MCID: HYP083
MIFTS: 58

Hypopituitarism malady

Summaries for Hypopituitarism

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  the pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  these hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  symptoms of this condition vary and depend on which hormones are affected.  treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones. last updated: 7/20/2012

MalaCards: Hypopituitarism, also known as pituitary insufficiency nos, is related to diabetes insipidus and thyroiditis. An important gene associated with Hypopituitarism is SOX3 (SRY (sex determining region Y)-box 3), and among its related pathways are Mineralocorticoid biosynthesis and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and thyroid, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Wikipedia:63 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Aliases & Classifications for Hypopituitarism

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

hypopituitarism 8 42 10 44 60
pituitary insufficiency nos 8
pituitary insufficiency 42


External Ids:

Disease Ontology8 DOID:9406
MeSH34 D007018
NCIt39 C62591

Related Diseases for Hypopituitarism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypopituitarism family:

Familial Hypopituitarism

Diseases related to Hypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.7POMC, AQP2, GHRH, PRL, TRH
2thyroiditis30.5TRH, POMC
3adenoma30.5HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
4pituitary adenoma30.4PRL, PROP1, IGF1, TRH, POU1F1, POMC
5hypothyroidism30.4GHRL, SHBG, TRH
6pituitary apoplexy30.4GNRH1, PRL, TRH, POMC
7acromegaly30.3GH1, PRL, IGF1
8obesity30.3HSD11B1, HESX1, CRH, GHRL, GHRH, GH1
9septo-optic dysplasia30.2LHX3, HESX1, GH1, PROP1, POU1F1
10sheehan syndrome30.2CRH, PRL, IGF1, POMC
11hypoglycemia30.2GNRH1, CRH, GHRL, GHRH, GH1, PRL
12diabetes mellitus30.1HSD11B1, GHRL, GH1, SHBG, IGF1, POMC
13empty sella syndrome30.1POMC, TRH, PRL
14thyrotoxicosis30.0TRH
15congenital hypothyroidism30.0CYP21A2, POU1F1
16pituitary hypoplasia30.0LHX3, HESX1, SOX3, GHRH, PROP1, POU1F1
17craniopharyngioma30.0GH1, PRL, PROP1, IGF1, TRH, POMC
18hypogonadism30.0POMC, POU1F1, TRH, IGF1, SHBG, PROP1
19addison's disease29.9CRH, CRHBP, POMC, CYP21A2
20euthyroid sick syndrome29.9TRH
21chromophobe adenoma29.9GH1, PRL
22cushing's syndrome29.9POMC, GH1, CRH
23hypothalamic disease29.9PRL, GH1, CRH, GNRH1
24hypertension29.9POMC, IGF1, CRH, HSD11B1
25dwarfism29.9GHRH, GH1, PROP1, IGF1, POU1F1
26holoprosencephaly29.9LHX4, LHX3, HESX1, SOX3, PROP1, POU1F1
27turner syndrome29.9GH1, SHBG, IGF1, CYP21A2
28klinefelter's syndrome29.9GNRH1, PRL, PROP1, SHBG, TRH, CYP21A2
29panhypopituitarism29.9LHX4, LHX3, HESX1, GH1, PRL, PROP1
30hyperprolactinemia29.9GNRH1, CRH, GHRH, GH1, PRL, SHBG
31goiter29.7TRH
32dementia29.7TRH
33leiomyoma29.7GNRH1
34graves' disease29.7SHBG, CYP21A2
35pituitary cancer29.7PRL, POMC
36hyperthyroidism29.7GHRL, GHRH, GH1, PRL, SHBG, IGF1
37amenorrhea29.7GNRH1, CRH, PRL, SHBG, IGF1, TRH
38anorexia nervosa29.7CRH, GHRL, GHRH, GH1, PRL, SHBG
39adrenocortical carcinoma29.6POMC
40atherosclerosis29.6IGF1, SHBG, GHRL, HSD11B1
41anterior pituitary insufficiency, familial10.2
42cavernous sinus thrombosis10.1
43choroideremia hypopituitarism10.1
44mental retardation, x-linked, with isolated growth hormone deficiency10.1
45cerebritis10.0
46pallister-hall syndrome10.0
47functioning pituitary adenoma10.0
48hemorrhagic fever with renal syndrome10.0
49hydrocephalus10.0
50meningitis10.0

Graphical network of the top 20 diseases related to Hypopituitarism:



Diseases related to hypopituitarism

Clinical Features for Hypopituitarism

About this section

Drugs & Therapeutics for Hypopituitarism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hypopituitarism

Drug clinical trials:

Search ClinicalTrials for Hypopituitarism

Search NIH Clinical Center for Hypopituitarism

Search CenterWatch for Hypopituitarism

Genetic Tests for Hypopituitarism

About this section

Anatomical Context for Hypopituitarism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hypopituitarism:

32
Pituitary, Brain, Thyroid, Testes, Bone, Endothelial, Hypothalamus, B cells, Liver, Kidney, Lung, Heart, Uterus, Colon

Animal Models for Hypopituitarism or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2POU1F1, PROP1, GHRH, SOX3, HESX1, LHX3
2MP:000537510.0POMC, IGF1, GH1, GHRL, HSD11B1
3MP:00053899.6LHX3, GNRH1, SOX3, GHRH, GH1, PRL
4MP:00053709.6HSD11B1, GNRH1, GHRH, GH1, PRL, POMC
5MP:00053869.6HSD11B1, SOX3, CRH, CRHBP, GHRL, PRL
6MP:00036319.3SOX3, GNRH1, HESX1, LHX3, LHX4, HSD11B1
7MP:00053789.3CRHBP, CRH, SOX3, GNRH1, LHX3, HSD11B1
8MP:00053769.2GHRL, CRH, SOX3, GNRH1, LHX3, LHX4

Publications for Hypopituitarism

About this section
Sources:
50PubMed
See all sources

Articles related to Hypopituitarism:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
SIADH and partial hypopituitarism in a patient with intravascular large B-cell lymphoma: a rare cause of a common presentation. (23362070)
2013
2
Hypopituitarism in patients with vasculotoxic snake bite envenomation related acute kidney injury: a prospective study on the prevalence and outcomes of this complication. (23456212)
2013
3
Anterior hypopituitarism is rare and autoimmune disease is common in adults with idiopathic central diabetes insipidus. (22026638)
2012
4
An unusual case of dilated cardiomyopathy associated with partial hypopituitarism. (21713548)
2012
5
Gradual loss of ACTH due to a novel mutation in LHX4: comprehensive mutation screening in Japanese patients with congenital hypopituitarism. (23029363)
2012
6
Glucocorticoid replacement therapy is independently associated with reduced bone mineral density in women with hypopituitarism. (21767286)
2012
7
Hypopituitarism occurring in neonatal sepsis. (23426810)
2012
8
Partially reversible hypopituitarism in an adolescent with a rathke cleft cyst. (23926414)
2012
9
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
10
Pituitary gland: hypopituitarism can be avoided. (21332095)
2011
11
Hypopituitarism--a late consequence of aneurysmal subarachnoid haemorrhage? (21355768)
2011
12
Risk factors and management of deep venous thrombosis in children following post-surgical hypopituitarism in craniopharyngioma. (21557464)
2011
13
Pituitary stem cell update and potential implications for treating hypopituitarism. (21493869)
2011
14
Hypopituitarism masquerading as Prasad's syndrome: a case report. (22389997)
2011
15
Pituitary autoimmunity is associated with hypopituitarism in patients with primary empty sella. (21623153)
2011
16
Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. (20174891)
2010
17
Prevalence, natural history and consequences of posttraumatic hypopituitarism: a case for endocrine surveillance. (20158347)
2010
18
Visual vignette. Hypopituitarism and central diabetes insipidus due to an intracranial tumor (germinoma). (20150022)
2010
19
The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index. (19226261)
2009
20
High-risk pregnancy management in women with hypopituitarism. (19177043)
2009
21
Absence of SIX3 mutations in patients with congenital hypopituitarism. (19921650)
2009
22
Diagnosing unsuspected hypopituitarism in adults from suggestive thyroid function test results. (18275677)
2008
23
Problems typical for patients with hypopituitarism - a case presentation]. (18577349)
2008
24
Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone. (17311545)
2007
25
Effects of testosterone therapy on cardiovascular risk markers in androgen-deficient women with hypopituitarism. (17426086)
2007
26
Preliminary development of the new individualized HDQoL questionnaire measuring quality of life in adult hypopituitarism. (16987112)
2006
27
A case of postpartum hypopituitarism accompanied by Cushing's syndrome as a result of an adrenocortical carcinoma. (15863951)
2005
28
Hypopituitarism is a common neuro-endocrine disease: how manage to inform the medical community. (16508705)
2005
29
Hypopituitarism as a late complication of hemorrhagic fever. (15888918)
2005
30
Hypopituitarism as a consequence of brain tumours and radiotherapy. (16508716)
2005
31
Optic nerve aplasia in an infant with congenital hypopituitarism and posterior pituitary ectopia. (14718312)
2004
32
Congenital hypopituitarism: when should transcription factor gene screenings be performed?]. (15105786)
2004
33
The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. (15579750)
2004
34
Rehabilitation and hypopituitarism after traumatic brain injury. (15135790)
2004
35
Comparisons of leptin, incretins and body composition in obese and lean patients with hypopituitarism and healthy individuals. (12519414)
2003
36
Rest-activity patterns in children with hypopituitarism. (12777591)
2003
37
Two cases of intravascular lymphomatosis disclosing with hypopituitarism. (12031934)
2002
38
Premature mortality and hypopituitarism. (11430385)
2001
39
Androgen deficiency in women with hypopituitarism. (11158009)
2001
40
Hypopituitarism after surgical clipping of a ruptured cerebral aneurysm. (11700429)
2001
41
Clinical review 113: Hypopituitarism secondary to head trauma. (10770165)
2000
42
Hypopituitarism due to lymphocytic hypophysitis in a patient with retroperitoneal fibrosis. (9519190)
1997
43
Abnormal development of the sella turcica and lack of pituitary visualization in a patient with partial hypopituitarism. (7594230)
1995
44
Serum growth hormone response to growth hormone-releasing hormone in non-obese and obese adults with hypopituitarism. (8510526)
1993
45
Hypopituitarism associated with Cogan's syndrome; high-dose glucocorticoid therapy reverses pituitary swelling. (1865589)
1991
46
Primary empty sella syndrome and hypopituitarism associated with primary hypothyroidism. (6792264)
1981
47
Serum prolactin during pregnancy induced by pituitary gonadotrophins in a patient with post partum hypopituitarism (Sheehan syndrome). (6788010)
1981
48
Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus, and postaxial polydactyly--a new syndrome? Part II: Neuropathological considerations. (7211954)
1980
49
Insulin deficiency associated with hypoglycemia and good glucose tolerance in hypopituitarism. Report of a case with acromegaly developing pituitary apoplexy. (4830062)
1974
50
The paradoxical effect on diuresis of posterior hypophyseal extracts with vasopressor and antidiuretic action in a case of serious hypoadrenalism secondary to hypopituitarism. (13689399)
1960

Genetic Variations for Hypopituitarism

About this section

Expression for genes affiliated with Hypopituitarism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypopituitarism

Search GEO for disease gene expression data for Hypopituitarism.

Pathways for genes affiliated with Hypopituitarism

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN, 29KEGG
See all sources

Compounds for genes affiliated with Hypopituitarism

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hypopituitarism according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CRHBP, TRH, HSD11B1
2forskolin44 49 1112.4POU1F1, GHRH, HSD11B1, CRH, POMC
311 deoxycortisol4410.3PRL, CYP21A2, POMC, SHBG, CRH
4fenfluramine28 44 1112.3TRH, CRH, GHRH, POMC, PRL
5oxandrolone44 1111.3GHRL, GH1, IGF1, SHBG
6acth 1-244410.3PRL, POMC, CYP21A2, CRH
7bromocriptine28 44 1112.3POU1F1, TRH, SHBG, PRL, GHRH, GNRH1
8cortisone44 2411.3HSD11B1, POMC, CRH, CYP21A2, GH1, IGF1
9ghrp4410.3GHRL, IGF1, PRL, TRH, GHRH, GH1
10leuprolide acetate4410.2GNRH1, GH1, PRL, CYP21A2, IGF1, SHBG
11norepinephrine44 11 2412.2CYP21A2, POMC, TRH, GHRH, GNRH1, PRL
12pyridostigmine44 1111.2CRH, GHRL, GHRH, TRH, IGF1, PRL
13spironolactone49 44 59 28 1114.2POMC, CYP21A2, CRH, GNRH1, SHBG
14naltrexone44 49 28 1113.2GNRH1, CRH, POMC, IGF1, PRL, GH1
1517-hydroxyprogesterone44 2411.2SHBG, CYP21A2, POMC, PRL, GNRH1, CRH
16hexarelin44 2811.2POMC, IGF1, PRL, GH1, GHRH, GHRL
17clonidine44 28 1112.2GHRH, TRH, POMC, GH1, PRL, IGF1
18clomiphene citrate4410.2CYP21A2, IGF1, SHBG, PRL, GH1, CRH
19opiate4410.2CRH, GNRH1, GH1, PRL, GHRH, POMC
20metformin44 49 1112.2IGF1, GNRH1, GH1, SHBG, POMC, GHRL
21allopregnanolone4410.1POMC, GNRH1, CRH, SHBG
22corticosterone44 59 2412.1CRH, PRL, POMC, CYP21A2, GHRL, HSD11B1
2311beta-hydroxysteroid4410.1POMC, GH1, CRH, HSD11B1, CYP21A2
24naloxone44 49 28 1113.1POMC, TRH, PRL, GH1, GNRH1, GHRH
25dopamine44 28 11 2413.1IGF1, GNRH1, CRH, TRH, SHBG, GHRL
26mifepristone44 59 28 1113.0HSD11B1, GNRH1, POMC, SHBG, PRL, CRH
27dhea4410.0CYP21A2, POMC, IGF1, SHBG, GH1, PRL
28androstenedione44 2411.0CYP21A2, CRH, GNRH1, HSD11B1, POMC, IGF1
29triiodothyronine4410.0GHRL, GHRH, GH1, PRL, SHBG, IGF1
30dehydroepiandrosterone sulfate4410.0CYP21A2, POMC, IGF1, GNRH1, CRH, GHRL
31octreotide44 59 28 1113.0POMC, TRH, GNRH1, CRH, GHRL, GHRH
32epinephrine44 11 2412.0CRH, GNRH1, AQP2, POMC, CYP21A2, GHRL
33alanine449.9GH1, SHBG, CRH, POU1F1, POMC, AQP2
34cocaine44 1110.9GNRH1, POMC, TRH, PRL, GHRL, CRH
35adenylate449.9POMC, SHBG, GHRH, GNRH1, CRH, GH1
36ribonucleic acid449.8IGF1, POU1F1, POMC, CYP21A2, PRL, GH1
37thyroxine44 2410.8CRH, GHRL, GHRH, GH1, PRL, SHBG
38vitamin d449.8CRH, GHRH, SHBG, IGF1, POU1F1, GHRL
39dihydrotestosterone44 28 11 2412.8IGF1, PRL, GH1, GNRH1, CYP21A2, SHBG
40hydrocortisone44 2 59 1112.7POMC, CYP21A2, AQP2, TRH, IGF1, HSD11B1
41steroid449.7POU1F1, CYP21A2, AQP2, IGF1, POMC, CRH
42glucose449.7TRH, CYP21A2, HSD11B1, GHRL, GHRH, PRL
43testosterone44 59 11 2412.7HSD11B1, GNRH1, CRH, GHRL, GHRH, GH1
44estradiol44 11 2411.6HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
45arginine449.6POMC, CYP21A2, AQP2, PRL, SHBG, POU1F1
46gnrh449.6CYP21A2, POMC, TRH, IGF1, LHX3, HESX1
47progesterone44 59 28 11 2413.6IGF1, TRH, POU1F1, POMC, CYP21A2, AQP2
48acth449.5HSD11B1, CRH, GNRH1, HESX1, CYP21A2, POMC
49dexamethasone44 49 28 1112.4HSD11B1, GNRH1, CRH, CRHBP, GHRL, GHRH
50creatinine449.4SHBG, IGF1, GH1, AQP2, GHRL, POMC

GO Terms for genes affiliated with Hypopituitarism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.3POMC, GHRL
2varicosityGO:04319610.0CRHBP, CRH
3secretory granuleGO:03014110.0CRHBP, PRL, TRH, POMC
4extracellular spaceGO:0056159.7GNRH1, CRH, CRHBP, GHRL, GHRH, GH1
5extracellular regionGO:0055769.6POMC, GNRH1, CRH, GHRL, GHRH, GH1

Biological processes related to Hypopituitarism according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1medial motor column neuron differentiationGO:02152610.6LHX4, LHX3
2cellular response to cocaineGO:07131410.6CRH, CRHBP
3positive regulation of cortisol secretionGO:05146410.6CRH, GHRL
4negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.6CRH, GHRL
5positive regulation of growth hormone secretionGO:06012410.5GHRL, GHRH
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.5GHRH, GH1, IGF1
7positive regulation of corticotropin secretionGO:05146110.5GHRL, CRH
8glucocorticoid biosynthetic processGO:00670410.5CYP21A2, CRH, HSD11B1
9ovulation cycleGO:04269810.5GNRH1, PRL
10growth hormone secretionGO:03025210.5GHRL, GHRH
11positive regulation of multicellular organism growthGO:04001810.5GHRL, GHRH, GH1, POU1F1
12parturitionGO:00756710.5CRH, PRL
13hormone-mediated signaling pathwayGO:00975510.4TRH, GHRL, CRHBP
14response to ethanolGO:04547110.4GNRH1, CRH, PRL, TRH
15female pregnancyGO:00756510.3AQP2, PRL, CRHBP, CRH, GNRH1
16synaptic transmission, dopaminergicGO:00196310.3CRHBP, CRH
17positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1
18regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.3CRHBP, CRH
19negative regulation of apoptotic processGO:04306610.2PROP1, GHRL, GNRH1, LHX3, LHX4
20cell-cell signalingGO:00726710.2POMC, TRH, GHRH, GNRH1
21organ morphogenesisGO:00988710.2LHX4, LHX3, SOX3
22hypothalamus developmentGO:02185410.0CRH, SOX3
23signal transductionGO:00716510.0GNRH1, CRH, CRHBP, IGF1, TRH, POMC

Molecular functions related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.3PRL, GH1
2growth hormone-releasing hormone activityGO:01660810.0GHRH, GHRL
3hormone activityGO:0051799.8POMC, GNRH1, CRH, GH1, PRL, IGF1

Products for genes affiliated with Hypopituitarism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypopituitarism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet