Hypothyroidism disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Hypothyroidism

Sources:
⁹Disease Ontology, ³³MedlinePlus, ⁶⁴Wikipedia, ³²MalaCards
See all sources

MedlinePlus:³³ Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid dept. of health and human services office on women's health

MalaCards based summary: Hypothyroidism, also known as thyroid diseases, is related to thyroiditis and autoimmune thyroiditis. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Hormone ligand-binding receptors and Allograft rejection. The drug kelp preparation and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related mouse phenotypes are hearing/vestibular/ear and mortality/aging.

Disease Ontology:⁹ A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia:⁶⁴ Hypothyroidism (/?ha?p???a??r??d?z?m/), from hypo- (\"under\" in Greek) and thyroid (the thyroid gland),... more...

Aliases & Classifications for Hypothyroidism

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ¹¹DISEASES, ⁴⁴Novoseek, ³³MedlinePlus, ⁶¹UMLS, ³⁴MeSH, ³⁹NCIt, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ²⁶ICD10
See all sources

Hypothyroidism, Aliases & Descriptions:

Name: Hypothyroidism ⁹ ¹¹ ⁴⁴ ³³ ⁶¹

Thyroid Diseases ⁴⁴ ³³ ⁶¹

Thyroid Insufficiency ⁹

Dysfunction Thyroid ⁴⁴

Thyroid Dysfunction ⁶¹

Thyroid Deficiency ⁹

Thyroid Disease ⁶⁴

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases, Immune diseases

ICD10: ²⁶

Endocrine, nutritional and metabolic diseases

Disorders of thyroid gland

Other disorders of thyroid

Other specified disorders of thyroid

Disorders of other endocrine glands

Disorders of endocrine glands in diseases classified elsewhere

Disorders of thyroid gland in diseases classified elsewhere

External Ids:

Disease Ontology⁹ DOID:1459

MeSH³⁴ D007037

NCIt³⁹ C26800

SNOMED-CT⁵⁶ 154660000, 237572004, 267465007 40930008, 190274003, 267377003, 190290003, more

ICD9CM²⁸ 244.9

ICD10²⁶ E00-E07, E07 E07.8, E35.0, more

UMLS⁶¹ C002067

Related Diseases for Hypothyroidism

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia family:

Congenital Hypothyroidism	hypothyroidism
Familial Hypothyroidism	Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duox2-Related	Congenital Hypothyroidism, Iyd-Related
Congenital Hypothyroidism, Tpo-Related	Hypothyroidism, Autoimmune
Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function	Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs
Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 546)

id	Related Disease	Score	Top Affiliating Genes
1	thyroiditis	31.6	TPO, TG, SERPINA7, TSHR
2	autoimmune thyroiditis	31.3	TG, TPO
3	myxedema	31.2	TSHR, TG, TPO
4	hyperthyroidism	30.9	TPO, TG, SERPINA7, TSHR, TSHB
5	subacute thyroiditis	30.8	TSHR, TG, TPO
6	endemic goiter	30.6	TPO, TG, TSHR
7	thyrotoxicosis	30.6	TSHR, SERPINA7, TG, TPO
8	pernicious anemia	30.4	TPO, TG
9	pregnancy loss	30.4	TG, TPO
10	struma ovarii	30.4	NKX2-1, TSHR, TG
11	addison's disease	30.3	TPO, TG
12	pendred syndrome	30.3	TPO, TG, PAX8, DUOX2
13	panhypopituitarism	30.3	POU1F1, TSHB
14	multinodular goiter	30.2	TPO, TG, TSHR
15	nodular goiter	30.2	TSHR, TG, TPO
16	plummer's disease	30.2	TG, TPO
17	hyperthyroxinemia	30.1	TPO, SERPINA7, TSHR
18	graves' disease	30.1	TPO, TG, SERPINA7, PAX8, TSHR, FOXE1
19	turner syndrome	30.1	SERPINA7, TG, TPO
20	goiter	30.1	SLC5A5, NKX2-1, TSHB, TSHR, TPO, TG
21	toxic diffuse goiter	30.0	TSHR, TG, TPO
22	papillary carcinoma	30.0	NKX2-1, TSHR, PAX8, TG, TPO
23	type 1 diabetes mellitus	29.9	TPO, TG, SERPINA7, TSHR
24	pituitary adenoma	29.9	TSHB, POU1F1, SERPINA7
25	papillary thyroid carcinoma	29.8	TPO, TG, PAX8, TSHR
26	thyroid agenesis	29.8	TG, SERPINA7, PAX8, TSHR, FOXE1, NKX2-1
27	congenital hypothyroidism	29.7	TPO, TG, SERPINA7, POU1F1, PAX8, DUOX2
28	follicular adenoma	29.7	TPO, TG, PAX8, TSHR, NKX2-1
29	thyroid adenoma	29.6	TPO, TG, SERPINA7, TSHR
30	thyrotropin deficiency, isolated	29.6	TPO, TG, POU1F1, TSHB
31	adenoma	29.5	TPO, TG, POU1F1, PAX8, DUOX2, TSHR
32	neonatal hypothyroidism	10.9
33	hepatitis	10.5
34	congenital hypothyroidism, nongoitrous 1	10.4
35	diabetes mellitus	10.4
36	obesity	10.4
37	myopathy	10.4
38	pericardial effusion	10.4
39	hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia	10.4
40	phenylketonuria	10.3
41	down syndrome	10.3
42	precocious puberty	10.3
43	cardiac tamponade	10.3
44	familial hypothyroidism	10.3
45	hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia	10.3
46	hyperprolactinemia	10.3
47	insulin resistance	10.3
48	hypogonadism	10.3
49	hypopituitarism	10.3
50	pseudohypoparathyroidism	10.3

Graphical network of the top 20 diseases related to Hypothyroidism:

Symptoms for Hypothyroidism

Drugs & Therapeutics for Hypothyroidism

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

kelp preparation

Genetic Tests for Hypothyroidism

Anatomical Context for Hypothyroidism

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Hypothyroidism:

³²

Thyroid, Testes, Heart, Pituitary, Brain, Bone, Kidney, Ovary, Testis, Liver, Endothelial, Cortex, Breast, Skin, Salivary gland, Eye, Spinal cord, Skeletal muscle, Colon, Lung, Bone marrow, Retina, Smooth muscle, Uterus, Prostate, T cells, Hypothalamus, Fetal thyroid, Pancreatic islet

Animal Models for Hypothyroidism or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Hypothyroidism:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	8.1	TPO, POU1F1, PAX8, DUOX2, TSHR
2	mortality/aging	MP:0010768	7.6	POU1F1, PAX8, TSHR, FOXE1, NKX2-5, NKX2-1
3	endocrine/exocrine gland phenotype	MP:0005379	7.2	GLIS3, TPO, TG, POU1F1, PAX8, DUOX2
4	growth/size/body phenotype	MP:0005378	7.2	TPO, TG, POU1F1, PAX8, DUOX2, TSHR
5	nervous system phenotype	MP:0003631	7.1	TG, POU1F1, PAX8, DUOX2, TSHR, NKX2-5
6	homeostasis/metabolism phenotype	MP:0005376	6.9	TPO, TG, POU1F1, PAX8, DUOX2, TSHR

Publications for Hypothyroidism

Sources:
⁵¹PubMed
See all sources

Articles related to Hypothyroidism:

(show top 50) (show all 2112)

id	Title	Authors	Year
1	Camurati-engelmann disease association with hypogonadism and primary hypothyroidism. (25389497)	Low S.F.... Ngiu C.S.	2014
2	Diagnosis, treatment and outcome of congenital hypothyroidism. (25231444)	Van Vliet G.... DeladoAy J.	2014
3	Incidence of congenital hypothyroidism in the Autonomous Province of Bolzano: benefit of increased iodine intake. (25403430)	Olivieri A.... Medda E.	2014
4	Effects of L-thyroxine therapy on circulating leptin and adiponectin levels in subclinical hypothyroidism: a prospective study. (23684667)	Yildiz B.O.... Bayraktar M.	2013
5	Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)	Ravanbod M.... Omrani G.R.	2013
6	Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism. (23511952)	D'Amico E.... Schurmans S.	2013
7	Permanent and transient congenital hypothyroidism in Fayoum, Egypt: a descriptive retrospective study. (23840807)	Bekhit O.E.... Yousef R.M.	2013
8	Congenital hypothyroidism after assisted reproductive technology in Japan: comparison between multiples and singletons, 2005-2009. (23402602)	Ooki S.	2013
9	Developmental Hypothyroxinemia and Hypothyroidism Reduce Proliferation of Cerebellar Granule Neuron Precursors in Rat Offspring by Downregulation of the Sonic Hedgehog Signaling Pathway. (24264724)	Wang Y.... Chen J.	2013
10	Craniofacial and dental manifestations of triple X syndrome associated with congenital hypothyroidism: a case report. (24117978)	Linhares Ferrazzo K.... Barbieri Mezomo M.	2013
11	Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables. (24174944)	Najmi S.B.... Ghasemi M.	2013
12	Hypothyroidism after hemithyroidectomy. (23982782)	Said M.... Haigh P.I.	2013
13	Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring. (23777566)	Albornoz E.A.... Riedel C.A.	2013
14	Preeclampsia, gestational hypertension and subsequent hypothyroidism. (23439671)	MAonnistAP T.... Suvanto E.	2013
15	Kocher-debre-semelaigne syndrome: hypothyroid muscular pseudohypertrophy-a rare report of two cases. (22934196)	Shaw C.... Shaw P.	2012
16	A new case of cerebro-facio-thoracic dysplasia in a 3-year-old girl with short stature and hypothyroidism. (22555342)	Smigiel R.... Sasiadek M.	2012
17	Transient neonatal hypothyroidism in a boy with unbalanced translocation t(8;16). (23295299)	Secchi L.A.... Neves F.d.e. .A.	2012
18	Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)	Bliddal S.... Feldt-Rasmussen U.	2011
19	Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. (19438905)	Machiavelli G.A.... Targovnik H.M.	2010
20	Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (20153805)	Spitzweg C.... Morris J.C.	2010
21	Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis. (20094846)	Kang I.N.... Junit S.M.	2010
22	Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. (19844123)	Thomas J.d.e. .V.... Collett-Solberg P.F.	2009
23	Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. (17978827)	Koh Y.W.... Kim S.C.	2008
24	Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. (17435671)	Dinleyici E.C.... Yarar C.	2007
25	Delta-aminolevulinate dehydratase (delta-ALA-D) activity in diabetes and hypothyroidism. (17291479)	Souza J.B.... Schetinger M.R.	2007
26	A study on dyslipidaemia in subclinical hypothyroidism. (17444061)	Bandyopadhyay S.K.... Murmu B.K.	2006
27	Central hypothyroidism and hypophysitis during treatment of chronic hepatitis C with pegylated interferon alpha and ribavirin. (16702862)	Ridruejo E.... Mando O.G.	2006
28	Hypothyroidism might be related to breast cancer in post-menopausal women. (16356089)	Kuijpens J.L.... Coebergh J.W.	2005
29	Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. (16268812)	Hueston W.J.... Geesey M.E.	2005
30	Twenty years later: a reevaluation of the contribution of plasma thyroglobulin to the diagnosis of thyroid dysgenesis in infants with congenital hypothyroidism. (15329322)	Djemli A.... Van Vliet G.	2004
31	Hyperprolactinaemia in hypothyroidism: clinical significance and impact of TSH normalization. (12580934)	Raber W.... Vierhapper H.	2003
32	Iodine sufficiency and measurements of thyroid function in maternal hypothyroidism. (12699443)	Mitchell M.L.... Faix J.D.	2003
33	A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. (12165566)	Castanet M.... Polak M.	2002
34	IGF-1 and IGFBP in congenital and acquired hypothyroidism after long-term replacement treatment. (10941423)	Bona G.... Chiorboli E.	1999
35	In vivo and in vitro regulation of thyroid leukemia inhibitory factor (LIF): marker of hypothyroidism. (10443695)	Ren S.G.... Melmed S.	1999
36	Serum creatine kinase levels in overt and subclinical hypothyroidism. (9848718)	Beyer I.W.... Fuss M.J.	1998
37	Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. (9185526)	Abramowicz M.J.... Heinrichs C.	1997
38	Hypothyroidism in a Brazilian kindred due to iodide trapping defect caused by a homozygous mutation in the sodium/iodide symporter gene. (9388506)	Pohlenz J.... Refetoff S.	1997
39	Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. (8811668)	Cleare A.J.... O'Keane V.	1996
40	Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. (8170469)	Stein S.A.... Jin S.	1994
41	Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)	Okuda J.... Mori T.	1994
42	Hyperprolactinemia in hypothyroidism: effects of L-thyroxine therapy]. (8035765)	Velardo A.... Marrama P.	1994
43	Sequence analysis of the thyrotropin (TSH) receptor gene in congenital primary hypothyroidism associated with TSH unresponsiveness. (7833660)	Takeshita A.... Yokoyama N.	1994
44	Acquired von Willebrand's syndrome associated with decrease of plasminogen activator and its inhibitor during hypothyroidism. (8252160)	Levesque H.... Courtois H.	1993
45	Transient congenital hypothyroidism due to maternal thyrotrophin binding inhibiting immunoglobulin. (8104016)	Schwingshandl J.... Silink M.	1993
46	Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy. (2222095)	Arem R.... Patsch W.	1990
47	The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism. (2106883)	Vranckx R.... Flink I.L.	1990
48	Protease inhibitors in sera as possible indicators of familial hypothyroidism. (4044221)	Smetana S.... Birk Y.	1985
49	Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)	Refetoff S.... Rosenfield R.L.	1974
50	Alteration by neonatal hypothyroidism of the critical period for the induction of persistent estrus in the rat. (5819715)	Kikuyama S.	1969

Genes related to Hypothyroidism

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Hypothyroidism:

(show all 16)

- Elite gene

id	Symbol	Description	Score	Implication
1	TPO	thyroid peroxidase	20.73	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
2	NKX2-1	NK2 homeobox 1	19.48	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
3	TG	thyroglobulin	18.22	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
4	TSHB	thyroid stimulating hormone, beta	16.97	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
5	NKX2-5	NK2 homeobox 5	15.72	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
6	FOXE1	forkhead box E1 (thyroid transcription factor 2)	14.46	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
7	GLIS3	GLIS family zinc finger 3	13.21	GeneCards inferred via : Disorders, Publications, Summaries (show sections)
8	NRGN	neurogranin (protein kinase C substrate, RC3)	11.95	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
9	IYD	iodotyrosine deiodinase	10.70	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
10	TSHR	thyroid stimulating hormone receptor	9.40	GeneCards inferred via : Publications, Disorders (show sections)
11	PAX8	paired box 8	8.15	GeneCards inferred via : Publications, Disorders (show sections)
12	DUOX2	dual oxidase 2	6.88	GeneCards inferred via : Publications, Disorders (show sections)
13	SLC5A5	solute carrier family 5 (sodium/iodide cotransporter), member 5	5.62	GeneCards inferred via : Publications, Disorders (show sections)
14	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	4.37	GeneCards inferred via : Publications, Disorders (show sections)
15	POU1F1	POU class 1 homeobox 1	3.12	GeneCards inferred via : Publications, Disorders (show sections)
16	IGSF1	immunoglobulin superfamily, member 1	1.86	GeneCards inferred via : Publications, Disorders (show sections)

Products for genes related to Hypothyroidism disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	14	-	16	16
2	Novus Biologicals	12	12	16	-

Variations for Hypothyroidism

Expression for genes affiliated with Hypothyroidism

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for genes affiliated with Hypothyroidism

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁰KEGG, ³⁷NCBI BioSystems Database, ⁵²QIAGEN
See all sources

Pathways related to Hypothyroidism according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Hormone ligand-binding receptors⁵⁴	9.8	TSHB, TSHR
2	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.4	TPO, TG, TSHR, TSHB
3	Metabolism of amino acids and derivatives⁵⁴ Show member pathways Methionine salvage pathway⁵⁴ Regulation of thyroid hormone activity⁵⁴ creatine-phosphate biosynthesis³⁷ glycine degradation (creatine biosynthesis)³⁷ putrescine biosynthesis III³⁷ Agmatine biosynthesis⁵⁴ spermidine biosynthesis I³⁷ Lysine catabolism⁵⁴ tryptophan degradation via kynurenine³⁷ Branched-chain amino acid catabolism⁵⁴ Metabolism of polyamines⁵⁴ spermine biosynthesis³⁷ urea cycle³⁷ Creatine metabolism⁵⁴ S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I³⁷ tyrosine degradation I³⁷ L-carnitine biosynthesis³⁷ Lysine biosynthesis³⁰ Amine-derived hormones⁵⁴ Phenylalanine and tyrosine catabolism⁵⁴ methylthiopropionate biosynthesis³⁷ 2-oxoglutarate decarboxylation to succinyl-CoA³⁷ Glyoxylate metabolism⁵⁴ S-methyl-5-thioadenosine degradation II³⁷ Urea cycle⁵⁴ Serine biosynthesis⁵⁴ Thyroxine biosynthesis⁵⁴ D-Arginine and D-ornithine metabolism³⁰ Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs⁵⁴ Amino acid synthesis and interconversion (transamination)⁵⁴ Interconversion of polyamines⁵⁴ Carnitine synthesis⁵⁴	9.1	SLC5A5, IYD, TSHB, TPO
4	Thyroxine (Thyroid Hormone) Production³⁷	9.1	TPO, TG, TSHR, SLC5A5
5	Insulin secretion³⁰ Show member pathways Ca2+ activated K+ channels⁵⁴ Thyroid hormone synthesis³⁰	7.7	SLC5A5, TPO, TG, PAX8, DUOX2, TSHR

Compounds for genes affiliated with Hypothyroidism

Sources:
⁴⁴Novoseek, ²⁵HMDB, ¹²DrugBank, ³BitterDB, ⁵⁰PharmGKB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	iodotyrosine⁴⁴ ²⁵	11.4	TPO, TG
2	diiodotyrosine⁴⁴	10.4	TG, TPO
3	gliadin⁴⁴	10.3	TPO, TG
4	carbimazole⁴⁴ ¹²	11.2	TSHR, TPO
5	chromium⁴⁴	10.2	TPO, TG
6	amino acid⁴⁴	10.2	TSHR, TPO
7	kaempferol⁴⁴	10.1	SLC5A5, TPO
8	maltose⁴⁴ ¹²	11.1	TPO, TSHR
9	propylthiouracil⁴⁴ ³ ¹²	12.0	TSHR, TG, TPO
10	cardiolipin⁴⁴ ¹²	10.9	TG, TPO
11	liothyronine⁵⁰ ²⁵ ¹²	11.9	SERPINA7, TPO
12	Hydrogen peroxide²⁵	9.8	DUOX2, TPO
13	amiodarone⁴⁴ ⁵⁰ ²⁹ ¹²	12.8	SERPINA7, TG, TPO
14	bisphenol a⁴⁴	9.8	SERPINA7, NRGN
15	sodium dodecylsulfate⁴⁴	9.7	SERPINA7, TG, TPO
16	asparagine⁴⁴	9.6	TSHR, SERPINA7, TPO
17	agarose⁴⁴	9.6	TPO, SERPINA7, TSHR
18	sialic acid⁴⁴	9.6	TG, SERPINA7, TSHR
19	perchlorate⁴⁴	9.5	TPO, TG, DUOX2, SLC5A5
20	methimazole⁴⁴ ³ ¹²	11.4	TSHR, SERPINA7, TG, TPO
21	chloramphenicol⁴⁴ ³ ⁵⁰ ¹²	12.3	TSHB, TSHR, SERPINA7
22	aspartate⁴⁴	9.3	TPO, TG, SERPINA7, TSHR
23	triiodothyronine⁴⁴	9.2	TPO, TG, SERPINA7, TSHR, TSHB
24	thymidine⁴⁴ ²⁵	10.1	TSHB, TSHR, POU1F1, TG
25	12-o-tetradecanoylphorbol 13-acetate⁴⁴	9.1	TPO, POU1F1, TSHR
26	histidine⁴⁴	9.0	SERPINA7, TSHR, TPO
27	125i⁴⁴	8.9	TPO, TG, SERPINA7, TSHR, SLC5A5
28	glutamate⁴⁴	8.8	TPO, TG, POU1F1, TSHR, NRGN
29	forskolin⁴⁴ ⁵⁰ ¹²	10.8	TPO, POU1F1, PAX8, TSHR, NKX2-1
30	serine⁴⁴	8.7	TG, SERPINA7, PAX8, TSHR, NKX2-5, NKX2-1
31	steroid⁴⁴	8.6	TPO, SERPINA7, POU1F1, NKX2-1
32	acth⁴⁴	8.6	TPO, SERPINA7, POU1F1, TSHR, TSHB
33	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	12.6	SERPINA7, POU1F1, TSHR, NKX2-1
34	arginine⁴⁴	8.6	TPO, TG, SERPINA7, POU1F1, TSHR
35	iodine⁴⁴ ²⁵	9.5	TPO, TG, SERPINA7, DUOX2, TSHR, SLC5A5
36	alanine⁴⁴	8.5	TG, SERPINA7, POU1F1, TSHR, FOXE1
37	thyroxine⁴⁴ ²⁵	9.5	TPO, TG, SERPINA7, PAX8, TSHR, TSHB
38	sodium iodide⁴⁴	8.5	TPO, TG, PAX8, DUOX2, TSHR, NKX2-1
39	retinoic acid⁴⁴ ²⁵	9.4	TPO, TG, POU1F1, TSHR, TSHB, NKX2-1
40	estrogen⁴⁴	8.3	TG, SERPINA7, POU1F1, TSHR, TSHB, NKX2-1
41	oligonucleotide⁴⁴	8.3	TPO, POU1F1, PAX8, TSHR, NKX2-1, SLC5A5
42	sodium⁴⁴ ²⁵	9.2	TPO, TG, PAX8, DUOX2, TSHR, FOXE1
43	tyrosine⁴⁴	8.0	TPO, TG, SERPINA7, POU1F1, TSHR, NKX2-1
44	ribonucleic acid⁴⁴	7.7	TPO, TG, SERPINA7, POU1F1, PAX8, TSHR
45	iodide⁴⁴ ²⁵	8.2	SLC5A5, TPO, TG, IYD, NKX2-1, FOXE1

GO Terms for genes affiliated with Hypothyroidism

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Hypothyroidism according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transcription factor complex	GO:005667	9.7	NKX2-1, NKX2-5, FOXE1

Biological processes related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	iodide transport	GO:015705	9.9	SLC5A5, TG
2	thyroid-stimulating hormone signaling pathway	GO:038194	9.9	PAX8, TSHR
3	hormone biosynthetic process	GO:042446	9.8	DUOX2, TG, TPO
4	anatomical structure morphogenesis	GO:009653	9.6	PAX8, TSHB, FOXE1
5	cellular response to gonadotropin stimulus	GO:071371	9.5	SLC5A5, PAX8
6	response to vitamin A	GO:033189	9.5	TSHB, SERPINA7
7	hydrogen peroxide catabolic process	GO:042744	9.5	TPO, DUOX2
8	cellular nitrogen compound metabolic process	GO:034641	9.4	SLC5A5, IYD, TPO
9	thyroid gland development	GO:030878	8.8	TG, PAX8, DUOX2, FOXE1, NKX2-5, NKX2-1
10	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.7	POU1F1, FOXE1, NKX2-5, NKX2-1, GLIS3
11	thyroid hormone generation	GO:006590	8.7	SLC5A5, IYD, FOXE1, DUOX2, TG, TPO
12	positive regulation of transcription, DNA-templated	GO:045893	8.6	POU1F1, PAX8, FOXE1, NKX2-5, NKX2-1
13	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	GLIS3, NKX2-1, NKX2-5, PAX8, POU1F1

Molecular functions related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	iodide peroxidase activity	GO:004447	10.1	IYD, TPO
2	thyroid-stimulating hormone receptor activity	GO:004996	9.8	TSHR, PAX8
3	peroxidase activity	GO:004601	9.7	DUOX2, TPO
4	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.7	FOXE1, NKX2-5, NKX2-1
5	transcription regulatory region DNA binding	GO:044212	9.6	NKX2-1, NKX2-5, PAX8
6	sequence-specific DNA binding	GO:043565	8.6	POU1F1, FOXE1, NKX2-5, NKX2-1
7	sequence-specific DNA binding transcription factor activity	GO:003700	8.2	POU1F1, PAX8, FOXE1, NKX2-5, NKX2-1, GLIS3