MCID: HYP324
MIFTS: 30

Hypothyroidism, Autoimmune malady

Summaries for Hypothyroidism, Autoimmune

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis, is a disease in which the body interprets the... more...

MalaCards: Hypothyroidism, Autoimmune is related to hypothyroidism and thyroiditis. An important gene associated with Hypothyroidism, Autoimmune is IDDM12 (insulin-dependent diabetes mellitus 12), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Calcium signaling in the CD4+ TCR pathway. The compounds rantes and lysophosphatidylcholine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotypes are hematopoietic system and mortality/aging.

Description from OMIM:46 140300

Aliases & Classifications for Hypothyroidism, Autoimmune

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46OMIM
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Aliases & Descriptions:

hypothyroidism, autoimmune 46


Related Diseases for Hypothyroidism, Autoimmune

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17GeneCards, 18GeneDecks
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Diseases in the Hypothyroidism, Congenital, Due to Thyroid Dysgenesis or Hypoplasia family:

Congenital Hypothyroidism Hypothyroidism
Familial Hypothyroidism Hypothyroidism Due to Iodide Transport Defect
Congenital Hypothyroidism, Duox2-Related Congenital Hypothyroidism, Iyd-Related
Congenital Hypothyroidism, Tpo-Related hypothyroidism, autoimmune
Transient Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism, Autoimmune via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.7TPO, AIRE
2thyroiditis30.4TPO, CTLA4
3autoimmune thyroiditis30.4CTLA4, AIRE, IL2RA, TPO
4candidiasis30.0AIRE
5pendred syndrome29.9TPO
6uveitis29.9CTLA4, CXCL11, CXCL10, CXCL9, IL2RA
7deficiency anemia10.0
8von willebrand's disease10.0
9immunodysregulation, polyendocrinopathy and enteropathy x-linked10.0
10alopecia areata10.0AIRE
11alopecia10.0AIRE
12keratoconjunctivitis10.0AIRE
13keratitis10.0CXCL9
14malaria10.0CXCL9
15herpes simplex10.0CXCL10
16vasculitis10.0CTLA4
17severe acute respiratory syndrome10.0CXCL10
18diabetic ketoacidosis10.0CTLA4
19myxedema10.0TPO
20goiter10.0TPO
21celiac disease 310.0CTLA4, IDDM12
22hepatitis b10.0CXCL10
23myasthenia gravis10.0AIRE, CTLA4
24hypoparathyroidism10.0CTLA4, AIRE
25diabetes mellitus10.0CTLA4, AIRE
26myocardial infarction10.0TPO
27thyrotoxicosis10.0TPO
28lichen planus10.0CXCL9, CXCL11
29thymoma10.0AIRE, CTLA4
30celiac disease10.0TPO, CTLA4
31arthropathy10.0CXCL10, CTLA4
32leukemia10.0IL2RA
33nodular goiter10.0TPO, CTLA4
34hyperthyroidism10.0TPO, CTLA4
35encephalitis10.0CXCL9, CXCL10
36influenza10.0CXCL9, CXCL10
37type 1 diabetes10.0TPO, CTLA4
38pleurisy10.0IL2RA
39colorectal cancer10.0TPO, PTPRJ
40sjogren's syndrome10.0IL2RA, CXCL9
41connective tissue disease10.0CTLA4, IL2RA
42hepatitis c10.0CTLA4, CXCL11, CXCL10
43autoimmune hepatitis10.0CTLA4, AIRE, TPO
44vitiligo10.0TPO, AIRE, CTLA4
45arthritis10.0CTLA4, CXCL10, CXCL9
46addison's disease10.0TPO, AIRE, CTLA4
47paracoccidioidomycosis10.0CXCL9, CXCL10, CTLA4
48hepatitis10.0CXCL10, AIRE, CTLA4
49allergic contact dermatitis10.0CXCL11, CXCL10, CXCL9
50skin disease10.0CXCL11, CXCL10, CXCL9

Graphical network of the top 20 diseases related to Hypothyroidism, Autoimmune:



Diseases related to hypothyroidism, autoimmune

Clinical Features for Hypothyroidism, Autoimmune

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46OMIM
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Clinical features from OMIM:

140300

Clinical synopsis from OMIM:

140300

Drugs & Therapeutics for Hypothyroidism, Autoimmune

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypothyroidism, Autoimmune

Drug clinical trials:

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Genetic Tests for Hypothyroidism, Autoimmune

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Anatomical Context for Hypothyroidism, Autoimmune

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32MalaCards
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MalaCards organs/tissues related to Hypothyroidism, Autoimmune:

32
Thyroid

Animal Models for Hypothyroidism, Autoimmune or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypothyroidism, Autoimmune:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CTLA4, AIRE, CXCL10, IL2RA, PTPRJ, TPO
2MP:00107686.8AIRE, CXCL10, CXCL9, IL2RA, PTPRJ, TPO
3MP:00053876.7TPO, CTLA4, AIRE, CXCL10, CXCL9, IL2RA

Publications for Hypothyroidism, Autoimmune

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Genetic Variations for Hypothyroidism, Autoimmune

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Expression for genes affiliated with Hypothyroidism, Autoimmune

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypothyroidism, Autoimmune

Search GEO for disease gene expression data for Hypothyroidism, Autoimmune.

Pathways for genes affiliated with Hypothyroidism, Autoimmune

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Hypothyroidism, Autoimmune

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1rantes449.9IL2RA, CXCL11
2lysophosphatidylcholine44 2810.7CXCL11, CXCL9
3groalpha449.7CXCL9, CXCL10
4con a449.7CTLA4, IL2RA
5iodine44 2410.6TPO, CTLA4
6mycophenolate mofetil44 49 1111.5IL2RA, CTLA4
7tarc449.5CXCL11, CXCL10, CXCL9
8ccl344 2810.5CXCL9, CXCL10, CXCL11
92,5-oligoadenylate449.5IL2RA, CXCL10
10ccl444 2810.5CXCL9, CXCL10, CXCL11
11infliximab44 49 1111.4IL2RA, CXCL10, CTLA4
12carbimazole44 1110.4TPO, IL2RA
13tacrolimus44 49 1111.3CTLA4, CXCL10, IL2RA
14ionomycin449.3IL2RA, CXCL9, CTLA4
15vitamin d449.2IL2RA, CXCL10, CTLA4
16ifn-alpha449.2CXCL10, CXCL9, IL2RA
17methimazole44 2 1111.1TPO, IL2RA
18nitrate449.0IL2RA, TPO
19il 10448.9IL2RA, CXCL9, CXCL10, CTLA4
20histamine44 28 2410.8IL2RA, CXCL9, CXCL10
21phosphatidylinositol448.8IL2RA, CXCL9, CXCL10, CTLA4
22dexamethasone44 49 28 1111.5CTLA4, CXCL11, CXCL10, CXCL9, IL2RA
23arginine448.4CXCL11, CXCL9, IL2RA, TPO
24acetylcholine44 49 28 11 2412.4TPO, IL2RA, CTLA4
25creatinine448.4CXCL10, CXCL9, IL2RA, TPO
26calcium44 49 11 2410.7CTLA4, CXCL11, CXCL10, CXCL9, PTPRJ, TPO
27tyrosine447.1CTLA4, AIRE, CXCL10, CXCL9, IL2RA, PTPRJ

GO Terms for genes affiliated with Hypothyroidism, Autoimmune

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16Gene Ontology
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Cellular components related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5IL2RA, CXCL9, CXCL10, CTLA4

Biological processes related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte chemotaxisGO:0026909.6CXCL10, CXCL11
2inflammatory responseGO:0069549.1CXCL9, CXCL10, CXCL11
3chemotaxisGO:0069359.0CXCL11, CXCL10, CXCL9
4cell-cell signalingGO:0072678.8CXCL9, CXCL10, CXCL11
5immune responseGO:0069557.8IL2RA, CXCL9, CXCL10, CXCL11, AIRE, CTLA4

Molecular functions related to Hypothyroidism, Autoimmune according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.1CXCL9, CXCL10, CXCL11

Products for genes affiliated with Hypothyroidism, Autoimmune

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypothyroidism, Autoimmune

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet