MCID: HYP024
MIFTS: 52

Hypoparathyroidism

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoparathyroidism

MalaCards integrated aliases for Hypoparathyroidism:

Name: Hypoparathyroidism 12 50 29 52 42 14 69
Hypoparathyroidism, Idiopathic 50
Parathyroid, Underactivity of 50

Classifications:



External Ids:

Disease Ontology 12 DOID:11199
ICD10 33 E20 E20.9 E20.0
ICD9CM 35 252.1
MeSH 42 D007011
NCIt 47 C78350
UMLS 69 C0020626

Summaries for Hypoparathyroidism

NIH Rare Diseases : 50 hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (pth). common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). it may be caused by injury to the parathyroid glands (e.g., during surgery). other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, digeorge syndrome, and type i polyglandular autoimmune syndrome. the goal of treatment is to restore the calcium and mineral balance in the body. last updated: 3/10/2011

MalaCards based summary : Hypoparathyroidism, also known as hypoparathyroidism, idiopathic, is related to hypoparathyroidism-retardation-dysmorphism syndrome and ossification of the posterior longitudinal ligament of spine. An important gene associated with Hypoparathyroidism is PTH (Parathyroid Hormone), and among its related pathways/superpathways are G alpha (s) signalling events and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Betamethasone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and kidney, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Disease Ontology : 12 A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.

Wikipedia : 72 Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid... more...

Related Diseases for Hypoparathyroidism

Diseases in the Hypoparathyroidism family:

Secondary Hypoparathyroidism Due to Impaired Parathormon Secretion Autoimmune Hypoparathyroidism

Diseases related to Hypoparathyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
id Related Disease Score Top Affiliating Genes
1 hypoparathyroidism-retardation-dysmorphism syndrome 34.2 FAM111A PTH TBCE
2 ossification of the posterior longitudinal ligament of spine 31.8 GATA3 GCM2 PTH
3 protein-losing enteropathy 29.2 BGLAP FGF23 PTH
4 hypoparathyroidism, familial isolated 12.3
5 hypoparathyroidism, sensorineural deafness, and renal dysplasia 12.2
6 hypoparathyroidism-deafness-renal disease syndrome 12.1
7 hypoparathyroidism-intellectual disability-dysmorphism syndrome 12.0
8 autoimmune hypoparathyroidism 11.9
9 secondary hypoparathyroidism due to impaired parathormon secretion 11.8
10 familial isolated hypoparathyroidism due to agenesis of parathyroid gland 11.8
11 hypoparathyroidism, x-linked 11.8
12 lymphedema-hypoparathyroidism syndrome 11.7
13 hypocalcemia, autosomal dominant 11.7
14 hypoparathyroidism short stature mental retardation 11.7
15 casr-associated familial isolated hypoparathyroidism 11.7
16 casr-related familial isolated hypoparathyroidism 11.7
17 gcm2-related familial isolated hypoparathyroidism 11.7
18 pth-related familial isolated hypoparathyroidism 11.7
19 autoimmune polyendocrine syndrome type 1 11.6
20 autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia 11.5
21 dahlberg borer newcomer syndrome 11.4
22 pseudohypoparathyroidism 11.4
23 chromosome 10p deletion 11.2
24 kearns-sayre syndrome 11.1
25 pseudohypoparathyroidism ic 11.1
26 pseudopseudohypoparathyroidism 11.0
27 kenny-caffey syndrome, type 2 11.0
28 velocardiofacial syndrome 10.7
29 primary hypomagnesemia 10.7
30 kenny-caffey syndrome, type 1 10.7
31 pulmonary neuroendocrine tumor 10.7 GATA3 PTH
32 epidermolysis bullosa simplex with anodontia/hypodontia 10.6 FAM111A TBCE
33 lacrimal duct obstruction 10.6 GATA3 TBCE
34 pineal gland cancer 10.5 PTH PTHLH
35 hypocalcemia, autosomal dominant 2 10.5 CASR PTH
36 teratocarcinoma 10.5 PTH PTHLH
37 epilepsy idiopathic generalized 8 10.5 CASR GCM2
38 brain angioma 10.5 PTH PTHLH
39 drug dependence 10.4 FGF23 PTH
40 impotence 10.4 PTH PTHLH
41 hyperparathyroidism 4 10.4 AIRE GCM2 PTH
42 cerebrooculofacioskeletal syndrome 4 10.4 CASR PTHLH
43 achondrogenesis 10.4 BGLAP PTH
44 white sponge nevus of cannon, krt4-related 10.4 BGLAP PTH
45 joubert syndrome 9 10.3 FGF23 PTH
46 mixed cell type adenoma of parathyroid 10.3 BGLAP PTH
47 histiocytoid hemangioma 10.3 CASR FGF23
48 coffin-lowry syndrome 10.3 FGF23 PTH
49 anal canal squamous cell carcinoma 10.3 PTH PTHLH
50 methylmalonic acidemia due to transcobalamin receptor defect 10.3 CASR PTH SPG7

Comorbidity relations with Hypoparathyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hyperparathyroidism
Hypertension, Essential Hypothyroidism
Postsurgical Hypothyroidism

Graphical network of the top 20 diseases related to Hypoparathyroidism:



Diseases related to Hypoparathyroidism

Symptoms & Phenotypes for Hypoparathyroidism

MGI Mouse Phenotypes related to Hypoparathyroidism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.73 AIRE CASR FGF23 GATA3 PTH1R PTHLH
2 endocrine/exocrine gland MP:0005379 9.7 AIRE CASR FGF23 GATA3 GCM2 PTH
3 mortality/aging MP:0010768 9.61 CASR FGF23 GATA3 GCM2 PTH PTH1R
4 skeleton MP:0005390 9.23 CASR FGF23 GATA3 GCM2 PTH PTH1R

Drugs & Therapeutics for Hypoparathyroidism

Drugs for Hypoparathyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
6
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
7
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
8 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
9 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Ergocalciferols Phase 4,Phase 3
11 Micronutrients Phase 4,Phase 3,Phase 2
12 Trace Elements Phase 4,Phase 3,Phase 2
13 Vitamins Phase 4,Phase 2,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
15 glucocorticoids Phase 4,Phase 1,Phase 2
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Anti-Asthmatic Agents Phase 4
20 Betamethasone acetate Phase 4
21 Betamethasone benzoate Phase 4
22 Betamethasone sodium phosphate Phase 4
23 Betamethasone Valerate Phase 4 2152-44-5
24 Betamethasone-17,21-dipropionate Phase 4
25 Respiratory System Agents Phase 4
26 Antipsychotic Agents Phase 4
27 Central Nervous System Depressants Phase 4
28 Central Nervous System Stimulants Phase 4
29 Dopamine Agents Phase 4
30 Dopamine Antagonists Phase 4
31 Dopamine Uptake Inhibitors Phase 4
32 Neurotransmitter Agents Phase 4
33 Neurotransmitter Uptake Inhibitors Phase 4
34 Psychotropic Drugs Phase 4
35
Serotonin Phase 4 50-67-9 5202
36 Serotonin Agents Phase 4
37 Serotonin Antagonists Phase 4
38 Tranquilizing Agents Phase 4
39 Calciferol Nutraceutical Phase 4,Phase 3
40 Vitamin D2 Nutraceutical Phase 4,Phase 3
41
Teriparatide Approved, Investigational Phase 2, Phase 3 52232-67-4 16133850
42
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
43 Tocopherol Approved, Nutraceutical Phase 2, Phase 3
44
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-02-9 14985
45 Coagulants Phase 3
46 Hemostatics Phase 3
47 Tocopherols Phase 2, Phase 3
48 Tocotrienols Phase 2, Phase 3
49 11-hydroxyprogesterone Phase 3
50 17-alpha-hydroxy-progesterone caproate Phase 3

Interventional clinical trials:

(show top 50) (show all 91)

id Name Status NCT ID Phase Drugs
1 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4 Vitamin D
2 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Recruiting NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
3 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4 methylphenidate, fluoxetin, risperidone
4 Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism Active, not recruiting NCT02910466 Phase 4 rhPTH(1-84)
5 Vitamin D Deficiency and Postoperative Hypocalcemia Active, not recruiting NCT01632514 Phase 4 Cholecalciferol
6 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
7 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
8 Use of NPSP558 in the Treatment of Hypoparathyroidism Completed NCT00732615 Phase 3 Placebo;NPSP558
9 Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY) Completed NCT01268098 Phase 3 NPSP558
10 A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary Completed NCT01455181 Phase 3 NPSP558
11 Bone Properties in Hypoparathyroidism: Effects of PTH Completed NCT00473265 Phase 2, Phase 3 PTH
12 ADD-ON Study to Existing Hypoparathyroidism Studies Completed NCT00856401 Phase 3 PTH1-84 in parent study
13 Effects of PTH Replacement on Bone in Hypoparathyroidism Completed NCT00395538 Phase 3 PTH 1-34
14 A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE) Active, not recruiting NCT01297309 Phase 3 NPSP558
15 HEXT (Hypo EXTended): Effect of PTH on Skeleton in Hypoparathyroidism Active, not recruiting NCT01199614 Phase 3 open-label PTH(1-84)
16 Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer Active, not recruiting NCT01608451 Phase 3 Cholecalciferol;Inj. Progesterone
17 Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life Completed NCT00730210 Phase 2 a: PTH (1-84);b:placebo
18 Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34 Completed NCT00001304 Phase 2 Synthetic Human Parathyroid Hormone 1-34;Calcitriol & Calcium
19 A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients Completed NCT01815021 Phase 1, Phase 2
20 A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism Completed NCT02152228 Phase 2 EnteraBio's Oral Parathyroid Hormone (1-34)
21 Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery Completed NCT02089542 Phase 1, Phase 2
22 A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations Completed NCT02204579 Phase 2 NPSP795
23 Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism Recruiting NCT02824718 Phase 2 Teriparatide;Thiazide;Potassium sparing diuretic;Alfacalcidol
24 Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer Recruiting NCT02138214 Phase 2
25 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2 Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
26 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Daclizumab;Mycophenolate mofetil
27 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
28 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
29 Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2 Teriparatide
30 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
31 Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects Completed NCT03150108 Phase 1 rhPTH(1-84);rhPTH(1-84);rhPTH(1-84)
32 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1 NFC-1
33 Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Subjects With Hypoparathyroidism Recruiting NCT02781844 Phase 1 25mcg rhPTH(1-84);50mcg rhPTH(1-84);100mcg rhPTH(1-84);rhpth(1-84)
34 EIS in Thyroid and Parathyroid Surgery Recruiting NCT02901873 Phase 1
35 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
36 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
37 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
38 Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy Unknown status NCT01039714
39 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955
40 Genetics and Psychopathology in the 22q11 Deletion Syndrome Unknown status NCT00161109
41 Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome Unknown status NCT00005102
42 Hypoparathyroidism in Denmark Completed NCT01498341
43 Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy Completed NCT02924532
44 Magnesium Treatment in Hypoparathyroidism Completed NCT00824226
45 Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism Completed NCT00743782 Early Phase 1 Synthetic Human Parathyroid Hormone 1-34
46 Perioperative Parathormone Measurement and Sodium Bicarbonate Infusion Test After Total Thyroidectomy Completed NCT00793689
47 Physiologic Regulation of FGF-23 Completed NCT00356512
48 Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects Completed NCT00004361 calcium gluconate;sodium citrate
49 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
50 Determinants of Thyroid Surgery Outcomes Completed NCT02813733

Search NIH Clinical Center for Hypoparathyroidism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypoparathyroidism

Genetic Tests for Hypoparathyroidism

Genetic tests related to Hypoparathyroidism:

id Genetic test Affiliating Genes
1 Hypoparathyroidism 29

Anatomical Context for Hypoparathyroidism

MalaCards organs/tissues related to Hypoparathyroidism:

39
Thyroid, Testes, Kidney, Bone, Thymus, Skin, Lymph Node

Publications for Hypoparathyroidism

Articles related to Hypoparathyroidism:

(show top 50) (show all 745)
id Title Authors Year
1
Pandora's Box: Neurological Manifestations of Hypoparathyroidism. ( 28670554 )
2017
2
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. ( 28051179 )
2017
3
Short stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene. ( 28138333 )
2017
4
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
5
Letter to the Editor: "Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol". ( 28911157 )
2017
6
Generalized pustular psoriasis: A possible association with severe hypocalcaemia due to primary hypoparathyroidism. ( 28106254 )
2017
7
Clinical Auditory Phenotypes Associated with GATA3 Gene Mutations in Familial Hypoparathyroidism-deafness-renal Dysplasia Syndrome. ( 28303854 )
2017
8
POSTOPERATIVE TRANSIENT HYPOPARATHYROIDISM: INCIDENCE AND RISK FACTORS - A SOUTH AFRICAN PERSPECTIVE. ( 28876588 )
2017
9
Repurposing a novel parathyroid hormone (PTH) analog to treat hypoparathyroidism. ( 28898923 )
2017
10
Hypoparathyroidism. ( 28857067 )
2017
11
A Case of "Late" Postsurgical Hypoparathyroidism. ( 28642829 )
2017
12
Failure of fragmented parathyroid gland autotransplantation to prevent permanent hypoparathyroidism after total thyroidectomy. ( 28064342 )
2017
13
Safety and Efficacy of Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism Randomly Assigned to Receive Fixed 25-I1g or 50-I1g Daily Doses. ( 28942334 )
2017
14
Novel Autosomal Dominant PTH Gene Signal Sequence Mutation in a Family with Familial Isolated Hypoparathyroidism. ( 28938448 )
2017
15
Continuous Subcutaneous Recombinant Parathyroid Hormone (1-34) Infusion in the Management of Childhood Hypoparathyroidism Associated with Malabsorption. ( 28926829 )
2017
16
Nutritional Nightmare: Hypoparathyroidism Secondary to Celiac Disease. ( 28826689 )
2017
17
Hypoparathyroidism ( 28722928 )
2017
18
Response to Letter: "Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol". ( 28911162 )
2017
19
Hypoparathyroidism Should Always Be Checked in Papilledema. ( 28694607 )
2017
20
Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection. ( 28953664 )
2017
21
Recurrent laryngeal nerve injury and hypoparathyroidism rates in reoperative thyroid surgery. ( 28589182 )
2017
22
A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. ( 28444561 )
2017
23
Hypoparathyroidism. ( 28857066 )
2017
24
Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. ( 28822059 )
2017
25
Afebrile Seizures as Initial Symptom of Hypocalcemia Secondary to Hypoparathyroidism. ( 28694646 )
2017
26
Peripheral Neuropathy, Episodic Rhabdomyolysis, and Hypoparathyroidism in a Patient with Mitochondrial Trifunctional Protein Deficiency. ( 28685493 )
2017
27
Teaching NeuroImages: Fahr syndrome caused by hypoparathyroidism. ( 28583940 )
2017
28
A Novel De novo GATA-binding Protein 3 Mutation in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome. ( 28524840 )
2017
29
Clinical and mutational spectrum of hypoparathyroidism, deafness and renal dysplasia syndrome. ( 27387476 )
2016
30
The deceptive concept of hypoparathyroidism and recurrence after parathyroidectomy in dialysis patients: are we offering a Procrustean bed to some patients? ( 27982325 )
2016
31
Vertebral fractures and bone mineral density in patients with idiopathic hypoparathyroidism on long term follow-up. ( 27813708 )
2016
32
Extensive bilateral striopallidodentate calcinosis: a 50A years history of hypoparathyroidism presenting like a parkinsonian syndrome. ( 27485169 )
2016
33
Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism. ( 27942265 )
2016
34
Hypoparathyroidism after total thyroidectomy: prospective evaluation and relation with early hypocalcemia. ( 27346692 )
2016
35
Fahr's Syndrome and Secondary Hypoparathyroidism. ( 27141572 )
2016
36
Computed tomography anomalies associated with isolated hypoparathyroidism. ( 27980765 )
2016
37
Treatment of severe life threatening hypocalcemia with recombinant human teriparatide in patients with postoperative hypoparathyroidism - a case series. ( 27387245 )
2016
38
Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2. ( 27803672 )
2016
39
Epidemiology and Diagnosis of Hypoparathyroidism. ( 26943720 )
2016
40
The risk of hypoparathyroidism after central compartment lymph node dissection in the surgical treatment of pT1, N0 thyroid papillary carcinoma. ( 27212170 )
2016
41
Serum 1,25-dihydroxyvitamin D as a biomarker of the absence of hypercalciuria in postsurgical hypoparathyroidism. ( 27813709 )
2016
42
Presentation of Hypoparathyroidism: Etiologies and Clinical Features. ( 26943721 )
2016
43
Presence of Auto-reactive, MHC class-I restricted, Calcium Sensing Receptor (CaSR) specific CD8(+) T cells in Idiopathic Hypoparathyroidism. ( 27805845 )
2016
44
A case of brain calcifications in postsurgical hypoparathyroidism. ( 26968176 )
2016
45
Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. ( 27857062 )
2016
46
Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require antiepileptic drugs. ( 27957632 )
2016
47
Coexistence of cutaneous phosphaturic mesenchymal tumour and postoperative hypoparathyroidism. ( 27032881 )
2016
48
Early onset brain calcifications secondary to hypoparathyroidism in a boy with syncopal-like symptomatology. ( 27909973 )
2016
49
Predictors and risk factors of hypoparathyroidism after total thyroidectomy. ( 27554178 )
2016
50
Postoperative Hypoparathyroidism and the Viability of the Parathyroid Glands During Thyroidectomy. ( 27515510 )
2016

Variations for Hypoparathyroidism

Expression for Hypoparathyroidism

Search GEO for disease gene expression data for Hypoparathyroidism.

Pathways for Hypoparathyroidism

GO Terms for Hypoparathyroidism

Biological processes related to Hypoparathyroidism according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.69 BGLAP GATA3 PTH
2 ossification GO:0001503 9.67 BGLAP CASR PTH1R
3 cell maturation GO:0048469 9.58 GATA3 PTH1R
4 bone mineralization GO:0030282 9.58 BGLAP PTH1R
5 developmental growth GO:0048589 9.57 GATA3 TBCE
6 bone resorption GO:0045453 9.56 PTH PTH1R
7 skeletal system development GO:0001501 9.56 BGLAP PTH PTH1R PTHLH
8 response to vitamin D GO:0033280 9.55 BGLAP PTH
9 regulation of bone mineralization GO:0030500 9.54 BGLAP FGF23
10 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.54 PTH PTH1R PTHLH
11 negative regulation of chondrocyte differentiation GO:0032331 9.52 PTH PTHLH
12 cellular phosphate ion homeostasis GO:0030643 9.48 FGF23 GCM2
13 positive regulation of inositol phosphate biosynthetic process GO:0060732 9.46 PTH PTH1R
14 cellular calcium ion homeostasis GO:0006874 9.46 CASR GCM2 PTH PTH1R
15 parathyroid gland development GO:0060017 9.43 GATA3 GCM2
16 response to fibroblast growth factor GO:0071774 9.4 CASR PTH
17 cAMP metabolic process GO:0046058 9.32 PTH PTHLH
18 osteoblast development GO:0002076 9.13 BGLAP PTH1R PTHLH
19 cellular response to vitamin D GO:0071305 8.8 BGLAP CASR FGF23

Molecular functions related to Hypoparathyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Hypoparathyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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