HLHS
MCID: HYP055
MIFTS: 61

Hypoplastic Left Heart Syndrome (HLHS) malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Hypoplastic Left Heart Syndrome

About this section
Sources:
11Disease Ontology, 13DISEASES, 24GeneTests, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 35LifeMap Discovery®, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hypoplastic Left Heart Syndrome:

Name: Hypoplastic Left Heart Syndrome 35 11 48 24 54 39 13 68
Hlhs 48 54
 
Hypoplastic Left Heart 27

Characteristics:

Orphanet epidemiological data:

54
hypoplastic left heart syndrome:
Prevalence: 1-5/10000 (Europe),1-5/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),1-5/10000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),1-5/10000 (Hungary),1-5/10000 (Ireland),1-9/100000 (Italy),1-5/10000 (Malta),1-9/100000 (Netherlands),1-5/10000 (Norway),1-9/100000 (Poland),1-9/100000 (Portugal),1-5/10000 (Switzerland),1-5/10000 (United Kingdom),1-5/10000 (Ukraine),1-9/100000 (Spain); Age of onset: Antenatal,Neonatal

Classifications:



External Ids:

Disease Ontology11 DOID:9955
ICD1030 Q23.4
ICD9CM32 746.7
MeSH39 D018636
NCIt45 C98894
SNOMED-CT62 62067003
Orphanet54 ORPHA2248
MESH via Orphanet40 D018636
UMLS via Orphanet69 C0152101
ICD10 via Orphanet31 Q23.4

Summaries for Hypoplastic Left Heart Syndrome

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NIH Rare Diseases:48 Hypoplastic left heart syndrome (hlhs) is a problem with the heart’s structure that is present at birth (congenital). it occurs when parts of the left side of the heart (mitral valve, left ventricle, aortic valve, and aorta) do not develop completely. the underdeveloped left side of the heart is unable to provide enough blood flow to the body, which decreases the oxygen-rich blood supply. babies with hlhs might look normal at birth, but will develop symptoms of hlhs within a few days. these symptoms might include: poor feeding, problems breathing, pounding heart, weak pulse, and ashen or bluish skin color. the cause of hlhs is presently unknown. last updated: 7/21/2011

MalaCards based summary: Hypoplastic Left Heart Syndrome, also known as HLHS, is related to sudden infant death syndrome and hypoplastic left heart syndrome 2, and has symptoms including Array, Array and Array. An important gene associated with Hypoplastic Left Heart Syndrome is GJA1 (Gap Junction Protein Alpha 1), and among its related pathways are HOP Signaling and Cardiac Progenitor Differentiation. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are craniofacial and respiratory system.

Disease Ontology:11 A congenital heart disease characterized by abnormal development of the left-sided structures of the heart.

Wikipedia:71 Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect in which the left heart is... more...

Related Diseases for Hypoplastic Left Heart Syndrome

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Diseases in the Hypoplastic Left Heart Syndrome family:

Hypoplastic Left Heart Syndrome 2 Hypoplastic Left Heart Syndrome 1

Diseases related to Hypoplastic Left Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1sudden infant death syndrome29.8CDH2, GJA1, NKX2-5
2hypoplastic left heart syndrome 212.4
3hypoplastic left heart syndrome 112.4
4hemophagocytic lymphohistiocytosis11.9
5left ventricular outflow tract obstruction11.4
6griscelli syndrome, type 211.2
7aortic valve disease 111.1
8ventricular septal defect 310.9
9aortic valve disease 210.9
10hypoplastic right heart syndrome10.9
11hemophagocytic lymphohistiocytosis, familial, 110.7
12lymphoproliferative syndrome, x-linked, 110.7
13pyloric stenosis, infantile hypertrophic, 510.2FOXC2, FOXL1
14metaphyseal enchondromatosis with d-2-hydroxyglutaric aciduria10.2FOXC2, FOXL1
15immunodeficiency 41 with lymphoproliferation and autoimmunity10.2EHMT1, NOTCH1
16congenital generalized lipodystrophy10.2FOXC2, FOXL1
17cerebritis10.2
18usher syndrome, type ik10.1EHMT1, NOTCH1
19aneurysm10.1
20macroglossia10.1NKX2-5, NPPB
21right aortic arch10.1
22emery-dreifuss muscular dystrophy 7, ad10.1CDH2, NKX2-5
23deafness, autosomal recessive 7910.1NOTCH1, NPPB, TNNI3
24hereditary late-onset parkinson disease10.1NOTCH1, SMAD6
25inferolateral myocardial infarct10.0NPPA, NPPB
26heart disease10.0
27cor triatriatum10.0
28transposition of the great arteries10.0
29interatrial communication10.0
30mental retardation, truncal obesity, retinal dystrophy, and micropenis10.0EHMT1, NOTCH1
31malignant pineal area germ cell neoplasm10.0GATA5, NKX2-5, NPPB
32histidine metabolism disease9.9LEP, NPPA, NPPB
33adult t-cell leukemia9.9NPPA, NPPB, TNNI3
34fetal alcohol syndrome9.9GATA5, NKX2-5, NPPA
35holt-oram syndrome9.9
36pagod syndrome9.9
37endocardial fibroelastosis9.9
38omphalocele9.9
39microcephaly9.9
40turner syndrome9.9
41pulmonary valve stenosis9.9
42pentalogy of cantrell9.9
43cdkl5-related angelman-like syndrome9.8CDH2, GJA1, NPPB, TNNI3
44ceroid lipofuscinosis, neuronal, kufs type, adult onset9.8NPPA, NPPB, SMAD6
45myocardial infarction9.7
46coronary artery disease9.7
47wolf-hirschhorn syndrome9.7
48kleefstra syndrome9.7
49jacobsen syndrome9.7
50moebius syndrome9.7

Graphical network of the top 20 diseases related to Hypoplastic Left Heart Syndrome:



Diseases related to hypoplastic left heart syndrome

Symptoms & Phenotypes for Hypoplastic Left Heart Syndrome

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Human phenotypes related to Hypoplastic Left Heart Syndrome:

 54 64 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 patent ductus arteriosus64 54 Occasional (29-5%) HP:0001643
2 mitral stenosis64 54 Occasional (29-5%) HP:0001718
3 maternal diabetes64 54 Occasional (29-5%) HP:0009800
4 hypoplastic aortic arch64 54 Frequent (79-30%) HP:0012304
5 atria septal defect54 Occasional (29-5%)
6 abnormality of chromosome segregation64 54 Occasional (29-5%) HP:0002916
7 hypoplastic left heart64 54 Very frequent (99-80%) HP:0004383
8 mitral atresia64 54 Occasional (29-5%) HP:0011560
9 atrial septal defect64 HP:0001631

MGI Mouse Phenotypes related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.7EHMT1, FOXC2, GJA1, HAND1, NKX2-5, NOTCH1
2MP:00053889.2FOXC2, GJA1, HAND1, LEP, NKX2-5, NOTCH1
3MP:00053819.1FOXC2, FOXL1, GATA5, HAND1, LEP, NKX2-5
4MP:00053808.9CDH2, EHMT1, FOXC2, GJA1, HAND1, LEP
5MP:00053798.8FOXL1, GATA5, GJA1, LEP, NKX2-5, NOTCH1
6MP:00053678.6FOXC2, GATA5, LEP, NOTCH1, NPPA, XDH
7MP:00053908.1EHMT1, FOXC2, GATA5, GJA1, HAND1, LEP
8MP:00053788.0CDH2, EHMT1, FOXC2, FOXL1, GJA1, HAND1
9MP:00053847.8CDH2, EHMT1, FOXL1, GATA5, GJA1, HAND1
10MP:00053766.7CDH2, FOXC2, GATA5, GJA1, HAND1, LEP
11MP:00053856.7CDH2, EHMT1, FOXC2, GATA5, GJA1, HAND1
12MP:00053696.4CDH2, FOXC2, GATA5, GJA1, HAND1, LEP
13MP:00107686.3CDH2, EHMT1, FOXC2, FOXL1, GATA5, GJA1

Drugs & Therapeutics for Hypoplastic Left Heart Syndrome

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Drugs for Hypoplastic Left Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bosentanapproved, investigationalPhase 2104147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
DB00559
 
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentan
bosentanum
bosentán
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
2
MilrinoneapprovedPhase 23578415-72-24197
Synonyms:
-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4&prime
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
111GE027
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
78415-72-2
AB00514027
AC-4730
AC1L1HMP
AC1Q2EBX
BIDD:GT0197
BPBio1_001156
BRN 3546821
BSPBio_001050
C07224
C12H9N3O
CAS-78415-72-2
CCRIS 3795
CHEBI:50693
CHEMBL189
CID4197
CPD000058475
Corotrop
Corotrope
D00417
DB00235
EINECS 278-903-6
EN002063
EU-0100737
HMS1571E12
HMS2051L10
HMS2090J14
I06-0259
LS-44610
Lopac-M-4659
Lopac0_000737
 
M 4659
M1663
M4659_SIGMA
MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER
MLS000028818
MLS001424052
Milrila
Milrila (TN)
Milrinona
Milrinona [Spanish]
Milrinone
Milrinone (JAN/USAN/INN)
Milrinone Lactate
Milrinone [USAN:BAN:INN]
Milrinonum
Milrinonum [Latin]
NCGC00015675-01
NCGC00015675-02
NCGC00015675-04
NCGC00015675-07
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00164390-01
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Primacor
S2484_Selleck
SAM001246611
SBB055743
SMR000058475
SPBio_002965
Tocris-1504
UNII-JU9YAX04C7
WIN 47203-2
Win-47203
Win-47203-2
YM 018
ZINC09224016
milrinone
3Protective AgentsPhase 27443
4AnestheticsPhase 29596
5Neurotransmitter AgentsPhase 2, Phase 118340
6Adrenergic AgentsPhase 2, Phase 15352
7Endothelin Receptor AntagonistsPhase 2218
8Vasodilator AgentsPhase 2, Phase 13543
9Sildenafil CitratePhase 2, Phase 1331171599-83-0
10Phosphodiesterase InhibitorsPhase 2, Phase 11289
11Phosphodiesterase 5 InhibitorsPhase 2, Phase 1589
12Antihypertensive AgentsPhase 24207
13HematinicsPhase 1, Phase 21684
14Epoetin alfaPhase 1, Phase 2658113427-24-0
15Phosphodiesterase 3 InhibitorsPhase 2133
16Platelet Aggregation InhibitorsPhase 22516
17
Citric Acidnutraceutical, vet_approvedPhase 2, Phase 1116077-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
18CitrateNutraceuticalPhase 2, Phase 11160
19
Dexmedetomidineapproved, vet_approvedPhase 159276631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
20Adrenergic AgonistsPhase 13027
21Hypnotics and SedativesPhase 12616
22Adrenergic alpha-2 Receptor AgonistsPhase 1980
23Central Nervous System DepressantsPhase 113403
24Peripheral Nervous System AgentsPhase 123689
25Adrenergic alpha-AgonistsPhase 11734
26AnalgesicsPhase 111733
27Analgesics, Non-NarcoticPhase 16501
28
Bupropionapproved32934841-39-9, 34911-55-2444
Synonyms:
( -)-2-(tert-Butylamino)-3'-chloropropiophenone
( -)-2-(tert-Butylamino)-3'-chlorpropiophenon
(+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
(+-)-Bupropion
.alpha.-(tert-Butylamino)-m-chloropropiophenone
1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one
2-(Tert-Butylamino)-3'-chloropropiophenone
2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
34841-36-6 (hydrochloride)
34841-39-9
34911-55-2
AB00053756
AC-197
AC1L198Y
AMFEBUTAMONE HCl
Amfebutamon
Amfebutamona
Amfebutamona [INN-Spanish]
Amfebutamone
Amfebutamonum
Amfebutamonum [INN-Latin]
BPBio1_000042
BRD-A05186015-003-05-7
BRN 2101062
BSPBio_000038
BSPBio_002247
Bupropion (INN)
Bupropion (Old RN)
Bupropion (USAN)
Bupropion Hcl
Bupropion SR
Bupropion [INN:BAN]
Bupropion hydrocloride
C06860
CHEBI:3219
CHEMBL894
CID444
CPD000472526
D07591
DB01156
DivK1c_007050
Elont
 
HMS2051G10
HMS2089G14
Jsp006301
KBio1_001994
KBio2_002143
KBio2_004711
KBio2_007279
KBio3_001467
KBioGR_001168
KBioSS_002143
L000725
LS-122817
Lopac0_000166
MLS001424015
MolPort-003-845-432
NCGC00015122-06
NCGC00089751-02
NCI60_002714
NSC315851
Prestwick0_000249
Prestwick1_000249
Prestwick2_000249
Prestwick3_000249
SAM001246699
SMR000472526
SPBio_001817
SPBio_002257
SpecPlus_000954
Spectrum2_001659
Spectrum3_000644
Spectrum4_000614
Spectrum5_001406
Spectrum_001663
TL8002604
UNII-01ZG3TPX31
Wellbatrin
Wellbutrin
Wellbutrin SR
Wellbutrin XL
Zyban
alpha-(tert-butylamino)-m-chloropropiophenone
amfebutamonum
bupropion
29
Ethanolapproved213764-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
30
Dopamineapproved383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
31
Caffeineapproved, Nutraceutical39658-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
32
Vitamin Capproved, nutraceutical53150-81-75785, 54670067
Synonyms:
(+)-Sodium L-ascorbate
(+)-ascorbate
(+)-ascorbic acid
(2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one
(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one
(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one
129940-97-2
134-03-2 (monosodium salt)
14536-17-5
154170-90-8
2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one
255564_SIAL
259133-78-3
3-Keto-L-gulofuranolactone
3-Oxo-L-gulofuranolactone
3-Oxo-L-gulofuranolactone (enol form)
30208-61-8
33034_RIEDEL
33034_SIAL
47863_SUPELCO
47A605F0-4187-47A8-B0CE-F9E7DA1B0076
50-81-7
50976-75-5
56172-55-5
56533-05-2
57304-74-2
57606-40-3
623158-95-2
6730-29-6
882690-91-7
884381-69-5
885512-24-3
88845-26-5
89924-69-6
95209_FLUKA
95209_SIGMA
95210_FLUKA
95210_SIAL
95212_FLUKA
A0278_SIGMA
A0537
A2174_SIGMA
A2218_SIGMA
A2343_SIGMA
A4403_SIGMA
A4544_SIGMA
A5960_SIGMA
A7506_SIGMA
A92902_ALDRICH
A92902_SIAL
AB00376923
AB1002440
AC1L1L4T
AC1Q77S6
AR-1J3435
Acid Ascorbic
Acide ascorbique
Acide ascorbique [INN-French]
Acido ascorbico
Acido ascorbico [INN-Spanish]
Acidum ascorbicum
Acidum ascorbicum [INN-Latin]
Acidum ascorbinicum
Adenex
Allercorb
Ambap36431-82-0
Antiscorbic vitamin
Antiscorbutic factor
Antiscorbutic vitamin
Arco-cee
Ascoltin
Ascoltin (TN)
Ascor-B.I.D.
Ascorb
Ascorbajen
Ascorbate
Ascorbic Acid
Ascorbic Acid, Monosodium Salt
Ascorbic acid
Ascorbic acid (JP15/USP/INN)
Ascorbic acid [BAN:INN:JAN]
Ascorbic acid [INN:BAN:JAN]
Ascorbicab
Ascorbicap
Ascorbicap (TN)
Ascorbicin
Ascorbin
Ascorbinsaeure
Ascorbinsäure
Ascorbutina
Ascorbyl radical
Ascorin
Ascorteal
Ascorvit
BPBio1_000363
BSPBio_000329
C-Level
C-Long
C-Quin
C-Span
C-Vimin
C00072
C6H8O6
CCRIS 57
CE-VI-Sol
CHEBI:29073
CHEMBL196
CID5785
Cantan
Cantaxin
Caswell No. 061B
Catavin C
Ce lent
Ce-Mi-Lin
Ce-mi-lin
Ce-vi-sol
Cebicure
Cebid
Cebion
Cebione
Cecon
Cee-Caps TD
Cee-Vite
Cee-caps TD
Cee-vite
Cegiolan
Ceglion
Ceklin
Celaskon
Celin
Cell C
Cemagyl
Cemill
Cenetone
Cenolate
Cereon
Cergona
Cescorbat
Cetamid
Cetane
Cetane-Caps TC
Cetane-Caps TD
Cetane-caps TC
Cetane-caps TD
Cetebe
Cetemican
Cevalin
 
Cevatine
Cevex
Cevi-Bid
Cevi-bid
Cevimin
Cevital
Cevitamate
Cevitamic acid
Cevitamin
Cevitan
Cevitex
Cewin
Chewcee
Ciamin
Cipca
Citriscorb
Citrovit
Colascor
Concemin
Cortalex
D00018
DB00126
Davitamon C
Dora-C-500
Duoscorb
EINECS 200-066-2
FEMA No. 2109
Ferancee
Ferrous ascorbate
HSDB 818
HiCee
Hicee
Hybrin
IDO-C
Ido-C
Iron(II) ascorbate
Iron-ascorbic acid complexes
Juvamine
Kangbingfeng
Kyselina askorbova
Kyselina askorbova [Czech]
L(+)-Ascorbate
L(+)-Ascorbic acid
L-(+)-Ascorbate
L-(+)-Ascorbic Acid
L-(+)-Ascorbic acid
L-(+)-ascorbic acid
L-3-Ketothreohexuronic acid lactone
L-3-ketothreohexuronic acid
L-Ascorbate
L-Ascorbic Acid
L-Ascorbic acid
L-Ascorbic acid, free radical form
L-Lyxoascorbate
L-Lyxoascorbic acid
L-Threo-ascorbic acid
L-Threoascorbic acid
L-Xyloascorbate
L-Xyloascorbic acid
L-ascorbate
L-threo-Hex-2-enonic acid, gamma-lactone
L-threo-ascorbic acid
L-threo-hex-2-enono-1,4-lactone
LS-145
Laroscorbine
Lemascorb
Liqui-Cee
Liqui-cee
MLS002153776
Magnesium Ascorbicum
Magnorbin
Meri-C
Meri-c
MolPort-001-792-501
Monodehydroascorbic acid
NCGC00091517-01
NCGC00091517-02
NCGC00164357-01
NCI-C54808
NSC 33832
Natrascorb
Natrascorb injectable
Oral Vitamin C
Planavit C
Prestwick3_000325
Proscorbin
Redoxon
Ribena
Ronotec 100
Rontex 100
Roscorbic
Rovimix C
SMR001233160
Scorbacid
Scorbu C
Scorbu-C
Secorbate
Semidehydroascorbate
Sodascorbate
Sodium Ascorbate (Ascorbic Acid)
Stuartinic
Suncoat VC 40
Sunkist
Testascorbic
Tolfrinic
UNII-PQ6CK8PD0R
VASC
Vicelat
Vicin
Vicomin C
Viforcit
Viscorin
Viscorin 100M
Vitace
Vitacee
Vitacimin
Vitacin
Vitamin C
Vitamin- C
Vitamin-?C
Vitamisin
Vitascorbol
W210901_ALDRICH
Xitix
acide ascorbique
acidum ascorbicum
acidum ascorbinicum
antiscorbic vita min
ascor-b.i.d
ascorbate
ascorbic acid
bmse000182
cee-caps td
cevibid
component of Cortalex
component of E and C-Level
component of Endoglobin Forte
component of Ferancee
gamma-Lactone L-threo-Hex-2-enonate
gamma-Lactone L-threo-Hex-2-enonic acid
l-ascorbic acid
l-threo-hex-1-eofuranos-3-ulose
nchembio.174-comp5
nchembio.89-comp1
nchembio.92-comp2
nchembio821-comp9
roscorbi c
vitamin C
ácido ascórbico
33Vitamins5282
34Psychotropic Drugs6430
35Trace Elements6001
36Neurotransmitter Uptake Inhibitors3521
37Micronutrients6001
38Antioxidants3050
39Cytochrome P-450 Enzyme Inhibitors3917
40Dopamine Uptake Inhibitors1331
41Antidepressive Agents2736
42Antidepressive Agents, Tricyclic304
43Antidepressive Agents, Second-Generation1311
44Cytochrome P-450 CYP2D6 Inhibitors727
45Dopamine Agents3836
46Antibodies6394
47Immunoglobulins6394
48CalamusNutraceutical459
49Kavanutraceutical1619000-38-8

Interventional clinical trials:

(show top 50)    (show all 55)
idNameStatusNCT IDPhase
1Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood ProcedureCompletedNCT01215240Phase 3
2Study of Triostat in Infants During Heart SurgeryCompletedNCT00027417Phase 3
3Positive Pressure Ventilation and Sternal Closure in HLHSRecruitingNCT02455713Phase 2, Phase 3
4Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)RecruitingNCT02781922Phase 3
5Sildenafil After the Fontan OperationCompletedNCT00507819Phase 2
6Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS)CompletedNCT01829750Phase 2
7Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.CompletedNCT01292551Phase 2
8Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart SyndromeRecruitingNCT01736956Phase 1, Phase 2
9Ambrisentan in Single VentricleRecruitingNCT02080637Phase 2
10Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
11Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left VentricleNot yet recruitingNCT03079401Phase 1, Phase 2
12Maternal Hyperoxygenation in Congenital Heart DiseaseNot yet recruitingNCT03136835Phase 1, Phase 2
13Milrinone in Congenital Diaphragmatic HerniaNot yet recruitingNCT02951130Phase 2
14Parenteral Phenoxybenzamine During Congenital Heart Disease SurgeryWithdrawnNCT00770705Phase 2
15Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle PhysiologyCompletedNCT01273857Phase 1
16Understanding Dexmedetomidine in Neonates After Open Heart SurgeryCompletedNCT00576381Phase 1
17Understanding Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryCompletedNCT00573066Phase 1
18Sildenafil in Single Ventricle PatientsCompletedNCT01169519Phase 1
19Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart SyndromeRecruitingNCT01883076Phase 1
20Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart SyndromeRecruitingNCT02398604Phase 1
21Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart SyndromeSuspendedNCT01445041Phase 1
22Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI TechniquesUnknown statusNCT01107990
23Comparison of Feeding Strategies for Hypoplastic Left Heart Syndrome InfantsCompletedNCT02657629
24Neurodevelopmental Outcomes in Hypoplastic Left Heart SyndromeCompletedNCT00399555
25Single Ventricle OutcomeCompletedNCT00308217
26Fluid Balance in Children Undergoing Fontan SurgeryCompletedNCT02306057
27Bupropion & Cardio Birth Defect (Slone)CompletedNCT01597661
28Biomarker Study for Heart Failure in Children With Single Ventricle PhysiologyCompletedNCT00571233
29NIRS in Neonatal Cardiac SurgeryCompletedNCT00166101
30Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated PatientsCompletedNCT00974025
31Cerebral Perfusion During Neonatal Cardiac SurgeryCompletedNCT01032876
32Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle PhysiologyCompletedNCT02462434
33Quality of Life Among Children With Congenital Heart DiseaseCompletedNCT01202916
34Association Between a Mother's Exposure to "Strep Throat" and Her Baby's Developing Heart DiseaseCompletedNCT01603732
35Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental OutcomeCompletedNCT00713635
36A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical PalliationRecruitingNCT01708863
37Umbilical Cord Blood Collection and Processing for Cardiac Regeneration in Hypoplastic Left Heart Syndrome PatientsRecruitingNCT01856049
38SVRII Family Factors StudyRecruitingNCT01582529
39Cerebral Anatomy, Hemodynamics and MetabolismRecruitingNCT02919956
40Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)RecruitingNCT02184169
41Genetic Determinants of Congenital Heart Disease OutcomesRecruitingNCT01656941
42Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a NewbornActive, not recruitingNCT00734643
43Near-infrared Spectroscopy (NIRS) Neurodevelopmental OutcomesActive, not recruitingNCT00464100
44Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart SyndromeActive, not recruitingNCT01135485
45Diffuse Myocardial Fibrosis in Fontan PatientsActive, not recruitingNCT01929174
46Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical ReconstructionActive, not recruitingNCT02135081
47Long-term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt TypeEnrolling by invitationNCT02455531
48National Collaborative to Improve Care of Children With Complex Congenital Heart DiseaseEnrolling by invitationNCT02852031
49Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart DiseaseEnrolling by invitationNCT03147014
50SVR III: Brain Connectome and Neurodevelopmental OutcomesEnrolling by invitationNCT02692443

Search NIH Clinical Center for Hypoplastic Left Heart Syndrome

Inferred drug relations via UMLS68/NDF-RT46:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hypoplastic Left Heart Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hypoplastic Left Heart Syndrome:
Cardiac progenitor cells for single-ventricle anomalies
Embryonic/Adult Cultured Cells Related to Hypoplastic Left Heart Syndrome:
Cardiac progenitor cells, PMIDs: 18754813, 17502484, 14530411
Cardiac stem cells, PMIDs: 18754813, 17502484, 14530411


Cochrane evidence based reviews: hypoplastic left heart syndrome

Genetic Tests for Hypoplastic Left Heart Syndrome

About this section

Genetic tests related to Hypoplastic Left Heart Syndrome:

id Genetic test Affiliating Genes
1 Hypoplastic Left Heart Syndrome27 24 GJA1

Anatomical Context for Hypoplastic Left Heart Syndrome

About this section

MalaCards organs/tissues related to Hypoplastic Left Heart Syndrome:

36
Heart, Skin, Lung, Liver, Testes, Neutrophil, Uterus

Publications for Hypoplastic Left Heart Syndrome

About this section

Articles related to Hypoplastic Left Heart Syndrome:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Ventricular function and ventriculo-arterial coupling after palliation of hypoplastic left heart syndrome: A comparative study with Fontan patients with LV morphology. (27816303)
2017
2
Right ventricular systolic function in hypoplastic left heart syndrome: A comparison of manual and automated software to measure fractional area change. (28191731)
2017
3
Counseling Practices for Fetal Hypoplastic Left Heart Syndrome. (28345115)
2017
4
Hypoplastic Left Heart Syndrome is not Associated with Worse Clinical or Neurodevelopmental Outcomes Than Other Cardiac Pathologies After the Norwood-Sano Operation. (28341901)
2017
5
Hypoplastic left heart syndrome: from comfort care to long-term survival. (27701379)
2017
6
Interstage Home Monitoring After Newborn First-Stage Palliation for Hypoplastic Left Heart Syndrome: Family Education Strategies. (28365652)
2017
7
Recoarctation After Norwood I Procedure for Hypoplastic Left Heart Syndrome: Impact of Patch Material. (28024650)
2017
8
Evolution of Left Ventricular Size in Late Survivors of Surgery for Hypoplastic Left Heart Syndrome. (28410632)
2017
9
Practice trends over time in the care of infants with hypoplastic left heart syndrome: A report from the National Pediatric Cardiology Quality Improvement Collaborative. (28121380)
2017
10
Hypoplastic Left Heart Syndrome with Congenital Complete Heart Block. (28512719)
2017
11
Hybrid Stage I Procedure as Initial Palliation for Neonate With Hypoplastic Left Heart Syndrome and Right Congenital Diaphragmatic Hernia. (28100120)
2017
12
Mathematical Analysis and Physical Profile of Blalock-Taussig Shunt and Sano Modification Procedure in Hypoplastic Left Heart Syndrome: Review of the Literature and Implications for the Anesthesiologist. (28118786)
2017
13
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. (28254208)
2017
14
The complex genetics of hypoplastic left heart syndrome. (28530678)
2017
15
Hypoplastic left heart syndrome: a novel surgical strategy for small-volume centres? (28329111)
2017
16
Neurodevelopmental Outcome in Children after Fetal Cardiac Intervention for Aortic Stenosis with Evolving Hypoplastic Left Heart Syndrome. (28233547)
2017
17
Pressure-volume loop-derived cardiac indices during dobutamine stress: a step towards understanding limitations in cardiac output in children with hypoplastic left heart syndrome. (28043677)
2017
18
NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis. (28142228)
2017
19
Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. (28272668)
2017
20
Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. (28275592)
2017
21
Cognitive Development of School-Age Hypoplastic Left Heart Syndrome Survivors: A Single Center Study. (28508919)
2017
22
Geometry and growth of the reconstructed aorta in patients with hypoplastic left heart syndrome and variants. (28291606)
2017
23
Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome. (28012642)
2016
24
Successful Repair of Hypoplastic Left Heart Syndrome With Intact Atrial Septum, Congenital Diaphragm Hernia, and Anomalous Origin of Coronary Artery: Defying the Odds. (27343534)
2016
25
A Rare Case of Embolic ST-Elevation Myocardial Infarction in an Adult Patient With Repaired Hypoplastic Left Heart Syndrome. (27297083)
2016
26
Initial experience with live three-dimensional image overlay for ductal stenting in hypoplastic left heart syndrome. (27998845)
2016
27
Finding the correct role for heart transplant in the treatment of hypoplastic left heart syndrome. (26970470)
2016
28
CASE 8-2016 Percutaneous Fetal Cardiac Intervention for Severe Aortic Stenosis and Evolving Hypoplastic Left-Heart Syndrome. (27521972)
2016
29
Aortic arch reconstruction using a Kommerell diverticulum for hypoplastic left heart syndrome with a right aortic arch. (27038759)
2016
30
The neurodevelopmental implications of hypoplastic left heart syndrome in the fetus. (27821206)
2016
31
Neurodevelopmental outcome in hypoplastic left heart syndrome: Impact of perioperative cerebral tissue oxygenation of the Norwood procedure. (27085616)
2016
32
Changes in right ventricular function in neonates with hypoplastic left heart syndrome before and after the hybrid procedure. (26800767)
2016
33
Regenerative Medicine Strategies for Hypoplastic Left Heart Syndrome. (27245633)
2016
34
Hypoplastic left heart syndrome: What's next? (26806478)
2016
35
Decompressing vein and bilateral superior venae cavae in a patient with hypoplastic left heart syndrome. (27641733)
2016
36
Norwood Procedure for Palliation of Hypoplastic Left Heart Syndrome: Right Ventricle to Pulmonary Artery Conduit vs Modified Blalock-Taussig Shunt. (27908945)
2016
37
Effects of milk flow on the physiological and behavioural responses to feeding in an infant with hypoplastic left heart syndrome. (26982280)
2016
38
Application of the hybrid Stage 1 palliation concept to patients without hypoplastic left heart syndrome as a bridge to heart transplant. (27425401)
2016
39
Hybrid therapy for hypoplastic left heart syndrome: Myth, alternative, or standard? (26704055)
2016
40
EP07.03: Fetal intelligent navigation echocardiography (FINE) in a fetus affected by hypoplastic left heart syndrome and restrictive foramen ovale. (27646702)
2016
41
Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation. (27596010)
2016
42
Variability of antithrombotics use in patients with hypoplastic left heart syndrome and its variants following first- and second-stage palliation surgery: a national report using the National Pediatric Cardiology Quality Improvement Collaborative registry. (27981915)
2016
43
Understanding the Hybrid Stage I Approach for Hypoplastic Left Heart Syndrome. (27694357)
2016
44
Neurodevelopmental Outcome of Children with Hypoplastic Left Heart Syndrome at One and Four Years of Age Comparing Hybrid and Norwood Procedure. (27535107)
2016
45
Evaluation of right ventricular function in fetal hypoplastic left heart syndrome using spatio-temporal image correlation (STIC). (27066831)
2016
46
Tracheostomy Among Infants With Hypoplastic Left Heart Syndrome Undergoing Cardiac Operations: A Multicenter Analysis. (27865477)
2016
47
Hybrid Stage 1 Palliation in a Patient With Hypoplastic Left Heart Syndrome and Unusual Decompressing Levoatrial Cardinal Vein in Turner Syndrome: Utility of Multimodality Imaging. (27142408)
2016
48
Genetics of Hypoplastic Left Heart Syndrome. (26996724)
2016
49
Does prenatal diagnosis of hypoplastic left heart syndrome make a difference? - A systematic review. (27416335)
2016
50
Preoperative Stabilization of Infants With Hypoplastic Left Heart Syndrome Before Stage I Palliation. (26830180)
2016

Variations for Hypoplastic Left Heart Syndrome

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Copy number variations for Hypoplastic Left Heart Syndrome from CNVD:

6 (show all 21)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1140681103830000103950000DeletionHypoplastic left heart syndrome
2215891159750000159870000DuplicationHypoplastic left heart syndrome
3258021194970000195150000DeletionHypoplastic left heart syndrome
442872104197000042150000DeletionHypoplastic left heart syndrome
543118104455000044670000DuplicationHypoplastic left heart syndrome
6664811229999149999DuplicationHypoplastic left heart syndrome
767101123633000036690000DuplicationHypoplastic left heart syndrome
875411131971000019950000DeletionHypoplastic left heart syndrome
986813146579000065910000DeletionHypoplastic left heart syndrome
1089821151911000020070000DuplicationHypoplastic left heart syndrome
1190056151989000020010000DuplicationHypoplastic left heart syndrome
1290977152673000026910000DuplicationHypoplastic left heart syndrome
13105401167946999980189999DuplicationHypoplastic left heart syndrome
14113091174173000041910000DuplicationHypoplastic left heart syndrome
151353322113909999114089999DeletionHypoplastic left heart syndrome
16157162211353000013650000DeletionHypoplastic left heart syndrome
17157211211394999914129999DeletionHypoplastic left heart syndrome
18157986212817000028230000DeletionHypoplastic left heart syndrome
191600772197500009870000DeletionHypoplastic left heart syndrome
2021365864994999950009999DuplicationHypoplastic left heart syndrome
212175267101789999101909999DuplicationHypoplastic left heart syndrome

Expression for genes affiliated with Hypoplastic Left Heart Syndrome

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Search GEO for disease gene expression data for Hypoplastic Left Heart Syndrome.

Pathways for genes affiliated with Hypoplastic Left Heart Syndrome

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GO Terms for genes affiliated with Hypoplastic Left Heart Syndrome

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Cellular components related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00059169.9CDH2, GJA1

Biological processes related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1atrioventricular node developmentGO:000316210.7NKX2-5, NOTCH1
2cardiac muscle tissue morphogenesisGO:005500810.7NKX2-5, NOTCH1
3cardiac ventricle morphogenesisGO:000320810.7NKX2-5, NOTCH1
4negative regulation of myotube differentiationGO:001083210.7NKX2-5, NOTCH1
5cardiac right ventricle formationGO:000321910.7HAND1, NOTCH1
6cardiac septum morphogenesisGO:006041110.7HAND1, NOTCH1
7glomerular mesangial cell developmentGO:007214410.7FOXC2, NOTCH1
8heart contractionGO:006004710.7NKX2-5, TNNI3
9glial cell differentiationGO:001000110.6CDH2, NOTCH1
10neuronal stem cell population maintenanceGO:009715010.5CDH2, NOTCH1
11positive regulation of JAK-STAT cascadeGO:004642710.5LEP, NOTCH1
12heart loopingGO:000194710.4HAND1, NKX2-5, NOTCH1
13cardiac muscle cell proliferationGO:006003810.4FOXC2, NKX2-5, NOTCH1
14embryonic heart tube developmentGO:003505010.4FOXC2, HAND1, NKX2-5
15negative regulation of endothelial cell proliferationGO:000193710.4GJA1, XDH
16negative regulation of canonical Wnt signaling pathwayGO:009009010.3CDH2, NKX2-5, NOTCH1
17ventricular septum morphogenesisGO:006041210.3NKX2-5, NOTCH1
18cGMP biosynthetic processGO:000618210.2NPPA, NPPB
19positive regulation of p38MAPK cascadeGO:190074510.1LEP, XDH
20negative regulation of ossificationGO:003027910.1NOTCH1, SMAD6
21outflow tract septum morphogenesisGO:000314810.1NKX2-5, SMAD6
22receptor guanylyl cyclase signaling pathwayGO:000716810.1NPPA, NPPB
23ventricular cardiac muscle tissue morphogenesisGO:005501010.0FOXC2, HAND1, TNNI3
24negative regulation of cell growthGO:003030810.0GJA1, NPPA, NPPB
25pulmonary valve morphogenesisGO:000318410.0NOTCH1, SMAD6
26ventricular trabecula myocardium morphogenesisGO:000322210.0NKX2-5, NOTCH1
27regulation of cardiac conductionGO:19037799.9NKX2-5, NPPA, TNNI3
28regulation of blood vessel sizeGO:00508809.7FOXC2, NPPA, NPPB
29regulation of blood pressureGO:00082179.6LEP, NPPA, NPPB
30positive regulation of transcription, DNA-templatedGO:00458939.5FOXC2, GATA5, HAND1, NKX2-5, NOTCH1
31negative regulation of transcription from RNA polymerase II promoterGO:00001229.3EHMT1, FOXC2, HAND1, LEP, NKX2-5, NOTCH1
32heart developmentGO:00075079.3FOXC2, FOXL1, GJA1, HAND1, NKX2-5, NOTCH1

Molecular functions related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:005142810.3LEP, NPPA
2transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370510.1FOXC2, GATA5, NKX2-5
3transcriptional activator activity, RNA polymerase II transcription factor bindingGO:000119010.0NKX2-5, NOTCH1
4hormone activityGO:00051799.8LEP, NPPA, NPPB
5chromatin bindingGO:00036829.4GATA5, NKX2-5, NOTCH1, SMAD6
6sequence-specific DNA bindingGO:00435659.3FOXC2, FOXL1, GATA5, HAND1, NKX2-5, NOTCH1
7transcription factor activity, sequence-specific DNA bindingGO:00037008.7FOXC2, FOXL1, GATA5, NKX2-5, NOTCH1, SMAD6
8transcription regulatory region DNA bindingGO:00442128.6FOXC2, GATA5, HAND1, NKX2-5, SMAD6

Sources for Hypoplastic Left Heart Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet