MCID: HYP226
MIFTS: 37

Hyporeninemic Hypoaldosteronism malady

Rare diseases category

Summaries for Hyporeninemic Hypoaldosteronism

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MalaCards based summary: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and glomerulosclerosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cyproteroneacetate and remikiren have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Hyporeninemic Hypoaldosteronism, Aliases & Descriptions:

Name: Hyporeninemic Hypoaldosteronism 42
Hypoaldosteronism, Hyporeninemic 61
 
Hypoaldosteronism Hyporeninemic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hyporeninemic Hypoaldosteronism

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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism32.3REN
2glomerulosclerosis30.6ACE, REN
3hypertension30.3REN, INS, ACE
4hypokalemia30.1INS, REN, ACE
5diabetic nephropathy30.1REN, INS, ACE
6diabetes mellitus30.0INS, REN, ACE
7systemic lupus erythematosus10.5
8lupus erythematosus10.5
9glomerulonephritis10.4
10multiple myeloma10.4
11myeloma10.4
12fibromuscular dysplasia10.4REN
13hepatorenal syndrome10.4REN
14oligohydramnios10.3ACE
15chronic lymphocytic leukemia10.3
16leukemia10.3
17liver cirrhosis10.3
18renal tubular acidosis10.3
19addison's disease10.3
20metabolic acidosis10.3
21amyloidosis10.3
22kidney disease10.3
23lactic acidosis10.3
24nephrotic syndrome10.3
25sickle cell disease10.3
26isolated acth deficiency10.3
27acth deficiency10.3
28mental retardation10.3
29autonomic neuropathy10.1REN, INS
30cushing's syndrome10.1REN, INS
31idiopathic edema10.1INS, ACE
32cork-handlers' disease10.0INS, ACE
33renal tubular dysgenesis10.0ACE, REN
34malignant hypertension10.0ACE, REN
35hypertension, diastolic10.0REN, ACE
36diabetic retinopathy10.0ACE, INS
37renovascular hypertension10.0REN, ACE
38renal hypertension10.0REN, ACE
39pure autonomic failure10.0REN, ACE
40familial hyperlipidemia10.0INS, ACE
41hyperaldosteronism10.0REN, ACE
42hypercholesterolemia10.0INS, ACE
43type 1 diabetes mellitus10.0ACE, INS
44polycystic kidney disease, autosomal dominant10.0REN, ACE
45congestive heart failure10.0ACE, REN
46vascular disease10.0INS, ACE
47hyperglycemia9.9INS, ACE
48coronary artery anomaly9.9ACE, INS
49primary hyperoxaluria9.9REN, ACE
50type 2 diabetes mellitus9.9ACE, INS

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Symptoms for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

32
Kidney, Liver

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, REN, INS
2MP:00053898.6INS, REN, ACE
3MP:00053858.5ACE, REN, INS
4MP:00053878.5ACE, REN, INS
5MP:00053978.4INS, REN, ACE
6MP:00053868.2ACE, REN, INS

Publications for Hyporeninemic Hypoaldosteronism

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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. (9627045)
1998
9
Accidental shock during epidural anesthesia in a patient with NSAID-induced hyporeninemic hypoaldosteronism. (9257212)
1997
10
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
11
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
12
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
13
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
14
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
15
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
16
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
17
A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]. (1607144)
1992
18
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
19
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia. (2543544)
1989
20
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
21
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
22
Hyperkalemic distal renal tubular acidosis with hyporeninemic hypoaldosteronism in a patient with systemic lupus erythematosus--a case report. (3441801)
1987
23
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
24
Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. (3515183)
1986
25
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
26
Hyporeninemic hypoaldosteronism in children with chronic renal failure. (3528445)
1986
27
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
28
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism. (3918448)
1985
29
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
30
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
31
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
32
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
33
Hyporeninemic hypoaldosteronism in infancy. (6353255)
1983
34
Hyporeninemic hypoaldosteronism, sodium wasting and mineralocorticoid-resistant hyperkalemia in two patients with obstructive uropathy. (6351617)
1983
35
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
36
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
37
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia. (6750425)
1982
38
Renal acidification in hyporeninemic hypoaldosteronism. (15171017)
1982
39
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
40
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
41
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. (6996036)
1980
42
Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. (6986536)
1980
43
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
44
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
45
Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. (591294)
1977
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse. (971018)
1976
48
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
49
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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Expression patterns in normal tissues for genes affiliated with Hyporeninemic Hypoaldosteronism

Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3REN, INS
2
Show member pathways
9.0REN, ACE
3
Show member pathways
8.5ACE, REN, INS
4
Show member pathways
8.5ACE, REN, INS
5
Show member pathways
8.5ACE, REN, INS

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate449.6INS, REN
2remikiren44 1210.5REN, ACE
3sampatrilat449.5ACE, REN
4ibopamine449.5REN, ACE
5alacepril449.5ACE, REN
6perindoprilat449.5ACE, REN
7aliskiren44 1210.5REN, ACE
8lacidipine449.5REN, ACE
9indapamide44 1210.5REN, ACE
10dihydralazine449.4REN, ACE
11bucindolol44 5010.4ACE, REN
12doxazosin44 1210.4ACE, INS
13saralasin449.4REN, ACE
14eprosartan44 29 1211.4ACE, REN
15bisoprolol44 50 1211.4ACE, REN
16omapatrilat449.4REN, ACE
17trandolapril44 1210.4REN, ACE
18cilazapril44 1210.4REN, ACE
19eplerenone44 60 29 1212.4ACE, REN
20fosinopril44 1210.4REN, ACE
21benazepril44 50 1211.4REN, ACE
22quinapril44 50 1211.4REN, ACE
23enalaprilat449.4REN, ACE
24lisinopril44 50 25 1212.4ACE, REN
25metoprolol44 50 29 25 1213.4ACE, REN
26chymostatin449.4REN, ACE
27hydralazine44 50 1211.4REN, ACE
28valsartan44 60 29 1212.4ACE, REN
29perindopril44 50 1211.4REN, ACE
30atenolol44 50 29 25 1213.3ACE, REN
31irbesartan44 29 50 1212.3ACE, REN
32felodipine44 29 1211.3ACE, REN
33dihydropyridine449.3ACE, REN
34candesartan44 50 29 1212.3ACE, REN
35diltiazem44 29 50 1212.2ACE, REN
36hydrochlorothiazide44 29 50 25 1213.2REN, ACE
37amlodipine44 50 25 1212.2ACE, REN
38enalapril44 50 1211.1REN, ACE
39spironolactone44 60 29 50 1213.1ACE, REN
40carvedilol44 50 29 1212.0REN, ACE
41digoxin44 60 50 25 1213.0ACE, REN
42olmesartan44 29 1211.0ACE, REN, INS
43moxonidine449.0INS, REN, ACE
44ramipril44 1210.0ACE, REN, INS
45thiazide449.0REN, INS, ACE
46telmisartan44 29 1211.0ACE, INS, REN
47nitroglycerin44 129.9REN, ACE
48norepinephrine44 25 1210.9ACE, REN, INS
49creatinine448.7INS, REN, ACE
50cholesterol44 29 25 1211.2INS, ACE, REN

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, REN, INS
2extracellular spaceGO:0056158.2ACE, REN, INS

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.0ACE, REN
2kidney developmentGO:0018229.0ACE, REN
3regulation of blood pressureGO:0082178.7ACE, REN
4cellular protein metabolic processGO:0442678.4ACE, REN, INS

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3REN, INS

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources for Hyporeninemic Hypoaldosteronism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet