MCID: HYP086
MIFTS: 68

Hypothyroidism malady

Endocrine diseases category

Summaries for Hypothyroidism

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. it is one of your endocrine glands, which make hormones. thyroid hormones control the rate of many activities in your body. these include how fast you burn calories and how fast your heart beats. all of these activities are your body's metabolism. thyroid problems include goiter - enlargement of the thyroid gland hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs hypothyroidism - when your thyroid gland does not make enough thyroid hormones thyroid cancer thyroid nodules - lumps in the thyroid gland thyroiditis - swelling of the thyroid dept. of health and human services office on women's health

MalaCards: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and thyroiditis. An important gene associated with Hypothyroidism is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The drug kelp preparation and the compounds tyrosine and iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia:63 Hypothyroidism (/ˌhaɪpɵˈθaɪərɔɪdɪzəm/), from hypo- (\"under\" in Greek) and thyroid (the... more...

Aliases & Classifications for Hypothyroidism

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8Disease Ontology, 63Wikipedia, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

hypothyroidism 8 10 44 33 60
thyroid diseases 44 33 60
thyroid insufficiency 8
dysfunction thyroid 44
thyroid dysfunction 60
thyroid deficiency 8
thyroid disease 63


External Ids:

Disease Ontology8 DOID:1459
NCIt39 C26800
ICD9CM27 244.9
MeSH34 D007037
UMLS60 C002067

Related Diseases for Hypothyroidism

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia family:

Congenital Hypothyroidism hypothyroidism
Familial Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duox2-Related Congenital Hypothyroidism, Iyd-Related
Congenital Hypothyroidism, Tpo-Related Hypothyroidism, Autoimmune
Transient Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 488)
idRelated DiseaseScoreTop Affiliating Genes
1congenital hypothyroidism31.7TPO, TG, TSHR, TSHB, SERPINA7, GNAS
2thyroiditis31.5TSHR, SERPINA7, TRH, CTLA4, TG, TPO
3hyperthyroidism31.0GNAS, CTLA4, TRH, SERPINA7, TSHB, TSHR
4goiter30.9GNAS, NKX2-1, TRH, PAX8, SERPINA7, TSHB
5autoimmune thyroiditis30.8TG, TPO
6myxedema30.7TPO, TG, TSHR
7hepatitis30.6SERPINA7, CTLA4
8graves' disease30.6GNAS, TSHR
9thyrotoxicosis30.5TRH, SERPINA7, TG, TPO, TSHR
10diabetes mellitus30.5CTLA4
11adenoma30.4TRH, POU1F1, GNAS, CTLA4, TSHB, TSHR
12subacute thyroiditis30.4TSHR, TG, TPO
13celiac disease30.3CTLA4, TPO, TG
14thyroid cancer30.2SLC5A5, GNAS, NKX2-1, TG, PAX8, TRH
15pituitary adenoma30.2GNAS, TRH, POU1F1, SERPINA7, TSHB
16hypoparathyroidism30.2CTLA4
17infertility30.2PAX8, TPO
18dwarfism30.1POU1F1
19alopecia30.1BTD
20pendred syndrome30.1PAX8, TG, TPO, DUOX2
21endemic goiter30.1TPO, TSHR, TG
22diabetes insipidus30.1TRH
23papillary carcinoma30.0TPO, TSHR, NKX2-1, GNAS, PAX8, TG
24papillary thyroid carcinoma30.0TG, TPO, PAX8, TSHR
25candidiasis30.0BTD
26neonatal thyrotoxicosis30.0TSHR
27hyperthyroxinemia29.9TSHR, TPO, TRH, SERPINA7
28struma ovarii29.9NKX2-1, TG, TSHR
29addison's disease29.9TG, TPO, CTLA4
30deficiency anemia29.9TRH, GNAS, SERPINA7
31breast cancer29.9POU1F1, CTLA4
32multinodular goiter29.8TSHR, TG, TPO, GNAS
33nodular goiter29.8TSHR, TPO, TG, CTLA4
34toxic diffuse goiter29.8TG, TPO, TSHR
35turner syndrome29.8TPO, TG, SERPINA7
36acromegaly29.8TRH, GNAS
37pernicious anemia29.8TG, TPO
38thymoma29.8CTLA4, NKX2-1
39euthyroid sick syndrome29.8SERPINA7, TRH
40exophthalmos29.8TSHR, TRH
41follicular adenoma29.7GNAS, NKX2-1, PAX8, TSHR, TPO, TG
42thyroid agenesis29.6NKX2-1, FOXE1, TG, TSHR, SERPINA7, PAX8
43thyrotropin deficiency, isolated29.6POU1F1, TSHB, TPO, TG
44plummer's disease29.6TPO, TG
45endogenous depression29.6TRH
46cushing's syndrome29.6TRH
47kidney cancer29.6PAX8, NKX2-1, CTLA4, GNAS
48iodine hypothyroidism10.6
49congenital hypothyroidism, nongoitrous 110.3
50myopathy10.3

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to hypothyroidism

Clinical Features for Hypothyroidism

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Drugs & Therapeutics for Hypothyroidism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hypothyroidism

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism

Search NIH Clinical Center for Hypothyroidism

Search CenterWatch for Hypothyroidism

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hypothyroidism

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Anatomical Context for Hypothyroidism

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32MalaCards
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MalaCards organs/tissues related to Hypothyroidism:

32
Thyroid, Testes, Heart, Pituitary, Brain, Bone, Kidney, Ovary, Testis, Liver, Cortex, Endothelial, Breast, Skin, Salivary gland, Lung, Eye, Spinal cord, Skeletal muscle, Colon, Smooth muscle, Fetal thyroid, Hypothalamus, Retina, T cells, Prostate, Uterus, Bone marrow, Pancreatic islet

Animal Models for Hypothyroidism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypothyroidism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.6DUOX2, NKX2-1, NKX2-5, CTLA4, FOXE1, GNAS
2MP:000537911.5TG, GNAS, FOXE1, CTLA4, NKX2-1, DUOX2
3MP:000363111.3NKX2-1, NRGN, DUOX2, TRH, POU1F1, PAX8
4MP:000537811.2GNAS, NKX2-5, NKX2-1, DUOX2, TRH, POU1F1

Publications for Hypothyroidism

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Sources:
50PubMed
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Articles related to Hypothyroidism:

(show top 50)    (show all 2069)
idTitleAuthorsYear
1
Developmental Hypothyroxinemia and Hypothyroidism Reduce Proliferation of Cerebellar Granule Neuron Precursors in Rat Offspring by Downregulation of the Sonic Hedgehog Signaling Pathway. (24264724)
2013
2
Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables. (24174944)
2013
3
Assessment of the elasticity properties of the ascending aorta in patients with subclinical hypothyroidism by tissue Doppler imaging. (23896808)
2013
4
TSH reference limits: new concepts and implications for diagnosis of subclinical hypothyroidism. (24014005)
2013
5
A clinical study of the cutaneous manifestations of hypothyroidism in kashmir valley. (23919021)
2013
6
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. (24064777)
2013
7
Effect of prolonged discontinuation of L-thyroxine replacement in a child with congenital hypothyroidism. (22953072)
2012
8
Choreoathetosis, congenital hypothyroidism and neonatal respiratory distress syndrome with intact NKX2-1. (23169673)
2012
9
Phenylketonuria, congenital hypothyroidism and haemoglobinopathies: public health issues for a Brazilian newborn screening program. (23033178)
2012
10
Clinical and genetic analysis of a compound heterozygous mutation in the thyroglobulin gene in a Chinese twin family with congenital goiter and hypothyroidism. (22784463)
2012
11
Fabry disease superimposed on overt autoimmune hypothyroidism. (23926402)
2011
12
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
13
Neonatal sludge: a finding of congenital hypothyroidism. (21274296)
2009
14
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter. (19306478)
2009
15
The -590CC genotype in the IL4 gene as a strong predictive factor for the development of hypothyroidism in Hashimoto disease. (18310157)
2008
16
Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones concentrations. (18283268)
2008
17
A molecular analysis and long-term follow-up of two siblings with severe congenital hypothyroidism carrying the IVS30+1G>T intronic thyroglobulin mutation. (19169491)
2008
18
A novel NKX2.1 mutation in a family with hypothyroidism and benign hereditary chorea. (18788921)
2008
19
Autoimmune thyroiditis and acquired hypothyroidism in an infant with severe combined immunodeficiency due to adenosine deaminase deficiency. (17614781)
2007
20
Thyroxine replacement in an animal model of congenital hypothyroidism. (17445845)
2007
21
Obesity and attenuated adiposity rebound in children with congenital hypothyroidism. Normalization of BMI values in adolescents. (17611907)
2007
22
Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. (17709695)
2007
23
How should we be treating children with congenital hypothyroidism? (17642417)
2007
24
Incidence of congenital hypothyroidism and congenital adrenal hyperplasia at Flushing Hospital Medical Center. (17616041)
2007
25
Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormone. (17210747)
2007
26
Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. (17291550)
2007
27
The effects of treatment of subclinical hypothyroidism on metabolic control and hyperinsulinemia. (17582969)
2007
28
The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients. (17389707)
2007
29
Neonatal hypothyroidism alters the kinetic properties of Na+, K+-ATPase in synaptic plasma membranes from rat brain. (16750483)
2006
30
Congenital hypothyroidism in Peters plus syndrome. (16754209)
2006
31
Genetics of congenital hypothyroidism. (15863666)
2005
32
Thyroid substitution therapy induces high-density lipoprotein-associated platelet-activating factor-acetylhydrolase in patients with subclinical hypothyroidism: a potential antiatherogenic effect. (15929667)
2005
33
Neonatal hypothyroidism-induced changes in rat testis size, dependence on temperature. (16380692)
2005
34
Potent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development. (15012609)
2004
35
Tryptic peptides of canine thyroglobulin reactive with sera of patients with canine hypothyroidism caused by autoimmune thyroiditis. (15350757)
2004
36
Thyroglobulin gene mutations and other genetic defects associated with congenital hypothyroidism. (15611820)
2004
37
Soy formula complicates management of congenital hypothyroidism. (14709499)
2004
38
Hypothyroidism in siblings due to a homozygous mutation of the TSH-beta subunit gene. (15198300)
2004
39
Expression of pituitary hormones in the Pax8-/- mouse model of congenital hypothyroidism. (14617574)
2004
40
Familial congenital hypothyroidism due to loss of function mutation of the thyrotropin receptor (resistance to thyrotropin)]. (11857915)
2002
41
Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control. (10325466)
1999
42
A chronic glue sniffer with hyperchloraemia metabolic acidosis, rhabdomyolysis, irreversible quadriplegia, central pontine myelinolysis, and hypothyroidism. (8918637)
1996
43
Cardiovascular manifestations of hypothyroidism]. (1862565)
1991
44
Incidence, predictability, and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism. (1951413)
1991
45
Neonatal hypothyroidism: recent developments. (3066322)
1988
46
Iodine deficiency and neonatal hypothyroidism. (3490923)
1986
47
Multiple cutaneous focal mucinoses with hypothyroidism. (7053704)
1982
48
Co-existing Klinefelter's syndrome, sublingual thyroid, and hypothyroidism. (7108632)
1982
49
Transient neonatal hypothyroidism. (724334)
1978
50
Primary hypothyroidism in cystinosis. (874698)
1977

Genetic Variations for Hypothyroidism

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Expression for genes affiliated with Hypothyroidism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for genes affiliated with Hypothyroidism

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Hypothyroidism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1IYD, TSHR, TSHB, PAX8, SLC5A5, DUOX2
2
Hide members
10.8TSHB, TSHR, TPO, TG
3
Hide members
10.7TPO, IYD, SLC5A5
410.7TSHB, PAX8, GNAS
5
Hide members
10.7TG, TPO
6
Hide members
10.7TSHB, TSHR

Compounds for genes affiliated with Hypothyroidism

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.8GNAS, CTLA4, NKX2-1, NRGN, TRH, POU1F1
2iodide44 2412.8TG, TPO, IYD, TSHR, SERPINA7, PAX8
3ribonucleic acid4411.7GNAS, NKX2-1, POU1F1, PAX8, SERPINA7, TSHB
4iodine44 2412.7TRH, DUOX2, CTLA4, GNAS, SLC5A5, SERPINA7
5serine4411.6GNAS, CTLA4, NKX2-5, NKX2-1, BTD, PAX8
6thyroxine44 2412.6NRGN, TRH, PAX8, SERPINA7, TSHB, TSHR
7sodium44 2412.6FOXE1, NKX2-1, DUOX2, SLC5A5, PAX8, TSHR
8oligonucleotide4411.6GNAS, NKX2-1, TRH, POU1F1, SLC5A5, PAX8
9arginine4411.6GNAS, TRH, POU1F1, BTD, SERPINA7, TSHR
10glutamate4411.6GNAS, CTLA4, NRGN, TRH, POU1F1, TSHR
11alanine4411.6GNAS, FOXE1, CTLA4, POU1F1, BTD, SERPINA7
12estrogen4411.6CTLA4, NKX2-1, TRH, POU1F1, SERPINA7, TSHB
13sodium iodide4411.5TG, TPO, TSHR, PAX8, SLC5A5, DUOX2
14acth4411.5GNAS, TRH, POU1F1, SERPINA7, TSHB, TSHR
15forskolin44 49 1113.5GNAS, NKX2-1, TRH, POU1F1, PAX8, TSHR
16thymidine44 2412.5GNAS, CTLA4, TRH, POU1F1, TSHB, TSHR
17retinoic acid44 2412.4NKX2-1, NRGN, POU1F1, TSHB, TSHR, TPO
18triiodothyronine4411.4TRH, SERPINA7, TSHB, TSHR, TPO, TG
19progesterone44 59 28 11 2415.3GNAS, NKX2-1, TRH, POU1F1, SERPINA7, TSHR
20125i4411.3SLC5A5, SERPINA7, TSHR, TPO, TG
21methimazole44 2 1113.3TRH, SERPINA7, TSHR, TPO, TG
22steroid4411.3GNAS, CTLA4, NKX2-1, POU1F1, SERPINA7, TPO
23threonine4411.3GNAS, CTLA4, NKX2-1, PAX8, SERPINA7, TSHR
24perchlorate4411.2TG, TPO, SLC5A5, DUOX2
25calcium44 49 11 2414.2GNAS, CTLA4, NRGN, DUOX2, TRH, POU1F1
26cysteine4411.2GNAS, CTLA4, BTD, TSHR, TPO, TG
27asparagine4411.2GNAS, SERPINA7, TSHR, TPO
28adenylate4411.2GNAS, TRH, TSHR, TPO, TG
29glucose4411.2GNAS, CTLA4, TRH, BTD, SERPINA7, TSHR
30cyclic amp44 2412.2TSHR, POU1F1, TRH, NKX2-1, GNAS
31sialic acid4411.2GNAS, SERPINA7, TSHR, TG
32propylthiouracil44 2 1113.1TSHR, TPO, TG
33amiodarone44 49 28 1114.1SERPINA7, TPO, TG
34histidine4411.1GNAS, SERPINA7, TSHR, TPO
35polysaccharide4411.0TG, TPO, TSHR, GNAS
36octreotide44 59 28 1114.0GNAS, TRH, TG
37iodotyrosine44 2412.0TG, TPO
38diiodotyrosine4411.0TG, TPO
39acetylcholine44 49 28 11 2415.0TG, TPO, TRH, CTLA4
40carbimazole44 1111.9TPO, TSHR
41kaempferol4410.9TPO, SLC5A5
42sodium dodecylsulfate4410.9SERPINA7, TPO, TG
43hydrocortisone44 2 59 1113.7TG, TPO, TRH
44amino acid4410.7TPO, TSHR
45dexamethasone44 49 28 1113.6POU1F1, TRH, NRGN, NKX2-1, CTLA4
46Liothyronine11 2411.6SERPINA7, TPO

GO Terms for genes affiliated with Hypothyroidism

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16Gene Ontology
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Biological processes related to Hypothyroidism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659011.3TG, TPO, IYD, SLC5A5, DUOX2, FOXE1
2thyroid gland developmentGO:03087811.2FOXE1, NKX2-5, NKX2-1, PAX8, TG
3positive regulation of transcription, DNA-dependentGO:04589311.1FOXE1, NKX2-5, NKX2-1, POU1F1, PAX8
4negative regulation of transcription from RNA polymerase II promoterGO:00012211.1FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3
5hormone biosynthetic processGO:04244611.0DUOX2, TPO, TG
6iodide transportGO:01570510.9TG, SLC5A5
7cellular response to gonadotropin stimulusGO:07137110.8PAX8, SLC5A5
8anatomical structure morphogenesisGO:00965310.7TSHB, PAX8, FOXE1
9response to vitamin AGO:03318910.7SERPINA7, TSHB
10hydrogen peroxide catabolic processGO:04274410.7TPO, DUOX2
11positive regulation of transcription from RNA polymerase II promoterGO:04594410.6PAX8, GLIS3, POU1F1, NKX2-1, NKX2-5
12response to corticosterone stimulusGO:05141210.5TRH, SERPINA7

Molecular functions related to Hypothyroidism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.9FOXE1, NKX2-5, NKX2-1, POU1F1, GLIS3, PAX8
2iodide peroxidase activityGO:00444710.7TPO, IYD
3peroxidase activityGO:00460110.7TPO, DUOX2
4thyroid-stimulating hormone receptor activityGO:00499610.7TSHR, PAX8
5RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.4NKX2-1, NKX2-5, FOXE1

Products for genes affiliated with Hypothyroidism

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  • Antibodies
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  • Antibodies

Sources for Hypothyroidism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet