Hypoparathyroidism malady

NIH Rare Diseases: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.³⁰

MalaCards: Hypoparathyroidism, also known as hypoparathyroidism, idiopathic (subtype), is related to hypoparathyroidism familial isolated and hypoparathyroidism, autosomal dominant. An important gene associated with Hypoparathyroidism is PTH (parathyroid hormone), and among its related pathways are Class B/2 (Secretin family receptors) and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drug ergocalciferol and the compounds cinacalcet and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and skin, and related mouse phenotypes are hematopoietic system and craniofacial.

Wikipedia: Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid...⁴⁴ more...

Aliases & Descriptions:

hypoparathyroidism 6 7 30 8 32 43 hypoparathyroidism, idiopathic (subtype) 30 hypoparathyroidism nos (disorder) 6

parathyroid, underactivity of 30 hypoparathyroidism (disorder) 6

Diseases related to hypoparathyroidism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 398)

id	Related Disease	Score	Top Affiliating Genes
1	hypoparathyroidism familial isolated	31.7	GCM2, PTH
2	hypoparathyroidism, autosomal dominant	30.4	GCM2, CASR, PTH
3	autoimmune polyendocrine syndrome type 1	30.1	CASR, AIRE, NLRP5
4	pseudohypoparathyroidism type 1b	29.8	GNAS, PTHLH
5	hdr syndrome	29.2	ZFPM2, GATA3
6	pseudohypoparathyroidism	28.6	NAGLU, BGLAP, IGF1, GNAS, CALCA, PTH
7	parathyroid disorders	28.2	PTH, PTHLH
8	hypothyroidism	27.5	RET, CALCA, AIRE, TPO
9	hypomagnesemia	27.3	BGLAP, INS, CASR, GATA3
10	hypercalcemia	26.8	VDR, BGLAP, FGF23, IGF1, ALPP, CARS
11	hypercalciuria	25.9	NAGLU, VDR, BGLAP, FGF23, CASR, CALCA
12	hypocalcemia	25.6	PIK3C2A, GCM2, VDR, BGLAP, FGF23, ALPP
13	leukemia/lymphoma	25.5	BGLAP, MTHFR, IL2RA, CALCA, DYT10, PTHLH
14	hyperhomocysteinemia	25.2	MTHFR, INS, IGF1, F9, CASR
15	beta thalassemia	24.4	NAGLU, VDR, BGLAP, MTHFR, INS, IGF1
16	short stature	23.9	VDR, BGLAP, INS, FGF23, IGF1, ALPP
17	osteoarthritis	23.4	VDR, BGLAP, INS, IL2RA, MCF2L, IGF1
18	thalassemia	22.8	PIK3C2A, NAGLU, VDR, BGLAP, MTHFR, INS
19	hyperparathyroidism	22.0	RET, GCM2, VDR, BGLAP, INS, FGF23
20	diabetes mellitus	20.9	PIK3C2A, RET, NAGLU, VDR, BGLAP, MTHFR
21	thyroiditis	19.3	PIK3C2A, RET, GCM2, NAGLU, VDR, ZFPM2
22	leukemia	18.0	PIK3C2A, VDR, BGLAP, MTHFR, INS, FGF23
23	parathyroid carcinoma	13.8	CASR, PTH, CXADR
24	clear cell adenoma	13.8	ALPP, PTH
25	familial isolated hyperparathyroidism	13.7	RET, CASR, PTH
26	ollier disease	13.7	PTH1R, PTHLH
27	parathyroid gland disease	13.7	RET, CASR, AIRE
28	familial hypocalciuric hypercalcemia	13.7	CASR, SPG7, NR1I3, CXADR
29	hyperparathyroidism, neonatal severe primary	13.7	CASR, NR1I3, PRKAR1A, CXADR
30	jansen's metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTH1R, PTHLH
31	metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTH1R, PTHLH
32	oncogenic osteomalacia	13.6	FGF23, CALCA, PTH, PTH1R
33	multiple endocrine neoplasia type 2a	13.6	RET, CALCA, PTH
34	hypocalcemia, autosomal dominant	13.6	CARS, CASR, PRKAR1A, CXADR
35	dysgerminoma of ovary	13.6	ALPP, PTHLH
36	paraneoplastic syndromes	13.6	FGF23, CALCA, AIRE, PTHLH
37	osteochondrodysplasia	13.6	BGLAP, PTH1R, PTHLH
38	familial medullary thyroid carcinoma	13.6	RET, CALCA
39	paget's disease of bone	13.6	BGLAP, CALCA
40	osteosclerosis	13.6	BGLAP, ALPP, AIRE, PTH, TBCE
41	metaphyseal dysplasia	13.5	AIRE, PTH, PTH1R, PTHLH, RMRP
42	progressive osseous heteroplasia	13.5	BGLAP, ALPP, GNAS
43	wermer syndrome	13.5	GNAS, PTH, PRKAR1A
44	hypophosphatasia	13.5	ALPP, CALCA, SLPI
45	humoral hypercalcemia of malignancy	13.4	BGLAP, FGF23, CASR, PTH1R, PTHLH, NR1I3
46	giant cell tumor	13.4	BGLAP, FGF23, CALCA
47	hypervitaminosis d	13.4	VDR, FGF23, PTH
48	vitamin d-dependent rickets type ii	13.4	VDR, BGLAP, PTH
49	hypocalciuric hypercalcemia	13.4	CASR, CALCA, PTH, SPG7, NR1I3, PRKAR1A
50	chst3-related skeletal dysplasia	13.4	GNAS, PTH1R, PTHLH, RMRP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 ergocalciferol

MalaCards organs/tissues related to hypoparathyroidism:

²²

MGI Mouse Phenotypes related to hypoparathyroidism:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.5	GATA3, CXADR, PRKAR1A, TBX1, PTHLH, PTPN22
2	craniofacial phenotype	MP:0005382	9.4	GATA3, PRKAR1A, TBX1, PTH1R, PTH, GNAS
3	endocrine/exocrine gland phenotype	MP:0005379	9.3	PRKAR1A, CTLA4, TBX1, PTH, AIRE, GNAS
4	respiratory system phenotype	MP:0005388	9.3	PRKAR1A, TBX1, TBCE, PTPN22, PTH1R, CALCA
5	integument phenotype	MP:0010771	8.9	GATA3, SNCA, CTLA4, TBX1, PTHLH, CALCA
6	embryogenesis phenotype	MP:0005380	8.8	GATA3, HADHA, CXADR, PRKAR1A, NLRP5, TBX1
7	reproductive system phenotype	MP:0005389	8.7	PRKAR1A, NLRP5, SNCA, NR1I3, ALPP, FGF23
8	limbs/digits/tail phenotype	MP:0005371	8.7	TBX1, PTHLH, PTH, GNAS, FGF23, MTHFR
9	immune system phenotype	MP:0005387	8.6	PTPN22, PTHLH, TBX1, PRKAR1A, CXADR, PTH
10	liver/biliary system phenotype	MP:0005370	8.5	HADHA, NR1I3, CTLA4, PTPN22, AIRE, GLA
11	renal/urinary system phenotype	MP:0005367	8.0	GLA, PTHLH, SNCA, HADHA, GATA3, CASR
12	nervous system phenotype	MP:0003631	7.7	TBCE, TBX1, SPG7, SNCA, PTHLH, AIRE
13	digestive/alimentary phenotype	MP:0005381	7.4	PTHLH, TBX1, CTLA4, SNCA, PRKAR1A, CXADR
14	normal phenotype	MP:0002873	7.4	TBX1, CTLA4, PRKAR1A, RMRP, GATA3, AIRE
15	behavior/neurological phenotype	MP:0005386	7.0	PTHLH, TBCE, TBX1, SPG7, SNCA, CXADR
16	cardiovascular system phenotype	MP:0005385	6.3	PTHLH, TBX1, CTLA4, SNCA, PRKAR1A, CXADR
17	skeleton phenotype	MP:0005390	6.2	PTH1R, PTHLH, TBX1, SPG7, CTLA4, SNCA
18	mortality/aging	MP:0010768	5.6	PIK3C2A, PTPN22, TBCE, TBX1, CTLA4, NR1I3
19	cellular phenotype	MP:0005384	5.4	PTPN22, PTHLH, TBX1, CTLA4, NR1I3, SNCA
20	growth/size phenotype	MP:0005378	5.3	TBX1, PTHLH, PTPN22, PTH1R, SPG7, NR1I3
21	homeostasis/metabolism phenotype	MP:0005376	4.3	TBX1, PTHLH, PTPN22, PTH1R, TPO, CTLA4

Articles related to hypoparathyroidism:

(show top 50)    (show all 88)

id	Title	Authors	Year	Affiliating Genes
1	AIRE gene mutations and autoantibodies to interferon omega in patients with chronic hypoparathyroidism without APECED. (20718774)	Cervato S.... Betterle C.	2010	AIRE
2	Identification and characterization of novel parathyr oid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutation s in eight families with autosomal recessive hypoparathyroidism. (20190276)	Bowl M.R.... Thakker R.V.	2010	GCM2
3	Presence and significance of a R110W mutation in the DNA-binding domain of GCM2 gene in patients with isolated hypoparathyroidism an d their family members. (19940031)	Tomar N.... Goswami R.	2010	GCM2
4	Intragenic GNAS deletion involving exon A/B in pseudo hypoparathyroidism type 1A resulting in an apparent loss of exon A/B methylatio n: potential for misdiagnosis of pseudohypoparathyroidism type 1B. (20008020)	Fernandez-Rebollo E.... PAcrez de Nanclares G.	2010	GNAS
5	Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism. (19328421)	Brown E.M.	2009	CASR
6	Autoimmune hypoparathyroidism in a 12-year-old girl w ith McKusick cartilage hair hypoplasia. (19626344)	Bacchetta J.... Peretti N.	2009	RMRP
7	Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism. (18712808)	Canaff L.... Hendy G.N.	2009	CASR, GCM2
8	Autosomal dominant hypoparathyroidism with severe hypomagnesemia and hypocalcemia, successfully treated with recombinant PTH and continuous subcutaneous magnesium infusion. (18556971)	Sanda S.... Newfield R.S.	2008	CASR
9	Successful treatment of vitamin D unresponsive hypoparathyroidism with multipulse subcutaneous infusion of teriparatide. (18703565)	Puig-Domingo M.... Halperin I.	2008	PTH
10	Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. (18018479)	Preusser M.... Brugger S.	2007	SNCA
11	Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone. (18056632)	Datta R.... Sly W.S.	2007	PTH
12	Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor. (17210674)	Ali A.... Thakker R.V.	2007	GATA3
13	A novel mutation in the GATA3 gene in a family with HDR syndrome (Hypoparathyroidism, sensorineural Deafness and Renal anomaly syndrome). (16509533)	Adachi M.... Tsuchiya T.	2006	GATA3
14	Hypoparathyroidism-retardation-dysmorphism syndrome in a girl: A new variant not caused by a TBCE mutation--clinical report and review. (16470743)	Courtens W.... Parvari R.	2006	TBCE
15	A common structural mechanism underlying GCMB mutations that cause hypoparathyroidism. (16697534)	Sticht H.... Hashemolhosseini S.	2006	GCM2
16	A novel heterozygous deletion frameshift mutation of GATA3 in a Japanese kindred with the hypoparathyroidism, deafness and renal dysplasia syndrome. (17114920)	Kobayashi H.... Ogawa Y.	2006	GATA3
17	Absence of pathogenic calcium sensing receptor mutations in sporadic idiopathic hypoparathyroidism. (16918956)	Sarin R.... Goswami R.	2006	CASR
18	Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians. (16893384)	Ray D.... Goswami R.	2006	PTPN22
19	Effect of parathyroid hormone administration in a patient with severe hypoparathyroidism caused by gain-of-function mutation of calcium-sensing receptor. (16983178)	Shiohara M.... Koike K.	2006	CASR, CXADR
20	antiphospholipid antibodies syndrome associated with hyperhomocysteinemia related to MTHFR Gene C677T and A1298C heterozygous mutations in a young man with idiopathic hypoparathyroidism (DiGeorge syndrome). (16595601)	Nucera C.... Vermiglio F.	2006	MTHFR
21	GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone. (15728199)	Thomee C.... Abramowicz M.J.	2005	GCM2
22	Functional analysis of a novel GATA3 mutation in a family with the hypoparathyroidism, deafness, and renal dysplasia syndrome. (15705923)	Zahirieh A.... Pei Y.	2005	GATA3
23	X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. (15533723)	Andrew-Nesbit M.... Thakker R.V.	2004	MCF2L, ATP11A, ATP11C
24	Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. (14713274)	Goswami R.... Chattopadhyay N.	2004	TPO, CASR
25	Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism. (15356052)	Mayer A.... Fabien N.	2004	CASR
26	A novel gain-of-function mutation (F821L) in the transmembrane domain of calcium-sensing receptor is a cause of severe sporadic hypoparathyroidism. (14677060)	Shiohara M.... Yasuda T.	2004	CASR, CXADR
27	Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. (12389028)	Parvari R.... Gelb B.D.	2002	TBCE
28	Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. (11972098)	Chern J.P.... Lin K.H.	2002	INS
29	Familial hypoparathyroidism due to activating mutations in the calcium-sensing receptor gene (11857922)	Watanabe T.... Minagawa M.	2002	CASR
30	Fabry's disease and hypoparathyroidism (12218896)	Misery L.... Cambazard F.	2002	GLA
31	Comparison of hypocalcemic hypercalciuria between patients with idiopathic hypoparathyroidism and those with gain-of-function mutations in the calcium-sensing receptor: is it possible to differentiate the two disorders? (11134112)	Yamamoto M.... Ogata E.	2000	CASR, SPG7
32	Hypercalcemia in a woman with hypoparathyroidism associated with increased parathyroid hormone-related protein during lactation. (15251676)	Shomali M.E.... Ross D.S.	1999	PTHLH
33	Symptomatic hypocalcaemia in hypermagnesaemia-induced hypoparathyroidism, during magnesium tocolytic therapy--possible involvement of the calcium-sensing receptor. (10435892)	Mayan H.... Farfel Z.	1999	CASR
34	BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients. (10478142)	Tagliabue J.... Annoni G.	1999	VDR
35	Familial hypoparathyroidism: identification of a novel gain of function mutation in transmembrane domain 5 of the calcium-sensing receptor. (9661634)	Watanabe T.... Yasuda T.	1998	CARS, CASR, CXADR
36	A randomized, cross-over trial of once-daily versus twice-daily parathyroid hormone 1-34 in treatment of hypoparathyroidism. (9768650)	Winer K.K.... Cutler G.B.	1998	PTH, NR1I3
37	A Ca(2+)-sensing receptor mutation causes hypoparathyroidism by increasing receptor sensitivity to Ca2+ and maximal signal transduction. (9380434)	Mancilla E.E.... Baron J.	1997	SPG7
38	Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor. (9253358)	De Luca F.... Baron J.	1997	CASR, SPG7
39	Low calcium (1.25 mmol/L) dialysate can normalize relative hypoparathyroidism in CAPD patients with low bone turnover. (8865914)	Shigematsu T.... Sakai O.	1996	BGLAP
40	Familial isolated hypoparathyroidism: case report with serum PTHrP examination. (8980898)	Koshiyama H.... Katakami H.	1996	PTHLH
41	Antibodies targeting the calcium sensing receptor: acquired hypoparathyroidism--an autoimmune disease at last? (8810727)	Hofbauer L.C.... Heufelder A.E.	1996	CASR
42	Mutations in the Ca(2+)-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism. (8733126)	Baron J.... Cutler G.B. Jr.	1996	CASR
43	Preliminary localization of a gene for autosomal dominant hypoparathyroidism to chromosome 3q13. (7808841)	Finegold D.N.... Ferrell R.E.	1994	PTH
44	A case of idiopathic hypoparathyroidism associated w ith primary hypothyroidism and diabetes mellitus (7958110)	Sumida Y.... Shima T.	1994	INS
45	Progressively increased serum 1,25-dihydroxyvitamin D2 concentration in a hypoparathyroid patient with protracted hypercalcemia due to vitamin D2 intoxication. (8528347)	Sato K.... Kobayashi T.	1994	CALCA
46	Serum striated muscle enzymes in autoimmune hypoparathyroidism (8253399)	Waysbort Y.... Askenazy B.	1993	PIK3C2A
47	A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism. (1302009)	Parkinson D.B.... Thakker R.V.	1992	PTH
48	T-lymphocyte activation in adult-onset idiopathic hypoparathyroidism. (1348395)	Wortsman J.... Mallette L.E.	1992	IL2RA
49	A case of idiopathic hypoparathyroidism with extrapyramidal signs and insulin-dependent diabetes mellitus (2225658)	Okuda S.... Muroga T.	1990	INS
50	Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. (2212001)	Arnold A.... Kronenberg H.M.	1990	PTH

Genes related to hypoparathyroidism according to GeneCards:

(show all 47)

id	Symbol	Description	Score	GeneCards Section Context
1	PTH	parathyroid hormone	11.1	Publications, Summaries
2	GCM2	glial cells missing homolog 2 (Drosophila)	11.1	Summaries, Publications
3	GATA3	GATA binding protein 3	11.1	Summaries, Publications
4	CASR	calcium-sensing receptor	11.1	Summaries, Publications
5	HPT	hypoparathyroidism	11.1	Publications, Aliases & Descriptions
6	HRD	hypoparathyroidism, growth and mental retardation, and dysmorphism	11.0	Publications, Aliases & Descriptions
7	TBCE	tubulin folding cofactor E	11.0	Publications
8	AIRE	autoimmune regulator	11.0	Publications
9	SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	11.0	Publications
10	FGF23	fibroblast growth factor 23	11.0	Publications
11	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
12	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
13	CXADR	coxsackie virus and adenovirus receptor	11.0	Publications
14	PTH1R	parathyroid hormone 1 receptor	11.0
15	PTHLH	parathyroid hormone-like hormone	11.0	Publications
16	F9	coagulation factor IX	11.0
17	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
18	ALPP	alkaline phosphatase, placental	11.0	Publications
19	NAGLU	N-acetylglucosaminidase, alpha	11.0
20	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
21	RET	ret proto-oncogene	11.0
22	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
23	RMRP	RNA component of mitochondrial RNA processing endoribonuclease	11.0	Publications
24	ZNF2	zinc finger protein 2	11.0	Disorders
25	CARS	cysteinyl-tRNA synthetase	11.0	Publications
26	ATP11C	ATPase, class VI, type 11C	11.0	Publications
27	GLA	galactosidase, alpha	11.0	Publications
28	TBX1	T-box 1	11.0
29	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0	Publications
30	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
31	ATP11B	ATPase, class VI, type 11B	11.0	Disorders
32	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
33	DGCR2	DiGeorge syndrome critical region gene 2	11.0
34	MCF2L	MCF.2 cell line derived transforming sequence-like	11.0	Publications
35	NLRP5	NLR family, pyrin domain containing 5	11.0
36	TPO	thyroid peroxidase	11.0	Publications
37	ZFPM2	zinc finger protein, multitype 2	11.0	Publications
38	ATP11A	ATPase, class VI, type 11A	11.0	Publications
39	GNAS	GNAS complex locus	11.0	Publications
40	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
41	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
42	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
43	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
44	DYT10	dystonia 10	11.0	Publications
45	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
46	INS	insulin	11.0	Publications
47	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications

Pathways related to hypoparathyroidism according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Class B/2 (Secretin family receptors)38	9.7	GNAS, CALCA, PTH, PTH1R, PTHLH
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.3	VDR, PRKAR1A, PTHLH, PTH1R, PTH, GNAS
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.2	PRKAR1A, PTHLH, PTH1R, PTH, GNAS, BGLAP
4	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	PTH1R, PTH, CALCA, IGF1, BGLAP, VDR
5	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.8	PTH1R, PTH, CALCA, IGF1, BGLAP, VDR

Compounds related to hypoparathyroidism according to GeneDecks:

(show top 50)    (show all 143)

id	Compound	Score	Top Affiliating Genes
1	cinacalcet32 9 9	12.2	CALCA, CASR, NR1I3, PRKAR1A, CXADR
2	calcium carbonate32	10.2	CALCA, BGLAP, ALPP, PTH, PTHLH
3	pamidronate32 9 9	12.2	CALCA, BGLAP, PTHLH, ALPP, CASR, PTH
4	ipriflavone32	10.1	SLPI, ALPP, BGLAP, CALCA
5	22-oxacalcitriol32	10.0	ALPP, PTHLH, CASR, BGLAP, VDR
6	tartrate32	10.0	BGLAP, CALCA, PTHLH, ALPP, SLPI
7	glucose32	9.9	PTH, HADHA, CASR, GLA, PTHLH, PRKAR1A
8	pge232	9.8	SNCA, CASR, SLPI, GNAS
9	hydroxyapatite32	9.8	SLPI, CASR, ALPP, BGLAP, PTHLH, GLA
10	lysine32	9.8	CTLA4, TPO, PTHLH, CASR, CXADR, NR1I3
11	hydroxyproline32 18	10.7	SLPI, CALCA, ALPP, BGLAP, PTHLH, PTH
12	neomycin32	9.7	ALPP, F9, CASR, DYT10, PTHLH, NR1I3
13	etidronate32	9.5	SLPI, ALPP, CALCA, BGLAP
14	pyridinoline32	9.5	BGLAP, CALCA, SLPI, IGF1, ALPP, PTHLH
15	phosphorus32	9.5	CALCA, PTH, PTH1R, SLPI, CASR, ALPP
16	24,25-dihydroxyvitamin d332	9.5	VDR, BGLAP, CALCA, DYT10, ALPP
17	alfacalcidol32 9 9	11.5	VDR, BGLAP, SLPI, CALCA
18	deoxypyridinoline32	9.3	IGF1, SLPI, PTH, CALCA, ALPP, BGLAP
19	alendronate32 9 9	11.2	IGF1, CALCA, VDR, BGLAP, PTH, PTHLH
20	aspartate32	9.2	TPO, GLA, F9, VDR, NAGLU, RET
21	thiazide32	9.1	CASR, BGLAP, VDR, INS, CALCA
22	heparin32 9 18 9	12.0	SLPI, PIK3C2A, BGLAP, F9, ALPP, PTHLH
23	ribonucleic acid32	8.9	RET, IGF1, GNAS, CASR, TPO, NR1I3
24	1,25 dihydroxy vitamin d332	8.9	CXADR, NR1I3, PTHLH, ALPP, IGF1, BGLAP
25	cyclic amp32 18	9.7	PTH1R, DYT10, PTHLH, CALCA, CASR, PTH
26	dexamethasone32 42 34 9 9	12.6	BGLAP, VDR, IL2RA, F9, ALPP, GATA3
27	25-hydroxyvitamin d32	8.6	IGF1, BGLAP, VDR, ALPP, CASR, CALCA
28	forskolin32 42 9 9	11.5	GNAS, DYT10, HADHA, CASR, CALCA, PRKAR1A
29	octreotide32 42 9 9	11.4	PTHLH, INS, GNAS, IGF1, FGF23, CALCA
30	hydrocortisone32 9 9	10.3	SLPI, ALPP, INS, IGF1, F9, PTHLH
31	ibmx32	8.3	PTHLH, PTH1R, PTH, DYT10, ALPP, INS
32	calcitriol32 42 9 18 9	12.2	ALPP, IGF1, IL2RA, FGF23, BGLAP, VDR
33	cysteine32	8.1	PRKAR1A, VDR, BGLAP, MTHFR, ALPP, CARS
34	steroid32	8.0	TPO, GNAS, IGF1, IL2RA, NAGLU, PTHLH
35	thyroxine32 18	8.9	BGLAP, PIK3C2A, PTHLH, PTH, TPO, VDR
36	cyclosporin a32 42	8.9	CALCA, NR1I3, SLPI, CTLA4, CASR, ALPP
37	adenylate32	7.7	DYT10, PTHLH, CXADR, SNCA, PRKAR1A, GNAS
38	calcium32 9 18 9	10.5	GATA3, HADHA, SLPI, CARS, ALPP, F9
39	creatinine32	7.4	SPG7, VDR, MTHFR, IL2RA, IGF1, F9
40	thymidine32 18	8.4	NAGLU, PTH1R, SLPI, CXADR, NR1I3, VDR
41	retinoic acid32 42 18	9.1	GATA3, PTHLH, IGF1, SLPI, MTHFR, BGLAP
42	vitamin d32	7.0	SLPI, CXADR, PRKAR1A, NR1I3, CTLA4, CASR
43	cholesterol32 9 18 9	9.7	PIK3C2A, NAGLU, INS, IGF1, F9, ALPP
44	estrogen32	6.6	VDR, MTHFR, INS, ALPP, CASR, F9
45	alanine32	6.2	BGLAP, VDR, MTHFR, PTH1R, INS, HADHA
46	glutamate32	6.2	SNCA, PRKAR1A, CXADR, NR1I3, CTLA4, PTPN22
47	testosterone32 9 18 9	8.9	PTHLH, IGF1, F9, ALPP, CALCA, TPO
48	arginine32	5.8	PIK3C2A, GLA, TPO, PTH, PTPN22, PTHLH
49	tyrosine32	5.6	F9, GNAS, FGF23, NR1I3, SLPI, IGF1
50	serine32	5.2	FGF23, INS, MTHFR, BGLAP, VDR, RET

Cellular components related to hypoparathyroidism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.1	BGLAP, CXADR, SNCA, PTHLH, PTH, GLA

Biological processes related to hypoparathyroidism according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	parathyroid gland development	GO:060017	10.4	GCM2, TBX1, GATA3
2	cAMP metabolic process	GO:046058	10.3	PTHLH, PTH
3	osteoblast development	GO:002076	10.3	BGLAP, PTH1R, PTHLH
4	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	10.3	PTHLH, PTH1R, PTH, CALCA
5	positive regulation of cAMP biosynthetic process	GO:030819	10.1	CALCA, PTH, PTHLH
6	phospholipid translocation	GO:045332	10.0	ATP11C, ATP11A, ATP11B
7	cellular calcium ion homeostasis	GO:006874	10.0	PTH, CASR, VDR, GCM2
8	positive regulation of inositol phosphate biosynthetic process	GO:060732	10.0	SNCA, PTH1R
9	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	9.9	FGF23, VDR
10	skeletal system development	GO:001501	9.4	VDR, PTHLH, PTH1R, PTH, IGF1, BGLAP
11	positive regulation of glycogen biosynthetic process	GO:045725	9.3	PTH, IGF1, INS
12	positive regulation of glucose import	GO:046326	9.2	INS, IGF1, PTH
13	blood coagulation	GO:007596	8.6	GATA3, CXADR, PRKAR1A, GNAS, F9, IGF1

Molecular functions related to hypoparathyroidism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phospholipid-translocating ATPase activity	GO:004012	9.7	ATP11C, ATP11A, ATP11B
2	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO:015662	9.5	ATP11B, ATP11A, ATP11C
3	hormone activity	GO:005179	8.8	INS, IGF1, CALCA, PTH, PTHLH
4	protein binding	GO:005515	5.4	AIRE, PTPN22, SPG7, CTLA4, SNCA, PRKAR1A