Aliases & Classifications for Hypophosphatemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS
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Hypophosphatemia, Aliases & Descriptions:

Name: Hypophosphatemia 9 11 43 60


External Ids:

Disease Ontology9 DOID:0050336

Summaries for Hypophosphatemia

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Wikipedia:63 Hypophosphatemia is an electrolyte disturbance in which there is an abnormally low level of phosphate in... more...

MalaCards based summary: Hypophosphatemia is related to hypophosphatemic rickets with hypercalciuria and rickets. An important gene associated with Hypophosphatemia is PHEX (phosphate regulating endopeptidase homolog, X-linked), and among its related pathways are Osteoblast Signaling and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs ergocalciferol and potassium phosphate and the compounds hydroxyapatite and paricalcitol have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Related Diseases for Hypophosphatemia

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Diseases related to Hypophosphatemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1hypophosphatemic rickets with hypercalciuria30.8SLC34A3
2rickets30.7PTH, CYP27B1
3hypophosphatemic rickets, autosomal dominant30.7FGF23, PHEX
4nephrocalcinosis30.3PHEX, SLC34A3, SLC34A1
5hyperphosphatemia30.1SLC34A1, PTH, FGF23
6hypercalcemia30.1FGF23, PTH, CYP27B1
7hyperparathyroidism29.8FGF23, PTH, CYP27B1, PHEX
8nephrolithiasis29.7SLC34A3, PTH, FGF23, SLC34A1
9osteoporosis29.7CYP27B1, PTH
10hypophosphatemic rickets, x-linked dominant29.6DMP1, CYP27B1, PHEX, SLC34A1, FGF23, SLC34A3
11primary hyperparathyroidism29.6CYP27B1, PTH, FGF23
12osteomalacia29.4FGF23, SLC34A3, DMP1, CYP27B1, PTH, PHEX
13hepatitis10.5
14anorexia nervosa10.4
15respiratory failure10.3
16leukemia10.3
17hypokalemia10.3
18hypophosphatemic rickets10.3
19oncogenic osteomalacia10.3
20diabetic ketoacidosis10.2
21paraneoplastic syndromes10.2FGF23, PHEX
22marchiafava bignami disease10.2FGF23, PHEX
23hypervitaminosis d10.2FGF23, CYP27B1
24cutaneous-skeletal hypophosphatemia syndrome10.2
25prostate cancer10.1
26panic disorder10.1
27multiple myeloma10.1
28rickets, vitamin d-resistant, type iia10.1
29vitamin d-dependent rickets, type i10.1
30acute liver failure10.1
31burns10.1
32hemolytic anemia10.1
33metabolic acidosis10.1
34myeloma10.1
35pancreatitis10.1
36peritonitis10.1
37prostatitis10.1
38thyrotoxic periodic paralysis10.1
39hereditary hypophosphatemic rickets10.1
40head injury10.1
41dominant hypophosphatemia with nephrolithiasis or osteoporosis10.1
42asthma10.0
43sudden infant death syndrome10.0
44raine syndrome10.0
45fanconi renotubular syndrome 110.0
46myocardial infarction10.0
47metaphyseal chondrodysplasia, murk jansen type10.0
48osteopetrosis, autosomal recessive 410.0
49mccune-albright syndrome, somatic, mosaic10.0
50hepatitis b10.0

Graphical network of the top 20 diseases related to Hypophosphatemia:



Diseases related to hypophosphatemia

Symptoms for Hypophosphatemia

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Drugs & Therapeutics for Hypophosphatemia

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Genetic Tests for Hypophosphatemia

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Anatomical Context for Hypophosphatemia

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MalaCards organs/tissues related to Hypophosphatemia:

31
Bone, Liver, Kidney, Skeletal muscle, Prostate, Brain, Heart, Breast, Myeloid, Bone marrow, Neutrophil

Animal Models for Hypophosphatemia or affiliated genes

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MGI Mouse Phenotypes related to Hypophosphatemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3FGF23, PHEX, PTH, CYP27B1
2MP:00053678.1CYP27B1, PHEX, SLC34A3, SLC34A1, FGF23
3MP:00053717.9DMP1, CYP27B1, PTH, PHEX, FGF23
4MP:00053787.2CYP27B1, PTH, PHEX, SLC34A3, SLC34A1, FGF23
5MP:00053767.0CYP27B1, PTH, PHEX, SLC34A3, SLC34A1, FGF23
6MP:00053906.9FGF23, SLC34A1, SLC34A3, PHEX, PTH, CYP27B1

Publications for Hypophosphatemia

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Articles related to Hypophosphatemia:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Prolonged disturbance of consciousness caused by severe hypophosphatemia: a report of two cases. (25274235)
2014
2
Frequency and long-term outcomes of post-transplant hypophosphatemia after kidney transplantation. (23937423)
2013
3
Severe acute hypophosphatemia during renal replacement therapy adversely affects outcome of critically ill patients with acute kidney injury. (22227698)
2013
4
Calcitonin administration in X-linked hypophosphatemia. (21524226)
2011
5
High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLH. (21597229)
2011
6
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
7
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
8
Hypophosphatemia and neuroleptic malignant syndrome. (17502779)
2007
9
Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'? (16941023)
2006
10
X-linked hypophosphatemia: dental and histologic findings. (16480608)
2006
11
Hypophosphatemia in living liver donors. (16549174)
2006
12
Hypophosphatemia and metabolic acidosis. (15834352)
2005
13
Extra pontine myelinolysis associated with hypophosphatemia. (16045098)
2005
14
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. (15843468)
2005
15
Hypophosphatemia and calcium nephrolithiasis. (15499207)
2004
16
Is hypotonic dysfunctional labor associated with hypophosphatemia? (15167865)
2004
17
Severe hypophosphatemia in a patient with anorexia nervosa during enteral refeeding. (15819381)
2004
18
Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir-induced polyuria and hypophosphatemia. (14675048)
2004
19
Hypophosphatemia after 95 right-lobe living-donor hepatectomies for liver transplantation is not a significant source of morbidity. (14557757)
2003
20
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12890852)
2003
21
Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemia. (12845429)
2003
22
An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. (12414538)
2002
23
FGF23, hypophosphatemia, and rickets: has phosphatonin been found? (11371627)
2001
24
Hypophosphatemia in the emergency department therapeutics. (10919539)
2000
25
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate. (11096051)
2000
26
PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia. (10460513)
1999
27
The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery. (9688005)
1998
28
The effect of recombinant human growth hormone in children with X-linked hypophosphatemia. (9346990)
1997
29
New insights into X-linked hypophosphatemia. (9051349)
1997
30
Anorexia nervosa: refeeding and hypophosphatemia. (8863075)
1996
31
Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock. (7781370)
1995
32
Osteomalacia with hypophosphatemia and hypercalciuria: a possible new variant of osteomalacia. (7608793)
1995
33
Delirium associated with hypophosphatemia in a patient with anorexia nervosa. (8018692)
1994
34
Enthesopathy as the presenting feature of X-linked hypophosphatemia. A case report. (8498190)
1993
35
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
36
Severe unexplained hypophosphatemia. (1733579)
1992
37
Hypocalcemia, but not PTH or hypophosphatemia, induces a rapid increase in 1,25(OH)2D3 levels in rats. (1539647)
1992
38
Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia. (1469097)
1992
39
The effects of hypocalcemia/hypophosphatemia on porcine bone and dental hard tissues in an inherited form of type 1 pseudo-vitamin D deficiency rickets. (1556293)
1992
40
X-linked hypophosphatemia: an appreciation of a classic paper and a survey of progress since 1958. (1851532)
1991
41
Hypophosphatemia in course of chronic obstructive pulmonary disease. Prevalence, mechanisms, and relationships with skeletal muscle phosphorus content. (2108845)
1990
42
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989
43
X-linked hypophosphatemia in adults: prevalence of skeletal radiographic and scintigraphic features. (2539609)
1989
44
Hypophosphatemia in a pediatric patient after major hepatic resection. (2809996)
1989
45
Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia. (3793922)
1987
46
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (3860734)
1985
47
Hypophosphatemia during postoperative glucose infusion. (4090879)
1985
48
Erythrocyte sodium transport in acute hypophosphatemia in man. (6330513)
1984
49
Hypophosphatemia-induced hypercalcemia during acute renal failure. (6671351)
1983
50
Serum parathyroid hormone in X-linked hypophosphatemia. (5315247)
1971

Variations for Hypophosphatemia

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Expression for genes affiliated with Hypophosphatemia

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Search GEO for disease gene expression data for Hypophosphatemia.

Pathways for genes affiliated with Hypophosphatemia

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Pathways related to Hypophosphatemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2FGF23, PTH
29.1PTH, CYP27B1
39.1PTH, CYP27B1

Compounds for genes affiliated with Hypophosphatemia

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Compounds related to Hypophosphatemia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1hydroxyapatite439.5FGF23, DMP1
2paricalcitol43 1210.0PTH, CYP27B1
325-hydroxyvitamin d438.7CYP27B1, PTH, FGF23
4sodium43 249.5SLC34A1, PHEX, PTH
5phosphorus438.1FGF23, CYP27B1, PTH, PHEX, SLC34A1
61,25 dihydroxy vitamin d3438.0FGF23, PTH, SLC34A1, PHEX, CYP27B1
7calcitriol43 59 24 1211.0CYP27B1, PHEX, SLC34A1, FGF23, PTH
8vitamin d437.5CYP27B1, DMP1, PHEX, FGF23, SLC34A1, PTH
9calcium43 49 24 129.8FGF23, SLC34A1, SLC34A3, PHEX, PTH, CYP27B1

GO Terms for genes affiliated with Hypophosphatemia

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Biological processes related to Hypophosphatemia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:00550629.9FGF23, SLC34A1
2positive regulation of vitamin D 24-hydroxylase activityGO:00109809.8CYP27B1, FGF23
3vitamin D catabolic processGO:00423699.8CYP27B1, FGF23
4cellular phosphate ion homeostasisGO:00306439.7FGF23, SLC34A3
5bone mineralizationGO:00302829.6PHEX, CYP27B1
6phosphate ion transportGO:00068179.6SLC34A1, SLC34A3
7ossificationGO:00015039.4DMP1, SLC34A1
8sodium ion transportGO:00068149.4SLC34A1, SLC34A3
9ion transportGO:00068119.4SLC34A1, SLC34A3
10response to lead ionGO:00102889.4SLC34A1, PTH
11response to cadmium ionGO:00466869.3PTH, SLC34A1
12response to vitamin DGO:00332809.3PTH, CYP27B1
13skeletal system developmentGO:00015019.0PTH, PHEX

Molecular functions related to Hypophosphatemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium-dependent phosphate transmembrane transporter activityGO:00153219.4SLC34A1, SLC34A3

Products for genes affiliated with Hypophosphatemia

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Sources for Hypophosphatemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet