MCID: HYP083
MIFTS: 58

Hypopituitarism malady

Summaries for Hypopituitarism

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  the pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  these hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  symptoms of this condition vary and depend on which hormones are affected.  treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones. last updated: 7/20/2012

MalaCards: Hypopituitarism, also known as pituitary insufficiency nos, is related to diabetes insipidus and thyroiditis. An important gene associated with Hypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Mineralocorticoid biosynthesis and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and thyroid, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:63 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Aliases & Classifications for Hypopituitarism

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

hypopituitarism 8 42 10 44 60
pituitary insufficiency nos 8
pituitary insufficiency 42


External Ids:

Disease Ontology8 DOID:9406
MeSH34 D007018
NCIt39 C62591

Related Diseases for Hypopituitarism

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17GeneCards, 18GeneDecks
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Diseases in the Hypopituitarism family:

Familial Hypopituitarism

Diseases related to Hypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.7POMC, AQP2, GHRH, PRL, TRH
2thyroiditis30.5TRH, POMC
3adenoma30.5HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
4pituitary adenoma30.4PRL, PROP1, IGF1, TRH, POU1F1, POMC
5hypothyroidism30.4GHRL, SHBG, TRH
6pituitary apoplexy30.4GNRH1, PRL, TRH, POMC
7acromegaly30.3GH1, PRL, IGF1
8obesity30.3HSD11B1, HESX1, CRH, GHRL, GHRH, GH1
9septo-optic dysplasia30.2LHX3, HESX1, GH1, PROP1, POU1F1
10sheehan syndrome30.2CRH, PRL, IGF1, POMC
11hypoglycemia30.2GNRH1, CRH, GHRL, GHRH, GH1, PRL
12diabetes mellitus30.1HSD11B1, GHRL, GH1, SHBG, IGF1, POMC
13empty sella syndrome30.1POMC, TRH, PRL
14thyrotoxicosis30.0TRH
15congenital hypothyroidism30.0CYP21A2, POU1F1
16pituitary hypoplasia30.0LHX3, HESX1, SOX3, GHRH, PROP1, POU1F1
17craniopharyngioma30.0GH1, PRL, PROP1, IGF1, TRH, POMC
18hypogonadism30.0POMC, POU1F1, TRH, IGF1, SHBG, PROP1
19addison's disease29.9CRH, CRHBP, POMC, CYP21A2
20euthyroid sick syndrome29.9TRH
21chromophobe adenoma29.9GH1, PRL
22cushing's syndrome29.9POMC, GH1, CRH
23hypothalamic disease29.9PRL, GH1, CRH, GNRH1
24hypertension29.9POMC, IGF1, CRH, HSD11B1
25dwarfism29.9GHRH, GH1, PROP1, IGF1, POU1F1
26holoprosencephaly29.9LHX4, LHX3, HESX1, SOX3, PROP1, POU1F1
27turner syndrome29.9GH1, SHBG, IGF1, CYP21A2
28klinefelter's syndrome29.9GNRH1, PRL, PROP1, SHBG, TRH, CYP21A2
29panhypopituitarism29.9LHX4, LHX3, HESX1, GH1, PRL, PROP1
30hyperprolactinemia29.9GNRH1, CRH, GHRH, GH1, PRL, SHBG
31goiter29.7TRH
32dementia29.7TRH
33leiomyoma29.7GNRH1
34graves' disease29.7SHBG, CYP21A2
35pituitary cancer29.7PRL, POMC
36hyperthyroidism29.7GHRL, GHRH, GH1, PRL, SHBG, IGF1
37amenorrhea29.7GNRH1, CRH, PRL, SHBG, IGF1, TRH
38anorexia nervosa29.7CRH, GHRL, GHRH, GH1, PRL, SHBG
39adrenocortical carcinoma29.6POMC
40atherosclerosis29.6IGF1, SHBG, GHRL, HSD11B1
41anterior pituitary insufficiency, familial10.2
42cavernous sinus thrombosis10.1
43choroideremia hypopituitarism10.1
44mental retardation, x-linked, with isolated growth hormone deficiency10.1
45cerebritis10.0
46pallister-hall syndrome10.0
47functioning pituitary adenoma10.0
48hemorrhagic fever with renal syndrome10.0
49hydrocephalus10.0
50meningitis10.0

Graphical network of the top 20 diseases related to Hypopituitarism:



Diseases related to hypopituitarism

Clinical Features for Hypopituitarism

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Drugs & Therapeutics for Hypopituitarism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hypopituitarism

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Anatomical Context for Hypopituitarism

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32MalaCards
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MalaCards organs/tissues related to Hypopituitarism:

32
Pituitary, Brain, Thyroid, Testes, Bone, Endothelial, B cells, Hypothalamus, Liver, Lung, Kidney, Heart, Uterus, Colon

Animal Models for Hypopituitarism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2POU1F1, PROP1, GHRH, SOX3, HESX1, LHX3
2MP:000537510.0POMC, IGF1, GH1, GHRL, HSD11B1
3MP:00053899.6LHX3, GNRH1, SOX3, GHRH, GH1, PRL
4MP:00053709.6HSD11B1, GNRH1, GHRH, GH1, PRL, POMC
5MP:00053869.6HSD11B1, SOX3, CRH, CRHBP, GHRL, PRL
6MP:00036319.3SOX3, GNRH1, HESX1, LHX3, LHX4, HSD11B1
7MP:00053789.3CRHBP, CRH, SOX3, GNRH1, LHX3, HSD11B1
8MP:00053769.2GHRL, CRH, SOX3, GNRH1, LHX3, LHX4

Publications for Hypopituitarism

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50PubMed
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Articles related to Hypopituitarism:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Rapidly evolving hypopituitarism in a boy with multiple autoimmune disorders. (23586429)
2013
2
Sertraline alleviated osmophobia caused by partial hypopituitarism with isolated ACTH deficiency. (22902256)
2013
3
Small-cell lung cancer presenting as hypopituitarism. (23158214)
2013
4
Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia. (23386640)
2013
5
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
6
Measurement of oxidative stress and endothelial dysfunction in patients with hypopituitarism and severe deficiency adult growth hormone deficiency. (22228310)
2012
7
A lifelong smoker with hypopituitarism: rethinking the hypothesis of a tumor in the hypophysis. (22577392)
2012
8
Hypopituitarism following poisonous viperbite. (23029848)
2012
9
Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells. (22855340)
2012
10
Bone and hypopituitarism: not only a mass issue. (22744379)
2012
11
A patient with a skull defect, dysmorphic features, hypopituitarism, and abnormal cortical development. (22192933)
2012
12
Clinical spectrum of hypopituitarism in India: A single center experience. (23087868)
2012
13
Hypopituitarism in a HIV affected patient. (21922454)
2011
14
Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up. (20501686)
2010
15
Chronic hypopituitarism after traumatic brain injury: risk assessment and relationship to outcome. (18580806)
2008
16
Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study. (18381581)
2008
17
A case of hypopituitarism due to inflammatory myofibroblastic tumor of the sella turnica. (18379128)
2008
18
Hypopituitarism in the elderly: multifaceted clinical and biochemical presentation. (20021371)
2008
19
Hypopituitarism caused by bilateral internal carotid artery aneurysms with a carotid-cavernous fistula. (18421209)
2008
20
Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated? (17551481)
2007
21
Array comparative genomic hybridisation analysis of boys with X-linked hypopituitarism identifies a 3.9 Mb duplicated critical region at Xq27 containing SOX3. (17400794)
2007
22
Diffuse malignant lymphoma type B with optic chiasm infiltration, visual disturbances, hypopituitarism, hyperprolactinaemia and diabetes insipidus. Case report and literature review. (17253438)
2006
23
Hypopituitarism: a sequela of severe hypoxic encephalopathy. (16877232)
2006
24
Risk factors of cardiovascular disease in GH-deficient adults with hypopituitarism: a preliminary report. (16449951)
2006
25
Visual vignette. Hypopituitarism with central diabetes insipidus attributable to traumatic brain injury. (16524870)
2006
26
Hypopituitarism findings in patients with primary brain tumors 1 year after neurosurgical treatment: preliminary report. (16840829)
2006
27
Expert meeting: hypopituitarism after traumatic brain injury and subarachnoid haemorrhage. (16421764)
2006
28
Prevalence of hypopituitarism and growth hormone deficiency in adults long-term after severe traumatic brain injury. (15853820)
2005
29
Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome. (15690545)
2005
30
Hypopituitarism after traumatic brain injury. (15879352)
2005
31
Diagnosis and treatment of hypopituitarism: an update. (16508719)
2005
32
Evidence for developmental hypopituitarism in ill preterm infants. (15129226)
2004
33
Failure of recombinant human growth hormone treatment to improve congestive heart failure in hypopituitarism. (15505763)
2004
34
Hormone replacement therapy in hypopituitarism. (15155105)
2004
35
Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. (14557462)
2003
36
Severe hyponatremia as a frequent revealing sign of hypopituitarism after 60 years of age. (12943518)
2003
37
The spectrum of hypopituitarism caused by PROP1 mutations. (12464226)
2002
38
Hypopituitarism following cerebral oedema with diabetic ketoacidosis. (12244015)
2002
39
The "quality of life-assessment of growth hormone deficiency in adults" questionnaire: can it be used to assess quality of life in hypopituitarism? (11344182)
2001
40
Pallister-Hall syndrome with stenosis of the cricoid cartilage and microphallus without hypopituitarism. (11693785)
2001
41
Autoimmune hypopituitarism in patients with coeliac disease: symptoms confusingly similar. (11346213)
2001
42
Hyperinsulinemic hypoglycemia associated with possible hypopituitarism in a patient with acquired immunodeficiency syndrome. (11155218)
2000
43
Effects of long-term treatment with GH in the bone mineral density of adults with hypopituitarism and GH deficiency and after discontinuation of GH replacement. (10741688)
2000
44
Very-low-density lipoprotein apolipoprotein B100 kinetics in adult hypopituitarism. (10459574)
1999
45
Retinitis pigmentosa, hypopituitarism, nephronophthisis, and mild skeletal dysplasia (RHYNS): a new syndrome? (9375913)
1997
46
Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. (1509263)
1992
47
Syndrome of mental retardation, facial anomalies, hypopituitarism, and distal arthrogryposis in sibs. (2240046)
1990
48
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. (3215147)
1988
49
A case of Klinefelter's syndrome with acquired hypopituitarism. (6695538)
1984
50
Hypopituitarism associated with transsphenoidal meningoencephalocele. (7173265)
1982

Genetic Variations for Hypopituitarism

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Expression for genes affiliated with Hypopituitarism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypopituitarism

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Pathways for genes affiliated with Hypopituitarism

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Hypopituitarism

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hypopituitarism according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CRHBP, TRH, HSD11B1
2forskolin44 49 1112.4POU1F1, GHRH, HSD11B1, CRH, POMC
311 deoxycortisol4410.3PRL, CYP21A2, POMC, SHBG, CRH
4fenfluramine28 44 1112.3TRH, CRH, GHRH, POMC, PRL
5oxandrolone44 1111.3GHRL, GH1, IGF1, SHBG
6acth 1-244410.3PRL, POMC, CYP21A2, CRH
7bromocriptine28 44 1112.3POU1F1, TRH, SHBG, PRL, GHRH, GNRH1
8cortisone44 2411.3HSD11B1, POMC, CRH, CYP21A2, GH1, IGF1
9ghrp4410.3GHRL, IGF1, PRL, TRH, GHRH, GH1
10leuprolide acetate4410.2GNRH1, GH1, PRL, CYP21A2, IGF1, SHBG
11norepinephrine44 11 2412.2CYP21A2, POMC, TRH, GHRH, GNRH1, PRL
12pyridostigmine44 1111.2CRH, GHRL, GHRH, TRH, IGF1, PRL
13spironolactone49 44 59 28 1114.2POMC, CYP21A2, CRH, GNRH1, SHBG
14naltrexone44 49 28 1113.2GNRH1, CRH, POMC, IGF1, PRL, GH1
1517-hydroxyprogesterone44 2411.2SHBG, CYP21A2, POMC, PRL, GNRH1, CRH
16hexarelin44 2811.2POMC, IGF1, PRL, GH1, GHRH, GHRL
17clonidine44 28 1112.2GHRH, TRH, POMC, GH1, PRL, IGF1
18clomiphene citrate4410.2CYP21A2, IGF1, SHBG, PRL, GH1, CRH
19opiate4410.2CRH, GNRH1, GH1, PRL, GHRH, POMC
20metformin44 49 1112.2IGF1, GNRH1, GH1, SHBG, POMC, GHRL
21allopregnanolone4410.1POMC, GNRH1, CRH, SHBG
22corticosterone44 59 2412.1CRH, PRL, POMC, CYP21A2, GHRL, HSD11B1
2311beta-hydroxysteroid4410.1POMC, GH1, CRH, HSD11B1, CYP21A2
24naloxone44 49 28 1113.1POMC, TRH, PRL, GH1, GNRH1, GHRH
25dopamine44 28 11 2413.1IGF1, GNRH1, CRH, TRH, SHBG, GHRL
26mifepristone44 59 28 1113.0HSD11B1, GNRH1, POMC, SHBG, PRL, CRH
27dhea4410.0CYP21A2, POMC, IGF1, SHBG, GH1, PRL
28androstenedione44 2411.0CYP21A2, CRH, GNRH1, HSD11B1, POMC, IGF1
29triiodothyronine4410.0GHRL, GHRH, GH1, PRL, SHBG, IGF1
30dehydroepiandrosterone sulfate4410.0CYP21A2, POMC, IGF1, GNRH1, CRH, GHRL
31octreotide44 59 28 1113.0POMC, TRH, GNRH1, CRH, GHRL, GHRH
32epinephrine44 11 2412.0CRH, GNRH1, AQP2, POMC, CYP21A2, GHRL
33alanine449.9GH1, SHBG, CRH, POU1F1, POMC, AQP2
34cocaine44 1110.9GNRH1, POMC, TRH, PRL, GHRL, CRH
35adenylate449.9POMC, SHBG, GHRH, GNRH1, CRH, GH1
36ribonucleic acid449.8IGF1, POU1F1, POMC, CYP21A2, PRL, GH1
37thyroxine44 2410.8CRH, GHRL, GHRH, GH1, PRL, SHBG
38vitamin d449.8CRH, GHRH, SHBG, IGF1, POU1F1, GHRL
39dihydrotestosterone44 28 11 2412.8IGF1, PRL, GH1, GNRH1, CYP21A2, SHBG
40hydrocortisone44 2 59 1112.7POMC, CYP21A2, AQP2, TRH, IGF1, HSD11B1
41steroid449.7POU1F1, CYP21A2, AQP2, IGF1, POMC, CRH
42glucose449.7TRH, CYP21A2, HSD11B1, GHRL, GHRH, PRL
43testosterone44 59 11 2412.7HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
44estradiol44 11 2411.6HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
45arginine449.6POMC, CYP21A2, AQP2, PRL, SHBG, POU1F1
46gnrh449.6CYP21A2, POMC, TRH, IGF1, LHX3, HESX1
47progesterone44 59 28 11 2413.6IGF1, TRH, POU1F1, POMC, CYP21A2, AQP2
48acth449.5HSD11B1, CRH, GNRH1, HESX1, CYP21A2, POMC
49dexamethasone44 49 28 1112.4HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
50creatinine449.4SHBG, IGF1, GH1, AQP2, GHRL, POMC

GO Terms for genes affiliated with Hypopituitarism

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16Gene Ontology
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Cellular components related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3POMC, GHRL
2varicosityGO:04319610.0CRHBP, CRH
3secretory granuleGO:03014110.0CRHBP, PRL, TRH, POMC
4extracellular spaceGO:0056159.7GNRH1, CRH, CRHBP, GHRL, GHRH, GH1
5extracellular regionGO:0055769.6POMC, GNRH1, CRH, GHRL, GHRH, GH1

Biological processes related to Hypopituitarism according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.6LHX4, LHX3
2cellular response to cocaineGO:07131410.6CRH, CRHBP
3positive regulation of cortisol secretionGO:05146410.6CRH, GHRL
4negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.6CRH, GHRL
5positive regulation of growth hormone secretionGO:06012410.5GHRL, GHRH
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.5GHRH, GH1, IGF1
7positive regulation of corticotropin secretionGO:05146110.5GHRL, CRH
8glucocorticoid biosynthetic processGO:00670410.5CYP21A2, CRH, HSD11B1
9ovulation cycleGO:04269810.5GNRH1, PRL
10growth hormone secretionGO:03025210.5GHRL, GHRH
11positive regulation of multicellular organism growthGO:04001810.5GHRL, GHRH, GH1, POU1F1
12parturitionGO:00756710.5CRH, PRL
13hormone-mediated signaling pathwayGO:00975510.4TRH, GHRL, CRHBP
14response to ethanolGO:04547110.4GNRH1, CRH, PRL, TRH
15female pregnancyGO:00756510.3AQP2, PRL, CRHBP, CRH, GNRH1
16synaptic transmission, dopaminergicGO:00196310.3CRHBP, CRH
17positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
18regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.3CRHBP, CRH
19negative regulation of apoptotic processGO:04306610.2PROP1, GHRL, GNRH1, LHX3, LHX4
20cell-cell signalingGO:00726710.2POMC, TRH, GHRH, GNRH1
21organ morphogenesisGO:00988710.2LHX4, LHX3, SOX3
22hypothalamus developmentGO:02185410.0CRH, SOX3
23signal transductionGO:00716510.0GNRH1, CRH, CRHBP, IGF1, TRH, POMC

Molecular functions related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3GH1, PRL
2growth hormone-releasing hormone activityGO:01660810.0GHRH, GHRL
3hormone activityGO:0051799.8GH1, POMC, IGF1, PRL, GNRH1, CRH

Products for genes affiliated with Hypopituitarism

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Sources for Hypopituitarism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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