MCID: HYP086
MIFTS: 64

Hypothyroidism malady

Categories: Endocrine diseases, Genetic diseases, Rare diseases, Immune diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 41 your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid to diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. they sometimes also use a biopsy. treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. dept. of health and human services office on women's health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to choreoathetosis, hypothyroidism, and neonatal respiratory distress and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. The drugs Selenium and Bimatoprost have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 71 Hypothyroidism, also called underactive thyroid or low thyroid, is a common disorder of the endocrine... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia Congenital Hypothyroidism
Central Congenital Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duoxa2-Related Congenital Hypothyroidism, Duox2-Related
Congenital Hypothyroidism, Iyd-Related Congenital Hypothyroidism, Tpo-Related
Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs
Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 542)
id Related Disease Score Top Affiliating Genes
1 choreoathetosis, hypothyroidism, and neonatal respiratory distress 33.7 NKX2-1 PAX8 TG TPO TSHR
2 hypothyroidism, congenital, nongoitrous, 1 33.5 SERPINA7 TG TPO TRH TSHR
3 endemic goiter 29.5 SERPINA7 SHBG TG TPO TSHR
4 congenital hypothyroidism 12.4
5 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 12.2
6 hypothyroidism, central, and testicular enlargement 12.1
7 diabetes mellitus, neonatal, with congenital hypothyroidism 12.1
8 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.0
9 hypothyroidism, congenital nongoitrous, 5 12.0
10 hypothyroidism, congenital, nongoitrous, 6 12.0
11 postsurgical hypothyroidism 12.0
12 central congenital hypothyroidism 11.9
13 neonatal hypothyroidism 11.9
14 hypothyroidism, congenital, nongoitrous, 3 11.8
15 idiopathic congenital hypothyroidism 11.8
16 muscular pseudohypertrophy-hypothyroidism syndrome 11.8
17 hypothyroidism due to deficient transcription factors involved in pituitary development or function 11.8
18 iodine hypothyroidism 11.7
19 congenital hypothyroidism, duoxa2-related 11.7
20 congenital hypothyroidism, duox2-related 11.7
21 congenital hypothyroidism, iyd-related 11.7
22 congenital hypothyroidism, tpo-related 11.7
23 ectodermal dysplasia, hypohidrotic, with hypothyroidism and agenesis of the corpus callosum 11.6
24 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 11.6
25 genetic transient congenital hypothyroidism 11.6
26 congenital hypothyroidism due to maternal intake of antithyroid drugs 11.6
27 obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome 11.6
28 hypothyroidism due to iodide transport defect 11.6
29 hypothyroidism postaxial polydactyly mental retardation 11.6
30 congenital hypothyroidism due to transplacental passage of maternal tsh-binding inhibitory antibodies 11.6
31 pendred syndrome 11.6
32 myxedema 11.4
33 thyroid dyshormonogenesis 1 11.4
34 bamforth-lazarus syndrome 11.3
35 thyroid dyshormonogenesis 5 11.3
36 thyroid dyshormonogenesis 2a 11.3
37 thyroid dyshormonogenesis 4 11.3
38 thyroid dyshormonogenesis 3 11.3
39 johanson-blizzard syndrome 11.3
40 thyrotropin-releasing hormone deficiency 11.3
41 hypothryoidism, congenital, nongoitrous 4 11.3
42 hashimoto thyroiditis 11.1
43 macroglossia 11.1
44 hyperthyroidism 11.1
45 thryoid dyshormonogenesis 6 11.0
46 down syndrome 11.0
47 subacute thyroiditis 11.0
48 resistance to thyrotropin-releasing hormone syndrome 11.0
49 thyroid crisis 11.0
50 kocher-debre-semelaigne syndrome 11.0

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 154)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Adrenal Cortical Hypofunction Allergic Rhinitis
Alzheimer Disease Anxiety Disorder
Aplastic Anemia Atypical Depressive Disorder
Autonomic Nervous System Disease Basilar Artery Insufficiency
Benign Essential Hypertension Benign Paroxysmal Positional Nystagmus
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Cardiomyopathy, Familial Hypertrophic
Celiac Disease Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Communicating Hydrocephalus
Conjunctivitis Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.15 THRA TPO TRH TSHR DUOX2 IGSF1
2 growth/size/body region MP:0005378 10.1 IGSF1 NKX2-1 NKX2-5 PAX8 TG THRA
3 homeostasis/metabolism MP:0005376 9.97 DIO3 DUOX2 IGSF1 NKX2-1 NKX2-5 PAX8
4 hearing/vestibular/ear MP:0005377 9.73 DUOX2 PAX8 SLC26A4 THRA TPO TSHR
5 nervous system MP:0003631 9.7 DUOX2 IGSF1 NKX2-1 NKX2-5 PAX8 PRL
6 reproductive system MP:0005389 9.32 DIO3 DUOX2 IGSF1 NKX2-1 PAX8 PRL

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 715)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2 7782-49-2
2
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
3
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Travoprost Approved Phase 4 157283-68-6 5282226
6
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
7
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
11
Nitric Oxide Approved Phase 4 10102-43-9 145068
12
Nitroprusside Approved Phase 4 15078-28-1 11963622
13
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
15
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
16
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
17
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
18
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
21
Iron Approved Phase 4,Phase 2,Phase 1 7439-89-6 23925
22
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
23
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
24
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
25
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
26
Bexarotene Approved, Investigational Phase 4,Phase 3,Early Phase 1 153559-49-0 82146
27
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
28
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
29
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
30
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
31
Copper Approved Phase 4,Phase 2,Phase 3 15158-11-9, 7440-50-8 27099
32
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
33
Xylometazoline Approved Phase 4 526-36-3 5709
34
Diazepam Approved, Illicit, Vet_approved Phase 4,Phase 1 439-14-5 3016
35
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
36
Methyltestosterone Approved Phase 4,Phase 1,Early Phase 1 58-18-4 6010
37
Testosterone Approved, Investigational Phase 4,Phase 1,Early Phase 1 58-22-0 6013
38
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
39
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
40
Sertraline Approved Phase 4,Phase 2,Phase 3 79617-96-2 68617
41
Morphine Approved, Investigational Phase 4 57-27-2 5288826
42
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
43
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
45
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2180-92-9, 38396-39-3 2474
46
Clonidine Approved Phase 4,Phase 2 4205-90-7 2803
47
Tizanidine Approved Phase 4 51322-75-9 5487
48
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
49
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
50
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516

Interventional clinical trials:

(show top 50) (show all 1380)
id Name Status NCT ID Phase
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4
2 Thyroxine Titration Study Unknown status NCT00111735 Phase 4
3 Post Partum Thyroiditis 2: Long Term Observations Unknown status NCT00287144 Phase 4
4 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4
5 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
6 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4
7 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4
8 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4
9 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4
10 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4
11 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4
12 Comparison of the Vocal Cord Imaging Techniques After Thyroidectomy Unknown status NCT02410928 Phase 4
13 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4
14 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
15 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4
16 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy Unknown status NCT01779817 Phase 4
17 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4
18 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
19 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4
20 Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial Unknown status NCT02211053 Phase 4
21 Treatment of Subclinical Hyperthyroidism Unknown status NCT00213720 Phase 4
22 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4
23 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4
24 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4
25 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4
26 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4
27 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4
28 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4
29 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4
30 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4
31 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4
32 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
33 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4
34 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4
35 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
36 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4
37 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4
38 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4
39 A Retrospective Observational Study Comparing Two Different Treatment Options in Thyroid Cancer Patients With T4 Tumours Completed NCT01736163 Phase 4
40 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
41 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4
42 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Phase 4
43 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4
44 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4
45 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4
46 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4
47 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4
48 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4
49 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4
50 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

id Genetic test Affiliating Genes
1 Hypothyroidism 29

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

39
Thyroid, Testes, Heart, Pituitary, Brain, Bone, Kidney

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 2460)
id Title Authors Year
1
Prenatal diagnosis and successful intrauterine treatment of severe congenital hypothyroidism associated with fetal goiter. ( 27862717 )
2017
2
Three-year follow-up of children with abnormal newborn screening results for congenital hypothyroidism. ( 28412200 )
2017
3
Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study. ( 28058547 )
2017
4
Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. ( 28487744 )
2017
5
Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study. ( 28497360 )
2017
6
Congenital Hypothyroidism: Facts, Facets & Therapy. ( 28176629 )
2017
7
Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis. ( 28534147 )
2017
8
Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population. ( 28060725 )
2017
9
Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study. ( 28532605 )
2017
10
Hypothyroidism in Cancer Patients on Immune Checkpoint Inhibitors with anti-PD1 Agents: Insights on Underlying Mechanisms. ( 28073132 )
2017
11
REGORAFENIB-INDUCED HYPOTHYROIDISM AND CANCER RELATED-FATIGUE: IS THERE A POTENTIAL LINK? ( 28468766 )
2017
12
Pediatric Hypothyroidism: Diagnosis and Treatment. ( 28534114 )
2017
13
Cognitive profiles of patients with early detected and treated congenital hypothyroidism. ( 28097835 )
2017
14
Congenital Hypothyroidism: Role of Nuclear Medicine. ( 28237002 )
2017
15
Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients. ( 28473851 )
2017
16
MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis. ( 28007842 )
2017
17
Provider variability in the initial diagnosis and treatment of congenital hypothyroidism. ( 28328531 )
2017
18
Association between TPO Asn698Thr and Thr725Pro gene polymorphisms and serum anti-TPO levels in Iranian patients with subclinical hypothyroidism. ( 28500830 )
2017
19
Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity. ( 28088629 )
2017
20
Sex-comparative study of mouse cerebellum physiology under adult-onset hypothyroidism: The significance of GC-MS metabolomic data normalization in meta-analysis. ( 28040659 )
2017
21
Neurodevelopmental Outcome of Children with Congenital Hypothyroidism Diagnosed in a National Screening Program in Turkey. ( 28368265 )
2017
22
A rare association of central hypothyroidism and adrenal insufficiency in a boy with Williams-Beuren syndrome. ( 28443262 )
2017
23
Pseudoacromegaly: an unusual presenting manifestation of long-standing undiagnosed primary hypothyroidism. ( 28500245 )
2017
24
Occurrence of hyperprolactinemia in children with subclinical hypothyroidism. ( 28529200 )
2017
25
Congenital central hypothyroidism caused by a novel TSH-beta-subunit gene mutation (c.94G>A ) in two siblings. ( 28515030 )
2017
26
Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism. ( 28358714 )
2017
27
WAGR syndrome and congenital hypothyroidism in a child with a Mosaic 11p13 deletion. ( 28398607 )
2017
28
Sub-Clinical Hypothyroidism and Its Association With Increased Cardiovascular Mortality: Call for Action. ( 28515819 )
2017
29
Radiation-induced hypothyroidism in patients with breast cancer: a retrospective analysis of 243 cases. ( 28502654 )
2017
30
Risk factors for cardiovascular disease in subclinical hypothyroidism. ( 28493136 )
2017
31
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism. ( 28225993 )
2017
32
Erratum to: Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study. ( 28356101 )
2017
33
Hypothyroidism associated with nivolumab treatment of unresectable malignant melanoma. ( 28052364 )
2017
34
Prevalence of Congenital Hypothyroidism in Northern Border Region of Kingdom of Saudi Arabia. ( 28285292 )
2017
35
Unfavorable Course of Subclinical Hypothyroidism in Children with Hashimoto's Thyroiditis Compared to Those with Isolated Non-Autoimmune Hyperthyrotropinemia. ( 27914141 )
2017
36
Adding carbimazole to levothyroxine increases triiodothyronine and improves outcome in patients with primary hypothyroidism: a preliminary study from Egypt. ( 28465796 )
2017
37
Next-generation sequencing analysis of twelve known causative genes in congenital hypothyroidism. ( 28215547 )
2017
38
A Frequent Oligogenic Involvement in Congenital Hypothyroidism. ( 28444304 )
2017
39
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis. ( 28474257 )
2017
40
No Association between 25 (OH) Vitamin D Level And Hypothyroidism among Females. ( 28507615 )
2017
41
Next-generation sequencing of NKX2.1, FOXE1, PAX8, NKX2.5, and TSHR in 100 Chinese patients with congenital hypothyroidism and athyreosis. ( 28455095 )
2017
42
Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Familya8c. ( 28359061 )
2017
43
Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. ( 28471544 )
2017
44
Hormonal and testicular changes in rats submitted to congenital hypothyroidism in early life. ( 27793676 )
2017
45
Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children. ( 28049529 )
2017
46
Hypothyroidism with Slipped Capital Femoral Epiphysis. ( 27053178 )
2016
47
Effect of Hypothyroidism and Hyperthyroidism on Tissue Thyroid Hormone Concentrations in Rat. ( 27099836 )
2016
48
Unresolved Issues in the Wake of Newborn Screening forA CongenitalA Hypothyroidism. ( 27056453 )
2016
49
Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study. ( 27216400 )
2016
50
Reply to: Regarding the Article: Does Iodine Excess Lead to Hypothyroidism? Evidence from A Case-Control Study in India. ( 27181375 )
2016

Variations for Hypothyroidism

ClinVar genetic disease variations for Hypothyroidism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic/Likely pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063
3 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038

Expression for Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for Hypothyroidism

GO Terms for Hypothyroidism

Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.63 DUOX2 IYD TPO
2 hormone-mediated signaling pathway GO:0009755 9.62 THRA TRH TSHB TSHR
3 thyroid hormone metabolic process GO:0042403 9.54 DUOX2 IYD TG
4 hydrogen peroxide catabolic process GO:0042744 9.48 DUOX2 TPO
5 hormone biosynthetic process GO:0042446 9.46 DIO3 DUOX2 TG TPO
6 cellular response to gonadotropin stimulus GO:0071371 9.43 PAX8 SLC5A5
7 iodide transport GO:0015705 9.43 SLC26A4 SLC5A5 TG
8 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 PAX8 TSHR
9 thyroid hormone generation GO:0006590 9.35 DIO3 DUOX2 IYD SLC5A5 TPO
10 thyroid gland development GO:0030878 9.1 DUOX2 NKX2-1 NKX2-5 PAX8 TG THRA

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.62 NKX2-1 NKX2-5 PAX8 THRA
2 hormone activity GO:0005179 9.46 PRL TG TRH TSHB
3 iodide transmembrane transporter activity GO:0015111 9.26 SLC26A4 SLC5A5
4 iodide peroxidase activity GO:0004447 8.96 IYD TPO
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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