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MCID: HYP087
MIFTS: 46

Hypotrichosis malady

Categories: Genetic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypotrichosis

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Aliases & Descriptions for Hypotrichosis:

Name: Hypotrichosis 12 29 42 14

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4535
MeSH 42 D007039
NCIt 47 C34720
SNOMED-CT 64 53602002 56558005
UMLS 69 C0020678
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Summaries for Hypotrichosis

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Disease Ontology : 12 A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.

MalaCards based summary : Hypotrichosis is related to hypotrichosis 3 and hypotrichosis 2. An important gene associated with Hypotrichosis is CDH3 (Cadherin 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Minoxidil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related phenotype is integument.

Wikipedia : 71 Hypotrichosis (hypo- + tricho- + -osis) is a condition of abnormal hair patterns - predominantly loss or... more...

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Related Diseases for Hypotrichosis

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Diseases in the Hypotrichosis family:

Hypotrichosis 5 Hypotrichosis 11
Hypotrichosis 7 Hypotrichosis 2
Hypotrichosis 10 Hypotrichosis 4
Hypotrichosis 9 Hypotrichosis 13
Hypotrichosis 3 Hypotrichosis 12
Hypotrichosis 8 Hypotrichosis 1
Hypotrichosis 6

Diseases related to Hypotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 hypotrichosis 3 33.2 KRT25 KRT71 KRT74 LIPH LPAR6
2 hypotrichosis 2 12.3
3 hypotrichosis 1 12.2
4 hypotrichosis-lymphedema-telangiectasia syndrome 12.2
5 hypotrichosis 8 12.2
6 hypotrichosis 7 12.2
7 hypotrichosis 6 12.2
8 hypotrichosis simplex 12.2
9 hypotrichosis, congenital, with juvenile macular dystrophy 12.1
10 hypotrichosis and recurrent skin vesicles 12.1
11 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 12.1
12 hypotrichosis 4 12.1
13 hypotrichosis 13 12.1
14 hypotrichosis 11 12.0
15 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper ige 12.0
16 hypotrichosis 12 12.0
17 hypotrichosis 5 12.0
18 hypotrichosis 10 11.9
19 hypotrichosis 9 11.9
20 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.9
21 metaphyseal dysplasia without hypotrichosis 11.9
22 marie unna congenital hypotrichosis 11.9
23 hypotrichosis simplex of the scalp 11.8
24 hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome 11.8
25 woolly hair, hypotrichosis, everted lower lip, and outstanding ears 11.7
26 juvenile macular degeneration and hypotrichosis 11.7
27 hypotrichosis-deafness syndrome 11.7
28 spondyloepimetaphyseal dysplasia with hypotrichosis 11.7
29 brachymetapody-anodontia-hypotrichosis-albinoidism 11.7
30 leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis 11.7
31 ichthyosis, congenital, autosomal recessive 11 11.6
32 hypotrichosis of eyelid 11.6
33 congenital hypotrichosis milia 11.6
34 leukomelanoderma mental redardation hypotrichosis 11.6
35 hypotrichosis-intellectual disability, lopes type 11.6
36 bazex syndrome 11.4
37 schopf-schulz-passarge syndrome 11.4
38 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 11.2
39 palmoplantar keratoderma with congenital alopecia 11.2
40 monilethrix 11.1
41 hallermann-streiff syndrome 11.1
42 cartilage-hair hypoplasia 11.1
43 alopecia 11.0
44 sc phocomelia syndrome 11.0
45 rombo syndrome 11.0
46 ectodermal dysplasia 9, hair/nail type 10.9
47 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.9
48 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.8
49 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.8
50 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.8

Graphical network of the top 20 diseases related to Hypotrichosis:



Diseases related to Hypotrichosis
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Symptoms & Phenotypes for Hypotrichosis

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MGI Mouse Phenotypes related to Hypotrichosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 CDH3 DSC3 DSG4 HR KRT25 KRT71
Sources

Drugs & Therapeutics for Hypotrichosis

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Drugs for Hypotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 213)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minoxidil Approved Phase 4,Phase 3,Phase 1,Phase 2 38304-91-5 4201
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
5
Finasteride Approved Phase 4,Phase 3,Phase 1,Phase 2 98319-26-7 57363
6
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155206-00-1 5311027
7
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
8
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
9
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
10
Hydroxychloroquine Approved Phase 4 118-42-3 3652
11
Capsaicin Approved Phase 4 404-86-4 1548943
12
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
13 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
14
Clobetasol Phase 4,Phase 3 25122-46-7 32798 5311051
15 Dermatologic Agents Phase 4,Phase 3
16 Emollients Phase 4
17 glucocorticoids Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
19 Hormones Phase 4,Phase 3,Phase 1,Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
21 Antihypertensive Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
23 Vasodilator Agents Phase 4,Phase 3,Phase 1,Phase 2
24 Anti-Asthmatic Agents Phase 4,Phase 1,Phase 2
25 Respiratory System Agents Phase 4,Phase 1,Phase 2
26 Antiemetics Phase 4
27 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 1
28 Autonomic Agents Phase 4,Phase 1,Phase 2
29 Gastrointestinal Agents Phase 4
30 Methylprednisolone acetate Phase 4
31 Methylprednisolone Hemisuccinate Phase 4
32 Neuroprotective Agents Phase 4,Phase 2
33 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Prednisolone acetate Phase 4
35 Prednisolone hemisuccinate Phase 4
36 Prednisolone phosphate Phase 4
37 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
38 Adjuvants, Immunologic Phase 4,Phase 2
39 Anti-Infective Agents Phase 4,Phase 2
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
41 triamcinolone acetonide Phase 4,Phase 2
42 Triamcinolone diacetate Phase 4,Phase 2
43 Triamcinolone hexacetonide Phase 4,Phase 2
44 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
45 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
46 Ophthalmic Solutions Phase 4,Phase 2
47 Betamethasone benzoate Phase 4
48 Betamethasone sodium phosphate Phase 4
49 Betamethasone Valerate Phase 4 2152-44-5
50 Betamethasone-17,21-dipropionate Phase 4

Interventional clinical trials:

(show top 50) (show all 205)
id Name Status NCT ID Phase
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4
2 Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo Completed NCT01387906 Phase 4
3 Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis Completed NCT00958035 Phase 4
4 Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows Completed NCT01891487 Phase 4
5 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4
6 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4
7 Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects Completed NCT01229423 Phase 4
8 Minoxidil 2% for Eyebrow Enhancement Completed NCT01672307 Phase 4
9 Minoxidil 1% for Eyebrow Enhancement Completed NCT01924000 Phase 4
10 Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4
11 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4
12 Aldara for the Treatment of Extensive Alopecia Areata Completed NCT00177021 Phase 4
13 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4
14 Response of Topical Capsaicin in Alopecia Areata Completed NCT00176969 Phase 4
15 Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5% Completed NCT00176943 Phase 4
16 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4
17 Acupuncture for Sedation in the Intensive Care Unit (ICU) Active, not recruiting NCT01362270 Phase 4
18 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Active, not recruiting NCT02999737 Phase 4
19 The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia Withdrawn NCT02483195 Phase 4
20 Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients Unknown status NCT01655108 Phase 3
21 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis Completed NCT01391273 Phase 3
22 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Chemotherapy-Induced Eyelash Hypotrichosis Completed NCT01391286 Phase 3
23 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3
24 Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin Completed NCT00907426 Phase 3
25 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed NCT01698554 Phase 3
26 Study of Bimatoprost Gel on Eyelash Growth Completed NCT01200251 Phase 3
27 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3
28 A Long-term Study to Determine Safety and Efficacy of Dutasteride in Male Subjects With Androgenetic Alopecia Completed NCT01831791 Phase 3
29 Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM) Completed NCT01590238 Phase 3
30 A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata Completed NCT01453686 Phase 3
31 Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss Completed NCT01391156 Phase 3
32 Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia Completed NCT01231607 Phase 3
33 Clinical Trial in Females for Female Pattern Hair Loss Completed NCT01226459 Phase 3
34 Clinical Trial in Females With Female Pattern Hair Loss Completed NCT01145625 Phase 3
35 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3
36 Efficacy and Safety Study to Compare Two Minoxidil Formulations on Women With Androgenetic Alopecia Completed NCT00958750 Phase 3
37 A Study To Assess The Efficacy And Safety Of Dutasteride 0.5mg Once Daily For 6 Months In The Treatment Of Male Subjects With Androgenetic Alopecia Completed NCT00441116 Phase 3
38 Effects of Finasteride on Serum Prostate-Specific Antigen (0906-111) Completed NCT00396175 Phase 3
39 A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss Completed NCT00151515 Phase 3
40 Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Completed NCT00063076 Phase 2, Phase 3
41 Study to Evaluate the Efficacy and Safety of P-3074 Topical Solution in the Treatment of Androgenetic Alopecia Recruiting NCT03004469 Phase 3
42 Topical Garlic Concentrate for Alopecia Areata in Children Recruiting NCT02691117 Phase 3
43 TREg Activation in the Treatment of the PELADE (Alopecia Areata) Recruiting NCT02557074 Phase 3
44 The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade Recruiting NCT02037191 Phase 3
45 Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata Unknown status NCT01840046 Phase 1, Phase 2
46 Excimer Light for Alopecia Areata Unknown status NCT01802177 Phase 2
47 Stem Cell Educator Therapy in Alopecia Areata Unknown status NCT01673789 Phase 1, Phase 2
48 The Efficacy in Treatment of Female Pattern Hair Loss Using 5% Minoxidil Solution Combinded With Zinc Supplement Unknown status NCT01662089 Phase 1, Phase 2
49 Study To Determine Safety & Efficacy Of Autologous Human Platelet Lysate in Androgenetic Alopecia After Hair Transplant Unknown status NCT01644422 Phase 1, Phase 2
50 A Study to Determine the Safety and Efficacy of Autologous Human Platelet Lysate for Treatment of Androgenetic Alopecia Unknown status NCT01643629 Phase 1, Phase 2

Search NIH Clinical Center for Hypotrichosis

Cochrane evidence based reviews: hypotrichosis

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Genetic Tests for Hypotrichosis

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Genetic tests related to Hypotrichosis:

id Genetic test Affiliating Genes
1 Hypotrichosis 29
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Anatomical Context for Hypotrichosis

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MalaCards organs/tissues related to Hypotrichosis:

39
Skin, Bone, Thyroid
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Publications for Hypotrichosis

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Articles related to Hypotrichosis:

(show top 50) (show all 288)
id Title Authors Year
1
New CDH3 mutation in the first Spanish case of hypotrichosis with juvenile macular dystrophy, a case report. ( 28061825 )
2017
2
Phenotypic observations in "hypotrichosis with juvenile macular dystrophy" (recessive CDH3 mutations). ( 26885695 )
2016
3
Novel homozygous sequence variants in the CDH3 gene encoding P-cadherin underlying hypotrichosis with juvenile macular dystrophy in consanguineous families. ( 27456782 )
2016
4
Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy. ( 27157923 )
2016
5
Bimatoprost 0.03% for the Treatment of Eyebrow Hypotrichosis. ( 27124878 )
2016
6
Mutational analysis of 29 patients with autosomal recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal recessive woolly hair and hypotrichosis in Japan. ( 27641630 )
2016
7
Hypotrichosis with juvenile macular dystrophy: Portuguese case. ( 27617529 )
2016
8
Case of autosomal recessive woolly hair/hypotrichosis with atopic dermatitis. ( 27774676 )
2016
9
Diffuse hypotrichosis from early childhood. ( 27646750 )
2016
10
Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>A LIPH mutation. ( 27375176 )
2016
11
Characterization of CDH3-Related Congenital Hypotrichosis With Juvenile Macular Dystrophy. ( 27386845 )
2016
12
Novel p.Glu519Gln missense mutation in ST14 in a patient with ichthyosis, follicular atrophoderma and hypotrichosis and review of the literature. ( 26596219 )
2016
13
A novel SOX18 mutation uncovered in Jordanian patient with hypotrichosis-lymphedema-telangiectasia syndrome by Whole Exome Sequencing. ( 26631803 )
2016
14
Topical cetirizine and oral vitamin D: a valid treatment for hypotrichosis caused by ectodermal dysplasia. ( 27504742 )
2016
15
Frameshift Sequence Variants in the Human Lipase-H Gene Causing Hypotrichosis. ( 26645693 )
2016
16
Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles. ( 26902920 )
2016
17
Bimatoprost solution 0.03% topical application to the eyelid margin for the treatment of eyelash hypotrichosis. ( 26873623 )
2016
18
Hypotrichosis, milia, brachydactyly, and frenula. ( 26177262 )
2015
19
Exome sequencing reveals novel BCS1L mutations in siblings with hearing loss and hypotrichosis. ( 25895478 )
2015
20
Novel mutation in LIPH in a Lebanese patient with autosomal recessive woolly hair/hypotrichosis. ( 26046953 )
2015
21
Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome. ( 26370416 )
2015
22
A case of hypotrichosis with juvenile macular dystrophy. ( 25621871 )
2015
23
Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations. ( 25819726 )
2015
24
A Deletion in FOXN1 Is Associated with a Syndrome Characterized by Congenital Hypotrichosis and Short Life Expectancy in Birman Cats. ( 25781316 )
2015
25
Identification of a novel mutation, c.686delAins18 (p.Asp229Glyfs*22), in the LIPH gene as a compound heterozygote with c.736T>A (p.Cys246Ser) in autosomal recessive woolly hair/hypotrichosis. ( 25899282 )
2015
26
Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6. ( 25828854 )
2015
27
Bimatoprost 0.03% for the Treatment of Eyelash Hypotrichosis: A Pooled Safety Analysis of Six Randomized, Double-masked Clinical Trials. ( 26203317 )
2015
28
Novel D323G mutation of DSG4 gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix. ( 26173648 )
2015
29
Identification of mutations in U2HR in two Chinese families with Marie Unna hereditary hypotrichosis. ( 26269244 )
2015
30
Aortic Dilatation Associated With a De Novo Mutation inA theA SOX18 Gene: Expanding the Clinical Spectrum ofA Hypotrichosis-Lymphedema-Telangiectasia Syndrome. ( 26148450 )
2015
31
Management of hypotrichosis of the eyelashes: focus on bimatoprost. ( 26020474 )
2015
32
Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1-q32.2. ( 25999149 )
2015
33
In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis. ( 25119526 )
2014
34
Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations. ( 24586639 )
2014
35
Genetic dissection of two Pakistani families with consanguineous localized autosomal recessive hypotrichosis (LAH). ( 25429336 )
2014
36
Hypotrichosis-lymphedema-telangiectasia-renal defect associated with a truncating mutation in the SOX18 gene. ( 24697860 )
2014
37
A homozygous mutation, c.736T>A (p.C246S), in LIPH gene in a patient manifesting woolly hair, hypotrichosis, hearing difficulty, cleft palate and amblyopia. ( 24722066 )
2014
38
Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis. ( 24714551 )
2014
39
Identification of a novel U2HR mutation in a Korean woman with Marie Unna hereditary hypotrichosis. ( 24961381 )
2014
40
Hypotrichosis associated with capillary malformation-arteriovenous malformation syndrome. ( 25059281 )
2014
41
A novel nonsense mutation in the CDSN gene underlying hypotrichosis simplex of the scalp in a Chinese family. ( 23746069 )
2014
42
A novel deletion mutation in the DSG4 gene underlies autosomal recessive hypotrichosis with variable phenotype in two unrelated consanguineous families. ( 25251037 )
2014
43
Marie-unna hereditary hypotrichosis. ( 25368478 )
2014
44
Application of bimatoprost ophthalmic solution 0.03% for the treatment of eyebrow hypotrichosis: series of ten cases. ( 24945645 )
2014
45
Mutations in the lipase-H gene causing autosomal recessive hypotrichosis and woolly hair. ( 24628704 )
2014
46
A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis. ( 25229783 )
2014
47
Long-Term Safety and Efficacy of Bimatoprost Solution 0.03% Application to the Eyelid Margin for the Treatment of Idiopathic and Chemotherapy-Induced Eyelash Hypotrichosis: A Randomised Controlled Trial. ( 25296533 )
2014
48
Hereditary hypotrichosis simplex of the scalp. ( 25484430 )
2014
49
Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome. ( 25168385 )
2014
50
A case of autosomal recessive woolly hair/hypotrichosis with alternation in severity: deterioration and improvement with age. ( 24474919 )
2013
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Variations for Hypotrichosis

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Expression for Hypotrichosis

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Search GEO for disease gene expression data for Hypotrichosis.
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Pathways for Hypotrichosis

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Pathways related to Hypotrichosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Developmental Biology 62
Show member pathways
 12.71 CDSN DSC3 DSG4 KRT25 KRT71 KRT74
2
Keratinization 62
Show member pathways
 11.62 CDSN DSC3 DSG4 KRT25 KRT71 KRT74
Sources

GO Terms for Hypotrichosis

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Cellular components related to Hypotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.43 KRT71 KRT74 KRT86
2 cornified envelope GO:0001533 9.33 CDSN DSC3 DSG4
3 intermediate filament GO:0005882 9.26 KRT25 KRT71 KRT74 KRT86
4 desmosome GO:0030057 8.8 CDSN DSC3 DSG4

Biological processes related to Hypotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 CDH3 DSC3 DSG4
2 single organismal cell-cell adhesion GO:0016337 9.58 CDH3 CDSN DSG4
3 keratinization GO:0031424 9.5 CDH3 DSC3 DSG4 KRT25 KRT71 KRT74
4 hair follicle morphogenesis GO:0031069 9.43 KRT25 KRT71
5 intermediate filament organization GO:0045109 9.37 KRT25 KRT71
6 hair follicle development GO:0001942 9.33 APCDD1 DSG4 SOX18
7 hair cycle GO:0042633 9.32 KRT25 SNRPE
8 hair cycle process GO:0022405 9.26 CDH3 SOX18
9 cornification GO:0070268 9.17 CDSN DSC3 DSG4 KRT25 KRT71 KRT74

Molecular functions related to Hypotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 KRT25 KRT71 KRT74 KRT86
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Sources for Hypotrichosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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