Hypothyroidism malady

MedlinePlus: Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. the thyroid helps set your metabolism - how your body gets energy from the foods you eat. millions of people in the u.s. have thyroid diseases. most of them are women. if you have a thyroid disease, your body uses energy more slowly or quickly than it should. a thyroid gland that is not active enough, called hypothyroidism, is far more common. it can make you gain weight, feel fatigued and have difficulty dealing with cold temperatures. if your thyroid is too active, it makes more thyroid hormones than your body needs. that condition is hyperthyroidism. too much thyroid hormone can make you lose weight, speed up your heart rate and make you very sensitive to heat. there are many causes for both conditions. treatment involves trying to reset your body's metabolism to a normal rate.²³

MalaCards: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and protein-energy malnutrition. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Selected targets of HNF1 and Adipocytokines & Insulin Signaling. The drug kelp and the compounds gnrh and iodine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are cardiovascular system and mortality/aging.

Disease Ontology: A thyroid gland disease which involves an underproduction of thyroid hormone.⁶

Wikipedia: Hypothyroidism /ˌhaɪpɵˈθaɪərɔɪdɪzəm/ is a state in which the thyroid gland does not make...⁴⁴ more...

Aliases & Descriptions:

hypothyroidism 6 7 8 32 43 thyroid diseases 17 32 23 43 thyroid insufficiency 6 dysfunction thyroid 32

thyroid dysfunction 43 thyroid deficiency 6 thyroid disease 44 malnutrition 43

Diseases related to hypothyroidism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1338)

id	Related Disease	Score	Top Affiliating Genes
1	congenital hypothyroidism	41.0	COG2, KIR2DS4, BTD, SERPINA7, VDR, LIPC
2	protein-energy malnutrition	33.8	RBP4, LEP, MPO, CD79A, GSR, GPT
3	goiter	33.5	RBP4, SELE, SERPINA7, VEGFA, LPO, BGLAP
4	autoimmune thyroiditis	33.5	SERPINA7, CHKB, IL2RA, IL4, CALCA, GHRL
5	neonatal hypothyroidism	32.9	PAX8, TPO, TSHR, TG, SLC5A5, ADCY10
6	hypothyroidism, autoimmune	32.7	IL2RA, IDDM12, AIRE, TPO, PTPRJ, CTLA4
7	pendred syndrome	30.7	PAX8, TPO, DUOX2, PTPRJ, DIO2, TG
8	type 1 diabetes mellitus	30.6	RETN, GCK, RBP4, SERPINA7, LPA, VDR
9	alcoholism	30.1	GSR, GPT, ALAD, GHRH, GHRL, TRH
10	hepatitis	29.9	RBP4, SELP, GSR, GPT, IFNA1, IFNA2
11	thyroid agenesis	29.9	SERPINA7, PAX8, FOXE1, TSHR, TG, NKX2-1
12	thyrotoxicosis	29.8	BGLAP, LEP, CGA, CD36, INS, IL2
13	pseudohypoparathyroidism	29.7	REN, BGLAP, CHKA, APC, IGF1, GNAS
14	hyperthyroxinemia	29.7	SERPINA7, CD79A, ALB, TRH, TPO, TTR
15	myxedema	29.5	CHKB, CD79A, TPO, CTLA4, TSHR, TG
16	celiac disease	29.3	IL6, IDDM12, HLA-DQB1, HLA-DRB1, TNF, CTLA4
17	cushing's syndrome	29.3	HSD11B2, GH1, SST, CRH, POMC
18	phenylketonuria	29.3	BTD, BGLAP, ALB, ALPP, GNRH1, GHRL
19	rickets	29.3	VDR, BGLAP, CD36, IGF1, ALB, ALPP
20	hyperthyroidism	29.1	PIK3C2A, COG2, REN, RETN, VWF, SELE
21	marasmus	28.7	IGFBP3, ALB, GH1, SHBG, LSL, TF
22	dwarfism	28.7	LHX3, INS, IGFBP3, IGF1, GH1, GHRH
23	hyperprolactinemia	28.6	SELE, SELP, VIP, BGLAP, CGA, CGB5
24	hypopituitarism	28.6	PBX1, LHX3, LHX4, LEP, CGA, INS
25	von willebrand's disease	28.5	VWF, SELP, F9, F8, F3, F2
26	hypoparathyroidism	28.4	PIK3C2A, VDR, BGLAP, INS, IL2RA, IGF1
27	thyroid cancer	28.4	PAX8, APC, CALCA, TPO, TSHR, TG
28	pituitary tumor	28.4	VIP, LIF, PBX1, CHGA, FSHR, APC
29	pseudohypoparathyroidism type ia	28.3	APC, IGF1, GNAS, GH1, TRH, PRL
30	nutritional deficiency disease	28.2	LEP, GHRL, TTR, TF
31	familial medullary thyroid carcinoma	28.2	CHGA, CALCA, SST, CRH, TG, POMC
32	endogenous depression	28.2	INS, GNRH1, TRH, TPO, CRH, TG
33	subacute thyroiditis	28.1	BGLAP, IL2RA, IL6, TPO, TNF, SHBG
34	thyroid hormone metabolism	28.1	INS, IL6, IGF1, TPO, DUOX2, DIO1
35	turner syndrome	28.0	SERPINA7, BGLAP, CGA, IGFBP3, IGF1, GH1
36	thyrotropin deficiency, isolated	28.0	PBX1, IGF1, GH1, TPO, TSHB, TG
37	delayed puberty	28.0	LEP, CGA, CGB5, FSHR, IGFBP3, IGF1
38	acanthosis nigricans	28.0	LEP, INS, IGF1, ALMS1, GH1, CYP21A2
39	respiratory failure	28.0	IL13, IGHE, PDE4D, G6PD, TTR, CXCL10
40	pericardial effusion	27.9	PIK3C2A, CHKB, CEACAM3, ALB, PSG2, ADA
41	hypocalcemia	27.9	PIK3C2A, VDR, BGLAP, CHKA, CHKB, CD36
42	adrenal hyperplasia	27.6	REN, BTD, SERPINA7, LEP, CGA, CGB5
43	sheehan syndrome	27.4	INS, IGF1, CRH, PRL, POMC, NEU1
44	hepatitis c	27.3	LIPC, LDLR, MTTP, GSR, IL10, IL2
45	neonatal diabetes mellitus	27.3	GCK, INS, IGF1, F2, GLIS3, TPO
46	galactosemia	27.2	BTD, BGLAP, CD36, INS, ACADM, G6PD
47	eating disorder	27.0	RETN, BGLAP, LEP, INS, IGFBP2, IGF1
48	anorexia nervosa	27.0	PIK3C2A, COG2, RETN, SERPINE1, LPA, LPL
49	parkinson's disease	27.0	CHKB, GSR, APOE, CASP3, GHRH, CYP2D6
50	glycogen storage disease type ia	26.9	VWF, BTD, LPL, CRP, SOD1, PON1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

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MalaCards organs/tissues related to hypothyroidism:

²²

MGI Mouse Phenotypes related to hypothyroidism:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	REN, VWF, RCAN2, RBP4, SELE, SELP
2	mortality/aging	MP:0010768	INF	PIK3C2A, LRPAP1, REN, CNP, VWF, GCK
3	growth/size phenotype	MP:0005378	INF	PIK3C2A, REN, CNP, RCAN2, GCK, BTD
4	renal/urinary system phenotype	MP:0005367	INF	LRPAP1, REN, GCK, BTD, SELP, RARA
5	muscle phenotype	MP:0005369	INF	REN, CNP, BTD, RBP4, VEGFA, LPL
6	hearing/vestibular/ear phenotype	MP:0005377	INF	VDR, RARA, PBX1, PAX8, ZEB1, LHX3
7	liver/biliary system phenotype	MP:0005370	INF	RETN, RCAN2, GCK, SERPINC1, VEGFA, LPL
8	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, RETN, RCAN2, SERPINE1, LPL, LIF
9	vision/eye phenotype	MP:0005391	INF	CNP, BTD, RBP4, SELE, SELP, SERPINC1
10	behavior/neurological phenotype	MP:0005386	INF	REN, CNP, RCAN2, BTD, SELE, SELP
11	hematopoietic system phenotype	MP:0005397	9.5	RCAN2, ZEB1, XBP1, FSHR, IL5, APC
12	respiratory system phenotype	MP:0005388	9.3	CNP, SELP, LPL, LIF, LHX4, UCP2
13	embryogenesis phenotype	MP:0005380	9.3	SERPINC1, PBX1, PAX8, XBP1, FOS, MED12
14	other phenotype	MP:0005395	8.8	LRPAP1, RARA, PBX1, LDLR, FSHR, IL13
15	normal phenotype	MP:0002873	6.7	LRPAP1, REN, RBP4, SELE, VIP, VEGFA
16	endocrine/exocrine gland phenotype	MP:0005379	INF	LRPAP1, CNP, PAX8, ZEB1, LHX3, LHX4
17	nervous system phenotype	MP:0003631	INF	LRPAP1, REN, CNP, VWF, SELP, SERPINC1
18	no phenotypic analysis	MP:0003012	INF	VEGFA, PAX8, LDLR, CD79A, INS, IL13
19	immune system phenotype	MP:0005387	INF	REN, CNP, VWF, RCAN2, SELP, VDR
20	cellular phenotype	MP:0005384	INF	VWF, RCAN2, RBP4, SELE, SELP, NAMPT
21	tumorigenesis	MP:0002006	INF	SERPINE1, RARA, ZEB1, LEP, B2M, FSHR
22	digestive/alimentary phenotype	MP:0005381	INF	CNP, VWF, VEGFA, VDR, RARA, LIF
23	skeleton phenotype	MP:0005390	INF	CNP, RCAN2, VEGFA, VDR, RARA, LIF
24	limbs/digits/tail phenotype	MP:0005371	INF	RCAN2, VEGFA, VDR, RARA, PBX1, ZEB1
25	reproductive system phenotype	MP:0005389	INF	LRPAP1, REN, CNP, RBP4, VIP, VEGFA
26	craniofacial phenotype	MP:0005382	INF	PBX1, PAX8, ZEB1, LHX3, FOXE1, MED12
27	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, LRPAP1, REN, RETN, CNP, VWF
28	integument phenotype	MP:0010771	INF	BTD, SELP, LIF, PBX1, ZEB1, LDLR

Articles related to hypothyroidism:

(show top 50)    (show all 566)

id	Title	Authors	Year	Affiliating Genes
1	Serum vaspin levels in hypothyroid patients. (21798959)	Cinar N.... GA1rlek A.	2011	SERPINA12
2	Mutations in the gene encoding paired box domain (PAX 8) are not a frequent cause of congenital hypothyroidism (CH) in Iranian patien ts with thyroid dysgenesis. (20857061)	Mahjoubi F.... Hashemipour M.	2010	PAX8
3	Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent devel opment of thyroid carcinoma. (20089614)	Raef H.... Shi Y.	2010	TG
4	Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. (19548001)	Bessho K.... Ozono K.	2010	DIO3
5	Compound heterozygosity for a novel hemizygous missen se mutation and a partial deletion affecting the catalytic core of the H2O2-gen erating enzyme DUOX2 associated with transient congenital hypothyroidism. (20187165)	Hoste C.... De Deken X.	2010	TPO, DUOX2
6	Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. (19820008)	Shields B.M.... Vaidya B.	2009	PDE8B
7	Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia. (18727713)	De Marco G.... Tonacchera M.	2009	TSHR
8	Identification and characterization of four PAX8 rare sequence variants (p.T225M, p.L233L, p.G336S and p.A439A) in patients with congenital hypothyroidism and dysgenetic thyroid glands. (17980011)	Esperante S.A.... Targovnik H.M.	2008	PAX8, ZEB1
9	Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. (18936354)	De Carlucci D.... Cernea C.R.	2008	TPO
10	Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones concentrations. (18283268)	Owecki M.... Sowinski J.	2008	RETN
11	Incomplete isosexual puberty, myopathy, and pseudoprolactinoma in a 20-year-old girl with primary hypothyroidism (17897903)	SidibAc e.l. .H.	2007	PRL
12	Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. (17202116)	Rini B.I.... Bukowski R.M.	2007	VEGFA
13	Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. (17468187)	Al Taji E.... Krude H.	2007	PAX8, NKX2-1
14	Which thyroid-stimulating hormone level should be sought in hypothyroid patients under L-thyroxine replacement therapy? (16805747)	Gursoy A.... Gullu S.	2006	CRP
15	Effect of thyroxine replacement on serum IGF-I, IGFBP-3 and the acid-labile subunit in patients with hypothyroidism and hypopituitarism. (17121519)	Schmid C.... Wiesli P.	2006	IGF1, IGFBP3
16	Congenital hypothyroidism (17072233)	Carranza D.... Polak M.	2006	FOXE1
17	Somatostatin treatment of congenital chylothorax may induce transient hypothyroidism in newborns. (16188789)	Maayan-Metzger A.... Kuint J.	2005	SST
18	Serum creatine kinase levels in overt and subclinical hypothyroidism. (16392619)	Hekimsoy Z.... Oktem I.K.	2005	CHKB
19	Subclinical hypothyroidism: a comparison of strategies to achieve adherence to treatment guidelines. (15117432)	Lock R.J.... Gompels M.M.	2004	TPO
20	Late-onset primary hyperoxaluria triggered by hypothyroidism and presenting as rapidly progressive renal failure--description of a new mutation. (15356974)	Tintillier M.... Donckier J.	2004	AGXT
21	Congenital hypothyroidism and apparent athyreosis with compound heterozygosity or compensated hypothyroidism with probable hemizygosity for inactivating mutations of the TSH receptor. (14725684)	Park S.-M.... Chatterjee V.K.K.	2004	TSHR
22	Lipids profile in a group of hypothyroid patients vs. treated hypothyroid patients (15832973)	GA8leA9anu C.... Zbranca E.	2004	LPL
23	Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. (15320969)	Tonacchera M.... Pinchera A.	2004	FOXE1, TTF2
24	Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism. (15171721)	Baryshev M.... Mkrtchian S.	2004	CALR, P4HB, XBP1
25	Effect of hypothyroidism and its treatment on the IGF system in infants and children. (12585338)	Purandare A.... Wilson T.A.	2003	IGF1, IGFBP3, IGFBP2
26	Iodine sufficiency and measurements of thyroid function in maternal hypothyroidism. (12699443)	Mitchell M.L.... Faix J.D.	2003	TG
27	Congenital isolated central hypothyroidism caused by a 'hot spot' mutation in the thyrotropin-beta gene. (12593729)	McDermott M.T.... Ridgway E.C.	2002	TSHB
28	Prevalence of hypergastrinemia in patients with hyper- and hypothyroidism: impact for calcitonin? (12006703)	Vierhapper H.... Gessl A.	2002	GAST
29	Human mitochondrial transcription factor A reduction and mitochondrial dysfunction in Hashimoto's hypothyroid myopathy. (12428064)	Siciliano G.... Murri L.	2002	TFAM
30	Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism. (12050212)	Alberti L.... Persani L.	2002	TSHR
31	Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism. (11424983)	Philibert R.A.... Wassink T.H.	2001	MED12
32	A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus. (11847467)	Blankenstein O.... Heimann G.	2001	POU1F1
33	A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child. (11502839)	Congdon T.... Kopp P.	2001	PAX8, FOXE1
34	Development of primary hypothyroidism with the appearance of blocking-type antibody to thyrotropin receptor in Graves' disease in late pregnancy. (10090319)	Ueta Y.... Shigemasa C.	1999	TSHR
35	Thyroxine inversely regulates serum intermediate dens ity lipoprotein levels in children with congenital hypothyroidism. (10365575)	Asami T.... Uchiyama M.	1999	LIPC
36	Myopathy as the persistently isolated symptomatology of primary autoimmune hypothyroidism. (9848719)	Rodolico C.... Vita G.	1998	DES
37	Neonatal transient hypothyroidism: aetiological study. Italian Collaborative Study on Transient Hypothyroidism. (9797631)	Weber G.... Chiumello G.	1998	TPO
38	Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism. (9435431)	Tan K.C.... Kung A.W.	1998	CETP
39	Hypothyroidism due to thyrotropin-receptor blocking antibodies associated with sarcoidosis. (9137702)	Heshmati H.M.... Orgiazzi J.	1997	TSHR
40	Transient secondary hypothyroidism in children after cardiac surgery. (9078538)	Bettendorf M.... SchAPnberg D.K.	1997	TG
41	Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. (8811668)	Cleare A.J.... O'Keane V.	1996	PRL
42	Thyrotropin receptor antibodies in hypothyroid Graves' disease. (8094394)	Kasagi K.... Konishi J.	1993	TPO, TG
43	The use of immunoregulator preparations in the combined treatment of idiopathic hypothyroidism (8296231)	Epishin A.V.... Venger E.P.	1993	TMPO
44	Monoamine regulation of prolactin and TSH secretion in hypothyroidism. (1519463)	Gerasimov G.... Goncharov N.	1992	PRL, TRH
45	Primary hypothyroidism in normal thyroid gland morphology (1348235)	Heik S.C.... Greten H.	1992	TSHR, TG
46	Treatment of hypothyroidism reduces low-density lipoproteins but not lipoprotein(a). (1386404)	Klausen I.C.... Faergeman O.	1992	LDLR
47	Covert hypothyroidism presenting as a cardiovascular event. (1951418)	LeMar H.J.... Hofeldt F.D.	1991	PIK3C2A
48	Antithyroid antibodies. Prevalence in primary hypothyroidism in Central Tunisia (1819223)	Chaieb L.... Bchir F.	1991	TG
49	Circulating hormone concentrations in hypothyroid rats with induced polycystic ovaries. (1924408)	Lee M.T.... Bruot B.C.	1991	PRL, CGB5
50	Hypothyroid myopathy. Clinico-pathologic study of 20 cases (2103763)	del Palacio A.... Ricoy J.R.	1990	PIK3C2A

Genes related to hypothyroidism according to GeneCards:

(show top 50)    (show all 204)

id	Symbol	Description	Score	GeneCards Section Context
1	TPO	thyroid peroxidase	11.1	Publications, Summaries
2	NKX2-1	NK2 homeobox 1	11.1	Summaries, Publications
3	TG	thyroglobulin	11.1	Summaries, Publications
4	TSHB	thyroid stimulating hormone, beta	11.1	Summaries, Publications
5	NKX2-5	NK2 homeobox 5	11.1	Summaries
6	GLIS3	GLIS family zinc finger 3	11.1	Summaries, Publications
7	CHNG3	Hypothyroidism, congenital, nongoitrous, 3	11.0	Aliases & Descriptions
8	FOXE1	forkhead box E1 (thyroid transcription factor 2)	11.0	Publications, Summaries
9	NRGN	neurogranin (protein kinase C substrate, RC3)	11.0	Publications, Summaries
10	TRH	thyrotropin-releasing hormone	11.0	Publications, Summaries
11	IYD	iodotyrosine deiodinase	11.0	Publications, Summaries
12	PAX8	paired box 8	11.0	Publications
13	TSHR	thyroid stimulating hormone receptor	11.0	Publications
14	SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	11.0	Publications
15	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
16	DUOX2	dual oxidase 2	11.0	Publications
17	POU1F1	POU class 1 homeobox 1	11.0	Publications
18	BTD	biotinidase	11.0	Publications
19	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
20	GNAS	GNAS complex locus	11.0	Publications
21	IDDM12	insulin-dependent diabetes mellitus 12	11.0
22	DUOX1	dual oxidase 1	11.0	Publications
23	AIRE	autoimmune regulator	11.0	Publications
24	SLC26A4	solute carrier family 26, member 4	11.0	Publications
25	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
26	COG2	component of oligomeric golgi complex 2	11.0	Publications
27	CHKB	choline kinase beta	11.0	Publications
28	GHRH	growth hormone releasing hormone	11.0	Publications
29	CHKA	choline kinase alpha	11.0	Publications
30	SHBG	sex hormone-binding globulin	11.0	Publications
31	ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	11.0
32	PRL	prolactin	11.0	Publications
33	FSHR	follicle stimulating hormone receptor	11.0	Publications
34	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0
35	LIPC	lipase, hepatic	11.0	Publications
36	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
37	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
38	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
39	G6PD	glucose-6-phosphate dehydrogenase	11.0
40	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
41	GH1	growth hormone 1	11.0	Publications
42	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
43	DUOXA2	dual oxidase maturation factor 2	11.0	Publications
44	DIO3	deiodinase, iodothyronine, type III	11.0	Publications
45	DUOXA1	dual oxidase maturation factor 1	11.0
46	ERP29	endoplasmic reticulum protein 29	11.0	Publications
47	TRHR	thyrotropin-releasing hormone receptor	11.0	Publications
48	HESX1	HESX homeobox 1	11.0	Publications
49	PDIA4	protein disulfide isomerase family A, member 4	11.0	Publications
50	SLC5A7	solute carrier family 5 (choline transporter), member 7	11.0

Pathways related to hypothyroidism according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	10.6	CRP, ALB, F8, APOB, APOA2, APOA1
2	Adipocytokines & Insulin Signaling37	10.5	ADIPOQ, INS, FOS, LEP, NAMPT, SERPINA12
3	Statin Pathway, Pharmacodynamics34	10.3	CYP7A1, APOE, APOB, APOA1, MTTP, LDLR
4	RAR-Gamma-RXR-Alpha Degradation36	10.3	CXCL9, CXCL12, CXCL11, LTA, IL2, LIF
5	Blood Coagulation Signaling Pathways37	10.1	THBD, F2, F3, F8, F9, SERPINE1
6	Complement and coagulation cascades20	10.1	C3, CPB2, THBD, F2, F3, F8
7	Selected targets of C/EBPalpha10	10.1	ADIPOQ, TF, ALB, F9, APOB, CD36
8	IL-6 Pathway36	10.0	CXCL9, CXCL11, CXCL10, IL5, IL4, IL10
9	OX40 Pathway36	9.8	LTA, IL5, IL4, IL13
10	Autoimmune thyroid disease20	9.5	TG, CGA, IL10, IL2, IL4, IL5
11	Asthma20	9.4	TNF, HLA-DRB1, HLA-DQB1, IL5, IL4, IL13
12	Jak-STAT signaling pathway20	9.4	EPO, PRL, TPO, GH1, IFNA2, IFNA1
13	Apoptotic Pathways in Synovial Fibroblasts36	9.3	CXCL12, TGFB1, LTA, TNF, GHRH, GH1
14	THC Differentiation Pathway36	9.3	TNF, HLA-DRB1, HLA-DQB1, IL4, IL2RA, IL2
15	Rho Family GTPases36	9.3	PTK7, LTA, TGFB1, DES, CXCL10, CXCL11
16	Leishmaniasis20	9.3	C3, TGFB1, NOS2, TNF, HLA-DRB1, HLA-DQB1
17	Selected targets of GCR-alpha10	9.2	THBD, TRHR, IL6, IL5, IL4, INS
18	Type I diabetes mellitus20	9.1	GAD2, LTA, TNF, HLA-DRB1, HLA-DQB1, IL2
19	Allograft rejection20	9.1	TNF, HLA-DRB1, HLA-DQB1, IL5, IL4, IL2
20	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	TGFB1, IL6, IL5, IL4, IL13
21	Hypertrophic cardiomyopathy (HCM)20	8.9	MYH6, DES, TGFB1, ACE, DMD, TNNT2
22	Chagas disease (American trypanosomiasis)20	8.8	TNF, NOS2, ACE, TGFB1, C3, CALR
23	Akt Signaling36	8.7	LTA, CXCL10, CXCL11, CXCL12, CXCL9, CXCR4
24	Cytokine Network36	8.6	IFNA1, IFNA2, TNF, LTA, IL6, IL5
25	all-trans-Retinoic Acid Signaling in Brain36	8.6	TNF, LTA, CXCL10, CXCL11, CXCL12, CXCL9
26	MIF Mediated Glucocorticoid Regulation36	8.6	CXCL9, CXCL12, CXCL11, CXCL10, LTA, TNF
27	p53 Mediated Apoptosis36	8.5	TGFB1, PTEN, GHRH, GH1, CASP3, GNRH1
28	MIF Regulation of Innate Immune Cells36	8.5	TNF, LTA, CXCL10, CXCL11, CXCL12, CXCL9
29	PEDF Induced Signaling36	8.5	TNF, LTA, CXCL10, CXCL11, CXCL12, CXCL9
30	Hematopoietic cell lineage20	8.4	EPO, TNF, TPO, HLA-DRB1, ANPEP, IL6
31	STAT3 Pathway36	8.4	LTA, CXCL10, CXCL11, CXCL12, CXCL9, CXCR4
32	TGF-Beta Pathway36	8.4	IGF1, GNRH1, GH1, GHRH, TGFB1, CXCL12
33	ERK Signaling36	8.3	PTK7, TGFB1, CXCL10, CXCL11, CXCL12, CXCL9
34	Antioxidant Action of Vitamin-C36	8.3	TGFB1, LTA, PLA2G7, TNF, CXCL10, CXCL11
35	Tuberculosis20	8.2	C3, TGFB1, NOS2, PPP3CA, TNF, HLA-DRB1
36	Endothelin-1 Signaling Pathway36	8.2	CXCL9, CXCL12, CXCL11, CXCL10, PTK7, CASP3
37	Molecular Mechanisms of Cancer36	8.2	GHRH, PTEN, PTK7, LTA, TGFB1, CXCL11
38	PAK Pathway36	8.2	GHRH, TNF, LTA, TGFB1, CXCL10, CXCL11
39	Tec Kinases Signaling36	8.0	GNRH1, GH1, GHRH, TNF, TGFB1, CXCL12
40	Rheumatoid arthritis20	7.9	CXCL12, TGFB1, CTLA4, TNF, HLA-DRB1, HLA-DQB1
41	p38 Signaling36	7.9	GHRH, TNF, PTK7, LTA, TGFB1, CXCL10
42	Intestinal immune network for IgA production20	7.9	CXCR4, CXCL12, TGFB1, HLA-DRB1, HLA-DQB1, IL6
43	JAK-STAT Pathway36	7.6	GNRH1, GH1, GHRH, PTK7, TGFB1, PRL
44	Cytokine-cytokine receptor interaction20	7.3	CXCL12, CXCL9, CXCR4, EPO, CXCL11, CXCL10
45	Transcription Role of VDR in regulation of genes involved in osteoporosis10	INF	CALCA, TNF, TNFRSF11B, , RUNX2, CALR
46	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	INF	CALCA, TNF, TNFRSF11B, , RUNX2, CALR

Compounds related to hypothyroidism according to GeneDecks:

(show top 50)    (show all 528)

id	Compound	Score	Top Affiliating Genes
1	gnrh32	11.1	SERPINE1, PBX1, LHX3, LEP, CGB5, FSHR
2	iodine32 18	12.0	SERPINA7, GNAS, TRH, TPO, DUOX2, DIO1
3	125i32	10.9	SERPINA7, VIP, LPO, LIPC, LDLR, APOA2
4	cyclophosphamide32 34 9 9	13.8	F9, F8, CXCL9, NPPB
5	ghrp32	10.6	PBX1, IGFBP3, IGF1, GH1, GHRH, GHRHR
6	methionine32	10.6	VWF, LPA, LPO, LIF, LIPC, CHGA
7	clonidine32 9 9	12.5	REN, BGLAP, LEP, CHGA, CGA, IGFBP3
8	urea32 9 18 9	13.5	PIK3C2A, RETN, SERPINA7, LPA, CHKB, P4HB
9	niacin32 9 9	12.4	COG2, SERPINA7, NAMPT, LPA, LPL, CHKA
10	ezetimibe32 9 9	12.4	COG2, CHKA, LDLR, MTTP, CETP, INS
11	nacl32	10.4	REN, LIF, LIPC, CHKB, F9, F8
12	corticosterone32 18	11.3	SERPINA7, VIP, LIF, BGLAP, CGB5, MPO
13	malondialdehyde32	10.2	PIK3C2A, COG2, LPA, CHKA, CHKB, MPO
14	lycopene32 18	11.1	LPL, RARA, LDLR, CETP, GSR, IGFBP3
15	fatty acid32	10.0	PIK3C2A, COG2, RETN, GCK, BTD, RBP4
16	sodium32 18	11.0	PIK3C2A, REN, RETN, LPO, PAX8, B2M
17	adenine32 9 18 9	13.0	VWF, LEP, LDLR, MTTP, GSR, APC
18	acth32	9.9	PIK3C2A, REN, SERPINA7, VIP, PBX1, LEP
19	h2o232	9.7	VWF, GCK, VIP, LPA, LPO, LIF
20	phosphatidylcholine32	9.7	SELE, VIP, LPA, LPL, LIPC, CHKA
21	rosuvastatin32 34 9 9	12.7	COG2, CHKB, LDLR, CETP, INS, IL6
22	ascorbic acid32 18	10.6	RBP4, LPO, VDR, LIF, BGLAP, CHKA
23	rituximab32 34 9 9	12.6	CD79A, IL10, IL13, IL2, IL2RA, F9
24	superoxide32 18	10.6	PIK3C2A, LPA, LPO, LIF, LIPC, CHKA
25	cysteine32	9.5	KIR2DS4, GCK, BTD, RBP4, SELP, LPA
26	iron32 18	10.5	PIK3C2A, COG2, RBP4, SERPINA7, LPO, B2M
27	agarose32	9.5	VWF, SERPINA7, LPA, LIF, CHKB, UCP2
28	atp32	9.5	PIK3C2A, GCK, LIF, LIPC, CHKA, CHKB
29	vitamin a32 9 18 9	12.5	RETN, VWF, RBP4, SERPINA7, LPL, VDR
30	captopril32 42 9 9	12.4	REN, VIP, B2M, CD79A, APOA1, APOB
31	polyethylene glycol32	9.4	SELE, SERPINC1, VIP, CHKB, P4HB, MPO
32	kininogen32	9.2	REN, VWF, SELP, SERPINC1, SERPINE1, MPO
33	desmopressin32 42 9 9	12.2	REN, VWF, SELP, SERPINC1, SERPINE1, B2M
34	epinephrine32 9 18 9	11.7	PIK3C2A, REN, SELE, SELP, VIP, LPO
35	arginine32	8.6	PIK3C2A, COG2, REN, VWF, GCK, BTD
36	lamivudine32 9 9	10.4	LPL, LEP, B2M, CD36, IL10, IL2RA
37	norepinephrine32 9 18 9	11.2	PIK3C2A, REN, RETN, VWF, SELE, SELP
38	aspirin32 34 18	10.0	COG2, VWF, SELE, SELP, SERPINC1, SERPINA7
39	thymidine32 18	8.8	VIP, VDR, RARA, LIF, CHKA, CHKB
40	prednisolone32 9 9	9.7	PIK3C2A, VWF, VIP, BGLAP, CHKB, MPO
41	infliximab32 9 9	9.7	SELE, VEGFA, BGLAP, IL10, IL2RA, IL4
42	rantes32	7.6	SELE, SELP, VIP, LIF, IL10, IL13
43	rosiglitazone32 9 18 9	10.6	COG2, RETN, RBP4, SELE, SERPINE1, NAMPT
44	cholesterol32 9 18 9	10.6	PIK3C2A, LRPAP1, COG2, REN, RETN, VWF
45	thalidomide32 42 9 9	10.6	VEGFA, B2M, CD36, IL10, IL2, IL5
46	alanine32	7.6	PIK3C2A, COG2, RETN, VWF, GCK, BTD
47	sb 20358032 42	8.2	SELE, VEGFA, VDR, LIF, BGLAP, CD36
48	indomethacin32 9 9	8.4	REN, VIP, LPL, LEP, LDLR, B2M
49	progesterone32 42 9 18 9	INF	GCK, RBP4, SERPINA7, RARA, LIF, PBX1
50	isoproterenol32 9 9	INF	LIF, CHGA, UCP2, CGB5, IL13, IL5

Cellular components related to hypothyroidism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	9.9	APOE, APOA2, APOA1, CETP, LIPC, PON1
2	endoplasmic reticulum lumen	GO:005788	9.8	PDIA4, ERP29, GHRL, CALR, F2, F9
3	secretory granule	GO:030141	9.3	GHRL, TRH, TF, DBH, POMC, GHRHR
4	cell surface	GO:009986	8.6	TPO, TNF, PTPRJ, DMD, THBD, TGFB1
5	external side of plasma membrane	GO:009897	8.4	TNF, CTLA4, ACE, CXCL10, CXCL12, CXCL9
6	plasma membrane	GO:005886	6.8	DIO1, DIO2, DIO3, CTLA4, ACE, ACHE
7	extracellular region	GO:005576	5.8	GAST, EPO, LRPAP1, IL13, IL2, IL5
8	extracellular space	GO:005615	4.1	MPO, INS, IL10, IL13, IL2, IL4

Biological processes related to hypothyroidism according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	thyroid hormone generation	GO:006590	11.4	SLC5A5, IYD, FOXE1, TPO, DUOX1, DUOX2
2	hormone biosynthetic process	GO:042446	11.2	TG, DIO3, DIO2, DIO1, DUOX2, DUOX1
3	low-density lipoprotein particle remodeling	GO:034374	10.8	PLA2G7, APOB, APOA2, MPO, CETP, LIPC
4	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.7	GHRHR, GHRH, GH1, IGF1, IGFBP3
5	cellular nitrogen compound metabolic process	GO:034641	10.4	AGXT, TSHB, DBH, POMC, SLC5A5, DIO3
6	response to estrogen stimulus	GO:043627	10.4	EPO, TSHB, TNFRSF11B, GHRL, GHRHR, APOA2
7	lipoprotein metabolic process	GO:042157	10.3	ALB, APOE, APOB, APOA2, APOA1, CETP
8	response to estradiol stimulus	GO:032355	10.3	NKX2-5, VDR, RARA, IGFBP2, F3, CALR
9	female pregnancy	GO:007565	10.1	TGFB1, TFCP2L1, PSG2, PRL, NPPA, ADM
10	cell-cell signaling	GO:007267	10.1	LTA, TSHR, TSHB, CXCL10, CXCL11, CXCL9
11	response to ethanol	GO:045471	10.0	BGLAP, IL13, IL4, GNRH1, TRH, SOD1
12	cholesterol transport	GO:030301	10.0	APOB, APOA1, CD36, CETP, LDLR
13	lipid metabolic process	GO:006629	9.9	APOA1, APOA2, APOB, APOE, ALB, G6PD
14	cholesterol metabolic process	GO:008203	9.9	APOE, APOB, APOA2, APOA1, IL4, CETP
15	regulation of blood pressure	GO:008217	9.9	POMC, NPPA, NPPB, MYH6, SOD1, ACE
16	response to lipopolysaccharide	GO:032496	9.8	EPO, ADM, NKX2-1, CXCL10, THBD, LTA
17	small molecule metabolic process	GO:044281	9.8	POMC, SLC5A5, SLC25A13, NEU1, ADA, CS
18	G-protein coupled receptor signaling pathway	GO:007186	9.7	TSHB, CXCL12, CXCL9, CXCR4, C3, ADRA1B
19	aging	GO:007568	9.7	ADA, ADM, TGFB1, CALCA, F3, IGFBP2
20	response to glucocorticoid stimulus	GO:051384	9.6	ADIPOQ, ADM, AGXT, TNF, GHRHR, HSD11B2
21	positive regulation of MAPK cascade	GO:043410	9.3	ADRA1B, IGF1, IGFBP3, IL6, INS, CD36
22	immune response	GO:006955	9.1	HLA-DQB1, HLA-DRB1, CTLA4, CXCL10, CXCL11, CXCL12
23	response to hypoxia	GO:001666	9.1	CXCL12, CXCR4, NPPB, ADM, ADA, ADIPOQ
24	response to drug	GO:042493	9.0	B2M, IL10, IL4, APC, APOA2, IGFBP2
25	positive regulation of transcription, DNA-dependent	GO:045893	8.9	AIRE, TNF, TGFB1, TFAM, POU1F1, RUNX2
26	platelet degranulation	GO:002576	8.9	F8, ALB, TGFB1, TF, SOD1, IGF1
27	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.4	ADIPOQ, GH1, IGF1, IL6, IL5, INS
28	positive regulation of cell proliferation	GO:008284	8.2	PTEN, GHRHR, GHRH, CALR, TSHR, TGFB1
29	blood coagulation	GO:007596	8.1	F3, F2, ALB, GNAS, NOS2, THBD
30	inflammatory response	GO:006954	8.1	CRP, TGFB1, CXCL10, CXCL11, CXCL9, CXCR4
31	negative regulation of apoptotic process	GO:043066	7.8	GHRL, TNF, PTEN, PROP1, CXCL12, NKX2-5
32	platelet activation	GO:030168	7.7	F8, F2, ALB, TGFB1, TF, SOD1
33	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IGF1, GLIS3, AIRE, TNF, , TGFB1
34	glucose homeostasis	GO:042593	INF	ADIPOQ, ADRA1B, DBH, , INS, SERPINE1
35	cholesterol homeostasis	GO:042632	INF	CYP7A1, , APOE, APOB, APOA2, APOA1
36	thyroid gland development	GO:030878	INF	NKX2-5, NKX2-1, TG, , DUOX2, FOXE1

Molecular functions related to hypothyroidism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	9.8	GAST, TSHB, TG, PRL, POMC, NPPA
2	receptor binding	GO:005102	9.0	CXCL10, CXCL12, POMC, NPPA, NPPB, C3
3	growth factor activity	GO:008083	7.3	TGFB1, GH1, F2, IGF1, IL6, IL5
4	cytokine activity	GO:005125	7.1	IFNA2, TNF, TNFRSF11B, LTA, CXCL9, ADIPOQ
5	protein binding	GO:005515	INF	CRH, CRP, NOS2, PDIA4, ACE, ACHE