MCID: HYP048
MIFTS: 30

Hypotropia malady

Neuronal diseases, Eye diseases categories

Aliases & Classifications for Hypotropia

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Aliases & Descriptions for Hypotropia:

Name: Hypotropia 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:9841
ICD9CM29 378.32
SNOMED-CT59 29491004
NCIt42 C42086

Summaries for Hypotropia

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Wikipedia:68 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypotropia is related to fibrosis of extraocular muscles, congenital, 2 and ptosis, congenital. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways are a6b1 and a6b4 Integrin signaling and pilocytic astrocytoma. Affiliated tissues include eye, testes and thyroid, and related mouse phenotypes are craniofacial and muscle.

Related Diseases for Hypotropia

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Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to hypotropia

Symptoms for Hypotropia

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Drugs & Therapeutics for Hypotropia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

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Anatomical Context for Hypotropia

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MalaCards organs/tissues related to Hypotropia:

33
Eye, Testes, Thyroid

Animal Models for Hypotropia or affiliated genes

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MGI Mouse Phenotypes related to Hypotropia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.0GRB2, MET, NF1, PDGFRB, SOX3
2MP:00053697.3AGT, APPL1, CHN1, MET, NF1, PDGFRB
3MP:00053857.0AGT, APPL1, GRB2, MET, NF1, PDGFRB
4MP:00053867.0AGT, CHN1, GRB2, MET, NF1, PHOX2A
5MP:00053846.7APPL1, CHN1, GRB2, MET, NF1, PDGFRB
6MP:00053786.5AGT, CHN1, GRB2, MET, NF1, PDGFRB
7MP:00036316.4AGT, CHN1, GRB2, MET, NF1, PDGFRB
8MP:00053765.8AGT, APPL1, GRB2, MET, NF1, PDGFRB

Publications for Hypotropia

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Articles related to Hypotropia:

(show all 22)
idTitleAuthorsYear
1
Fixation-linked nondissociated hypotropia: a report of 3 cases. (25266837)
2014
2
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. (25490238)
2014
3
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. (23277737)
2013
4
Managing a case of hypotropia with a positive traction test. (23343087)
2013
5
Exotropia-hypotropia complex in high myopia. (24669372)
2013
6
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. (21397798)
2011
7
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). (22253487)
2011
8
Acquired cyclic exotropia and hypotropia. (19541276)
2009
9
Dissociated hypotropia: clinical features and surgical management of two cases. (17070470)
2006
10
Fixation linked hypotropia in high myopia. A report of two similar cases. (12597767)
2003
11
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. (12765542)
2003
12
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. (11304822)
2001
13
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. (11840359)
2001
14
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. (10928671)
2000
15
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. (10428589)
1999
16
Postanesthetic hypotropia. (9610432)
1998
17
Postanesthetic hypotropia: a unique syndrome in left eyes. (9423914)
1997
18
Hypercorrection of hypotropia in Graves ophthalmopathy. (8433813)
1993
19
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. (1565447)
1992
20
Management of ipsilateral ptosis with hypotropia. (3096370)
1986
21
Primary-position hypotropia after anterior transposition of the inferior oblique. (3947298)
1986
22
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. (5362882)
1969

Variations for Hypotropia

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Expression for genes affiliated with Hypotropia

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Search GEO for disease gene expression data for Hypotropia.

Pathways for genes affiliated with Hypotropia

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GO Terms for genes affiliated with Hypotropia

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Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicle membraneGO:00125069.5APPL1, GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:00484859.9NF1, PHOX2A
2regulation of long-term neuronal synaptic plasticityGO:00481699.8AGT, NF1
3smooth muscle tissue developmentGO:00487459.6NF1, PDGFRB
4adrenal gland developmentGO:00303259.4NF1, PDGFRB
5positive regulation of reactive oxygen species metabolic processGO:20003799.0AGT, GRB2, PDGFRB
6insulin receptor signaling pathwayGO:00082868.2APPL1, GRB2, NF1, PDGFRB
7axon guidanceGO:00074117.7GRB2, MET, NF1, PDGFRB, TUBB3

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ephrin receptor bindingGO:00468759.7CHN1, GRB2

Sources for Hypotropia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet