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MCID: HYP086
MIFTS: 68

Hypothyroidism malady

Endocrine diseases category
1 drug, 285 genes, 29 tissues, 488 related diseases, clinical trials.

Summaries for Hypothyroidism

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid dept. of health and human services office on women's health

MalaCards: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and thyroiditis. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The drug kelp preparation and the compounds tyrosine and iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia:63 Hypothyroidism (/ˌhaɪpɵˈθaɪərɔɪdɪzəm/), from hypo- (\"under\" in Greek) and thyroid (the... more...

Aliases & Classifications for Hypothyroidism

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 63Wikipedia, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases
ICD10: 25


Aliases & Descriptions:

hypothyroidism 8 10 44 33 60
thyroid diseases 44 33 60
thyroid insufficiency 8
dysfunction thyroid 44
thyroid dysfunction 60
thyroid deficiency 8
thyroid disease 63


External Ids:

Disease Ontology8 DOID:1459
NCIt39 C26800
ICD9CM27 244.9
MeSH34 D007037
UMLS60 C002067

Related Diseases for Hypothyroidism

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia family:

Congenital Hypothyroidism hypothyroidism
Familial Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duox2-Related Congenital Hypothyroidism, Iyd-Related
Congenital Hypothyroidism, Tpo-Related Hypothyroidism, Autoimmune
Transient Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 488)
idRelated DiseaseScoreTop Affiliating Genes
1congenital hypothyroidism31.7TPO, TG, TSHR, TSHB, SERPINA7, GNAS
2thyroiditis31.5TSHR, SERPINA7, TRH, CTLA4, TG, TPO
3hyperthyroidism31.0GNAS, CTLA4, TRH, SERPINA7, TSHB, TSHR
4goiter30.9GNAS, NKX2-1, TRH, PAX8, SERPINA7, TSHB
5autoimmune thyroiditis30.8TG, TPO
6myxedema30.7TPO, TG, TSHR
7hepatitis30.6SERPINA7, CTLA4
8graves' disease30.6GNAS, TSHR
9thyrotoxicosis30.5TRH, SERPINA7, TG, TPO, TSHR
10diabetes mellitus30.5CTLA4
11adenoma30.4TRH, POU1F1, GNAS, CTLA4, TSHB, TSHR
12subacute thyroiditis30.4TSHR, TG, TPO
13celiac disease30.3CTLA4, TPO, TG
14thyroid cancer30.2SLC5A5, GNAS, NKX2-1, TG, PAX8, TRH
15pituitary adenoma30.2GNAS, TRH, POU1F1, SERPINA7, TSHB
16hypoparathyroidism30.2CTLA4
17infertility30.2PAX8, TPO
18dwarfism30.1POU1F1
19alopecia30.1BTD
20pendred syndrome30.1PAX8, TG, TPO, DUOX2
21endemic goiter30.1TPO, TSHR, TG
22diabetes insipidus30.1TRH
23papillary carcinoma30.0TPO, TSHR, NKX2-1, GNAS, PAX8, TG
24papillary thyroid carcinoma30.0TG, TPO, PAX8, TSHR
25candidiasis30.0BTD
26neonatal thyrotoxicosis30.0TSHR
27hyperthyroxinemia29.9TSHR, TPO, TRH, SERPINA7
28struma ovarii29.9NKX2-1, TG, TSHR
29addison's disease29.9TG, TPO, CTLA4
30deficiency anemia29.9TRH, GNAS, SERPINA7
31breast cancer29.9POU1F1, CTLA4
32multinodular goiter29.8TSHR, TG, TPO, GNAS
33nodular goiter29.8TSHR, TPO, TG, CTLA4
34toxic diffuse goiter29.8TG, TPO, TSHR
35turner syndrome29.8TPO, TG, SERPINA7
36acromegaly29.8TRH, GNAS
37pernicious anemia29.8TG, TPO
38thymoma29.8CTLA4, NKX2-1
39euthyroid sick syndrome29.8SERPINA7, TRH
40exophthalmos29.8TSHR, TRH
41follicular adenoma29.7GNAS, NKX2-1, PAX8, TSHR, TPO, TG
42thyroid agenesis29.6NKX2-1, FOXE1, TG, TSHR, SERPINA7, PAX8
43thyrotropin deficiency, isolated29.6POU1F1, TSHB, TPO, TG
44plummer's disease29.6TPO, TG
45endogenous depression29.6TRH
46cushing's syndrome29.6TRH
47kidney cancer29.6PAX8, NKX2-1, CTLA4, GNAS
48iodine hypothyroidism10.6
49congenital hypothyroidism, nongoitrous 110.3
50myopathy10.3

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to hypothyroidism

Clinical Features for Hypothyroidism

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Drugs & Therapeutics for Hypothyroidism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypothyroidism

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism

Search NIH Clinical Center for Hypothyroidism

Search CenterWatch for Hypothyroidism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypothyroidism

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Anatomical Context for Hypothyroidism

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32MalaCards
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MalaCards organs/tissues related to Hypothyroidism:

32
Thyroid, Testes, Heart, Pituitary, Brain, Bone, Kidney, Ovary, Testis, Cortex, Endothelial, Liver, Breast, Skin, Salivary gland, Skeletal muscle, Spinal cord, Lung, Eye, Colon, Hypothalamus, Prostate, Smooth muscle, Retina, T cells, Uterus, Bone marrow, Fetal thyroid, Pancreatic islet

Animal Models for Hypothyroidism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypothyroidism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
homeostasis/metabolism phenotype
MP:000537611.6TPO, GNAS, FOXE1, CTLA4, NKX2-5, NKX2-1
2
endocrine/exocrine gland phenotype
MP:000537911.5TG, TSHR, PAX8, GLIS3, POU1F1, TRH
3
nervous system phenotype
MP:000363111.3PAX8, POU1F1, TRH, DUOX2, NRGN, NKX2-1
4
growth/size phenotype
MP:000537811.2TG, DUOX2, TRH, POU1F1, GLIS3, BTD

Publications for Hypothyroidism

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Sources:
50PubMed
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Articles related to Hypothyroidism:

(show top 50)    (show all 2069)
idTitleAuthorsYear
1
Pure red cell aplasia as a presenting feature in systemic lupus erythematosus and association with thymoma, hypothyroidism and hypoparathyroidism: a case report and literature review. (24338260)
2014
2
Therapeutic exploration of betulinic acid in chemically induced hypothyroidism. (24096699)
2014
3
Do we treat hypothyroidism properly? A survey of 2488 patients from University Hospital Center, Zagreb, Croatia. (23337019)
2013
4
Hypothyroidism and Reversible Kidney Dysfunction: An Essential Relationship to Recognize. (24325990)
2013
5
Sleep apnea syndrome and hypothyroidism. (24114404)
2013
6
Recurrent hypokalemic paralysis: An atypical presentation of hypothyroidism. (23776877)
2013
7
Author reply to: serum ischaemic-modified albumin levels might not be a marker of oxidative stress in patients with hypothyroidism. (24272597)
2013
8
Changes of red blood cell rheology in newborns with congenital hypothyroidism during treatment. (23544882)
2013
9
Isolated central hypothyroidism in young siblings as a manifestation of PROP1 deficiency: clinical impact of whole exome sequencing. (23652424)
2013
10
Primary hypothyroidism masquerading as hepatocellular necrosis. (23345467)
2013
11
Subclinical hypothyroidism in children: natural history and when to treat. (23154159)
2013
12
Zinc deficiency associated with hypothyroidism: an overlooked cause of severe alopecia. (23960398)
2013
13
Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. (22271121)
2012
14
Prevalence of hypothyroidism among MDR-TB patients in Botswana. (23044454)
2012
15
High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role? (23326768)
2012
16
A review on post-puberty hypothyroidism: a glance at myxedema. (23350159)
2010
17
Genetics and phenomics of hypothyroidism due to TSH resistance. (20083154)
2010
18
Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. (18958631)
2009
19
Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. (17978827)
2008
20
Abnormal growth of the corticospinal axons into the lumbar spinal cord of the hyt/hyt mouse with congenital hypothyroidism. (18543337)
2008
21
Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism. (20477052)
2008
22
Birth prevalence of congenital hypothyroidism in Mexico. (18782254)
2008
23
Resetting the detection level of cord blood thyroid stimulating hormone (TSH) for the diagnosis of congenital hypothyroidism. (17878179)
2008
24
Biochemical severity of thyroid ectopia in congenital hypothyroidism demonstrates sexual dimorphism. (17218725)
2007
25
Initially elevated TSH and congenital central hypothyroidism due to a homozygous mutation of the TSH beta subunit gene: case report and review of the literature. (16804796)
2006
26
Congenital hypothyroidism alters the phosphorylation of ERK1/2 and p38MAPK in the hippocampus of neonatal rats. (15617763)
2005
27
Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. (15757851)
2005
28
Primary congenital hypothyroidism: defects in iodine pathways. (14514339)
2003
29
Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism. (11916616)
2002
30
Transient neonatal hypothyroidism after gestational exposure to amiodarone: a follow-up of two cases. (9854687)
1998
31
Genetic and linkage analysis of familial congenital hypothyroidism: exclusion of linkage to the TSH receptor gene. (9048917)
1997
32
Simultaneously found transient hypothyroidism due to Hashimoto's thyroiditis, autoimmune hepatitis and isolated ACTH deficiency after cessation of glucocorticoid administration. (9279524)
1997
33
Parathyroid carcinoma and primary autoimmune hypothyroidism in an elderly woman. (9125488)
1997
34
Congenital hypothyroidism caused by a premature termination signal in exon 10 of the human thyroid peroxidase gene. (8964831)
1996
35
Alpha fetoprotein in congenital hypothyroidism before and during treatment]. (7531094)
1994
36
Transient congenital hypothyroidism due to maternal thyrotrophin binding inhibiting immunoglobulin. (8104016)
1993
37
Hypothyroid-like regulation of the pituitary-thyroid axis in stable human immunodeficiency virus infection. (8492709)
1993
38
Cutis marmorata telangiectatica congenita: long-term follow-up, review of the literature, and report of a case in conjunction with congenital hypothyroidism. (8493172)
1993
39
Molecular pathology of congenital pituitary hypothyroidism--discovery of new clinical entities]. (8350517)
1993
40
Antithyroid antibodies. Prevalence in primary hypothyroidism in Central Tunisia]. (1819223)
1991
41
Circulating hormone concentrations in hypothyroid rats with induced polycystic ovaries. (1924408)
1991
42
Congenital hypothyroid dwarfism in a family of giant schnauzers. (2061865)
1991
43
Congenital hypothyroid dwarfism in a family of giant schnauzers. (1748985)
1991
44
The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism. (2106883)
1990
45
Topical iodine-containing antiseptics and neonatal hypothyroidism in very-low-birthweight infants. (2570908)
1989
46
Hypothyroidism as a cause of acquired von Willebrand's disease. (2883346)
1987
47
Selective effects of neonatal hypothyroidism on monoamine oxidase activities in the rat brain. (6834034)
1983
48
Hypothyroidism with true myotonia. (712368)
1978
49
Hypothyroidism in an area of endemic goiter and cretinism in Central Java, Indonesia. (65359)
1977
50
Conenital hypothyroidism in association with a ring chromosome 18. (5025476)
1972

Genetic Variations for Hypothyroidism

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Expression for genes affiliated with Hypothyroidism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for genes affiliated with Hypothyroidism

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Hypothyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Insulin secretion29
Hide members
11.1TSHR, GNAS, DUOX2, SLC5A5, PAX8, TSHB
2
Allograft rejection29
Hide members
10.8TG, TSHR, TPO, TSHB
3
Regulation of thyroid hormone activity53
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10.7SLC5A5, TPO, IYD
4
TSH signaling pathway37
10.7TSHB, PAX8, GNAS
5
Insulin secretion29
Hide members
10.7TG, TPO
6
Glycoprotein hormones53
Hide members
10.7TSHR, TSHB

Compounds for genes affiliated with Hypothyroidism

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.8GNAS, CTLA4, NKX2-1, NRGN, TRH, POU1F1
2iodide44 2412.8TG, TPO, IYD, TSHR, SERPINA7, PAX8
3ribonucleic acid4411.7GNAS, NKX2-1, POU1F1, PAX8, SERPINA7, TSHB
4iodine44 2412.7TRH, DUOX2, CTLA4, GNAS, SLC5A5, SERPINA7
5serine4411.6GNAS, CTLA4, NKX2-5, NKX2-1, BTD, PAX8
6thyroxine44 2412.6NRGN, TRH, PAX8, SERPINA7, TSHB, TSHR
7sodium44 2412.6FOXE1, NKX2-1, DUOX2, SLC5A5, PAX8, TSHR
8oligonucleotide4411.6GNAS, NKX2-1, TRH, POU1F1, SLC5A5, PAX8
9arginine4411.6GNAS, TRH, POU1F1, BTD, SERPINA7, TSHR
10glutamate4411.6GNAS, CTLA4, NRGN, TRH, POU1F1, TSHR
11alanine4411.6GNAS, FOXE1, CTLA4, POU1F1, BTD, SERPINA7
12estrogen4411.6CTLA4, NKX2-1, TRH, POU1F1, SERPINA7, TSHB
13sodium iodide4411.5TG, TPO, TSHR, PAX8, SLC5A5, DUOX2
14acth4411.5GNAS, TRH, POU1F1, SERPINA7, TSHB, TSHR
15forskolin44 49 1113.5GNAS, NKX2-1, TRH, POU1F1, PAX8, TSHR
16thymidine44 2412.5GNAS, CTLA4, TRH, POU1F1, TSHB, TSHR
17retinoic acid44 2412.4NKX2-1, NRGN, POU1F1, TSHB, TSHR, TPO
18triiodothyronine4411.4TRH, SERPINA7, TSHB, TSHR, TPO, TG
19progesterone44 59 28 11 2415.3GNAS, NKX2-1, TRH, POU1F1, SERPINA7, TSHR
20125i4411.3SLC5A5, SERPINA7, TSHR, TPO, TG
21methimazole44 2 1113.3TRH, SERPINA7, TSHR, TPO, TG
22steroid4411.3GNAS, CTLA4, NKX2-1, POU1F1, SERPINA7, TPO
23threonine4411.3GNAS, CTLA4, NKX2-1, PAX8, SERPINA7, TSHR
24perchlorate4411.2TG, TPO, SLC5A5, DUOX2
25calcium44 49 11 2414.2GNAS, CTLA4, NRGN, DUOX2, TRH, POU1F1
26cysteine4411.2GNAS, CTLA4, BTD, TSHR, TPO, TG
27asparagine4411.2GNAS, SERPINA7, TSHR, TPO
28adenylate4411.2GNAS, TRH, TSHR, TPO, TG
29glucose4411.2GNAS, CTLA4, TRH, BTD, SERPINA7, TSHR
30cyclic amp44 2412.2TSHR, POU1F1, TRH, NKX2-1, GNAS
31sialic acid4411.2GNAS, SERPINA7, TSHR, TG
32propylthiouracil44 2 1113.1TSHR, TPO, TG
33amiodarone44 49 28 1114.1SERPINA7, TPO, TG
34histidine4411.1GNAS, SERPINA7, TSHR, TPO
35polysaccharide4411.0TG, TPO, TSHR, GNAS
36octreotide44 59 28 1114.0GNAS, TRH, TG
37iodotyrosine44 2412.0TG, TPO
38diiodotyrosine4411.0TG, TPO
39acetylcholine44 49 28 11 2415.0TG, TPO, TRH, CTLA4
40carbimazole44 1111.9TPO, TSHR
41kaempferol4410.9TPO, SLC5A5
42sodium dodecylsulfate4410.9SERPINA7, TPO, TG
43hydrocortisone44 2 59 1113.7TG, TPO, TRH
44amino acid4410.7TPO, TSHR
45dexamethasone44 49 28 1113.6POU1F1, TRH, NRGN, NKX2-1, CTLA4
46Liothyronine11 2411.6SERPINA7, TPO

GO Terms for genes affiliated with Hypothyroidism

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16Gene Ontology
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Biological processes related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659011.3TG, TPO, IYD, SLC5A5, DUOX2, FOXE1
2thyroid gland developmentGO:03087811.2FOXE1, NKX2-5, NKX2-1, PAX8, TG
3positive regulation of transcription, DNA-dependentGO:04589311.1FOXE1, NKX2-5, NKX2-1, POU1F1, PAX8
4negative regulation of transcription from RNA polymerase II promoterGO:00012211.1FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3
5hormone biosynthetic processGO:04244611.0DUOX2, TPO, TG
6iodide transportGO:01570510.9TG, SLC5A5
7cellular response to gonadotropin stimulusGO:07137110.8PAX8, SLC5A5
8anatomical structure morphogenesisGO:00965310.7TSHB, PAX8, FOXE1
9response to vitamin AGO:03318910.7SERPINA7, TSHB
10hydrogen peroxide catabolic processGO:04274410.7TPO, DUOX2
11positive regulation of transcription from RNA polymerase II promoterGO:04594410.6PAX8, GLIS3, POU1F1, NKX2-1, NKX2-5
12response to corticosterone stimulusGO:05141210.5TRH, SERPINA7

Molecular functions related to Hypothyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.9FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3, PAX8
2iodide peroxidase activityGO:00444710.7TPO, IYD
3peroxidase activityGO:00460110.7TPO, DUOX2
4thyroid-stimulating hormone receptor activityGO:00499610.7TSHR, PAX8
5RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.4NKX2-1, NKX2-5, FOXE1

Products for genes affiliated with Hypothyroidism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypothyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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