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MCID: HYP086
MIFTS: 59

Hypothyroidism malady

Endocrine category
1 drug, 285 genes, 482 related diseases, clinical trials.

Summaries for Hypothyroidism

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8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid dept. of health and human services office on women's health

MalaCards: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and thyroiditis. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The drug kelp preparation and the compounds tyrosine and iodide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia:64 Hypothyroidism (/ˌhaɪpɵˈθaɪərɔɪdɪzəm/), from hypo- (underactive) and thyroid (the thyroid... more...

Aliases & Classifications for Hypothyroidism

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 64Wikipedia, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine
ICD10: 25


Aliases & Descriptions:

hypothyroidism 8 10 45 34 61
thyroid diseases 45 34 61
thyroid insufficiency 8
dysfunction thyroid 45
thyroid dysfunction 61
thyroid deficiency 8
thyroid disease 64


External Ids:

Disease Ontology8 DOID:1459
NCIt40 C26800
ICD9CM27 244.9
MeSH35 D007037
UMLS61 C002067

Related Diseases for Hypothyroidism

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the congenital hypothyroidism family:

hypothyroidism familial hypothyroidism
hypothyroidism due to iodide transport defect hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia
hypothyroidism, autoimmune transient congenital hypothyroidism
hypothyroidism due to deficient transcription factors involved in pituitary development or function congenital hypothyroidism due to maternal intake of antithyroid drugs
congenital hypothyroidism due to transplacental passage of maternal tsh-binding inhibitory antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 482)
idRelated DiseaseScoreTop Affiliating Genes
1congenital hypothyroidism31.7TG, GNAS, FOXE1, NKX2-5, NKX2-1, TPO
2thyroiditis31.0TG, TPO, TSHR, SERPINA7, TRH, CTLA4
3myxedema30.8TSHR, TPO, TG
4autoimmune thyroiditis30.7TPO, TG
5graves' disease30.6TSHR, GNAS
6thyrotoxicosis30.5TRH, SERPINA7, TSHR, TPO, TG
7adenoma30.4GNAS, CTLA4, NKX2-1, DUOX2, TRH, POU1F1
8subacute thyroiditis30.4TSHR, TPO, TG
9acth deficiency30.3POU1F1
10celiac disease30.3TG, TPO, CTLA4
11thyroid cancer30.2NKX2-1, PAX8, TSHR, TPO, TG
12hypoparathyroidism30.2CTLA4
13thyroid agenesis30.2TG, TSHR, SERPINA7, PAX8, NKX2-1, FOXE1
14thyroid adenoma30.2TG, TPO, TSHR, SERPINA7, GNAS
15dwarfism30.2POU1F1
16alopecia30.2BTD
17growth hormone deficiency30.2POU1F1
18pendred syndrome30.1DUOX2, PAX8, TPO, TG
19endemic goiter30.1TSHR, TPO, TG
20mental retardation30.1TSHR, BTD, GNAS
21diabetes insipidus30.1TRH
22papillary carcinoma30.1GNAS, NKX2-1, PAX8, TSHR, TPO, TG
23thyrotropin deficiency, isolated30.1POU1F1, TSHB, TPO, TG
24neonatal thyrotoxicosis30.0TSHR
25hyperthyroxinemia30.0TRH, SERPINA7, TSHR, TPO
26struma ovarii30.0NKX2-1, TSHR, TG
27turner syndrome30.0SERPINA7, TPO, TG
28deficiency anemia30.0GNAS, TRH, SERPINA7
29gigantism29.9GNAS
30multinodular goiter29.8GNAS, TSHR, TPO, TG
31nodular goiter29.8CTLA4, TSHR, TPO, TG
32toxic diffuse goiter29.8TG, TPO, TSHR
33addison's disease29.8CTLA4, TPO, TG
34acromegaly29.8TRH, GNAS
35pernicious anemia29.8TPO, TG
36thymoma29.8NKX2-1, CTLA4
37infertility29.8TPO, PAX8
38euthyroid sick syndrome29.8TRH, SERPINA7
39exophthalmos29.8TSHR, TRH
40thyroid cancer, anaplastic29.6TG, TPO, TSHR, PAX8, NKX2-1
41pituitary tumors29.6TSHB, POU1F1, TRH, GNAS
42plummer's disease29.6TG, TPO
43cushing's syndrome29.6TRH
44neonatal hypothyroidism10.9
45hypothyroidism, autoimmune10.7
46iodine hypothyroidism10.6
47transient congenital hypothyroidism10.5
48familial hypothyroidism10.5
49n syndrome10.4
50hypohidrotic ectodermal dysplasia with hypothyroidism and ciliary dyskinesia10.3

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to hypothyroidism

Clinical Features for Hypothyroidism

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Drugs & Therapeutics for Hypothyroidism

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hypothyroidism

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism

Search NIH Clinical Center for Hypothyroidism

Search CenterWatch for Hypothyroidism

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hypothyroidism

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Anatomical Context for Hypothyroidism

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Animal Models for Hypothyroidism or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hypothyroidism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
homeostasis/metabolism phenotype
MP:000537611.6DUOX2, NKX2-1, NKX2-5, CTLA4, FOXE1, GNAS
2
endocrine/exocrine gland phenotype
MP:000537911.5TG, GNAS, FOXE1, CTLA4, NKX2-1, DUOX2
3
nervous system phenotype
MP:000363111.3NKX2-1, NRGN, DUOX2, TRH, POU1F1, PAX8
4
growth/size phenotype
MP:000537811.2GNAS, NKX2-5, NKX2-1, DUOX2, TRH, POU1F1

Publications for Hypothyroidism

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Sources:
51PubMed
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Articles related to Hypothyroidism:

(show top 50)    (show all 1949)
idTitleAuthorsYear
1
Paradox of rising thyroid stimulating hormone despite increasing thyroxine dose in hypothyroidism and the association with nephrotic syndrome. (23980816)
2013
2
Hypothyroidism and Risk of Mild Cognitive Impairment in Elderly Persons: A Population-Based Study. (24378475)
2013
3
A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers. (23956749)
2013
4
Primary hypothyroidism with growth failure and pituitary pseudotumor in a 13-year-old female: a case report. (23725039)
2013
5
Subclinical hypothyroidism in the first years of life in patients with Down syndrome. (23403803)
2013
6
Restoration of cardiac tissue thyroid hormone status in experimental hypothyroidism: a dose-response study in female rats. (23594789)
2013
7
Multicystic ovaries and pituitary pseudo-adenoma associated with primary hypothyroidism. (23259871)
2013
8
Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism. (24288742)
2013
9
Hypothyroidism after primary radiotherapy for head and neck squamous cell carcinoma: Normal tissue complication probability modeling with latent time correction. (23891099)
2013
10
Patient-reported outcomes in adequately treated hypothyroidism - insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ. (23618009)
2013
11
Consumptive hypothyroidism in an Egyptian baby with benign neonatal hemangiomatosis: a case report. (23418754)
2013
12
Dual ectopic thyroid in the presence of atrophic orthotopic thyroid gland in a patient with acquired hypothyroidism: Evaluation with hybrid Single-Photon Emission Computed Tomography/Computed Tomography. (24019671)
2013
13
Subclinical hypothyroidism and cardiovascular disease. (23090197)
2012
14
The autonomic condition of children with congenital hypothyroidism as indicated by the analysis of heart rate variability. (22112613)
2012
15
Functional characterization of four novel PAX8 mutations causing congenital hypothyroidism: new evidence for haploinsufficiency as a disease mechanism. (22898500)
2012
16
Choreoathetosis, congenital hypothyroidism and neonatal respiratory distress syndrome with intact NKX2-1. (23169673)
2012
17
Difficult treatment of consumptive hypothyroidism in a child with massive parotid hemangioma. (22570966)
2012
18
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
19
More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels. (21444648)
2011
20
Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw. (21624425)
2011
21
Pituitary hyperplasia secondary to primary hypothyroidism in children: report of 8 cases]. (20113627)
2010
22
Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas. (20435716)
2010
23
High prevalence of associated birth defects in congenital hypothyroidism. (20454578)
2010
24
Investigation of acquired von Willebrand Syndrome in children with hypothyroidism: reversal after treatment with thyroxine. (21175099)
2010
25
Congenital chylothorax and hypothyroidism: a case report and a review of the literature]. (19683420)
2009
26
Abnormal growth of the corticospinal axons into the lumbar spinal cord of the hyt/hyt mouse with congenital hypothyroidism. (18543337)
2008
27
Neuro-developmental deficits in early-treated congenital hypothyroidism. (19904446)
2008
28
Adult-onset Still's disease complicated by multiple cranial nerve palsy and hypothyroidism. (18419687)
2008
29
Cenani-Lenz syndactyly with facial dysmorphism, hypothyroidism, and renal hypoplasia: a case report. (18978656)
2008
30
Influence of L-thyroxine administration on poor-platelet plasma VEGF concentrations in patients with induced short-term hypothyroidism, monitored for thyroid carcinoma. (17090953)
2007
31
Titubation and paroxysmal dyskinesia: an unusual presentation of hypothyroidism. (17325092)
2007
32
Hypothyroidism is a predisposing factor for fenofibrate-induced rhabdomyolysis--patient report and literature review. (18447003)
2007
33
Effects of early high-dose levothyroxine treatment on auditory brain event-related potentials at school entry in children with congenital hypothyroidism. (16912511)
2006
34
Association of IgA nephropathy, hypothyroidism and hypercholesterolemia. (16358238)
2005
35
High prevalence of congenital hypothyroidism in the Greek Cypriot population: results of the neonatal screening program 1990-2000. (15921174)
2005
36
Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake. (15650362)
2004
37
Insulin resistance syndrome (syndrome X) and hypothyroidism. (11837779)
2001
38
Transient neonatal hypothyroidism alters plasma and testicular sex steroid concentration in puberal rats. (11019905)
2000
39
Transient neonatal hypothyroidism after gestational exposure to amiodarone: a follow-up of two cases. (9854687)
1998
40
Evidence for the segregation of three different mutated alleles of the thyroglobulin gene in a Brazilian family with congenital goiter and hypothyroidism. (9588493)
1998
41
Transient myeloproliferative disorder associated with Down syndrome and hypothyroidism. (7703050)
1995
42
Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of L-thyroxine therapy. (7949641)
1994
43
Acquired von Willebrand's syndrome associated with decrease of plasminogen activator and its inhibitor during hypothyroidism. (8252160)
1993
44
Antithyroid antibodies. Prevalence in primary hypothyroidism in Central Tunisia]. (1819223)
1991
45
The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism. (2106883)
1990
46
Influence of neonatal hypothyroidism on adrenal tyrosine hydroxylase activation in the young rat. (1972356)
1990
47
Transitory subclinical and permanent hypothyroidism in the course of subacute thyroiditis (de Quervain). (6428116)
1984
48
Transient secondary hypothyroidism and thyroxine binding globulin deficiency in leukemic children during polychemotherapy: an effect of L-asparaginase. (6167443)
1981
49
Pathology-epitomes of progress: screening for neonatal hypothyroidism. (18748596)
1980
50
Letter: Spontaneous primary hypothyroidism with unilateral exophthalmos. (4414403)
1974

Genetic Variations for Hypothyroidism

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Expression for genes affiliated with Hypothyroidism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for genes affiliated with Hypothyroidism

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Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Hypothyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Insulin secretion30
Hide members
11.1IYD, TSHR, TSHB, PAX8, SLC5A5, DUOX2
2
Allograft rejection30
Hide members
10.8TSHB, TSHR, TPO, TG
3
Regulation of thyroid hormone activity54
Hide members
10.7TPO, IYD, SLC5A5
4
TSH signaling pathway38
10.7TSHB, PAX8, GNAS
5
Insulin secretion30
Hide members
10.7TG, TPO
6
Glycoprotein hormones54
Hide members
10.7TSHB, TSHR

Compounds for genes affiliated with Hypothyroidism

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Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.8GNAS, CTLA4, NKX2-1, NRGN, TRH, POU1F1
2iodide45 2412.8TG, TPO, IYD, TSHR, SERPINA7, PAX8
3ribonucleic acid4511.7GNAS, NKX2-1, POU1F1, PAX8, SERPINA7, TSHB
4iodine45 2412.7TRH, DUOX2, CTLA4, GNAS, SLC5A5, SERPINA7
5serine4511.6GNAS, CTLA4, NKX2-5, NKX2-1, BTD, PAX8
6thyroxine45 2412.6NRGN, TRH, PAX8, SERPINA7, TSHB, TSHR
7sodium45 2412.6FOXE1, NKX2-1, DUOX2, SLC5A5, PAX8, TSHR
8oligonucleotide4511.6GNAS, NKX2-1, TRH, POU1F1, SLC5A5, PAX8
9arginine4511.6GNAS, TRH, POU1F1, BTD, SERPINA7, TSHR
10glutamate4511.6GNAS, CTLA4, NRGN, TRH, POU1F1, TSHR
11alanine4511.6GNAS, FOXE1, CTLA4, POU1F1, BTD, SERPINA7
12estrogen4511.6CTLA4, NKX2-1, TRH, POU1F1, SERPINA7, TSHB
13sodium iodide4511.5TG, TPO, TSHR, PAX8, SLC5A5, DUOX2
14acth4511.5GNAS, TRH, POU1F1, SERPINA7, TSHB, TSHR
15forskolin45 50 1113.5GNAS, NKX2-1, TRH, POU1F1, PAX8, TSHR
16thymidine45 2412.5GNAS, CTLA4, TRH, POU1F1, TSHB, TSHR
17retinoic acid45 2412.4NKX2-1, NRGN, POU1F1, TSHB, TSHR, TPO
18triiodothyronine4511.4TRH, SERPINA7, TSHB, TSHR, TPO, TG
19progesterone45 60 29 11 2415.3GNAS, NKX2-1, TRH, POU1F1, SERPINA7, TSHR
20125i4511.3SLC5A5, SERPINA7, TSHR, TPO, TG
21methimazole45 2 1113.3TRH, SERPINA7, TSHR, TPO, TG
22steroid4511.3GNAS, CTLA4, NKX2-1, POU1F1, SERPINA7, TPO
23threonine4511.3GNAS, CTLA4, NKX2-1, PAX8, SERPINA7, TSHR
24perchlorate4511.2TG, TPO, SLC5A5, DUOX2
25calcium45 50 11 2414.2GNAS, CTLA4, NRGN, DUOX2, TRH, POU1F1
26cysteine4511.2GNAS, CTLA4, BTD, TSHR, TPO, TG
27asparagine4511.2GNAS, SERPINA7, TSHR, TPO
28adenylate4511.2GNAS, TRH, TSHR, TPO, TG
29glucose4511.2GNAS, CTLA4, TRH, BTD, SERPINA7, TSHR
30cyclic amp45 2412.2TSHR, POU1F1, TRH, NKX2-1, GNAS
31sialic acid4511.2GNAS, SERPINA7, TSHR, TG
32propylthiouracil45 2 1113.1TSHR, TPO, TG
33amiodarone45 50 29 1114.1SERPINA7, TPO, TG
34histidine4511.1GNAS, SERPINA7, TSHR, TPO
35polysaccharide4511.0TG, TPO, TSHR, GNAS
36octreotide45 60 29 1114.0GNAS, TRH, TG
37iodotyrosine45 2412.0TG, TPO
38diiodotyrosine4511.0TG, TPO
39acetylcholine45 50 29 11 2415.0TG, TPO, TRH, CTLA4
40carbimazole45 1111.9TPO, TSHR
41kaempferol4510.9TPO, SLC5A5
42sodium dodecylsulfate4510.9SERPINA7, TPO, TG
43hydrocortisone45 2 60 1113.7TG, TPO, TRH
44amino acid4510.7TPO, TSHR
45dexamethasone45 50 29 1113.6POU1F1, TRH, NRGN, NKX2-1, CTLA4
46Liothyronine11 2411.6SERPINA7, TPO

GO Terms for genes affiliated with Hypothyroidism

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16Gene Ontology
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Biological processes related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659011.3TG, TPO, IYD, SLC5A5, DUOX2, FOXE1
2thyroid gland developmentGO:03087811.2FOXE1, NKX2-5, NKX2-1, PAX8, TG
3positive regulation of transcription, DNA-dependentGO:04589311.1FOXE1, NKX2-5, NKX2-1, POU1F1, PAX8
4negative regulation of transcription from RNA polymerase II promoterGO:00012211.1FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3
5hormone biosynthetic processGO:04244611.0DUOX2, TPO, TG
6iodide transportGO:01570510.9TG, SLC5A5
7cellular response to gonadotropin stimulusGO:07137110.8PAX8, SLC5A5
8anatomical structure morphogenesisGO:00965310.7TSHB, PAX8, FOXE1
9response to vitamin AGO:03318910.7SERPINA7, TSHB
10hydrogen peroxide catabolic processGO:04274410.7TPO, DUOX2
11positive regulation of transcription from RNA polymerase II promoterGO:04594410.6PAX8, GLIS3, POU1F1, NKX2-1, NKX2-5
12response to corticosterone stimulusGO:05141210.5TRH, SERPINA7

Molecular functions related to Hypothyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.9FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3, PAX8
2iodide peroxidase activityGO:00444710.7TPO, IYD
3peroxidase activityGO:00460110.7TPO, DUOX2
4thyroid-stimulating hormone receptor activityGO:00499610.7TSHR, PAX8
5RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.4NKX2-1, NKX2-5, FOXE1

Products for genes affiliated with Hypothyroidism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypothyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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