MCID: HYP266
MIFTS: 43

Hypoxia malady

Summaries for Hypoxia

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43NINDS, 45Novus Biologicals, 32MalaCards
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Novus Biologicals:45 Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to a lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1 alpha and HIF-1 beta. HIF-1 alpha accumulates under hypoxic conditions whereas HIF-1 beta is constitutively expressed. HIF-1 alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regulation of a number of factors important for solid tumor expansion including the angiogenic factor VEGF.

MalaCards: Hypoxia is related to breast cancer and pancreatitis. An important gene associated with Hypoxia is EGLN2 (egl-9 family hypoxia-inducible factor 2), and among its related pathways are Cellular response to hypoxia and Development HGF signaling pathway. The compounds oxygen and proline have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

NINDS:43 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

Aliases & Classifications for Hypoxia

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43NINDS, 60UMLS
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Aliases & Descriptions:

hypoxia 43 60


Related Diseases for Hypoxia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hypoxia:



Diseases related to hypoxia

Clinical Features for Hypoxia

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Drugs & Therapeutics for Hypoxia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hypoxia

Drug clinical trials:

Search ClinicalTrials for Hypoxia

Search NIH Clinical Center for Hypoxia

Search CenterWatch for Hypoxia

Genetic Tests for Hypoxia

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Anatomical Context for Hypoxia

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32MalaCards
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MalaCards organs/tissues related to Hypoxia:

32
Brain, Heart

Animal Models for Hypoxia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hypoxia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.2HYOU1, CA2, CA4, ARNT, ARNT2, EGLN2
2MP:001076813.1ARNT, CA12, CA9, CA4, CA2, ARNT2
3MP:000538512.4ARNT, EGLN2, EGLN1, EGLN3, HIF1A, HIF3A
4MP:000536912.3EGLN2, EGLN1, EGLN3, HIF1A, HIF3A, HIF1AN
5MP:000538412.1ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
6MP:000537012.0ARNT, EGLN2, EGLN1, EGLN3, HIF1A, HIF1AN
7MP:000538011.8ARNT, EGLN2, EGLN1, EGLN3, HIF1A, EP300
8MP:000538811.3EPAS1, EP300, HIF3A, HIF1A

Publications for Hypoxia

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Genetic Variations for Hypoxia

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Expression for genes affiliated with Hypoxia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hypoxia

Search GEO for disease gene expression data for Hypoxia.

Pathways for genes affiliated with Hypoxia

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Hypoxia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
12.6EPAS1, CA9, ARNT, EGLN2, EGLN1, EGLN3
2
Hide members
12.2ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
312.2ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
411.9ARNT, EGLN2, EGLN1, EGLN3, HIF1AN, EP300
511.9CA9, CA12, ARNT, EGLN1, HIF1A, HIF1AN
611.7ARNT, EGLN2, EGLN1, HIF1A, HIF1AN, EP300
711.7ARNT, EGLN2, EGLN1, EGLN3, HIF1A, EP300
811.7CA9, ARNT, EGLN1, HIF1A, HIF1AN, EP300
911.7CA9, ARNT, EGLN1, EGLN3, HIF1A, EP300
1011.3ARNT, HIF1A, HIF3A, HIF1AN
1111.1EPAS1, HIF1AN, HIF1A
12
Hide members
11.1EPAS1, HIF1A, ARNT
13
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
11.1ARNT, HIF1A, EP300
1411.1EP300, HIF1A, ARNT
15
Hide members
11.1CA2, CA4, CA9
16
Hide members
10.9CA4, CA2

Compounds for genes affiliated with Hypoxia

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Hypoxia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1oxygen44 2414.4HYOU1, CA2, CA9, ARNT, ARNT2, EGLN2
2proline4412.8CA2, CA9, EGLN2, EGLN1, EGLN3, P4HTM
3vegf4412.8CA9, ARNT, EGLN2, EGLN1, EGLN3, HIF1A
4zinc44 2413.3CA2, CA4, CA9, CA12, ARNT, EGLN1
5tyrosine4411.9HYOU1, EPAS1, EP300, HIF1A, ARNT, CA9
6alpha-ketoglutarate4411.9EGLN2, EGLN1, EGLN3, HIF1A, HIF1AN
7carbon dioxide44 2412.9CA2, CA4, CA9, CA12, HIF1AN
8ascorbic acid44 2412.8HIF1A, P4HTM, EGLN3, EGLN1, EGLN2
9u 1045911.7CA2, CA4, CA9, CA12
10Benzthiazide1111.7CA2, CA4, CA9, CA12
11Hydroflumethiazide1111.7CA2, CA4, CA9, CA12
12iron44 2412.7ARNT, EGLN2, HIF1A, HIF1AN, EPAS1
13vitamin c49 1112.7EGLN2, EGLN1, EGLN3, P4HTM
14ellagic acid44 59 1113.7CA12, CA9, CA4, CA2
15L-Proline11 2412.7EGLN2, EGLN1, EGLN3, P4HTM
16hydrochlorothiazide44 49 28 11 2415.7CA2, CA4, CA9, CA12
17zonisamide44 1112.7CA2, CA4, CA9, CA12
18cobalt44 2412.7CA2, ARNT, HIF1A, HIF1AN
19hydroxyproline44 11 2413.7EGLN2, EGLN1, EGLN3, P4HTM
20bicarbonate4411.6CA2, CA4, CA9, CA12
21glucose4411.6CA9, ARNT, HIF1A, EP300, EPAS1, HYOU1
22asparagine4411.6EGLN1, HIF1A, HIF1AN, EP300
23dorzolamide44 1112.5CA2, CA4, CA9
24brinzolamide44 1112.5CA2, CA4, CA9
25dichlorphenamide44 1112.5CA2, CA4, CA9
26ethoxzolamide44 1112.5CA9, CA4, CA2
27methazolamide44 1112.5CA9, CA4, CA2
28acetazolamide44 1112.4CA9, CA4, CA2
29sodium bicarbonate44 1112.4CA9, CA4, CA2
30sulfonamide4411.4CA2, CA4, CA9
31N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE1111.2HIF1A, EGLN1
32Methyclothiazide1111.1CA2, CA4
33chlorothiazide28 1112.1CA4, CA2
34Trichlormethiazide1111.1CA4, CA2
35bendroflumethiazide44 1112.0CA4, CA2
36pimonidazole4411.0HIF1A, CA9
37cocl24411.0ARNT, HIF1A
38estrogen4410.9CA2
39cyclothiazide28 44 1112.9CA4, CA2
40topiramate44 11 2412.6CA2, CA4

GO Terms for genes affiliated with Hypoxia

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16Gene Ontology
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Cellular components related to Hypoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565411.9EGLN2, EGLN3, HIF1A, HIF3A, EP300, EPAS1
2transcription factor complexGO:00566711.2EPAS1, EP300, HIF1A, ARNT2, ARNT

Biological processes related to Hypoxia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145613.1EPAS1, CA9, EP300, HIF1AN, HIF3A, HIF1A
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141812.9EP300, HIF1AN, HIF3A, HIF1A, EGLN3, EGLN1
3response to hypoxiaGO:00166612.5ARNT, ARNT2, EGLN2, EGLN1, EGLN3, HIF1A
4bicarbonate transportGO:01570111.6CA2, CA4, CA9, CA12
5one-carbon metabolic processGO:00673011.6CA2, CA4, CA9, CA12
6response to stressGO:00695011.6CA2, HILPDA, HIGD1A, HYOU1
7regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361911.4ARNT, HIF1A, EPAS1
8peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840111.4EGLN3, EGLN1, EGLN2
9embryonic placenta developmentGO:00189211.4EPAS1, HIF1A, ARNT
10positive regulation of transcription from RNA polymerase II promoterGO:04594411.2EPAS1, EP300, HIF1A, ARNT2, ARNT
11positive regulation of hormone biosynthetic processGO:04688611.2HIF1A, ARNT
12axon transport of mitochondrionGO:01989611.1MGARP, HIF1A
13oxygen homeostasisGO:03236411.1HIF1A, EGLN1
14secretionGO:04690311.1CA9, CA2
15positive regulation of glycolysisGO:04582111.1ARNT, HIF1A
16mRNA transcription from RNA polymerase II promoterGO:04278911.0HIF1A, ARNT
17morphogenesis of an epitheliumGO:00200911.0CA9, CA2
18regulation of neuron apoptotic processGO:04352311.0EGLN2, EGLN3
19positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.9ARNT, HIF1A
20positive regulation of erythrocyte differentiationGO:04564810.9HIF1A, ARNT
21positive regulation vascular endothelial growth factor productionGO:01057510.8ARNT, HIF1A

Molecular functions related to Hypoxia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:00408911.6CA12, CA9, CA4, CA2
2L-ascorbic acid bindingGO:03141811.6P4HTM, EGLN3, EGLN1, EGLN2
3iron ion bindingGO:00550611.5EGLN1, EGLN3, P4HTM, HIF1AN
4zinc ion bindingGO:00827011.4CA2, CA4, CA9, CA12, HIF1AN, EP300
5signal transducer activityGO:00487111.4ARNT2, HIF1A, HIF3A, EPAS1
6transcription factor bindingGO:00813411.4EPAS1, EP300, HIF1A, ARNT
7peptidyl-proline 4-dioxygenase activityGO:03154511.3EGLN2, EGLN1, EGLN3
8protein heterodimerization activityGO:04698211.3EPAS1, HIF1A, ARNT2, ARNT
9aryl hydrocarbon receptor bindingGO:01716211.1ARNT2, ARNT
10oxygen sensor activityGO:01982611.1HIF1AN, EGLN2
11histone acetyltransferase bindingGO:03503510.9HIF1A, EPAS1
12oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donGO:01670610.8EGLN2, P4HTM

Products for genes affiliated with Hypoxia

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Sources for Hypoxia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet