MCID: HYP226
MIFTS: 39

Hyporeninemic Hypoaldosteronism malady

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Summaries for Hyporeninemic Hypoaldosteronism

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

MalaCards: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and glomerulosclerosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cyproteroneacetate and sampatrilat have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and kidney, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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43NIH Rare Diseases, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

hyporeninemic hypoaldosteronism 43
hypoaldosteronism, hyporeninemic 62
hypoaldosteronism hyporeninemic 45


Related Diseases for Hyporeninemic Hypoaldosteronism

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17GeneCards, 18GeneDecks
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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism31.9REN
2glomerulosclerosis30.6ACE, REN
3hypertension30.5INS, REN, ACE
4diabetes mellitus30.5ACE, REN, INS
5autonomic neuropathy30.4INS, REN
6hypokalemia30.3ACE, REN, INS
7diabetic nephropathy30.3INS, REN, ACE
8systemic lupus erythematosus10.5
9lupus erythematosus10.5
10glomerulonephritis10.4
11multiple myeloma10.4
12myeloma10.4
13addison's disease10.2
14metabolic acidosis10.2
15renal tubular acidosis10.2
16amyloidosis10.2
17chronic lymphocytic leukemia10.2
18kidney disease10.2
19lactic acidosis10.2
20leukemia10.2
21liver cirrhosis10.2
22nephrotic syndrome10.2
23neuropathy10.2
24sickle cell disease10.2
25isolated acth deficiency10.2
26acth deficiency10.2
27mental retardation10.2
28fibromuscular dysplasia10.1REN
29hepatorenal syndrome10.1REN
30oligohydramnios10.1ACE
31cushing's syndrome10.0REN, INS
32idiopathic edema10.0ACE, INS
33cork-handlers' disease10.0ACE, INS
34malignant hypertension10.0REN, ACE
35hypertension, diastolic10.0REN, ACE
36renal tubular dysgenesis10.0REN, ACE
37diabetic retinopathy10.0INS, ACE
38renovascular hypertension10.0ACE, REN
39renal hypertension10.0ACE, REN
40familial hyperlipidemia10.0ACE, INS
41pure autonomic failure10.0REN, ACE
42hypercholesterolemia10.0INS, ACE
43hyperaldosteronism10.0REN, ACE
44type 1 diabetes mellitus10.0ACE, INS
45polycystic kidney disease, autosomal dominant10.0ACE, REN
46congestive heart failure10.0ACE, REN
47vascular disease10.0ACE, INS
48hyperglycemia10.0INS, ACE
49coronary artery disease10.0ACE, INS
50primary hyperoxaluria10.0ACE, REN

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Symptoms for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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33MalaCards
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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

33
Adrenal gland, Liver, Kidney

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, REN, INS
2MP:00053898.6INS, REN, ACE
3MP:00053858.5ACE, REN, INS
4MP:00053878.5ACE, REN, INS
5MP:00053978.4INS, REN, ACE
6MP:00053868.2ACE, REN, INS

Publications for Hyporeninemic Hypoaldosteronism

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Sources:
52PubMed
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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Prerenal azotemia in a diabetic patient with hyporeninemic hypoaldosteronism and autonomic neuropathy. (10566125)
1999
9
Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. (9627045)
1998
10
Accidental shock during epidural anesthesia in a patient with NSAID-induced hyporeninemic hypoaldosteronism. (9257212)
1997
11
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
12
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
13
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
14
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
15
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
16
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
17
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
18
A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]. (1607144)
1992
19
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
20
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia. (2543544)
1989
21
Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. (3394721)
1988
22
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
23
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
24
Hyperkalemic distal renal tubular acidosis with hyporeninemic hypoaldosteronism in a patient with systemic lupus erythematosus--a case report. (3441801)
1987
25
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
26
Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. (3515183)
1986
27
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
28
Hyporeninemic hypoaldosteronism in children with chronic renal failure. (3528445)
1986
29
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
30
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism. (3918448)
1985
31
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
32
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
33
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
34
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
35
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
36
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
37
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia. (6750425)
1982
38
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
39
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
40
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. (6996036)
1980
41
Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. (6986536)
1980
42
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
43
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
44
Hyporeninemic hypoaldosteronism--case report and observation of dissociated renin and erythropoietin activity. (670540)
1978
45
Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. (591294)
1977
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse. (971018)
1976
48
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
49
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyporeninemic Hypoaldosteronism

Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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50PathCards, 12EMD Millipore, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome
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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3REN, INS
2
Show member pathways
9.0REN, ACE
3
Show member pathways
8.5ACE, REN, INS
4
Show member pathways
8.5ACE, REN, INS
5
Show member pathways
8.5ACE, REN, INS

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate459.6INS, REN
2sampatrilat459.5REN, ACE
3ibopamine459.5REN, ACE
4remikiren45 1110.5REN, ACE
5perindoprilat459.5REN, ACE
6alacepril459.5REN, ACE
7aliskiren45 1110.5ACE, REN
8bucindolol45 5110.5REN, ACE
9dihydralazine459.5REN, ACE
10indapamide45 1110.4REN, ACE
11lacidipine459.4REN, ACE
12doxazosin45 1110.4ACE, INS
13saralasin459.4ACE, REN
14eprosartan45 29 1111.4REN, ACE
15bisoprolol45 51 1111.4REN, ACE
16omapatrilat459.4REN, ACE
17cilazapril45 1110.4REN, ACE
18trandolapril45 1110.4REN, ACE
19eplerenone45 61 29 1112.4REN, ACE
20fosinopril45 1110.4REN, ACE
21benazepril45 51 1111.4ACE, REN
22enalaprilat459.4REN, ACE
23quinapril45 51 1111.4REN, ACE
24metoprolol45 51 29 24 1113.4REN, ACE
25lisinopril45 51 24 1112.4REN, ACE
26chymostatin459.4ACE, REN
27hydralazine45 51 1111.4REN, ACE
28valsartan45 61 29 1112.4REN, ACE
29perindopril45 51 1111.4ACE, REN
30atenolol45 51 29 24 1113.3REN, ACE
31irbesartan45 29 51 1112.3ACE, REN
32felodipine45 29 1111.3ACE, REN
33dihydropyridine459.3ACE, REN
34diltiazem45 29 51 1112.3REN, ACE
35candesartan45 51 29 1112.2REN, ACE
36hydrochlorothiazide45 29 51 24 1113.2ACE, REN
37spironolactone45 61 29 51 1113.2REN, ACE
38amlodipine45 51 24 1112.1REN, ACE
39enalapril45 51 1111.1REN, ACE
40carvedilol45 51 29 1112.0ACE, REN
41digoxin45 61 51 24 1113.0ACE, REN
42olmesartan45 29 1111.0ACE, INS, REN
43moxonidine459.0INS, REN, ACE
44ramipril45 1110.0ACE, REN, INS
45thiazide459.0INS, REN, ACE
46telmisartan45 29 1111.0ACE, REN, INS
47nitroglycerin45 119.9REN, ACE
48norepinephrine45 24 1110.9ACE, REN, INS
49creatinine458.7ACE, REN, INS
50cholesterol45 29 24 1111.2ACE, REN, INS

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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16Gene Ontology
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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, REN, INS
2extracellular spaceGO:0056158.2ACE, REN, INS

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.0ACE, REN
2kidney developmentGO:0018229.0ACE, REN
3regulation of blood pressureGO:0082178.7ACE, REN
4cellular protein metabolic processGO:0442678.4ACE, REN, INS

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3REN, INS

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

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  • Antibodies
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Sources for Hyporeninemic Hypoaldosteronism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet