MCID: HYP226
MIFTS: 27

Hyporeninemic Hypoaldosteronism malady

Summaries for Hyporeninemic Hypoaldosteronism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

MalaCards: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to diabetes mellitus and hypertension. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cilazapril and cyproteroneacetate have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

hyporeninemic hypoaldosteronism 42
hypoaldosteronism, hyporeninemic 60
hypoaldosteronism hyporeninemic 44


Related Diseases for Hyporeninemic Hypoaldosteronism

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17GeneCards, 18GeneDecks
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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.5ACE, REN, INS
2hypertension30.5ACE, INS, REN
3hypoaldosteronism30.3REN
4neuropathy30.3INS
5metabolic acidosis30.3REN
6liver cirrhosis30.3REN
7addison's disease30.3REN
8nephrotic syndrome30.3ACE
9autonomic neuropathy30.3INS, REN
10hypokalemia30.2REN, INS, ACE
11diabetic nephropathy30.2ACE, INS, REN
12systemic lupus erythematosus10.4
13lupus erythematosus10.4
14glomerulonephritis10.4
15multiple myeloma10.4
16myeloma10.4
17renal tubular acidosis10.2
18diabetic autonomic neuropathy10.2
19amyloidosis10.2
20chronic lymphocytic leukemia10.2
21diabetic neuropathy10.2
22kidney disease10.2
23lactic acidosis10.2
24leukemia10.2
25sickle cell disease10.2
26morbid obesity10.0INS
27diarrhea10.0INS
28hypothyroidism10.0INS
29polycystic ovary syndrome10.0INS
30peripheral vascular disease10.0INS
31blindness10.0INS
32cystic fibrosis10.0INS
33ovarian hyperstimulation syndrome10.0REN
34portal hypertension10.0REN
35hyperuricemia10.0INS
36galactosemia10.0INS
37fibromuscular dysplasia10.0REN
38hepatorenal syndrome10.0REN
39hyperandrogenism10.0INS
40growth hormone deficiency10.0INS
41adrenal adenoma10.0REN
42glucose intolerance10.0INS
43acromegaly10.0INS
44hypertriglyceridemia10.0INS
45cerebrovascular disease10.0ACE
46obesity10.0INS
47anuria10.0ACE
48acute myocardial infarction10.0ACE
49nephrosclerosis10.0ACE
50oligohydramnios10.0ACE

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Clinical Features for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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32MalaCards
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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

32
Adrenal gland

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5ACE, INS, REN

Publications for Hyporeninemic Hypoaldosteronism

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Genetic Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyporeninemic Hypoaldosteronism

Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources:
12EMD Millipore, 49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, REN
2
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9.0REN, ACE
3
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8.5REN, INS, ACE
4
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8.5REN, INS, ACE
5
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8.5REN, INS, ACE

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1cilazapril44 1111.0ACE
2cyproteroneacetate449.6REN, INS
3captopril44 28 49 59 1113.6REN
4sampatrilat449.5REN, ACE
5remikiren44 1110.5REN, ACE
6ibopamine449.5ACE, REN
7perindoprilat449.5REN, ACE
8alacepril449.5ACE, REN
9aliskiren44 1110.5ACE, REN
10dihydralazine449.5ACE, REN
11indapamide44 1110.5REN, ACE
12doxazosin44 1110.5ACE, INS
13lacidipine449.4ACE, REN
14bucindolol49 4410.4REN, ACE
15saralasin449.4REN, ACE
16benazepril44 1110.4ACE, REN
17eprosartan44 28 1111.4ACE, REN
18bisoprolol44 49 1111.4ACE, REN
19omapatrilat449.4REN, ACE
20trandolapril44 1110.4ACE, REN
21fosinopril44 1110.4ACE, REN
22eplerenone44 59 28 1112.4ACE, REN
23quinapril44 1110.4ACE, REN
24enalaprilat449.4ACE, REN
25lisinopril44 11 2411.4REN, ACE
26metoprolol44 28 49 11 2413.4ACE, REN
27chymostatin449.4REN, ACE
28atenolol44 28 49 11 2413.4ACE, REN
29valsartan44 59 28 1112.4ACE, REN
30perindopril44 49 1111.4REN, ACE
31irbesartan44 28 49 1112.3ACE, REN
32felodipine44 28 1111.3ACE, REN
33dihydropyridine449.3ACE, REN
34hydrochlorothiazide44 49 28 11 2413.3REN, ACE
35diltiazem44 28 1111.3REN, ACE
36candesartan44 28 1111.3ACE, REN
37enalapril44 49 1111.3ACE, REN
38spironolactone49 44 59 28 1113.2REN, ACE
39amlodipine44 49 11 2412.2REN, ACE
40carvedilol44 49 28 1112.2ACE, REN
41nitroglycerin44 1110.1ACE, REN
42furosemide44 49 59 28 11 2414.0REN, ACE
43ang ii449.0REN, ACE
44olmesartan44 28 1111.0REN, INS, ACE
45moxonidine449.0REN, INS, ACE
46ramipril44 1110.0REN, INS, ACE
47thiazide449.0REN, ACE, INS
48telmisartan44 28 1111.0INS, ACE, REN
49digoxin44 49 59 11 2412.9REN, ACE
50creatinine448.6REN, ACE, INS

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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16Gene Ontology
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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, INS, REN
2extracellular spaceGO:0056158.2ACE, INS, REN

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.0ACE, REN
2kidney developmentGO:0018229.0ACE, REN
3regulation of blood pressureGO:0082178.7ACE, REN
4cellular protein metabolic processGO:0442678.4ACE, INS, REN

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3INS, REN

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hyporeninemic Hypoaldosteronism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet