MCID: HYP226
MIFTS: 33

Hyporeninemic Hypoaldosteronism malady

Summaries for Hyporeninemic Hypoaldosteronism

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33MalaCards
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MalaCards: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and metabolic acidosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cilazapril and cyproteroneacetate have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

hyporeninemic hypoaldosteronism 43
hypoaldosteronism, hyporeninemic 61
hypoaldosteronism hyporeninemic 45


Related Diseases for Hyporeninemic Hypoaldosteronism

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism31.7REN
2metabolic acidosis30.3REN
3autonomic neuropathy30.3INS, REN
4hypokalemia30.3REN, INS, ACE
5diabetic nephropathy30.3ACE, INS, REN
6systemic lupus erythematosus10.5
7liddle syndrome10.2
8renal tubular acidosis10.2
9n syndrome10.2
10diabetic autonomic neuropathy10.2
11amyloidosis10.2
12sickle cell disease10.2
13isolated acth deficiency10.2
14renal tubular acidosis, distal10.2
15acth deficiency10.2
16mental retardation10.2
17amyloidosis, secondary10.2
18hyperkalemic renal tubular acidosis10.2
19morbid obesity10.0INS
20diarrhea10.0INS
21hypothyroidism10.0INS
22polycystic ovary syndrome10.0INS
23peripheral vascular disease10.0INS
24blindness10.0INS
25cystic fibrosis10.0INS
26neuropathy10.0INS
27ovarian hyperstimulation syndrome10.0REN
28portal hypertension10.0REN
29hyperuricemia10.0INS
30galactosemia10.0INS
31fibromuscular dysplasia10.0REN
32hepatorenal syndrome10.0REN
33hyperandrogenism10.0INS
34liver cirrhosis10.0REN
35growth hormone deficiency10.0INS
36adrenal adenoma10.0REN
37glucose intolerance10.0INS
38acromegaly10.0INS
39addison's disease10.0REN
40hypertriglyceridemia10.0INS
41cerebrovascular disease10.0ACE
42obesity10.0INS
43anuria10.0ACE
44nephrotic syndrome10.0ACE
45acute myocardial infarction10.0ACE
46nephrosclerosis10.0ACE
47oligohydramnios10.0ACE
48dilated cardiomyopathy10.0ACE
49systemic scleroderma10.0ACE
50deficiency anemia10.0ACE

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Clinical Features for Hyporeninemic Hypoaldosteronism

Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

Anatomical Context for Hyporeninemic Hypoaldosteronism

Sources:
33MalaCards
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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

33
Kidney, Liver

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5ACE, INS, REN

Publications for Hyporeninemic Hypoaldosteronism

Sources:
51PubMed
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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Treatment for hyperkalemia in hyporeninemic hypoaldosteronism. (19404283)
2009
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Prerenal azotemia in a diabetic patient with hyporeninemic hypoaldosteronism and autonomic neuropathy. (10566125)
1999
9
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
10
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
11
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
12
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
13
Mechanisms of hyperkalemia associated with hyporeninemic hypoaldosteronism in streptozotocin-induced diabetic rats. (7986385)
1994
14
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
15
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
16
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
17
Hyperkalemia due to hyporeninemic hypoaldosteronism with liver cirrhosis and hypertension. (8179835)
1993
18
Studies on the cause and the treatment of hyporeninemic selected hypoaldosteronism in diabetic nephropathy. (1798229)
1991
19
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
20
Plasma 18-hydroxycorticosterone and aldosterone responses to angiotensin II and corticotropin in diabetic patients with hyporeninemic and normoreninemic hypoaldosteronism. (2545066)
1989
21
Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. (3394721)
1988
22
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
23
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
24
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
25
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
26
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
27
Hyperkalemic left bundle branch block and hyporeninemic hypoaldosteronism (hyperkalemic left bundle branch block). (3543195)
1986
28
Systemic lupus erythematosus presenting with hyporeninemic hypoaldosteronism in a 10-year-old girl. (3535507)
1986
29
Hyporeninemic hypoaldosteronism. (3515186)
1986
30
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
31
Hyporeninemic hypoaldosteronism. New associations. (3896183)
1985
32
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
33
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
34
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
35
Hyporeninemic hypoaldosteronism in a patient with multiple myeloma. (6383030)
1984
36
Hyporeninemic hypoaldosteronism, sodium wasting and mineralocorticoid-resistant hyperkalemia in two patients with obstructive uropathy. (6351617)
1983
37
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
38
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
39
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
40
Inactive renin and prostaglandin E2 production in hyporeninemic hypoaldosteronism. (6998998)
1980
41
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
42
Hyporeninemic hypoaldosteronism in diabetes mellitus. Studies of the autonomic nervous system's control of renin release. (446908)
1979
43
Hyporeninemic hypoaldosteronism. (34320)
1979
44
The syndrome of hyporeninemic hypoaldosteronism. (400485)
1979
45
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
48
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
49
A mechanism for hyporeninemic hypoaldosteronism in chronic renal disease. (4372510)
1974
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Genetic Variations for Hyporeninemic Hypoaldosteronism

Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyporeninemic Hypoaldosteronism

Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

Sources:
12EMD Millipore, 50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN
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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, REN
2
Hide members
9.0ACE, REN
3
Hide members
8.5ACE, INS, REN
4
Hide members
8.5ACE, INS, REN
5
Hide members
8.5REN, INS, ACE

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1cilazapril45 1111.0ACE
2cyproteroneacetate459.6REN, INS
3captopril45 29 50 60 1113.6REN
4sampatrilat459.5REN, ACE
5remikiren45 1110.5REN, ACE
6ibopamine459.5ACE, REN
7perindoprilat459.5REN, ACE
8alacepril459.5ACE, REN
9aliskiren45 1110.5ACE, REN
10dihydralazine459.5ACE, REN
11indapamide45 1110.5REN, ACE
12doxazosin45 1110.5ACE, INS
13lacidipine459.4ACE, REN
14bucindolol50 4510.4REN, ACE
15saralasin459.4REN, ACE
16benazepril45 1110.4ACE, REN
17eprosartan45 29 1111.4ACE, REN
18bisoprolol45 50 1111.4ACE, REN
19omapatrilat459.4REN, ACE
20trandolapril45 1110.4ACE, REN
21fosinopril45 1110.4ACE, REN
22eplerenone45 60 29 1112.4ACE, REN
23quinapril45 1110.4ACE, REN
24enalaprilat459.4ACE, REN
25lisinopril45 11 2411.4REN, ACE
26metoprolol45 29 50 11 2413.4ACE, REN
27chymostatin459.4REN, ACE
28atenolol45 29 50 11 2413.4ACE, REN
29valsartan45 60 29 1112.4ACE, REN
30perindopril45 50 1111.4REN, ACE
31irbesartan45 29 50 1112.3ACE, REN
32felodipine45 29 1111.3ACE, REN
33dihydropyridine459.3ACE, REN
34hydrochlorothiazide45 50 29 11 2413.3REN, ACE
35diltiazem45 29 1111.3REN, ACE
36candesartan45 29 1111.3ACE, REN
37enalapril45 50 1111.3ACE, REN
38spironolactone50 45 60 29 1113.2REN, ACE
39amlodipine45 50 11 2412.2REN, ACE
40carvedilol45 50 29 1112.2ACE, REN
41nitroglycerin45 1110.1ACE, REN
42furosemide45 50 60 29 11 2414.0REN, ACE
43ang ii459.0REN, ACE
44olmesartan45 29 1111.0REN, INS, ACE
45moxonidine459.0REN, INS, ACE
46ramipril45 1110.0REN, INS, ACE
47thiazide459.0REN, ACE, INS
48telmisartan45 29 1111.0INS, ACE, REN
49digoxin45 50 60 11 2412.9REN, ACE
50creatinine458.6REN, ACE, INS

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

Sources:
16Gene Ontology
See all sources

Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, INS, REN
2extracellular spaceGO:0056158.2ACE, INS, REN

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.0ACE, REN
2kidney developmentGO:0018229.0ACE, REN
3regulation of blood pressureGO:0082178.7ACE, REN
4cellular protein metabolic processGO:0442678.4ACE, INS, REN

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3INS, REN

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyporeninemic Hypoaldosteronism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet