Hypoxia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: HYP266 MIFTS: 57	Hypoxia malady
43 genes, 43 tissues, 429 related diseases, clinical trials Download this MalaCard Expand all tables

Summaries for Hypoxia

Sources:
⁴³NINDS, ⁴⁵Novus Biologicals, ³²MalaCards
See all sources

Novus Biologicals:⁴⁵ Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to a lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1 alpha and HIF-1 beta. HIF-1 alpha accumulates under hypoxic conditions whereas HIF-1 beta is constitutively expressed. HIF-1 alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regulation of a number of factors important for solid tumor expansion including the angiogenic factor VEGF.

MalaCards based summary: Hypoxia is related to prostate cancer and breast cancer. An important gene associated with Hypoxia is EGLN2 (egl-9 family hypoxia-inducible factor 2), and among its related pathways are Angiogenesis and O2/CO2 exchange in erythrocytes. The compounds chlorothiazide and dorzolamide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and breast, and related mouse phenotypes are respiratory system and renal/urinary system.

NINDS:⁴³ Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

Aliases & Classifications for Hypoxia

Sources:
⁴³NINDS, ⁶¹UMLS
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Hypoxia, Aliases & Descriptions:

Name: Hypoxia ⁴³ ⁶¹

Related Diseases for Hypoxia

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Hypoxia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 429)

id	Related Disease	Score	Top Affiliating Genes
1	prostate cancer	31.4	EPAS1, HIF1A, EP300, CA9, HYOU1, ARNT
2	breast cancer	31.4	CA9, HIF1A, EPAS1, EP300
3	cervical cancer	31.1	EP300, CA9, HIF1A
4	osteosarcoma	30.8	EP300, CA2, EGLN3, EGLN1, HIF1A
5	fibrosarcoma	30.7	HIF1A, CA9, EP300
6	erythrocytosis	30.7	HIF1A
7	endometrial carcinoma	30.7	CA9, EP300, HIF1A
8	kidney cancer	30.4	HIF1A, HIF1AN, CA12, EPAS1, CA9
9	endotheliitis	11.2
10	cerebritis	11.0
11	cerebral hypoxia	11.0
12	ischemia	11.0
13	neuronitis	10.8
14	prostatitis	10.8
15	pancreatitis	10.7
16	lung cancer	10.7
17	hypertension	10.7
18	adenocarcinoma	10.7
19	pancreatic cancer	10.7
20	hepatocellular carcinoma	10.7
21	retinitis	10.7
22	renal cell carcinoma	10.6
23	glioblastoma	10.6
24	pulmonary hypertension	10.6
25	melanoma	10.6
26	cervicitis	10.6
27	neuroblastoma	10.6
28	gastric cancer	10.6
29	anoxia	10.6
30	ovarian cancer	10.5
31	colorectal cancer	10.5
32	colon cancer	10.5
33	acute mountain sickness	10.5
34	sarcoma	10.5
35	hepatitis	10.5
36	esophagitis	10.5
37	brain injury	10.4
38	leukemia	10.4
39	oral squamous cell carcinoma	10.4
40	lung adenocarcinoma	10.4
41	sleep apnea	10.4
42	eclampsia	10.4
43	laryngitis	10.4
44	pre-eclampsia	10.4
45	obesity	10.3
46	esophageal squamous cell carcinoma	10.3
47	traumatic brain injury	10.3
48	adenoma	10.3
49	thyroiditis	10.3
50	clear cell renal cell carcinoma	10.3

Graphical network of the top 20 diseases related to Hypoxia:

Symptoms for Hypoxia

Drugs & Therapeutics for Hypoxia

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Hypoxia

Search NIH Clinical Center for Hypoxia

Genetic Tests for Hypoxia

Anatomical Context for Hypoxia

Sources:
³²MalaCards
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MalaCards organs/tissues related to Hypoxia:

³²

Endothelial, Brain, Breast, Lung, Prostate, Smooth muscle, Heart, Colon, Kidney, Monocytes, Bone, Placenta, Cortex, Liver, Neutrophil, T cells, Adipocyte, Skeletal muscle, Myeloid, Cervix, Pituitary, Thyroid, Skin, Bone marrow, Lymph node, B cells, Retina, Spinal cord, Cardiac myocytes, Tongue, Testes, Salivary gland, Testis, Amygdala, Fetal liver, Fetal lung, Bronchial epithelium, Eye, Whole blood, Spleen, Pancreas, Ovary, Nk cells

Animal Models for Hypoxia or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Hypoxia:

³⁶ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	HIF1A, HIF3A, HIF1AN, EPAS1, EP300, EGLN1
2	renal/urinary system phenotype	MP:0005367	10.0	ARNT, EGLN1, CA2, EP300, HIF1A
3	liver/biliary system phenotype	MP:0005370	9.9	HIF1A, HIF1AN, EPAS1, EGLN3, EGLN1, EGLN2
4	embryogenesis phenotype	MP:0005380	9.9	HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
5	muscle phenotype	MP:0005369	9.9	EGLN2, HIF1A, HIF3A, HIF1AN, EPAS1, EP300
6	craniofacial phenotype	MP:0005382	9.8	HIF1A, EP300, EGLN3, EGLN2, ARNT
7	cardiovascular system phenotype	MP:0005385	9.7	HIF1A, HIF3A, HIF1AN, EPAS1, EP300, EGLN3
8	cellular phenotype	MP:0005384	9.7	HIF1A, HIF1AN, EP300, HYOU1, EGLN3, EGLN1
9	growth/size/body phenotype	MP:0005378	9.7	HIF1A, HIF1AN, EPAS1, EP300, CA4, CA2
10	homeostasis/metabolism phenotype	MP:0005376	9.5	HIF1A, HIF1AN, EPAS1, EP300, CA4, CA2
11	hematopoietic system phenotype	MP:0005397	9.4	HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
12	mortality/aging	MP:0010768	9.4	HIF1A, EPAS1, EP300, CA9, CA4, CA2

Publications for Hypoxia

Sources:
⁵¹PubMed
See all sources

Articles related to Hypoxia:

(show top 50) (show all 5508)

id	Title	Authors	Year
1	Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)	Taccone F.S.... De Backer D.	2014
2	CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1I+. (23865743)	Esencay M.... Zagzag D.	2013
3	Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. (23395002)	Yang F.... Sun S.H.	2013
4	Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. (23211660)	Baitharu I.... Ilavazhagan G.	2013
5	Metabolic and locomotor responses of juvenile paddlefish Polyodon spathula to hypoxia and temperature. (24368135)	Aboagye D.L.... Allen P.J.	2013
6	Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental pediatric cardiac arrest in rats. (24226633)	Manole M.D.... Clark R.S.	2013
7	Negative regulation of NEP expression by hypoxia. (23138928)	Mitra R.... Goodman O.B.	2013
8	HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (23999440)	Semenza G.L.	2013
9	Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. (22120717)	Wanka C.... Rieger J.	2012
10	Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. (22763238)	Bebee T.W.... Chandler D.S.	2012
11	Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells. (21903341)	Zhou S.... Zhao X.	2011
12	Effect of hypoxia on endothelial nitric oxide synthase, NO production, intracellular survival signaling (p-ERK1/2 and p-AKT) and apoptosis in human term trophoblast. (20618177)	Park M.H.... Arroyo J.A.	2011
13	Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)	Sato Y.... Takahashi T.	2011
14	Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. (20952681)	Gonsalves C.... Kalra V.K.	2010
15	Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity. (20600586)	Tam K.K.... Kind K.L.	2010
16	HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (19528298)	Li Y.... Rempe D.A.	2009
17	Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. (19592461)	de Frutos S.... GonzA!lez Bosc L.V.	2009
18	Twist: a new link from hypoxia to fibrosis. (19483748)	Bechtel W.... Zeisberg M.	2009
19	Hypoxia-altered signaling pathways of toll-like receptor 4 (TLR4) in human corneal epithelial cells. (19960069)	Hara Y.... Ohashi Y.	2009
20	Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. (18776724)	Teramo K.A.... Widness J.A.	2009
21	The role of hypoxia in the differentiation of P19 embryonal carcinoma cells into dopaminergic neurons. (18465225)	Wu L.Y.... Zhu L.L.	2008
22	Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx. (18293086)	Delivoria-Papadopoulos M.... Mishra O.P.	2008
23	Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes. (17658463)	Wood I.S.... Trayhurn P.	2007
24	Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. (17904921)	Boraldi F.... Quaglino D.	2007
25	Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. (17009333)	Kim B.J.... Forbes N.S.	2007
26	Proteomic analysis of hypoxia-induced responses in the syncytialization of human placental cell line BeWo. (17098281)	Hu R.... Li X.	2007
27	HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia]. (17100286)	Bobarykina A.I.u.... Minchenko O.H.	2006
28	Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy. (17219956)	Zhang W.... Zhang H.	2006
29	Hypoxia-sensitive domain in the human cytosolic phospholipase A2 promoter. (16462602)	Alexandrov P.N.... Lukiw W.J.	2006
30	Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)	Kageyama Y.... Kihara K.	2006
31	Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption. (16236026)	Sarri E.... Soler-Soler J.	2006
32	Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression. (17085645)	Lee J.... Lee H.Y.	2006
33	Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. (16520989)	Yang B.... He Q.	2006
34	Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. (15656883)	Bos R.... van der Wall E.	2005
35	Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. (15967109)	Robey I.F.... Gillies R.J.	2005
36	A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. (15572379)	Brusselmans K.... Dewerchin M.	2005
37	No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study. (15623945)	Vleugel M.M.... van Diest P.J.	2004
38	Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (15598882)	Fukasawa M.... Seki S.	2004
39	Regulating effect of gamma-aminobutyric acid and pyrrolidone-2 on endogenous blood metalloproteins with anti- and pro-oxidant activity in hypoxia]. (15079905)	Manukian A.A.... Simonian G.M.	2004
40	Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin. (14581369)	Azuma Y.... Raleigh J.A.	2003
41	Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. (12811834)	Zagzag D.... Newcomb E.W.	2003
42	Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)	Giatromanolaki A.... Koukourakis M.I.	2003
43	Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. (12682078)	Bontemps Y.... Wegrowski Y.	2003
44	Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. (12477712)	Denko N.... Barton M.C.	2003
45	The role of enzymatic features of hypoxia in ulcers]. (12712614)	Borzenko B.G.... Dudin A.M.	2003
46	The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. (11953885)	Turner K.J.... Harris A.L.	2002
47	p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. (10912790)	Denko N.C.... Giaccia A.J.	2000
48	Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells. (10737607)	Amoroso S.... Annunziato L.	2000
49	Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)	Tuor U.I.... Kozlowski P.	1999
50	Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. (10582706)	Zhong H.... Simons J.W.	1999

Genes related to Hypoxia

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Hypoxia:

(show all 43)

- Elite gene

id	Symbol	Description	Score	Implication
1	EGLN2	egl-9 family hypoxia-inducible factor 2	20.29	GeneCards inferred via : Publications, Functions, Pathways & Interactions, Gene name, Products, Summaries (show sections)
2	EGLN1	egl-9 family hypoxia-inducible factor 1	19.83	GeneCards inferred via : Publications, Functions, Pathways & Interactions, Gene name, Products, Summaries (show sections)
3	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	19.36	GeneCards inferred via : Proteins, Publications, Functions, Summaries, Expressions, Pathways & Interactions, Disorders, Gene name, Products (show sections)
4	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	18.88	GeneCards inferred via : Publications, Functions, Pathways & Interactions, Gene name, Products, Proteins (show sections)
5	EPAS1	endothelial PAS domain protein 1	18.41	GeneCards inferred via : Publications, Pathways & Interactions, Gene name, Functions (show sections)
6	CA4	carbonic anhydrase IV	17.93	GeneCards inferred via : Summaries, Publications (show sections)
7	EP300	E1A binding protein p300	17.46	GeneCards inferred via : Publications, Summaries, Pathways & Interactions, Proteins (show sections)
8	CA12	carbonic anhydrase XII	17.00	GeneCards inferred via : Summaries, Publications (show sections)
9	CA2	carbonic anhydrase II	16.53	GeneCards inferred via : Summaries, Publications (show sections)
10	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	16.11	GeneCards inferred via : Publications, Summaries, Gene name, Functions (show sections)
11	ARNT	aryl hydrocarbon receptor nuclear translocator	15.64	GeneCards inferred via : Publications, Pathways & Interactions, Gene name, Functions, Products, Summaries (show sections)
12	HILPDA	hypoxia inducible lipid droplet-associated	15.17	GeneCards inferred via : Publications, Gene name, Functions (show sections)
13	HIGD1A	HIG1 hypoxia inducible domain family, member 1A	14.70	GeneCards inferred via : Proteins, Gene name, Functions (show sections)
14	HIF3A	hypoxia inducible factor 3, alpha subunit	14.23	GeneCards inferred via : Functions, Publications, Summaries, Pathways & Interactions, Gene name, Products (show sections)
15	MGARP	mitochondria-localized glutamic acid-rich protein	13.76	GeneCards inferred via : Publications, Pathways & Interactions, Gene name, Functions (show sections)
16	HYOU1	hypoxia up-regulated 1	13.30	GeneCards inferred via : Proteins, Publications, Gene name, Functions, Summaries (show sections)
17	EGLN3	egl-9 family hypoxia-inducible factor 3	12.83	GeneCards inferred via : Functions, Publications, Pathways & Interactions, Gene name, Proteins (show sections)
18	HIGD1B	HIG1 hypoxia inducible domain family, member 1B	12.36	GeneCards inferred via : Proteins, Gene name, Summaries (show sections)
19	C3orf58	chromosome 3 open reading frame 58	11.89	GeneCards inferred via : Gene name (show sections)
20	CA9	carbonic anhydrase IX	11.42	GeneCards inferred via : Publications, Summaries, Pathways & Interactions, Functions, Products (show sections)
21	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	10.95	GeneCards inferred via : Summaries, Publications, Pathways & Interactions (show sections)
22	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	10.49	GeneCards inferred via : Summaries, Publications (show sections)
23	RGS5	regulator of G-protein signaling 5	10.02	GeneCards inferred via : Summaries, Publications (show sections)
24	HIGD2B	HIG1 hypoxia inducible domain family, member 2B	9.55	GeneCards inferred via : Proteins, Gene name (show sections)
25	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	9.08	GeneCards inferred via : Proteins, Publications, Pathways & Interactions, Functions, Summaries (show sections)
26	VHLL	von Hippel-Lindau tumor suppressor-like	8.62	GeneCards inferred via : Summaries (show sections)
27	SIAH2	siah E3 ubiquitin protein ligase 2	8.15	GeneCards inferred via : Publications, Functions, Summaries (show sections)
28	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	7.69	GeneCards inferred via : Publications, Pathways & Interactions, Functions, Proteins, Summaries (show sections)
29	WDR83	WD repeat domain 83	7.22	GeneCards inferred via : Publications, Functions, Summaries (show sections)
30	UBE2D1	ubiquitin-conjugating enzyme E2D 1	6.76	GeneCards inferred via : Publications, Pathways & Interactions, Summaries (show sections)
31	SIAH1	siah E3 ubiquitin protein ligase 1	6.29	GeneCards inferred via : Publications, Summaries (show sections)
32	PROK1	prokineticin 1	5.83	GeneCards inferred via : Summaries (show sections)
33	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	5.36	GeneCards inferred via : Publications, Functions, Summaries (show sections)
34	UGDH	UDP-glucose 6-dehydrogenase	4.89	GeneCards inferred via : Publications, Summaries (show sections)
35	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	4.43	GeneCards inferred via : Summaries (show sections)
36	UQCRB	ubiquinol-cytochrome c reductase binding protein	3.96	GeneCards inferred via : Summaries (show sections)
37	CHRDL1	chordin-like 1	3.50	GeneCards inferred via : Publications, Functions, Summaries (show sections)
38	OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	3.03	GeneCards inferred via : Publications, Summaries (show sections)
39	TP53	tumor protein p53	2.57	GeneCards inferred via : Publications, Pathways & Interactions, Products, Summaries (show sections)
40	USP20	ubiquitin specific peptidase 20	2.10	GeneCards inferred via : Summaries (show sections)
41	CHEK2	checkpoint kinase 2	1.64	GeneCards inferred via : Publications, Summaries (show sections)
42	CHEK1	checkpoint kinase 1	1.17	GeneCards inferred via : Publications, Summaries (show sections)
43	EGLN1P1	egl-9 family hypoxia-inducible factor 1 pseudogene 1	0.70	GeneCards inferred via : Gene name (show sections)

Products for genes related to Hypoxia disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	38	-	40	42
2	Novus Biologicals	35	36	42	-

Variations for Hypoxia

Expression for genes affiliated with Hypoxia

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Hypoxia

Search GEO for disease gene expression data for Hypoxia.

Pathways for genes affiliated with Hypoxia

Sources:
⁴⁹PathCards, ⁵Cell Signaling Technology, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ³⁰KEGG, ⁵²QIAGEN, ⁵⁹Thomson Reuters
See all sources

Pathways related to Hypoxia according to GeneCards/GeneDecks:

(show all 20)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Angiogenesis⁵ Show member pathways Angiogenesis³⁷	10.3	HIF1A, ARNT
2	O2/CO2 exchange in erythrocytes⁵⁴ Show member pathways Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes⁵⁴ Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes⁵⁴	10.3	CA2, CA4
3	Proximal tubule bicarbonate reclamation³⁰ Show member pathways D-Glutamine and D-glutamate metabolism³⁰	10.3	CA4, CA2
4	AHR Pathway⁵²	10.3	ARNT, EP300
5	Signaling events mediated by VEGFR1 and VEGFR2³⁷ Show member pathways VEGFR1 specific signals³⁷	10.2	HIF1A, EPAS1, ARNT
6	Notch-mediated HES/HEY network³⁷	10.2	HIF1A, EP300, ARNT
7	Transcription Ligand dependent activation of the ESR1 SP pathway⁵⁹ Show member pathways Development Ligand dependent activation of the ESR1 AP 1 pathway⁵⁹	10.2	ARNT, EP300, HIF1A
8	Glucose / Energy Metabolism⁵	10.1	CA12, CA2, CA9
9	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha³⁷	10.0	HIF1A, HIF3A, HIF1AN, ARNT
10	Nitrogen metabolism³⁰ Show member pathways Reversible Hydration of Carbon Dioxide⁵⁴	10.0	CA12, CA2, CA4, CA9
11	HIF1Alpha Pathway⁵²	9.9	HIF1A, HIF1AN, EP300, EGLN1, EGLN2, ARNT
12	HIF-1 signaling pathway³⁰	9.8	HIF1A, EP300, EGLN3, EGLN1, EGLN2, ARNT
13	Angiogenesis⁵	9.8	HIF1A, HIF1AN, EP300, CA9, EGLN1, ARNT
14	HIF-1-alpha transcription factor network³⁷	9.8	HIF1A, EP300, CA9, EGLN3, EGLN1, ARNT
15	Renal cell carcinoma³⁰	9.7	HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
16	Pathways in cancer³⁰	9.7	HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
17	HIF-2-alpha transcription factor network³⁷	9.7	HIF1AN, ARNT, EGLN2, EGLN1, EGLN3, EP300
18	Translational Control⁵	9.7	HIF1A, HIF1AN, EPAS1, CA9, CA12, EGLN1
19	Cellular Senescence⁵⁴ Show member pathways Cellular responses to stress⁵⁴ Senescence-Associated Secretory Phenotype (SASP)⁵⁴ Oxidative Stress Induced Senescence⁵⁴	9.3	ARNT, EGLN2, EGLN1, EGLN3, CA9, EP300
20	Regulation of Hypoxia-inducible Factor (HIF) by Oxygen⁵⁴ Show member pathways Regulation of Gene Expression by Hypoxia-inducible Factor⁵⁴ Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha⁵⁴ Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha⁵⁴ Cellular response to hypoxia⁵⁴	9.3	EP300, EPAS1, HIF1AN, HIF3A, HIF1A, CA9

Compounds for genes affiliated with Hypoxia

Sources:
²⁹IUPHAR, ¹²DrugBank, ⁴⁴Novoseek, ⁵⁰PharmGKB, ²⁵HMDB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Hypoxia according to GeneCards/GeneDecks:

(show all 40)

id	Compound	Score	Top Affiliating Genes
1	chlorothiazide²⁹ ¹²	11.5	CA2, CA4
2	dorzolamide⁴⁴ ¹²	11.5	CA9, CA4, CA2
3	bendroflumethiazide⁴⁴ ¹²	11.5	CA2, CA4
4	brinzolamide⁴⁴ ¹²	11.5	CA9, CA4, CA2
5	dichlorphenamide⁴⁴ ¹²	11.5	CA9, CA4, CA2
6	ethoxzolamide⁴⁴ ¹²	11.5	CA9, CA4, CA2
7	methazolamide⁴⁴ ¹²	11.5	CA2, CA4, CA9
8	vitamin c⁵⁰ ¹²	11.4	P4HTM, EGLN3, EGLN1, EGLN2
9	L-Proline²⁵ ¹²	11.4	P4HTM, EGLN3, EGLN1, EGLN2
10	acetazolamide⁴⁴ ¹²	11.4	CA2, CA4, CA9
11	pimonidazole⁴⁴	10.4	HIF1A, CA9
12	cobalt⁴⁴ ²⁵	11.4	ARNT, CA2, HIF1AN, HIF1A
13	cocl2⁴⁴	10.4	ARNT, HIF1A
14	u 104⁶⁰	10.4	CA9, CA4, CA2, CA12
15	Carbonic acid²⁵	10.4	CA9, CA4, CA2, CA12
16	sodium bicarbonate⁴⁴ ¹²	11.4	CA9, CA4, CA2
17	asparagine⁴⁴	10.4	EGLN1, EP300, HIF1AN, HIF1A
18	ellagic acid⁴⁴ ⁶⁰ ¹²	12.4	CA12, CA2, CA4, CA9
19	hydroxyproline⁴⁴ ²⁵ ¹²	12.4	P4HTM, EGLN3, EGLN1, EGLN2
20	hydrochlorothiazide⁴⁴ ²⁹ ⁵⁰ ²⁵ ¹²	14.4	CA9, CA4, CA2, CA12
21	sulfonamide⁴⁴	10.4	CA2, CA4, CA9
22	cyclothiazide⁴⁴ ²⁹ ¹²	12.4	CA4, CA2
23	alpha-ketoglutarate⁴⁴	10.4	EGLN2, EGLN1, EGLN3, HIF1AN, HIF1A
24	zonisamide⁴⁴ ⁵⁰ ¹²	12.4	CA12, CA2, CA4, CA9
25	topiramate⁴⁴ ⁵⁰ ²⁵ ¹²	13.3	CA2, CA4
26	bicarbonate⁴⁴	10.3	CA9, CA4, CA2, CA12
27	carbon dioxide⁴⁴ ²⁵	11.3	HIF1AN, CA9, CA4, CA2, CA12
28	ascorbic acid⁴⁴ ²⁵	11.3	HIF1A, P4HTM, EGLN3, EGLN1, EGLN2
29	iron⁴⁴ ²⁵	11.2	HIF1A, HIF1AN, EPAS1, EGLN2, ARNT
30	chloride⁴⁴	10.1	CA2, CA4, CA9
31	zinc⁴⁴ ²⁵	11.0	EP300, CA9, CA4, CA2, CA12, EGLN1
32	glucose⁴⁴	10.0	HIF1A, EPAS1, EP300, CA9, HYOU1, ARNT
33	estrogen⁴⁴	10.0	HIF1A, EP300, CA9, CA2, CA12, EGLN1
34	hydrogen⁴⁴ ²⁵	11.0	CA9, CA4, CA2, HYOU1
35	proline⁴⁴	9.9	EGLN2, HIF1A, HIF1AN, P4HTM, EP300, CA9
36	lactate⁴⁴	9.9	ARNT, CA2, CA9, HIF1A
37	pyruvate⁴⁴	9.9	HIF1A, CA2, EGLN1
38	vegf⁴⁴	9.9	HIF1A, EPAS1, EP300, CA9, HYOU1, EGLN3
39	tyrosine⁴⁴	9.8	HIF1A, EPAS1, EP300, CA9, CA2, HYOU1
40	oxygen⁴⁴ ²⁵	10.6	HIF1A, HIF1AN, P4HTM, EPAS1, CA9, CA2

GO Terms for genes affiliated with Hypoxia

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Hypoxia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	10.1	CA2, CA4, CA9
2	transcription factor complex	GO:005667	10.0	HIF1A, EPAS1, EP300, ARNT
3	nucleoplasm	GO:005654	9.7	ARNT, EGLN2, EGLN3, EP300, EPAS1, HIF3A
4	cytosol	GO:005829	9.3	HIF1A, HIF3A, HIF1AN, EPAS1, CA2, EGLN3

Biological processes related to Hypoxia according to GeneCards/GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of hormone biosynthetic process	GO:046886	10.5	ARNT, HIF1A
2	oxygen homeostasis	GO:032364	10.5	EGLN1, HIF1A
3	axon transport of mitochondrion	GO:019896	10.5	HIF1A, MGARP
4	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO:043619	10.5	HIF1A, EPAS1, ARNT
5	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	GO:018401	10.4	EGLN2, EGLN1, EGLN3
6	embryonic placenta development	GO:001892	10.4	HIF1A, EPAS1, ARNT
7	positive regulation of glycolytic process	GO:045821	10.4	ARNT, HIF1A
8	secretion	GO:046903	10.4	CA9, CA2
9	mRNA transcription from RNA polymerase II promoter	GO:042789	10.4	HIF1A, ARNT
10	bicarbonate transport	GO:015701	10.3	CA9, CA4, CA2, CA12
11	one-carbon metabolic process	GO:006730	10.3	CA9, CA4, CA2, CA12
12	morphogenesis of an epithelium	GO:002009	10.3	CA9, CA2
13	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.3	ARNT, HIF1A
14	positive regulation of erythrocyte differentiation	GO:045648	10.3	ARNT, HIF1A
15	response to stress	GO:006950	10.3	HYOU1, HIGD1A, HILPDA
16	regulation of neuron apoptotic process	GO:043523	10.1	EGLN3, EGLN2
17	response to hypoxia	GO:001666	10.1	HIF1A, EPAS1, EP300, EGLN3, EGLN1, EGLN2
18	positive regulation vascular endothelial growth factor production	GO:010575	10.0	ARNT, HIF1A
19	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	9.7	EGLN2, EGLN1, EGLN3, CA9, EP300, EPAS1
20	cellular response to hypoxia	GO:071456	9.5	ARNT, MGARP, EGLN2, EGLN1, EGLN3, CA9

Molecular functions related to Hypoxia according to GeneCards/GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	oxygen sensor activity	GO:019826	10.5	EGLN2, HIF1AN
2	peptidyl-proline 4-dioxygenase activity	GO:031545	10.4	EGLN2, EGLN1, EGLN3
3	nuclear hormone receptor binding	GO:035257	10.3	EP300, HIF1A
4	L-ascorbic acid binding	GO:031418	10.3	P4HTM, EGLN3, EGLN1, EGLN2
5	NF-kappaB binding	GO:051059	10.3	EP300, HIF1AN
6	carbonate dehydratase activity	GO:004089	10.2	CA12, CA2, CA4, CA9
7	iron ion binding	GO:005506	10.2	HIF1AN, P4HTM, EGLN3, EGLN1
8	histone acetyltransferase binding	GO:035035	10.2	HIF1A, EPAS1
9	transcription factor binding	GO:008134	10.2	HIF1A, EPAS1, EP300, ARNT
10	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	GO:016706	10.0	P4HTM, EGLN2
11	zinc ion binding	GO:008270	9.9	HIF1AN, EP300, CA9, CA4, CA2, CA12
12	protein binding	GO:005515	9.3	EPAS1, HIF1AN, HILPDA, HIF1A, MGARP, EP300