MCID: HYP024
MIFTS: 53

Hypoparathyroidism malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoparathyroidism

Aliases & Descriptions for Hypoparathyroidism:

Name: Hypoparathyroidism 12 50 29 52 42 14 69
Hypoparathyroidism, Idiopathic 50
Parathyroid, Underactivity of 50

Classifications:



External Ids:

Disease Ontology 12 DOID:11199
ICD10 33 E20 E20.9 E20.0
ICD9CM 35 252.1
MeSH 42 D007011
NCIt 47 C78350
UMLS 69 C0020626

Summaries for Hypoparathyroidism

NIH Rare Diseases : 50 hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (pth). common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). it may be caused by injury to the parathyroid glands (e.g., during surgery). other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, digeorge syndrome, and type i polyglandular autoimmune syndrome. the goal of treatment is to restore the calcium and mineral balance in the body. last updated: 3/10/2011

MalaCards based summary : Hypoparathyroidism, also known as hypoparathyroidism, idiopathic, is related to pseudohypoparathyroidism, type ib and hypoparathyroidism-retardation-dysmorphism syndrome. An important gene associated with Hypoparathyroidism is GCM2 (Glial Cells Missing Homolog 2), and among its related pathways/superpathways are G alpha (s) signalling events and Endochondral Ossification. The drugs Betamethasone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and thyroid, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.

Wikipedia : 71 Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid... more...

Related Diseases for Hypoparathyroidism

Diseases in the Hypoparathyroidism family:

Secondary Hypoparathyroidism Due to Impaired Parathormon Secretion Autoimmune Hypoparathyroidism

Diseases related to Hypoparathyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
id Related Disease Score Top Affiliating Genes
1 pseudohypoparathyroidism, type ib 29.9 PRKAR1A PTH
2 hypoparathyroidism-retardation-dysmorphism syndrome 12.3
3 hypoparathyroidism, familial isolated 12.3
4 hypoparathyroidism, sensorineural deafness, and renal dysplasia 12.2
5 hypoparathyroidism-deafness-renal disease syndrome 12.1
6 hypoparathyroidism-intellectual disability-dysmorphism syndrome 12.1
7 autoimmune hypoparathyroidism 12.0
8 hypoparathyroidism, x-linked 11.9
9 secondary hypoparathyroidism due to impaired parathormon secretion 11.8
10 lymphedema-hypoparathyroidism syndrome 11.7
11 hypocalcemia, autosomal dominant 11.7
12 casr-associated familial isolated hypoparathyroidism 11.7
13 casr-related familial isolated hypoparathyroidism 11.7
14 gcm2-related familial isolated hypoparathyroidism 11.7
15 pth-related familial isolated hypoparathyroidism 11.7
16 hypoparathyroidism short stature mental retardation 11.7
17 autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia 11.5
18 autoimmune polyendocrine syndrome type 1 11.5
19 pseudohypoparathyroidism 11.4
20 kearns-sayre syndrome 11.1
21 pseudohypoparathyroidism ic 11.1
22 pseudopseudohypoparathyroidism 11.0
23 dahlberg borer newcomer syndrome 10.8
24 ossification of the posterior longitudinal ligament of spine 10.7
25 kenny-caffey syndrome, type 2 10.7
26 kenny-caffey syndrome, type 1 10.7
27 velocardiofacial syndrome 10.7
28 macrocephaly/megalencephaly syndrome, autosomal recessive 10.3 GCM2 PTH
29 bladder flat intraepithelial lesion 10.3 GATA3 PTH
30 striatonigral degeneration 10.3 CASR PTH
31 mesenchymal cell neoplasm 10.2 CASR PTH
32 toxicodendron dermatitis 10.2 PTH PTHLH
33 lacrimal duct obstruction 10.2 GATA3 TBCE
34 malignant granular cell myoblastoma 10.2 PTH PTHLH
35 prune belly syndome 10.2 GATA3 GCM2 PTH
36 cerebrooculofacioskeletal syndrome 4 10.2 CASR PTHLH
37 deafness, autosomal recessive 29 10.2 AIRE CASR
38 mixed germ cell cancer 10.2 PTH PTHLH
39 jessner's lymphocytic infiltration of the skin 10.2 CASR PRKAR1A
40 orbit lymphoma 10.2 FGF23 PTH
41 epilepsy idiopathic generalized 8 10.2 CASR PRKAR1A
42 nemaline myopathy 3, autosomal dominant or recessive 10.2 FAM111A PTH TBCE
43 thyroiditis 10.2
44 renal dysplasia 10.2
45 familial chronic myelocytic leukemia-like syndrome 10.1 CASR PTH SPG7
46 eiken syndrome 10.1 PTH PTH1R
47 uterine corpus endometrial stromal sarcoma 10.1 GATA3 PTHLH
48 strabismus 10.1 GATA3 PTH PTHLH
49 joubert syndrome 9 10.1 FGF23 PTH
50 progressive locomotor ataxia 10.1 FGF23 PTHLH

Comorbidity relations with Hypoparathyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hyperparathyroidism
Hypertension, Essential Hypothyroidism
Postsurgical Hypothyroidism

Graphical network of the top 20 diseases related to Hypoparathyroidism:



Diseases related to Hypoparathyroidism

Symptoms & Phenotypes for Hypoparathyroidism

MGI Mouse Phenotypes related to Hypoparathyroidism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 GATA3 GCM2 PRKAR1A PTH PTHLH AIRE
2 growth/size/body region MP:0005378 9.97 FGF23 GATA3 PRKAR1A PTH PTH1R PTHLH
3 digestive/alimentary MP:0005381 9.95 AIRE CASR FGF23 GATA3 PRKAR1A PTH1R
4 craniofacial MP:0005382 9.91 GATA3 GCM2 PRKAR1A PTH PTH1R PTHLH
5 homeostasis/metabolism MP:0005376 9.91 CASR FGF23 GATA3 GCM2 PRKAR1A PTH
6 mortality/aging MP:0010768 9.85 AIRE CASR FGF23 GATA3 GCM2 PRKAR1A
7 respiratory system MP:0005388 9.43 AIRE FGF23 PRKAR1A PTH1R PTHLH TBCE
8 skeleton MP:0005390 9.28 CASR FGF23 GATA3 GCM2 PRKAR1A PTH

Drugs & Therapeutics for Hypoparathyroidism

Drugs for Hypoparathyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 129)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
6
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
7 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Ergocalciferols Phase 4,Phase 3
10 Micronutrients Phase 4,Phase 3,Phase 2
11 Trace Elements Phase 4,Phase 3,Phase 2
12 vitamin d Phase 4,Phase 3,Phase 2
13 Vitamins Phase 4,Phase 2,Phase 3
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
18 glucocorticoids Phase 4,Phase 1,Phase 2
19 Anti-Asthmatic Agents Phase 4
20 Betamethasone acetate Phase 4
21 Betamethasone benzoate Phase 4
22 Betamethasone sodium phosphate Phase 4
23 Betamethasone Valerate Phase 4 2152-44-5
24 Betamethasone-17,21-dipropionate Phase 4
25 Respiratory System Agents Phase 4
26 Antipsychotic Agents Phase 4
27 Central Nervous System Depressants Phase 4
28 Central Nervous System Stimulants Phase 4
29 Dopamine Agents Phase 4
30 Dopamine Antagonists Phase 4
31 Dopamine Uptake Inhibitors Phase 4
32 Neurotransmitter Agents Phase 4
33 Neurotransmitter Uptake Inhibitors Phase 4
34 Psychotropic Drugs Phase 4
35
Serotonin Phase 4 50-67-9 5202
36 Serotonin Agents Phase 4
37 Serotonin Antagonists Phase 4
38 Tranquilizing Agents Phase 4
39 Calciferol Nutraceutical Phase 4,Phase 3
40 Vitamin D2 Nutraceutical Phase 4,Phase 3
41
Teriparatide Approved, Investigational Phase 2, Phase 3 52232-67-4 16133850
42
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-02-9 14985
44 Coagulants Phase 3
45 Hemostatics Phase 3
46 Tocopherols Phase 2, Phase 3
47 Tocotrienols Phase 2, Phase 3
48 11-hydroxyprogesterone Phase 3
49 17-alpha-hydroxy-progesterone caproate Phase 3
50 Progestins Phase 3

Interventional clinical trials:

(show top 50) (show all 85)
id Name Status NCT ID Phase
1 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4
2 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Recruiting NCT02652884 Phase 4
3 Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism Recruiting NCT02910466 Phase 4
4 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4
5 Vitamin D Deficiency and Postoperative Hypocalcemia Active, not recruiting NCT01632514 Phase 4
6 ADD-ON Study to Existing Hypoparathyroidism Studies Unknown status NCT00856401 Phase 3
7 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
8 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
9 Use of NPSP558 in the Treatment of Hypoparathyroidism Completed NCT00732615 Phase 3
10 Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY) Completed NCT01268098 Phase 3
11 A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary Completed NCT01455181 Phase 3
12 Bone Properties in Hypoparathyroidism: Effects of PTH Completed NCT00473265 Phase 2, Phase 3
13 A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE) Active, not recruiting NCT01297309 Phase 3
14 HEXT (Hypo EXTended): Effect of PTH on Skeleton in Hypoparathyroidism Active, not recruiting NCT01199614 Phase 3
15 Effects of PTH Replacement on Bone in Hypoparathyroidism Active, not recruiting NCT00395538 Phase 3
16 Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer Active, not recruiting NCT01608451 Phase 3
17 Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life Completed NCT00730210 Phase 2
18 Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34 Completed NCT00001304 Phase 2
19 A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients Completed NCT01815021 Phase 1, Phase 2
20 A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism Completed NCT02152228 Phase 2
21 Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery Completed NCT02089542 Phase 1, Phase 2
22 A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations Completed NCT02204579 Phase 2
23 Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Autosomal Dominant Hypocalcemia Recruiting NCT02824718 Phase 2
24 Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer Recruiting NCT02138214 Phase 2
25 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2
26 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2
27 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
28 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
29 Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2
30 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2
31 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1
32 Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Subjects With Hypoparathyroidism Recruiting NCT02781844 Phase 1
33 Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects Recruiting NCT03150108 Phase 1
34 EIS in Thyroid and Parathyroid Surgery Recruiting NCT02901873 Phase 1
35 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
36 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
37 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
38 Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy Unknown status NCT01039714
39 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955
40 Genetics and Psychopathology in the 22q11 Deletion Syndrome Unknown status NCT00161109
41 Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome Unknown status NCT00005102
42 Hypoparathyroidism in Denmark Completed NCT01498341
43 Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy Completed NCT02924532
44 Magnesium Treatment in Hypoparathyroidism Completed NCT00824226
45 Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism Completed NCT00743782 Early Phase 1
46 Perioperative Parathormone Measurement and Sodium Bicarbonate Infusion Test After Total Thyroidectomy Completed NCT00793689
47 Physiologic Regulation of FGF-23 Completed NCT00356512
48 Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects Completed NCT00004361
49 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
50 Determinants of Thyroid Surgery Outcomes Completed NCT02813733

Search NIH Clinical Center for Hypoparathyroidism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypoparathyroidism

Genetic Tests for Hypoparathyroidism

Genetic tests related to Hypoparathyroidism:

id Genetic test Affiliating Genes
1 Hypoparathyroidism 29

Anatomical Context for Hypoparathyroidism

MalaCards organs/tissues related to Hypoparathyroidism:

39
Kidney, Testes, Thyroid, Bone, Skin, Brain, Heart

Publications for Hypoparathyroidism

Articles related to Hypoparathyroidism:

(show top 50) (show all 720)
id Title Authors Year
1
A Novel De novo GATA-binding Protein 3 Mutation in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome. ( 28524840 )
2017
2
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. ( 28051179 )
2017
3
Failure of fragmented parathyroid gland autotransplantation to prevent permanent hypoparathyroidism after total thyroidectomy. ( 28064342 )
2017
4
A Case of Primary Hypoparathyroidism Presenting with Acute Kidney Injury Secondary to Rhabdomyolysis. ( 27034860 )
2016
5
Hypoparathyroidism after total thyroidectomy: prospective evaluation and relation with early hypocalcemia. ( 27346692 )
2016
6
Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require antiepileptic drugs. ( 27957632 )
2016
7
An unusual case of hypercalcemia in a patient of concomitant hypoparathyroidism and celiac disease. ( 27252747 )
2016
8
Postoperative Hypoparathyroidism and the Viability of the Parathyroid Glands During Thyroidectomy. ( 27515510 )
2016
9
Management of Hypoparathyroidism: Present and Future. ( 26938200 )
2016
10
Good's syndrome and hypoparathyroidism combined with hypocalcaemia, hypokalemia, hypomagnesemia, and hypophosphatemia-Case report. ( 26875773 )
2016
11
Refractory Hypoparathyroidism in a Child with Celiac Disease. ( 26964284 )
2016
12
Presence of Auto-reactive, MHC class-I restricted, Calcium Sensing Receptor (CaSR) specific CD8(+) T cells in Idiopathic Hypoparathyroidism. ( 27805845 )
2016
13
Hip Pain and Gait Disturbance Associated with Idiopathic Hypoparathyroidism. ( 27190909 )
2016
14
Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2. ( 27803672 )
2016
15
Seizure and tetany secondary to hypomagnesaemic hypoparathyroidism induced by a proton-pump inhibitor. ( 27896379 )
2016
16
Proton pump inhibitors and symptomatic hypomagnesemic hypoparathyroidism. ( 27206762 )
2016
17
Idiopathic Hypoparathyroidism Mimicking Ankylosing Spondylitis: A Case Report. ( 27115113 )
2016
18
Vertebral fractures and bone mineral density in patients with idiopathic hypoparathyroidism on long term follow-up. ( 27813708 )
2016
19
Chronic Hypoparathyroidism Due to Partial Thyroidectomy with Intracranial Calcification. ( 27241548 )
2016
20
Management of Hypoparathyroidism: Summary Statement and Guidelines. ( 26943719 )
2016
21
Therapy of Hypoparathyroidism with PTH(1-84): a Prospective Six Year Investigation of Efficacy and Safety. ( 27144931 )
2016
22
Extensive bilateral striopallidodentate calcinosis: a 50A years history of hypoparathyroidism presenting like a parkinsonian syndrome. ( 27485169 )
2016
23
Identification of autoimmune polyendocrine syndrome type 1 in patients with isolated hypoparathyroidism. ( 27219120 )
2016
24
The deceptive concept of hypoparathyroidism and recurrence after parathyroidectomy in dialysis patients: are we offering a Procrustean bed to some patients? ( 27982325 )
2016
25
Bone imaging in hypoparathyroidism. ( 27577725 )
2016
26
The risk of hypoparathyroidism after central compartment lymph node dissection in the surgical treatment of pT1, N0 thyroid papillary carcinoma. ( 27212170 )
2016
27
Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. ( 27857062 )
2016
28
Long-term outcome of cataract surgery in patients with idiopathic hypoparathyroidism and its relationship with their calcemic status. ( 27465913 )
2016
29
Short-Term PTH(1-34) Therapy in Children to Correct Severe Hypocalcemia and Hyperphosphatemia due to Hypoparathyroidism: Two Case Studies. ( 27957353 )
2016
30
Clinical and mutational spectrum of hypoparathyroidism, deafness and renal dysplasia syndrome. ( 27387476 )
2016
31
Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications. ( 27901178 )
2016
32
Parathyroid Hormone Replacement Therapy in Hypoparathyroidism: A Meta-Analysis. ( 27254756 )
2016
33
Hypercalcemia due to Milk-Alkali Syndrome and Fracture-Induced Immobilization in an Adolescent Boy with Hypoparathyroidism. ( 27184240 )
2016
34
The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study. ( 28012105 )
2016
35
Epidemiology and health related quality of life in hypoparathyroidism in Norway. ( 27186861 )
2016
36
Fahr's Syndrome and Secondary Hypoparathyroidism. ( 27141572 )
2016
37
Long-Term Follow-Up and Treatment of Postoperative Permanent Hypoparathyroidism in Patients with Medullary Thyroid Carcinoma: Differences in Complete and Partial Disease. ( 27813050 )
2016
38
Treatment of severe life threatening hypocalcemia with recombinant human teriparatide in patients with postoperative hypoparathyroidism - a case series. ( 27387245 )
2016
39
Adipose-derived stem cells: A novel source of parathyroid cells for treatment of hypoparathyroidism. ( 27372875 )
2016
40
Hypoparathyroidism and pregnancy. ( 27172871 )
2016
41
Allotransplantation of macroencapsulated parathyroid cells as a treatment of severe postsurgical hypoparathyroidism: case report. ( 26997532 )
2016
42
Living-donor parathyroid allotransplantation for therapy-refractory postsurgical persistent hypoparathyroidism in a nontransplant recipient - three year results: a case report. ( 27488573 )
2016
43
Case of extensive basal ganglia calcification-Rare finding of Idiopathic Hypoparathyroidism. ( 27728189 )
2016
44
Computed tomography anomalies associated with isolated hypoparathyroidism. ( 27980765 )
2016
45
Coexistence of cutaneous phosphaturic mesenchymal tumour and postoperative hypoparathyroidism. ( 27032881 )
2016
46
Presentation of Hypoparathyroidism: Etiologies and Clinical Features. ( 26943721 )
2016
47
Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism. ( 27942265 )
2016
48
Hypoparathyroidism - a rare mimicker of amyotrophic lateral sclerosis. ( 27514792 )
2016
49
Organic psychosis due to hypoparathyroidism in an older adult: a case report. ( 27828563 )
2016
50
A case of brain calcifications in postsurgical hypoparathyroidism. ( 26968176 )
2016

Variations for Hypoparathyroidism

Expression for Hypoparathyroidism

Search GEO for disease gene expression data for Hypoparathyroidism.

Pathways for Hypoparathyroidism

Pathways related to Hypoparathyroidism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.6 PTH PTH1R PTHLH
2 11.14 PTH PTH1R PTHLH
3 10.52 PRKAR1A PTH PTH1R PTHLH
4 10.28 FGF23 PTH PTH1R

GO Terms for Hypoparathyroidism

Biological processes related to Hypoparathyroidism according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.67 PTH PTH1R PTHLH
2 cell maturation GO:0048469 9.54 GATA3 PTH1R
3 developmental growth GO:0048589 9.52 GATA3 TBCE
4 bone resorption GO:0045453 9.51 PTH PTH1R
5 osteoblast development GO:0002076 9.48 PTH1R PTHLH
6 negative regulation of chondrocyte differentiation GO:0032331 9.46 PTH PTHLH
7 cellular response to vitamin D GO:0071305 9.43 CASR FGF23
8 cellular phosphate ion homeostasis GO:0030643 9.4 FGF23 GCM2
9 positive regulation of inositol phosphate biosynthetic process GO:0060732 9.37 PTH PTH1R
10 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.33 PTH PTH1R PTHLH
11 parathyroid gland development GO:0060017 9.32 GATA3 GCM2
12 response to fibroblast growth factor GO:0071774 9.26 CASR PTH
13 cAMP metabolic process GO:0046058 8.96 PTH PTHLH
14 cellular calcium ion homeostasis GO:0006874 8.92 CASR GCM2 PTH PTH1R

Molecular functions related to Hypoparathyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Hypoparathyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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