MCID: HYP266
MIFTS: 58

Hypoxia malady

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Summaries for Hypoxia

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Novus Biologicals:45 Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to a lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1 alpha and HIF-1 beta. HIF-1 alpha accumulates under hypoxic conditions whereas HIF-1 beta is constitutively expressed. HIF-1 alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regulation of a number of factors important for solid tumor expansion including the angiogenic factor VEGF.

MalaCards based summary: Hypoxia is related to prostate cancer and breast cancer. An important gene associated with Hypoxia is EGLN2 (egl-9 family hypoxia-inducible factor 2), and among its related pathways are Angiogenesis and O2/CO2 exchange in erythrocytes. The compounds chlorothiazide and dorzolamide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and breast, and related mouse phenotypes are respiratory system and renal/urinary system.

NINDS:43 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

Aliases & Classifications for Hypoxia

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Hypoxia, Aliases & Descriptions:

Name: Hypoxia 43 62


Related Diseases for Hypoxia

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Graphical network of the top 20 diseases related to Hypoxia:



Diseases related to hypoxia

Symptoms for Hypoxia

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Drugs & Therapeutics for Hypoxia

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Drug clinical trials:

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Genetic Tests for Hypoxia

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Anatomical Context for Hypoxia

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MalaCards organs/tissues related to Hypoxia:

32
Endothelial, Brain, Breast, Lung, Prostate, Smooth muscle, Heart, Colon, Kidney, Monocytes, Bone, Placenta, Cortex, Liver, Neutrophil, T cells, Adipocyte, Skeletal muscle, Myeloid, Cervix, Pituitary, Thyroid, Skin, Bone marrow, Lymph node, B cells, Retina, Spinal cord, Cardiac myocytes, Tongue, Testes, Salivary gland, Testis, Amygdala, Fetal liver, Fetal lung, Bronchial epithelium, Eye, Whole blood, Spleen, Pancreas, Ovary, Nk cells

Animal Models for Hypoxia or affiliated genes

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Publications for Hypoxia

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Articles related to Hypoxia:

(show top 50)    (show all 5508)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1I+. (23865743)
2013
3
Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. (23395002)
2013
4
Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. (23211660)
2013
5
Metabolic and locomotor responses of juvenile paddlefish Polyodon spathula to hypoxia and temperature. (24368135)
2013
6
Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental pediatric cardiac arrest in rats. (24226633)
2013
7
Negative regulation of NEP expression by hypoxia. (23138928)
2013
8
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (23999440)
2013
9
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. (22120717)
2012
10
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. (22763238)
2012
11
Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells. (21903341)
2011
12
Effect of hypoxia on endothelial nitric oxide synthase, NO production, intracellular survival signaling (p-ERK1/2 and p-AKT) and apoptosis in human term trophoblast. (20618177)
2011
13
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
14
Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. (20952681)
2010
15
Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity. (20600586)
2010
16
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (19528298)
2009
17
Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. (19592461)
2009
18
Twist: a new link from hypoxia to fibrosis. (19483748)
2009
19
Hypoxia-altered signaling pathways of toll-like receptor 4 (TLR4) in human corneal epithelial cells. (19960069)
2009
20
Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. (18776724)
2009
21
The role of hypoxia in the differentiation of P19 embryonal carcinoma cells into dopaminergic neurons. (18465225)
2008
22
Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx. (18293086)
2008
23
Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes. (17658463)
2007
24
Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. (17904921)
2007
25
Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. (17009333)
2007
26
Proteomic analysis of hypoxia-induced responses in the syncytialization of human placental cell line BeWo. (17098281)
2007
27
HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia]. (17100286)
2006
28
Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy. (17219956)
2006
29
Hypoxia-sensitive domain in the human cytosolic phospholipase A2 promoter. (16462602)
2006
30
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)
2006
31
Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption. (16236026)
2006
32
Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression. (17085645)
2006
33
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. (16520989)
2006
34
Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. (15656883)
2005
35
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. (15967109)
2005
36
A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. (15572379)
2005
37
No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study. (15623945)
2004
38
Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (15598882)
2004
39
Regulating effect of gamma-aminobutyric acid and pyrrolidone-2 on endogenous blood metalloproteins with anti- and pro-oxidant activity in hypoxia]. (15079905)
2004
40
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin. (14581369)
2003
41
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. (12811834)
2003
42
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
43
Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. (12682078)
2003
44
Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. (12477712)
2003
45
The role of enzymatic features of hypoxia in ulcers]. (12712614)
2003
46
The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. (11953885)
2002
47
p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. (10912790)
2000
48
Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells. (10737607)
2000
49
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
50
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. (10582706)
1999

Variations for Hypoxia

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Expression for genes affiliated with Hypoxia

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Expression patterns in normal tissues for genes affiliated with Hypoxia

Search GEO for disease gene expression data for Hypoxia.

Pathways for genes affiliated with Hypoxia

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Pathways related to Hypoxia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Angiogenesis37
10.3HIF1A, ARNT
2
Show member pathways
10.3CA2, CA4
3
Show member pathways
10.3CA4, CA2
410.3ARNT, EP300
5
Show member pathways
VEGFR1 specific signals37
10.2HIF1A, EPAS1, ARNT
610.2HIF1A, EP300, ARNT
7
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
10.2ARNT, EP300, HIF1A
810.1CA12, CA2, CA9
910.0HIF1A, HIF3A, HIF1AN, ARNT
10
Show member pathways
10.0CA12, CA2, CA4, CA9
119.9HIF1A, HIF1AN, EP300, EGLN1, EGLN2, ARNT
129.8HIF1A, EP300, EGLN3, EGLN1, EGLN2, ARNT
139.8HIF1A, HIF1AN, EP300, CA9, EGLN1, ARNT
149.8HIF1A, EP300, CA9, EGLN3, EGLN1, ARNT
159.7HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
169.7HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
179.7HIF1AN, ARNT, EGLN2, EGLN1, EGLN3, EP300
189.7HIF1A, HIF1AN, EPAS1, CA9, CA12, EGLN1
19
Show member pathways
9.3ARNT, EGLN2, EGLN1, EGLN3, CA9, EP300
20
Show member pathways
9.3EP300, EPAS1, HIF1AN, HIF3A, HIF1A, CA9

Compounds for genes affiliated with Hypoxia

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Compounds related to Hypoxia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1chlorothiazide28 1111.5CA2, CA4
2dorzolamide44 1111.5CA9, CA4, CA2
3bendroflumethiazide44 1111.5CA2, CA4
4brinzolamide44 1111.5CA9, CA4, CA2
5dichlorphenamide44 1111.5CA9, CA4, CA2
6ethoxzolamide44 1111.5CA9, CA4, CA2
7methazolamide44 1111.5CA2, CA4, CA9
8vitamin c50 1111.4P4HTM, EGLN3, EGLN1, EGLN2
9L-Proline24 1111.4P4HTM, EGLN3, EGLN1, EGLN2
10acetazolamide44 1111.4CA2, CA4, CA9
11pimonidazole4410.4HIF1A, CA9
12cobalt44 2411.4ARNT, CA2, HIF1AN, HIF1A
13cocl24410.4ARNT, HIF1A
14u 1046110.4CA9, CA4, CA2, CA12
15Carbonic acid2410.4CA9, CA4, CA2, CA12
16sodium bicarbonate44 1111.4CA9, CA4, CA2
17asparagine4410.4EGLN1, EP300, HIF1AN, HIF1A
18ellagic acid44 61 1112.4CA12, CA2, CA4, CA9
19hydroxyproline44 24 1112.4P4HTM, EGLN3, EGLN1, EGLN2
20hydrochlorothiazide44 28 50 24 1114.4CA9, CA4, CA2, CA12
21sulfonamide4410.4CA2, CA4, CA9
22cyclothiazide44 28 1112.4CA4, CA2
23alpha-ketoglutarate4410.4EGLN2, EGLN1, EGLN3, HIF1AN, HIF1A
24zonisamide44 50 1112.4CA12, CA2, CA4, CA9
25topiramate44 50 24 1113.3CA2, CA4
26bicarbonate4410.3CA9, CA4, CA2, CA12
27carbon dioxide44 2411.3HIF1AN, CA9, CA4, CA2, CA12
28ascorbic acid44 2411.3HIF1A, P4HTM, EGLN3, EGLN1, EGLN2
29iron44 2411.2HIF1A, HIF1AN, EPAS1, EGLN2, ARNT
30chloride4410.1CA2, CA4, CA9
31zinc44 2411.0EP300, CA9, CA4, CA2, CA12, EGLN1
32glucose4410.0HIF1A, EPAS1, EP300, CA9, HYOU1, ARNT
33estrogen4410.0HIF1A, EP300, CA9, CA2, CA12, EGLN1
34hydrogen44 2411.0CA9, CA4, CA2, HYOU1
35proline449.9EGLN2, HIF1A, HIF1AN, P4HTM, EP300, CA9
36lactate449.9ARNT, CA2, CA9, HIF1A
37pyruvate449.9HIF1A, CA2, EGLN1
38vegf449.9HIF1A, EPAS1, EP300, CA9, HYOU1, EGLN3
39tyrosine449.8HIF1A, EPAS1, EP300, CA9, CA2, HYOU1
40oxygen44 2410.6HIF1A, HIF1AN, P4HTM, EPAS1, CA9, CA2

GO Terms for genes affiliated with Hypoxia

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Cellular components related to Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:01632310.1CA2, CA4, CA9
2transcription factor complexGO:00566710.0HIF1A, EPAS1, EP300, ARNT
3nucleoplasmGO:0056549.7ARNT, EGLN2, EGLN3, EP300, EPAS1, HIF3A
4cytosolGO:0058299.3HIF1A, HIF3A, HIF1AN, EPAS1, CA2, EGLN3

Biological processes related to Hypoxia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of hormone biosynthetic processGO:04688610.5ARNT, HIF1A
2oxygen homeostasisGO:03236410.5EGLN1, HIF1A
3axon transport of mitochondrionGO:01989610.5HIF1A, MGARP
4regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.5HIF1A, EPAS1, ARNT
5peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.4EGLN2, EGLN1, EGLN3
6embryonic placenta developmentGO:00189210.4HIF1A, EPAS1, ARNT
7positive regulation of glycolytic processGO:04582110.4ARNT, HIF1A
8secretionGO:04690310.4CA9, CA2
9mRNA transcription from RNA polymerase II promoterGO:04278910.4HIF1A, ARNT
10bicarbonate transportGO:01570110.3CA9, CA4, CA2, CA12
11one-carbon metabolic processGO:00673010.3CA9, CA4, CA2, CA12
12morphogenesis of an epitheliumGO:00200910.3CA9, CA2
13positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.3ARNT, HIF1A
14positive regulation of erythrocyte differentiationGO:04564810.3ARNT, HIF1A
15response to stressGO:00695010.3HYOU1, HIGD1A, HILPDA
16regulation of neuron apoptotic processGO:04352310.1EGLN3, EGLN2
17response to hypoxiaGO:00166610.1HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
18positive regulation vascular endothelial growth factor productionGO:01057510.0ARNT, HIF1A
19regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.7EGLN2, EGLN1, EGLN3, CA9, EP300, EPAS1
20cellular response to hypoxiaGO:0714569.5ARNT, MGARP, EGLN2, EGLN1, EGLN3, CA9

Molecular functions related to Hypoxia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1oxygen sensor activityGO:01982610.5EGLN2, HIF1AN
2peptidyl-proline 4-dioxygenase activityGO:03154510.4EGLN2, EGLN1, EGLN3
3nuclear hormone receptor bindingGO:03525710.3EP300, HIF1A
4L-ascorbic acid bindingGO:03141810.3P4HTM, EGLN3, EGLN1, EGLN2
5NF-kappaB bindingGO:05105910.3EP300, HIF1AN
6carbonate dehydratase activityGO:00408910.2CA12, CA2, CA4, CA9
7iron ion bindingGO:00550610.2HIF1AN, P4HTM, EGLN3, EGLN1
8histone acetyltransferase bindingGO:03503510.2HIF1A, EPAS1
9transcription factor bindingGO:00813410.2HIF1A, EPAS1, EP300, ARNT
10oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsGO:01670610.0P4HTM, EGLN2
11zinc ion bindingGO:0082709.9HIF1AN, EP300, CA9, CA4, CA2, CA12
12protein bindingGO:0055159.3EPAS1, HIF1AN, HILPDA, HIF1A, MGARP, EP300

Products for genes affiliated with Hypoxia

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Sources for Hypoxia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet