MCID: HYP048
MIFTS: 31

Hypotropia

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypotropia

MalaCards integrated aliases for Hypotropia:

Name: Hypotropia 12 72 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9841
ICD9CM 34 378.32
NCIt 46 C42086
SNOMED-CT 64 29491004
UMLS 69 C0152208

Summaries for Hypotropia

MalaCards based summary : Hypotropia is related to hypertropia and exotropia. An important gene associated with Hypotropia is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways are Neuroscience and Glioblastoma Multiforme. Affiliated tissues include eye, thyroid and testes, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 hypertropia 31.0 CHN1 KANTR KIF21A SAMHD1 TUBB3
2 exotropia 30.4 CHN1 KIF21A PHOX2A TUBB3
3 esotropia 30.3 CHN1 OPTN TUBB3
4 ptosis 30.2 KIF21A PHOX2A TUBB3
5 strabismus 29.7 CHN1 FRMD7 KIF21A PHOX2A TUBB3
6 brown syndrome 10.9
7 fibrosis of extraocular muscles, congenital, 2 10.5 KIF21A PHOX2A
8 marcus gunn phenomenon 10.4 CHN1 TUBB3
9 moebius syndrome 10.4 PHOX2A TUBB3
10 pathologic nystagmus 10.4 FRMD7 TUBB3
11 congenital ptosis 10.3 CHN1 KIF21A TUBB3
12 deafness, autosomal dominant 28 10.3 CHN1 KIF21A TUBB3
13 duane retraction syndrome 10.3 CHN1 KIF21A TUBB3
14 anisometropia 10.3 CHN1 OPTN
15 kearns-sayre syndrome 10.3 KIF21A PHOX2A TUBB3
16 alternating esotropia 10.3 CHN1 KANTR
17 dissociated nystagmus 10.3 FRMD7 KANTR
18 cerebellopontine angle meningioma 10.2 KANTR SAMHD1
19 oculomotor nerve paralysis 10.2 CHN1 KANTR
20 third cranial nerve disease 10.2 CHN1 KANTR
21 facial paralysis 10.2 KANTR TUBB3
22 amblyopia 10.2 CHN1 OPTN TUBB3
23 amyloid tumor 10.2 NF1 TUBB3
24 accommodative spasm 10.2 KANTR OPTN
25 scleral staphyloma 10.1 NF1 OPTN
26 congenital nystagmus 10.1 FRMD7 TUBB3
27 poland syndrome 10.1 CHN1 NF1 TUBB3
28 exposure keratitis 10.1 KANTR TUBB3
29 spinal canal and spinal cord meningioma 10.1 NF1 SAMHD1
30 purulent endophthalmitis 10.1 OPTN SAMHD1
31 spinal meningioma 10.1 NF1 SAMHD1
32 accommodative esotropia 10.1 CHN1 KANTR SAMHD1
33 hyperhidrosis, gustatory 10.1 KANTR NF1
34 myopia 10.0
35 thyroiditis 10.0
36 facial nerve disease 10.0 KANTR KIF21A PHOX2A TUBB3
37 cerebellopontine angle tumor 10.0 KANTR SAMHD1
38 nervous system disease 10.0 KANTR OPTN TUBB3
39 peripheral nervous system disease 10.0 CHN1 KANTR KIF21A TUBB3
40 ocular motility disease 10.0 CHN1 FRMD7 KIF21A PHOX2A TUBB3
41 internuclear ophthalmoplegia 9.9 KANTR NF1
42 tukel syndrome 9.9 APPL1 CHN1 KIF21A PHOX2A TUBB3
43 fibrosis of extraocular muscles, congenital, 1 9.8
44 entropion 9.8
45 optic nerve neoplasm 9.7 NF1 OPTN
46 cranial nerve disease 9.6 CHN1 FRMD7 KANTR KIF21A PHOX2A TUBB3
47 paralytic squint 9.5 CHN1 KANTR KIF21A PHOX2A SAMHD1 TUBB3

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 PDGFRB PHOX2A TPH1 AGT APPL1 CD200
2 cellular MP:0005384 10.02 APPL1 CD200 CHN1 GRB2 NF1 PDGFRB
3 homeostasis/metabolism MP:0005376 9.96 AGT APPL1 CD200 CHN1 GRB2 NF1
4 mortality/aging MP:0010768 9.85 AGT APPL1 CHN1 GRB2 NF1 OPTN
5 muscle MP:0005369 9.43 TPH1 AGT APPL1 CHN1 NF1 PDGFRB
6 skeleton MP:0005390 9.17 CD200 CHN1 FRMD7 GRB2 NF1 PDGFRB

Drugs & Therapeutics for Hypotropia

Search Clinical Trials , NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

MalaCards organs/tissues related to Hypotropia:

38
Eye, Thyroid, Testes

Publications for Hypotropia

Articles related to Hypotropia:

(show all 25)
# Title Authors Year
1
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. ( 28089746 )
2017
2
Exotropia and hypotropia as the initial presentation sign of thyroid eye disease in an 18-year-old man. ( 29288834 )
2017
3
To assess the efficacy of vertical muscle surgery for management of hypotropia in monocular elevation deficiency type II. ( 27699607 )
2016
4
Fixation-linked nondissociated hypotropia: a report of 3 cases. ( 25266837 )
2014
5
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. ( 25490238 )
2014
6
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. ( 23277737 )
2013
7
Managing a case of hypotropia with a positive traction test. ( 23343087 )
2013
8
Exotropia-hypotropia complex in high myopia. ( 24669372 )
2013
9
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. ( 21397798 )
2011
10
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). ( 22253487 )
2011
11
Acquired cyclic exotropia and hypotropia. ( 19541276 )
2009
12
Dissociated hypotropia: clinical features and surgical management of two cases. ( 17070470 )
2006
13
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. ( 12765542 )
2003
14
Fixation linked hypotropia in high myopia. A report of two similar cases. ( 12597767 )
2003
15
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. ( 11840359 )
2001
16
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. ( 11304822 )
2001
17
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. ( 10928671 )
2000
18
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. ( 10428589 )
1999
19
Postanesthetic hypotropia. ( 9610432 )
1998
20
Postanesthetic hypotropia: a unique syndrome in left eyes. ( 9423914 )
1997
21
Hypercorrection of hypotropia in Graves ophthalmopathy. ( 8433813 )
1993
22
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. ( 1565447 )
1992
23
Primary-position hypotropia after anterior transposition of the inferior oblique. ( 3947298 )
1986
24
Management of ipsilateral ptosis with hypotropia. ( 3096370 )
1986
25
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. ( 5362882 )
1969

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 AGT NF1 OPTN TPH1 TUBB3
2 11.38 GRB2 NF1 PDGFRB
3 11.08 GRB2 PDGFRB TUBB3

GO Terms for Hypotropia

Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 APPL1 GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.43 AGT GRB2 PDGFRB
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 AGT NF1
3 sympathetic nervous system development GO:0048485 8.96 NF1 PHOX2A
4 positive regulation of reactive oxygen species metabolic process GO:2000379 8.8 AGT GRB2 PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 GRB2

Sources for Hypotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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