MCID: HYP083
MIFTS: 53

Hypopituitarism malady

Summaries for Hypopituitarism

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  the pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  these hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  symptoms of this condition vary and depend on which hormones are affected.  treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones. last updated: 7/20/2012

MalaCards: Hypopituitarism, also known as pituitary insufficiency nos, is related to diabetes insipidus and growth hormone deficiency. An important gene associated with Hypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Mineralocorticoid biosynthesis and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:64 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Aliases & Classifications for Hypopituitarism

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

hypopituitarism 8 43 10 45 61
pituitary insufficiency nos 8
pituitary insufficiency 43


External Ids:

Disease Ontology8 DOID:9406
MeSH35 D007018
NCIt40 C62591

Related Diseases for Hypopituitarism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypopituitarism family:

familial hypopituitarism

Diseases related to Hypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.7POMC, AQP2, GHRH, PRL, TRH
2growth hormone deficiency30.6CRH, GHRL, GHRH, GH1, PRL, PROP1
3adenoma30.5HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
4septo-optic dysplasia30.5LHX3, HESX1, GH1, PROP1, POU1F1
5sheehan syndrome30.4CRH, PRL, IGF1, POMC
6pituitary apoplexy30.4GNRH1, PRL, TRH, POMC
7thyroiditis30.4TRH, POMC
8acromegaly30.3GNRH1, CRH, GHRL, GHRH, GH1, PRL
9hypoglycemia30.2GNRH1, CRH, GHRL, GHRH, GH1, PRL
10empty sella syndrome30.1POMC, TRH, PRL
11gigantism30.1GH1, PRL, IGF1
12turner syndrome30.1GH1, SHBG, IGF1, CYP21A2
13thyrotoxicosis30.1TRH
14hypoadrenalism30.0POMC, GH1, CRH
15pituitary hypoplasia30.0LHX3, HESX1, SOX3, GHRH, PROP1, POU1F1
16addison's disease30.0CRH, CRHBP, POMC, CYP21A2
17euthyroid sick syndrome30.0TRH
18congenital hypothyroidism29.9CYP21A2, POU1F1
19chromophobe adenoma29.9GH1, PRL
20cushing's syndrome29.9POMC, GH1, CRH
21dwarfism29.9GHRH, GH1, PROP1, IGF1, POU1F1
22holoprosencephaly29.9LHX4, LHX3, HESX1, SOX3, PROP1, POU1F1
23klinefelter's syndrome29.9GNRH1, PRL, PROP1, SHBG, TRH, CYP21A2
24acth deficiency29.9HSD11B1, HESX1, CRH, GH1, PRL, PROP1
25panhypopituitarism29.9LHX4, LHX3, HESX1, GH1, PRL, PROP1
26hyperprolactinemia29.9GNRH1, CRH, GHRH, GH1, PRL, SHBG
27isolated growth hormone deficiency29.7GH1, POU1F1
28graves' disease29.7SHBG, CYP21A2
29mental retardation29.7SOX3, SHBG, AQP2
30amenorrhea29.7GNRH1, CRH, PRL, SHBG, IGF1, TRH
31anorexia nervosa29.7CRH, GHRL, GHRH, GH1, PRL, SHBG
32adrenocortical carcinoma29.7POMC
33atherosclerosis29.7IGF1, SHBG, GHRL, HSD11B1
34short stature29.7LHX4, HESX1, GNRH1, GHRL, GHRH, GH1
35brain injury10.7
36traumatic brain injury10.7
37lymphocytic hypophysitis10.3
38optic nerve hypoplasia10.3
39familial hypopituitarism10.3
40choroideremia hypopituitarism10.2
41anterior pituitary insufficiency, familial10.2
42cavernous sinus thrombosis10.2
43ectodermal dysplasia10.1
44internal carotid agenesis10.1
45germinoma10.1
46granulomatous hypophysitis10.1
47hemorrhagic fever10.1
48hypopituitarism postaxial polydactyly10.1
49head injury10.1
50pallister-hall syndrome10.1

Graphical network of the top 20 diseases related to Hypopituitarism:



Diseases related to hypopituitarism

Clinical Features for Hypopituitarism

Drugs & Therapeutics for Hypopituitarism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypopituitarism

Drug clinical trials:

Search ClinicalTrials for Hypopituitarism

Search NIH Clinical Center for Hypopituitarism

Search CenterWatch for Hypopituitarism

Genetic Tests for Hypopituitarism

Anatomical Context for Hypopituitarism

Animal Models for Hypopituitarism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hypopituitarism

Sources:
51PubMed
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Articles related to Hypopituitarism:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Screening for hypopituitarism in 509 patients with traumatic brain injury or subarachnoid hemorrhage. (23980725)
2014
2
Sudden cardiac death as a result of neglected hypopituitarism. (23825983)
2013
3
Traumatic Brain Injury and Hypopituitarism: A Legal Relationship? (23435162)
2013
4
Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism. (23505376)
2013
5
Low prevalence of hypopituitarism after subarachnoid haemorrhage using confirmatory testing and with BMI-specific GH cut-off levels. (23258271)
2013
6
The identification and measurement of autistic features in children with septo-optic dysplasia, optic nerve hypoplasia and isolated hypopituitarism. (24210356)
2013
7
Consensus document of the Neuroendocrinology area of the Spanish Society of Endocrinology and Nutrition on management of hypopituitarism during transition. (24200635)
2013
8
Deaths among adult patients with hypopituitarism: hypocortisolism during acute stress, and de novo malignant brain tumors contribute to an increased mortality. (23457412)
2013
9
Hyponatremia is the valuable manifestation for initiating diagnosis of hypopituitarism in elderly. (22850090)
2012
10
Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism. (21521324)
2011
11
Giant, thrombosed, sellar-suprasellar internal carotid artery aneurysm with persistent, primitive trigeminal artery causing hypopituitarism. (21234615)
2011
12
Pancytopenia secondary to hypopituitarism may just be due to hypothyroidism alone. (20309687)
2010
13
Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly. (20685856)
2010
14
Acquired factor VIII and von Willebrand factor (aFVIII/VWF) deficiency and hypothyroidism in a case with hypopituitarism. (18550587)
2010
15
Is hypopituitarism predictable after traumatic brain injury? (18059377)
2008
16
Hypopituitarism after radiotherapy for extracranial head and neck cancers in pediatric patients. (19060589)
2008
17
Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. (18493103)
2008
18
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. (18407919)
2008
19
Traumatic brain injury-mediated hypopituitarism. Report of four cases. (17225948)
2007
20
Hypopituitarism following traumatic brain injury (TBI). (17453791)
2007
21
Hormone replacement therapy and vascular risk disorders in adult hypopituitarism. (17283380)
2007
22
Peripartum cardiomyopathy in a woman with hypopituitarism. (16398783)
2006
23
Thyroid hormone in hypopituitarism, Graves' disease, congenital hypothyroidism, and maternal thyroid disease during pregnancy. (16707271)
2006
24
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. (16144947)
2005
25
A patient with hypopituitarism and isochromosome 18q mosaicism. (16272819)
2005
26
Dynamic 13N-ammonia PET: a new imaging method to diagnose hypopituitarism. (15632032)
2005
27
Traumatic brain injury induced hypopituitarism: the need and hope of rehabilitation. (16508707)
2005
28
Hypopituitarism and diabetes insipidus with localized hypertrophic pachymeningitis (Tolosa-Hunt syndrome) associated with Hashimoto thyroiditis. (14722395)
2004
29
Hypopituitarism presenting as a mixed hyperlipidaemia. (15298750)
2004
30
Galactocele in a male infant with congenital hypopituitarism. (15526725)
2004
31
Hypopituitarism, deficiency of factors V and VIII and von Willebrand factor: an uncommon association. (11926206)
2002
32
Medical management of hypopituitarism in patients with pituitary adenomas. (12675508)
2002
33
Hypopituitarism and atherosclerosis. (11680796)
2001
34
Hypopituitarism in langerhans cell histiocytosis: seven cases and literature review. (11686544)
2001
35
Successful pregnancy and delivery after in vitro fertilization and embryo transfer in a patient with primary hypopituitarism. (10785240)
2000
36
Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic dystrophy disease. (11081190)
1999
37
Morning hypoglycemia leading to death in a child with congenital hypopituitarism. (10565473)
1999
38
The molecular basis of hypopituitarism. (9554467)
1998
39
Severe congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation. (9627600)
1998
40
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
41
Hypopituitarism after tuberculous meningitis in childhood. (8460856)
1993
42
A study of anti-pituitary-antibodies in patients with hypopituitarism and their hereditary background]. (1752336)
1991
43
Early hypopituitarism following cavernous sinus thrombosis: total recovery within 1 year. (1660383)
1991
44
Choroideremia and hypopituitarism: an association. (2624260)
1989
45
A case of normotensive primary aldosteronism with hypopituitarism, epilepsy, and medullary sponge kidney. (2609900)
1989
46
Comparison of growth and somatomedin C responses following growth hormone treatment in children with small-for-date short stature, significant idiopathic short stature and hypopituitarism. (6539552)
1984
47
Hypopituitarism after aseptic cavernous sinus thrombosis. (7191077)
1980
48
Dibutyryl cyclic 3':5'-adenosine monphosphate in hypopituitarism and Silver-Russell syndrome. (4365687)
1974
49
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
50
Differential diagnosis of functional hypopituitarism due to malnutrition (idiopathic steatorrhea) and organic pituitary insufficiency in the puerperium; report of two cases. (13378037)
1956

Genetic Variations for Hypopituitarism

Expression for genes affiliated with Hypopituitarism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypopituitarism

Search GEO for disease gene expression data for Hypopituitarism.

Pathways for genes affiliated with Hypopituitarism

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Hypopituitarism

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypopituitarism according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6CRHBP, TRH, HSD11B1
2forskolin45 50 1112.4POU1F1, GHRH, HSD11B1, CRH, POMC
311 deoxycortisol4510.3PRL, CYP21A2, POMC, SHBG, CRH
4fenfluramine29 45 1112.3TRH, CRH, GHRH, POMC, PRL
5oxandrolone45 1111.3GHRL, GH1, IGF1, SHBG
6acth 1-244510.3PRL, POMC, CYP21A2, CRH
7bromocriptine29 45 1112.3POU1F1, TRH, SHBG, PRL, GHRH, GNRH1
8cortisone45 2411.3HSD11B1, POMC, CRH, CYP21A2, GH1, IGF1
9ghrp4510.3GHRL, IGF1, PRL, TRH, GHRH, GH1
10leuprolide acetate4510.2GNRH1, GH1, PRL, CYP21A2, IGF1, SHBG
11norepinephrine45 11 2412.2CYP21A2, POMC, TRH, GHRH, GNRH1, PRL
12pyridostigmine45 1111.2CRH, GHRL, GHRH, TRH, IGF1, PRL
13spironolactone50 45 60 29 1114.2POMC, CYP21A2, CRH, GNRH1, SHBG
14naltrexone45 50 29 1113.2GNRH1, CRH, POMC, IGF1, PRL, GH1
1517-hydroxyprogesterone45 2411.2SHBG, CYP21A2, POMC, PRL, GNRH1, CRH
16hexarelin45 2911.2POMC, IGF1, PRL, GH1, GHRH, GHRL
17clonidine45 29 1112.2GHRH, TRH, POMC, GH1, PRL, IGF1
18clomiphene citrate4510.2CYP21A2, IGF1, SHBG, PRL, GH1, CRH
19opiate4510.2CRH, GNRH1, GH1, PRL, GHRH, POMC
20metformin45 50 1112.2IGF1, GNRH1, GH1, SHBG, POMC, GHRL
21allopregnanolone4510.1POMC, GNRH1, CRH, SHBG
22corticosterone45 60 2412.1CRH, PRL, POMC, CYP21A2, GHRL, HSD11B1
2311beta-hydroxysteroid4510.1POMC, GH1, CRH, HSD11B1, CYP21A2
24naloxone45 50 29 1113.1POMC, TRH, PRL, GH1, GNRH1, GHRH
25dopamine45 29 11 2413.1IGF1, GNRH1, CRH, TRH, SHBG, GHRL
26mifepristone45 60 29 1113.0HSD11B1, GNRH1, POMC, SHBG, PRL, CRH
27dhea4510.0CYP21A2, POMC, IGF1, SHBG, GH1, PRL
28androstenedione45 2411.0CYP21A2, CRH, GNRH1, HSD11B1, POMC, IGF1
29triiodothyronine4510.0GHRL, GHRH, GH1, PRL, SHBG, IGF1
30dehydroepiandrosterone sulfate4510.0CYP21A2, POMC, IGF1, GNRH1, CRH, GHRL
31octreotide45 60 29 1113.0POMC, TRH, GNRH1, CRH, GHRL, GHRH
32epinephrine45 11 2412.0CRH, GNRH1, AQP2, POMC, CYP21A2, GHRL
33alanine459.9GH1, SHBG, CRH, POU1F1, POMC, AQP2
34cocaine45 1110.9GNRH1, POMC, TRH, PRL, GHRL, CRH
35adenylate459.9POMC, SHBG, GHRH, GNRH1, CRH, GH1
36ribonucleic acid459.8IGF1, POU1F1, POMC, CYP21A2, PRL, GH1
37thyroxine45 2410.8CRH, GHRL, GHRH, GH1, PRL, SHBG
38vitamin d459.8CRH, GHRH, SHBG, IGF1, POU1F1, GHRL
39dihydrotestosterone45 29 11 2412.8IGF1, PRL, GH1, GNRH1, CYP21A2, SHBG
40hydrocortisone45 2 60 1112.7POMC, CYP21A2, AQP2, TRH, IGF1, HSD11B1
41steroid459.7POU1F1, CYP21A2, AQP2, IGF1, POMC, CRH
42glucose459.7TRH, CYP21A2, HSD11B1, GHRL, GHRH, PRL
43testosterone45 60 11 2412.7HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
44estradiol45 11 2411.6HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
45arginine459.6POMC, CYP21A2, AQP2, PRL, SHBG, POU1F1
46gnrh459.6CYP21A2, POMC, TRH, IGF1, LHX3, HESX1
47progesterone45 60 29 11 2413.6IGF1, TRH, POU1F1, POMC, CYP21A2, AQP2
48acth459.5HSD11B1, CRH, GNRH1, HESX1, CYP21A2, POMC
49dexamethasone45 50 29 1112.4HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
50creatinine459.4SHBG, IGF1, GH1, AQP2, GHRL, POMC

GO Terms for genes affiliated with Hypopituitarism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3POMC, GHRL
2varicosityGO:04319610.0CRHBP, CRH
3secretory granuleGO:03014110.0CRHBP, PRL, TRH, POMC
4extracellular spaceGO:0056159.7GNRH1, CRH, CRHBP, GHRL, GHRH, GH1
5extracellular regionGO:0055769.6POMC, GNRH1, CRH, GHRL, GHRH, GH1

Biological processes related to Hypopituitarism according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.6LHX4, LHX3
2cellular response to cocaineGO:07131410.6CRH, CRHBP
3positive regulation of cortisol secretionGO:05146410.6CRH, GHRL
4negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.6CRH, GHRL
5positive regulation of growth hormone secretionGO:06012410.5GHRL, GHRH
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.5GHRH, GH1, IGF1
7positive regulation of corticotropin secretionGO:05146110.5GHRL, CRH
8glucocorticoid biosynthetic processGO:00670410.5CYP21A2, CRH, HSD11B1
9ovulation cycleGO:04269810.5GNRH1, PRL
10growth hormone secretionGO:03025210.5GHRL, GHRH
11positive regulation of multicellular organism growthGO:04001810.5GHRL, GHRH, GH1, POU1F1
12parturitionGO:00756710.5CRH, PRL
13hormone-mediated signaling pathwayGO:00975510.4TRH, GHRL, CRHBP
14response to ethanolGO:04547110.4GNRH1, CRH, PRL, TRH
15female pregnancyGO:00756510.3AQP2, PRL, CRHBP, CRH, GNRH1
16synaptic transmission, dopaminergicGO:00196310.3CRHBP, CRH
17positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
18regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.3CRHBP, CRH
19negative regulation of apoptotic processGO:04306610.2PROP1, GHRL, GNRH1, LHX3, LHX4
20cell-cell signalingGO:00726710.2POMC, TRH, GHRH, GNRH1
21organ morphogenesisGO:00988710.2LHX4, LHX3, SOX3
22hypothalamus developmentGO:02185410.0CRH, SOX3
23signal transductionGO:00716510.0GNRH1, CRH, CRHBP, IGF1, TRH, POMC

Molecular functions related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3PRL, GH1
2growth hormone-releasing hormone activityGO:01660810.0GHRH, GHRL
3hormone activityGO:0051799.8POMC, GNRH1, CRH, GH1, PRL, IGF1

Products for genes affiliated with Hypopituitarism

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Sources for Hypopituitarism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet