MCID: HYP017
MIFTS: 43

Hypophosphatemia malady

Categories: Metabolic diseases

Aliases & Classifications for Hypophosphatemia

Aliases & Descriptions for Hypophosphatemia:

Name: Hypophosphatemia 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050336

Summaries for Hypophosphatemia

MalaCards based summary : Hypophosphatemia is related to cutaneous-skeletal hypophosphatemia syndrome and dominant hypophosphatemia with nephrolithiasis or osteoporosis. An important gene associated with Hypophosphatemia is FGF23 (Fibroblast Growth Factor 23), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Iron and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 71 Hypophosphatemia is an electrolyte disturbance in which there is an abnormally low level of phosphate in... more...

Related Diseases for Hypophosphatemia

Diseases related to Hypophosphatemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 cutaneous-skeletal hypophosphatemia syndrome 12.1
2 dominant hypophosphatemia with nephrolithiasis or osteoporosis 11.8
3 hypophosphatemic rickets, x-linked dominant 11.7
4 hypophosphatemic rickets, autosomal dominant 11.5
5 hereditary hypophosphatemic rickets 11.4
6 nephrolithiasis/osteoporosis, hypophosphatemic, 1 11.3
7 hypophosphatemic rickets, autosomal recessive, 2 11.3
8 hypophosphatemic rickets, ar 11.3
9 hypophosphatemic rickets 11.2
10 panostotic fibrous dysplasia 11.1
11 oncogenic osteomalacia 11.0
12 hypophosphatemic rickets with hypercalciuria 10.9
13 vitamin d-dependent rickets, type i 10.8
14 metaphyseal chondrodysplasia, murk jansen type 10.7
15 lowe syndrome 10.7
16 exostoses, multiple, type 1 10.7
17 autosomal recessive hypophosphatemic rickets 10.7
18 fanconi renotubular syndrome 1 10.7
19 tumoral calcinosis, hyperphosphatemic, familial 10.7
20 nephrolithiasis/osteoporosis, hypophosphatemic, 2 10.7
21 dent disease 10.7
22 wiedemann-steiner syndrome 10.3 FGF23 PHEX
23 ventricular tachycardia, catecholaminergic polymorphic, 3 10.2 DMP1 FGF23
24 keratoderma with woolly hair 10.2 SLC34A1 SLC34A3
25 feigenbaum bergeron richardson syndrome 10.2 FGF23 PHEX
26 acute maxillary sinusitis 10.2 DMP1 FGF23 PHEX
27 epilepsy, idiopathic generalized 14 10.2 BGLAP FGF23
28 familial atrial fibrillation 10.2 ENPP1 FGF23 PHEX
29 deafness, nonsyndromic, modifier 1 10.2 CLCN5 SLC34A3
30 childhood absence epilepsy 10.1 ENPP1 FGF23 PHEX
31 maroteaux stanescu cousin syndrome 10.1 BGLAP FGF23 PHEX
32 orbit lymphoma 10.1 FGF23 PTH
33 juvenile onset parkinson disease 19a 10.1 BGLAP ENPP1
34 rickets 10.1
35 newborn respiratory distress syndrome 10.1 CLCN5 SLC34A1 SLC34A3
36 hepatitis 10.1
37 waardenburg syndrome, type 4b 10.1 PTH SLC34A1
38 hypochondrogenesis 10.1 BGLAP PTH
39 toxicodendron dermatitis 10.1 BGLAP PTH
40 y chromosome detection 10.1 BGLAP PTH
41 anorexia nervosa 10.1
42 hip dysplasia, beukes type 10.1 DMP1 DSPP
43 high-grade dysplasia in patients with barrett esophagus 10.1 BGLAP CLCN5 SLC34A3
44 weill-marchesani syndrome 10.0 FGF23 PTH SLC34A1
45 osteomalacia 10.0
46 adult ependymoblastoma 10.0 BGLAP PTH
47 x-linked hereditary ataxia 10.0 DMP1 ENPP1 FGF23 PHEX
48 adermatoglyphia 10.0 DMP1 DSPP
49 mesenchymal cell neoplasm 10.0 BGLAP PTH
50 interstitial nephritis 10.0 CLCN5 PTH SLC34A1

Graphical network of the top 20 diseases related to Hypophosphatemia:



Diseases related to Hypophosphatemia

Symptoms & Phenotypes for Hypophosphatemia

MGI Mouse Phenotypes related to Hypophosphatemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 CLCN5 DMP1 ENPP1 FGF23 PHEX PTH
2 homeostasis/metabolism MP:0005376 9.91 CLCN5 DMP1 ENPP1 FGF23 PHEX PTH
3 renal/urinary system MP:0005367 9.56 CLCN5 DMP1 ENPP1 FGF23 PHEX SFRP4
4 limbs/digits/tail MP:0005371 9.55 FGF23 PHEX PTH SFRP4 DMP1
5 skeleton MP:0005390 9.32 SLC34A1 SLC34A3 CLCN5 DMP1 ENPP1 FGF23

Drugs & Therapeutics for Hypophosphatemia

Drugs for Hypophosphatemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Early Phase 1 7439-89-6 23925
2 Hematinics Phase 4,Phase 2
3 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
4 Pharmaceutical Solutions Phase 4,Phase 2
5 Ferric Compounds Phase 4,Phase 2
6 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
8 vitamin d Phase 3
9 Cinacalcet Hydrochloride Phase 3,Phase 1
10 Hormone Antagonists Phase 3,Phase 1,Phase 2
11 Hormones Phase 3,Phase 1,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
13 Vitamins Phase 3,Phase 1
14 Calcimimetic Agents Phase 3,Phase 1
15 Mitogens Phase 3,Phase 2,Phase 1
16 Ergocalciferols Phase 3
17 Bone Density Conservation Agents Phase 3,Phase 1,Early Phase 1
18 Calcium, Dietary Phase 3,Phase 1,Phase 2,Early Phase 1
19 Immunoglobulin G Phase 3,Phase 2
20 Immunoglobulins Phase 3,Phase 2
21 Antibodies, Monoclonal Phase 3,Phase 2
22 Antibodies Phase 3,Phase 2
23 Vitamin D2 Nutraceutical Phase 3
24 Calciferol Nutraceutical Phase 3
25
Tenofovir Approved, Investigational Phase 2 147127-20-6 464205
26
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
27
Lenalidomide Approved Phase 2 191732-72-6 216326
28 potassium phosphate Phase 2,Phase 1
29 Dextrans Phase 2
30 Plasma Substitutes Phase 2
31 Anticoagulants Phase 2
32 Protective Agents Phase 2
33 Iron-Dextran Complex Phase 2
34 Blood Substitutes Phase 2
35 Cariostatic Agents Phase 2
36 Nucleic Acid Synthesis Inhibitors Phase 2
37 Angiogenesis Inhibitors Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Anti-Bacterial Agents Phase 2
40 Anti-HIV Agents Phase 2
41 Anti-Infective Agents Phase 2
42 Immunosuppressive Agents Phase 2
43 Anti-Retroviral Agents Phase 2
44 Reverse Transcriptase Inhibitors Phase 2
45 Antiviral Agents Phase 2
46 Phosphorus Supplement Nutraceutical Phase 1, Phase 2
47
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
48
Denosumab Approved Phase 1 615258-40-7
49
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
50
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936

Interventional clinical trials:

(show all 44)
id Name Status NCT ID Phase
1 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
2 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4
3 Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic Rickets Completed NCT00417612 Phase 3
4 Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients Completed NCT00975000 Phase 3
5 Therapeutic Use of Oral Sodium Phosphate (Z-521) in Primary Hypophosphatemic Rickets Completed NCT01237288 Phase 3
6 Efficacy and Safety of KRN23 Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With X Linked Hypophosphatemia (XLH) Recruiting NCT02915705 Phase 3
7 Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02526160 Phase 3
8 Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02537431 Phase 3
9 Hypophosphatemia With Intravenous Ferric Carboxymaltose Versus Iron Dextran in Women With Iron Deficiency Secondary to Heavy Uterine Bleeding Unknown status NCT01307007 Phase 2
10 Investigating a New Way of Giving Medicine to Newborn and Preterm Babies Unknown status NCT01676844 Phase 2
11 An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia Completed NCT01571596 Phase 1, Phase 2
12 A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia Completed NCT01340482 Phase 1, Phase 2
13 Extended Safety Study of Tenofovir Disoproxil Fumarate (TDF) Among HIV-1 Negative Men Completed NCT00131677 Phase 2
14 Cetuximab and Lenalidomide in Head and Neck Completed NCT01133665 Phase 2
15 Growth Hormone Treatment in Children With Hypophosphatemic Rickets Completed NCT02720770 Phase 1, Phase 2
16 Role Of Phosphorus And FGF 23 In Patients With Dent Disease Recruiting NCT02016235 Phase 1, Phase 2
17 Study of KRN23, a Recombinant Fully Human Monoclonal Antibody Against FGF23, in Pediatric Subjects With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02163577 Phase 2
18 Study of the Safety, Pharmacodynamics and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02750618 Phase 2
19 Long-Term Extension Study of KRN23 in Adult Subjects With X-Linked Hypophosphatemia (XLH) Enrolling by invitation NCT02312687 Phase 2
20 Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets Unknown status NCT00473187 Phase 1
21 Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets Unknown status NCT00195936 Phase 1
22 A Study of KRN23 in X-linked Hypophosphatemia Completed NCT00830674 Phase 1
23 Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis Completed NCT01464931 Phase 1
24 A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia Completed NCT02181764 Phase 1
25 Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia. Terminated NCT00622479 Phase 1
26 Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Terminated NCT01748812 Phase 1
27 Using Cinacalcet to Treat the Hypophosphatemia of Early Kidney Transplant Unknown status NCT01011114
28 Perspective Evaluation of Hormones Involved in Serum Phosphate Homeostasis in Patients With Metastatic Renal Cells Carcinoma or Hepatocellular Carcinoma Treated With Sorafenib (SORHORM) Unknown status NCT01230697
29 Calcimimetics in Hypophosphatemic Rickets Unknown status NCT00844740
30 Calcitonin for Treating X-linked Hypophosphatemia Completed NCT01652573
31 FGF-23 Suppressibility by Calcitonin Completed NCT00688077
32 Does Intravenous Iron Therapy Decrease Serum Phosphorous Levels? Completed NCT02420119
33 A Prospective Cohort Study to Describe the Evolution of Persistent Hyperparathyroidism in Kidney Transplant Recipients Completed NCT01163669
34 Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism Completed NCT03027349
35 Effect of Dietary Protein Source on Phosphaturia, PTH and FGF23 in Patients With CKD 3 and 4 Completed NCT00764816
36 Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion. Completed NCT01991574 Early Phase 1
37 Leptin, IGF1 and the Refeeding Index Completed NCT01227850
38 Studying Phosphorus Metabolism Completed NCT00066183
39 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
40 Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients Completed NCT01578824
41 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Recruiting NCT01660308
42 Refeeding Syndrome Among Older Adults Recruiting NCT03141489
43 Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project. Recruiting NCT02233322
44 Hypophosphatemic Rickets in Norway Active, not recruiting NCT01057186

Search NIH Clinical Center for Hypophosphatemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hypophosphatemia

Genetic tests related to Hypophosphatemia:

id Genetic test Affiliating Genes
1 Hypophosphatemia 29

Anatomical Context for Hypophosphatemia

MalaCards organs/tissues related to Hypophosphatemia:

39
Bone, Liver, Kidney, Skeletal Muscle, Prostate, Myeloid, Breast

Publications for Hypophosphatemia

Articles related to Hypophosphatemia:

(show top 50) (show all 596)
id Title Authors Year
1
Corn-Soy-Blend Fortified with Phosphorus to Prevent Refeeding Hypophosphatemia in Undernourished Piglets. ( 28081252 )
2017
2
Hypophosphatemia predicts a failure to recover from adefovir-related renal injury after dose reduction in lamivudine-resistant hepatitis B patients. ( 28079295 )
2017
3
Hypophosphatemia in Users of Cannabis. ( 27692442 )
2017
4
Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia. ( 27884786 )
2017
5
Minimally Invasive Surgical Management of Thoracic Ossification of the Ligamentum Flavum Associated with X-linked Hypophosphatemia. ( 27481600 )
2016
6
Hypophosphatemia in Enterally Fed Patients in the Surgical Intensive Care Unit: Common but Unrelated to Timing of Initiation or Aggressiveness of Nutrition Delivery. ( 27562444 )
2016
7
Hypophosphatemia and recovery of post-hepatectomy liver insufficiency. ( 27275463 )
2016
8
Hypophosphatemia-induced Cardiomyopathy. ( 27650239 )
2016
9
Good's syndrome and hypoparathyroidism combined with hypocalcaemia, hypokalemia, hypomagnesemia, and hypophosphatemia-Case report. ( 26875773 )
2016
10
Two Cases of Hypophosphatemia with Increased Renal Phosphate Excretion in Legionella Pneumonia. ( 27066493 )
2016
11
Hypophosphatemia as a novel etiology of Brugada Phenocopy. ( 26828385 )
2016
12
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice. ( 26762209 )
2016
13
CRISPR/Cas9-mediated mutation of PHEX in rabbit recapitulates human X-linked hypophosphatemia (XLH). ( 27126636 )
2016
14
Hypertension is a characteristic complication of X-linked hypophosphatemia. ( 28025445 )
2016
15
Incidence of hypophosphatemia in advanced cancer patients: a recent report from a single institution. ( 27832387 )
2016
16
Identifying the culprit lesion in tumor induced hypophosphatemia, the solution of a clinical enigma. ( 27709474 )
2016
17
Cutaneous skeletal hypophosphatemia syndrome: clinical spectrum, natural history, and treatment. ( 27497815 )
2016
18
Hypophosphatemia promotes lower rates of muscle ATP synthesis. ( 27338702 )
2016
19
Targeting the ligand in hypophosphatemia. ( 27885013 )
2016
20
Preventing/treating hypophosphatemia by adding phosphate to the dialysate. ( 26689145 )
2016
21
Zoledronate Induced Hypocalcemia and Hypophosphatemia in Osteoporosis: A Cause of Concern. ( 27113952 )
2016
22
Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions. ( 27859495 )
2016
23
Two Case Reports of FGF23-Induced Hypophosphatemia in Childhood Biliary Atresia. ( 27462066 )
2016
24
Health-related quality of life and a cost-utility simulation of adults in the UK with osteogenesis imperfecta, X-linked hypophosphatemia and fibrous dysplasia. ( 27894323 )
2016
25
Poster 282 Functional Gains after Diagnosis of Central Pontine Myelinolysis due to Hypophosphatemia in a Leukemia Patient on an Acute Inpatient Rehabilitation Unit: A Case Report. ( 27673041 )
2016
26
A Case of Hypophosphatemia with Increased Urinary Excretion of Phosphorus Associated with Ibrutinib. ( 27194982 )
2016
27
Tenofovir disoproxil fumarate-associated hypophosphatemia as determined by fractional excretion of filtered phosphate in HIV-infected patients. ( 27613487 )
2016
28
Hypophosphatemia in Critically Ill Children: Risk Factors, Outcome and Mechanism. ( 27392619 )
2016
29
Effect of hypophosphatemia on the withdrawal of mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. ( 27073623 )
2016
30
Quiz Page September 2016: Multiple Myeloma and Hypophosphatemia. ( 27561668 )
2016
31
Hypercalcemia and hypophosphatemia in a 11 years old girl with ovarian tumor. ( 27837927 )
2016
32
An Institutional Change in Continuous Renal Replacement Therapy: Nutrition Support Team Resolves Resultant Severe Hypophosphatemia. ( 27589256 )
2016
33
Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms. ( 26783348 )
2016
34
Choice of High-Dose Intravenous Iron Preparation Determines Hypophosphatemia Risk. ( 27907058 )
2016
35
Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome-induced hypophosphatemia. ( 27679714 )
2016
36
A Case of Severe, Prolonged, Refractory Hypophosphatemia After Zoledronic Acid Administration. ( 26739479 )
2016
37
Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy. ( 27444071 )
2016
38
Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia. ( 27821544 )
2016
39
A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia. ( 27879395 )
2016
40
Clinical outcome of critically ill patients with thrombocytopenia and hypophosphatemia in the early stage of sepsis. ( 27834985 )
2016
41
FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of HMWFGF2 Transgenic Mice. ( 27306296 )
2016
42
Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum. ( 27994603 )
2016
43
Hypophosphatemia, Hypomagnesemia, and Hypokalemia in Pediatric Patients Before and During Exclusive Individualized Parenteral Nutrition. ( 26869613 )
2016
44
Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia. ( 26792657 )
2016
45
A radiological study on intra- and extra-cranial calcifications in adults with X-linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment. ( 26913700 )
2016
46
Incidence and Clinical Outcome of Hypophosphatemia in Pediatric Burn Patients. ( 27380125 )
2016
47
Predictors of hypophosphatemia during refeeding of patients with severe anorexia nervosa. ( 25846384 )
2015
48
Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. ( 26073451 )
2015
49
Prolonged hypophosphatemia following parathyroidectomy in chronic hemodialysis patients. ( 26354572 )
2015
50
Risk factors for refeeding hypophosphatemia in Japanese inpatients with anorexia nervosa. ( 26446402 )
2015

Variations for Hypophosphatemia

Expression for Hypophosphatemia

Search GEO for disease gene expression data for Hypophosphatemia.

Pathways for Hypophosphatemia

Pathways related to Hypophosphatemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.81 BGLAP PTH
2 10.55 BGLAP PTH
3 9.95 BGLAP FGF23 PTH

GO Terms for Hypophosphatemia

Cellular components related to Hypophosphatemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.33 BGLAP SLC34A1 SLC34A3
2 endoplasmic reticulum lumen GO:0005788 9.26 BGLAP DMP1 FGF23 MEPE
3 extracellular region GO:0005576 9.23 BGLAP DMP1 DSPP ENPP1 FGF23 MEPE

Biological processes related to Hypophosphatemia according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.81 DMP1 FGF23 MEPE SLC34A1
2 ossification GO:0001503 9.71 BGLAP DMP1 DSPP SLC34A1
3 skeletal system development GO:0001501 9.65 BGLAP DSPP MEPE PHEX PTH
4 response to vitamin D GO:0033280 9.63 BGLAP PHEX PTH
5 bone mineralization GO:0030282 9.61 BGLAP PHEX
6 regulation of bone mineralization GO:0030500 9.61 BGLAP ENPP1 FGF23
7 response to cadmium ion GO:0046686 9.6 PTH SLC34A1
8 phosphate-containing compound metabolic process GO:0006796 9.59 ENPP1 FGF23
9 phosphate ion transmembrane transport GO:0035435 9.58 SLC34A1 SLC34A3
10 response to lead ion GO:0010288 9.58 PTH SLC34A1
11 negative regulation of bone mineralization GO:0030502 9.57 FGF23 MEPE
12 response to magnesium ion GO:0032026 9.56 FGF23 SLC34A1
13 response to growth hormone GO:0060416 9.55 PHEX SLC34A1
14 phosphate ion transport GO:0006817 9.54 SLC34A1 SLC34A3
15 cellular response to vitamin D GO:0071305 9.54 BGLAP FGF23 PHEX
16 sodium-dependent phosphate transport GO:0044341 9.52 SLC34A1 SLC34A3
17 cellular response to parathyroid hormone stimulus GO:0071374 9.5 FGF23 PHEX SLC34A1
18 response to parathyroid hormone GO:0071107 9.49 PTH SLC34A1
19 response to sodium phosphate GO:1904383 9.48 FGF23 PHEX
20 phosphate ion homeostasis GO:0055062 9.33 FGF23 SFRP4 SLC34A1
21 cellular phosphate ion homeostasis GO:0030643 9.26 ENPP1 FGF23 SLC34A1 SLC34A3
22 biomineral tissue development GO:0031214 9.1 BGLAP DMP1 DSPP ENPP1 MEPE PHEX

Molecular functions related to Hypophosphatemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:phosphate symporter activity GO:0005436 8.96 SLC34A1 SLC34A3
2 sodium-dependent phosphate transmembrane transporter activity GO:0015321 8.62 SLC34A1 SLC34A3

Sources for Hypophosphatemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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