MCID: HYP048
MIFTS: 30

Hypotropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypotropia

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Aliases & Descriptions for Hypotropia:

Name: Hypotropia 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:9841
ICD9CM30 378.32
SNOMED-CT60 29491004
NCIt43 C42086

Summaries for Hypotropia

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Wikipedia:69 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypotropia is related to meckel syndrome 3 and hypotropia. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways are G-protein signaling_H-RAS regulation pathway and Signaling events mediated by TCPTP. Affiliated tissues include eye, testes and thyroid, and related mouse phenotypes are muscle and cellular.

Related Diseases for Hypotropia

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Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to hypotropia

Symptoms for Hypotropia

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Drugs & Therapeutics for Hypotropia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

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Anatomical Context for Hypotropia

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MalaCards organs/tissues related to Hypotropia:

34
Eye, Testes, Thyroid

Animal Models for Hypotropia or affiliated genes

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MGI Mouse Phenotypes related to Hypotropia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7AGT, APPL1, CHN1, NF1, PDGFRB, TPH1
2MP:00053846.9APPL1, CHN1, GRB2, NF1, PDGFRB, PHOX2A
3MP:00036316.8AGT, CHN1, GRB2, NF1, PDGFRB, PHOX2A
4MP:00053866.5AGT, APPL1, CHN1, GRB2, NF1, PHOX2A
5MP:00107686.3AGT, APPL1, GRB2, NF1, PDGFRB, PHOX2A
6MP:00053766.3AGT, APPL1, CHN1, GRB2, NF1, PDGFRB
7MP:00053786.2AGT, APPL1, CHN1, GRB2, NF1, PDGFRB

Publications for Hypotropia

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Articles related to Hypotropia:

(show all 22)
idTitleAuthorsYear
1
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. (25490238)
2014
2
Fixation-linked nondissociated hypotropia: a report of 3 cases. (25266837)
2014
3
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. (23277737)
2013
4
Exotropia-hypotropia complex in high myopia. (24669372)
2013
5
Managing a case of hypotropia with a positive traction test. (23343087)
2013
6
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). (22253487)
2011
7
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. (21397798)
2011
8
Acquired cyclic exotropia and hypotropia. (19541276)
2009
9
Dissociated hypotropia: clinical features and surgical management of two cases. (17070470)
2006
10
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. (12765542)
2003
11
Fixation linked hypotropia in high myopia. A report of two similar cases. (12597767)
2003
12
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. (11304822)
2001
13
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. (11840359)
2001
14
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. (10928671)
2000
15
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. (10428589)
1999
16
Postanesthetic hypotropia. (9610432)
1998
17
Postanesthetic hypotropia: a unique syndrome in left eyes. (9423914)
1997
18
Hypercorrection of hypotropia in Graves ophthalmopathy. (8433813)
1993
19
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. (1565447)
1992
20
Management of ipsilateral ptosis with hypotropia. (3096370)
1986
21
Primary-position hypotropia after anterior transposition of the inferior oblique. (3947298)
1986
22
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. (5362882)
1969

Variations for Hypotropia

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Expression for genes affiliated with Hypotropia

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Search GEO for disease gene expression data for Hypotropia.

Pathways for genes affiliated with Hypotropia

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GO Terms for genes affiliated with Hypotropia

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Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicle membraneGO:00125069.5APPL1, GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:00484859.9NF1, PHOX2A
2positive regulation of reactive oxygen species metabolic processGO:20003799.3AGT, GRB2, PDGFRB
3regulation of long-term neuronal synaptic plasticityGO:00481699.0AGT, NF1
4positive regulation of GTPase activityGO:00435478.0CHN1, GRB2, NF1, PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ephrin receptor bindingGO:00468759.7CHN1, GRB2

Sources for Hypotropia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet