Paralysis Type 2

Diseases related to Hypokalemic Periodic Paralysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hyperthermia30.8RYR1, QDPR, CACNA1S, SCN4A
2myopathy30.7INS, SCN4A, CLCN1, CHKB, CACNA1S, QDPR
3hypokalemia30.6INS, SCN4A, CACNA1S, SLC12A3
4normokalemic periodic paralysis30.3SCN4A
5renal tubular acidosis10.7
6thyrotoxicosis10.7
7hypokalemic periodic paralysis type 110.7
8hyperthyroidism10.6
9hypokalemic periodic paralysis type 210.6
10graves' disease10.6
11multiple sclerosis10.5
12thyroiditis10.5
13sjogren's syndrome10.4
14hypophosphatemia10.4
15adenoma10.4
16myasthenia gravis10.4
17thyrotoxic periodic paralysis10.4
18thyrotoxic periodic paralysis 110.4
19westphal disease10.3
20hyperkalemic periodic paralysis type 210.3
21hyperuricemia10.3
22wolff-parkinson-white syndrome10.3
23membranoproliferative glomerulonephritis10.3
24diabetes insipidus10.3
25amelogenesis imperfecta10.3
26tropical sprue10.3
27gynecomastia10.3
28andersen-tawil syndrome10.3
29superior mesenteric artery syndrome10.3
30nephrogenic diabetes insipidus10.3
31hypophosphatasia10.3
32glomerulonephritis10.3
33hepatitis10.3
34hyperaldosteronism10.3
35influenza10.3
36pituitary adenoma10.3
37respiratory failure10.3
38hypomyelination and congenital cataract10.3
39bidirectional tachycardia10.3
40growth hormone deficiency10.3
41thymic hyperplasia10.3
42myotonia10.3
43thyroid adenoma10.3
44waardenburg's syndrome10.1
45infectious mononucleosis10.1
46charcot-marie-tooth disease10.1
47tooth disease10.1
48familial periodic paralyses10.1
49periodic paralyses10.1
50paramyotonia congenita10.1SCN4A

Graphical network of the top 20 diseases related to Hypokalemic Periodic Paralysis:



Diseases related to hypokalemic periodic paralysis

Symptoms for Hypokalemic Periodic Paralysis

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48OMIM
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Clinical features from OMIM:

170400,613345

Drugs & Therapeutics for Hypokalemic Periodic Paralysis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hypokalemic Periodic Paralysis

Drug clinical trials:

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Search NIH Clinical Center for Hypokalemic Periodic Paralysis

Search CenterWatch for Hypokalemic Periodic Paralysis

Genetic Tests for Hypokalemic Periodic Paralysis

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21GeneTests, 23GTR
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Genetic tests related to Hypokalemic Periodic Paralysis:

id Genetic test Affiliating Genes
1 Hypokalemic Periodic Paralysis21 23 SCN4A

Anatomical Context for Hypokalemic Periodic Paralysis

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34MalaCards
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MalaCards organs/tissues related to Hypokalemic Periodic Paralysis:

34
Skeletal muscle, Thyroid, Testes, Pituitary

Animal Models for Hypokalemic Periodic Paralysis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hypokalemic Periodic Paralysis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9RYR1, CACNA1S, INS, KCNJ12
2MP:00053818.6KCNJ2, KCNE3, INS, CACNA1S, RYR1
3MP:00053908.3KCNJ2, INS, CLCN1, CHKB, CACNA1S, QDPR
4MP:00053697.8RYR1, ABCC9, KCNJ2, INS, SCN4A, CLCN1
5MP:00053857.5ABCC9, KCNJ12, KCNJ2, INS, CACNA1D, CACNA1C
6MP:00053867.4KCNJ12, INS, SCN4A, CLCN1, CHKB, CACNA1S
7MP:00107687.4ABCC9, KCNJ2, INS, SCN4A, CLCN1, CACNA1S
8MP:00053787.4ABCC9, KCNJ12, INS, SCN4A, CLCN1, CACNA1S
9MP:00053766.4INS, KCNE3, KCNJ2, KCNJ12, ABCC9, CLCN1

Publications for Hypokalemic Periodic Paralysis

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53PubMed
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Articles related to Hypokalemic Periodic Paralysis:

(show top 50)    (show all 264)
idTitleAuthorsYear
1
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
2
Thyrotoxic hypokalemic periodic paralysis as the presenting symptom of silent thyroiditis. (23956568)
2013
3
V876E mutation in CACNA1S gene associated with severe hypokalemic periodic paralysis in a Chinese woman. (23948435)
2013
4
Thyrotoxic hypokalemic periodic paralysis: two case reports and a brief review of literature. (24156178)
2013
5
Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis. (23953801)
2013
6
A novel mutation in the calcium channel gene in a family with hypokalemic periodic paralysis. (21855088)
2011
7
Hypokalemic periodic paralysis due to proximal renal tubular acidosis in a case with membranoproliferative glomerulonephritis. (22616344)
2011
8
Hypokalemic periodic paralysis: a case series, review of the literature and update of management. (20201128)
2010
9
Pot paresis: marijuana and a case of hypokalemic periodic paralysis. (17976782)
2009
10
Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency. (17556873)
2007
11
Absence of ion channels CACN1AS and SCN4A mutations in thyrotoxic hypokalemic periodic paralysis. (15072700)
2004
12
Thyrotropin-secreting pituitary adenoma presenting as hypokalemic periodic paralysis. (12544087)
2003
13
Sodium channel gene mutations in hypokalemic periodic paralysis: an uncommon cause in the UK. (11591859)
2001
14
A case of familial hypokalemic periodic paralysis with hyperuricemia during paralytic attack and genetic analysis of the pedigree]. (11808349)
2001
15
Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. (10944223)
2000
16
Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. (10976636)
2000
17
Bilateral vocal fold paralysis caused by familial hypokalemic periodic paralysis. (10229618)
1999
18
Thyrotoxic hypokalemic periodic paralysis: six cases in non-Asian patients. (15251742)
1998
19
Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H. (9852570)
1998
20
Nonfamilial hypokalemic periodic paralysis and thyrotoxicosis in a 16-year-old male. (9282719)
1997
21
Mutation analysis of the CACNL1A3 gene in Japanese hypokalemic periodic paralysis families]. (9436445)
1997
22
Identification of mutations in the CACNL1A3 gene in 13 families of Scandinavian origin having hypokalemic periodic paralysis and evidence of a founder effect in Danish families. (9066893)
1997
23
Hypokalemic periodic paralysis: an unusual cause. (9251321)
1996
24
Trismus associated with hypokalemic periodic paralysis. (9251437)
1996
25
Renal tubular acidosis complicated with hypokalemic periodic paralysis. (7575850)
1995
26
Familial hypokalemic periodic paralysis. Clinical, diagnostic and therapeutic aspects. (8195801)
1994
27
Primary hypokalemic periodic paralysis. (7896370)
1994
28
Thyrotoxic hypokalemic periodic paralysis: report of four cases in black American males. (7711509)
1994
29
Thyrotoxic hypokalemic periodic paralysis following second-trimester prostaglandin-induced abortion. (8378017)
1993
30
SjAPgren's syndrome presenting as hypokalemic periodic paralysis. (8250993)
1993
31
Muscle fiber conduction velocity in the diagnosis of sporadic hypokalemic periodic paralysis. (1324813)
1992
32
Diagnosis of familial hypokalemic periodic paralysis: role of the potassium exercise test. (1436528)
1992
33
Muscle pathology correlates with permanent weakness in hypokalemic periodic paralysis: a case report. (1381862)
1992
34
Hyperthyroid hypokalemic periodic paralysis in a Hispanic male. (2304102)
1990
35
Hypokalemic periodic paralysis due to the SjAPgren syndrome in Chinese patients. (2916810)
1989
36
Sudden deafness in a man with thyrotoxic hypokalemic periodic paralysis. (3193664)
1988
37
Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis. (3287913)
1988
38
Thyrotoxic hypokalemic periodic paralysis: report of four cases and review of the literature (1). (3819899)
1987
39
Hormonal changes during a spontaneous attack of hypokalemic periodic paralysis. (3028812)
1987
40
Thyrotoxic hypokalemic periodic paralysis: report of four cases and review of the literature (2). (3550012)
1987
41
Generalized epilepsy in a patient with hypokalemic periodic paralysis and cardiac arrhythmia. (6865105)
1983
42
Familial hypokalemic periodic paralysis in blacks. (7129944)
1982
43
Hypokalemic periodic paralysis associated with multiple sclerosis. (7398686)
1980
44
Erythrocyte membrane studies in familial hypokalemic periodic paralysis. (150837)
1978
45
Speculations on hypokalemic periodic paralysis. (4742367)
1973
46
Acetazolamide treatment in hypokalemic periodic paralysis: a metabolic and electromyographic study. (4742365)
1973
47
Ultrastructural changes in hypokalemic periodic paralysis. (4334608)
1971
48
The histographic analysis of human muscle biopsies with regard to fiber types. 3. Myotonias, myasthenia gravis, and hypokalemic periodic paralysis. (5815221)
1969
49
The sarcoplasmic reticulum in thyrotoxic hypokalemic periodic paralysis. (5766391)
1969
50
Light and electron microscopic study of the muscles in hypokalemic periodic paralysis. (5806345)
1969

Variations for Hypokalemic Periodic Paralysis

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Hypokalemic Periodic Paralysis:

1
id Gene Name Type Significance SNP ID Assembly Location
1KCNJ2NM_000891.2(KCNJ2): c.161G> T (p.Cys54Phe)single nucleotide variantPathogenicrs199473650GRCh37Chr 17, 68171341: 68171341

Expression for genes affiliated with Hypokalemic Periodic Paralysis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypokalemic Periodic Paralysis

Search GEO for disease gene expression data for Hypokalemic Periodic Paralysis.

Pathways for genes affiliated with Hypokalemic Periodic Paralysis

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore
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Pathways related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Alzheimers Disease39
9.7CACNA1D, CACNA1C
29.7CACNA1D, CACNA1C
39.7CACNA1C, CACNA1D
4
Show member pathways
aspartate biosynthesis39
9.7CACNA1C, CACNA1D
59.6SCN4A, SCN7A
69.5CACNA1C, CACNA1D, CACNA1S
7
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.5CACNA1C, CACNA1D, CACNA1S
8
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
9
Show member pathways
9.5CACNA1S, CACNA1D, CACNA1C
10
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
11
Show member pathways
9.5CACNA1C, CACNA1D, CACNA1S
129.5CACNA1S, CACNA1D, CACNA1C
13
Show member pathways
Development Ligand independent activation of ESR1 and ESR261
9.5CACNA1S, CACNA1D, CACNA1C
149.5CACNA1C, CACNA1D, CACNA1S
159.5CACNA1C, CACNA1D, CACNA1S
16
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.5CACNA1C, CACNA1D, CACNA1S
17
Show member pathways
9.5CACNA1S, CACNA1D, CACNA1C
189.2CACNA1S, CACNA1D, CACNA1C, RYR1
199.2CACNA1S, CACNA1D, CACNA1C, RYR1
209.2CACNA1S, CACNA1D, CACNA1C, RYR1
21
Show member pathways
9.2CACNA1S, CACNA1D, CACNA1C, RYR1
22
Show member pathways
Calcium Regulation in the Cardiac Cell39
9.2RYR1, CACNA1C, CACNA1D, CACNA1S
23
Show member pathways
9.2KCNJ2, KCNJ12, ABCC9
24
Show member pathways
9.2CACNA1C, CACNA1D, INS
25
Show member pathways
9.2CACNA1C, CACNA1D, INS
26
Show member pathways
9.1ABCC9, CLCN1, SLC12A3, RYR1
27
Show member pathways
9.0ABCC9, KCNJ12, KCNJ2, KCNE3
28
Show member pathways
9.0CACNA1C, CACNA1D, CACNA1S, INS
29
Show member pathways
9.0CACNA1C, CACNA1D, CACNA1S, INS
30
Show member pathways
9.0CACNA1S, CACNA1D, CACNA1C, QDPR, RYR1
31
Show member pathways
8.9SCN7A, SCN4A, CLCN1, SLC12A3
328.9SCN7A, CACNA1S, CACNA1D, CACNA1C
338.8CACNA1C, CACNA1D, KCNE3, KCNJ2, ABCC9
34
Show member pathways
8.7RYR1, CACNA1C, CACNA1D, CACNA1S, INS
35
Show member pathways
8.7SCN7A, SCN4A, CACNA1S, CACNA1D, CACNA1C
36
Show member pathways
8.6INS, CLCN1, CACNA1S, CACNA1D, CACNA1C
378.5KCNJ12, KCNJ2, KCNE3, CACNA1S, CACNA1D, CACNA1C
38
Show member pathways
8.4KCNJ12, KCNJ2, CACNA1S, CACNA1D, CACNA1C, RYR1
39
Show member pathways
8.4CACNA1D, CACNA1S, KCNJ2, KCNJ12, CACNA1C, RYR1
40
Show member pathways
8.2INS, SCN7A, SCN4A, CACNA1S, CACNA1D, CACNA1C
41
Show member pathways
8.0SCN7A, SCN4A, CLCN1, CACNA1S, CACNA1D, CACNA1C

Compounds for genes affiliated with Hypokalemic Periodic Paralysis

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30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1fpl641763010.3CACNA1S, CACNA1C
2calciseptine3010.3CACNA1S, CACNA1C
3sz(+)-(s)-202-7913010.3CACNA1S, CACNA1C
4dantrolene30 46 1212.2RYR1, CHKB
5mgadp4610.0ABCC9, CHKB
6ryanodine46 30 6212.0RYR1, QDPR, CACNA1S
7diltiazem46 30 52 1213.0CHKB, CACNA1S, CACNA1C
8[3h](+)-isradipine3010.0CACNA1C, CACNA1D, CACNA1S
9(-)-(s)-bayk86443010.0CACNA1S, CACNA1D, CACNA1C
10nisoldipine30 46 1211.9CACNA1S, CACNA1D, CACNA1C
11(+-)-bay k 8644629.9CACNA1S, CACNA1D, CACNA1C
12nnc 55-0396 dihydrochloride629.9CACNA1S, CACNA1D, CACNA1C
13mibefradil dihydrochloride629.9CACNA1S, CACNA1D, CACNA1C
14omega-conotoxin gvia62 3010.9CACNA1S, CACNA1D, CACNA1C
15pregabalin62 46 1211.9CACNA1S, CACNA1D, CACNA1C
16isradipine46 30 1211.9CACNA1C, CACNA1D, CACNA1S
17nilvadipine46 1210.9CACNA1C, CACNA1D, CACNA1S
18lead469.9CHKB, QDPR, RYR1
19nimodipine46 30 1211.9CACNA1C, CACNA1D, CACNA1S
20nitrendipine46 52 30 1212.9CACNA1S, CACNA1D, CACNA1C
21felodipine46 30 1211.9CACNA1C, CACNA1D, CACNA1S
22succinylcholine46 52 30 1212.9SCN4A, CHKB, CACNA1S, RYR1
23mibefradil46 30 1211.9CACNA1C, CACNA1D, CACNA1S
24amlodipine46 52 25 1212.9CACNA1S, CACNA1D, CACNA1C
25meglitinide469.9ABCC9, INS
26beta-hydroxybutyrate469.8INS, CHKB
27tertiapin-q629.8KCNJ2, KCNJ12
28mgatp469.8ABCC9, CHKB, RYR1
29levcromakalim629.8KCNJ2, KCNJ12
30mg2+309.8KCNJ12, KCNJ2, RYR1
31chlorine46 2510.8SLC12A3, CLCN1, KCNE3
32p1075629.8KCNJ2, KCNJ12
33verapamil46 30 52 25 1213.7CACNA1C, CACNA1D, CACNA1S
34dihydropyridine469.7SCN4A, CACNA1S, CACNA1C, QDPR, RYR1
35thiazide469.6SLC12A3, INS
36chloride469.6RYR1, SLC12A3, CLCN1, SCN4A
37gliclazide46 52 1211.5INS, ABCC9
38niflumic acid46 30 1211.5CLCN1, RYR1
39tacrolimus46 52 1211.4INS, CHKB, QDPR, RYR1
40glimepiride46 52 1211.4ABCC9, INS
41nifedipine46 30 52 1212.4CACNA1S, CACNA1D, CACNA1C, QDPR, RYR1
42norepinephrine46 25 1211.4RYR1, QDPR, CHKB, INS
43glibenclamide46 30 52 6212.2ABCC9, KCNJ12, KCNJ2, INS
44atp46 3010.1ABCC9, SCN4A, CHKB, QDPR, RYR1
45alanine469.0INS, CHKB, SLC12A3, QDPR, RYR1
46arginine469.0KCNJ2, INS, SCN4A, CHKB, CACNA1S, RYR1
47diazoxide46 62 30 1211.8SLC12A3, INS, KCNJ2, KCNJ12, ABCC9
48sodium46 259.7SCN7A, SCN4A, CLCN1, CACNA1S, CACNA1D, SLC12A3
49potassium46 25 1210.3RYR1, ABCC9, KCNJ12, KCNJ2, KCNE3, SCN4A
50calcium46 52 25 1210.6KCNJ2, SCN7A, SCN4A, CHKB, CACNA1S, CACNA1D

GO Terms for genes affiliated with Hypokalemic Periodic Paralysis

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17Gene Ontology
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Cellular components related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcoplasmic reticulumGO:01652910.0RYR1, CACNA1S
2smooth endoplasmic reticulumGO:00579010.0RYR1, KCNJ2
3I bandGO:0316749.9CACNA1S, RYR1
4T-tubuleGO:0303159.8KCNJ2, CACNA1S, RYR1
5intrinsic component of membraneGO:0312249.8KCNJ2, KCNJ12
6voltage-gated calcium channel complexGO:0058919.7CACNA1C, CACNA1D, CACNA1S
7voltage-gated sodium channel complexGO:0015189.6SCN4A, SCN7A
8integral component of plasma membraneGO:0058878.7RYR1, SLC12A3, CLCN1, SCN4A, KCNJ2
9plasma membraneGO:0058867.3RYR1, ABCC9, KCNJ12, KCNJ2, KCNJ18, CLCN1

Biological processes related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1potassium ion importGO:01010710.0KCNJ2, ABCC9
2membrane depolarization during cardiac muscle cell action potentialGO:0860129.9CACNA1D, KCNJ2
3skeletal muscle fiber developmentGO:0487419.9RYR1, CACNA1S
4calcium ion transportGO:0068169.8RYR1, CACNA1D, CACNA1S
5potassium ion transmembrane transportGO:0718059.7KCNJ18, KCNJ2, KCNJ12
6sodium ion transportGO:0068149.5SCN7A, SCN4A, SLC12A3
7regulation of heart rate by cardiac conductionGO:0860919.4KCNJ2, CACNA1D
8potassium ion transportGO:0068139.4ABCC9, KCNJ12, KCNJ2
9regulation of insulin secretionGO:0507969.3CACNA1C, CACNA1D, INS
10energy reserve metabolic processGO:0061129.3CACNA1C, CACNA1D, INS
11transmembrane transportGO:0550859.1RYR1, SLC12A3, CLCN1, ABCC9
12synaptic transmissionGO:0072689.0ABCC9, KCNJ12, KCNJ2, CACNA1C
13muscle contractionGO:0069368.5RYR1, KCNJ12, SCN7A, SCN4A, CLCN1, CACNA1S

Molecular functions related to Hypokalemic Periodic Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.8KCNE3, ABCC9
2alpha-actinin bindingGO:0513939.6CACNA1C, CACNA1D
3high voltage-gated calcium channel activityGO:0083319.6CACNA1C, CACNA1D, CACNA1S
4inward rectifier potassium channel activityGO:0052429.4KCNJ12, KCNJ2, KCNJ18
5voltage-gated calcium channel activityGO:0052459.4RYR1, CACNA1C, CACNA1D, CACNA1S
6voltage-gated sodium channel activityGO:0052489.3SCN4A, SCN7A

Products for genes affiliated with Hypokalemic Periodic Paralysis

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Sources for Hypokalemic Periodic Paralysis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet