MCID: HYP266
MIFTS: 60

Hypoxia malady

Summaries for Hypoxia

Sources:
44NINDS, 46Novus Biologicals, 33MalaCards
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Novus Biologicals:46 Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to a lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1 alpha and HIF-1 beta. HIF-1 alpha accumulates under hypoxic conditions whereas HIF-1 beta is constitutively expressed. HIF-1 alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regulation of a number of factors important for solid tumor expansion including the angiogenic factor VEGF.

MalaCards: Hypoxia is related to adenocarcinoma and renal clear cell carcinoma. An important gene associated with Hypoxia is EGLN2 (egl-9 family hypoxia-inducible factor 2), and among its related pathways are Cellular response to hypoxia and Development HGF signaling pathway. The compounds oxygen and proline have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

NINDS:44 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

Aliases & Classifications for Hypoxia

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

hypoxia 44 61


Related Diseases for Hypoxia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hypoxia:



Diseases related to hypoxia

Clinical Features for Hypoxia

Drugs & Therapeutics for Hypoxia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hypoxia

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Genetic Tests for Hypoxia

Anatomical Context for Hypoxia

Sources:
33MalaCards
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MalaCards organs/tissues related to Hypoxia:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Cortex, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Breast, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Prefrontal cortex, Amygdala, Cardiac myocytes, Atrioventricular node, Fetal liver, Fetal lung, Bronchial epithelium, Fetal thyroid, Pancreatic islet, Pituitary, Testis leydig

Animal Models for Hypoxia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hypoxia

Sources:
51PubMed
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Articles related to Hypoxia:

(show top 50)    (show all 5411)
idTitleAuthorsYear
1
The integrin-linked kinase gene up-regulated by hypoxia plays its pro-survival role in colorectal cancer cells. (24299190)
2014
2
Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. (24347249)
2013
3
The critical role of mast cell-derived hypoxia-inducible factor-1I+ in human and mice melanoma growth. (23161568)
2013
4
Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia. (24170091)
2013
5
Interlinking of Hypoxia and Estrogen in Thyroid Cancer Progression. (24304276)
2013
6
Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. (24358213)
2013
7
Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible. (24150242)
2013
8
Skin mild hypoxia enhances killing of UVB-damaged keratinocytes through reactive oxygen species-mediated apoptosis requiring Noxa and Bim. (22245094)
2012
9
Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. (22911847)
2012
10
Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/ fasting-induced adipose factor) by human adipocytes. (21709421)
2011
11
The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. (19955572)
2010
12
Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. (20567615)
2010
13
The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events. (20626887)
2010
14
Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts. (21034500)
2010
15
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. (20961996)
2010
16
Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia-ischemia. (19254588)
2009
17
Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. (19187784)
2009
18
Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses. (19321184)
2009
19
Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. (19010893)
2008
20
Influence of HSP70 on function and energy metabolism of mitochondria in intestinal epithelial cells after hypoxia/reoxygenation]. (18982566)
2008
21
TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis. (18823375)
2008
22
Hypoxia-generated superoxide induces the development of the adhesion phenotype. (18538674)
2008
23
Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. (17609290)
2007
24
Inhibition of hypoxia-induced angiogenesis by sodium butyrate, a histone deacetylase inhibitor, through hypoxia-inducible factor-1alpha suppression. (17342317)
2007
25
Regulatory role of hypoxia inducible factor-1 alpha in the changes of contraction of vascular smooth muscle cell induced by hypoxia]. (17996129)
2007
26
Hypoxia and the HIF system in kidney disease. (18026918)
2007
27
Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. (17525262)
2007
28
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. (17045587)
2007
29
2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis. (16883594)
2006
30
A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. (15572379)
2005
31
Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. (15569687)
2005
32
Hypoxia and HIF-1alpha in osteoarthritis. (15611874)
2005
33
Clinical studies of hypoxia modification in radiotherapy. (15254866)
2004
34
Influence of mechanical stretch on the expression of myosin heavy chain mRNA in cardiomyocyte subjected to ischemia and hypoxia]. (15308061)
2004
35
Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: role of Bcl-2, Bcl-xL and Bax in tubular injury. (15375594)
2004
36
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
37
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. (12657718)
2003
38
Expression of P53, P21 in human lung adenocarcinoma A549 cell strains under hypoxia conditions and the effect of TSA on their expression. (15015635)
2003
39
Neuronal apoptosis in the dentate gyrus in humans with subarachnoid hemorrhage and cerebral hypoxia. (12146801)
2002
40
Erythroid carbonic anhydrase and hsp70 expression in chick embryonic development: role of cAMP and hypoxia. (11171668)
2001
41
Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets. (11385146)
2001
42
Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia. (10634417)
2000
43
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. (10582706)
1999
44
von Hippel-Lindau protein induces hypoxia-regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells. (10514498)
1999
45
Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing. (9660756)
1998
46
Are elevated cerebrospinal fluid levels of IL-6 in sudden unexplained deaths, infectious deaths and deaths due to heart/lung disease in infants and children due to hypoxia? (9736227)
1998
47
Cerebral hypoxia after hyperventilation causes "re-build-up" phenomenon and TIA in childhood moyamoya disease. A near-infrared spectroscopy study. (8891362)
1996
48
Chronic hypoxia in neuronal cell culture: metabolic consequences. (2169712)
1990
49
Taurine improves the recovery of neuronal function following cerebral hypoxia: an in vitro study. (3586851)
1987
50
Electroencephalographic aspects of acute and chronic cerebral hypoxia in cerebral circulatory insufficiency. (4167787)
1967

Genetic Variations for Hypoxia

Expression for genes affiliated with Hypoxia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoxia

Search GEO for disease gene expression data for Hypoxia.

Pathways for genes affiliated with Hypoxia

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
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Pathways related to Hypoxia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
12.6EPAS1, CA9, ARNT, EGLN2, EGLN1, EGLN3
2
Hide members
12.2ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
312.2ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
411.9ARNT, EGLN2, EGLN1, EGLN3, HIF1AN, EP300
511.9CA9, CA12, ARNT, EGLN1, HIF1A, HIF1AN
611.7ARNT, EGLN2, EGLN1, HIF1A, HIF1AN, EP300
711.7ARNT, EGLN2, EGLN1, EGLN3, HIF1A, EP300
811.7CA9, ARNT, EGLN1, HIF1A, HIF1AN, EP300
911.7CA9, ARNT, EGLN1, EGLN3, HIF1A, EP300
1011.3ARNT, HIF1A, HIF3A, HIF1AN
1111.1EPAS1, HIF1AN, HIF1A
12
Hide members
11.1EPAS1, HIF1A, ARNT
13
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
11.1ARNT, HIF1A, EP300
1411.1EP300, HIF1A, ARNT
15
Hide members
11.1CA2, CA4, CA9
16
Hide members
10.9CA4, CA2

Compounds for genes affiliated with Hypoxia

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Hypoxia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1oxygen45 2414.4HYOU1, CA2, CA9, ARNT, ARNT2, EGLN2
2proline4512.8CA2, CA9, EGLN2, EGLN1, EGLN3, P4HTM
3vegf4512.8CA9, ARNT, EGLN2, EGLN1, EGLN3, HIF1A
4zinc45 2413.3CA2, CA4, CA9, CA12, ARNT, EGLN1
5tyrosine4511.9HYOU1, EPAS1, EP300, HIF1A, ARNT, CA9
6alpha-ketoglutarate4511.9EGLN2, EGLN1, EGLN3, HIF1A, HIF1AN
7carbon dioxide45 2412.9CA2, CA4, CA9, CA12, HIF1AN
8ascorbic acid45 2412.8HIF1A, P4HTM, EGLN3, EGLN1, EGLN2
9u 1046011.7CA2, CA4, CA9, CA12
10Benzthiazide1111.7CA2, CA4, CA9, CA12
11Hydroflumethiazide1111.7CA2, CA4, CA9, CA12
12iron45 2412.7ARNT, EGLN2, HIF1A, HIF1AN, EPAS1
13vitamin c50 1112.7EGLN2, EGLN1, EGLN3, P4HTM
14ellagic acid45 60 1113.7CA12, CA9, CA4, CA2
15L-Proline11 2412.7EGLN2, EGLN1, EGLN3, P4HTM
16hydrochlorothiazide45 50 29 11 2415.7CA2, CA4, CA9, CA12
17zonisamide45 1112.7CA2, CA4, CA9, CA12
18cobalt45 2412.7CA2, ARNT, HIF1A, HIF1AN
19hydroxyproline45 11 2413.7EGLN2, EGLN1, EGLN3, P4HTM
20bicarbonate4511.6CA2, CA4, CA9, CA12
21glucose4511.6CA9, ARNT, HIF1A, EP300, EPAS1, HYOU1
22asparagine4511.6EGLN1, HIF1A, HIF1AN, EP300
23dorzolamide45 1112.5CA2, CA4, CA9
24brinzolamide45 1112.5CA2, CA4, CA9
25dichlorphenamide45 1112.5CA2, CA4, CA9
26ethoxzolamide45 1112.5CA9, CA4, CA2
27methazolamide45 1112.5CA9, CA4, CA2
28acetazolamide45 1112.4CA9, CA4, CA2
29sodium bicarbonate45 1112.4CA9, CA4, CA2
30sulfonamide4511.4CA2, CA4, CA9
31N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE1111.2HIF1A, EGLN1
32Methyclothiazide1111.1CA2, CA4
33chlorothiazide29 1112.1CA4, CA2
34Trichlormethiazide1111.1CA4, CA2
35bendroflumethiazide45 1112.0CA4, CA2
36pimonidazole4511.0HIF1A, CA9
37cocl24511.0ARNT, HIF1A
38estrogen4510.9CA2
39cyclothiazide29 45 1112.9CA4, CA2
40topiramate45 11 2412.6CA2, CA4

GO Terms for genes affiliated with Hypoxia

Sources:
16Gene Ontology
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Cellular components related to Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565411.9EGLN2, EGLN3, HIF1A, HIF3A, EP300, EPAS1
2transcription factor complexGO:00566711.2EPAS1, EP300, HIF1A, ARNT2, ARNT

Biological processes related to Hypoxia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145613.1EPAS1, CA9, EP300, HIF1AN, HIF3A, HIF1A
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141812.9EP300, HIF1AN, HIF3A, HIF1A, EGLN3, EGLN1
3response to hypoxiaGO:00166612.5ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
4bicarbonate transportGO:01570111.6CA2, CA4, CA9, CA12
5one-carbon metabolic processGO:00673011.6CA2, CA4, CA9, CA12
6response to stressGO:00695011.6CA2, HILPDA, HIGD1A, HYOU1
7regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361911.4ARNT, HIF1A, EPAS1
8peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840111.4EGLN3, EGLN1, EGLN2
9embryonic placenta developmentGO:00189211.4EPAS1, HIF1A, ARNT
10positive regulation of transcription from RNA polymerase II promoterGO:04594411.2EPAS1, EP300, HIF1A, ARNT2, ARNT
11positive regulation of hormone biosynthetic processGO:04688611.2HIF1A, ARNT
12axon transport of mitochondrionGO:01989611.1MGARP, HIF1A
13oxygen homeostasisGO:03236411.1HIF1A, EGLN1
14secretionGO:04690311.1CA9, CA2
15positive regulation of glycolysisGO:04582111.1ARNT, HIF1A
16mRNA transcription from RNA polymerase II promoterGO:04278911.0HIF1A, ARNT
17morphogenesis of an epitheliumGO:00200911.0CA9, CA2
18regulation of neuron apoptotic processGO:04352311.0EGLN2, EGLN3
19positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.9ARNT, HIF1A
20positive regulation of erythrocyte differentiationGO:04564810.9HIF1A, ARNT
21positive regulation vascular endothelial growth factor productionGO:01057510.8ARNT, HIF1A

Molecular functions related to Hypoxia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:00408911.6CA12, CA9, CA4, CA2
2L-ascorbic acid bindingGO:03141811.6P4HTM, EGLN3, EGLN1, EGLN2
3iron ion bindingGO:00550611.5EGLN1, EGLN3, P4HTM, HIF1AN
4zinc ion bindingGO:00827011.4CA2, CA4, CA9, CA12, HIF1AN, EP300
5signal transducer activityGO:00487111.4ARNT2, HIF1A, HIF3A, EPAS1
6transcription factor bindingGO:00813411.4EPAS1, EP300, HIF1A, ARNT
7peptidyl-proline 4-dioxygenase activityGO:03154511.3EGLN2, EGLN1, EGLN3
8protein heterodimerization activityGO:04698211.3EPAS1, HIF1A, ARNT2, ARNT
9aryl hydrocarbon receptor bindingGO:01716211.1ARNT2, ARNT
10oxygen sensor activityGO:01982611.1HIF1AN, EGLN2
11histone acetyltransferase bindingGO:03503510.9HIF1A, EPAS1
12oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donGO:01670610.8EGLN2, P4HTM

Products for genes affiliated with Hypoxia

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  • Antibodies

Sources for Hypoxia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet