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MCID: HYP086
MIFTS: 62

Hypothyroidism

Categories: Endocrine diseases, Rare diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypothyroidism

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MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 12 72 28 51 40 41 14 69
Thyroid Diseases 51 40 69
Thyroid Insufficiency 12
Dysfunction Thyroid 51
Thyroid Dysfunction 69
Thyroid Deficiency 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


Sources

Summaries for Hypothyroidism

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MedlinePlus : 40 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to postsurgical hypothyroidism and hypothyroidism, congenital, nongoitrous, 4. An important gene associated with Hypothyroidism is CHD7 (Chromodomain Helicase DNA Binding Protein 7), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Selenium and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 72 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Sources

Related Diseases for Hypothyroidism

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Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 618)
# Related Disease Score Top Affiliating Genes
1 postsurgical hypothyroidism 33.8 TG TRH
2 hypothyroidism, congenital, nongoitrous, 4 33.7 TG TPO TSHB
3 hypothyroidism, congenital, nongoitrous, 2 33.5 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
4 neonatal hypothyroidism 33.3 PAX8 SLC5A5 TG TPO TSHR
5 congenital hypothyroidism 33.1 GLIS3 IYD NKX2-1 NKX2-5 PAX8 SLC5A5
6 myxedema 32.9 TG TPO TSHR
7 pendred syndrome 32.8 PAX8 SLC26A4 TG TPO
8 hashimoto thyroiditis 32.7 SLC26A4 TG TPO TSHB TSHR
9 thyroid ectopia 31.5 NKX2-5 PAX8
10 hyperthyroidism 31.4 SERPINA7 SHBG TG TPO TRH TSHR
11 subacute thyroiditis 31.4 SERPINA7 SHBG TG TPO TSHR
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.3 TG TPO TSHR
13 familial thyroid dyshormonogenesis 31.0 DUOXA2 IYD SLC5A5 TG TPO
14 athyreosis 30.8 NKX2-1 NKX2-5 PAX8 SLC26A4 TG TSHR
15 thyroiditis 30.8 SERPINA7 TG TPO TRH TSHB TSHR
16 graves' disease 30.3 SERPINA7 TG TPO TSHR
17 struma ovarii 30.2 NKX2-1 TG TSHR
18 graves disease 1 30.0 SERPINA7 TG TPO TRH TSHR
19 neonatal thyrotoxicosis 30.0 DIO3 PAX8 TSHR
20 nodular goiter 30.0 TG TPO TSHR
21 papillary carcinoma 29.8 NKX2-1 PAX8 TG TPO TSHR
22 differentiated thyroid carcinoma 29.8 NKX2-1 PAX8 TG TPO TSHR
23 plummer's disease 29.7 SHBG TG TPO
24 endemic goiter 29.7 SERPINA7 TG TPO TSHB TSHR
25 hyperthyroxinemia 29.6 SERPINA7 TPO TRH TSHR
26 hypoadrenalism 29.5 SHBG TG
27 turner syndrome 29.5 SHBG TG TPO
28 multinodular goiter 29.4 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
29 thyroid cancer 29.2 NKX2-1 PAX8 SLC26A4 SLC5A5 TG TPO
30 toxic diffuse goiter 29.1 SERPINA7 TG TPO TRH TSHR
31 goiter 28.9 DUOXA2 IYD NKX2-1 PAX8 SERPINA7 SLC26A4
32 thyroid cancer, nonmedullary, 1 28.8 DIO3 NKX2-1 PAX8 SLC5A5 TG TPO
33 hypothyroidism, congenital, nongoitrous, 1 12.4
34 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.4
35 hypothyroidism, central, and testicular enlargement 12.3
36 central congenital hypothyroidism 12.3
37 diabetes mellitus, neonatal, with congenital hypothyroidism 12.2
38 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.2
39 hypothyroidism, congenital, nongoitrous, 5 12.1
40 hypothyroidism, congenital, nongoitrous, 6 12.1
41 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 12.0
42 hypothyroidism, congenital, nongoitrous, 3 12.0
43 muscular pseudohypertrophy-hypothyroidism syndrome 11.9
44 hypothyroidism due to deficient transcription factors involved in pituitary development or function 11.9
45 idiopathic congenital hypothyroidism 11.9
46 iodine hypothyroidism 11.8
47 ectodermal dysplasia, hypohidrotic, with hypothyroidism and agenesis of the corpus callosum 11.7
48 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 11.7
49 hypothyroidism due to iodide transport defect 11.7
50 genetic transient congenital hypothyroidism 11.7

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 156)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism
Sources

Symptoms & Phenotypes for Hypothyroidism

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MGI Mouse Phenotypes related to Hypothyroidism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 TPO NKX2-5 PAX8 CHD7 SLC26A4 GLIS3
2 growth/size/body region MP:0005378 10.18 NKX2-1 TPO NKX2-5 PAX8 CHD7 DIO3
3 homeostasis/metabolism MP:0005376 10.07 NKX2-1 TPO NKX2-5 PAX8 CHD7 SLC26A4
4 hearing/vestibular/ear MP:0005377 9.8 TPO PAX8 CHD7 SLC26A4 THRA TSHR
5 nervous system MP:0003631 9.65 THRA NKX2-1 NKX2-5 PAX8 CHD7 SLC26A4
6 limbs/digits/tail MP:0005371 9.63 THRA TPO PAX8 CHD7 DUOXA2 TSHR
7 reproductive system MP:0005389 9.28 NKX2-1 PAX8 CHD7 SLC26A4 DIO3 IGSF1
Sources

Drugs & Therapeutics for Hypothyroidism

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Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 738)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
2
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 76631-46-4, 113775-47-6 5311068 56032 68602
4
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
5
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
6
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
7
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
8
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
9
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
10
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
11
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
12
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
13
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
14
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
15
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
16
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
17
Menthol Approved Phase 4,Phase 2,Not Applicable 2216-51-5 16666
18
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
19
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
20
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 5460373 44475014 11953898
21
Iron Approved Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
22
Bexarotene Approved, Investigational Phase 4,Phase 3,Early Phase 1 153559-49-0 82146
23
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
24
Testosterone Approved, Investigational Phase 4,Phase 1,Early Phase 1 58-22-0 6013
25
Dinoprost Tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
26
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 4091 14219
27
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
29
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
30
Salmon Calcitonin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 47931-85-1 16129616
31
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
32
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
33
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 657181 3911
34
Copper Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-50-8 27099
35
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
36
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
37
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 439-14-5 3016
38
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 50-28-2 5757
39
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
40
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
41
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
42
Sertraline Approved Phase 4,Phase 2,Phase 3,Not Applicable 79617-96-2 68617
43
Morphine Approved, Investigational Phase 4 57-27-2 5288826
44
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
45
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
46
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 38396-39-3, 2180-92-9 2474
47
Clonidine Approved Phase 4,Phase 2 4205-90-7 2803
48
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
49
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 93-14-1 3516
50
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171

Interventional clinical trials:

(show top 50) (show all 1527)

# Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
3 Post Partum Thyroiditis 2: Long Term Observations Unknown status NCT00287144 Phase 4
4 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
5 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
6 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
7 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
8 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
9 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
10 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
11 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
12 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
13 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
14 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
15 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy Unknown status NCT01779817 Phase 4
16 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
17 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
18 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
19 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial Unknown status NCT02211053 Phase 4 Levothyroxine;placebo
22 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
23 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
24 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
25 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
26 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
27 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
28 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
29 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
30 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
31 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
32 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
33 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
34 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
35 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
36 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
37 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
38 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
39 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4 No intervention
40 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
41 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
42 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
43 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
44 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
45 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
46 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
47 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
48 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4 celecoxib
49 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4 Metformin
50 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

About this section

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 28
Sources

Anatomical Context for Hypothyroidism

About this section

MalaCards organs/tissues related to Hypothyroidism:

38
Thyroid, Testes, Heart, Pituitary, Bone, Brain, Kidney
Sources

Publications for Hypothyroidism

About this section

Articles related to Hypothyroidism:

(show top 50) (show all 3123)
# Title Authors Year
1
Anesthetic considerations in a parturient with renal tubular acidosis and hypothyroidism undergoing cesarean delivery. ( 29029882 )
2018
2
Thyroid disease in children and adolescents with PTEN hamartoma tumor syndrome (PHTS). ( 29273943 )
2018
3
Association between monoallelic<i>TSHR</i>mutations and congenital hypothyroidism: a statistical approach. ( 29092890 )
2018
4
Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats. ( 29405728 )
2018
5
Congenital Hypothyroidism Due to Dyshormonogenesis in 2 Siblings. ( 29450818 )
2018
6
Adipokine expression and endothelial function in subclinical hypothyroidism rats. ( 29440225 )
2018
7
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
8
c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model. ( 29330744 )
2018
9
Congenital Hypothyroidism. ( 29405999 )
2018
10
Anesthetic issues in pregnancy with Ebstein's anomaly, hypothyroidism, and sepsis. ( 29416493 )
2018
11
EVALUATION OF DYNAMIC THIOL-DISULPHIDE HOMEOSTASIS IN CHILDREN AND ADOLESCENTS WITH NON-AUTOIMMUNE SUBCLINICAL HYPOTHYROIDISM. ( 29402856 )
2018
12
A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation. ( 29425110 )
2018
13
Evaluation of renal function in subclinical hypothyroidism. ( 29403205 )
2018
14
Primary Hypothyroidism Presenting as Bilateral Ovarian Torsion. ( 29396948 )
2018
15
Radiotherapeutic factors affecting the incidence of developing hypothyroidism after radiotherapy for head and neck squamous cell cancer. ( 29428369 )
2018
16
Mutation screening of the GLIS3 gene in a cohort of 592 Chinese patients with congenital hypothyroidism. ( 29146476 )
2018
17
Hypothyroidism during pregnancy and its association to perinatal and obstetric morbidity: a review. ( 29396214 )
2018
18
Appraisal of clinical practice guidelines on the management of hypothyroidism in pregnancy using the Appraisal of Guidelines for Research and Evaluation II instrument. ( 29445919 )
2018
19
Rectal Atresia and Congenital Hypothyroidism: An Association or Coincidence? ( 29326865 )
2018
20
The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )
2018
21
Hypothyroidism increases cyclooxygenase-2 levels and pro-inflammatory response and decreases cell proliferation and neuroblast differentiation in the hippocampus. ( 29436670 )
2018
22
Prevalence of subclinical hypothyroidism in adults visiting primary health-care setting in Riyadh. ( 29441159 )
2018
23
Subclinical hypothyroidism and incident depression in young and middle age adults. ( 29408972 )
2018
24
No evidence of a causal relationship between hypothyroidism and glaucoma: A Danish nationwide register-based cohort study. ( 29444121 )
2018
25
Subclinical and overt hypothyroidism is associated with reduced glomerular filtration rate and proteinuria: a large cross-sectional population study. ( 29391480 )
2018
26
Diagnostic re-evaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism. ( 29335252 )
2018
27
The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model. ( 29399303 )
2018
28
Is hypothyroidism in idiopathic pleuroparenchymal fibroelastosis a novel lung-thyroid syndrome? ( 29325681 )
2018
29
Mean high dose L-thyroxine treatment is efficient and safe to achieve a normal IQ in young adult patients with congenital hypothyroidism. ( 29325045 )
2018
30
Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation. ( 29434604 )
2018
31
Newborn Screening Guidelines for Congenital Hypothyroidism in India: Recommendations of the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) - Part I: Screening and Confirmation of Diagnosis. ( 29380252 )
2018
32
AL amyloidosis, hypothyroidism and reduced tissue availability of thyroid hormones by thyroid hormone-binding immunoglobulin: a new possible perspective. ( 28805259 )
2017
33
Hypothyroidism associated with nivolumab treatment of unresectable malignant melanoma. ( 28052364 )
2017
34
Primary Hypothyroid and Secondary Adrenal Insufficiency-Searching the Missing Link. ( 28571201 )
2017
35
Pediatric Hypothyroidism: Diagnosis and Treatment. ( 28534114 )
2017
36
WAGR syndrome and congenital hypothyroidism in a child with a Mosaic 11p13 deletion. ( 28398607 )
2017
37
MTHFR GENE C677T POLYMORPHISM AND LEVELS OF DNA METHYLTRASFERASES IN SUBCLINICAL HYPOTHYROIDISM. ( 28574380 )
2017
38
Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Familya8c. ( 28359061 )
2017
39
Congenital Hypothyroidism: Facts, Facets & Therapy. ( 28176629 )
2017
40
Recurrent Graves' hyperthyroidism after prolonged radioiodine-induced hypothyroidism. ( 28944001 )
2017
41
Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population. ( 28060725 )
2017
42
The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran. ( 29084139 )
2017
43
Vocal Evaluation of Children with Congenital Hypothyroidism. ( 28986152 )
2017
44
Randomized Trial Comparing Two Algorithms for Levothyroxine Dose Adjustment in Pregnant Women With Primary Hypothyroidism. ( 28911144 )
2017
45
Homozygous DUOXA2 mutation (p.Tyr138(*)) in a girl with congenital hypothyroidism and her apparently unaffected brother: Case report and review of the literature. ( 28626131 )
2017
46
Transient Hypothyroidism and Autoimmune Thyroiditis in Children with Chronic Hepatitis C Treated with Pegylated-Interferon-I+-2b and Ribavirin. ( 28953189 )
2017
47
Congenital Hypothyroidism in Neonates of a Tertiary Care Hospital. ( 29142577 )
2017
48
The Effects of Hydroalcoholic Extract of<i>Nigella sativa</i>Seeds on Serum Estradiol and Prolactin Levels and obstetric Criteria due to Hypothyroidism in Rat. ( 29387677 )
2017
49
REGORAFENIB-INDUCED HYPOTHYROIDISM AND CANCER RELATED-FATIGUE: IS THERE A POTENTIAL LINK? ( 28468766 )
2017
50
Central hypothyroidism in a pediatric case of primary acute monoblastic leukemia with central nervous system infiltration: A case report. ( 28658145 )
2017
Sources

Variations for Hypothyroidism

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ClinVar genetic disease variations for Hypothyroidism:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic/Likely pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063
3 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
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Expression for Hypothyroidism

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Search GEO for disease gene expression data for Hypothyroidism.
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Pathways for Hypothyroidism

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Pathways related to Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.33 DUOXA2 IYD PAX8 SERPINA7 SLC26A4 SLC5A5
2
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.27 PAX8 TSHB TSHR
3
Amine-derived hormones 62
Show member pathways
 11.16 DIO3 IYD SLC5A5 TPO TSHB
4
Hormone ligand-binding receptors 62
10.44 TSHB TSHR
5
Thyroxine (Thyroid Hormone) Production 1
9.8 SLC5A5 TG TPO TRH TSHR
Sources

GO Terms for Hypothyroidism

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Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 THRA
2 positive regulation of multicellular organism growth GO:0040018 9.58 CHD7 DIO3 TSHR
3 hormone-mediated signaling pathway GO:0009755 9.56 THRA TRH TSHB TSHR
4 hormone biosynthetic process GO:0042446 9.5 DIO3 TG TPO
5 ventricular trabecula myocardium morphogenesis GO:0003222 9.49 CHD7 NKX2-5
6 adult heart development GO:0007512 9.48 CHD7 NKX2-5
7 cellular response to gonadotropin stimulus GO:0071371 9.46 PAX8 SLC5A5
8 thyroid hormone metabolic process GO:0042403 9.43 IYD TG
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.37 PAX8 TSHR
10 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
11 thyroid hormone generation GO:0006590 9.26 DIO3 IYD SLC5A5 TPO
12 thyroid gland development GO:0030878 9.02 NKX2-1 NKX2-5 PAX8 TG THRA

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.56 NKX2-1 NKX2-5 PAX8 THRA
2 hormone activity GO:0005179 9.5 TG TRH TSHB
3 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
4 iodide peroxidase activity GO:0004447 8.96 IYD TPO
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR
Sources

Sources for Hypothyroidism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
23