MCID: HYP226
MIFTS: 32

Hyporeninemic Hypoaldosteronism malady

Rare diseases category

Summaries for Hyporeninemic Hypoaldosteronism

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MalaCards based summary: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and glomerulosclerosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cyproteroneacetate and remikiren have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Hyporeninemic Hypoaldosteronism, Aliases & Descriptions:

Name: Hyporeninemic Hypoaldosteronism 41
Hypoaldosteronism, Hyporeninemic 60
 
Hypoaldosteronism Hyporeninemic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hyporeninemic Hypoaldosteronism

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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism32.4REN
2glomerulosclerosis30.6ACE, REN
3autonomic neuropathy30.6REN, INS
4hypokalemia30.1INS, REN, ACE
5systemic lupus erythematosus10.5
6lupus erythematosus10.5
7multiple myeloma10.4
8glomerulonephritis10.4
9myeloma10.4
10fibromuscular dysplasia10.4REN
11hepatorenal syndrome10.4REN
12oligohydramnios10.3ACE
13chronic lymphocytic leukemia10.3
14leukemia10.3
15liver cirrhosis10.3
16renal tubular acidosis10.3
17addison's disease10.3
18metabolic acidosis10.3
19amyloidosis10.3
20kidney disease10.3
21lactic acidosis10.3
22nephrotic syndrome10.3
23neuropathy10.3
24sickle cell disease10.3
25acth deficiency10.3
26mental retardation10.3
27secondary amyloidosis10.3
28cushing's syndrome10.1REN, INS
29idiopathic edema10.0INS, ACE
30cork-handlers' disease10.0INS, ACE
31renal tubular dysgenesis10.0ACE, REN
32malignant hypertension10.0ACE, REN
33hypertension, diastolic10.0REN, ACE
34microvascular complications of diabetes 510.0ACE, INS
35renovascular hypertension10.0REN, ACE
36renal hypertension10.0REN, ACE
37lipid metabolism disorder10.0INS, ACE
38pure autonomic failure10.0REN, ACE
39familial hyperlipidemia10.0INS, ACE
40hyperaldosteronism10.0REN, ACE
41hypercholesterolemia, familial10.0INS, ACE
42polycystic kidney disease, autosomal dominant10.0REN, ACE
43diabetes mellitus, insulin-dependent10.0ACE, INS
44congestive heart failure10.0ACE, REN
45vascular disease9.9INS, ACE
46hyperglycemia9.9INS, ACE
47coronary artery disease9.9ACE, INS
48primary hyperoxaluria9.9REN, ACE
49diabetes mellitus, noninsulin-dependent9.9INS, ACE
50congenital heart disease9.8ACE, REN

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Symptoms for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

31
Kidney, Liver

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, REN, INS
2MP:00053898.6INS, REN, ACE
3MP:00053858.5ACE, REN, INS
4MP:00053878.5ACE, REN, INS
5MP:00053978.4INS, REN, ACE
6MP:00053868.2ACE, REN, INS

Publications for Hyporeninemic Hypoaldosteronism

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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Prerenal azotemia in a diabetic patient with hyporeninemic hypoaldosteronism and autonomic neuropathy. (10566125)
1999
9
Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. (9627045)
1998
10
Accidental shock during epidural anesthesia in a patient with NSAID-induced hyporeninemic hypoaldosteronism. (9257212)
1997
11
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
12
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
13
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
14
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
15
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
16
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
17
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
18
A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]. (1607144)
1992
19
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
20
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia. (2543544)
1989
21
Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. (3394721)
1988
22
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
23
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
24
Hyperkalemic distal renal tubular acidosis with hyporeninemic hypoaldosteronism in a patient with systemic lupus erythematosus--a case report. (3441801)
1987
25
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
26
Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. (3515183)
1986
27
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
28
Hyporeninemic hypoaldosteronism in children with chronic renal failure. (3528445)
1986
29
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
30
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism. (3918448)
1985
31
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
32
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
33
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
34
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
35
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
36
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
37
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia. (6750425)
1982
38
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
39
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
40
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. (6996036)
1980
41
Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. (6986536)
1980
42
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
43
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
44
Hyporeninemic hypoaldosteronism--case report and observation of dissociated renin and erythropoietin activity. (670540)
1978
45
Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. (591294)
1977
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse. (971018)
1976
48
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
49
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0ACE, REN
2
Show member pathways
8.5INS, REN, ACE
3
Show member pathways
8.5ACE, REN, INS
4
Show member pathways
8.5ACE, REN, INS

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate439.6INS, REN
2remikiren43 1210.5REN, ACE
3sampatrilat439.5ACE, REN
4ibopamine439.5REN, ACE
5alacepril439.5ACE, REN
6perindoprilat439.5ACE, REN
7aliskiren43 1210.5REN, ACE
8lacidipine439.5REN, ACE
9indapamide43 1210.5REN, ACE
10dihydralazine439.4REN, ACE
11bucindolol43 4910.4ACE, REN
12doxazosin43 1210.4ACE, INS
13saralasin439.4REN, ACE
14eprosartan43 28 1211.4ACE, REN
15bisoprolol43 49 1211.4ACE, REN
16omapatrilat439.4REN, ACE
17trandolapril43 1210.4REN, ACE
18cilazapril43 1210.4REN, ACE
19eplerenone43 59 28 1212.4ACE, REN
20fosinopril43 1210.4REN, ACE
21benazepril43 49 1211.4REN, ACE
22quinapril43 49 1211.4REN, ACE
23enalaprilat439.4REN, ACE
24lisinopril43 49 24 1212.4ACE, REN
25metoprolol43 49 28 24 1213.4ACE, REN
26chymostatin439.4REN, ACE
27hydralazine43 49 1211.4REN, ACE
28valsartan43 59 28 1212.4ACE, REN
29perindopril43 49 1211.4REN, ACE
30atenolol43 49 28 24 1213.3ACE, REN
31irbesartan43 28 49 1212.3ACE, REN
32felodipine43 28 1211.3ACE, REN
33dihydropyridine439.3ACE, REN
34candesartan43 49 28 1212.3ACE, REN
35diltiazem43 28 49 1212.2ACE, REN
36hydrochlorothiazide43 28 49 24 1213.2REN, ACE
37amlodipine43 49 24 1212.2ACE, REN
38enalapril43 49 1211.1REN, ACE
39spironolactone43 59 28 49 1213.1ACE, REN
40carvedilol43 49 28 1212.0REN, ACE
41digoxin43 59 49 24 1213.0ACE, REN
42olmesartan43 28 1211.0ACE, REN, INS
43moxonidine439.0INS, REN, ACE
44ramipril43 1210.0ACE, REN, INS
45thiazide439.0REN, INS, ACE
46telmisartan43 28 1211.0ACE, INS, REN
47nitroglycerin43 129.9REN, ACE
48norepinephrine43 24 1210.9ACE, REN, INS
49creatinine438.7INS, REN, ACE
50cholesterol43 28 24 1211.2INS, ACE, REN

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5ACE, REN, INS
2extracellular spaceGO:00056158.2ACE, REN, INS

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:00020039.0ACE, REN
2kidney developmentGO:00018229.0ACE, REN
3regulation of blood pressureGO:00082178.7ACE, REN
4cellular protein metabolic processGO:00442678.4ACE, REN, INS

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.3REN, INS

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources for Hyporeninemic Hypoaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet