MCID: HYP083
MIFTS: 52

Hypopituitarism malady

Genetic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Hypopituitarism

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  the pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  these hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  symptoms of this condition vary and depend on which hormones are affected.  treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones. last updated: 7/20/2012

MalaCards: Hypopituitarism, also known as pituitary insufficiency nos, is related to adenoma and growth hormone deficiency. An important gene associated with Hypopituitarism is PROP1 (PROP paired-like homeobox 1). The compounds bromocriptine and steroid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and thyroid, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Wikipedia:65 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Aliases & Classifications for Hypopituitarism

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypopituitarism 8 43 10 45 62
pituitary insufficiency nos 8
pituitary insufficiency 43


External Ids:

Disease Ontology8 DOID:9406
MeSH35 D007018
NCIt40 C62591

Related Diseases for Hypopituitarism

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypopituitarism family:

Familial Hypopituitarism

Diseases related to Hypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5GHRH, PROP1, POU1F1
2growth hormone deficiency30.4SOX3, POU1F1, HESX1, PROP1, GHRH
3septo-optic dysplasia30.4LHX3, POU1F1, HESX1, PROP1
4pituitary adenoma30.4GHRH, PROP1, POU1F1
5obesity30.3HESX1, PROP1, GHRH
6hypothyroidism30.3GHRH, PROP1, HESX1, POU1F1, LHX3
7empty sella syndrome30.0LHX3, POU1F1, PROP1
8hypogonadism30.0PROP1, POU1F1
9acth deficiency29.9POU1F1, HESX1, PROP1
10dwarfism29.9GHRH, PROP1, POU1F1
11panhypopituitarism29.7LHX3, PROP1, HESX1, POU1F1, LHX4
12pituitary hypoplasia29.7LHX3, LHX4, SOX3, GHRH, PROP1, HESX1
13short stature29.5LHX4, POU1F1, HESX1, PROP1, GHRH
14holoprosencephaly29.4PROP1, HESX1, POU1F1, SOX3, LHX4, LHX3
15brain injury10.7
16traumatic brain injury10.7
17diabetes insipidus10.5
18aneurysm10.4
19thyroiditis10.4
20lymphocytic hypophysitis10.3
21optic nerve hypoplasia10.3
22pituitary apoplexy10.3
23acromegaly10.2
24familial hypopituitarism10.2
25anterior pituitary insufficiency, familial10.2
26choroideremia hypopituitarism10.2
27sheehan syndrome10.2
28hypoglycemia10.2
29cavernous sinus thrombosis10.2
30endotheliitis10.2
31diabetes mellitus10.1
32ectodermal dysplasia10.1
33b-cell lymphomas10.1
34germinoma10.1
35gigantism10.1
36granulomatous hypophysitis10.1
37hemorrhagic fever10.1
38head injury10.1
39mental retardation, x-linked, with isolated growth hormone deficiency10.1
40pallister-hall syndrome10.1
41cerebritis10.1
42craniopharyngioma10.1
43functioning pituitary adenoma10.1
44hemorrhagic fever with renal syndrome10.1
45hydrocephalus10.1
46meningitis10.1
47thyrotoxicosis10.1
48arthrogryposis, distal, with hypopituitarism, mental retardation, and facial anomalies10.1
49corpus callosum dysgenesis hypopituitarism10.1
50hypoadrenalism10.1

Graphical network of the top 20 diseases related to Hypopituitarism:



Diseases related to hypopituitarism

Symptoms for Hypopituitarism

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Drugs & Therapeutics for Hypopituitarism

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hypopituitarism

Search NIH Clinical Center for Hypopituitarism

Genetic Tests for Hypopituitarism

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Anatomical Context for Hypopituitarism

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33MalaCards
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MalaCards organs/tissues related to Hypopituitarism:

33
Pituitary, Brain, Thyroid, Testes, Bone, Endothelial, Hypothalamus, B cells, Liver, Kidney, Lung, Heart, Uterus, Colon

Animal Models for Hypopituitarism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hypopituitarism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7HESX1, POU1F1, LHX3
2MP:00053828.2LHX3, SOX3, POU1F1, HESX1
3MP:00053897.8LHX3, SOX3, POU1F1, PROP1, GHRH
4MP:00053787.5LHX3, SOX3, POU1F1, PROP1, GHRH
5MP:00107687.3LHX3, LHX4, SOX3, POU1F1, HESX1, PROP1
6MP:00053767.3LHX3, LHX4, SOX3, POU1F1, PROP1, GHRH
7MP:00053796.9GHRH, LHX3, LHX4, SOX3, POU1F1, HESX1
8MP:00036316.9LHX3, LHX4, SOX3, POU1F1, HESX1, PROP1

Publications for Hypopituitarism

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Sources:
52PubMed
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Articles related to Hypopituitarism:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Sudden cardiac death as a result of neglected hypopituitarism. (23825983)
2013
2
Traumatic Brain Injury and Hypopituitarism: A Legal Relationship? (23435162)
2013
3
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
4
Measurement of oxidative stress and endothelial dysfunction in patients with hypopituitarism and severe deficiency adult growth hormone deficiency. (22228310)
2012
5
Hypopituitarism due to primary empty sella and uncommon muscular symptoms. (21258802)
2012
6
Sturge-Weber syndrome: presentation with partial hypopituitarism. (23155711)
2012
7
Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. (22246489)
2012
8
Pathophysiology of hypopituitarism in the setting of brain injury. (18481181)
2012
9
Anterior hypopituitarism is rare and autoimmune disease is common in adults with idiopathic central diabetes insipidus. (22026638)
2012
10
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
11
Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism. (21521324)
2011
12
Hypopituitarism as unusual sequelae to central nervous system tuberculosis. (22029037)
2011
13
Increased transactivation associated with SOX3 polyalanine tract deletion in a patient with hypopituitarism. (21289259)
2011
14
A giant aneurysm of internal carotid artery causing hypopituitarism. (20636831)
2010
15
Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. (20174891)
2010
16
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
17
Prevalence, natural history and consequences of posttraumatic hypopituitarism: a case for endocrine surveillance. (20158347)
2010
18
Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up. (20501686)
2010
19
Hypopituitarism following traumatic brain injury: prevalence is affected by the use of different dynamic tests and different normal values. (19783619)
2010
20
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
21
Congenital hypopituitarism: clinico-radiological correlation. (20020580)
2009
22
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
23
Female sexual dysfunction in hypopituitarism. (17765514)
2007
24
Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation. (17127446)
2007
25
Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated? (17551481)
2007
26
Untreated hypopituitarism due to absence of the pituitary stalk with normal adult height: report of two cases. (16622308)
2006
27
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. (16144947)
2005
28
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
29
Primary hypothyroidism associated with empty sella turcica and hypopituitarism]. (16296587)
2005
30
Neonatal hypopituitarism presenting with poor feeding, hypoglycemia and prolonged unconjugated hyperbilirubinemia. (15512725)
2004
31
Optic nerve aplasia in an infant with congenital hypopituitarism and posterior pituitary ectopia. (14718312)
2004
32
The spectrum of hypopituitarism caused by PROP1 mutations. (12464226)
2002
33
Postpartum thyroiditis or hypopituitarism? (12240872)
2002
34
Survival with hypopituitarism from congenital syphilis. (11927736)
2002
35
Spontaneous thrombosis of a giant internal carotid aneurysm in a patient who presented with hypopituitarism. (12617242)
2002
36
Premature mortality and hypopituitarism. (11430385)
2001
37
The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months. (11701703)
2001
38
Rheumatoid factor positive hypertrophic cranial pachymeningitis in association with hypopituitarism and multiple cranial nerve palsies. (11579967)
2001
39
Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism. (10931083)
2000
40
MR imaging in children with ectopic pituitary gland and anterior hypopituitarism. (10734341)
1999
41
Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic dystrophy disease. (11081190)
1999
42
Hydrocortisone replacement therapy in children and adolescents with hypopituitarism. (9302370)
1997
43
Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. (8881449)
1996
44
Peripartum hypopituitarism and lymphocytic hypophysitis. (7648244)
1995
45
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
46
Comparison of growth and somatomedin C responses following growth hormone treatment in children with small-for-date short stature, significant idiopathic short stature and hypopituitarism. (6539552)
1984
47
Hypothalamic hypopituitarism. A case of panhypopituitarism with TSH and LH deficiency of hypothalamic origin. (4196985)
1973
48
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
49
Essential hypernatremia, absence of thirst, hypopituitarism, and hypothalamic destruction due to a dysgerminoma. (4679411)
1972
50
An endobronchial chondroma in a cachectic psychotic with hypopituitarism. (13253916)
1955

Variations for Hypopituitarism

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Expression for genes affiliated with Hypopituitarism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypopituitarism

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Pathways for genes affiliated with Hypopituitarism

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Compounds for genes affiliated with Hypopituitarism

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45Novoseek, 29IUPHAR, 11DrugBank
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Compounds related to Hypopituitarism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromocriptine45 29 1110.8GHRH, POU1F1
2steroid458.8GHRH, PROP1, POU1F1
3gnrh458.5LHX3, HESX1, PROP1, GHRH
4acth458.3GHRH, PROP1, HESX1, POU1F1

GO Terms for genes affiliated with Hypopituitarism

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16Gene Ontology
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Cellular components related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.6PROP1, LHX3
2nucleusGO:0056347.0PROP1, HESX1, POU1F1, SOX3, LHX4, LHX3

Biological processes related to Hypopituitarism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1pituitary gland developmentGO:0219839.6SOX3, LHX3
2medial motor column neuron differentiationGO:0215269.5LHX4, LHX3
3motor neuron axon guidanceGO:0080459.5LHX3, LHX4
4central nervous system developmentGO:0074179.3PROP1, SOX3
5placenta developmentGO:0018909.3LHX4, LHX3
6positive regulation of multicellular organism growthGO:0400189.2POU1F1, GHRH
7organ morphogenesisGO:0098879.1SOX3, LHX4, LHX3
8negative regulation of apoptotic processGO:0430668.9LHX3, LHX4, PROP1
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.8PROP1, POU1F1, LHX3

Molecular functions related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.7PROP1, HESX1
2chromatin bindingGO:0036828.6PROP1, HESX1, POU1F1
3sequence-specific DNA bindingGO:0435658.0LHX3, LHX4, POU1F1, HESX1
4sequence-specific DNA binding transcription factor activityGO:0037007.7PROP1, HESX1, POU1F1, LHX4, LHX3

Products for genes affiliated with Hypopituitarism

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Sources for Hypopituitarism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet