MCID: HYP081
MIFTS: 49

Hypolipoproteinemia

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Hypolipoproteinemia

MalaCards integrated aliases for Hypolipoproteinemia:

Name: Hypolipoproteinemia 12 72 49 14
Lipoprotein Deficiencies 12 51
Lipoprotein Disorder 51 69
Hypolipoproteinaemia 12
Hypolipoproteinemias 41

Classifications:



External Ids:

Disease Ontology 12 DOID:1387
ICD10 32 E78.6
ICD9CM 34 272.5
MeSH 41 D007009

Summaries for Hypolipoproteinemia

NIH Rare Diseases : 49 Hypolipoproteinemia refers to unusually low levels of fats (lipids) in the blood. Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive thyroid, anemia, undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes abetalipoproteinemia, familial hypobetalipoproteinemia, and chylomicron retention disease. Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the low density lipoprotein (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual.  Last updated: 12/1/2016

MalaCards based summary : Hypolipoproteinemia, also known as lipoprotein deficiencies, is related to hypoalphalipoproteinemia, primary and tangier disease. An important gene associated with Hypolipoproteinemia is ABCA1 (ATP Binding Cassette Subfamily A Member 1), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Folic Acid and Niacin have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and endothelial, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Wikipedia : 72 Hypolipoproteinemia, hypolipidemia, or hypolipidaemia (British English) is a form of dyslipidemia that... more...

Related Diseases for Hypolipoproteinemia

Diseases related to Hypolipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 hypoalphalipoproteinemia, primary 31.6 ABCA1 APOA1 APOA2 APOB LCAT LPL
2 tangier disease 31.5 ABCA1 APOA1 APOA2 APOB APOE LCAT
3 fish-eye disease 30.4 APOA1 APOA2 LCAT
4 hypobetalipoproteinemia, familial, 1 29.7 ANGPTL3 APOA1 APOB APOE LCAT MTTP
5 lecithin:cholesterol acyltransferase deficiency 29.1 APOA1 APOA2 APOB APOE LCAT LPA
6 abetalipoproteinemia 28.8 ANGPTL3 APOA1 APOB APOE LCAT LPL
7 arteries, anomalies of 28.5 ABCA1 APOA1 APOB APOE LPA
8 coronary artery anomaly 27.5 ABCA1 APOA1 APOA2 APOB APOE LPA
9 body mass index quantitative trait locus 11 27.3 APOA1 APOA2 APOB APOE LPA LPL
10 wolman disease with hypolipoproteinemia and acanthocytosis 12.0
11 choreoacanthocytosis 10.7
12 xanthoma disseminatum 10.3 APOB APOE
13 hypercholesterolemia, autosomal dominant, type b 10.3 APOB APOE
14 hyperlipoproteinemia, type v 10.3 APOE LPL
15 sea-blue histiocyte disease 10.2 APOE LCAT
16 recurrent acute pancreatitis 10.2 APOE LPL
17 apo a-i deficiency 10.2 APOA1 LCAT
18 homozygous familial hypercholesterolemia 10.1 APOB APOE LPL
19 defective apolipoprotein b-100 10.1 APOB APOE LCAT
20 dysbaric osteonecrosis 10.1 APOA1 APOB
21 cerebral atherosclerosis 10.1 APOA1 APOE
22 aortic atherosclerosis 10.0 ABCA1 APOE LPA
23 vitamin e, familial isolated deficiency of 10.0 ABCA1 APOA1 APOB
24 hepatic lipase deficiency 10.0 APOA1 APOE LPL
25 fetal macrosomia 10.0 APOA1 APOB LCAT
26 coronary stenosis 9.9 APOA1 APOB APOE
27 brain injury 9.9
28 hepatitis 9.9
29 traumatic brain injury 9.9
30 gallbladder disease 9.9 APOA1 APOB APOE
31 schnyder corneal dystrophy 9.9 APOA2 APOB APOE
32 amyloidosis aa 9.9 APOA1 LCAT LPA
33 smith-lemli-opitz syndrome 9.9 ABCA1 APOE
34 macular degeneration, age-related, 1 9.9 ABCA1 APOB APOE
35 cerebrovascular disease 9.8 APOA1 APOB APOE
36 peripheral vascular disease 9.8 APOA1 APOB LPA
37 hereditary amyloidosis 9.8 APOA1 APOA2
38 xanthomatosis 9.8 APOB APOE LPA LPL
39 stroke, ischemic 9.8 APOB APOE LPA
40 ischemic heart disease 9.8 APOA1 APOB APOE LPL
41 hypertriglyceridemia, familial 9.8 APOA1 APOB APOE LPL
42 hyperlipidemia, familial combined 9.8 APOA1 APOB APOE LPL
43 amyloidosis, familial visceral 9.6 APOA1 APOA2 LPA
44 carotid artery disease 9.6 APOA1 APOB APOE LPA
45 hypertension, essential 9.6 APOA1 APOB LPA LPL
46 arteriosclerosis 9.6 APOA1 APOB APOE LPA
47 chylomicron retention disease 9.6 APOA1 APOB MTTP SAR1B
48 diabetes mellitus, insulin-dependent 9.5 APOA1 APOB LPA
49 body mass index quantitative trait locus 9 9.5
50 body mass index quantitative trait locus 8 9.5

Graphical network of the top 20 diseases related to Hypolipoproteinemia:



Diseases related to Hypolipoproteinemia

Symptoms & Phenotypes for Hypolipoproteinemia

GenomeRNAi Phenotypes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 APOB APOE LPA LPL ABCA1 APOA1
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LPL

MGI Mouse Phenotypes related to Hypolipoproteinemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ABCA1 APOA1 APOB APOE LCAT LPL
2 homeostasis/metabolism MP:0005376 9.65 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
3 liver/biliary system MP:0005370 9.23 APOA1 APOB APOE LCAT LPL MTTP

Drugs & Therapeutics for Hypolipoproteinemia

Drugs for Hypolipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
2
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
3
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
4 Antimetabolites Phase 4,Phase 2
5 Hypolipidemic Agents Phase 4,Phase 2
6 Lipid Regulating Agents Phase 4,Phase 2
7 Micronutrients Phase 4,Phase 3
8 Nicotinic Acids Phase 4
9 Trace Elements Phase 4,Phase 3
10 Vasodilator Agents Phase 4
11 Vitamin B Complex Phase 4
12 Vitamins Phase 4,Phase 3
13 Folate Nutraceutical Phase 4
14 Vitamin B3 Nutraceutical Phase 4
15 Vitamin B9 Nutraceutical Phase 4
16
Cosyntropin Approved Phase 3 16960-16-0 16129617
17
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
18
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 657311 5754
19 Racepinephrine Approved Phase 3 329-65-7
20 Tocopherol Approved, Investigational, Nutraceutical Phase 3
21
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
22 Antioxidants Phase 3
23 Protective Agents Phase 3
24 Tocopherols Phase 3
25 Tocotrienols Phase 3
26 Adrenergic Agents Phase 3
27 Adrenergic Agonists Phase 3
28 Adrenergic alpha-Agonists Phase 3
29 Adrenergic beta-Agonists Phase 3
30 Anti-Asthmatic Agents Phase 3
31 Autonomic Agents Phase 3
32 Bronchodilator Agents Phase 3
33 Cortisol succinate Phase 3
34 Epinephryl borate Phase 3
35 Hormone Antagonists Phase 3
36 Hormones Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
38 Hydrocortisone 17-butyrate 21-propionate Phase 3
39 Hydrocortisone acetate Phase 3
40 Mydriatics Phase 3
41 Neurotransmitter Agents Phase 3
42 Peripheral Nervous System Agents Phase 3
43 Respiratory System Agents Phase 3
44 Vasoconstrictor Agents Phase 3
45 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6
46
Mipomersen Approved, Investigational Phase 2 1000120-98-8
47 Anticholesteremic Agents Phase 2
48 Liver Extracts Phase 2
49
Fenofibrate Approved 49562-28-9 3339
50
Adenosine Approved, Investigational 58-61-7 60961

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL) Completed NCT00298909 Phase 4 niaspan (extended-release niacin);niacin
2 Short-term Effect of Extended-release Niacin on Endothelial Function. Completed NCT01942291 Phase 4 Niacin
3 Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention Completed NCT01457690 Phase 3 Tocofersolan;tocopherol alpha;Tocofersolan and tocopherol alpha
4 Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children Completed NCT01886495 Phase 3
5 Effect of High Protein Diet on Cardiovascular Diseases Risk Factors Among Overweight and Obese Children Completed NCT01886482 Phase 3
6 High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women Completed NCT01763528 Phase 3
7 CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases Recruiting NCT02697136 Phase 3 CER-001;Placebo
8 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
9 Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration Completed NCT00362180 Phase 2 mipomersen;Placebo
10 High-Density Lipoprotein (HDL) Treatment Study Completed NCT00458055 Atorvastatin; Fenofibrate; Niacin
11 Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia Completed NCT02889614
12 Tomato Consumption and High Density Lipoprotein-cholesterol Completed NCT01342666
13 Mechanisms of Low Levels of Apolipoprotein B Completed NCT00005565
14 Vitamin Replacement in Abetalipoproteinemia Completed NCT00004574
15 Quantitative Genetic Analysis of Lipid Research Clinic Family Data Completed NCT00005188
16 Evaluation of Lipoproteins Recruiting NCT00001168
17 HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism Recruiting NCT02354079
18 Inherited Retinal Degenerative Disease Registry Recruiting NCT02435940
19 Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins Recruiting NCT00001154
20 Mendelian Reverse Cholesterol Transport Study Suspended NCT01782027 3H-cholesterol bound to albumin

Search NIH Clinical Center for Hypolipoproteinemia

Cochrane evidence based reviews: hypolipoproteinemias

Genetic Tests for Hypolipoproteinemia

Anatomical Context for Hypolipoproteinemia

MalaCards organs/tissues related to Hypolipoproteinemia:

38
Liver, Thyroid, Endothelial, Brain

Publications for Hypolipoproteinemia

Articles related to Hypolipoproteinemia:

(show all 46)
# Title Authors Year
1
Significant association between hypolipoproteinemia(a) and lifetime risk of cancer: an autopsy study from a community-based Geriatric Hospital. ( 25164551 )
2014
2
A kindred with fish eye disease, corneal opacities, marked high-density lipoprotein deficiency, and statin therapy. ( 24636183 )
2014
3
Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cholesterol acyltransferase in non-Hodgkin lymphoma. ( 22271127 )
2012
4
Marked high density lipoprotein deficiency due to apolipoprotein A-I Tomioka (codon 138 deletion). ( 19473658 )
2009
5
Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients. ( 17993453 )
2007
6
Differential diagnosis of familial high density lipoprotein deficiency syndromes. ( 16343506 )
2006
7
Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. ( 16229851 )
2006
8
High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. ( 16087810 )
2005
9
Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). ( 15163665 )
2004
10
A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease. ( 14709355 )
2004
11
Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. ( 11785958 )
2002
12
Homogeneous assay based on 52 primer sets to scan for mutations of the ABCA1 gene and its application in genetic analysis of a new patient with familial high-density lipoprotein deficiency syndrome. ( 11476961 )
2001
13
Novel mutations in ABCA1 gene in Japanese patients with Tangier disease and familial high density lipoprotein deficiency with coronary heart disease. ( 11476965 )
2001
14
Cholesterol efflux from normal and Tangier disease fibroblasts into normal, high-density lipoprotein-deficient, and apolipoprotein E-deficient plasmas. ( 10877205 )
2000
15
High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. ( 10760292 )
2000
16
Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency. ( 10787172 )
2000
17
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. ( 10431236 )
1999
18
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. ( 8636092 )
1996
19
The pathology of cornea in Tangier disease (familial high density lipoprotein deficiency). ( 8707957 )
1996
20
The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages. ( 8645358 )
1996
21
Remodeling of HDL containing apoA-I but not apoA-II (LpA-I) by lipoprotein-deficient plasma and hepatic lipase: its effect on the structure and cellular cholesterol-reducing capacity of LpA-I. ( 8856043 )
1996
22
A nonsense mutation in the apolipoprotein A-I gene is associated with high-density lipoprotein deficiency and periorbital xanthelasmas. ( 7981179 )
1994
23
High density lipoprotein deficiency with xanthomas. A defect in reverse cholesterol transport caused by a point mutation in the apolipoprotein A-I gene. ( 7693760 )
1993
24
Determination of lipid transfer inhibitor protein activity in human lipoprotein-deficient plasma. ( 8241106 )
1993
25
Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling Tangier disease and their effects on intracellular cholesterol efflux. ( 8432861 )
1993
26
Elevated complement activities of sera from patients with high density lipoprotein deficiency (Tangier disease): the presence of normal level of clusterin and the possible implication in the atherosclerosis. ( 8348751 )
1993
27
Familial high-density-lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent. ( 1588268 )
1992
28
Acquired hypolipoproteinemia. ( 1582035 )
1992
29
A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities. ( 1898657 )
1991
30
Familial high-density lipoprotein deficiency (Tangier disease): the third Italian case. ( 3141697 )
1988
31
Apolipoprotein AI and AII metabolism in patients with primary high-density lipoprotein deficiency associated with familial hypertriglyceridemia. ( 3927110 )
1985
32
The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). ( 4063532 )
1985
33
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease). ( 6421598 )
1984
34
Tangier disease. High density lipoprotein deficiency due to defective metabolism of an abnormal apolipoprotein A-i (ApoA-ITangier). ( 7130397 )
1982
35
Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease). ( 7406376 )
1980
36
Ocular manifestations of familial high-density lipoprotein deficiency (Tangier disease). ( 226043 )
1979
37
Tangier disease (alpha-lipoprotein deficiency). ( 195100 )
1977
38
Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer. ( 163682 )
1975
39
Acrodermatitis enteropathica associated with low density lipoproteins deficiency. ( 4369743 )
1974
40
Hepatitis secondary to pyrazinamide toxicity: accompaniments of transient hypolipoproteinemia, acanthocytosis, and changes in stomach and small bowel. ( 5411920 )
1970
41
Acanthocytosis with beta-lipoprotein deficiency in an Indian girl. ( 5491083 )
1970
42
Wolman's disease with hypolipoproteinemia and acanthocytosis: clinical and biochemical observations. ( 5504079 )
1970
43
Neuropathy in Tangier disease. Alpha-Lipoprotein deficiency manifesting as familial recurrent neuropathy and intestinal lipid storage. ( 4165386 )
1967
44
Familial alpha-lipoprotein deficiency (Tangier disease) with neurological abnormalities. ( 4165172 )
1967
45
Tangier disease (familial high density lipoprotein deficiency). Clinical and genetic features in two adults. ( 5831900 )
1965
46
THE INHERITANCE OF HIGH DENSITY LIPOPROTEIN DEFICIENCY (TANGIER DISEASE). ( 14162531 )
1964

Variations for Hypolipoproteinemia

Expression for Hypolipoproteinemia

Search GEO for disease gene expression data for Hypolipoproteinemia.

Pathways for Hypolipoproteinemia

Pathways related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
2
Show member pathways
12.6 ABCA1 APOA1 APOA2 LPL
3
Show member pathways
12.41 APOA1 APOA2 APOB APOE LPL
4
Show member pathways
12.23 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
5
Show member pathways
12.07 ABCA1 APOA1 APOB APOE
6
Show member pathways
12.05 APOA1 APOA2 APOB APOE LPL
7
Show member pathways
11.67 APOA1 APOB APOE
8 11.49 APOA1 APOA2 LPL
9
Show member pathways
11.39 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
10
Show member pathways
11.1 ABCA1 APOA1 APOB MTTP
11 10.93 APOA1 APOA2
12 10.87 APOA1 APOB
13 10.82 ABCA1 APOA1 APOA2

GO Terms for Hypolipoproteinemia

Cellular components related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.95 ABCA1 ANGPTL3 APOE MTTP SAR1B
2 cell surface GO:0009986 9.84 ABCA1 ANGPTL3 APOA1 LPL
3 endoplasmic reticulum lumen GO:0005788 9.83 APOA1 APOA2 APOB APOE MTTP
4 early endosome GO:0005769 9.8 ANGPTL3 APOA1 APOA2 APOB APOE
5 blood microparticle GO:0072562 9.7 APOA1 APOA2 APOE
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 APOB APOE
7 high-density lipoprotein particle GO:0034364 9.55 ABCA1 APOA1 APOA2 APOE LCAT
8 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB APOE
9 spherical high-density lipoprotein particle GO:0034366 9.51 APOA1 APOA2
10 low-density lipoprotein particle GO:0034362 9.5 APOA1 APOB APOE
11 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
12 intermediate-density lipoprotein particle GO:0034363 9.43 APOA1 APOB APOE
13 very-low-density lipoprotein particle GO:0034361 9.35 APOA1 APOA2 APOB APOE LPL
14 chylomicron GO:0042627 9.02 APOA1 APOA2 APOB APOE LPL
15 extracellular region GO:0005576 10.08 ANGPTL3 APOA1 APOA2 APOB APOE LCAT
16 extracellular space GO:0005615 10.04 ANGPTL3 APOA1 APOA2 APOB APOE LCAT

Biological processes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.98 ABCA1 APOA1 APOB APOE LCAT
2 cellular protein metabolic process GO:0044267 9.97 APOA1 APOA2 APOB APOE
3 lipid transport GO:0006869 9.97 APOA1 APOA2 APOB APOE LPA MTTP
4 retinoid metabolic process GO:0001523 9.95 APOA1 APOA2 APOB APOE LPL
5 phospholipid metabolic process GO:0006644 9.93 ANGPTL3 APOA1 LCAT LPL
6 receptor-mediated endocytosis GO:0006898 9.9 APOA1 APOB APOE
7 triglyceride metabolic process GO:0006641 9.89 APOA2 APOE LPL MTTP
8 triglyceride homeostasis GO:0070328 9.88 ANGPTL3 APOA1 APOE LPL
9 cholesterol transport GO:0030301 9.88 ABCA1 APOA1 APOA2 APOB LCAT
10 regulation of lipid metabolic process GO:0019216 9.87 ABCA1 APOA1 APOA2
11 triglyceride catabolic process GO:0019433 9.87 APOA1 APOB APOE LPL
12 high-density lipoprotein particle remodeling GO:0034375 9.86 APOA1 APOA2 APOE LCAT
13 cholesterol efflux GO:0033344 9.85 ABCA1 APOA1 APOA2 APOB APOE
14 high-density lipoprotein particle assembly GO:0034380 9.84 ABCA1 APOA1 APOA2 APOE
15 phospholipid transport GO:0015914 9.83 ABCA1 APOA1 MTTP
16 low-density lipoprotein particle remodeling GO:0034374 9.83 APOA2 APOB APOE LPA
17 reverse cholesterol transport GO:0043691 9.83 ABCA1 APOA1 APOA2 APOE LCAT
18 phosphatidylcholine biosynthetic process GO:0006656 9.82 APOA1 APOA2 LCAT
19 artery morphogenesis GO:0048844 9.81 ANGPTL3 APOB APOE
20 phospholipid efflux GO:0033700 9.81 ABCA1 APOA1 APOA2 APOE
21 phospholipid homeostasis GO:0055091 9.8 ABCA1 ANGPTL3 APOA1
22 cholesterol metabolic process GO:0008203 9.8 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
23 positive regulation of cholesterol esterification GO:0010873 9.79 APOA1 APOA2 APOE
24 high-density lipoprotein particle clearance GO:0034384 9.79 APOA1 APOA2 APOE
25 regulation of Cdc42 protein signal transduction GO:0032489 9.78 ABCA1 APOA1 APOE
26 very-low-density lipoprotein particle remodeling GO:0034372 9.77 APOE LCAT LPL
27 chylomicron assembly GO:0034378 9.77 APOA1 APOA2 APOB APOE MTTP
28 animal organ regeneration GO:0031100 9.72 APOA1 APOA2
29 lipid homeostasis GO:0055088 9.72 ANGPTL3 APOE
30 lipid storage GO:0019915 9.72 ANGPTL3 APOA1
31 lipoprotein transport GO:0042953 9.72 APOB MTTP
32 chylomicron remodeling GO:0034371 9.72 APOA1 APOA2 APOB APOE LPL
33 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.71 APOB LPL
34 phospholipid catabolic process GO:0009395 9.71 ANGPTL3 APOA2
35 positive regulation of cholesterol efflux GO:0010875 9.71 ABCA1 APOE
36 protein lipidation GO:0006497 9.71 ABCA1 MTTP
37 very-low-density lipoprotein particle assembly GO:0034379 9.7 APOB MTTP
38 regulation of lipoprotein lipase activity GO:0051004 9.7 ANGPTL3 LPL
39 chylomicron remnant clearance GO:0034382 9.69 APOB APOE
40 neuron projection regeneration GO:0031102 9.69 APOA1 APOE
41 positive regulation of cholesterol storage GO:0010886 9.69 APOB LPL
42 positive regulation of lipid catabolic process GO:0050996 9.68 ANGPTL3 APOA2
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 APOA1 APOA2
44 peptidyl-methionine modification GO:0018206 9.68 APOA1 APOA2
45 very-low-density lipoprotein particle clearance GO:0034447 9.68 APOB APOE
46 regulation of intestinal cholesterol absorption GO:0030300 9.67 APOA1 APOA2
47 negative regulation of lipase activity GO:0060192 9.67 APOA1 APOA2
48 lipoprotein catabolic process GO:0042159 9.66 APOB APOE
49 protein oxidation GO:0018158 9.65 APOA1 APOA2
50 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.65 APOA1 APOA2

Molecular functions related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.85 APOA1 APOA2 APOB APOE MTTP
2 heparin binding GO:0008201 9.8 ANGPTL3 APOB APOE LPA LPL
3 cholesterol binding GO:0015485 9.67 ABCA1 APOA1 APOA2 APOE
4 phospholipid binding GO:0005543 9.65 ABCA1 APOA1 APOA2 APOB APOE
5 phospholipid transporter activity GO:0005548 9.61 ABCA1 APOA1 MTTP
6 phosphatidylcholine binding GO:0031210 9.57 APOA1 APOA2
7 low-density lipoprotein particle receptor binding GO:0050750 9.56 APOB APOE
8 high-density lipoprotein particle binding GO:0008035 9.55 APOA1 APOA2
9 lipase inhibitor activity GO:0055102 9.54 APOA1 APOA2
10 lipoprotein particle binding GO:0071813 9.52 APOA1 APOE
11 apolipoprotein A-I binding GO:0034186 9.51 ABCA1 LCAT
12 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.5 APOA1 APOA2 APOE
13 high-density lipoprotein particle receptor binding GO:0070653 9.49 APOA1 APOA2
14 apolipoprotein receptor binding GO:0034190 9.48 APOA1 APOA2
15 apolipoprotein binding GO:0034185 9.46 ABCA1 LPA LPL MTTP
16 lipid transporter activity GO:0005319 9.35 APOA1 APOA2 APOB APOE MTTP
17 cholesterol transporter activity GO:0017127 9.02 ABCA1 APOA1 APOA2 APOB APOE

Sources for Hypolipoproteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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