MCID: HYP086
MIFTS: 60

Hypothyroidism

Categories: Endocrine diseases, Genetic diseases, Rare diseases, Immune diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 41 your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid to diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. they sometimes also use a biopsy. treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. dept. of health and human services office on women's health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, congenital, nongoitrous 4 and hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia. An important gene associated with Hypothyroidism is CHD7 (Chromodomain Helicase DNA Binding Protein 7), and among its related pathways/superpathways are Insulin secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Selenium and Leuprolide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 72 Hypothyroidism, also called underactive thyroid or low thyroid, is a common disorder of the endocrine... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia Congenital Hypothyroidism
Central Congenital Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duoxa2-Related Congenital Hypothyroidism, Duox2-Related
Congenital Hypothyroidism, Iyd-Related Congenital Hypothyroidism, Tpo-Related
Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs
Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 541)
id Related Disease Score Top Affiliating Genes
1 hypothyroidism, congenital, nongoitrous 4 33.7 TG TPO TSHB
2 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 33.0 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
3 chorea, hereditary benign 31.6 NKX2-1 PAX8 TG TPO TSHR
4 kidney disease 30.7 NKX2-1 TG TSHR
5 pseudohypoparathyroidism 30.4 TG TPO TSHR
6 lymphoma 30.1 TG TPO TSHR
7 adenohypophysitis 29.7 IYD SLC5A5 TG TPO
8 nephrogenic systemic fibrosis 29.6 PAX8 SLC5A5 TG TPO TSHR
9 endemic goiter 28.9 SERPINA7 SHBG TG TPO TSHR
10 congenital hypothyroidism 12.4
11 choreoathetosis, hypothyroidism, and neonatal respiratory distress 12.2
12 hypothyroidism, congenital, nongoitrous, 1 12.2
13 central congenital hypothyroidism 12.1
14 hypothyroidism, central, and testicular enlargement 12.1
15 diabetes mellitus, neonatal, with congenital hypothyroidism 12.1
16 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.0
17 hypothyroidism, congenital nongoitrous, 5 12.0
18 hypothyroidism, congenital, nongoitrous, 6 12.0
19 postsurgical hypothyroidism 12.0
20 neonatal hypothyroidism 11.8
21 hypothyroidism, congenital, nongoitrous, 3 11.8
22 idiopathic congenital hypothyroidism 11.8
23 muscular pseudohypertrophy-hypothyroidism syndrome 11.8
24 hypothyroidism due to deficient transcription factors involved in pituitary development or function 11.8
25 congenital hypothyroidism, duoxa2-related 11.7
26 congenital hypothyroidism, duox2-related 11.7
27 congenital hypothyroidism, iyd-related 11.7
28 congenital hypothyroidism, tpo-related 11.7
29 iodine hypothyroidism 11.7
30 hypothyroidism postaxial polydactyly mental retardation 11.6
31 obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome 11.6
32 ectodermal dysplasia, hypohidrotic, with hypothyroidism and agenesis of the corpus callosum 11.6
33 congenital hypothyroidism due to transplacental passage of maternal tsh-binding inhibitory antibodies 11.6
34 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 11.6
35 genetic transient congenital hypothyroidism 11.6
36 congenital hypothyroidism due to maternal intake of antithyroid drugs 11.6
37 hypothyroidism due to iodide transport defect 11.6
38 pendred syndrome 11.5
39 bamforth syndrome 11.5
40 myxedema 11.4
41 thyroid dyshormonogenesis 1 11.4
42 bamforth-lazarus syndrome 11.3
43 johanson-blizzard syndrome 11.3
44 thyroid dyshormonogenesis 3 11.3
45 thyroid dyshormonogenesis 2a 11.3
46 thyroid dyshormonogenesis 5 11.3
47 thyroid dyshormonogenesis 4 11.3
48 thyrotropin-releasing hormone deficiency 11.2
49 hashimoto thyroiditis 11.1
50 macroglossia 11.1

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 154)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Disorder Aplastic Anemia
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Paroxysmal Positional Nystagmus Bipolar Disorder
Borderline Personality Disorder Bronchiectasis
Bronchitis Bronchopneumonia
Cardiomyopathy, Familial Hypertrophic Celiac Disease
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conversion Disorder Cystitis
Decubitus Ulcer Deficiency Anemia
Delusional Disorder Dependent Personality Disorder
Dermatomycosis Diabetes Insipidus
Diabetic Polyneuropathy Dyshormonogenic Goiter
Dyskinesia of Esophagus Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Exophthalmos
Familial Atrial Fibrillation Female Breast Cancer
Female Stress Incontinence Femoral Vein Thrombophlebitis
First-Degree Atrioventricular Block Gastroesophageal Reflux

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 CHD7 GLIS3 IGSF1 NKX2-1 NKX2-5 PAX8
2 growth/size/body region MP:0005378 10.17 PAX8 TG THRA TPO TRH TRHR
3 homeostasis/metabolism MP:0005376 10 CHD7 DIO3 GLIS3 IGSF1 NKX2-1 NKX2-5
4 hearing/vestibular/ear MP:0005377 9.73 CHD7 PAX8 SLC26A4 THRA TPO TSHR
5 nervous system MP:0003631 9.65 CHD7 IGSF1 NKX2-1 NKX2-5 PAX8 SLC26A4
6 reproductive system MP:0005389 9.32 THRA TRHR TSHB TSHR CHD7 DIO3

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4,Phase 2 7782-49-2
2
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
3
Copper Approved Phase 4 7440-50-8 27099
4
Iron Approved Phase 4,Phase 2,Phase 1 7439-89-6 23925
5
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
6
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
7
Xylometazoline Approved Phase 4 526-36-3 5709
8
Bexarotene Approved, Investigational Phase 4 153559-49-0 82146
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
11
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
12
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
13
Iodine Investigational Phase 4,Phase 3,Phase 2 7553-56-2 807
14 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 insulin Phase 4
16 Insulin, Globin Zinc Phase 4
17 Antioxidants Phase 4,Phase 2
18 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
19 Protective Agents Phase 4,Phase 2
20 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
21 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
23 cadexomer iodine Phase 4,Phase 3,Phase 2
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2
25 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
26 Anti-Inflammatory Agents Phase 4
27 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Deslorelin Phase 4
30 Carboxymethylcellulose Sodium Phase 4
31 Cathartics Phase 4
32 Gastrointestinal Agents Phase 4
33 Laxatives Phase 4
34 Nicotinic Acids Phase 4
35 Vitamin B Complex Phase 4
36 Vitamins Phase 4,Phase 2
37 Antineoplastic Agents, Hormonal Phase 4
38 glucocorticoids Phase 4
39 Epoetin alfa Phase 4 113427-24-0
40 Hematinics Phase 4
41 Pharmaceutical Solutions Phase 4,Phase 2
42 Hypoglycemic Agents Phase 4
43
Proton pump inhibitors Phase 4
44 methionine Nutraceutical Phase 4
45 carnitine Nutraceutical Phase 4
46 Folate Nutraceutical Phase 4
47 Vitamin B3 Nutraceutical Phase 4
48 Vitamin B9 Nutraceutical Phase 4
49
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
50
Salmon Calcitonin Approved, Investigational Phase 3,Phase 2 47931-85-1 16129616

Interventional clinical trials:

(show top 50) (show all 199)

id Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Reverse the HYpoTHyroid Status in Acute Myocardial InfarCtion (RHYTHMIC) Unknown status NCT02512978 Phase 4 Levothyroxine
3 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
4 Post Partum Thyroiditis 2: Long Term Observations Unknown status NCT00287144 Phase 4
5 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
6 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
7 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
8 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
9 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
10 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
11 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
12 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
13 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
14 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
15 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
16 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
17 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
18 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
19 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
20 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
21 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
22 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4 No intervention
23 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
24 Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism Recruiting NCT02467244 Phase 4 Levothyroxine
25 Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Recruiting NCT02577367 Phase 4 Levothyroxine
26 Levothyroxine Replacement for Subclinical Hypothyroidism and Chronic Heart Failure Recruiting NCT03096613 Phase 4 Levothyroxine
27 The TRUST Study - Depression Substudy Recruiting NCT01853579 Phase 4 Levothyroxine;Placebo
28 Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors Recruiting NCT03094416 Phase 4 levothyroxine sodium capsule
29 Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Recruiting NCT02946918 Phase 4 Levothyroxine
30 Selenium Supplementation in Youths With Autoimmune Thyroiditis Recruiting NCT02644707 Phase 4
31 Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
32 Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism Active, not recruiting NCT01831869 Phase 4 L-thyroxine
33 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Active, not recruiting NCT02500342 Phase 4 Levothyroxine;Placebo
34 Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism Withdrawn NCT02186405 Phase 4 LEVOTHYROXINE
35 Levothyroxine in Pregnant SLE Patients Withdrawn NCT01276782 Phase 4 Levothyroxine
36 Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP Unknown status NCT01486667 Phase 3 levothyroxine;sugar pill
37 Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Unknown status NCT02548715 Phase 2, Phase 3 Levothyroxine;Placebo
38 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
39 Medico-Economic Comparison of Four Strategies of Radioiodine Ablation in Thyroid Carcinoma Patients Unknown status NCT00435851 Phase 3 Thyrogen, thyroid hormone withdrawal, iode 131
40 Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism Completed NCT02090907 Phase 2, Phase 3 Levothyroxine;Placebo
41 Subclinical Hypothyroidism and Mind in the Elderly Completed NCT00921050 Phase 2, Phase 3 levothyroxine sodium;excipient without levothyroxine (placebo)
42 Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy Completed NCT00388297 Phase 3 Levothyroxine;Placebo for Levothyroxine
43 Comparison of the Safety and Successful Ablation of Thyroid Remnant in Post-thyroidectomized Euthyroid Patients (i.e. Patients Administered Thyrogen) Versus Hypothyroid Patients (no Thyrogen) Following 131I Administration Completed NCT00196729 Phase 3 Thyrogen + Radioiodine (131I)
44 Generic vs. Name-Brand Levothyroxine Completed NCT00403390 Phase 3 Levothyroxine versus Levothyroxine
45 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
46 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
47 A New Study to Follow-up Thyroid Cancer Patients Who Participated in a Previous Study, Which Compared the Success of Destruction of the Thyroid Remnant Using Standard Treatment or Thyrogen. Completed NCT00295763 Phase 3 Thyrogen (thyrotropin alfa for injection)
48 Comparison Of Rituximab Versus Tositumomab and Iodine I 131 Tositumomab (BEXXAR® Therapeutic Regimen) For Patients With Relapsed Follicular Non-Hodgkins Lymphoma Completed NCT00268983 Phase 3
49 Efficacy of Nepeta Menthoides Extract on Anxiety of Patients With Depression: a Double-blind Randomized Controlled Clinical Trial Completed NCT02565316 Phase 2, Phase 3 Nepeta menthoides Boiss & Bohse freeze dried extract;Sertraline
50 rhTSH-Thyroid Ablation With 1850 MBq of 131I Completed NCT00454077 Phase 3

