MCID: HYP620
MIFTS: 54

Hypoprothrombinemia malady

Categories: Genetic diseases, Rare diseases, Blood diseases

Aliases & Classifications for Hypoprothrombinemia

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Aliases & Descriptions for Hypoprothrombinemia:

Name: Hypoprothrombinemia 51 11 24 25 53 69
Dysprothrombinemia 51 24 25 53 69 12 49
Prothrombin Deficiency 11 24 25 53 69 13
Factor Ii Deficiency 11 25 69 67
Prothrombin Deficiency, Congenital 51 26
Hypoprothrombinemias 49 38
 
Hereditary Factor Ii Deficiency Disease 67
Congenital Factor Ii Deficiency 53
Inherited Factor Ii Deficiency 67
Factor 2 Deficiency 47
Fa2d 69

Characteristics:

Orphanet epidemiological data:

53
dysprothrombinemia:
Inheritance: Autosomal recessive; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age

HPO:

63
hypoprothrombinemia:
Inheritance: autosomal recessive inheritance
Onset and clinical course: congenital onset, variable expressivity

Classifications:



External Ids:

OMIM51 613679
Disease Ontology11 DOID:2235
MeSH38 D007020
Orphanet53 ORPHA325
ICD10 via Orphanet30 D68.2

Summaries for Hypoprothrombinemia

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OMIM:51 Prothrombin deficiency is an extremely rare autosomal recessive bleeding disorder characterized by low levels of... (613679) more...

MalaCards based summary: Hypoprothrombinemia, also known as dysprothrombinemia, is related to systemic lupus erythematosus and factor v deficiency, and has symptoms including menorrhagia, gingival bleeding and epistaxis. An important gene associated with Hypoprothrombinemia is F2 (Coagulation Factor II, Thrombin), and among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. The drugs menadiol and menadiol sodium phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain and liver, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Genetics Home Reference:25 Prothrombin deficiency is a bleeding disorder that slows the blood clotting process. People with this condition often experience prolonged bleeding following an injury, surgery, or having a tooth pulled. In severe cases of prothrombin deficiency, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Women with prothrombin deficiency can have prolonged and sometimes abnormally heavy menstrual bleeding. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of prothrombin deficiency do not involve spontaneous bleeding, and the condition may only become apparent following surgery or a serious injury.

UniProtKB/Swiss-Prot:69 Factor II deficiency: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.

Wikipedia:70 Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in... more...

Related Diseases for Hypoprothrombinemia

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Diseases in the Hypoprothrombinemia family:

Acquired Hypoprothrombinemia

Diseases related to Hypoprothrombinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus29.5APOH, F2, F3, TNFSF13B
2factor v deficiency27.9APOH, F10, F2, F3, F5, F7
3acquired hypoprothrombinemia12.1
4acute zonal occult outer retinopathy10.6F2, F5
5bartholin's gland adenoma10.6F2, F5
6coenzyme q cytochrome c reductase deficiency of10.6APOH, F5
7onychocytic matricoma10.6APOH, F5
8cholesterol embolism10.6APOH, F2
9tympanosclerosis10.6F2, F5
10milk allergy10.6F2, SERPINC1
11homocystinuria due to defect in methylation cbl g10.6F2, F5
12pregnancy loss, recurrent 110.6APOH, F5
13hypertensive heart disease10.6F2, SERPINC1
14primary pigmented nodular adrenocortical disease10.6F2, F5
15spleen cancer10.6F2, SERPINC1
16familial glomangioma10.5F2, F3
17west nile fever10.5F2, F5
18posterolateral myocardial infarction10.5F2, SERPINC1
19cerebral angioma10.5F2, F3
20dislocation of ear ossicle10.5F2, F3
21von willibrand disease, type 310.5F2, F3
22epididymo-orchitis10.5F2, F3
23histoplasmosis10.5F2, SERPINC1
24chorea gravidarum10.5F2, F3
25peroneal neuropathy10.5F2, F3
26hepatocellular adenoma10.5F2, F5
27mirage syndrome10.5F3, TPMT
28elejalde disease10.5APOH, F2
29splenic infarction10.5F2, F3
30cavernous sinus thrombosis10.5F3, SERPINC1
31wfs1-related disorders10.5F2, F3
32diabetic autonomic neuropathy10.4F2, F9
33typhoid fever10.4F2, F7
34cercarial dermatitis10.4F2, F3
35inherited blood coagulation disease10.4F2, F3
36childhood central nervous system germinoma10.4APOH, F5
37retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.4F10, F5
38chronic diarrhea due to guanylate cyclase 2c overactivity10.4F3, SERPINC1
39unicentric castleman disease10.4APOH, F2, F5
40glossopharyngeal nerve disease10.4F10, F3
41anterior foramen magnum meningioma10.4F2, SERPINC1
42noma10.4APOH, F2, F5
43thyroid hyalinizing trabecular adenoma10.4F2, F5, SERPINC1
44polyhydramnios10.4F2, F5, SERPINC1
45functional colonic disease10.4F2, F5, SERPINC1
46exophthalmic ophthalmoplegia10.3F2, F5, SERPINC1
47pancreatic solid pseudopapillary carcinoma10.3F2, F7
48borderline glaucoma10.3F2, F5, SERPINC1
49frontal sinus cancer10.3F2, F5, SERPINC1
50sacrococcygeal teratoma10.3APOH, F2, SERPINC1

Graphical network of the top 20 diseases related to Hypoprothrombinemia:



Diseases related to hypoprothrombinemia

Symptoms for Hypoprothrombinemia

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Symptoms by clinical synopsis from OMIM:

613679

Clinical features from OMIM:

613679

Human phenotypes related to Hypoprothrombinemia:

 63 (show all 10)
id Description HPO Frequency HPO Source Accession
1 menorrhagia63 HP:0000132
2 gingival bleeding63 HP:0000225
3 epistaxis63 HP:0000421
4 bruising susceptibility63 HP:0000978
5 gastrointestinal hemorrhage63 HP:0002239
6 prolonged bleeding time63 HP:0003010
7 prolonged partial thromboplastin time63 HP:0003645
8 joint hemorrhage63 HP:0005261
9 prolonged prothrombin time63 HP:0008151
10 reduced prothrombin activity63 HP:0012201

Drugs & Therapeutics for Hypoprothrombinemia

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Drugs for Hypoprothrombinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
WarfarinapprovedPhase 1, Phase 245481-81-26691, 54678486
Synonyms:
(-)-Warfarin
(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
(S)-Warfarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
200 Coumarin
200 coumarin
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine
45706_FLUKA
45706_RIEDEL
4oh-coumarin deriv.
5543-56-6
5543-57-7
81-81-2
A2250_FLUKA
A2250_SIGMA
AC-15978
AC1L1N37
AC1Q6AN3
AR-1E2310
Arab Rat Death
Arab rat death
Arab rat deth
Athrombin
Athrombin-K
Athrombin-k
Athrombine-K
Athrombine-k
BRD-A24514565-001-02-2
BRD-A24514565-236-01-6
BRN 1293536
BSPBio_002026
Bio-0586
Brumolin
C01541
C19H16O4
CBDivE_002127
CBDivE_013236
CBKinase1_000192
CBKinase1_012592
CHEBI:10033
CHEMBL1464
CID6691
CO-Rax
Caswell No. 903
Choice
Choice (TN)
Co-Rax
Co-rax
Compound 42
Coumadin
Coumadin Tabs
Coumafen
Coumafene
Coumafene [French]
Coumaphen
Coumaphene
Coumarins
Coumefene
Cov-R-Tox
Cov-R-tox
D-Con
D08682
DB00682
DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
Dethmor
Dethnel
Dicusat E
Dicusat e
DivK1c_000444
EINECS 201-377-6
EINECS 226-907-3
EPA Pesticide Chemical Code 086002
Eastern states duocide
Fasco fascrat powder
Frass-Ratron
Frass-ratron
HMS1921K07
HMS2092C20
HMS501G06
HSDB 1786
I14-0958
IDI1_000444
Jantoven
KBio1_000444
KBio2_000674
KBio2_003242
KBio2_005810
KBio3_001526
KBioGR_000901
KBioSS_000674
Killgerm sewarin p
Kumader
Kumadu
Kumatox
Kypfarin
LS-55083
Latka 42
Latka 42 [Czech]
Liqua-tox
MLS001304042
Maag Rattentod Cum
Maag rattentod cum
Mar-Frin
Mar-frin
Marevan
Martin'S mar-frin
Martin's mar-frin
 
