Hypoproteinemia, Hypercatabolic malady

MalaCards: Hypoproteinemia, Hypercatabolic is related to pemphigus and acute kidney tubular necrosis. An important gene associated with Hypoproteinemia, Hypercatabolic is FCGRT (Fc fragment of IgG, receptor, transporter, alpha). The compounds ivig and polyether sulfone have been mentioned in the context of this disorder.

OMIM: 241600

hypoproteinemia, hypercatabolic 33 32

Diseases related to hypoproteinemia, hypercatabolic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 56)

id	Related Disease	Score	Top Affiliating Genes
1	pemphigus	12.7	ALB, FCGRT
2	acute kidney tubular necrosis	12.6	B2M, ALB
3	chronic pyelonephritis	12.6	B2M, ALB
4	twin-to-twin transfusion syndrome	12.6	ALB, B2M
5	twin twin transfusion syndrome	12.6	B2M, ALB
6	chronic rapidly progressive glomerulonephritis	12.6	ALB, B2M
7	steroid-resistant nephrotic syndrome	12.6	ALB, B2M
8	interstitial nephritis	12.6	B2M, ALB
9	intestinal pseudo-obstruction	12.6	ALB, B2M
10	meningoencephalitis	12.6	ALB, B2M
11	castleman's disease	12.6	ALB, B2M
12	nephrosis	12.6	B2M, ALB
13	tick-borne encephalitis	12.6	B2M, ALB
14	hypophosphatemia	12.6	ALB, B2M
15	hypercalciuria	12.6	B2M, ALB
16	pyelonephritis	12.6	B2M, ALB
17	hairy cell leukemia	12.6	B2M, ALB
18	wilson disease	12.5	B2M, ALB
19	macroglobulinemia	12.5	B2M, ALB
20	primary hyperparathyroidism	12.5	ALB, B2M
21	hepatitis a	12.5	B2M, ALB
22	primary hyperoxaluria	12.5	B2M, ALB
23	human immunodeficiency virus infectious disease	12.5	B2M, ALB
24	iron overload	12.5	B2M, ALB
25	retinol binding protein	12.5	ALB, B2M
26	hypercalcemia	12.5	B2M, ALB
27	familial mediterranean fever	12.5	B2M, ALB
28	beta thalassemia	12.5	ALB, B2M
29	acquired immunodeficiency syndrome	12.5	ALB, B2M
30	uremia	12.5	ALB, B2M
31	polyneuropathy	12.5	B2M, ALB
32	photosensitive trichothiodystrophy	12.5	B2M, ALB
33	type 1 diabetes mellitus	12.5	ALB, B2M
34	hypersensitivity reaction type ii disease	12.5	ALB, B2M
35	small cell carcinoma	12.5	ALB, B2M
36	connective tissue disease	12.4	B2M, ALB
37	viral hepatitis	12.4	ALB, B2M
38	hemorrhagic fever	12.4	B2M, ALB
39	common variable immunodeficiency	12.4	FCGRT, B2M
40	uveitis	12.4	ALB, B2M
41	congestive heart failure	12.4	ALB, B2M
42	pulmonary tuberculosis	12.4	ALB, B2M
43	sickle cell disease	12.4	ALB, B2M
44	amyloidosis	12.4	ALB, B2M
45	hyperthyroidism	12.3	B2M, ALB
46	thalassemia	12.3	B2M, ALB
47	secondary hyperparathyroidism of renal origin	12.3	ALB, B2M
48	adult t-cell leukemia	12.2	B2M, ALB
49	myocarditis	12.2	B2M, ALB
50	acute pancreatitis	12.1	ALB, B2M

Clinical features from OMIM: 241600

Approved drugs:

Drug clinical trials:

Genes related to hypoproteinemia, hypercatabolic according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	FCGRT	Fc fragment of IgG, receptor, transporter, alpha	11.1
2	B2M	beta-2-microglobulin	11.1
3	ALB	albumin	11.1

Compounds related to hypoproteinemia, hypercatabolic according to GeneDecks:

(show all 29)

id	Compound	Score	Top Affiliating Genes
1	ivig32	9.6	ALB, FCGRT
2	polyether sulfone32	9.5	ALB, B2M
3	iopentol32	9.5	ALB, B2M
4	51-cr-edta32	9.5	ALB, B2M
5	p-aminohippuric acid32	9.5	B2M, ALB
6	icodextrin32 9 9	11.5	B2M, ALB
7	inulin32	9.5	ALB, B2M
8	gamma globulin32	9.5	B2M, ALB
9	iohexol32	9.5	B2M, ALB
10	pentosidine32	9.5	B2M, ALB
11	sevoflurane32 9 9	11.5	B2M, ALB
12	l-tryptophan32 9 18 9	12.5	B2M, ALB
13	polysulfone32	9.5	B2M, ALB
14	cellulose acetate32	9.4	ALB, B2M
15	25-hydroxyvitamin d32	9.4	B2M, ALB
16	phosphorus32	9.4	ALB, B2M
17	captopril32 42 9 9	12.4	B2M, ALB
18	vitamin b1232	9.4	ALB, B2M
19	bicarbonate32	9.4	B2M, ALB
20	zidovudine32 9 9	11.3	ALB, B2M
21	uric acid32 18	10.3	ALB, B2M
22	mannitol32 9 9	11.3	ALB, B2M
23	urea32 9 18 9	12.2	ALB, B2M
24	thyroxine32 18	10.2	B2M, ALB
25	hyaluronic acid32 18	10.1	ALB, B2M
26	vitamin a32 9 18 9	12.1	B2M, ALB
27	folate32	9.0	B2M, ALB
28	calcitriol32 42 9 18 9	12.8	ALB, B2M
29	iron32 18	9.8	ALB, B2M, FCGRT

Cellular components related to hypoproteinemia, hypercatabolic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	9.0	B2M, FCGRT