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

id Genetic test Affiliating Genes
1 Hypothyroidism 29

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

39
Thyroid, Testes, Heart, Pituitary, Bone, Brain, Kidney

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 2511)
id Title Authors Year
1
Intellectual development in preschool children with early treated congenital hypothyroidism. ( 28690988 )
2017
2
Hormonal and testicular changes in rats submitted to congenital hypothyroidism in early life. ( 27793676 )
2017
3
Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review. ( 28811156 )
2017
4
Evaluation of neurodevelopment of children with congenital hypothyroidism by the Denver Developmental Screening Test. ( 28917084 )
2017
5
Intelligence Quotient at the Age of 6 years of Iranian Children with Congenital Hypothyroidism. ( 28952455 )
2017
6
Homozygous DUOXA2 mutation (p.Tyr138(*)) in a girl with congenital hypothyroidism and her apparently unaffected brother: Case report and review of the literature. ( 28626131 )
2017
7
Occurrence of hyperprolactinemia in children with subclinical hypothyroidism. ( 28529200 )
2017
8
Pseudoacromegaly: an unusual presenting manifestation of long-standing undiagnosed primary hypothyroidism. ( 28500245 )
2017
9
Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? ( 28694389 )
2017
10
Prevalence of Congenital Hypothyroidism in Northern Border Region of Kingdom of Saudi Arabia. ( 28285292 )
2017
11
Hypopituitarism and hypothyroidism following atrioventricular block during nivolumab treatment. ( 28295551 )
2017
12
Hashimoto's Encephalitis: Rare Manifestation of Hypothyroidism. ( 28904921 )
2017
13
Randomized Trial Comparing Two Algorithms for Levothyroxine Dose Adjustment in Pregnant Women With Primary Hypothyroidism. ( 28911144 )
2017
14
A Frequent Oligogenic Involvement in Congenital Hypothyroidism. ( 28444304 )
2017
15
REGORAFENIB-INDUCED HYPOTHYROIDISM AND CANCER RELATED-FATIGUE: IS THERE A POTENTIAL LINK? ( 28468766 )
2017
16
Fighting against congenital hypothyroidism - Old soldiers never die. ( 28916230 )
2017
17
Hypothyroidism associated with nivolumab treatment of unresectable malignant melanoma. ( 28052364 )
2017
18
Primary Care Provider Management of Congenital Hypothyroidism Identified Through Newborn Screening. ( 28868522 )
2017
19
Radiation-induced hypothyroidism in patients with breast cancer: a retrospective analysis of 243 cases. ( 28502654 )
2017
20
No Association between 25 (OH) Vitamin D Level And Hypothyroidism among Females. ( 28507615 )
2017
21
Congenital Hypothyroidism: Facts, Facets & Therapy. ( 28176629 )
2017
22
Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program. ( 28809751 )
2017
23
Next-generation sequencing analysis of twelve known causative genes in congenital hypothyroidism. ( 28215547 )
2017
24
Unfavorable Course of Subclinical Hypothyroidism in Children with Hashimoto's Thyroiditis Compared to Those with Isolated Non-Autoimmune Hyperthyrotropinemia. ( 27914141 )
2017
25
A rare association of central hypothyroidism and adrenal insufficiency in a boy with Williams-Beuren syndrome. ( 28443262 )
2017
26
Cognitive profiles of patients with early detected and treated congenital hypothyroidism. ( 28097835 )
2017
27
Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study. ( 28532605 )
2017
28
Congenital hypothyroidism due to ectopic sublingual thyroid gland in Prader-Willi Syndrome: a case report. ( 28938886 )
2017
29
Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration. ( 28940199 )
2017
30
Mini-review: Discovery of GnIH and its role in hypothyroidism-induced delayed puberty. ( 28938445 )
2017
31
Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis. ( 28534147 )
2017
32
Provider variability in the initial diagnosis and treatment of congenital hypothyroidism. ( 28328531 )
2017
33
Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study. ( 28497360 )
2017
34
Prenatal diagnosis and successful intrauterine treatment of severe congenital hypothyroidism associated with fetal goiter. ( 27862717 )
2017
35
Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity. ( 28088629 )
2017
36
Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population. ( 28060725 )
2017
37
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism. ( 28225993 )
2017
38
Mutation analysis of the NKX2.5 gene in Iranian pediatric patients with congenital hypothyroidism. ( 28749785 )
2017
39
Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441). ( 28889340 )
2017
40
Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. ( 28562510 )
2017
41
Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10I1IU/mL have congenital hypothyroidism. ( 28738186 )
2017
42
Pilot Neonatal Screening Program for Central Congenital Hypothyroidism: Evidence of Significant Detection. ( 28898885 )
2017
43
Sub-Clinical Hypothyroidism and Its Association With Increased Cardiovascular Mortality: Call for Action. ( 28515819 )
2017
44
Primary Hypothyroid and Secondary Adrenal Insufficiency-Searching the Missing Link. ( 28571201 )
2017
45
[Characteristics of DUOXA2 gene mutation in children with congenital hypothyroidism]. ( 28100324 )
2017
46
Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. ( 28487744 )
2017
47
Soy isoflavones inducing overt hypothyroidism in a patient with chronic lymphocytic thyroiditis: a case report. ( 28870235 )
2017
48
Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism. ( 28633507 )
2017
49
MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis. ( 28007842 )
2017
50
Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. ( 28471544 )
2017

Variations for Hypothyroidism

ClinVar genetic disease variations for Hypothyroidism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic/Likely pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063
3 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038

Expression for Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for Hypothyroidism

GO Terms for Hypothyroidism

Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.99 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 THRA
2 positive regulation of multicellular organism growth GO:0040018 9.58 CHD7 DIO3 TSHR
3 hormone-mediated signaling pathway GO:0009755 9.56 THRA TRH TSHB TSHR
4 hormone biosynthetic process GO:0042446 9.5 DIO3 TG TPO
5 ventricular trabecula myocardium morphogenesis GO:0003222 9.49 CHD7 NKX2-5
6 adult heart development GO:0007512 9.48 CHD7 NKX2-5
7 cellular response to gonadotropin stimulus GO:0071371 9.46 PAX8 SLC5A5
8 thyroid hormone metabolic process GO:0042403 9.43 IYD TG
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.37 PAX8 TSHR
10 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
11 thyroid hormone generation GO:0006590 9.26 DIO3 IYD SLC5A5 TPO
12 thyroid gland development GO:0030878 9.02 NKX2-1 NKX2-5 PAX8 TG THRA

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.56 NKX2-1 NKX2-5 PAX8 THRA
2 hormone activity GO:0005179 9.5 TG TRH TSHB
3 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
4 iodide peroxidase activity GO:0004447 8.96 IYD TPO
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....