MCID: HYP226
MIFTS: 32

Hyporeninemic Hypoaldosteronism malady

Rare diseases category

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Aliases & Descriptions for Hyporeninemic Hypoaldosteronism:

Name: Hyporeninemic Hypoaldosteronism 42
Hypoaldosteronism, Hyporeninemic 61
 
Hypoaldosteronism Hyporeninemic 44


Classifications:



Summaries for Hyporeninemic Hypoaldosteronism

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MalaCards based summary: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and glomerulosclerosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cyproteroneacetate and remikiren have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotypes are renal/urinary system and reproductive system.

Related Diseases for Hyporeninemic Hypoaldosteronism

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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism32.4REN
2glomerulosclerosis30.6ACE, REN
3autonomic neuropathy30.6REN, INS
4hypokalemia30.1INS, REN, ACE
5systemic lupus erythematosus10.5
6lupus erythematosus10.5
7multiple myeloma10.4
8glomerulonephritis10.4
9myeloma10.4
10fibromuscular dysplasia10.4REN
11hepatorenal syndrome10.4REN
12oligohydramnios10.3ACE
13chronic lymphocytic leukemia10.3
14leukemia10.3
15liver cirrhosis10.3
16renal tubular acidosis10.3
17addison's disease10.3
18metabolic acidosis10.3
19amyloidosis10.3
20kidney disease10.3
21lactic acidosis10.3
22nephrotic syndrome10.3
23neuropathy10.3
24sickle cell disease10.3
25acth deficiency10.3
26mental retardation10.3
27secondary amyloidosis10.3
28cushing's syndrome10.1REN, INS
29idiopathic edema10.0INS, ACE
30cork-handlers' disease10.0INS, ACE
31renal tubular dysgenesis10.0ACE, REN
32malignant hypertension10.0ACE, REN
33hypertension, diastolic10.0REN, ACE
34microvascular complications of diabetes 510.0ACE, INS
35renovascular hypertension10.0REN, ACE
36renal hypertension10.0REN, ACE
37lipid metabolism disorder10.0INS, ACE
38pure autonomic failure10.0REN, ACE
39familial hyperlipidemia10.0INS, ACE
40hyperaldosteronism10.0REN, ACE
41hypercholesterolemia, familial10.0INS, ACE
42polycystic kidney disease, autosomal dominant10.0REN, ACE
43diabetes mellitus, insulin-dependent10.0ACE, INS
44congestive heart failure10.0ACE, REN
45vascular disease9.9INS, ACE
46hyperglycemia9.9INS, ACE
47coronary artery disease9.9ACE, INS
48primary hyperoxaluria9.9REN, ACE
49diabetes mellitus, noninsulin-dependent9.9INS, ACE
50congenital heart disease9.8ACE, REN

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Symptoms for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

31
Kidney, Liver

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, REN, INS
2MP:00053898.6INS, REN, ACE
3MP:00053858.5ACE, REN, INS
4MP:00053878.5ACE, REN, INS
5MP:00053978.4INS, REN, ACE
6MP:00053868.2ACE, REN, INS

Publications for Hyporeninemic Hypoaldosteronism

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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Prerenal azotemia in a diabetic patient with hyporeninemic hypoaldosteronism and autonomic neuropathy. (10566125)
1999
9
Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. (9627045)
1998
10
Accidental shock during epidural anesthesia in a patient with NSAID-induced hyporeninemic hypoaldosteronism. (9257212)
1997
11
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
12
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
13
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
14
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
15
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
16
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
17
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
18
A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]. (1607144)
1992
19
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
20
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia. (2543544)
1989
21
Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. (3394721)
1988
22
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
23
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
24
Hyperkalemic distal renal tubular acidosis with hyporeninemic hypoaldosteronism in a patient with systemic lupus erythematosus--a case report. (3441801)
1987
25
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
26
Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. (3515183)
1986
27
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
28
Hyporeninemic hypoaldosteronism in children with chronic renal failure. (3528445)
1986
29
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
30
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism. (3918448)
1985
31
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
32
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
33
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
34
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
35
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
36
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
37
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia. (6750425)
1982
38
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
39
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
40
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. (6996036)
1980
41
Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. (6986536)
1980
42
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
43
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
44
Hyporeninemic hypoaldosteronism--case report and observation of dissociated renin and erythropoietin activity. (670540)
1978
45
Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. (591294)
1977
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse. (971018)
1976
48
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
49
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0REN, ACE
2
Show member pathways
8.5ACE, REN, INS
3
Show member pathways
8.5ACE, REN, INS
4
Show member pathways
8.5ACE, REN, INS

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate449.6INS, REN
2remikiren44 1110.5REN, ACE
3sampatrilat449.5ACE, REN
4ibopamine449.5REN, ACE
5alacepril449.5ACE, REN
6perindoprilat449.5ACE, REN
7aliskiren44 1110.5REN, ACE
8lacidipine449.5REN, ACE
9indapamide44 1110.5REN, ACE
10dihydralazine449.4REN, ACE
11bucindolol44 5010.4ACE, REN
12doxazosin44 1110.4ACE, INS
13saralasin449.4REN, ACE
14eprosartan44 28 1111.4ACE, REN
15bisoprolol44 50 1111.4ACE, REN
16omapatrilat449.4REN, ACE
17trandolapril44 1110.4REN, ACE
18cilazapril44 1110.4REN, ACE
19eplerenone44 60 28 1112.4ACE, REN
20fosinopril44 1110.4REN, ACE
21benazepril44 50 1111.4REN, ACE
22quinapril44 50 1111.4REN, ACE
23enalaprilat449.4REN, ACE
24lisinopril44 50 24 1112.4ACE, REN
25metoprolol44 50 28 24 1113.4ACE, REN
26chymostatin449.4REN, ACE
27hydralazine44 50 1111.4REN, ACE
28valsartan44 60 28 1112.4ACE, REN
29perindopril44 50 1111.4REN, ACE
30atenolol44 50 28 24 1113.3ACE, REN
31irbesartan44 28 50 1112.3ACE, REN
32felodipine44 28 1111.3ACE, REN
33dihydropyridine449.3ACE, REN
34candesartan44 50 28 1112.3ACE, REN
35diltiazem44 28 50 1112.2ACE, REN
36hydrochlorothiazide44 28 50 24 1113.2REN, ACE
37amlodipine44 50 24 1112.2ACE, REN
38enalapril44 50 1111.1REN, ACE
39spironolactone44 60 28 50 1113.1ACE, REN
40carvedilol44 50 28 1112.0REN, ACE
41digoxin44 60 50 24 1113.0ACE, REN
42olmesartan44 28 1111.0ACE, REN, INS
43moxonidine449.0INS, REN, ACE
44ramipril44 1110.0ACE, REN, INS
45thiazide449.0REN, INS, ACE
46telmisartan44 28 1111.0ACE, INS, REN
47nitroglycerin44 119.9REN, ACE
48norepinephrine44 24 1110.9ACE, REN, INS
49creatinine448.7INS, REN, ACE
50cholesterol44 28 24 1111.2INS, ACE, REN

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5ACE, REN, INS
2extracellular spaceGO:00056158.2ACE, REN, INS

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:00020039.0ACE, REN
2kidney developmentGO:00018229.0ACE, REN
3regulation of blood pressureGO:00082178.7ACE, REN
4cellular protein metabolic processGO:00442678.4ACE, REN, INS

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00051599.3REN, INS

Sources for Hyporeninemic Hypoaldosteronism

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet