MCID: HYP017
MIFTS: 48

Hypophosphatemia malady

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Summaries for Hypophosphatemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hypophosphatemia is an electrolyte disturbance in which there is an abnormally low level of phosphate in... more...

MalaCards: Hypophosphatemia is related to x-linked hypophosphatemia and rickets. An important gene associated with Hypophosphatemia is PHEX (phosphate regulating endopeptidase homolog, X-linked), and among its related pathways are Osteoblast Signaling and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs ergocalciferol and potassium phosphate and the compounds hydroxyapatite and paricalcitol have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Classifications for Hypophosphatemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS
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Aliases & Descriptions:

hypophosphatemia 8 10 45 62


External Ids:

Disease Ontology8 DOID:0050336

Related Diseases for Hypophosphatemia

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17GeneCards, 18GeneDecks
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Diseases related to Hypophosphatemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1x-linked hypophosphatemia31.1FGF23, SLC34A1, SLC34A3, PHEX, CYP27B1, DMP1
2rickets30.7CYP27B1, PTH
3hypophosphatemic rickets, autosomal dominant30.4FGF23, PHEX
4osteomalacia30.3DMP1, FGF23, SLC34A3, PHEX, PTH, CYP27B1
5nephrocalcinosis30.2PHEX, SLC34A3, SLC34A1
6hyperparathyroidism30.2CYP27B1, PTH, PHEX, FGF23
7hyperphosphatemia30.2PTH, SLC34A1, FGF23
8hypercalcemia30.2FGF23, PTH, CYP27B1
9nephrolithiasis30.1FGF23, SLC34A1, SLC34A3, PTH
10hypophosphatemic rickets with hypercalciuria29.9SLC34A3
11osteoporosis29.7FGF23, PTH, CYP27B1
12primary hyperparathyroidism29.7CYP27B1, PTH, FGF23
13hepatitis10.5
14anorexia nervosa10.4
15respiratory failure10.3
16hypokalemia10.3
17leukemia10.3
18oncogenic osteomalacia10.3
19sepsis10.3
20diabetic ketoacidosis10.2
21mccune albright syndrome10.2
22panic disorder10.1
23metabolic acidosis10.1
24hemolytic anemia10.1
25multiple myeloma10.1
26myeloma10.1
27pancreatitis10.1
28peritonitis10.1
29thyrotoxic periodic paralysis10.1
30head injury10.1
31paraneoplastic syndromes10.0FGF23, PHEX
32hypervitaminosis d10.0FGF23, CYP27B1
33acute liver failure10.0
34burns10.0
35hepatitis b10.0
36sudden infant death syndrome10.0
37renal tubular acidosis10.0
38jansen's metaphyseal chondrodysplasia10.0
39hypokalemic periodic paralysis10.0
40asthma10.0
41diabetes mellitus10.0
42enthesopathy10.0
43hypertension10.0
44myeloid leukemia10.0
45myocardial infarction10.0
46neuropathy10.0
47pneumonia10.0
48prostate cancer10.0
49prostatitis10.0
50panostotic fibrous dysplasia10.0

Graphical network of the top 20 diseases related to Hypophosphatemia:



Diseases related to hypophosphatemia

Symptoms for Hypophosphatemia

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Drugs & Therapeutics for Hypophosphatemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Hypophosphatemia

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Anatomical Context for Hypophosphatemia

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33MalaCards
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MalaCards organs/tissues related to Hypophosphatemia:

33
Bone, Liver, Kidney, Skeletal muscle, Prostate, Breast, Myeloid, Heart, Brain, Bone marrow

Animal Models for Hypophosphatemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypophosphatemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3FGF23, PHEX, PTH, CYP27B1
2MP:00053678.1CYP27B1, PHEX, SLC34A3, SLC34A1, FGF23
3MP:00053717.9DMP1, CYP27B1, PTH, PHEX, FGF23
4MP:00053787.2CYP27B1, PTH, PHEX, SLC34A3, SLC34A1, FGF23
5MP:00053767.0CYP27B1, PTH, PHEX, SLC34A3, SLC34A1, FGF23
6MP:00053906.9FGF23, SLC34A1, SLC34A3, PHEX, PTH, CYP27B1

Publications for Hypophosphatemia

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52PubMed
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Articles related to Hypophosphatemia:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Severe hypophosphatemia induced after first cycle of the ESHAP protocol for Hodgkin's lymphoma: a case report. (23750103)
2013
2
Frequency and long-term outcomes of post-transplant hypophosphatemia after kidney transplantation. (23937423)
2013
3
Severe acute hypophosphatemia during renal replacement therapy adversely affects outcome of critically ill patients with acute kidney injury. (22227698)
2013
4
Calcitonin administration in X-linked hypophosphatemia. (21524226)
2011
5
High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLH. (21597229)
2011
6
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
7
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
8
Hypophosphatemia and neuroleptic malignant syndrome. (17502779)
2007
9
Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'? (16941023)
2006
10
X-linked hypophosphatemia: dental and histologic findings. (16480608)
2006
11
Hypophosphatemia in living liver donors. (16549174)
2006
12
Hypophosphatemia and metabolic acidosis. (15834352)
2005
13
Extra pontine myelinolysis associated with hypophosphatemia. (16045098)
2005
14
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. (15843468)
2005
15
Hypophosphatemia and calcium nephrolithiasis. (15499207)
2004
16
Is hypotonic dysfunctional labor associated with hypophosphatemia? (15167865)
2004
17
Severe hypophosphatemia in a patient with anorexia nervosa during enteral refeeding. (15819381)
2004
18
Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir-induced polyuria and hypophosphatemia. (14675048)
2004
19
Hypophosphatemia after 95 right-lobe living-donor hepatectomies for liver transplantation is not a significant source of morbidity. (14557757)
2003
20
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12890852)
2003
21
Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemia. (12845429)
2003
22
An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. (12414538)
2002
23
FGF23, hypophosphatemia, and rickets: has phosphatonin been found? (11371627)
2001
24
Hypophosphatemia in the emergency department therapeutics. (10919539)
2000
25
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate. (11096051)
2000
26
PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia. (10460513)
1999
27
The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery. (9688005)
1998
28
The effect of recombinant human growth hormone in children with X-linked hypophosphatemia. (9346990)
1997
29
New insights into X-linked hypophosphatemia. (9051349)
1997
30
Anorexia nervosa: refeeding and hypophosphatemia. (8863075)
1996
31
Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock. (7781370)
1995
32
Osteomalacia with hypophosphatemia and hypercalciuria: a possible new variant of osteomalacia. (7608793)
1995
33
Delirium associated with hypophosphatemia in a patient with anorexia nervosa. (8018692)
1994
34
Enthesopathy as the presenting feature of X-linked hypophosphatemia. A case report. (8498190)
1993
35
Hypokalemia, hypophosphatemia, and compartment syndrome of the leg after downhill skiing on moguls. (8157908)
1993
36
Severe unexplained hypophosphatemia. (1733579)
1992
37
Hypocalcemia, but not PTH or hypophosphatemia, induces a rapid increase in 1,25(OH)2D3 levels in rats. (1539647)
1992
38
Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia. (1469097)
1992
39
The effects of hypocalcemia/hypophosphatemia on porcine bone and dental hard tissues in an inherited form of type 1 pseudo-vitamin D deficiency rickets. (1556293)
1992
40
X-linked hypophosphatemia: an appreciation of a classic paper and a survey of progress since 1958. (1851532)
1991
41
Hypophosphatemia in course of chronic obstructive pulmonary disease. Prevalence, mechanisms, and relationships with skeletal muscle phosphorus content. (2108845)
1990
42
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989
43
X-linked hypophosphatemia in adults: prevalence of skeletal radiographic and scintigraphic features. (2539609)
1989
44
Hypophosphatemia in a pediatric patient after major hepatic resection. (2809996)
1989
45
Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia. (3793922)
1987
46
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (3860734)
1985
47
Hypophosphatemia during postoperative glucose infusion. (4090879)
1985
48
Erythrocyte sodium transport in acute hypophosphatemia in man. (6330513)
1984
49
Hypophosphatemia-induced hypercalcemia during acute renal failure. (6671351)
1983
50
Serum parathyroid hormone in X-linked hypophosphatemia. (5315247)
1971

Variations for Hypophosphatemia

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Expression for genes affiliated with Hypophosphatemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypophosphatemia

Search GEO for disease gene expression data for Hypophosphatemia.

Pathways for genes affiliated with Hypophosphatemia

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Hypophosphatemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2FGF23, PTH
29.1PTH, CYP27B1
39.1PTH, CYP27B1

Compounds for genes affiliated with Hypophosphatemia

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45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Hypophosphatemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyapatite459.5FGF23, DMP1
2paricalcitol45 1110.0PTH, CYP27B1
325-hydroxyvitamin d458.7CYP27B1, PTH, FGF23
4sodium45 249.5SLC34A1, PHEX, PTH
5phosphorus458.1FGF23, SLC34A1, PHEX, PTH, CYP27B1
61,25 dihydroxy vitamin d3458.0CYP27B1, PTH, PHEX, SLC34A1, FGF23
7calcitriol45 61 24 1111.0CYP27B1, PTH, PHEX, SLC34A1, FGF23
8vitamin d457.5DMP1, CYP27B1, PTH, PHEX, SLC34A1, FGF23
9calcium45 51 24 119.8DMP1, CYP27B1, PTH, PHEX, SLC34A3, SLC34A1

GO Terms for genes affiliated with Hypophosphatemia

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16Gene Ontology
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Biological processes related to Hypophosphatemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1phosphate ion homeostasisGO:0550629.9FGF23, SLC34A1
2positive regulation of vitamin D 24-hydroxylase activityGO:0109809.8FGF23, CYP27B1
3vitamin D catabolic processGO:0423699.8FGF23, CYP27B1
4cellular phosphate ion homeostasisGO:0306439.7SLC34A3, FGF23
5bone mineralizationGO:0302829.6PHEX, CYP27B1
6phosphate ion transportGO:0068179.6SLC34A1, SLC34A3
7sodium ion transportGO:0068149.4SLC34A3, SLC34A1
8ossificationGO:0015039.4SLC34A1, DMP1
9ion transportGO:0068119.4SLC34A1, SLC34A3
10response to lead ionGO:0102889.4SLC34A1, PTH
11response to cadmium ionGO:0466869.3SLC34A1, PTH
12response to vitamin DGO:0332809.3CYP27B1, PTH
13skeletal system developmentGO:0015019.0PHEX, PTH

Molecular functions related to Hypophosphatemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium-dependent phosphate transmembrane transporter activityGO:0153219.4SLC34A1, SLC34A3

Products for genes affiliated with Hypophosphatemia

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Sources for Hypophosphatemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet