MCID: HYP086
MIFTS: 69

Hypothyroidism malady

Genetic diseases, Endocrine diseases, Rare diseases, Immune diseases categories
Download this MalaCard

Summaries for Hypothyroidism

About this section
Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid dept. of health and human services office on women's health

MalaCards: Hypothyroidism, also known as thyroid diseases, is related to thyroiditis and congenital hypothyroidism. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Hormone ligand-binding receptors and Allograft rejection. The drug kelp preparation and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related mouse phenotypes are hearing/vestibular/ear and mortality/aging.

Disease Ontology:8 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia:65 Hypothyroidism (/?ha?p???a??r??d?z?m/), from hypo- (\"under\" in Greek) and thyroid (the thyroid gland),... more...

Aliases & Classifications for Hypothyroidism

About this section
Sources:
8Disease Ontology, 65Wikipedia, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Hypothyroidism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia family:

Congenital Hypothyroidism hypothyroidism
Familial Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duox2-Related Congenital Hypothyroidism, Iyd-Related
Congenital Hypothyroidism, Tpo-Related Hypothyroidism, Autoimmune
Transient Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 532)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5TPO, TG, SERPINA7, TSHR
2congenital hypothyroidism31.2TPO, TG, SERPINA7, POU1F1, PAX8, DUOX2
3hyperthyroidism31.0TPO, TG, SERPINA7, TSHR, TSHB
4autoimmune thyroiditis30.9TG, TPO
5myxedema30.9TSHR, TG, TPO
6goiter30.7SLC5A5, NKX2-1, TSHB, TSHR, TPO, TG
7thyrotoxicosis30.6TSHR, SERPINA7, TG, TPO
8graves' disease30.5TPO, TG, SERPINA7, PAX8, TSHR, FOXE1
9subacute thyroiditis30.5TSHR, TG, TPO
10endemic goiter30.3TPO, TG, TSHR
11adenoma30.2TPO, TG, POU1F1, PAX8, DUOX2, TSHR
12pendred syndrome30.2TPO, TG, PAX8, DUOX2
13panhypopituitarism30.2POU1F1, TSHB
14pregnancy loss30.1TG, TPO
15pituitary adenoma30.1TSHB, POU1F1, SERPINA7
16struma ovarii30.1NKX2-1, TSHR, TG
17addison's disease30.1TPO, TG
18thyroid agenesis30.1TG, SERPINA7, PAX8, TSHR, FOXE1, NKX2-1
19hyperthyroxinemia30.0TPO, SERPINA7, TSHR
20thyroid cancer30.0TPO, TG, PAX8, TSHR, NKX2-1, SLC5A5
21pernicious anemia30.0TPO, TG
22papillary carcinoma30.0NKX2-1, TSHR, PAX8, TG, TPO
23type 1 diabetes mellitus30.0TPO, TG, SERPINA7, TSHR
24multinodular goiter29.9TPO, TG, TSHR
25nodular goiter29.9TSHR, TG, TPO
26turner syndrome29.9SERPINA7, TG, TPO
27plummer's disease29.8TG, TPO
28toxic diffuse goiter29.7TSHR, TG, TPO
29papillary thyroid carcinoma29.7TPO, TG, PAX8, TSHR
30follicular adenoma29.7TPO, TG, PAX8, TSHR, NKX2-1
31thyroid adenoma29.6TPO, TG, SERPINA7, TSHR
32thyrotropin deficiency, isolated29.6TPO, TG, POU1F1, TSHB
33neonatal hypothyroidism10.9
34hepatitis10.5
35transient congenital hypothyroidism10.5
36congenital hypothyroidism, nongoitrous 110.4
37diabetes mellitus10.4
38myopathy10.4
39obesity10.4
40pericardial effusion10.4
41hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia10.4
42phenylketonuria10.3
43precocious puberty10.3
44hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.3
45cardiac tamponade10.3
46down syndrome10.3
47familial hypothyroidism10.3
48hyperprolactinemia10.3
49insulin resistance10.3
50hypopituitarism10.3

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to hypothyroidism

Symptoms for Hypothyroidism

About this section

Drugs & Therapeutics for Hypothyroidism

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hypothyroidism

About this section

Anatomical Context for Hypothyroidism

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hypothyroidism:

33
Thyroid, Testes, Heart, Pituitary, Brain, Bone, Kidney, Ovary, Testis, Endothelial, Liver, Breast, Skin, Cortex, Salivary gland, Lung, Eye, Spinal cord, Skeletal muscle, Colon, Smooth muscle, Fetal thyroid, Hypothalamus, Retina, T cells, Prostate, Uterus, Bone marrow, Pancreatic islet

Animal Models for Hypothyroidism or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Hypothyroidism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.1TPO, POU1F1, PAX8, DUOX2, TSHR
2MP:00107687.6POU1F1, PAX8, TSHR, FOXE1, NKX2-5, NKX2-1
3MP:00053797.2GLIS3, TPO, TG, POU1F1, PAX8, DUOX2
4MP:00053787.2TPO, TG, POU1F1, PAX8, DUOX2, TSHR
5MP:00036317.1TG, POU1F1, PAX8, DUOX2, TSHR, NKX2-5
6MP:00053766.9TPO, TG, POU1F1, PAX8, DUOX2, TSHR

Publications for Hypothyroidism

About this section
Sources:
52PubMed
See all sources

Articles related to Hypothyroidism:

(show top 50)    (show all 2048)
idTitleAuthorsYear
1
Effects of L-thyroxine therapy on circulating leptin and adiponectin levels in subclinical hypothyroidism: a prospective study. (23684667)
2013
2
Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)
2013
3
Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism. (23511952)
2013
4
Permanent and transient congenital hypothyroidism in Fayoum, Egypt: a descriptive retrospective study. (23840807)
2013
5
Congenital hypothyroidism after assisted reproductive technology in Japan: comparison between multiples and singletons, 2005-2009. (23402602)
2013
6
Developmental Hypothyroxinemia and Hypothyroidism Reduce Proliferation of Cerebellar Granule Neuron Precursors in Rat Offspring by Downregulation of the Sonic Hedgehog Signaling Pathway. (24264724)
2013
7
Craniofacial and dental manifestations of triple X syndrome associated with congenital hypothyroidism: a case report. (24117978)
2013
8
Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables. (24174944)
2013
9
Hypothyroidism after hemithyroidectomy. (23982782)
2013
10
Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring. (23777566)
2013
11
Preeclampsia, gestational hypertension and subsequent hypothyroidism. (23439671)
2013
12
Kocher-debre-semelaigne syndrome: hypothyroid muscular pseudohypertrophy-a rare report of two cases. (22934196)
2012
13
A new case of cerebro-facio-thoracic dysplasia in a 3-year-old girl with short stature and hypothyroidism. (22555342)
2012
14
Transient neonatal hypothyroidism in a boy with unbalanced translocation t(8;16). (23295299)
2012
15
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
16
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. (19438905)
2010
17
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (20153805)
2010
18
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis. (20094846)
2010
19
Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism. (20122987)
2010
20
Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. (19844123)
2009
21
Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. (17978827)
2008
22
Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. (17435671)
2007
23
Delta-aminolevulinate dehydratase (delta-ALA-D) activity in diabetes and hypothyroidism. (17291479)
2007
24
Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. (17880463)
2007
25
A study on dyslipidaemia in subclinical hypothyroidism. (17444061)
2006
26
Central hypothyroidism and hypophysitis during treatment of chronic hepatitis C with pegylated interferon alpha and ribavirin. (16702862)
2006
27
Hypothyroidism might be related to breast cancer in post-menopausal women. (16356089)
2005
28
Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. (16268812)
2005
29
Twenty years later: a reevaluation of the contribution of plasma thyroglobulin to the diagnosis of thyroid dysgenesis in infants with congenital hypothyroidism. (15329322)
2004
30
Hyperprolactinaemia in hypothyroidism: clinical significance and impact of TSH normalization. (12580934)
2003
31
Iodine sufficiency and measurements of thyroid function in maternal hypothyroidism. (12699443)
2003
32
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. (12165566)
2002
33
IGF-1 and IGFBP in congenital and acquired hypothyroidism after long-term replacement treatment. (10941423)
1999
34
In vivo and in vitro regulation of thyroid leukemia inhibitory factor (LIF): marker of hypothyroidism. (10443695)
1999
35
Serum creatine kinase levels in overt and subclinical hypothyroidism. (9848718)
1998
36
Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. (9185526)
1997
37
Hypothyroidism in a Brazilian kindred due to iodide trapping defect caused by a homozygous mutation in the sodium/iodide symporter gene. (9388506)
1997
38
Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. (8811668)
1996
39
Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. (8170469)
1994
40
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
41
Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)
1994
42
Sequence analysis of the thyrotropin (TSH) receptor gene in congenital primary hypothyroidism associated with TSH unresponsiveness. (7833660)
1994
43
Acquired von Willebrand's syndrome associated with decrease of plasminogen activator and its inhibitor during hypothyroidism. (8252160)
1993
44
Transient congenital hypothyroidism due to maternal thyrotrophin binding inhibiting immunoglobulin. (8104016)
1993
45
Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy. (2222095)
1990
46
The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism. (2106883)
1990
47
Neonatal hypothyroidism: recent developments. (3066322)
1988
48
Protease inhibitors in sera as possible indicators of familial hypothyroidism. (4044221)
1985
49
Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)
1974
50
Alteration by neonatal hypothyroidism of the critical period for the induction of persistent estrus in the rat. (5819715)
1969

Variations for Hypothyroidism

About this section

Expression for genes affiliated with Hypothyroidism

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for genes affiliated with Hypothyroidism

About this section
Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
See all sources

Pathways related to Hypothyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TSHB, TSHR
2
Show member pathways
9.4TPO, TG, TSHR, TSHB
3
Show member pathways
creatine-phosphate biosynthesis38
glycine degradation (creatine biosynthesis)38
putrescine biosynthesis III38
spermidine biosynthesis I38
tryptophan degradation via kynurenine38
spermine biosynthesis38
urea cycle38
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I38
tyrosine degradation I38
L-carnitine biosynthesis38
methylthiopropionate biosynthesis38
2-oxoglutarate decarboxylation to succinyl-CoA38
S-methyl-5-thioadenosine degradation II38
9.1SLC5A5, IYD, TSHB, TPO
49.1TPO, TG, TSHR, SLC5A5
5
Show member pathways
7.7SLC5A5, TPO, TG, PAX8, DUOX2, TSHR

Compounds for genes affiliated with Hypothyroidism

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2411.4TPO, TG
2diiodotyrosine4510.4TG, TPO
3gliadin4510.3TPO, TG
4carbimazole45 1111.2TSHR, TPO
5chromium4510.2TPO, TG
6amino acid4510.2TSHR, TPO
7kaempferol4510.1SLC5A5, TPO
8maltose45 1111.1TPO, TSHR
9propylthiouracil45 3 1112.0TSHR, TG, TPO
10cardiolipin45 1110.9TG, TPO
11liothyronine51 24 1111.9SERPINA7, TPO
12Hydrogen peroxide249.8DUOX2, TPO
13amiodarone45 51 29 1112.8SERPINA7, TG, TPO
14bisphenol a459.8SERPINA7, NRGN
15sodium dodecylsulfate459.7SERPINA7, TG, TPO
16asparagine459.6TSHR, SERPINA7, TPO
17agarose459.6TPO, SERPINA7, TSHR
18sialic acid459.6TG, SERPINA7, TSHR
19perchlorate459.5TPO, TG, DUOX2, SLC5A5
20methimazole45 3 1111.4TSHR, SERPINA7, TG, TPO
21chloramphenicol45 3 51 1112.3TSHB, TSHR, SERPINA7
22aspartate459.3TPO, TG, SERPINA7, TSHR
23triiodothyronine459.2TPO, TG, SERPINA7, TSHR, TSHB
24thymidine45 2410.1TSHB, TSHR, POU1F1, TG
2512-o-tetradecanoylphorbol 13-acetate459.1TPO, POU1F1, TSHR
26histidine459.0SERPINA7, TSHR, TPO
27125i458.9TPO, TG, SERPINA7, TSHR, SLC5A5
28glutamate458.8TPO, TG, POU1F1, TSHR, NRGN
29forskolin45 51 1110.8TPO, POU1F1, PAX8, TSHR, NKX2-1
30serine458.7TG, SERPINA7, PAX8, TSHR, NKX2-5, NKX2-1
31steroid458.6TPO, SERPINA7, POU1F1, NKX2-1
32acth458.6TPO, SERPINA7, POU1F1, TSHR, TSHB
33progesterone45 29 61 24 1112.6SERPINA7, POU1F1, TSHR, NKX2-1
34arginine458.6TPO, TG, SERPINA7, POU1F1, TSHR
35iodine45 249.5TPO, TG, SERPINA7, DUOX2, TSHR, SLC5A5
36alanine458.5TG, SERPINA7, POU1F1, TSHR, FOXE1
37thyroxine45 249.5TPO, TG, SERPINA7, PAX8, TSHR, TSHB
38sodium iodide458.5TPO, TG, PAX8, DUOX2, TSHR, NKX2-1
39retinoic acid45 249.4TPO, TG, POU1F1, TSHR, TSHB, NKX2-1
40estrogen458.3TG, SERPINA7, POU1F1, TSHR, TSHB, NKX2-1
41oligonucleotide458.3TPO, POU1F1, PAX8, TSHR, NKX2-1, SLC5A5
42sodium45 249.2TPO, TG, PAX8, DUOX2, TSHR, FOXE1
43tyrosine458.0TPO, TG, SERPINA7, POU1F1, TSHR, NKX2-1
44ribonucleic acid457.7TPO, TG, SERPINA7, POU1F1, PAX8, TSHR
45iodide45 248.2SLC5A5, TPO, TG, IYD, NKX2-1, FOXE1

GO Terms for genes affiliated with Hypothyroidism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hypothyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.7NKX2-1, NKX2-5, FOXE1

Biological processes related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1iodide transportGO:0157059.9SLC5A5, TG
2thyroid-stimulating hormone signaling pathwayGO:0381949.9PAX8, TSHR
3hormone biosynthetic processGO:0424469.8DUOX2, TG, TPO
4anatomical structure morphogenesisGO:0096539.6PAX8, TSHB, FOXE1
5cellular response to gonadotropin stimulusGO:0713719.5SLC5A5, PAX8
6response to vitamin AGO:0331899.5TSHB, SERPINA7
7hydrogen peroxide catabolic processGO:0427449.5TPO, DUOX2
8cellular nitrogen compound metabolic processGO:0346419.4SLC5A5, IYD, TPO
9thyroid gland developmentGO:0308788.8TG, PAX8, DUOX2, FOXE1, NKX2-5, NKX2-1
10negative regulation of transcription from RNA polymerase II promoterGO:0001228.7POU1F1, FOXE1, NKX2-5, NKX2-1, GLIS3
11thyroid hormone generationGO:0065908.7SLC5A5, IYD, FOXE1, DUOX2, TG, TPO
12positive regulation of transcription, DNA-templatedGO:0458938.6POU1F1, PAX8, FOXE1, NKX2-5, NKX2-1
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.6GLIS3, NKX2-1, NKX2-5, PAX8, POU1F1

Molecular functions related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1iodide peroxidase activityGO:00444710.1IYD, TPO
2thyroid-stimulating hormone receptor activityGO:0049969.8TSHR, PAX8
3peroxidase activityGO:0046019.7DUOX2, TPO
4RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.7FOXE1, NKX2-5, NKX2-1
5transcription regulatory region DNA bindingGO:0442129.6NKX2-1, NKX2-5, PAX8
6sequence-specific DNA bindingGO:0435658.6POU1F1, FOXE1, NKX2-5, NKX2-1
7sequence-specific DNA binding transcription factor activityGO:0037008.2POU1F1, PAX8, FOXE1, NKX2-5, NKX2-1, GLIS3

Products for genes affiliated with Hypothyroidism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypothyroidism

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet