MCID: HYP024
MIFTS: 55

Hypoparathyroidism

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoparathyroidism

MalaCards integrated aliases for Hypoparathyroidism:

Name: Hypoparathyroidism 12 72 49 36 28 51 41 14 69
Hypoparathyroidism, Idiopathic 49
Parathyroid, Underactivity of 49

Classifications:



External Ids:

Disease Ontology 12 DOID:11199
ICD10 32 E20 E20.9 E20.0
ICD9CM 34 252.1
MeSH 41 D007011
NCIt 46 C78350
KEGG 36 H01862
UMLS 69 C0020626

Summaries for Hypoparathyroidism

NIH Rare Diseases : 49 Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body. Last updated: 3/10/2011

MalaCards based summary : Hypoparathyroidism, also known as hypoparathyroidism, idiopathic, is related to hypoparathyroidism, familial isolated and hypoparathyroidism-retardation-dysmorphism syndrome. An important gene associated with Hypoparathyroidism is GCM2 (Glial Cells Missing Homolog 2), and among its related pathways/superpathways are G alpha (s) signalling events and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Betamethasone and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and kidney, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Disease Ontology : 12 A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.

Wikipedia : 72 Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid... more...

Related Diseases for Hypoparathyroidism

Diseases in the Hypoparathyroidism family:

Secondary Hypoparathyroidism Due to Impaired Parathormon Secretion Autoimmune Hypoparathyroidism

Diseases related to Hypoparathyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 hypoparathyroidism, familial isolated 34.2 AIRE GCM2 PTH
2 hypoparathyroidism-retardation-dysmorphism syndrome 34.0 FAM111A PTH TBCE
3 hypocalcemia, autosomal dominant 1 33.5 CASR GCM2
4 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 33.1 AIRE CASR
5 autoimmune polyendocrine syndrome type 1 32.8 AIRE CASR
6 pseudohypoparathyroidism 31.1 BGLAP PTH PTH1R PTHLH
7 kenny-caffey syndrome 30.2 FAM111A TBCE
8 cohen-gibson syndrome 29.6 BGLAP FGF23
9 familial hypocalciuric hypercalcemia 29.4 CASR PTH SPG7
10 hyperphosphatemia 29.4 CASR FGF23 GCM2 PTH
11 hypercalcemia, infantile, 1 29.4 CASR PTH PTH1R PTHLH
12 hypophosphatemia 29.0 BGLAP FGF23 PTH
13 secondary hyperparathyroidism of renal origin 28.9 BGLAP CASR FGF23 PTH
14 pseudohypoparathyroidism, type ib 28.7 BGLAP PTH PTH1R PTHLH
15 osteomalacia 28.7 BGLAP CASR FGF23 PTHLH
16 hyperparathyroidism 28.6 BGLAP CASR FGF23 GCM2 PTH PTHLH
17 osteoporosis 26.6 ALPP BGLAP CASR FGF23 PTH PTH1R
18 primary hyperparathyroidism 26.6 ALPP BGLAP CASR FGF23 GCM2 PTH
19 hypoparathyroidism, sensorineural deafness, and renal disease 12.5
20 hypoparathyroidism-intellectual disability-dysmorphism syndrome 12.3
21 autoimmune hypoparathyroidism 12.1
22 secondary hypoparathyroidism due to impaired parathormon secretion 12.0
23 familial isolated hypoparathyroidism due to agenesis of parathyroid gland 12.0
24 lymphedema-hypoparathyroidism syndrome 11.9
25 hypoparathyroidism, x-linked 11.9
26 dahlberg borer newcomer syndrome 11.5
27 chromosome 10p deletion 11.3
28 pseudopseudohypoparathyroidism 11.2
29 pseudohypoparathyroidism, type ic 11.2
30 kenny-caffey syndrome, type 2 11.1
31 basal ganglia calcification, idiopathic, childhood-onset 10.8
32 velocardiofacial syndrome 10.8
33 kenny-caffey syndrome, type 1 10.8
34 ossification of the posterior longitudinal ligament of spine 10.8
35 primary hypomagnesemia 10.8
36 chief cell adenoma 10.5 GCM2 PTH
37 water-clear cell adenoma 10.5 GATA3 PTH
38 pseudopapilledema 10.4 GATA3 TBCE
39 sclerosing hepatic carcinoma 10.3 PTH PTHLH
40 hypocalciuric hypercalcemia, familial, type ii 10.3 CASR PTH
41 invasive malignant thymoma 10.3 PTH PTHLH
42 branchiootic syndrome 1 10.3
43 clear cell adenoma 10.3 PTH PTHLH
44 hypervitaminosis d 10.3 FGF23 PTH
45 jaw cancer 10.3 PTH PTHLH
46 renal dysplasia 10.2
47 hypocalciuric hypercalcemia, familial, type iii 10.2 CASR PTHLH
48 thyroiditis 10.2
49 axial osteomalacia 10.2 BGLAP PTH
50 pulmonary alveolar microlithiasis 10.2 FGF23 PTH

Comorbidity relations with Hypoparathyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hyperparathyroidism
Hypertension, Essential Hypothyroidism
Postsurgical Hypothyroidism

Graphical network of the top 20 diseases related to Hypoparathyroidism:



Diseases related to Hypoparathyroidism

Symptoms & Phenotypes for Hypoparathyroidism

MGI Mouse Phenotypes related to Hypoparathyroidism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 AIRE CASR FGF23 GATA3 GCM2 PTH
2 digestive/alimentary MP:0005381 9.73 AIRE CASR FGF23 GATA3 PTH1R PTHLH
3 mortality/aging MP:0010768 9.61 GATA3 GCM2 PTH PTH1R PTHLH TBCE
4 skeleton MP:0005390 9.23 CASR FGF23 GATA3 GCM2 PTH PTH1R

Drugs & Therapeutics for Hypoparathyroidism

Drugs for Hypoparathyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Calcium Carbonate Approved, Investigational Phase 4,Phase 1,Phase 2 471-34-1
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
5
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
6
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
8
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
9
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 10883523 5280795 6221
10 Anti-Asthmatic Agents Phase 4
11 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
12 Betamethasone acetate Phase 4
13 Betamethasone benzoate Phase 4
14 Betamethasone sodium phosphate Phase 4
15 Betamethasone Valerate Phase 4 2152-44-5
16 Betamethasone-17,21-dipropionate Phase 4
17 glucocorticoids Phase 4,Phase 1,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Respiratory System Agents Phase 4
22 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
24 Ergocalciferols Phase 4,Phase 3
25 Micronutrients Phase 4,Phase 3,Phase 2
26 Trace Elements Phase 4,Phase 3,Phase 2
27 Vitamins Phase 4,Phase 2,Phase 3
28 Antacids Phase 4,Phase 1,Phase 2
29 Anticoagulants Phase 4
30 Anti-Ulcer Agents Phase 4,Phase 1,Phase 2
31 Chelating Agents Phase 4
32 Gastrointestinal Agents Phase 4,Phase 1,Phase 2
33 Antipsychotic Agents Phase 4
34 Central Nervous System Depressants Phase 4
35 Central Nervous System Stimulants Phase 4
36 Dopamine Agents Phase 4
37 Dopamine Antagonists Phase 4
38 Dopamine Uptake Inhibitors Phase 4
39 Neurotransmitter Agents Phase 4
40 Neurotransmitter Uptake Inhibitors Phase 4
41 Psychotropic Drugs Phase 4
42
Serotonin Phase 4 50-67-9 5202
43 Serotonin Agents Phase 4
44 Serotonin Antagonists Phase 4
45 Tranquilizing Agents Phase 4
46 Calciferol Nutraceutical Phase 4,Phase 3
47 Vitamin D2 Nutraceutical Phase 4,Phase 3
48 Calcium Supplement Nutraceutical Phase 4,Phase 1,Phase 2
49 Citrate Nutraceutical Phase 4
50
Teriparatide Approved, Investigational Phase 2, Phase 3 52232-67-4 16133850

Interventional clinical trials:

(show top 50) (show all 97)

# Name Status NCT ID Phase Drugs
1 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
2 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4 Vitamin D
3 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4 methylphenidate, fluoxetin, risperidone
4 Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism Active, not recruiting NCT02910466 Phase 4 rhPTH(1-84)
5 Vitamin D Deficiency and Postoperative Hypocalcemia Active, not recruiting NCT01632514 Phase 4 Cholecalciferol
6 Study of the Effect of Recombinant Human Parathyroid Hormone [rhPTH(1-84)] on Metabolic Control and Symptoms Among Adults With Hypoparathyroidism Not yet recruiting NCT03324880 Phase 4
7 Efficacy of Calcium Citrate Versus Calcium Carbonate in Maintaining Normal Serum Calcium Level and Changing Quality of Life in Patients With Chronic Hypoparathyroidism Not yet recruiting NCT03425747 Phase 4 Calcium Carbonate;Calcium Citrate
8 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
9 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
10 Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY) Completed NCT01268098 Phase 3 NPSP558
11 Use of NPSP558 in the Treatment of Hypoparathyroidism Completed NCT00732615 Phase 3 Placebo;NPSP558
12 A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary Completed NCT01455181 Phase 3 NPSP558
13 Bone Properties in Hypoparathyroidism: Effects of PTH Completed NCT00473265 Phase 2, Phase 3 PTH
14 Effects of PTH Replacement on Bone in Hypoparathyroidism Completed NCT00395538 Phase 3 PTH 1-34
15 A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE) Active, not recruiting NCT01297309 Phase 3 NPSP558
16 ADD-ON Study to Existing Hypoparathyroidism Studies Active, not recruiting NCT00856401 Phase 3 PTH1-84 in parent study
17 HEXT (Hypo EXTended): Effect of PTH on Skeleton in Hypoparathyroidism Active, not recruiting NCT01199614 Phase 3 open-label PTH(1-84)
18 Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer Active, not recruiting NCT01608451 Phase 3 Cholecalciferol;Inj. Progesterone
19 Safety and Efficacy Study of rhPTH(1-84) in Subjects With Hypoparathyroidism Not yet recruiting NCT03364738 Phase 3
20 Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life Completed NCT00730210 Phase 2 a: PTH (1-84);b:placebo
21 A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients Completed NCT01815021 Phase 1, Phase 2
22 A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism Completed NCT02152228 Phase 2 EnteraBio's Oral Parathyroid Hormone (1-34)
23 Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34 Completed NCT00001304 Phase 2 Synthetic Human Parathyroid Hormone 1-34;Calcitriol & Calcium
24 Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery Completed NCT02089542 Phase 1, Phase 2
25 A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations Completed NCT02204579 Phase 2 NPSP795
26 Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism Recruiting NCT02824718 Phase 2 Teriparatide;Thiazide;Potassium sparing diuretic;Alfacalcidol
27 Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer Recruiting NCT02138214 Phase 2
28 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2 Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
29 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Daclizumab;Mycophenolate mofetil
30 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
31 Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer Active, not recruiting NCT02408887 Phase 2
32 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
33 Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2 Teriparatide
34 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
35 Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects Completed NCT03150108 Phase 1 rhPTH(1-84);rhPTH(1-84);rhPTH(1-84)
36 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1 NFC-1
37 Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Subjects With Hypoparathyroidism Recruiting NCT02781844 Phase 1 25mcg rhPTH(1-84);50mcg rhPTH(1-84);100mcg rhPTH(1-84);rhpth(1-84)
38 EIS in Thyroid and Parathyroid Surgery Recruiting NCT02901873 Phase 1
39 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
40 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
41 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
42 Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy Unknown status NCT01039714
43 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955
44 Genetics and Psychopathology in the 22q11 Deletion Syndrome Unknown status NCT00161109
45 Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome Unknown status NCT00005102
46 Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy Completed NCT02924532
47 Hypoparathyroidism in Denmark Completed NCT01498341
48 Burden of Illness in Hypoparathyroidism Completed NCT03437174
49 Magnesium Treatment in Hypoparathyroidism Completed NCT00824226
50 Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism Completed NCT00743782 Early Phase 1 Synthetic Human Parathyroid Hormone 1-34

Search NIH Clinical Center for Hypoparathyroidism

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypoparathyroidism

Genetic Tests for Hypoparathyroidism

Genetic tests related to Hypoparathyroidism:

# Genetic test Affiliating Genes
1 Hypoparathyroidism 28

Anatomical Context for Hypoparathyroidism

MalaCards organs/tissues related to Hypoparathyroidism:

38
Thyroid, Testes, Kidney, Bone, Thymus, Skin, Lymph Node

Publications for Hypoparathyroidism

Articles related to Hypoparathyroidism:

(show top 50) (show all 768)
# Title Authors Year
1
Does the number of parathyroid glands autotransplanted affect the incidence of hypoparathyroidism and recovery of parathyroid function? ( 29398031 )
2018
2
Primary hypoparathyroidism presenting as basal ganglia calcification secondary to extreme hypocalcemia. ( 29383229 )
2018
3
Isolated ligamentum flavum ossification in primary hypoparathyroidism. ( 29399376 )
2018
4
MILK-ALKALI SYNDROME (MAS) as a complication of the treatment of hypoparathyroidism. ( 29442351 )
2018
5
Intracranial Calcification Due to Hypoparathyroidism. ( 29355508 )
2018
6
The hypoparathyroidism-deafness-renal dysplasia syndrome: A case report. ( 29398643 )
2018
7
An ICET- A survey on Hypoparathyroidism in Patients with Thalassaemia Major and Intermedia: A preliminary report. ( 29350657 )
2018
8
Effect of autotransplantation of a parathyroid gland on hypoparathyroidism after total thyroidectomy. ( 29301864 )
2018
9
Quality of life in hypoparathyroidism. ( 29181618 )
2018
10
Hypoparathyroidism. ( 28857066 )
2017
11
Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. ( 28822059 )
2017
12
Long-Term Complications in Patients With Hypoparathyroidism Evaluated by Biochemical Findings: A Case-Control Study. ( 29281760 )
2017
13
Hypoparathyroidism Should Always Be Checked in Papilledema. ( 28694607 )
2017
14
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. ( 28051179 )
2017
15
Repurposing a novel parathyroid hormone (PTH) analog to treat hypoparathyroidism. ( 28898923 )
2017
16
Peripheral Neuropathy, Episodic Rhabdomyolysis, and Hypoparathyroidism in a Patient with Mitochondrial Trifunctional Protein Deficiency. ( 28685493 )
2017
17
Hypoparathyroidism: what is the best calcium carbonate supplementation intake form? ( 29279189 )
2017
18
A Case of "Late" Postsurgical Hypoparathyroidism. ( 28642829 )
2017
19
Pandora's Box: Neurological Manifestations of Hypoparathyroidism. ( 28670554 )
2017
20
Short stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene. ( 28138333 )
2017
21
Teaching NeuroImages: Fahr syndrome caused by hypoparathyroidism. ( 28583940 )
2017
22
Generalized pustular psoriasis: A possible association with severe hypocalcaemia due to primary hypoparathyroidism. ( 28106254 )
2017
23
Postoperative hypoparathyroidism in patients after total thyroidectomy - retrospective analysis. ( 29369600 )
2017
24
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
25
POSTOPERATIVE TRANSIENT HYPOPARATHYROIDISM: INCIDENCE AND RISK FACTORS - A SOUTH AFRICAN PERSPECTIVE. ( 28876588 )
2017
26
Hypoparathyroidism ( 28722928 )
2017
27
A Novel De novo GATA-binding Protein 3 Mutation in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome. ( 28524840 )
2017
28
Continuous Subcutaneous Recombinant Parathyroid Hormone (1-34) Infusion in the Management of Childhood Hypoparathyroidism Associated with Malabsorption. ( 28926829 )
2017
29
Nutritional Nightmare: Hypoparathyroidism Secondary to Celiac Disease. ( 28826689 )
2017
30
Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism. ( 28323927 )
2017
31
Safety and Efficacy of Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism Randomly Assigned to Receive Fixed 25-I1g or 50-I1g Daily Doses. ( 28942334 )
2017
32
Clinical Auditory Phenotypes Associated with GATA3 Gene Mutations in Familial Hypoparathyroidism-deafness-renal Dysplasia Syndrome. ( 28303854 )
2017
33
Incidence, prevalence and risk factors for post-surgical hypocalcaemia and hypoparathyroidism. ( 29322023 )
2017
34
Recurrent laryngeal nerve injury and hypoparathyroidism rates in reoperative thyroid surgery. ( 28589182 )
2017
35
Letter to the Editor: "Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol". ( 28911157 )
2017
36
A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. ( 28444561 )
2017
37
Post-thyroidectomy hypoparathyroidism, what should we keep in mind? ( 29197191 )
2017
38
Hypocalcaemia and permanent hypoparathyroidism after total/bilateral thyroidectomy in the BAETS Registry. ( 29322024 )
2017
39
Response to Letter: "Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol". ( 28911162 )
2017
40
A nomogram to predict the likelihood of permanent hypoparathyroidism after total thyroidectomy based on delayed serum calcium and iPTH measurements. ( 29322018 )
2017
41
Clinical profile and long-term follow-up of 32 patients with postoperative permanent hypoparathyroidism. ( 29322017 )
2017
42
Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection. ( 28953664 )
2017
43
Hypoparathyroidism. ( 28857067 )
2017
44
Bone Status Among Patients With Nonsurgical Hypoparathyroidism, Autosomal Dominant Hypocalcaemia, and Pseudohypoparathyroidism: A Cohort Study. ( 29087612 )
2017
45
Failure of fragmented parathyroid gland autotransplantation to prevent permanent hypoparathyroidism after total thyroidectomy. ( 28064342 )
2017
46
The PGRIS and parathyroid splinting concepts for the analysis and prognosis of protracted hypoparathyroidism. ( 29322026 )
2017
47
Hypoparathyroidism, Deafness & Renal Dysplasia (HDR) Syndrome & GATA3. ( 29025137 )
2017
48
The dental manifestations and orthodontic implications of hypoparathyroidism in childhood. ( 29191124 )
2017
49
Novel Autosomal Dominant PTH Gene Signal Sequence Mutation in a Family with Familial Isolated Hypoparathyroidism. ( 28938448 )
2017
50
Risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy: a retrospective Chinese population study. ( 29180898 )
2017

Variations for Hypoparathyroidism

Expression for Hypoparathyroidism

Search GEO for disease gene expression data for Hypoparathyroidism.

Pathways for Hypoparathyroidism

GO Terms for Hypoparathyroidism

Biological processes related to Hypoparathyroidism according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.69 BGLAP GATA3 PTH
2 ossification GO:0001503 9.67 BGLAP CASR PTH1R
3 cell maturation GO:0048469 9.58 GATA3 PTH1R
4 bone mineralization GO:0030282 9.58 BGLAP PTH1R
5 developmental growth GO:0048589 9.57 GATA3 TBCE
6 bone resorption GO:0045453 9.56 PTH PTH1R
7 skeletal system development GO:0001501 9.56 BGLAP PTH PTH1R PTHLH
8 regulation of bone mineralization GO:0030500 9.55 BGLAP FGF23
9 response to vitamin D GO:0033280 9.54 BGLAP PTH
10 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.54 PTH PTH1R PTHLH
11 negative regulation of chondrocyte differentiation GO:0032331 9.52 PTH PTHLH
12 cellular phosphate ion homeostasis GO:0030643 9.48 FGF23 GCM2
13 positive regulation of inositol phosphate biosynthetic process GO:0060732 9.46 PTH PTH1R
14 cellular calcium ion homeostasis GO:0006874 9.46 CASR GCM2 PTH PTH1R
15 parathyroid gland development GO:0060017 9.43 GATA3 GCM2
16 response to fibroblast growth factor GO:0071774 9.4 CASR PTH
17 cAMP metabolic process GO:0046058 9.32 PTH PTHLH
18 osteoblast development GO:0002076 9.13 BGLAP PTH1R PTHLH
19 cellular response to vitamin D GO:0071305 8.8 BGLAP CASR FGF23

Molecular functions related to Hypoparathyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Hypoparathyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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