MCID: HYP324
MIFTS: 34

Hypothyroidism, Autoimmune malady

Summaries for Hypothyroidism, Autoimmune

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47OMIM, 33MalaCards
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MalaCards: Hypothyroidism, Autoimmune is related to thyroiditis and autoimmune thyroiditis. An important gene associated with Hypothyroidism, Autoimmune is IDDM12 (insulin-dependent diabetes mellitus 12), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Calcium signaling in the CD4+ TCR pathway. The compounds rantes and lysophosphatidylcholine have been mentioned in the context of this disorder. Affiliated tissues include heart, thyroid and t cells, and related mouse phenotypes are hematopoietic system and mortality/aging.

Description from OMIM:47 140300

Aliases & Classifications for Hypothyroidism, Autoimmune

Sources:
47OMIM
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Aliases & Descriptions:

hypothyroidism, autoimmune 47


Related Diseases for Hypothyroidism, Autoimmune

Sources:
17GeneCards, 18GeneDecks
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Diseases in the congenital hypothyroidism family:

hypothyroidism familial hypothyroidism
hypothyroidism due to iodide transport defect hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia
hypothyroidism, autoimmune transient congenital hypothyroidism
hypothyroidism due to deficient transcription factors involved in pituitary development or function congenital hypothyroidism due to maternal intake of antithyroid drugs
congenital hypothyroidism due to transplacental passage of maternal tsh-binding inhibitory antibodies

Diseases related to Hypothyroidism, Autoimmune via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.4TPO, CTLA4
2autoimmune thyroiditis30.4CTLA4, AIRE, IL2RA, TPO
3pendred syndrome30.0TPO
4uveitis29.9CTLA4, CXCL11, CXCL10, CXCL9, IL2RA
5deficiency anemia10.0
6n syndrome10.0
7immunodysregulation, polyendocrinopathy and enteropathy x-linked10.0
8alopecia areata10.0AIRE
9alopecia10.0AIRE
10keratoconjunctivitis10.0AIRE
11candidiasis10.0AIRE
12keratitis10.0CXCL9
13malaria10.0CXCL9
14herpes simplex10.0CXCL10
15vasculitis10.0CTLA4
16severe acute respiratory syndrome10.0CXCL10
17diabetic ketoacidosis10.0CTLA4
18myxedema10.0TPO
19goiter10.0TPO
20celiac disease 310.0CTLA4, IDDM12
21hepatitis b10.0CXCL10
22myasthenia gravis10.0AIRE, CTLA4
23hypoparathyroidism10.0CTLA4, AIRE
24diabetes mellitus10.0CTLA4, AIRE
25myocardial infarction10.0TPO
26thyrotoxicosis10.0TPO
27lichen planus10.0CXCL9, CXCL11
28thymoma10.0AIRE, CTLA4
29celiac disease10.0TPO, CTLA4
30arthropathy10.0CXCL10, CTLA4
31leukemia10.0IL2RA
32nodular goiter10.0TPO, CTLA4
33hyperthyroidism10.0TPO, CTLA4
34encephalitis10.0CXCL9, CXCL10
35influenza10.0CXCL9, CXCL10
36type 1 diabetes10.0TPO, CTLA4
37hypothyroidism10.0TPO, AIRE
38pleurisy10.0IL2RA
39colorectal cancer10.0TPO, PTPRJ
40sjogren's syndrome10.0IL2RA, CXCL9
41connective tissue disease10.0CTLA4, IL2RA
42hepatitis c10.0CTLA4, CXCL11, CXCL10
43autoimmune hepatitis10.0CTLA4, AIRE, TPO
44vitiligo10.0TPO, AIRE, CTLA4
45arthritis10.0CTLA4, CXCL10, CXCL9
46addison's disease10.0TPO, AIRE, CTLA4
47paracoccidioidomycosis10.0CXCL9, CXCL10, CTLA4
48hepatitis10.0CXCL10, AIRE, CTLA4
49allergic contact dermatitis10.0CXCL11, CXCL10, CXCL9
50skin disease10.0CXCL11, CXCL10, CXCL9

Graphical network of the top 20 diseases related to Hypothyroidism, Autoimmune:



Diseases related to hypothyroidism, autoimmune

Clinical Features for Hypothyroidism, Autoimmune

Sources:
47OMIM
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Clinical features from OMIM:

140300

Clinical synopsis from OMIM:

140300

Drugs & Therapeutics for Hypothyroidism, Autoimmune

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypothyroidism, Autoimmune

Drug clinical trials:

Search ClinicalTrials for Hypothyroidism, Autoimmune

Search NIH Clinical Center for Hypothyroidism, Autoimmune

Search CenterWatch for Hypothyroidism, Autoimmune

Genetic Tests for Hypothyroidism, Autoimmune

Anatomical Context for Hypothyroidism, Autoimmune

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypothyroidism, Autoimmune:

33
Heart, Thyroid, T cells, Endothelial, Pituitary

Animal Models for Hypothyroidism, Autoimmune or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hypothyroidism, Autoimmune:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CTLA4, AIRE, CXCL10, IL2RA, PTPRJ, TPO
2MP:00107686.8AIRE, CXCL10, CXCL9, IL2RA, PTPRJ, TPO
3MP:00053876.7TPO, CTLA4, AIRE, CXCL10, CXCL9, IL2RA

Publications for Hypothyroidism, Autoimmune

Sources:
51PubMed
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Articles related to Hypothyroidism, Autoimmune:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring. (23777566)
2013
2
Rare cases of autoimmune hypothyroidism in young children. (23612641)
2013
3
Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. (24224112)
2013
4
Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome. (23584882)
2013
5
Autoimmune Hypothyroidism Presenting as Pituitary Hyperplasia. (24072579)
2013
6
A young woman with facial oedema. Autoimmune hypothyroidism. (23723117)
2013
7
Late primary autoimmune hypothyroidism in a patient with postdelivery autoimmune hypopituitarism associated with antibodies to growth hormone and prolactin-secreting cells. (23286389)
2013
8
Multiple endocrinopathies (growth hormone deficiency, autoimmune hypothyroidism and diabetes mellitus) in Kearns-Sayre syndrome. (23947115)
2013
9
Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. (22718472)
2013
10
Novel associations for hypothyroidism include known autoimmune risk loci. (22493691)
2012
11
A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report. (23256875)
2012
12
Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. (21490407)
2011
13
More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels. (21444648)
2011
14
Pancytopenia and nephrotic syndrome related to autoimmune hypothyroidism. (21912731)
2011
15
Fabry disease superimposed on overt autoimmune hypothyroidism. (23926402)
2011
16
Clinical hypothyroidism in autoimmune pancreatitis. (20861701)
2010
17
Alopecia universalis, hypothyroidism and pituitary hyperplasia: polyglandular autoimmune syndrome III in a patient in remission from treated Hodgkin lymphoma. (22791495)
2010
18
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. (20329425)
2009
19
Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroid atrophy and autoimmune thyroiditis being distinct diseases. (19088156)
2009
20
Periodic paralysis as an unusual presentation of autoimmune hypothyroidism with goiter. (19264714)
2009
21
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. (19820021)
2009
22
Acquired von Willebrand's disease in the course of severe primary hypothyroidism in a patient with autoimmune polyglandular syndrome type 3]. (18335399)
2008
23
Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score. (18695079)
2008
24
Excess urinary iodine is associated with autoimmune subclinical hypothyroidism among Egyptian women. (18480555)
2008
25
Autoimmune thyroiditis and acquired hypothyroidism in an infant with severe combined immunodeficiency due to adenosine deaminase deficiency. (17614781)
2007
26
Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. (17468187)
2007
27
Association of HLA DQ B1* and HLA DR B1* alleles with goitrous juvenile autoimmune hypothyroidism--a case control study. (17588142)
2007
28
Primary hyperaldosteronism associated with vitiligo vulgaris and autoimmune hypothyroidism. (17496738)
2007
29
Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process. (16645011)
2006
30
Tryptic peptides of canine thyroglobulin reactive with sera of patients with canine hypothyroidism caused by autoimmune thyroiditis. (15350757)
2004
31
A case of multiple ovarian cysts in a prepubertal girl with severe hypothyroidism due to autoimmune thyroiditis. (15228431)
2004
32
Hypothyroidism and chronic autoimmune thyroiditis in the pregnant state: maternal aspects. (15157837)
2004
33
Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom. (11842815)
2002
34
Severe hypothyroidism due to autoimmune atrophic thyroiditis--predicted target height and a plausible mechanism for sexual precocity. (11515732)
2001
35
Induction of autoimmune hypothyroidism and subsequent hyperthyroidism by TSH receptor antibodies following subacute thyroiditis: a case report. (11456259)
2001
36
A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and impaired water diuresis during glucocorticoid replacement therapy. (11228040)
2000
37
Autoimmune thyroiditis with severe hypothyroidism resistant to the treatment with high peroral doses of thyroxine: case report. (11137979)
2000
38
A young woman with metabolic acidosis and recently discovered IDDM without ketonuria. A rare autoimmune (?) combination of hypothyroidism, diabetes mellitus and distal renal tubular acidosis]. (9771061)
1998
39
Simultaneously found transient hypothyroidism due to Hashimoto's thyroiditis, autoimmune hepatitis and isolated ACTH deficiency after cessation of glucocorticoid administration. (9279524)
1997
40
Parathyroid carcinoma and primary autoimmune hypothyroidism in an elderly woman. (9125488)
1997
41
Fulminant meningococcal meningitis and sepsis associated with severe hypothyroidism caused by autoimmune (Hashimoto) thyreoiditis. (9439925)
1997
42
Distal renal tubular acidosis associated with non-autoimmune hypothyroidism. (8671985)
1996
43
Identification of thyroid blocking antibodies and receptor epitopes in autoimmune hypothyroidism by affinity purification using synthetic TSH receptor peptides. (8722576)
1995
44
Subclinical hypothyroidism resulting from autoimmune thyroiditis in female patients with endogenous depression. (7868803)
1994
45
Pernicious anemia, autoimmune hypothyroidism and rapidly progressive anti-GBM glomerulonephritis. (7882606)
1994
46
Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. (8027226)
1994
47
Autoimmune hypothyroidism in a patient with generalized resistance to thyroid hormone. (8272919)
1993
48
The role of maternal autoimmune thyroid disease in neonatal hypothyroidism. (1514545)
1992
49
Intercurrent hypothyroidism, autoimmune anemia, and a coagulation deficiency (von Willebrand's disease) in a dog. (6332103)
1984
50
Bullous pemphigoid and multiple autoimmune diseases. Alopecia universalis, bullous pemphigoid, hypothyroidism, rheumatoid arthritis, and neutropenia in one patient. (6350385)
1983

