Hypophosphatemia malady

Genetics Home Reference: Hereditary hypophosphatemic rickets is a disorder related to low levels of phosphate in the blood (hypophosphatemia). Phosphate is a mineral that is essential for the normal formation of bones and teeth.¹⁷

MalaCards: Hypophosphatemia is related to x-linked hypophosphatemia and hereditary hypophosphatemic rickets. An important gene associated with Hypophosphatemia is FGF23 (fibroblast growth factor 23), and among its related pathways are Folate biosynthesis and NAD metabolism. The drug ergocalciferol and the compounds estrogen and steroid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and prostate, and related mouse phenotypes are integument and homeostasis/metabolism.

Wikipedia: Hypophosphatemia is an electrolyte disturbance in which there is an abnormally low level of phosphate in...⁴⁴ more...

hypophosphatemia 6 7 8 32 43

Diseases related to hypophosphatemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 408)

id	Related Disease	Score	Top Affiliating Genes
1	x-linked hypophosphatemia	35.0	BGLAP, FGF23, GH1, PHEX
2	hereditary hypophosphatemic rickets	30.1	SFRP4, FGF23, MEPE, DMP1, SKA1, SLC34A3
3	hypophosphatemic rickets, autosomal dominant	29.8	SFRP4, FGF23, MEPE, PHEX
4	oncogenic osteomalacia	29.5	SFRP4, FGF23, FGF7, MEPE, CALCA, PTH
5	mccune albright syndrome	28.7	BGLAP, FGF23, ALPP, GNAS, GH1, PTHLH
6	rickets	28.2	VDR, BGLAP, FGF23, ALB, ALPP, CASR
7	jansen's metaphyseal chondrodysplasia	28.1	FGF23, PTH, PTH1R, PTHLH
8	metaphyseal chondrodysplasia	28.1	FGF23, PTH, PTH1R, PTHLH
9	chondrodysplasia	27.9	FGF23, PTH, PTH1R, PTHLH, PHEX
10	familial hypophosphatemia	26.1	KL, VDR, CLCN5, MME, FGF1, FGF23
11	sepsis	25.8	IL18R1, IL6R, AMBP, ALB, CALCA, CRP
12	osteomalacia	25.5	KL, SFRP4, VDR, CLCN5, BGLAP, FGF23
13	nephrolithiasis	25.1	VDR, CLCN5, BGLAP, B2M, MME, FGF23
14	hyperphosphatemia	23.3	KL, SFRP4, VDR, BGLAP, FGF23, ALB
15	osteoporosis	21.9	KL, VDR, BGLAP, B2M, FGF23, MEPE
16	hypercalcemia	21.8	KL, VDR, BGLAP, B2M, FGF2, FGF23
17	hepatocellular carcinoma	20.7	KL, SFRP4, VDR, B2M, MME, FGF1
18	hepatitis	19.9	SFRP4, VDR, BGLAP, B2M, FGF1, FGF2
19	prostatitis	16.7	KL, SFRP4, VDR, BGLAP, B2M, MME
20	carcinoma	16.6	KL, SFRP4, VDR, BGLAP, B2M, MME
21	hereditary hypophosphatemic rickets with hypercalciuria	13.8	FGF23, SLC34A3, SLC34A1
22	hypophosphatemic rickets with hypercalciuria	13.8	FGF23, SLC34A3, SLC34A1
23	vitamin d-dependent rickets type ii	13.8	VDR, CYP27B1
24	clear cell adenoma	13.7	ALPP, PTH
25	arterial calcification of infancy	13.7	FGF23, ENPP1, PHEX
26	parathyroid disorders	13.7	PTH, PTHLH
27	hypophosphatasia	13.7	ALPL, ALPP
28	common bile duct disease	13.7	ALPL, ALPP, ALPPL2
29	tumoral calcinosis, hyperphosphatemic	13.7	KL, FGF23
30	hyperphosphatemic familial tumoral calcinosis	13.7	KL, FGF23
31	spondylosis	13.7	KL, VDR, PTH
32	dentin dysplasia	13.7	MEPE, DMP1, DSPP
33	paget's disease of bone	13.7	BGLAP, B2M, CALCA
34	amyloid tumor	13.7	B2M, CALCA
35	dentin dysplasia, type ii	13.6	DMP1, DSPP
36	testicular neoplasm	13.6	ALPL, ALPP, ALPPL2
37	idiopathic juvenile osteoporosis	13.6	BGLAP, CALCA, GH1
38	hypervitaminosis d	13.6	KL, VDR, FGF23, PTH, CYP27B1
39	ollier disease	13.6	PTH1R, PTHLH
40	dysgerminoma of ovary	13.6	ALPP, PTHLH
41	infectious mononucleosis	13.6	BGLAP, FGF7, ALPL
42	hyperostosis	13.6	KL, BGLAP, FGF23, ALPL, PTH
43	mucinous tubular and spindle renal cell carcinoma	13.6	CLCN5, B2M, SLC12A3
44	root resorption	13.6	CLCN5, CALCA, DMP1, DSPP
45	hypoadrenalism	13.5	CALCA, GH1, PTHLH
46	aminoaciduria	13.5	CLCN5, B2M, OCRL, SLC34A1
47	osteosclerosis	13.5	BGLAP, ALPL, ALPP, ALPPL2, PTH
48	growth retardation with deafness and mental retardation due to igf1 deficiency	13.5	BGLAP, FGF23, GH1, PHEX, G6PC
49	panhypopituitarism	13.5	BGLAP, ALPP, CALCA, GH1
50	syringomyelia	13.5	VDR, GH1, SRF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 ergocalciferol

MalaCards organs/tissues related to hypophosphatemia:

²²

MGI Mouse Phenotypes related to hypophosphatemia:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	INF	PTHLH, CALCA, CASR, GNAS, , FGF7
2	homeostasis/metabolism phenotype	MP:0005376	INF	GGT1, SLC9A3R1, SLC12A3, SLC34A1, SLC34A3, SLPI
3	adipose tissue phenotype	MP:0005375	8.7	PHEX, PTHLH, GH1, GNAS, ALPL, ENPP1
4	hematopoietic system phenotype	MP:0005397	8.6	PTHLH, PTH, CASR, ALPL, ANKH, FGF7
5	renal/urinary system phenotype	MP:0005367	8.2	PHEX, G6PC, OCRL, SLC34A3, SLC34A1, SLC12A3
6	digestive/alimentary phenotype	MP:0005381	8.1	PTH1R, PTHLH, PHEX, SLC34A3, SLC9A3R1, CASR
7	mortality/aging	MP:0010768	7.0	SRF, PHEX, G6PC, OCRL, SLC34A1, SLC9A3R1
8	skeleton phenotype	MP:0005390	6.6	SLC9A3R1, MEPE, FGF23, FGF2, CLCN5, VDR
9	behavior/neurological phenotype	MP:0005386	6.4	CASR, CALCA, PTHLH, SRF, PHEX, G6PC
10	respiratory system phenotype	MP:0005388	INF	SRF, PTH1R, CALCA, ALPL, ANKH,
11	immune system phenotype	MP:0005387	INF	GNAS, PTH, PTHLH, CYP27B1, SRF, PHEX
12	reproductive system phenotype	MP:0005389	INF	SLC34A1, OCRL, GH1, ALPP, ALPL, AMBP
13	craniofacial phenotype	MP:0005382	INF	DSPP, PHEX, DMP1, PTH1R, PTH, GNAS
14	liver/biliary system phenotype	MP:0005370	INF	GH1, , CLCN5
15	other phenotype	MP:0005395	INF	PHEX, CASR, ALPL, ANKH, ENPP1,
16	endocrine/exocrine gland phenotype	MP:0005379	INF	GGT1, PTH, GNAS, , KL
17	limbs/digits/tail phenotype	MP:0005371	INF	PTH, PTHLH, DMP1, PHEX, GGT1, GNAS
18	growth/size phenotype	MP:0005378	INF	PTH1R, PTHLH, CYP27B1, SRF, PHEX, G6PC
19	cardiovascular system phenotype	MP:0005385	INF	GNAS, CALCA, PTH, PTHLH, SRF, CRP
20	nervous system phenotype	MP:0003631	INF	GNAS, CALCA, GH1, PTHLH, PHEX, G6PC

Articles related to hypophosphatemia:

(show top 50)    (show all 67)

id	Title	Authors	Year	Affiliating Genes
1	Early post-transplantation hypophosphatemia is associ ated with elevated FGF-23 levels. (21335460)	Trombetti A.... Rizzoli R.	2011	FGF23
2	Autosomal recessive mental retardation, deafness, ank ylosis, and mild hypophosphatemia associated with a novel ANKH mutation in a co nsanguineous family. (20943778)	Morava E.... Wevers R.A.	2011	ANKH
3	The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia aft er living donor kidney transplantation: a 1-year prospective observational stud y. (21303965)	Kawarazaki H.... Teraoka S.	2011	FGF23
4	Treatment of X-linked hypophosphatemia with calcitrio l and phosphate increases circulating fibroblast growth factor 23 concentration s. (20157195)	Imel E.A.... Econs M.J.	2010	FGF23
5	Circulating levels of soluble klotho and FGF23 in X-l inked hypophosphatemia: circadian variance, effects of treatment, and relations hip to parathyroid status. (20685863)	Carpenter T.O.... Gundberg C.M.	2010	KL, FGF23
6	Long-term clinical outcome and carrier phenotype in a utosomal recessive hypophosphatemia caused by a novel DMP1 mutation. (20499351)	MAokitie O.... JA1ppner H.	2010	DMP1
7	Hypophosphatemia induced by intravenous administratio n of saccharated ferric oxide: another form of FGF23-related hypophosphatemia. (19555782)	Shimizu Y.... Fujita T.	2009	FGF23
8	Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemia. (19387319)	Nafidi O.... D'Amour P.	2009	FGF7, SFRP4, FGF23
9	A rare case of Gitelman's syndrome with hypophosphatemia. (19356345)	Akhtar N.... Hafeez F.	2009	SLC12A3
10	Hypophosphatemia: the common denominator of all ricke ts. (19504043)	Tiosano D.... Hochberg Z.	2009	FGF23
11	Hypophosphatemia with elevations in serum fibroblast growth factor 23 in a child with Jansen's metaphyseal chondrodysplasia. (18854401)	Brown W.W.... McCormick K.L.	2009	PTH1R, PTHLH, FGF23
12	A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3. (18996815)	Page K.... Insogna K.	2008	SLC34A3
13	A novel Phex mutation with defective glycosylation causes hypophosphatemia and rickets in mice. (17710565)	Xiong X.... Gao X.	2008	PHEX
14	Hypophosphatemia, hyperphosphaturia, and bisphosphona te treatment are associated with survival beyond infancy in generalized arteria l calcification of infancy. (20016754)	Rutsch F.... Terkeltaub R.	2008	ENPP1
15	Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. (18172553)	Yuan B.... Drezner M.K.	2008	PHEX
16	Persistent high level of fibroblast growth factor 23 as a cause of post-renal transplant hypophosphatemia. (17891358)	Kawarazaki H.... Fujita T.	2007	FGF23
17	Fever as a cause of hypophosphatemia in patients with malaria. (18159256)	Browner W.... Haber R.	2007	ALB
18	Elevated fibroblast growth factor 23 in a patient with metastatic prostate cancer and hypophosphatemia. (18037105)	Cotant C.L.... Rao P.S.	2007	FGF23
19	Hereditary hypophosphatemias: new genes in the bone-kidney axis. (17635744)	Negri A.L.	2007	DMP1
20	Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'? (16941023)	Bhan I.... Wolf M.	2006	FGF23
21	DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (17033625)	Lorenz-Depiereux B.... Strom T.M.	2006	DMP1, DSPP
22	Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia. (16721588)	Baum M.... Seikaly M.	2006	PHEX
23	Hypophosphatemia: an evidence-based approach to its clinical consequences and management. (16932412)	Amanzadeh J.... Reilly R.F.	2006	SLC34A1
24	Dentinal defects in Hyp mice not caused by hypophosphatemia alone. (16005844)	Ogawa T.... Ooshima T.	2006	PHEX, DSPP
25	Post-renal transplantation hypophosphatemia: a review and novel insights. (16481873)	Ghanekar H.... Sakhaee K.	2006	FGF23
26	Genetic hypophosphatemia: recent advances in physiopathogenic concept (15959411)	Beraud G.... Vantyghem M.C.	2005	SFRP4, FGF23, PHEX
27	Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturia. (15650646)	Salem R.R.... Tray K.	2005	FGF23, PHEX
28	Hereditary hypophosphatemia in adults (16374396)	VAclayoudom-CAcphise F.L.... WAcmeau J.L.	2005	VDR, FGF23, PHEX
29	The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. (15838626)	Yamamoto T.... Ozono K.	2005	FGF23
30	Anthropometric characteristics of X-linked hypophosphatemia. (15057978)	Pronicka E.... Lebiedowski M.	2004	PHEX
31	Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. (15579309)	Sitara D.... Lanske B.	2004	FGF23
32	Adult Still's disease as a manifestation of severe hypophosphatemia. Still's disease--a disturbance of energy metabolism? (12827405)	Deixler E.... Helmke K.	2003	CRP
33	Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12711740)	Jonsson K.B.... Juppner H.	2003	FGF23, PHEX
34	Effect of GH replacement therapy in two male siblings with combined X-linked hypophosphatemia and partial GH deficiency. (14514346)	Schutt S.M.... Hiort O.	2003	GH1, PHEX
35	An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. (12414538)	Carpinelli M.R.... Hilton D.J.	2002	PHEX
36	Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. (12130585)	Shimada T.... Yamashita T.	2002	FGF23
37	Evidence for a PTH-independent humoral mechanism in p ost-transplant hypophosphatemia and phosphaturia. (11532115)	Green J.... Bick T.	2001	SRF
38	Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia. (11498730)	Yamamoto T.... Okada S.	2001	GNAS, SLC34A1
39	X-linked hypophosphatemia in Polish patients. 2. Analysis of clinical features and genotype-phenotype correlation. (14564066)	Popowska E.... Krajewska-Walasek M.	2001	PHEX
40	X-linked hypophosphatemia attributable to pseudoexons of the PHEX gene. (11502821)	Christie P.T.... Thakker R.V.	2001	PHEX
41	PHEX gene and hypophosphatemia. (10620182)	Drezner M.K.	2000	PHEX, SLC34A1
42	Effect of dipyridamole on serum and urinary phosphate in X-linked hypophosphatemia. (11095012)	Seikaly M.G.... Baum M.	2000	BGLAP
43	Mutational analysis of PHEX gene in X-linked hypophosphatemia. (9768674)	Dixon P.H.... Thakker R.V.	1998	PHEX
44	Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. (9063736)	Strom T.M.... Meitinger T.	1997	PHEX
45	The effect of recombinant human growth hormone in children with X-linked hypophosphatemia. (9346990)	Seikaly M.G.... Baum M.	1997	BGLAP
46	cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. (8812412)	Du L.... Ecarot B.	1996	PHEX
47	Treatment of hypophosphatemia in patients receiving s pecialized nutrition support using a graduated dosing scheme: results from a pr ospective clinical trial. (7664552)	Clark C.L.... Brown R.O.	1995	ALB
48	Consequences of the correction of post-transplantation hypophosphatemia on mineral metabolism (8048355)	Ponce P.... Antunes J.	1994	BGLAP
49	Hypophosphatemia and renal tubular dysfunction in alc oholics. Are they related to liver function impairment? (1670633)	Angeli P.... Ruol A.	1991	GGT1
50	Marked hypophosphatemia with decreased serum 1,25-dih ydroxyvitamin D in a patient with hepatocellular carcinoma complicating liver c irrhosis. (1713978)	Mizuno Y.... Kurokawa K.	1991	CYP27B1

Genes related to hypophosphatemia according to GeneCards:

(show all 45)

id	Symbol	Description	Score	GeneCards Section Context
1	FGF23	fibroblast growth factor 23	11.1	Publications, Aliases & Descriptions
2	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.1	Publications, Aliases & Descriptions, Orthologs
3	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.1	Summaries, Publications
4	DMP1	dentin matrix acidic phosphoprotein 1	11.1	Summaries, Publications
5	SLC34A3	solute carrier family 34 (sodium phosphate), member 3	11.0	Publications
6	MEPE	matrix extracellular phosphoglycoprotein	11.0	Publications
7	PTH	parathyroid hormone	11.0	Publications
8	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0	Publications
9	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
10	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
11	SFRP4	secreted frizzled-related protein 4	11.0	Publications
12	EMP1	epithelial membrane protein 1	11.0
13	ALPPL2	alkaline phosphatase, placental-like 2	11.0
14	CLCN5	chloride channel, voltage-sensitive 5	11.0
15	KL	klotho	11.0	Publications
16	G6PC	glucose-6-phosphatase, catalytic subunit	11.0
17	DSPP	dentin sialophosphoprotein	11.0	Publications
18	AMBP	alpha-1-microglobulin/bikunin precursor	11.0
19	ALPL	alkaline phosphatase, liver/bone/kidney	11.0
20	B2M	beta-2-microglobulin	11.0
21	PTHLH	parathyroid hormone-like hormone	11.0	Publications
22	FGF1	fibroblast growth factor 1 (acidic)	11.0
23	GH1	growth hormone 1	11.0	Publications
24	ALPP	alkaline phosphatase, placental	11.0
25	CALCA	calcitonin-related polypeptide alpha	11.0
26	SKA1	spindle and kinetochore associated complex subunit 1	11.0
27	SLC17A2	solute carrier family 17 (sodium phosphate), member 2	11.0
28	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	11.0
29	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
30	FGF7	fibroblast growth factor 7	11.0	Publications
31	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0	Publications
32	PTH1R	parathyroid hormone 1 receptor	11.0	Publications
33	OCRL	oculocerebrorenal syndrome of Lowe	11.0
34	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
35	ANKH	ankylosis, progressive homolog (mouse)	11.0	Publications
36	IL18R1	interleukin 18 receptor 1	11.0	Publications
37	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
38	IL6R	interleukin 6 receptor	11.0	Publications
39	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	11.0
40	GGT1	gamma-glutamyltransferase 1	11.0	Publications
41	GNAS	GNAS complex locus	11.0	Publications
42	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
43	CASR	calcium-sensing receptor	11.0
44	CRP	C-reactive protein, pentraxin-related	11.0	Publications
45	ALB	albumin	11.0	Publications

Pathways related to hypophosphatemia according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	Folate biosynthesis20	10.4	ALPL, ALPP, ALPPL2
2	NAD metabolism41	10.1	ALPPL2, ALPP, ALPL, ENPP1
3	NAD metabolism10	10.1	ALPPL2, ALPP, ALPL, ENPP1
4	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	10.0	CYP27B1, PTH1R, PTH, CALCA, BGLAP, VDR
5	Transcription Role of VDR in regulation of genes involved in osteoporosis10	10.0	CYP27B1, PTH1R, PTH, CALCA, BGLAP, VDR
6	Endocrine and other factor-regulated calcium reabsorption20	9.9	PTH1R, GNAS, VDR, KL
7	Melanoma20	9.8	FGF7, FGF23, FGF2, FGF1
8	Signaling by EGFR38	9.7	FGF7, FGF23, FGF2, FGF1, KL
9	Class B/2 (Secretin family receptors)38	9.7	PTHLH, PTH1R, PTH, CALCA, GNAS
10	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.7	VDR, BGLAP, GNAS, PTH, PTH1R, PTHLH
11	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.7	PTHLH, PTH1R, PTH, GNAS, BGLAP, VDR
12	FGF Pathway36	9.7	FGF7, FGF23, FGF2, FGF1
13	Apoptotic Pathways in Synovial Fibroblasts36	9.6	GH1, FGF7, FGF23, FGF2, FGF1
14	p53 Mediated Apoptosis36	9.6	FGF1, FGF2, FGF23, FGF7, GH1
15	Glioma Invasiveness36	9.6	GH1, FGF7, FGF23, FGF2, FGF1
16	Telomerase Components in Cell Signaling36	9.6	GH1, FGF7, FGF23, FGF2, FGF1
17	Mitochondrial Apoptosis36	9.4	GH1, FGF7, FGF23, FGF2, FGF1
18	PTEN Pathway36	9.4	GH1, MEPE, FGF7, FGF23, FGF2, FGF1
19	NF-KappaB (p50-p65) Pathway36	9.3	GH1, FGF7, FGF23, FGF2, FGF1
20	JNK Pathway36	9.3	IL6R, IL18R1, FGF7, FGF2, FGF1
21	DHA Signaling36	9.2	FGF1, FGF2, FGF23, FGF7, GH1
22	GPCR Pathway36	9.1	SRF, GH1, FGF7, FGF23, FGF2, FGF1
23	Akt Signaling36	9.1	IL6R, IL18R1, FGF7, FGF23, FGF1
24	TGF-Beta Pathway36	9.0	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2
25	MAPK Family Pathway36	9.0	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2
26	JAK-STAT Pathway36	9.0	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2
27	Activation of cAMP-Dependent PKA36	9.0	CLCN5, FGF1, FGF7, GH1, CRP
28	Tec Kinases Signaling36	9.0	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2
29	Antioxidant Action of Vitamin-C36	8.9	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2
30	p38 Signaling36	8.9	GH1, IL6R, IL18R1, FGF7, FGF23, FGF2

Compounds related to hypophosphatemia according to GeneDecks:

(show top 50)    (show all 186)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	INF	CYP27B1, PTHLH, PTH1R, PTH, GH1, CALCA
2	steroid32	INF	GH1, SLPI, G6PC, B2M, , IL6R
3	retinoic acid32 42 18	INF	FGF2, , SLPI, FGF7, CYP27B1, VDR
4	alfacalcidol32 9 9	11.9	VDR, BGLAP, CALCA, CYP27B1, SLPI
5	deoxypyridinoline32	9.9	VDR, BGLAP, IL6R, ALPP, GH1, PTH
6	24,25-dihydroxyvitamin d332	9.9	VDR, BGLAP, CYP27B1, ALPP, CALCA
7	calcium carbonate32	9.9	ALPP, PTHLH, BGLAP, B2M, PTH, CALCA
8	tartrate32	9.7	PTHLH, SLPI, DSPP, ALPP, BGLAP, CALCA
9	22-oxacalcitriol32	9.5	PTHLH, CASR, ALPP, VDR, BGLAP
10	alendronate32 9 9	11.5	CALCA, GH1, PTH, PTHLH, DSPP, SLPI
11	fluoride32	9.4	B2M, CALCA, ALPP, GH1, DSPP, SLPI
12	dmsa32	9.3	CRP, VDR, B2M, AMBP, CALCA
13	pyridinoline32	9.1	SLPI, PTHLH, GH1, CALCA, ALPP, BGLAP
14	25-hydroxyvitamin d32	9.0	SFRP4, VDR, CYP27B1, SLPI, PTHLH, PTH
15	aspartate32	9.0	G6PC, GH1, ALPL, AMBP, FGF7, GGT1
16	hydrocortisone32 9 9	10.8	GH1, FGF1, CALCA, BGLAP, FGF2, SLPI
17	pamidronate32 9 9	10.6	CRP, BGLAP, B2M, ALPP, CASR, CALCA
18	1,25 dihydroxy vitamin d332	8.5	CASR, CALCA, GH1, PTH, PTH1R, PTHLH
19	heparin32 9 18 9	11.4	IL18R1, FGF7, FGF23, FGF1, PTHLH, SRF
20	hydroxyapatite32	8.4	CASR, PTHLH, DMP1, DSPP, SLPI, BGLAP
21	phosphorus32	8.3	GGT1, SLC34A1, SLPI, PHEX, PTH1R, PTH
22	thyroxine32 18	9.3	PTHLH, GGT1, VDR, BGLAP, B2M, PTH
23	cysteine32	7.9	FGF7, AMBP, ALPL, ALB, ALPP, CASR
24	uric acid32 18	8.9	SRF, B2M, AMBP, ALB, CRP, GGT1
25	prednisolone32 9 9	9.7	PTHLH, IL6R, ALB, ALPP, IL18R1, BGLAP
26	cyclic amp32 18	8.2	IL18R1, SLPI, ENPP1, ALPPL2, CASR, CALCA
27	glutamine32	7.0	ENPP1, CRP, VDR, B2M, FGF7, IL18R1
28	creatinine32	6.8	FGF23, IL6R, AMBP, CASR, GH1, PTH
29	calcitriol32 42 9 18 9	10.5	PTH, GH1, CALCA, CASR, ALPP, ALB
30	testosterone32 9 18 9	INF	SLPI, , VDR, BGLAP, B2M, SRF
31	cycloheximide32	INF	B2M, FGF7, IL6R, ALPP, PTH, PTHLH
32	alanine32	INF	PTH1R, GH1, CASR, GNAS, ALPP, ALB
33	dexamethasone32 42 34 9 9	INF	SLPI, GGT1, ALPP, DSPP, G6PC, VDR
34	adenylate32	INF	FGF7, IL18R1, FGF1, , VDR, GNAS
35	leucine32	INF	CASR, GH1, PTH1R, PHEX, G6PC, SLC9A3R1
36	forskolin32 42 9 9	INF	FGF1, SLC9A3R1, SRF, CYP27B1, PTH, PTH1R
37	vegf32	INF	ALPP, KL, BGLAP, B2M, , FGF2
38	serine32	INF	IL18R1, CASR, GH1, PTH1R, PTHLH, SRF
39	vitamin a32 9 18 9	INF	SRF, GGT1, CRP, ALB, AMBP, FGF2
40	sodium32 18	INF	CASR, PTH, PTHLH, SLC17A2, SLC20A2, PHEX
41	pge232	INF	GNAS, SLPI, CYP27B1, CASR, FGF7, FGF2
42	vitamin d32	INF	BGLAP, VDR, SLC34A1, SLPI, DSPP, PHEX
43	cyclosporin a32 42	INF	FGF2, , B2M, BGLAP, VDR, FGF7
44	arginine32	INF	IL18R1, G6PC, BGLAP, , FGF1, FGF23
45	glucose32	INF	PTH, , IL18R1, AMBP, CASR, PTHLH
46	calcium32 9 18 9	INF	SLC12A3, SLC34A1, SLC34A3, ALB, AMBP, ANKH
47	lactate32	INF	DSPP, , GGT1, GH1, SRF, CRP
48	ibmx32	INF	FGF2, GH1, ALPP, FGF1, , CALCA
49	thymidine32 18	INF	FGF2, ALPP, IL6R, IL18R1, FGF7, GNAS
50	hydrogen32 18	INF	SLC9A3R1, SLPI, SRF, CYP27B1, FGF1, PTH1R

Cellular components related to hypophosphatemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	brush border membrane	GO:031526	9.8	SLC9A3R1, SLC34A1, SLC34A3, PTH1R
2	membrane	GO:016020	8.3	EMP1, SLC9A3R1, SLC20A2, SLC12A3, SLC17A2, GNAS
3	extracellular space	GO:005615	6.4	KL, CRP, PTHLH, PTH, GH1, CALCA
4	extracellular region	GO:005576	6.0	GNAS, CALCA, GH1, PTH, PTHLH, CRP
5	integral to plasma membrane	GO:005887	INF	SLC20A2, SLC12A3, SLC34A1, SLC17A2, PHEX, PTH1R
6	plasma membrane	GO:005886	INF	CASR, PTH1R, PHEX, SLC34A3, SLC34A1, SLC12A3

Biological processes related to hypophosphatemia according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	10.5	VDR, FGF23, CYP27B1
2	phosphate ion homeostasis	GO:055062	10.5	SLC34A1, FGF23, SFRP4
3	response to vitamin D	GO:033280	10.3	BGLAP, ALPL, CYP27B1
4	cAMP metabolic process	GO:046058	10.2	PTHLH, PTH
5	osteoblast development	GO:002076	10.2	BGLAP, PTH1R, PTHLH
6	cellular phosphate ion homeostasis	GO:030643	10.2	SLC9A3R1, SLC34A3, ENPP1, FGF23
7	vitamin D catabolic process	GO:042369	10.2	CYP27B1, FGF23
8	biomineral tissue development	GO:031214	10.2	MEPE, ENPP1, DMP1, PHEX, DSPP
9	phosphate-containing compound metabolic process	GO:006796	10.1	SLC17A2, ENPP1, FGF23
10	bone mineralization	GO:030282	10.1	CYP27B1, PTH1R, BGLAP
11	regulation of bone mineralization	GO:030500	10.1	CYP27B1, ANKH, ENPP1, BGLAP
12	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	10.1	PTHLH, PTH1R, PTH, CALCA
13	positive regulation of cAMP biosynthetic process	GO:030819	10.0	CALCA, PTH, PTHLH
14	sodium ion transport	GO:006814	10.0	SLC17A2, SLC34A3, SLC34A1, SLC12A3
15	fibroblast growth factor receptor signaling pathway	GO:008543	9.6	FGF7, FGF23, FGF2, FGF1, KL
16	insulin receptor signaling pathway	GO:008286	9.6	FGF7, FGF23, FGF2, FGF1, KL
17	skeletal system development	GO:001501	9.4	VDR, DSPP, PHEX, PTHLH, PTH1R, PTH
18	negative regulation of cell proliferation	GO:008285	9.1	SLC9A3R1, SRF, CYP27B1, PTHLH, PTH1R, FGF2
19	transmembrane transport	GO:055085	8.3	SLC20A2, SLC12A3, SLC34A1, SLC34A3, G6PC, GNAS
20	positive regulation of keratinocyte differentiation	GO:045618	INF	VDR, , CYP27B1
21	mammary gland branching involved in pregnancy	GO:060745	INF	VDR,

Molecular functions related to hypophosphatemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	GH1, SRF, CRP, SKA1, OCRL, SLPI
2	alkaline phosphatase activity	GO:004035	10.2	ALPL, ALPP, ALPPL2
3	sodium:phosphate symporter activity	GO:005436	9.9	SLC17A2, SLC34A3, SLC20A2
4	hormone activity	GO:005179	9.7	PTHLH, PTH, GH1, CALCA, KL
5	fibroblast growth factor receptor binding	GO:005104	9.6	KL, FGF1, FGF2
6	growth factor activity	GO:008083	9.0	GH1, FGF7, FGF23, FGF2, FGF1