Maveran
MolPort-001-787-822
Mouse pak
NCGC00094810-01
NCGC00094810-02
NCGC00159398-03
NCGC00178855-01
NINDS_000444
NSC 59813
NSC59813
PS104_SUPELCO
Panwarfin
Place-Pax
Place-pax
Prothromadin
RAX
RCR grey squirrel killer concentrate
RCRA waste no. P001
Rat & mice bait
Rat and mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-O-cide no. 2
Rat-Ola
Rat-Trol
Rat-a-way
Rat-alpha-way
Rat-b-gon
Rat-beta-gon
Rat-gard
Rat-kill
Rat-mix
Rat-o-cide #2
Rat-ola
Rat-trol
Ratorex
Ratox
Ratoxin
Ratron
Ratron G
Ratron g
Rats-no-more
Ratten-Koederrohr
Ratten-koederrohr
Rattenstreupulver Neu Schacht
Rattenstreupulver neu schacht
Rattenstreupulver new schacht
Rattentraenke
Rattunal
Rcra waste number P001
Ro-Deth
Ro-deth
Rodafarin
Rodafarin C
Rodafarin c
Rodex
Rodex blox
Rosex
Rough & ready mouse mix
Rough and ready mouse mix
SMP1_000316
SMR000718754
SPBio_000870
SPECTRUM1500613
STK364490
Sakarat
Sewarin
Sofarin
Solfarin
Sorexa Plus
Sorexa plus
Spectrum2_000935
Spectrum3_000583
Spectrum4_000381
Spectrum5_001751
Spectrum_000194
Spray-trol brand roden-trol
Temus W
Temus w
Tintorane
Tox-Hid
Tox-hid
Twin light rat away
UNII-5Q7ZVV76EI
Vampirinip II
Vampirinip III
Vampirinip iii
W.A.R.F. 42
WARF compound 42
WLN: T66 BOVJ DYR&1V1 EQ
Waran
Warf 10
Warf 42
Warfarat
Warfarin (INN)
Warfarin (and salts of)
Warfarin Plus
Warfarin Q
Warfarin [BSI:ISO]
Warfarin [INN:BAN]
Warfarin plus
Warfarin plus [discontinued]
Warfarin sodium
Warfarin titrated to an INR of 2.5-3.0
Warfarin(R)
Warfarina
Warfarina [INN-Spanish]
Warfarine
Warfarine [INN-French]
Warfarine [ISO-French]
Warfarinum
Warfarinum [INN-Latin]
Warficide
Warfilone
Zoocoumarin
Zoocoumarin [Netherlands and USSR]
Zoocoumarin [Russian]
delta-Con
nchembio.307-comp19
rac-Warfarin
warfarin
2Liver ExtractsPhase 23868
3AnticoagulantsPhase 1, Phase 22516
4Anti-Infective Agents21402
5Anti-Bacterial Agents10884
6Antibiotics, Antitubercular6972

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated CirrhosisCompletedNCT00562783Phase 2
2Randomized Controlled Feasibility Trial of the Fearon Algorithm to Improve Management of Unstable WarfarinRecruitingNCT02267408Phase 1, Phase 2
3Antibiotic-associated CoagulopathyUnknown statusNCT02172833

Search NIH Clinical Center for Hypoprothrombinemia

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: hypoprothrombinemias

Genetic Tests for Hypoprothrombinemia

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Genetic tests related to Hypoprothrombinemia:

id Genetic test Affiliating Genes
1 Prothrombin Deficiency, Congenital26
2 Prothrombin Deficiency24 F2

Anatomical Context for Hypoprothrombinemia

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MalaCards organs/tissues related to Hypoprothrombinemia:

35
Brain, Liver

Animal Models for Hypoprothrombinemia or affiliated genes

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MGI Mouse Phenotypes related to Hypoprothrombinemia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0F10, F11, F2, F3, F5, F7
2MP:00053767.4APOH, F10, F11, F2, F3, F5
3MP:00107686.6APOH, F10, F11, F2, F3, F5

Publications for Hypoprothrombinemia

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Articles related to Hypoprothrombinemia:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Lupus anticoagulant-hypoprothrombinemia syndrome and catastrophic antiphospholipid syndrome in a patient with antidomain I antibodies. (27380476)
2016
2
Lupus anticoagulant-hypoprothrombinemia syndrome presenting with co-existing cerebral venous thrombosis and subdural hemorrhage. (27743753)
2016
3
Lupus anticoagulant - hypoprothrombinemia syndrome: a rare cause of intracranial bleeding. (28009646)
2016
4
Lupus anticoagulant hypoprothrombinemia syndrome associated with severe thrombocytopenia in a child. (27862892)
2016
5
Prozone Effect in the Diagnosis of Lupus Anticoagulant for the Lupus Anticoagulant-Hypoprothrombinemia Syndrome. (27473743)
2016
6
A case of lupus anticoagulant-hypoprothrombinemia syndrome associated with systemic lupus erythematosus. (26654379)
2015
7
Lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature. (25391540)
2015
8
Lupus anticoagulant acquired hypoprothrombinemia syndrome in childhood: two distinct patterns and review of the literature. (25929557)
2015
9
Lupus anticoagulant-hypoprothrombinemia syndrome: A rare association in systemic lupus erythematosus. (26306946)
2015
10
Role of prophylactic vitamin K in preventing antibiotic induced hypoprothrombinemia. (25297643)
2015
11
Bruised Black and Blue: Acquired Hypoprothrombinemia. (26159638)
2015
12
Activated partial thromboplastin time sensitivity to lupus anticoagulant in a patient with transient arthritis and lupus anticoagulant-hypoprothrombinemia syndrome. (25380995)
2014
13
Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome. (24868219)
2014
14
Cerebral microbleeds in lupus anticoagulant-hypoprothrombinemia syndrome. (24081384)
2013
15
Resolution of Hypoprothrombinemia-Lupus Anticoagulant Syndrome (HLAS) after multidrug therapy with rituximab: a case report and review of the literature. (22989209)
2013
16
Lupus anticoagulant hypoprothrombinemia syndrome in Bence-Jones protein I_-type multiple myeloma patient with phosphatidylserine-dependent antiprothrombin antibody. (23076754)
2013
17
Acquired hypoprothrombinemia inducing bleeding in a girl with transient antiphospholipid antibody: case report. (22435262)
2012
18
Lupus Anticoagulant-Hypoprothrombinemia syndrome (HLAS): report of one case in a familial infectious context. (20006899)
2010
19
Control of ovulation-induced hemoperitoneum by oral contraceptives in a patient with congenital hypoprothrombinemia and in another with congenital factor V deficiency. (18583905)
2008
20
Cefazolin-induced hypoprothrombinemia. (18436729)
2008
21
Lupus anticoagulant-hypoprothrombinemia in healthy adult. (18787368)
2008
22
Steady improvement of prothrombin levels after cyclophosphamide therapy in pediatric lupus anticoagulant hypoprothrombinemia syndrome (LAHPS). (17516128)
2007
23
Pre-operative management of a patient with hypoprothrombinemia-lupus anticoagulant syndrome. (17598020)
2007
24
Quinidine-induced lupus anticoagulant, hypoprothrombinemia, and antiprothrombin antibodies. (16955465)
2007
25
Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome. (16924686)
2006
26
Enhanced hypoprothrombinemia with warfarin due to azithromycin. (15084685)
2004
27
Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. (12228189)
2002
28
Diagnosis of lupus anticoagulant in the lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature. (12410576)
2002
29
Successful treatment of acquired hypoprothrombinemia without associated lupus anticoagulant using intravenous immunoglobulin. (11410426)
2001
30
Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia. (11005360)
2000
31
Acquired hypoprothrombinemia related to high titres of antiprotein-phospholipid antibodies. (10064016)
1999
32
Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. Case report and review of literature. (9234588)
1997
33
Hypoprothrombinemia associated with cefmetazole. (9034420)
1997
34
Molecular analysis of a compound heterozygote for hypoprothrombinemia and dysprothrombinemia (-G 7248/7249 and ARG 340 TRP). (9351523)
1997
35
Association of lupus anticoagulant with transient antibodies to prothrombin in a patient with hypoprothrombinemia. (9172289)
1997
36
Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia. (8839854)
1996
37
Acquired hypoprothrombinemia: effects of danazol treatment. (8948670)
1996
38
Hypoprothrombinemia in childhood systemic lupus erythematosus. (7985033)
1994
39
Transient lupus anticoagulant associated with hypoprothrombinemia and factor XII deficiency following adenovirus infection. (8394145)
1993
40
Molecular and genetic analysis of a compound heterozygote for dysprothrombinemia of prothrombin Tokushima and hypoprothrombinemia. (1334372)
1992
41
Hypoprothrombinemia and hemorrhage in a surgical patient treated with cefotetan. (1901205)
1991
42
Antibiotic-associated hypoprothrombinemia: a review of prospective studies, 1966-1988. (2267487)
1990
43
Severe hemorrhage in a patient with circulating anticoagulant, acquired hypoprothrombinemia, and systemic lupus erythematosus. (3139005)
1988
44
Acquired hypoprothrombinemia due to non-neutralizing antibodies to prothrombin: mechanism and management. (3995183)
1985
45
Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol. (2865352)
1985
46
Prothrombin complex concentrates in acquired hypoprothrombinemia. (4748270)
1973
47
MEGALOBLASTIC ANEMIA, THROMBOCYTOPENIA, AND ASSOCIATED HYPOPROTHROMBINEMIA AND HYPOPROCONVERTINEMIA IN PREGNANCY. REPORT OF A CASE. (14082291)
1963
48
Acquired hypoprothrombinemia. (13382992)
1957
49
Acute phosphorus poisoning: a case with severe granulocytopenia and hypoprothrombinemia. (13489461)
1957
50
Hypoprothrombinemia with hemorrhage as a cause of death in the rat in hypervitaminosis A. (18916905)
1948

Variations for Hypoprothrombinemia

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UniProtKB/Swiss-Prot genetic disease variations for Hypoprothrombinemia:

69
id Symbol AA change Variation ID SNP ID
1F2p.Glu200LysVAR_006711rs62623459
2F2p.Arg314CysVAR_006712rs121918477
3F2p.Arg314HisVAR_006713rs754231232
4F2p.Met380ThrVAR_006714rs121918481
5F2p.Arg425CysVAR_006715rs121918479
6F2p.Arg431HisVAR_006716rs121918482
7F2p.Arg461TrpVAR_006717rs121918478
8F2p.Glu509AlaVAR_006718
9F2p.Gly601ValVAR_006719rs121918480
10F2p.Glu72GlyVAR_055232

Clinvar genetic disease variations for Hypoprothrombinemia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1F2NM_000506.4(F2): c.462_463insT (p.Asn155Terfs)insertionPathogenicrs387906522GRCh37Chr 11, 46744971: 46744972
2F2NM_000506.4(F2): c.*97G> ASNVPathogenic, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
3F2F2, TYR44CYSSNVPathogenicChr na, -1: -1

Expression for genes affiliated with Hypoprothrombinemia

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Search GEO for disease gene expression data for Hypoprothrombinemia.

Pathways for genes affiliated with Hypoprothrombinemia

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GO Terms for genes affiliated with Hypoprothrombinemia

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Cellular components related to Hypoprothrombinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:003123310.5F10, F3
2Golgi lumenGO:00057969.4F10, F2, F7, F9
3endoplasmic reticulum lumenGO:00057889.1F10, F2, F5, F7, F9
4extracellular exosomeGO:00700627.8APOH, F11, F2, F3, F9, SERPINC1
5extracellular regionGO:00055767.1APOH, F10, F11, F2, F5, F7
6extracellular spaceGO:00056156.9APOH, F11, F2, F3, F5, F7
7plasma membraneGO:00058866.4APOH, F10, F11, F2, F3, F5

Biological processes related to Hypoprothrombinemia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:005191810.3APOH, F2
2positive regulation of platelet-derived growth factor receptor signaling pathwayGO:001064110.2F3, F7
3positive regulation of positive chemotaxisGO:005092710.0F3, F7
4regulation of blood coagulationGO:00301939.8APOH, F11, F2
5plasminogen activationGO:00316399.8APOH, F11
6positive regulation of protein kinase B signalingGO:00518979.5F10, F3, F7
7peptidyl-glutamic acid carboxylationGO:00171879.4F10, F2, F7, F9
8positive regulation of blood coagulationGO:00301949.4APOH, F2, F7
9signal peptide processingGO:00064659.3F10, F2, F7, F9
10blood coagulation, extrinsic pathwayGO:00075989.3F10, F3, F7, F9
11positive regulation of cell migrationGO:00303359.2F10, F3, F7
12blood coagulation, intrinsic pathwayGO:00075979.0APOH, F10, F11, F2, F9
13ER to Golgi vesicle-mediated transportGO:00068888.8F10, F2, F5, F7, F9
14blood coagulationGO:00075966.9F10, F11, F2, F3, F5, F7

Molecular functions related to Hypoprothrombinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.4APOH, F11, SERPINC1
2phospholipid bindingGO:00055439.1APOH, F10, F3
3serine-type endopeptidase activityGO:00042527.5F10, F11, F2, F3, F5, F7

Sources for Hypoprothrombinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet