MCID: HYP048
MIFTS: 31

Hypotropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypotropia

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Aliases & Descriptions for Hypotropia:

Name: Hypotropia 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:9841
ICD9CM29 378.32
SNOMED-CT59 29491004
NCIt42 C42086
UMLS65 C0152208

Summaries for Hypotropia

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Wikipedia:68 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards based summary: Hypotropia is related to autism susceptibility 17 and hypertropia. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways are G-protein signaling_H-RAS regulation pathway and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include eye, breast and bone, and related mouse phenotypes are renal/urinary system and muscle.

Related Diseases for Hypotropia

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Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1autism susceptibility 1710.4KIF21A, PHOX2A
2hypertropia10.4
3meckel syndrome 310.3CHN1, KIF21A
4cyclotropia10.3CHN1, KIF21A
5breast-ovarian cancer, familial, 210.2CHN1, TUBB3
6brain injury10.2
7traumatic brain injury10.2
8generalized dystonia10.2
9achondrogenesis10.2
10gastroparesis10.2
11hemolytic-uremic syndrome10.2
12interstitial cystitis10.2
13chronic interstitial cystitis10.2
14cystitis10.2
15post-thrombotic syndrome10.2
16poliomyelitis10.2
17dystonia10.2
18muscular dystrophy10.2
19endotheliitis10.2
20endometriosis in scar of skin10.2CHN1, KIF21A, PHOX2A
21sensorineural hearing loss10.2KIF21A, PHOX2A, TUBB3
22hallucinogen abuse10.0CHN1, FRMD7, KIF21A, PHOX2A
23partial third-nerve palsy10.0CHN1, KIF21A, PHOX2A, TUBB3
24ametropic amblyopia10.0CHN1, KIF21A, PHOX2A, TUBB3
25lipid-rich carcinoma10.0CHN1, FRMD7, KIF21A, PHOX2A
26signet ring cell variant cervical mucinous adenocarcinoma10.0AGT, TPH1
27chest wall lymphoma10.0NF1, TUBB3
28atypical polypoid adenomyoma9.9NF1, SOX3
29chronic tympanitis9.9APPL1, TUBB3
30subclavian artery aneurysm9.9NF1, SOX3
31water-clear cell adenoma9.8CHN1, FRMD7, KIF21A, PHOX2A, TUBB3
32hypothyroidism due to deficient transcription factors involved in pituitary development or function9.7NF1, PDGFRB
33cauda equina intradural extramedullary astrocytoma9.7NF1, PDGFRB
34total circumpapillary dystrophy of choroid7.3AGT, APPL1, CHN1, FRMD7, GRB2, KIF21A

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to hypotropia

Symptoms for Hypotropia

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Drugs & Therapeutics for Hypotropia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

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Anatomical Context for Hypotropia

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MalaCards organs/tissues related to Hypotropia:

33
Eye, Breast, Bone, Thyroid, Ovary, Endothelial, Monocytes

Animal Models for Hypotropia or affiliated genes

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MGI Mouse Phenotypes related to Hypotropia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.6AGT, GRB2, NF1, PDGFRB, TLR7
2MP:00053697.3AGT, APPL1, CHN1, NF1, PDGFRB, TPH1
3MP:00036317.1AGT, CHN1, GRB2, NF1, PDGFRB, PHOX2A
4MP:00053786.9AGT, CHN1, GRB2, NF1, PDGFRB, PHOX2A
5MP:00053846.5APPL1, CHN1, GRB2, NF1, PDGFRB, PHOX2A
6MP:00053765.8AGT, APPL1, CHN1, GRB2, NF1, PDGFRB

Publications for Hypotropia

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Articles related to Hypotropia:

(show all 22)
idTitleAuthorsYear
1
A Case Report: Pseudoangiomatous Stromal Hyperplasia Tumor Presenting as a Palpable Mass. (26835457)
2015
2
miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPI+ expression. (25258381)
2014
3
Carbonic anhydrase IX expression is associated with favorable prognostic factors in small intestinal carcinoma. (24217923)
2014
4
Severe osteoporosis and mutation in NOTCH2 gene in a woman with Hajdu-Cheney syndrome. (23117206)
2013
5
An interstitial, apparently-balanced chromosomal insertion in the etiology of Langer-Giedion syndrome in an Asian family. (23832104)
2013
6
Recurrence patterns of oral leukoplakia after curative surgical resection: important factors that predict the risk of recurrence and malignancy. (22697318)
2012
7
Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians. (22539603)
2012
8
Lekti immunochemistry for the diagnosis of netherton syndrome. (22534635)
2012
9
Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. (20978098)
2011
10
Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome. (21225123)
2010
11
Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration. (20173307)
2010
12
Onchocerciasis Control: Vision for the Future from a Ghanian perspective. (19154624)
2009
13
Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in follicular adenoma of thyroid gland. (19679966)
2009
14
Cryptic genomic abnormalities associated with coexpression of KOR-SA3544 and NG.2 in proB acute lymphoblastic leukemia. (18767415)
2007
15
Lumbar disc herniation in adolescence. (17337916)
2007
16
Hyper-activated IRF-1 and STAT1 contribute to enhanced interferon stimulated gene (ISG) expression by interferon alpha and gamma co-treatment in human hepatoma cells. (16987558)
2006
17
Polymorphisms of the DNA mismatch repair gene HMSH2 in breast cancer occurence and progression. (16252083)
2005
18
High prevalence and increasing incidence of Addison's disease in western Norway. (12072049)
2002
19
Effects of gonadotropin-releasing hormone agonist on steroidogenesis in the rat ovary. (8088692)
1994
20
Isolated unilateral pulmonary artery agenesis. (8469014)
1993
21
Enzymatic defect in 'X-linked' sideroblastic anemia: molecular evidence for erythroid delta-aminolevulinate synthase deficiency. (1570328)
1992
22
Generation of anencephaly: 1. Aberrant neurulation and 2. Conversion of exencephaly to anencephaly. (6502191)
1984

Variations for Hypotropia

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Expression for genes affiliated with Hypotropia

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Search GEO for disease gene expression data for Hypotropia.

Pathways for genes affiliated with Hypotropia

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GO Terms for genes affiliated with Hypotropia

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Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:00165259.4AGT, NF1
2regulation of MAPK cascadeGO:00434089.2GRB2, NF1
3positive regulation of reactive oxygen species metabolic processGO:20003799.2AGT, GRB2, PDGFRB
4activation of MAPKK activityGO:00001868.7GRB2, NF1, PDGFRB
5MAPK cascadeGO:00001658.4GRB2, NF1, PDGFRB

Sources for Hypotropia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet