MCID: HYP226
MIFTS: 39

Hyporeninemic Hypoaldosteronism malady

Rare diseases category

Summaries for Hyporeninemic Hypoaldosteronism

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced... more...

MalaCards: Hyporeninemic Hypoaldosteronism, also known as hypoaldosteronism, hyporeninemic, is related to hypoaldosteronism and glomerulosclerosis. An important gene associated with Hyporeninemic Hypoaldosteronism is REN (renin), and among its related pathways are Selected targets of CREB1 and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds cyproteroneacetate and sampatrilat have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and kidney, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Hyporeninemic Hypoaldosteronism

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44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

hyporeninemic hypoaldosteronism 44
hypoaldosteronism, hyporeninemic 63
hypoaldosteronism hyporeninemic 46


Related Diseases for Hyporeninemic Hypoaldosteronism

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hyporeninemic Hypoaldosteronism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism31.9REN
2glomerulosclerosis30.6ACE, REN
3hypertension30.5INS, REN, ACE
4diabetes mellitus30.5ACE, REN, INS
5autonomic neuropathy30.4INS, REN
6hypokalemia30.3ACE, REN, INS
7diabetic nephropathy30.3INS, REN, ACE
8systemic lupus erythematosus10.5
9lupus erythematosus10.5
10glomerulonephritis10.4
11multiple myeloma10.4
12myeloma10.4
13addison's disease10.2
14metabolic acidosis10.2
15renal tubular acidosis10.2
16amyloidosis10.2
17chronic lymphocytic leukemia10.2
18kidney disease10.2
19lactic acidosis10.2
20leukemia10.2
21liver cirrhosis10.2
22nephrotic syndrome10.2
23neuropathy10.2
24sickle cell disease10.2
25isolated acth deficiency10.2
26acth deficiency10.2
27mental retardation10.2
28fibromuscular dysplasia10.1REN
29hepatorenal syndrome10.1REN
30oligohydramnios10.1ACE
31cushing's syndrome10.0REN, INS
32idiopathic edema10.0ACE, INS
33cork-handlers' disease10.0ACE, INS
34malignant hypertension10.0REN, ACE
35hypertension, diastolic10.0REN, ACE
36renal tubular dysgenesis10.0REN, ACE
37diabetic retinopathy10.0INS, ACE
38renovascular hypertension10.0ACE, REN
39renal hypertension10.0ACE, REN
40familial hyperlipidemia10.0ACE, INS
41pure autonomic failure10.0REN, ACE
42hypercholesterolemia10.0INS, ACE
43hyperaldosteronism10.0REN, ACE
44type 1 diabetes mellitus10.0ACE, INS
45polycystic kidney disease, autosomal dominant10.0ACE, REN
46congestive heart failure10.0ACE, REN
47vascular disease10.0ACE, INS
48hyperglycemia10.0INS, ACE
49coronary artery disease10.0ACE, INS
50primary hyperoxaluria10.0ACE, REN

Graphical network of the top 20 diseases related to Hyporeninemic Hypoaldosteronism:



Diseases related to hyporeninemic hypoaldosteronism

Symptoms for Hyporeninemic Hypoaldosteronism

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Drugs & Therapeutics for Hyporeninemic Hypoaldosteronism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Drug clinical trials:

Search ClinicalTrials for Hyporeninemic Hypoaldosteronism

Search NIH Clinical Center for Hyporeninemic Hypoaldosteronism

Search CenterWatch for Hyporeninemic Hypoaldosteronism

Genetic Tests for Hyporeninemic Hypoaldosteronism

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Anatomical Context for Hyporeninemic Hypoaldosteronism

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34MalaCards
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MalaCards organs/tissues related to Hyporeninemic Hypoaldosteronism:

34
Adrenal gland, Liver, Kidney

Animal Models for Hyporeninemic Hypoaldosteronism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hyporeninemic Hypoaldosteronism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, REN, INS
2MP:00053898.6INS, REN, ACE
3MP:00053858.5ACE, REN, INS
4MP:00053878.5ACE, REN, INS
5MP:00053978.4INS, REN, ACE
6MP:00053868.2ACE, REN, INS

Publications for Hyporeninemic Hypoaldosteronism

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Sources:
53PubMed
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Articles related to Hyporeninemic Hypoaldosteronism:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism. (23295301)
2012
2
A case of hyporeninemic hypoaldosteronism in the dog. (21696443)
2011
3
Hyporeninemic hypoaldosteronism in a child with chronic kidney disease--is this condition renoprotective? (19189133)
2009
4
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
5
Transient hyporeninemic hypoaldosteronism in acute glomerulonephritis. (12432442)
2002
6
Hyporeninemic hypoaldosteronism associated with SjAPgren's syndrome. (11893359)
2002
7
Prominent medial hypertrophy of renal arterioles in an infant with hyporeninemic hypoaldosteronism. (10353411)
1999
8
Prerenal azotemia in a diabetic patient with hyporeninemic hypoaldosteronism and autonomic neuropathy. (10566125)
1999
9
Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. (9627045)
1998
10
Accidental shock during epidural anesthesia in a patient with NSAID-induced hyporeninemic hypoaldosteronism. (9257212)
1997
11
Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]. (8928409)
1996
12
A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism. (8773360)
1996
13
Reversible hyperkalemia at the initiation of ACE inhibitors in a young diabetic patient with latent hyporeninemic hypoaldosteronism. (8799646)
1996
14
The effect of long-term treatment of arterial hypertension with Ca antagonists on the renin-angiotensin-aldosterone system in diabetics. Hyporeninemic hypoaldosteronism]. (8578695)
1995
15
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
16
Effect of glycyrrhizine on hyperkalemia due to hyporeninemic hypoaldosteronism in diabetes mellitus. (8336514)
1993
17
Hyporeninemic hypoaldosteronism complicating primary autonomic insufficiency. (8212689)
1993
18
A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]. (1607144)
1992
19
Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism. (2074657)
1990
20
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia. (2543544)
1989
21
Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. (3394721)
1988
22
Hyporeninemic hypoaldosteronism presenting with hypokalemia. (3281049)
1988
23
Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. (3398981)
1988
24
Hyperkalemic distal renal tubular acidosis with hyporeninemic hypoaldosteronism in a patient with systemic lupus erythematosus--a case report. (3441801)
1987
25
Hyporeninemic hypoaldosteronism associated with acquired immune deficiency syndrome. (3555065)
1987
26
Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. (3515183)
1986
27
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
28
Hyporeninemic hypoaldosteronism in children with chronic renal failure. (3528445)
1986
29
Hyporeninemic hypoaldosteronism in a patient with cirrhosis and ascites. (3535721)
1986
30
IgM monoclonal gammopathy accompanied by nodular glomerulosclerosis, urine-concentrating defect, and hyporeninemic hypoaldosteronism. (3918448)
1985
31
Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic hypoaldosteronism. (2987296)
1985
32
The syndrome of hyporeninemic hypoaldosteronism. (6387040)
1984
33
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. (6377883)
1984
34
Hyporeninemic hypoaldosteronism in infancy: a familial disease. (6315756)
1984
35
Hyporeninemic hypoaldosteronism in sickle cell disease. (6750423)
1982
36
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
37
Hyporeninemic hypoaldosteronism associated with focal glomerular sclerosis in a patient with chronic lymphocytic leukemia. (6750425)
1982
38
Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism. (6267637)
1981
39
Mineralocorticoid biosynthesis in patients with hyporeninemic hypoaldosteronism. (6986396)
1980
40
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. (6996036)
1980
41
Pathophysiology of the syndrome of hyporeninemic hypoaldosteronism. (6986536)
1980
42
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. (434681)
1979
43
Control of plasma aldosterone in diabetic patients with hyporeninemic hypoaldosteronism. (204828)
1978
44
Hyporeninemic hypoaldosteronism--case report and observation of dissociated renin and erythropoietin activity. (670540)
1978
45
Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. (591294)
1977
46
Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism. (865654)
1977
47
Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse. (971018)
1976
48
Letter: Hyporeninemic hypoaldosteronism in chronic renal disease. (1128240)
1975
49
Hyporeninemic hypoaldosteronism with diabetic glomerulosclerosis. (174560)
1975
50
Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. (4349050)
1973

Variations for Hyporeninemic Hypoaldosteronism

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Expression for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hyporeninemic Hypoaldosteronism

Search GEO for disease gene expression data for Hyporeninemic Hypoaldosteronism.

Pathways for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources:
51PathCards, 13EMD Millipore, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome
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Pathways related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3REN, INS
2
Show member pathways
9.0REN, ACE
3
Show member pathways
8.5ACE, REN, INS
4
Show member pathways
8.5ACE, REN, INS
5
Show member pathways
8.5ACE, REN, INS

Compounds for genes affiliated with Hyporeninemic Hypoaldosteronism

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cyproteroneacetate469.6INS, REN
2sampatrilat469.5REN, ACE
3ibopamine469.5REN, ACE
4remikiren46 1210.5REN, ACE
5perindoprilat469.5REN, ACE
6alacepril469.5REN, ACE
7aliskiren46 1210.5ACE, REN
8bucindolol46 5210.5REN, ACE
9dihydralazine469.5REN, ACE
10indapamide46 1210.4REN, ACE
11lacidipine469.4REN, ACE
12doxazosin46 1210.4ACE, INS
13saralasin469.4ACE, REN
14eprosartan46 30 1211.4REN, ACE
15bisoprolol46 52 1211.4REN, ACE
16omapatrilat469.4REN, ACE
17cilazapril46 1210.4REN, ACE
18trandolapril46 1210.4REN, ACE
19eplerenone46 62 30 1212.4REN, ACE
20fosinopril46 1210.4REN, ACE
21benazepril46 52 1211.4ACE, REN
22enalaprilat469.4REN, ACE
23quinapril46 52 1211.4REN, ACE
24metoprolol46 52 30 25 1213.4REN, ACE
25lisinopril46 52 25 1212.4REN, ACE
26chymostatin469.4ACE, REN
27hydralazine46 52 1211.4REN, ACE
28valsartan46 62 30 1212.4REN, ACE
29perindopril46 52 1211.4ACE, REN
30atenolol46 52 30 25 1213.3REN, ACE
31irbesartan46 30 52 1212.3ACE, REN
32felodipine46 30 1211.3ACE, REN
33dihydropyridine469.3ACE, REN
34diltiazem46 30 52 1212.3REN, ACE
35candesartan46 52 30 1212.2REN, ACE
36hydrochlorothiazide46 30 52 25 1213.2ACE, REN
37spironolactone46 62 30 52 1213.2REN, ACE
38amlodipine46 52 25 1212.1REN, ACE
39enalapril46 52 1211.1REN, ACE
40carvedilol46 52 30 1212.0ACE, REN
41digoxin46 62 52 25 1213.0ACE, REN
42olmesartan46 30 1211.0ACE, INS, REN
43moxonidine469.0INS, REN, ACE
44ramipril46 1210.0ACE, REN, INS
45thiazide469.0INS, REN, ACE
46telmisartan46 30 1211.0ACE, REN, INS
47nitroglycerin46 129.9REN, ACE
48norepinephrine46 25 1210.9ACE, REN, INS
49creatinine468.7ACE, REN, INS
50cholesterol46 30 25 1211.2ACE, REN, INS

GO Terms for genes affiliated with Hyporeninemic Hypoaldosteronism

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17Gene Ontology
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Cellular components related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ACE, REN, INS
2extracellular spaceGO:0056158.2ACE, REN, INS

Biological processes related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.0ACE, REN
2kidney developmentGO:0018229.0ACE, REN
3regulation of blood pressureGO:0082178.7ACE, REN
4cellular protein metabolic processGO:0442678.4ACE, REN, INS

Molecular functions related to Hyporeninemic Hypoaldosteronism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3REN, INS

Products for genes affiliated with Hyporeninemic Hypoaldosteronism

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  • Antibodies
  • Proteins
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Sources for Hyporeninemic Hypoaldosteronism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet