Hypopituitarism malady

NIH Rare Diseases: Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  The pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  These hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  Symptoms of this condition vary and depend on which hormones are affected.  Treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones.³⁰

MalaCards: Hypopituitarism, also known as pituitary insufficiency nos, is related to sheehan syndrome and septooptic dysplasia. An important gene associated with Hypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and G alpha (s) signalling events. The compounds glucose and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and thyroid, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Wikipedia: Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced...⁴⁴ more...

Aliases & Descriptions:

hypopituitarism 6 30 17 8 32 43 pituitary insufficiency nos 6

pituitary insufficiency 30

Diseases related to hypopituitarism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 537)

id	Related Disease	Score	Top Affiliating Genes
1	sheehan syndrome	29.8	INS, IGF1, CRH, PRL, POMC
2	septooptic dysplasia	29.6	HESX1, SOD1
3	hypothyroidism	29.0	LEP, IGFBP3, GHRL, TRH, SHBG
4	ectrodactyly	28.8	GLI2, PRL, SIX3
5	traumatic brain injury	28.3	LEP, INS, IL6, IGF1, GH1, GHRH
6	lymphocytic hypophysitis	28.0	IGF1, PRL, POMC
7	adrenocorticotropic hormone deficiency	27.8	GHRH, TBX19, CRH, POMC
8	empty sella syndrome	27.7	INS, IGFBP3, TRH, PRL, POMC
9	21-hydroxylase deficiency	27.6	BRD2, GNRH1, CYP21A2, POMC
10	acid-labile subunit	27.2	APOA1, IGFBP3, IGF1, GH1, GHR
11	brain injury	27.1	LEP, INS, IL6, IGF1, GH1, GHRH
12	turner syndrome	27.0	CGA, IGFBP3, IGF1, GH1, GHR, CYP21A2
13	addison's disease	26.9	SERPINA6, INS, HSD11B1, TRH, CYP21A2, SST
14	pituitary apoplexy	26.8	BRD2, AVP, INS, GNRH1, GH1, TRH
15	medulloblastoma	26.6	INS, GLI2, OTX2, SST, SOD1, SOX1
16	craniopharyngioma	26.6	BRD2, LEP, CGA, AVP, INS, IL6
17	panhypopituitarism	26.4	LHX3, LHX4, AVP, IGF1, GH1, GHR
18	pituitary hypoplasia	26.4	PBX1, LHX3, LHX4, ESX1, GH1, GHRH
19	hemorrhagic fever with renal syndrome	25.9	INS, IL6, IGF1, CRP, PRL
20	headache	25.4	INS, IL6, IGF1, SST, PRL, SOD1
21	hemorrhagic fever	25.2	INS, IL6, IGF1, CYP19A1, CRP, PRL
22	combined pituitary hormone deficiency	25.1	PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
23	pituitary hormone deficiency	25.1	PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
24	myotonic dystrophy	24.8	GCG, LEP, INS, IL6, IGFBP3, IGF1
25	hyperprolactinemia	24.4	BRD2, CGA, INS, IL6, IGFBP3, IGF1
26	meningitis	24.2	AVP, IL6, IGFBP3, CYP19A1, CRP, SOD1
27	klinefelter's syndrome	23.7	BRD2, LEP, CGA, INS, IL6, GNRH1
28	pituitary adenoma	22.8	PBX1, LEP, CGA, FSHB, INS, IL6
29	anorexia nervosa	21.7	GCG, PBX1, LEP, AVP, INS, IL6
30	growth hormone deficiency	21.4	PBX1, LHX3, LHX4, LEP, INS, IL6
31	diabetes mellitus	20.5	GCG, PBX1, LEP, CGA, AVP, INS
32	acromegaly	20.5	GCG, BRD2, PBX1, LEP, INS, IL6
33	obesity	20.4	GCG, SERPINA6, PBX1, LEP, CGA, INS
34	adenoma	19.6	GCG, BRD2, PBX1, LEP, CGA, FSHB
35	thyroiditis	17.3	GCG, SERPINA6, PBX1, LHX3, LEP, CGA
36	carcinoma	15.2	GCG, SERPINA6, BRD2, PBX1, LEP, CGA
37	neonatal thyrotoxicosis	13.8	LHX3, TRH, PROP1
38	growth hormone deficient dwarfism	13.8	GH1, POU1F1
39	11-beta-hydroxylase deficiency	13.7	GH1, CYP21A2, SHBG
40	insulin-like growth factor 1 resistance to	13.7	IGFBP3, IGF1, GH1
41	laron dwarfism	13.7	IGF1, GH1, GHR
42	tsh producing pituitary tumor	13.7	GH1, PRL
43	chromophobe adenoma	13.7	GH1, PRL
44	idiopathic juvenile osteoporosis	13.7	IGFBP3, IGF1, GH1
45	marasmus	13.7	IGFBP3, GH1, SHBG
46	insulin-like growth factor i deficiency	13.7	IGF1, GHR
47	melancholia	13.7	TRH, CRH, PRL, POMC
48	pseudohypoparathyroidism type ia	13.7	IGF1, GH1, TRH, PRL
49	alopecia universalis	13.7	INS, CYP21A2, POMC
50	borjeson-forssman-lehmann syndrome	13.7	LHX3, LHX4, HESX1, PROP1, SOX3, POU1F1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypopituitarism:

²²

MGI Mouse Phenotypes related to hypopituitarism:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.4	POU1F1
2	renal/urinary system phenotype	MP:0005367	8.9	OXT, GHR, GNRH1, AQP2, INS, AVP
3	embryogenesis phenotype	MP:0005380	8.5	SIX3, SOX1, PRL, HESX1, OTX2, ESX1
4	endocrine/exocrine gland phenotype	MP:0005379	8.5	PROP1, SOX21, SOX3, POU1F1, HESX1, BRD2
5	hearing/vestibular/ear phenotype	MP:0005377	8.2	SOX2, SOD1, HESX1, CYP19A1, OTX2, GLI2
6	integument phenotype	MP:0010771	8.2	POMC, SOX21, PRL, OXT, CRH, CYP19A1
7	respiratory system phenotype	MP:0005388	8.0	CRH, HESX1, PROP1, SOX2, SIX3, OTX2
8	adipose tissue phenotype	MP:0005375	7.9	POMC, CYP19A1, GHRL, GHRHR, GHR, GH1
9	skeleton phenotype	MP:0005390	7.6	SIX3, CYP19A1, OTX2, GHRHR, GLI2, GNRH1
10	normal phenotype	MP:0002873	7.4	CYP19A1, SST, CRH, HESX1, SOX15, SOX2
11	digestive/alimentary phenotype	MP:0005381	6.8	OTX2, SST, OXT, SOX2, SIX3, GHRL
12	nervous system phenotype	MP:0003631	6.8	GHRHR, TRH, TBX19, OTX2, CYP19A1, CRH
13	reproductive system phenotype	MP:0005389	6.6	GHRH, GHRHR, TBX19, OTX2, SRY, OXT
14	liver/biliary system phenotype	MP:0005370	6.5	HSD11B1, GH1, GHR, GHRH, CYP19A1, PRL
15	mortality/aging	MP:0010768	6.2	SRY, HESX1, OXT, PROP1, SOX1, SOX2
16	cellular phenotype	MP:0005384	5.8	OTX2, CYP19A1, CRH, PROP1, SOD1, SOX1
17	cardiovascular system phenotype	MP:0005385	5.6	OTX2, CYP19A1, CRP, OXT, SOD1, POMC
18	growth/size phenotype	MP:0005378	5.3	CYP19A1, OTX2, TRH, GHRHR, GHRH, SST
19	immune system phenotype	MP:0005387	5.2	SST, CRH, CRP, PRL, SOD1, SOX2
20	behavior/neurological phenotype	MP:0005386	4.3	OXT, CRHBP, CRH, SST, CYP19A1, PRL
21	homeostasis/metabolism phenotype	MP:0005376	2.0	GCG, IGFBP3, IGF1, GNRH1, HSD11B1, GLI2

Articles related to hypopituitarism:

(show top 50)    (show all 84)

id	Title	Authors	Year	Affiliating Genes
1	Incomplete deficiency of hypothalamic hormones in hyp othalamic hypopituitarism associated with an old traumatic brain injury. (19638713)	Saito T.... Ishikawa S.E.	2009	INS
2	Absence of SIX3 mutations in patients with congenital hypopituitarism. (19921650)	Gaston-Massuet C.... Martinez-Barbera J.P.	2009	SIX3
3	Congenital hypopituitarism: clinico-radiological corr elation. (20020580)	Dutta P.... Bhadada S.	2009	INS
4	Genetic forms of hypopituitarism and their manifestat ion in the neonatal period. (19762173)	Alatzoglou K.S.... Dattani M.T.	2009	OTX2, SOX3, LHX3
5	Problems typical for patients with hypopituitarism - a case presentation (18577349)	Starzyk J.... Wojcik M.	2008	PROP1
6	Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. (18493103)	Kageyama K.... Suda T.	2008	INS, CRH
7	Congenital hypopituitarism: report of 23 cases (18949183)	Lammoglia J.J.... Mericq V.	2008	HESX1
8	Heterozygous mutation of HESX1 causing hypopituitarism and multiple anatomical malformations without features of septo-optic dysplasia. (18852528)	Corneli G.... Bona G.	2008	HESX1
9	Hypopituitarism and HIV-infection: a new comorbidity in the HAART era? (19020383)	Zirilli L.... Rochira V.	2008	IGF1
10	Developmental disorders of the hypothalamus and pituitary gland associated with congenital hypopituitarism. (18279788)	Mehta A.... Dattani M.T.	2008	SOX3, LHX3, LHX4
11	High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome. (18430769)	Stojanovic M.... Popovic V.	2008	IGF1, PRL
12	Hypopituitarism oddities: congenital causes. (18174732)	Kelberman D.... Dattani M.T.	2007	PRL, SOX3, LHX3
13	Hormonal, pituitary magnetic resonance, LHX4 and HESX1 evaluation in patients with hypopituitarism and ectopic posterior pituitary lobe. (17201807)	Melo M.E.... Knoepfelmacher M.	2007	HESX1
14	Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation. (17127446)	Wong J.... Thomas P.Q.	2007	SOX3
15	HESX1 mutations are an uncommon cause of septooptic dysplasia and hypopituitarism. (17148560)	McNay D.E.... Dattani M.T.	2007	SOD1, HESX1
16	MRI findings and genotype analysis in patients with childhood onset growth hormone deficiency--correlation with severity of hypopituitarism. (17642419)	Zimmermann A.... Bettendorf M.	2007	PROP1, POU1F1
17	The role of transcription factors implicated in anterior pituitary development in the aetiology of congenital hypopituitarism. (17438671)	Kelberman D.... Dattani M.T.	2006	SOX3, LHX3, TBX19
18	Effect of thyroxine replacement on serum IGF-I, IGFBP-3 and the acid-labile subunit in patients with hypothyroidism and hypopituitarism. (17121519)	Schmid C.... Wiesli P.	2006	IGF1, IGFBP3
19	Hypopituitarism findings in patients with primary bra in tumors 1 year after neurosurgical treatment: preliminary report. (16840829)	De Marinis L.... Ghigo E.	2006	GHRH
20	Hypopituitarism. (17077946)	Ascoli P.... Cavagnini F.	2006	POMC, PRL, GH1
21	Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. (15800844)	Woods K.S.... Dattani M.T.	2005	SOX3
22	Congenital hypopituitarism: when should transcriptio n factor gene screenings be performed? (15105786)	Reynaud R.... Brue T.	2004	GHRH
23	Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H). (15070931)	Rosilio M.... Attanasio A.F.	2004	IGF1
24	Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency. (12807504)	Aimaretti G.... Ghigo E.	2003	IGF1
25	Congenital hypopituitarism as a cause of undetectable estriol levels in the maternal triple-marker screen. (12970278)	Marshall I.... Vogiatzi M.V.	2003	CYP19A1
26	The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism. (12699442)	Isidori A.M.... Monson J.P.	2003	IGF1, SHBG, SERPINA6
27	Long-term follow-up of childhood-onset hypopituitarism in patients with the PROP-1 gene mutation. (14530604)	Pavel M.E.... Dorr H.G.	2003	PROP1
28	Association of Turner's syndrome and hypopituitarism: a patient report. (12948305)	Gallicchio C.T.... GuimarALes M.M.	2003	INS
29	The spectrum of hypopituitarism caused by PROP1 mutations. (12464226)	Mody S.... Parks J.S.	2002	PROP1
30	Effect of various doses of biosynthetic growth hormo ne on levels of IGF-I binding protein 3 (IGFBP-3) in patients with hypopituitar ism and growth hormone deficiency (12688134)	JustovA! V.... Marek J.	2002	IGFBP3
31	The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months. (11701703)	McConnell E.M.... Bell P.M.	2001	INS, GH1
32	Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone Plus arginine in children and adults with congenital hypopituitarism. (11297586)	Maghnie M.... Ghigo E.	2001	GHRH
33	Inflammatory cardiovascular risk markers in women with hypopituitarism. (11739438)	Sesmilo G.... Klibanski A.	2001	IGF1, IL6, CRP
34	DHEA-S levels in hypopituitaric patients with severe GH deficiency are strongly reduced across lifespan. Comparison with IGF-I levels before and during rhGH replacement. (10698044)	Aimaretti G.... Ghigo E.	2000	IGF1
35	Transcription factors of the anterior pituitary and combined hypopituitarism (10520413)	Vallette S.... Brue T.	1999	LHX3
36	Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic dystrophy disease. (11081190)	GA^mez J.M.... MartA-nez-Matos J.A.	1999	IGF1, LEP, GH1
37	Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene. (9920061)	Rosenbloom A.L.... Parks J.S.	1999	PROP1
38	The molecular basis of hypopituitarism. (9554467)	Radovick S.... Wondisford F.E.	1998	POU1F1
39	Severe congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation. (9627600)	Ward L.... Van Vliet G.	1998	PRL, POU1F1
40	Hydrocortisone replacement therapy in children and adolescents with hypopituitarism. (9302370)	DeVile C.J.... Stanhope R.	1997	INS
41	Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. (8881449)	Al-Shoumer K.A.... Johnston D.G.	1996	GH1
42	Spontaneous recovery from post-traumatic hypopituitarism. (8796342)	Iglesias P.... Diez J.J.	1996	INS, TRH
43	Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. (8530591)	Arafah B.M.... Selman W.R.	1995	PRL
44	Partial hypopituitarism in Klinefelter's syndrome. (7779675)	Hughes T.A.... Borsey D.Q.	1995	PRL
45	Comparison of adrenocorticotropin and adrenal steroid responses to corticotropin-releasing hormone versus metyrapone testing in patients with hypopituitarism. (7970937)	Riddick L.... Pang S.	1994	POMC, CRH
46	Serum growth hormone response to growth hormone-releasing hormone in non-obese and obese adults with hypopituitarism. (8510526)	Bing-You R.G.... Oppenheim D.S.	1993	GH1
47	Hypopituitarism after tuberculous meningitis in childhood. (8460856)	Lam K.S.... Ma H.T.	1993	POMC
48	Superiority of magnetic resonance imaging (MRI) over computerized tomography (CT) in diagnosis of hypopituitarism (1345561)	Zgliczynski W.... Walecki J.	1992	PBX1
49	Metabolic effects of hypopituitarism and acromegaly. (1806480)	SAPnksen P.H.... Cuneo R.	1991	INS
50	An unusual association of transient resolving thyrot oxicosis due to painless thyroiditis, hypopituitarism and central diabetes insi pidus associated with spontaneous pituitary apoplexy (2307257)	Sasaki H.... Okumura M.	1990	GH1

Genes related to hypopituitarism according to GeneCards:

(show all 50)

id	Symbol	Description	Score	GeneCards Section Context
1	SOX3	SRY (sex determining region Y)-box 3	11.0	Orthologs, Publications
2	PROP1	PROP paired-like homeobox 1	11.0	Publications
3	HESX1	HESX homeobox 1	11.0	Publications
4	LHX3	LIM homeobox 3	11.0	Publications
5	LHX4	LIM homeobox 4	11.0	Publications
6	POU1F1	POU class 1 homeobox 1	11.0	Publications
7	GHRH	growth hormone releasing hormone	11.0	Publications
8	CRHBP	corticotropin releasing hormone binding protein	11.0
9	TRH	thyrotropin-releasing hormone	11.0	Publications
10	POMC	proopiomelanocortin	11.0	Publications
11	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	11.0
12	GH1	growth hormone 1	11.0	Publications
13	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
14	AQP2	aquaporin 2 (collecting duct)	11.0
15	CRH	corticotropin releasing hormone	11.0	Publications
16	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
17	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
18	PRL	prolactin	11.0	Publications
19	SHBG	sex hormone-binding globulin	11.0	Publications
20	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
21	CGA	glycoprotein hormones, alpha polypeptide	11.0
22	LEP	leptin	11.0	Publications
23	INS	insulin	11.0	Publications
24	GHR	growth hormone receptor	11.0
25	GHRL	ghrelin/obestatin prepropeptide	11.0
26	SOX1	SRY (sex determining region Y)-box 1	11.0	Orthologs
27	SOX14	SRY (sex determining region Y)-box 14	11.0	Orthologs
28	SOX21	SRY (sex determining region Y)-box 21	11.0	Orthologs
29	SOX15	SRY (sex determining region Y)-box 15	11.0	Orthologs
30	SIX3	SIX homeobox 3	11.0	Publications
31	ESX1	ESX homeobox 1	11.0
32	SOX2	SRY (sex determining region Y)-box 2	11.0	Publications, Orthologs
33	FSHB	follicle stimulating hormone, beta polypeptide	11.0	UniProt Related
34	OTX2	orthodenticle homeobox 2	11.0	Publications
35	SRY	sex determining region Y	11.0	Orthologs
36	TBX19	T-box 19	11.0	Publications
37	GHRHR	growth hormone releasing hormone receptor	11.0	Publications
38	AVP	arginine vasopressin	11.0
39	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
40	BRD2	bromodomain containing 2	11.0
41	GLI2	GLI family zinc finger 2	11.0	Publications
42	PBX1	pre-B-cell leukemia homeobox 1	11.0	Publications
43	GCG	glucagon	11.0
44	OXT	oxytocin, prepropeptide	11.0	Publications
45	APOA1	apolipoprotein A-I	11.0	Publications
46	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
47	SST	somatostatin	11.0
48	SOD1	superoxide dismutase 1, soluble	11.0	Publications
49	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
50	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to hypopituitarism according to GeneDecks:

(show all 25)

id	Pathway	Score	Top Affiliating Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.7	TRH
2	G alpha (s) signalling events38	10.1	CGA, AVP, FSHB, POMC
3	Telomerase Components in Cell Signaling36	10.1	IGF1, GNRH1, GH1, GHRH
4	Jak-STAT signaling pathway20	10.0	PRL, GHR, GH1, LEP
5	Development_Role of Activin A in cell differentiation and proliferation41	10.0	FSHB, CGA, LHX3, PBX1
6	Development Role of Activin A in cell differentiation and proliferation10	10.0	FSHB, CGA, LHX3, PBX1
7	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.0	POMC, CRP, TRH, LEP
8	Transcription factors in neurogenesis10	10.0	SIX3, SOX3, OTX2, PBX1
9	Selected targets of CREB110	9.9	CRH, INS, AVP, GCG
10	Glioma Invasiveness36	9.9	GHRH, GH1, GNRH1
11	G alpha (q) signalling events38	9.8	GNRH1, GHRL, TRH, OXT
12	Neuroactive ligand-receptor interaction20	9.7	PRL, GHRHR, GHR, GH1, FSHB, CGA
13	mTOR Pathway36	9.4	GHRH, GH1, GNRH1, IGF1, IL6, INS
14	eIF2 Pathway36	9.4	GHRH, GH1, GNRH1, IGF1, IL6, INS
15	Apoptotic Pathways in Synovial Fibroblasts36	9.4	GHRH, GH1, GNRH1, IGF1, IL6
16	Nanog in Mammalian ESC Pluripotency36	9.3	SOX2, GHRH, GH1, GNRH1, IGF1, IL6
17	p70S6K Signaling36	9.3	GHRH, GH1, GNRH1, IGF1, IL6, INS
18	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.3	CYP19A1, IGF1, IL6, CGA
19	Selected targets of GCR-alpha10	9.3	LEP, GHR, IL6, INS, FSHB, CGA
20	p53 Mediated Apoptosis36	9.2	GHRH, GH1, GNRH1, IGF1, IL6
21	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.2	CGA, IL6, IGF1, CYP19A1
22	JAK-STAT Pathway36	9.2	PRL, GHRH, GHR, GH1, GNRH1, IGF1
23	eNOS Signaling36	9.0	GHRH, GH1, GNRH1, IGF1, AQP2, IL6
24	Molecular Mechanisms of Cancer36	8.8	SOX3, SOX21, SOX2, SOX15, SOX14, SOX1
25	Activation of PKA through GPCR36	8.5	CRP, GHRH, GH1, GNRH1, IGF1, IL6

Compounds related to hypopituitarism according to GeneDecks:

(show top 50)    (show all 241)

id	Compound	Score	Top Affiliating Genes
1	glucose32	9.9	GCG, AVP, GHRHR, TRH
2	c-peptide32	9.9	GCG, LEP, GHR, GHRL, CYP21A2, SHBG
3	naltrexone32 34 9 9	12.9	PRL, CRH, GHRH, GH1, GNRH1, IGF1
4	cortisone32 18	10.8	LEP, CRH, POMC, CYP21A2, GH1, HSD11B1
5	bromocriptine32 9 9	11.7	GH1, GHRH, TRH, SST, PRL, POMC
6	11 deoxycortisol32	9.6	CYP21A2, SHBG, PRL, CGA, POMC, SERPINA6
7	pyridostigmine32 9 9	11.5	GH1, GHRH, GHRL, TRH, SST, CRH
8	cabergoline32 9 9	11.3	PRL, CGA, SST, GHR, GH1, GNRH1
9	lanreotide32	9.3	SST, GHRH, GHR, GH1, IGF1, IGFBP3
10	leuprolide acetate32	9.3	CGA, FSHB, IGF1, GNRH1, GH1, GHR
11	epinephrine32 9 18 9	12.2	GCG, LEP, CGA, INS, AQP2, IGFBP3
12	triiodothyronine32	9.1	SHBG, PRL, POMC, TRH, GHRL, GHRH
13	17-hydroxyprogesterone32 18	10.1	SERPINA6, PBX1, CGA, GNRH1, CYP19A1, CYP21A2
14	clomiphene citrate32	9.0	PRL, CGA, FSHB, INS, IGFBP3, IGF1
15	ghrp32	8.9	PBX1, IGFBP3, GH1, GHR, GHRH, GHRHR
16	acipimox32	8.9	GCG, LEP, INS, APOA1, IGF1, GH1
17	corticosterone32 18	9.9	CYP21A2, GH1, HSD11B1, OXT, GHRL, GCG
18	cyproteroneacetate32	8.8	PRL, SERPINA6, INS, APOA1, CYP19A1, SHBG
19	naloxone32 34 9 9	11.8	TRH, SST, CRH, OXT, PRL, POMC
20	clonidine32 9 9	10.8	LEP, CGA, APOA1, IGFBP3, IGF1, GH1
21	dhea32	8.7	SERPINA6, LEP, INS, IGFBP3, IGF1, HSD11B1
22	buserelin32 9 9	10.7	CGA, FSHB, IGFBP3, IGF1, GNRH1, CYP19A1
23	dihydrotestosterone32 9 18 9	11.7	SERPINA6, LEP, CGA, IGFBP3, IGF1, GNRH1
24	octreotide32 42 9 9	11.6	CRH, PRL, POMC, GCG, INS, IGFBP3
25	ribonucleic acid32	8.6	SERPINA6, CGA, FSHB, IGFBP3, IGF1, GNRH1
26	dopamine32 9 18 9	11.6	OXT, POU1F1, SST, TRH, GHRL, GHRH
27	forskolin32 42 9 9	11.5	CGA, TRH, CYP21A2, CRH, CRHBP, OXT
28	glutamate32	8.4	GCG, LEP, INS, IGFBP3, OXT, GNRH1
29	hexarelin32	8.4	SST, CRH, OXT, PRL, POMC, GHRL
30	megestrol acetate32	8.3	LEP, IL6, IGFBP3, IGF1, CYP19A1, SHBG
31	progestin32	8.3	OXT, APOA1, POMC, SHBG, CYP19A1, IGF1
32	gnrh32	8.2	IGFBP3, IGF1, GH1, GHR, GHRH, GHRL
33	dehydroepiandrosterone sulfate32	8.2	PRL, POMC, SHBG, CRH, CYP21A2, SERPINA6
34	androstenedione32 18	9.1	IGFBP3, CYP19A1, CYP21A2, CRH, SHBG, PRL
35	creatinine32	7.9	POMC, OXT, GCG, LEP, CGA, AQP2
36	metformin32 34 9 9	10.9	GCG, LEP, CGA, INS, APOA1, IGF1
37	estradiol32 9 18 9	10.9	POMC, PRL, SERPINA6, CYP19A1, PBX1, CGA
38	progesterone32 42 9 18 9	11.8	CYP19A1, CYP21A2, CRH, CRHBP, OXT, PRL
39	adenylate32	7.7	POMC, GHRL, SHBG, CRH, SST, CGA
40	thyroxine32 18	8.5	SERPINA6, LEP, CGA, INS, APOA1, IGFBP3
41	testosterone32 9 18 9	10.4	APOA1, IGFBP3, GNRH1, GHR, TRH, CYP21A2
42	hydrocortisone32 9 9	9.0	POMC, PRL, SERPINA6, PBX1, INS, IL6
43	steroid32	6.9	OXT, PRL, PROP1, POMC, POU1F1, SHBG
44	alanine32	6.8	INS, IL6, AQP2, APOA1, IGFBP3, HSD11B1
45	cycloheximide32	6.6	IGFBP3, GH1, LEP, GCG, CRP, CRH
46	norepinephrine32 9 18 9	9.5	IGFBP3, GNRH1, GH1, GHRH, GHRL, TRH
47	acth32	5.8	GHRL, TRH, TBX19, CYP21A2, SST, CRH
48	dexamethasone32 42 34 9 9	9.5	SHBG, PRL, POMC, POU1F1, CRHBP, GNRH1
49	estrogen32	5.5	GCG, SERPINA6, PBX1, LEP, CGA, FSHB
50	arginine32	5.3	TRH, CYP19A1, CYP21A2, SST, CRH, SHBG

Cellular components related to hypopituitarism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor binding protein complex	GO:016942	10.2	IGFBP3, IGF1
2	secretory granule	GO:030141	8.2	TRH, CRHBP, OXT, POMC, GHRL, GHRHR
3	nucleus	GO:005634	5.9	SOX14, SOX1, SOD1, HESX1, SOX15, SOX2
4	extracellular space	GO:005615	5.3	GCG, GHRL, SST, CRH, CRHBP, CRP
5	extracellular region	GO:005576	4.6	GHRH, GHRL, TRH, SST, CRH, CRP

Biological processes related to hypopituitarism according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	medial motor column neuron differentiation	GO:021526	10.6	LHX4, LHX3
2	glucocorticoid biosynthetic process	GO:006704	10.5	HSD11B1, CYP21A2, CRH
3	positive regulation of cortisol secretion	GO:051464	10.5	CRH, GHRL
4	negative regulation of circadian sleep/wake cycle, REM sleep	GO:042322	10.5	CRH, GHRL
5	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.4	GHR, GH1, IGF1
6	hormone-mediated signaling pathway	GO:009755	10.4	CRHBP, TRH, GHRL, GHR
7	positive regulation of growth hormone secretion	GO:060124	10.4	GHRH, GHRHR, GHRL
8	growth hormone secretion	GO:030252	10.3	GHRL, GHRHR, GHRH
9	peptide hormone processing	GO:016486	10.3	CGA, FSHB, POMC
10	hormone metabolic process	GO:042445	10.3	CRHBP, GHRHR, LEP
11	positive regulation of circadian sleep/wake cycle, non-REM sleep	GO:046010	10.3	GHRL, GHRH
12	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.3	PRL, GHR, GH1
13	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.2	GHRHR, GHRH, GH1, IGF1, IGFBP3
14	bone mineralization involved in bone maturation	GO:035630	10.2	IGF1, LEP
15	chromatin organization	GO:006325	10.2	SOX2, SOX15, SOX1
16	positive regulation of multicellular organism growth	GO:040018	10.2	GHRL, GHRHR, GHRH, GHR, GH1
17	maternal aggressive behavior	GO:002125	10.1	AVP, CRHBP, OXT
18	eating behavior	GO:042755	10.1	LEP, TRH, OXT
19	pituitary gland development	GO:021983	10.0	SOX3, SOX2, TBX19, GLI2, LHX3
20	positive regulation of cAMP biosynthetic process	GO:030819	9.9	GCG, AVP, GHRH, GHRHR
21	regulation of multicellular organism growth	GO:040014	9.8	SOD1, PRL, GHR, IGF1
22	positive regulation of JAK-STAT cascade	GO:046427	9.8	PRL, GH1, IL6
23	adrenal gland development	GO:030325	9.7	APOA1, CYP19A1, CRH
24	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	9.6	GHR, GH1, IL6, LEP
25	female pregnancy	GO:007565	9.6	LEP, PRL, OXT, CRHBP, CRH, GNRH1
26	positive regulation of STAT protein import into nucleus	GO:2000366	9.6	IL6, LEP
27	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	GHR, GH1, IGF1, IL6, INS
28	cell-cell signaling	GO:007267	9.4	POMC, CGA, AVP, INS, GNRH1, GHRH
29	response to estradiol stimulus	GO:032355	9.4	OXT, CYP19A1, GHR, GH1
30	positive regulation of MAPK cascade	GO:043410	9.4	SOX2, IGF1, IGFBP3, IL6, INS, LEP
31	response to ethanol	GO:045471	9.1	SOD1, TRH, GNRH1, AVP
32	negative regulation of apoptotic process	GO:043066	8.9	PROP1, GHRL, IL6, INS, AVP, LEP
33	signal transduction	GO:007165	8.9	POMC, OXT, CRHBP, CRH, TRH, GNRH1
34	response to glucocorticoid stimulus	GO:051384	8.8	GHRHR, GHR, IL6, OXT
35	positive regulation of cell proliferation	GO:008284	8.7	AVP, FSHB, INS, IL6, IGF1, GHRH
36	positive regulation of transcription, DNA-dependent	GO:045893	8.7	POU1F1, SOX2, SRY, OTX2, GHRH, GLI2
37	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	PROP1, SOX15, SOX2, POMC, POU1F1, SIX3

Molecular functions related to hypopituitarism according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	10.3	GH1, PRL
2	growth hormone-releasing hormone activity	GO:016608	10.2	GHRL, GHRH
3	neurohypophyseal hormone activity	GO:005185	9.7	OXT, AVP
4	neuropeptide hormone activity	GO:005184	9.7	AVP, TRH, CRH
5	sequence-specific DNA binding	GO:043565	8.7	SIX3, POU1F1, SOX2, SOX14, HESX1, OTX2
6	hormone activity	GO:005179	8.5	GCG, POMC, PRL, CRH, SST, GH1
7	sequence-specific DNA binding transcription factor activity	GO:003700	8.3	PROP1, SOX1, SOX15, SOX2, SOX21, POU1F1