Genetic Variations for Hypothyroidism, Autoimmune

Expression for genes affiliated with Hypothyroidism, Autoimmune

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypothyroidism, Autoimmune

Search GEO for disease gene expression data for Hypothyroidism, Autoimmune.

Pathways for genes affiliated with Hypothyroidism, Autoimmune

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome
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Compounds for genes affiliated with Hypothyroidism, Autoimmune

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1rantes459.9IL2RA, CXCL11
2lysophosphatidylcholine45 2910.7CXCL11, CXCL9
3groalpha459.7CXCL9, CXCL10
4con a459.7CTLA4, IL2RA
5iodine45 2410.6TPO, CTLA4
6mycophenolate mofetil45 50 1111.5IL2RA, CTLA4
7tarc459.5CXCL11, CXCL10, CXCL9
8ccl345 2910.5CXCL9, CXCL10, CXCL11
92,5-oligoadenylate459.5IL2RA, CXCL10
10ccl445 2910.5CXCL9, CXCL10, CXCL11
11infliximab45 50 1111.4IL2RA, CXCL10, CTLA4
12carbimazole45 1110.4TPO, IL2RA
13tacrolimus45 50 1111.3CTLA4, CXCL10, IL2RA
14ionomycin459.3IL2RA, CXCL9, CTLA4
15vitamin d459.2IL2RA, CXCL10, CTLA4
16ifn-alpha459.2CXCL10, CXCL9, IL2RA
17methimazole45 2 1111.1TPO, IL2RA
18nitrate459.0IL2RA, TPO
19il 10458.9IL2RA, CXCL9, CXCL10, CTLA4
20histamine45 29 2410.8IL2RA, CXCL9, CXCL10
21phosphatidylinositol458.8IL2RA, CXCL9, CXCL10, CTLA4
22dexamethasone45 50 29 1111.5CTLA4, CXCL11, CXCL10, CXCL9, IL2RA
23arginine458.4CXCL11, CXCL9, IL2RA, TPO
24acetylcholine45 50 29 11 2412.4TPO, IL2RA, CTLA4
25creatinine458.4CXCL10, CXCL9, IL2RA, TPO
26calcium45 50 11 2410.7CTLA4, CXCL11, CXCL10, CXCL9, PTPRJ, TPO
27tyrosine457.1CTLA4, AIRE, CXCL10, CXCL9, IL2RA, PTPRJ

GO Terms for genes affiliated with Hypothyroidism, Autoimmune

Sources:
16Gene Ontology
See all sources

Cellular components related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5IL2RA, CXCL9, CXCL10, CTLA4

Biological processes related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte chemotaxisGO:0026909.6CXCL10, CXCL11
2inflammatory responseGO:0069549.1CXCL9, CXCL10, CXCL11
3chemotaxisGO:0069359.0CXCL11, CXCL10, CXCL9
4cell-cell signalingGO:0072678.8CXCL9, CXCL10, CXCL11
5immune responseGO:0069557.8IL2RA, CXCL9, CXCL10, CXCL11, AIRE, CTLA4

Molecular functions related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.1CXCL9, CXCL10, CXCL11

Products for genes affiliated with Hypothyroidism, Autoimmune

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypothyroidism, Autoimmune

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet