MCID: HYP083
MIFTS: 53

Hypopituitarism malady

Genetic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Hypopituitarism

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NIH Rare Diseases:42 Hypopituitarism occurs when the body has low levels of certain hormones made by the pituitary gland.  the pituitary gland normally makes several hormones (including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone, vasopressin, and oxytocin).  these hormones are important for directing body growth and development, and for regulating blood pressure and metabolism.  symptoms of this condition vary and depend on which hormones are affected.  treatment depends on the cause of this condition; once the cause is corrected, medication (hormone replacement therapy) must be taken to provide the body with the normal amount of hormones. last updated: 7/20/2012

MalaCards based summary: Hypopituitarism, also known as pituitary insufficiency, is related to adenoma and obesity. An important gene associated with Hypopituitarism is PROP1 (PROP paired-like homeobox 1). The compounds bromocriptine and steroid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and thyroid, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Wikipedia:65 Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Aliases & Classifications for Hypopituitarism

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Hypopituitarism, Aliases & Descriptions:

Name: Hypopituitarism 8 42 10 44 62
Pituitary Insufficiency 42 62
 
Pituitary Insufficiency Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:9406
NCIt39 C62591
MeSH34 D007018

Related Diseases for Hypopituitarism

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Diseases in the Hypopituitarism family:

Familial Hypopituitarism

Diseases related to Hypopituitarism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.2GHRH, PROP1, POU1F1
2obesity30.2HESX1, PROP1, GHRH
3pituitary adenoma30.1GHRH, PROP1, POU1F1
4septo-optic dysplasia30.1LHX3, POU1F1, HESX1, PROP1
5growth hormone deficiency29.9SOX3, POU1F1, HESX1, PROP1, GHRH
6empty sella syndrome29.8LHX3, POU1F1, PROP1
7hypogonadism29.8PROP1, POU1F1
8acth deficiency29.8POU1F1, HESX1, PROP1
9dwarfism29.7GHRH, PROP1, POU1F1
10hypothyroidism29.6GHRH, PROP1, HESX1, POU1F1, LHX3
11panhypopituitarism29.1LHX3, PROP1, HESX1, POU1F1, LHX4
12short stature28.8LHX4, POU1F1, HESX1, PROP1, GHRH
13holoprosencephaly28.8PROP1, HESX1, POU1F1, SOX3, LHX4, LHX3
14pituitary hypoplasia28.6LHX3, LHX4, SOX3, GHRH, PROP1, HESX1
15brain injury10.7
16traumatic brain injury10.7
17diabetes insipidus10.5
18aneurysm10.5
19thyroiditis10.4
20lymphocytic hypophysitis10.4
21optic nerve hypoplasia10.4
22pituitary apoplexy10.3
23acromegaly10.3
24familial hypopituitarism10.3
25anterior pituitary insufficiency, familial10.3
26sheehan syndrome10.2
27choroideremia hypopituitarism10.2
28hypoglycemia10.2
29cavernous sinus thrombosis10.2
30endotheliitis10.2
31diabetes mellitus10.2
32ectodermal dysplasia10.2
33anophthalmia - hypothalamo-pituitary insufficiency10.2
34germinoma10.1
35cerebritis10.1
36corpus callosum dysgenesis hypopituitarism10.1
37gigantism10.1
38granulomatous hypophysitis10.1
39hemorrhagic fever10.1
40kaplowitz bodurtha syndrome10.1
41head injury10.1
42b-cell lymphomas10.1
43pallister-hall syndrome10.1
44craniopharyngioma10.1
45functioning pituitary adenoma10.1
46hemorrhagic fever with renal syndrome10.1
47meningitis10.1
48thyrotoxicosis10.1
49arthrogryposis, distal, with hypopituitarism, mental retardation, and facial anomalies10.1
50hypoadrenalism10.1

Graphical network of the top 20 diseases related to Hypopituitarism:



Diseases related to hypopituitarism

Symptoms for Hypopituitarism

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Drugs & Therapeutics for Hypopituitarism

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Drug clinical trials:

Search ClinicalTrials for Hypopituitarism

Search NIH Clinical Center for Hypopituitarism

Genetic Tests for Hypopituitarism

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Anatomical Context for Hypopituitarism

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MalaCards organs/tissues related to Hypopituitarism:

32
Pituitary, Brain, Thyroid, Testes, Bone, Endothelial, Hypothalamus, Liver, B cells, Heart, Kidney, Lung, Colon, Uterus

Animal Models for Hypopituitarism or affiliated genes

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MGI Mouse Phenotypes related to Hypopituitarism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7HESX1, POU1F1, LHX3
2MP:00053828.2LHX3, SOX3, POU1F1, HESX1
3MP:00053897.8LHX3, SOX3, POU1F1, PROP1, GHRH
4MP:00053787.5LHX3, SOX3, POU1F1, PROP1, GHRH
5MP:00107687.3LHX3, LHX4, SOX3, POU1F1, HESX1, PROP1
6MP:00053767.3LHX3, LHX4, SOX3, POU1F1, PROP1, GHRH
7MP:00053796.9GHRH, LHX3, LHX4, SOX3, POU1F1, HESX1
8MP:00036316.9LHX3, LHX4, SOX3, POU1F1, HESX1, PROP1

Publications for Hypopituitarism

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Articles related to Hypopituitarism:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Chronic hypopituitarism is uncommon in survivors of aneurysmal subarachnoid haemorrhage. (24965315)
2014
2
Sudden cardiac death as a result of neglected hypopituitarism. (23825983)
2013
3
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
4
Measurement of oxidative stress and endothelial dysfunction in patients with hypopituitarism and severe deficiency adult growth hormone deficiency. (22228310)
2012
5
Hypopituitarism due to primary empty sella and uncommon muscular symptoms. (21258802)
2012
6
Sturge-Weber syndrome: presentation with partial hypopituitarism. (23155711)
2012
7
Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. (22246489)
2012
8
Pathophysiology of hypopituitarism in the setting of brain injury. (18481181)
2012
9
Anterior hypopituitarism is rare and autoimmune disease is common in adults with idiopathic central diabetes insipidus. (22026638)
2012
10
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
11
Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism. (21521324)
2011
12
Hypopituitarism as unusual sequelae to central nervous system tuberculosis. (22029037)
2011
13
Increased transactivation associated with SOX3 polyalanine tract deletion in a patient with hypopituitarism. (21289259)
2011
14
A giant aneurysm of internal carotid artery causing hypopituitarism. (20636831)
2010
15
Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. (20174891)
2010
16
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
17
Prevalence, natural history and consequences of posttraumatic hypopituitarism: a case for endocrine surveillance. (20158347)
2010
18
Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up. (20501686)
2010
19
Hypopituitarism following traumatic brain injury: prevalence is affected by the use of different dynamic tests and different normal values. (19783619)
2010
20
All patients with 'idiopathic' hypopituitarism should be screened for hemochromatosis. (18270843)
2009
21
Hyperthyroidism unmasked several years after the medical and radiosurgical treatment of an invasive macroprolactinoma inducing hypopituitarism: a case report. (19829805)
2009
22
Congenital hypopituitarism: clinico-radiological correlation. (20020580)
2009
23
Prevalence of hypopituitarism in patients with cerebrovascular diseases. (19020380)
2008
24
Female sexual dysfunction in hypopituitarism. (17765514)
2007
25
Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation. (17127446)
2007
26
Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated? (17551481)
2007
27
Untreated hypopituitarism due to absence of the pituitary stalk with normal adult height: report of two cases. (16622308)
2006
28
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. (16144947)
2005
29
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
30
Neonatal hypopituitarism presenting with poor feeding, hypoglycemia and prolonged unconjugated hyperbilirubinemia. (15512725)
2004
31
Optic nerve aplasia in an infant with congenital hypopituitarism and posterior pituitary ectopia. (14718312)
2004
32
The spectrum of hypopituitarism caused by PROP1 mutations. (12464226)
2002
33
Postpartum thyroiditis or hypopituitarism? (12240872)
2002
34
Survival with hypopituitarism from congenital syphilis. (11927736)
2002
35
Spontaneous thrombosis of a giant internal carotid aneurysm in a patient who presented with hypopituitarism. (12617242)
2002
36
The "quality of life-assessment of growth hormone deficiency in adults" questionnaire: can it be used to assess quality of life in hypopituitarism? (11344182)
2001
37
Premature mortality and hypopituitarism. (11430385)
2001
38
The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months. (11701703)
2001
39
Rheumatoid factor positive hypertrophic cranial pachymeningitis in association with hypopituitarism and multiple cranial nerve palsies. (11579967)
2001
40
Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism. (10931083)
2000
41
MR imaging in children with ectopic pituitary gland and anterior hypopituitarism. (10734341)
1999
42
Hydrocortisone replacement therapy in children and adolescents with hypopituitarism. (9302370)
1997
43
Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. (8881449)
1996
44
Peripartum hypopituitarism and lymphocytic hypophysitis. (7648244)
1995
45
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
46
Comparison of growth and somatomedin C responses following growth hormone treatment in children with small-for-date short stature, significant idiopathic short stature and hypopituitarism. (6539552)
1984
47
Hypothalamic hypopituitarism. A case of panhypopituitarism with TSH and LH deficiency of hypothalamic origin. (4196985)
1973
48
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
49
Essential hypernatremia, absence of thirst, hypopituitarism, and hypothalamic destruction due to a dysgerminoma. (4679411)
1972
50
An endobronchial chondroma in a cachectic psychotic with hypopituitarism. (13253916)
1955

Variations for Hypopituitarism

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Expression for genes affiliated with Hypopituitarism

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Expression patterns in normal tissues for genes affiliated with Hypopituitarism

Search GEO for disease gene expression data for Hypopituitarism.

Pathways for genes affiliated with Hypopituitarism

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Compounds for genes affiliated with Hypopituitarism

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Hypopituitarism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromocriptine44 28 1110.8GHRH, POU1F1
2steroid448.8GHRH, PROP1, POU1F1
3gnrh448.5LHX3, HESX1, PROP1, GHRH
4acth448.3GHRH, PROP1, HESX1, POU1F1

GO Terms for genes affiliated with Hypopituitarism

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Cellular components related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.6PROP1, LHX3
2nucleusGO:0056347.0PROP1, HESX1, POU1F1, SOX3, LHX4, LHX3

Biological processes related to Hypopituitarism according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1pituitary gland developmentGO:0219839.6SOX3, LHX3
2medial motor column neuron differentiationGO:0215269.5LHX4, LHX3
3motor neuron axon guidanceGO:0080459.5LHX3, LHX4
4central nervous system developmentGO:0074179.3PROP1, SOX3
5placenta developmentGO:0018909.3LHX4, LHX3
6positive regulation of multicellular organism growthGO:0400189.2POU1F1, GHRH
7organ morphogenesisGO:0098879.1SOX3, LHX4, LHX3
8negative regulation of apoptotic processGO:0430668.9LHX3, LHX4, PROP1
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.8PROP1, POU1F1, LHX3

Molecular functions related to Hypopituitarism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.7PROP1, HESX1
2chromatin bindingGO:0036828.6PROP1, HESX1, POU1F1
3sequence-specific DNA bindingGO:0435658.0LHX3, LHX4, POU1F1, HESX1
4sequence-specific DNA binding transcription factor activityGO:0037007.7PROP1, HESX1, POU1F1, LHX4, LHX3

Products for genes affiliated with Hypopituitarism

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Sources for Hypopituitarism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet