MCID: HYP048
MIFTS: 22

Hypotropia malady

Summaries for Hypotropia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

MalaCards: Hypotropia is related to hypertropia and strabismus. An important gene associated with Hypotropia is PHOX2A (paired-like homeobox 2a), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q. The compounds tripeptide and acth have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotypes are growth/size and no phenotypic analysis.

Aliases & Classifications for Hypotropia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

hypotropia 8 10 61


External Ids:

Disease Ontology8 DOID:9841
NCIt40 C42086
SNOMED-CT57 29491004
ICD9CM27 378.32

Related Diseases for Hypotropia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hypotropia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1hypertropia10.0
2strabismus10.0
3exotropia10.0PHOX2A

Clinical Features for Hypotropia

Drugs & Therapeutics for Hypotropia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypotropia

Drug clinical trials:

Search ClinicalTrials for Hypotropia

Search NIH Clinical Center for Hypotropia

Search CenterWatch for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypotropia:

33
Thyroid

Animal Models for Hypotropia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hypotropia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.5MC1R, OXTR, PHOX2A
2MP:00030128.4MC1R, OXTR, PHOX2A
3MP:00053868.2MC1R, OXTR, PHOX2A

Publications for Hypotropia

Sources:
51PubMed
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Articles related to Hypotropia:

(show all 19)
idTitleAuthorsYear
1
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. (23277737)
2013
2
Managing a case of hypotropia with a positive traction test. (23343087)
2013
3
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. (21397798)
2011
4
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). (22253487)
2011
5
Acquired cyclic exotropia and hypotropia. (19541276)
2009
6
Dissociated hypotropia: clinical features and surgical management of two cases. (17070470)
2006
7
Fixation linked hypotropia in high myopia. A report of two similar cases. (12597767)
2003
8
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. (12765542)
2003
9
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. (11304822)
2001
10
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. (11840359)
2001
11
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. (10928671)
2000
12
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. (10428589)
1999
13
Postanesthetic hypotropia. (9610432)
1998
14
Postanesthetic hypotropia: a unique syndrome in left eyes. (9423914)
1997
15
Hypercorrection of hypotropia in Graves ophthalmopathy. (8433813)
1993
16
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. (1565447)
1992
17
Management of ipsilateral ptosis with hypotropia. (3096370)
1986
18
Primary-position hypotropia after anterior transposition of the inferior oblique. (3947298)
1986
19
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. (5362882)
1969

Genetic Variations for Hypotropia

Expression for genes affiliated with Hypotropia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for genes affiliated with Hypotropia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
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Pathways related to Hypotropia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1MC1R, OXTR
2
Hide members
9.1MC1R, OXTR

Compounds for genes affiliated with Hypotropia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Hypotropia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tripeptide459.2MC1R, OXTR
2acth459.1MC1R, OXTR
3adenylate459.1MC1R, OXTR
4forskolin45 50 1111.0OXTR, MC1R
5dopamine45 29 11 2412.0OXTR, PHOX2A

GO Terms for genes affiliated with Hypotropia

Products for genes affiliated with Hypotropia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hypotropia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet