MCID: HYP048
MIFTS: 27

Hypotropia malady

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Hypotropia

Aliases & Descriptions for Hypotropia:

Name: Hypotropia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9841
ICD9CM 35 378.32
NCIt 47 C42086
SNOMED-CT 64 29491004
UMLS 69 C0152208

Summaries for Hypotropia

MalaCards based summary : Hypotropia is related to hypertropia and neurodegeneration due to cerebral folate transport deficiency. An important gene associated with Hypotropia is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is Glioblastoma Multiforme. Affiliated tissues include eye, testes and thyroid, and related phenotypes are behavior/neurological and cellular

Wikipedia : 71 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 hypertropia 10.8
2 neurodegeneration due to cerebral folate transport deficiency 10.2 KIF21A PHOX2A
3 tubulointerstitial nephritis with uveitis 10.2 CHN1 TUBB3
4 fanconi anemia, complementation group d1 10.2 PHOX2A TUBB3
5 febrile seizures, familial, 1 10.2 CHN1 KIF21A TUBB3
6 endometriosis of ovary 10.1 CHN1 KIF21A PHOX2A
7 interstitial keratitis 10.1 CHN1 SAMHD1
8 amyotrophic neuralgia 10.1 CHN1 PHOX2A TUBB3
9 ulceration of vulva 10.1 CHN1 KIF21A TUBB3
10 mental retardation with spastic paraplegia 10.1 KIF21A PHOX2A TUBB3
11 deep keratitis 10.1 CHN1 SAMHD1
12 joubert syndrome 6 10.1 CHN1 KIF21A
13 pontocerebellar hypoplasia 10.1 CHN1 KIF21A PHOX2A TUBB3
14 oliver syndrome 10.0 CHN1 NF1 TUBB3
15 lingual-facial-buccal dyskinesia 10.0 CHN1 KIF21A SAMHD1 TUBB3
16 nerve fibre bundle defect 10.0 CHN1 FRMD7 KIF21A PHOX2A
17 chronic lacrimal gland enlargement 10.0 CHN1 FRMD7 KIF21A PHOX2A TUBB3
18 urinary bladder villous adenoma 10.0 CHN1 FRMD7 KIF21A PHOX2A TUBB3
19 total third-nerve palsy 9.9 CHN1 KIF21A PHOX2A SAMHD1 TUBB3
20 childhood vagina botryoid rhabdomyosarcoma 9.9 NF1 TUBB3
21 mental retardation, autosomal dominant 7 9.9 APPL1 CHN1 KIF21A PHOX2A TUBB3
22 exotropia 9.9
23 myopia 9.9
24 esotropia 9.9
25 ptosis 9.7
26 entropion 9.7
27 strabismus 9.7
28 eye disease 9.7
29 thyroiditis 9.7
30 alopecia areata 8.3 AGT APPL1 CD200 CHN1 FRMD7 GRB2

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 CD200 CHN1 GRB2 NF1 PDGFRB PHOX2A
2 cellular MP:0005384 10.1 APPL1 CD200 CHN1 GRB2 NF1 PDGFRB
3 growth/size/body region MP:0005378 10.02 PHOX2A SOX3 TPH1 AGT APPL1 CHN1
4 homeostasis/metabolism MP:0005376 10.02 AGT APPL1 CD200 CHN1 GRB2 NF1
5 mortality/aging MP:0010768 9.96 AGT APPL1 CHN1 GRB2 NF1 PDGFRB
6 muscle MP:0005369 9.63 AGT APPL1 CHN1 NF1 PDGFRB TPH1
7 nervous system MP:0003631 9.61 GRB2 NF1 PDGFRB PHOX2A SOX3 TUBB3
8 skeleton MP:0005390 9.23 CD200 CHN1 FRMD7 GRB2 NF1 PDGFRB

Drugs & Therapeutics for Hypotropia

Search Clinical Trials , NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

MalaCards organs/tissues related to Hypotropia:

39
Eye, Testes, Thyroid

Publications for Hypotropia

Articles related to Hypotropia:

(show all 24)
id Title Authors Year
1
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. ( 28089746 )
2017
2
To assess the efficacy of vertical muscle surgery for management of hypotropia in monocular elevation deficiency type II. ( 27699607 )
2016
3
Fixation-linked nondissociated hypotropia: a report of 3 cases. ( 25266837 )
2014
4
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. ( 25490238 )
2014
5
Exotropia-hypotropia complex in high myopia. ( 24669372 )
2013
6
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. ( 23277737 )
2013
7
Managing a case of hypotropia with a positive traction test. ( 23343087 )
2013
8
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. ( 21397798 )
2011
9
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). ( 22253487 )
2011
10
Acquired cyclic exotropia and hypotropia. ( 19541276 )
2009
11
Dissociated hypotropia: clinical features and surgical management of two cases. ( 17070470 )
2006
12
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. ( 12765542 )
2003
13
Fixation linked hypotropia in high myopia. A report of two similar cases. ( 12597767 )
2003
14
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. ( 11304822 )
2001
15
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. ( 11840359 )
2001
16
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. ( 10928671 )
2000
17
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. ( 10428589 )
1999
18
Postanesthetic hypotropia. ( 9610432 )
1998
19
Postanesthetic hypotropia: a unique syndrome in left eyes. ( 9423914 )
1997
20
Hypercorrection of hypotropia in Graves ophthalmopathy. ( 8433813 )
1993
21
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. ( 1565447 )
1992
22
Management of ipsilateral ptosis with hypotropia. ( 3096370 )
1986
23
Primary-position hypotropia after anterior transposition of the inferior oblique. ( 3947298 )
1986
24
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. ( 5362882 )
1969

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 GRB2 NF1 PDGFRB

GO Terms for Hypotropia

Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 APPL1 GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.43 AGT GRB2 PDGFRB
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 AGT NF1
3 sympathetic nervous system development GO:0048485 8.96 NF1 PHOX2A
4 positive regulation of reactive oxygen species metabolic process GO:2000379 8.8 AGT GRB2 PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 GRB2

Sources for Hypotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....