MCID: HYP048
MIFTS: 27

Hypotropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypotropia

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Aliases & Descriptions for Hypotropia:

Name: Hypotropia 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:9841
ICD9CM32 378.32
SNOMED-CT62 29491004
NCIt45 C42086

Summaries for Hypotropia

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Wikipedia:71 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypotropia is related to hypertropia and neurodegeneration due to cerebral folate transport deficiency. An important gene associated with Hypotropia is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways is Glioblastoma Multiforme. Affiliated tissues include eye, testes and thyroid, and related mouse phenotypes are muscle and growth/size/body region.

Related Diseases for Hypotropia

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Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to hypotropia

Symptoms & Phenotypes for Hypotropia

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MGI Mouse Phenotypes related to Hypotropia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9AGT, APPL1, CHN1, NF1, PDGFRB, TPH1
2MP:00053787.5AGT, APPL1, CHN1, GRB2, NF1, PDGFRB
3MP:00107687.2AGT, APPL1, CHN1, GRB2, NF1, PDGFRB
4MP:00036317.1AGT, CD200, CHN1, GRB2, NF1, PDGFRB
5MP:00053846.9APPL1, CD200, CHN1, GRB2, NF1, PDGFRB
6MP:00053866.7AGT, APPL1, CD200, CHN1, GRB2, NF1
7MP:00053766.7AGT, APPL1, CD200, CHN1, GRB2, NF1
8MP:00053906.7CD200, CHN1, FRMD7, GRB2, NF1, PDGFRB

Drugs & Therapeutics for Hypotropia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

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Anatomical Context for Hypotropia

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MalaCards organs/tissues related to Hypotropia:

36
Eye, Testes, Thyroid

Publications for Hypotropia

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Articles related to Hypotropia:

(show all 24)
idTitleAuthorsYear
1
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. (28089746)
2017
2
To assess the efficacy of vertical muscle surgery for management of hypotropia in monocular elevation deficiency type II. (27699607)
2016
3
Fixation-linked nondissociated hypotropia: a report of 3 cases. (25266837)
2014
4
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. (25490238)
2014
5
Exotropia-hypotropia complex in high myopia. (24669372)
2013
6
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. (23277737)
2013
7
Managing a case of hypotropia with a positive traction test. (23343087)
2013
8
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. (21397798)
2011
9
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). (22253487)
2011
10
Acquired cyclic exotropia and hypotropia. (19541276)
2009
11
Dissociated hypotropia: clinical features and surgical management of two cases. (17070470)
2006
12
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. (12765542)
2003
13
Fixation linked hypotropia in high myopia. A report of two similar cases. (12597767)
2003
14
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. (11304822)
2001
15
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. (11840359)
2001
16
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. (10928671)
2000
17
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. (10428589)
1999
18
Postanesthetic hypotropia. (9610432)
1998
19
Postanesthetic hypotropia: a unique syndrome in left eyes. (9423914)
1997
20
Hypercorrection of hypotropia in Graves ophthalmopathy. (8433813)
1993
21
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. (1565447)
1992
22
Management of ipsilateral ptosis with hypotropia. (3096370)
1986
23
Primary-position hypotropia after anterior transposition of the inferior oblique. (3947298)
1986
24
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. (5362882)
1969

Variations for Hypotropia

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Expression for genes affiliated with Hypotropia

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Search GEO for disease gene expression data for Hypotropia.

Pathways for genes affiliated with Hypotropia

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Pathways related to Hypotropia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.0GRB2, NF1, PDGFRB

GO Terms for genes affiliated with Hypotropia

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Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicle membraneGO:00125069.6APPL1, GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of long-term neuronal synaptic plasticityGO:00481699.8AGT, NF1
2sympathetic nervous system developmentGO:00484859.7NF1, PHOX2A
3agingGO:00075689.6AGT, GRB2, PDGFRB
4positive regulation of reactive oxygen species metabolic processGO:20003799.5AGT, GRB2, PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ephrin receptor bindingGO:00468759.7CHN1, GRB2

Sources for Hypotropia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet