Hypoxia malady

NINDS: Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.³¹

MalaCards: Hypoxia is related to carcinoma and neuronitis. An important gene associated with Hypoxia is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are WNT Signaling and MAPK Signaling. The compounds serine and oxygen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are no phenotypic analysis and growth/size.

hypoxia 31 43

Diseases related to hypoxia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 816)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	257.6	ZNF217, ZNF354A, PIK3CB, PIK3CD, PIGF, PIK3CA
2	neuronitis	215.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
3	prostatitis	213.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
4	leukemia	188.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
5	pancreatitis	188.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
6	adenocarcinoma	171.4	ZNF217, PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
7	melanoma	158.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
8	colorectal cancer	158.5	ZNF217, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG
9	hepatocellular carcinoma	155.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PDCD4
10	thyroiditis	146.0	PIK3CB, PIGF, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
11	ovarian cancer	144.6	ZNF217, ZNF354A, PIK3CB, PIK3CD, PIK3CA, PIK3R1
12	gastric cancer	142.4	PIK3CB, PIK3CA, PIK3R1, PIP5KL1, PIK3CG, PIM1
13	neuroblastoma	140.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
14	colon cancer	136.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, RGCC
15	alzheimer's disease	135.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIP5KL1, PIK3CG
16	ischemia	129.3	ZNF354A, PIGF, PIK3CA, PIK3C2A, PIK3CG, WDR26
17	breast carcinoma	128.9	ZNF217, PIK3CA, PIK3R1, PIK3CG, LRP1, NCOA2
18	cervicitis	127.6	ZNF217, PIK3CA, PIP5KL1, PIK3CG, PDCD4, PDE4A
19	retinitis	126.2	PIGF, PIK3CA, PIK3C2A, PIK3CG, PIM1, LRP1
20	esophagitis	124.6	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIM1, KLF5
21	cerebritis	124.2	PIGF, PIK3R1, PIK3C2A, PIK3CG, LRP1, PDE4A
22	rheumatoid arthritis	118.0	PIK3CD, PIK3CG, LRP1, LRP5, KLF5, PDE4A
23	hypertension	117.9	PIK3CB, PIK3R1, PIK3C2A, PIK3CG, PIM1, LRP1
24	fibrosis	116.2	PIK3CA, PIK3CG, LRP1, PDE4A, RECK, RELA
25	sarcoma	112.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
26	adenoma	107.6	PIK3CA, NCOA1, NCOA2, PDCD4, PDE4A, RECK
27	atherosclerosis	105.8	PIK3C2A, PIK3CG, LRP1, LRP5, KLF2, KLF5
28	myeloid leukemia	105.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
29	myeloma	102.2	PIK3CA, PIK3R1, PIK3CG, LRP1, LRP5, PDE4A
30	squamous cell carcinoma	100.5	PIK3CB, PIK3CA, PIM1, RECK, RELA, VTN
31	hepatitis b	100.4	PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIM1, RELA
32	obesity	99.9	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
33	ovarian carcinoma	99.9	PIGF, PIK3CA, PIP5KL1, PIK3CG, NDN, PDCD4
34	cervical cancer	96.5	ZNF217, PIK3CA, PIP5KL1, PIK3CG, RELA, VTN
35	osteosarcoma	95.8	PIK3CB, PIK3CA, PIK3CG, LRP5, NCOA1, PDE4A
36	asthma	94.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
37	colon carcinoma	93.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, PDCD4
38	lung carcinoma	93.6	PIK3CA, PIK3R1, PIK3CG, RECK, SFTPB, PCNA
39	schizophrenia	93.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF5, PDE4A
40	diabetes mellitus	92.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
41	astrocytoma	90.6	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF16, RECK
42	multiple myeloma	85.9	PIK3CA, PIK3R1, PIK3CG, LRP1, RECK, RELA
43	oral squamous cell carcinoma	85.2	PIK3CA, PIK3C2A, PIM1, PDCD4, RECK, VTN
44	retinoblastoma	83.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NDN
45	insulin resistance	83.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, RELA
46	prostate carcinoma	83.3	PIK3R1, PIK3CG, PIM1, LRP1, RECK, RELA
47	myocardial infarction	82.9	PIK3C2A, PIK3CG, LRP1, PDE4A, RECK, REN
48	peritonitis	82.2	PIK3C2A, LRP1, RELA, REN, RET, KIT
49	gonococcal synovitis	81.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, NCOA1
50	nasopharyngitis	81.5	PIK3CA, PIK3CG, KLF5, NCAPG, RECK, RELA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hypoxia:

²²

MGI Mouse Phenotypes related to hypoxia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	INF	PIK3CD, PIK3R1, NDN, NCOA2, RET, SFRP1
2	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIM1
3	normal phenotype	MP:0002873	INF	PIK3R1, LRP1, , KLF2, KLF5, NDN
4	vision/eye phenotype	MP:0005391	INF	PIK3CA, , RELA, KIT, KITLG, SFTPC
5	reproductive system phenotype	MP:0005389	INF	PIK3CA, NCOA1, NCOA2, PDCD4, REN, RET
6	renal/urinary system phenotype	MP:0005367	INF	KLF1, NCOA1, PDCD4, REN, RET, KIT
7	endocrine/exocrine gland phenotype	MP:0005379	INF	, KLF5, NCOA1, NCOA2, PDCD4, RET
8	hematopoietic system phenotype	MP:0005397	47.5	PIAS4, PIM1, KLF1, KLF2, KIT, SFRP1
9	adipose tissue phenotype	MP:0005375	30.3	PIK3CA, PIK3R1, PIK3C2A, LRP1, SFRP1, RB1
10	respiratory system phenotype	MP:0005388	27.7	KLF2, KLF5, NDN, RET, SFTPC, SESN2
11	other phenotype	MP:0005395	17.2	RECK, VASP, RARA, CLU, KDR, SCNN1G
12	digestive/alimentary phenotype	MP:0005381	INF	KLF5, RET, RETNLB, KIT, KITLG, VWF
13	integument phenotype	MP:0010771	INF	PIK3CG, KLF1, NDN, NCOA1, NCOA2, RECK
14	limbs/digits/tail phenotype	MP:0005371	INF	, RECK, RELA, RET, KIT, KITLG
15	embryogenesis phenotype	MP:0005380	INF	PIK3CB, PIK3CA, , KLF1, KLF2, KLF5
16	tumorigenesis	MP:0002006	INF	PIK3CB, PIK3CA, PIK3R1, PDCD4, RET, KIT
17	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
18	cellular phenotype	MP:0005384	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIM1
19	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF2, KLF5
20	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
21	hearing/vestibular/ear phenotype	MP:0005377	INF	KIT, KITLG, RB1, LMNA, MYC, BMP2
22	immune system phenotype	MP:0005387	INF	PIK3CD, PIAS4, LRP1, , KLF1, KLF2
23	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, PIAS4, PIK3C2A, LRP1,
24	nervous system phenotype	MP:0003631	INF	LRP1, , NDN, NCOA1, PDE4A, RECK
25	skeleton phenotype	MP:0005390	INF	PIK3CD, PIK3CG, LRP1, KLF2, NCOA1, RECK
26	liver/biliary system phenotype	MP:0005370	INF	, KLF1, KLF2, RECK, KIT, SEL1L
27	craniofacial phenotype	MP:0005382	INF	, KLF2, KIT, KITLG, NBN, MYCN
28	pigmentation phenotype	MP:0001186	INF	, KIT, KITLG, RB1, SERPINF1, SEMA4A
29	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRP1, , NDN, NCOA1, NCOA2

Articles related to hypoxia:

(show top 50)    (show all 3777)

id	Title	Authors	Year	Affiliating Genes
1	Hypoxia induces tumor aggressiveness and the expansio n of CD133-positive cells in a hypoxia-inducible factor-1I+-dependent manner in pancreatic cancer cells. (21778785)	Hashimoto O.... Hori Y.	2011	HIF1A, PROM1
2	Hypoxia stimulates low-density lipoprotein receptor-r elated protein-1 expression through hypoxia-inducible factor-1I+ in human vascul ar smooth muscle cells. (21454812)	Castellano J.... Llorente-CortAcs V.	2011	LRP1, HIF1A
3	Dihydrotestosterone attenuates hypoxia inducible fact or-1I+ and cyclooxygenase-2 in cerebral arteries during hypoxia or hypoxia with glucose deprivation. (21856910)	Zuloaga K.L.... Gonzales R.J.	2011	PTGS2, HIF1A
4	Hypoxia induced paclitaxel resistance in human ovaria n cancers via hypoxia-inducible factor 1alpha. (19760195)	Huang L.... Ma D.	2010	HIF1A
5	The hypoxia-inducible factor 1/NOR-1 axis regulates t he survival response of endothelial cells to hypoxia. (19720740)	Martorell L.... MartA-nez-GonzA!lez J.	2009	HIF1A, NR4A3
6	Hypoxia-inducible factor 1alpha inhibits the fibrobla st-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. (19790048)	Duval E.... BoumAcdiene K.	2009	HIF1A, COL1A2, COL3A1
7	Hypoxia-induced downregulation of autophagy mediator Beclin 1 reduces the susceptibility of malignant intestinal epithelial cells to hypoxia-dependent apoptosis. (19901551)	Yoo B.H.... Rosen K.	2009	BECN1
8	Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. (19122655)	Rosenberger P.... Eltzschig H.K.	2009	NTN1
9	Hypoxia. Hypoxia in the pathogenesis of systemic scle rosis. (19473554)	Beyer C.... Distler J.H.	2009	VEGFA
10	Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia . (19699082)	Hoogsteen I.J.... Kaanders J.H.	2009	CA9
11	Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhib iting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. (19456861)	Shin D.H.... Park J.W.	2009	NFKBIA, HIF1A
12	Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing. (19076725)	HernA!ndez C.... Barrachina M.D.	2009	TFF1, TFF2
13	Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se. (19007879)	Millonig G.... Mueller S.	2009	HIF1A, SETD2
14	Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells. (18447926)	Malhotra R.... Brosius F.C.	2008	HIF1A
15	Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). (18339685)	Han Z.B.... Han Z.C.	2008	HIF1A, KITLG
16	Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. (18172309)	Glunde K.... Bhujwalla Z.M.	2008	HIF1A, CHKA
17	Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma b y targeting hypoxia-inducible factor-1alpha and -2alpha. (18645007)	Puppo M.... Bosco M.C.	2008	VEGFA, HIF1A
18	Hypoxia-induced IL-18 increases hypoxia-inducible factor-1alpha expression through a Rac1-dependent NF-kappaB pathway. (18003981)	Kim J.... Choi I.	2008	HIF1A, IL18, IL18RAP
19	Down-regulation of vascular endothelial growth factor in human retinal pigment epithelial cells by small hairpin loop RNA targeting hypoxia inducible factor-1 alpha under hypoxia condition (18307947)	Xiao Q.... Kuang W.H.	2007	VEGFA, HIF1A
20	Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression. (17673462)	Echevarria M.... Lopez-Barneo J.	2007	AQP1
21	Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. (17555795)	Osada R.... Konishi I.	2007	HIF1A, VHL, EPAS1
22	Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. (17635920)	Nguyen A.D.... DeBose-Boyd R.A.	2007	HMGCR
23	Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. (17483326)	Hiraga T.... Yoneda T.	2007	SETD2, TOP3A
24	Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. (17474992)	Mojsilovic-Petrovic J.... Zhang W.	2007	HIF1A, SETD2
25	Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia. (17608772)	Lee J.W.... Kim K.W.	2007	PRKCD
26	Exercise training in normobaric hypoxia: is carbonic anhydrase III the best marker of hypoxia? (17666736)	Padilla J.... Mickleborough T.D.	2007	CA3
27	Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. (17283112)	Dewhirst M.W.	2007	SETD2
28	Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level. (16882692)	Hubert A.... Michiels C.	2006	HIF1A, SETD2
29	Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis. (17145871)	Tanaka H.... Ogawa K.	2006	PIK3CG, HIF1A, SETD2
30	Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof (16854277)	Zhang N.... Na Y.Q.	2006	VEGFA, HIF1A
31	Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. (17040902)	Baird N.A.... Johnson E.A.	2006	IL6, SETD2
32	Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. (15994306)	Bilton R.... Brahimi-Horn M.C.	2005	HIF1A, BLZF1, NAA10
33	Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene. (15669079)	Menendez J.A.... Lupu R.	2005	ERBB2, FASN, VEGFA
34	Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells. (16024111)	Said H.M.... Vordermark D.	2005	SPP1
35	Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer. (16251878)	Van den Eynden G.G.... Van Marck E.A.	2005	HIF1A, CA9
36	Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines. (16032459)	Takabuchi S.... Fukuda K.	2005	OPRK1
37	Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. (16198981)	Overgaard J.... Horsman M.R.	2005	SPP1
38	Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. (15930314)	Chau N.M.... Ashcroft M.	2005	HIF1A, SETD2
39	Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins. (15611046)	McMahon S.... Dubois C.M.	2005	FURIN, HIF1A
40	Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. (15994966)	Detwiller K.Y.... Yoon S.S.	2005	GTF3A
41	From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. (12207089)	Ratcliffe P.J.	2002	HIF1A, EPO
42	Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. (12154057)	Kaluz S.... Stanbridge E.J.	2002	HIF1A, CA9, SETD2
43	l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblasts. (11884212)	Bharadwaj L.A.... Ovsenek N.	2002	SETD2
44	Induction of hypoxia-inducible factor-1alpha and activation of caspase-3 in hypoxia-reoxygenated bone marrow stroma is negatively regulated by the delayed production of substance P. (11591789)	Qian J.... Rameshwar P.	2001	TAC1
45	Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis. (11417843)	Chae H.J.... Kim H.R.	2001	CASP3, CASP6
46	Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication. (10763583)	Zhang Y.W.... Murota S.	2000	SOD1, PTK2B
47	Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. (10607702)	Kimura H.... Esumi H.	2000	JUN, HIF1A, SETD2
48	Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. (11156418)	Blancher C.... Harris A.L.	2000	LDHA, HIF1A
49	Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. (8338939)	Beck I.... Caro J.	1993	EPO
50	Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. (1279431)	Shweiki D.... Keshet E.	1992	VEGFA

Genes related to hypoxia according to GeneCards:

(show top 50)    (show all 1515)

id	Symbol	Description	Score	GeneCards Section Context
1	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.1	Publications, Functions, Summaries, Expressions (show all 9 sections) Transcripts, Pathways & Interactions, Aliases & Descriptions, Domains & Families, Orthologs
2	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	11.1	Publications, Summaries, Aliases & Descriptions, Functions
3	HIF3A	hypoxia inducible factor 3, alpha subunit	11.1	Functions, Publications, Summaries, Transcripts (show all 8 sections) Pathways & Interactions, Aliases & Descriptions, Proteins, Orthologs
4	HYOU1	hypoxia up-regulated 1	11.1	Transcripts, Publications, Aliases & Descriptions, Pathways & Interactions (show all 8 sections) Functions, Proteins, Orthologs, Summaries
5	EGLN2	egl nine homolog 2 (C. elegans)	11.1	Publications, Functions, Pathways & Interactions, Aliases & Descriptions (show all 6 sections) Orthologs, Summaries
6	ARNT	aryl hydrocarbon receptor nuclear translocator	11.1	Publications, Pathways & Interactions, Aliases & Descriptions, Functions (show all 6 sections) Orthologs, Summaries
7	EGLN1	egl nine homolog 1 (C. elegans)	11.1	Publications, Functions, Pathways & Interactions, Aliases & Descriptions (show all 6 sections) Orthologs, Summaries
8	HILPDA	hypoxia inducible lipid droplet-associated	11.0	Publications, Transcripts, Aliases & Descriptions, Functions (show all 6 sections) Proteins, Orthologs
9	CA9	carbonic anhydrase IX	11.0	Publications, Summaries, Pathways & Interactions, Functions
10	CA12	carbonic anhydrase XII	11.0	Summaries, Publications
11	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	11.0	Summaries, Publications, Pathways & Interactions, Orthologs
12	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	11.0	Summaries, Publications
13	CA2	carbonic anhydrase II	11.0	Summaries, Publications
14	CA4	carbonic anhydrase IV	11.0	Summaries, Publications
15	EP300	E1A binding protein p300	11.0	Publications, Summaries, Pathways & Interactions
16	RGS5	regulator of G-protein signaling 5	11.0	Summaries, Publications
17	HIGD1AP1	HIG1 hypoxia inducible domain family, member 1A pseudogene 1	11.0	Aliases & Descriptions
18	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	11.0	Publications, Functions, Transcripts, Pathways & Interactions (show all 6 sections) Aliases & Descriptions, Orthologs
19	HIGD1A	HIG1 hypoxia inducible domain family, member 1A	11.0	Transcripts, Pathways & Interactions, Aliases & Descriptions, Domains & Families (show all 6 sections) Functions, Orthologs
20	EPAS1	endothelial PAS domain protein 1	11.0	Publications, Pathways & Interactions, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
21	HIGD2B	HIG1 hypoxia inducible domain family, member 2B	11.0	Transcripts, Aliases & Descriptions, Domains & Families, Orthologs
22	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications, Pathways & Interactions, Functions, Summaries
23	SIAH2	siah E3 ubiquitin protein ligase 2	11.0	Publications, Summaries
24	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	11.0	Publications, Pathways & Interactions, Functions, Proteins (show all 5 sections) Summaries
25	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	11.0	Publications, Functions, Summaries
26	SIAH1	siah E3 ubiquitin protein ligase 1	11.0	Publications, Summaries
27	WDR83	WD repeat domain 83	11.0	Publications, Functions, Summaries
28	OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	11.0	Publications, Summaries
29	UGDH	UDP-glucose 6-dehydrogenase	11.0	Publications, Summaries
30	CHRDL1	chordin-like 1	11.0	Publications, Functions, Summaries
31	TP53	tumor protein p53	11.0	Publications, Pathways & Interactions, Summaries
32	CHEK1	checkpoint kinase 1	11.0	Publications, Summaries
33	CHEK2	checkpoint kinase 2	11.0	Publications, Summaries
34	HIF1AP1	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) pseudogene 1	11.0	Aliases & Descriptions
35	HIGD1AP17	HIG1 hypoxia inducible domain family, member 1A pseudogene 17	11.0	Aliases & Descriptions
36	LOC100289360	HIG1 hypoxia inducible domain family, member 2A pseudogene	11.0	Aliases & Descriptions
37	HIGD1AP10	HIG1 hypoxia inducible domain family, member 1A pseudogene 10	11.0	Aliases & Descriptions
38	HIGD1AP11	HIG1 hypoxia inducible domain family, member 1A pseudogene 11	11.0	Aliases & Descriptions
39	HIGD1AP12	HIG1 hypoxia inducible domain family, member 1A pseudogene 12	11.0	Aliases & Descriptions
40	HIGD1AP13	HIG1 hypoxia inducible domain family, member 1A pseudogene 13	11.0	Aliases & Descriptions
41	HIGD1AP14	HIG1 hypoxia inducible domain family, member 1A pseudogene 14	11.0	Aliases & Descriptions
42	HIGD1AP15	HIG1 hypoxia inducible domain family, member 1A pseudogene 15	11.0	Aliases & Descriptions
43	HIGD1AP16	HIG1 hypoxia inducible domain family, member 1A pseudogene 16	11.0	Aliases & Descriptions
44	HIGD1AP18	HIG1 hypoxia inducible domain family, member 1A pseudogene 18	11.0	Aliases & Descriptions
45	HIGD1AP2	HIG1 hypoxia inducible domain family, member 1A pseudogene 2	11.0	Aliases & Descriptions
46	HIGD1AP3	HIG1 hypoxia inducible domain family, member 1A pseudogene 3	11.0	Aliases & Descriptions
47	HIGD1AP4	HIG1 hypoxia inducible domain family, member 1A pseudogene 4	11.0	Aliases & Descriptions
48	HIGD1AP5	HIG1 hypoxia inducible domain family, member 1A pseudogene 5	11.0	Aliases & Descriptions
49	HIGD1AP6	HIG1 hypoxia inducible domain family, member 1A pseudogene 6	11.0	Aliases & Descriptions
50	HIGD1AP7	HIG1 hypoxia inducible domain family, member 1A pseudogene 7	11.0	Aliases & Descriptions

Pathways related to hypoxia according to GeneDecks:

(show top 50)    (show all 363)

id	Pathway	Score	Top Affiliating Genes
1	WNT Signaling36	INF	ZNF354A, , BTRC, MYC, RAC1, BIRC5
2	MAPK Signaling36	28.6	ZNF354A, PIK3R1, KIT, KITLG, BRAF, VEGFB
3	Akt Signaling36	25.7	PIK3R1, PIK3CG, KIT, VEGFB, VEGFC, BMP2
4	Renin-Angiotensin Pathway36	22.3	PIK3R1, REN, KIT, KITLG, VEGFB, VEGFC
5	STAT3 Pathway36	21.6	PIM1, BRAF, MYC, BMP2, BMP4, BMP6
6	Apoptosis and Autophagy3	20.5	PIM1, PDCD4, SERPINB5, LMNA, BNIP3L, MYC
7	Glucocorticoid Receptor Signaling36	20.5	NCOA1, BMP2, BMP4, BMP6, BMP7, BCL2
8	Activation of PKC through GPCR36	19.9	PIK3R1, KIT, KITLG, VEGFB, VEGFC, BMP2
9	Glucose / Energy Metabolism3	19.7	PCK2, LPIN1, SCD, LDHA, CEBPB, CEBPA
10	NF-KappaB Family Pathway36	19.2	PIK3R1, RELA, KITLG, VEGFB, VEGFC, BMP2
11	Influenza A20	19.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
12	Rap1 Pathway36	18.3	KITLG, BRAF, VEGFB, VEGFC, BMP2, BMP4
13	TGF-beta Signaling Pathways37	18.1	PIK3CB, PIK3CD, PIK3R1, PIK3CG, RELA, BRAF
14	Regulation of eIF4 and p70S6K36	17.6	PIK3R1, VEGFC, BMP2, BMP4, BAX, ITGA2
15	Tuberculosis20	17.6	RELA, RAF1, BID, BCL2, BAD, BAX
16	Apoptosis20	17.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
17	HIF1Alpha Pathway36	17.3	NCOA1, RBX1, VHL, VEGFB, VEGFC, LDHA
18	Development_IGF-1 receptor signaling41	17.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, MYC
19	AMPK Enzyme Complex Pathway36	16.8	PIK3R1, LEP, CFTR, GYS1, IRS1, IRS2
20	Measles20	16.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
21	NFAT and Cardiac Hypertrophy36	16.3	PIK3R1, RAF1, LIF, ITPR1, ITPR2, GSK3B
22	VEGF signaling pathway20	16.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, VEGFA
23	VEGF Signaling Pathway34	15.4	PIGF, PIK3C2A, VEGFA, VEGFB, VEGFC, RAF1
24	mTOR signaling pathway20	15.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, BRAF
25	Immune response_IL-2 activation and signaling pathway41	15.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, MYC
26	HGF Pathway36	15.3	PIK3R1, RB1, RAF1, RAC1, PAK1, JUN
27	GnRH signaling pathway20	15.2	RAF1, CGA, ATF4, JUN, CDC42, ITPR1
28	Cell adhesion ECM remodeling10	15.2	VTN, SERPINE1, SDC2, LAMA3, LAMA4, ITGA5
29	HMGB1 Pathway36	14.8	PIK3R1, RAC1, JUN, CDC42, FOS, IL1A
30	Immune response_IFN gamma signaling pathway41	14.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, BRCA1, MYC
31	Adipocytokine signaling pathway20	14.8	RELA, PCK2, LEP, LEPR, CHUK, MTOR
32	Immune response Fc epsilon RI pathway10	14.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, RAF1
33	Development_Leptin signaling via PI3K-dependent pathway41	14.7	PIK3CB, PIK3CD, PIK3R1, RELA, KCNJ11, LEP
34	Development_VEGF signaling and activation41	14.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, SELE
35	Development FGFR signaling pathway10	14.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, RAF1, RAC1
36	Epithelial cell signaling in Helicobacter pylori infection20	14.5	RELA, RAC1, PAK1, CHUK, JUN, CDC42
37	PKR Pathway36	14.5	RELA, CHUK, ATF2, JUN, FOS, MAPK8
38	Development VEGF-family signaling10	14.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, VTN, VEGFB
39	Translation_Insulin regulation of translation41	14.4	PIK3CB, PIK3CD, PIK3R1, RAF1, MTOR, IRS1
40	ErbB Family Pathway36	14.3	PIK3R1, BRAF, RAF1, PAK1, JUN, CDC42
41	Immune response_Oncostatin M signaling via MAPK in human cells41	13.9	RAF1, RAC1, CEBPB, ATF2, JUN, JUNB
42	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	13.8	PIK3CB, PIK3CA, PIK3R1, NCOA2, MYOD1, KAT2B
43	ErbB2-ErbB3 Heterodimers36	13.5	PIK3R1, RAF1, BAD, ITPR1, ITPR2, FOXO3
44	UVC-Induced MAPK Signaling36	13.5	BRAF, RAF1, ATR, JUN, FOS, MAPK8
45	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	13.4	BRAF, RAF1, RAC1, PAK1, CEBPB, ATF2
46	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways37	13.4	PIK3CB, PIK3CD, PIK3R1, PIK3CG, BRAF, RAF1
47	Transcription PPAR Pathway10	12.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, NCOA1, RAF1
48	Signal transduction AKT signaling10	12.2	PIK3CB, PIK3CD, PIK3R1, GYS1, IRS1, GSK3A
49	Translational Control3	INF	PDCD4, LPIN1, ZFP36L1, KHSRP, KEAP1, YY1
50	Pathways in cancer20	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3CG

Compounds related to hypoxia according to GeneDecks:

(show top 50)    (show all 476)

id	Compound	Score	Top Affiliating Genes
1	serine32	85.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIM1
2	oxygen32 18	63.0	PIGF, PIK3C2A, KITLG, SFTPB, SFTPC, RB1
3	superoxide32 18	43.6	PIK3CA, PIK3R1, PIK3C2A, PDE4A, KITLG, PC
4	lactate32	39.6	PIK3CA, PIK3C2A, RECK, KIT, KITLG, VWF
5	matrigel32	30.5	PIGF, PIK3CA, PIK3R1, PIK3CG, LRP1, VWF
6	norepinephrine32 9 18 9	31.6	PIK3C2A, PDE4A, REN, KITLG, VWF, SELE
7	aspartate32	28.4	PIK3R1, PIK3C2A, RET, VTN, PC, PCK2
8	ascorbic acid32 18	28.8	PIK3CG, SFTPB, PCNA, SETD2, BMP2, BMP4
9	fibrinogen32	22.2	PIK3CB, PIK3C2A, RECK, VTN, SFTPB, SFTPC
10	agar32	21.0	PIK3CA, PIK3R1, RET, KITLG, RB1, BRAF
11	cytochalasin d32 42	21.5	PIK3CG, KITLG, VWF, VTN, SELE, SELL
12	carbon32	20.3	VWF, VTN, PC, PCNA, SCD, UCP1
13	polyacrylamide32	20.3	RECK, SFTPB, PC, RB1, SERPINA1, BRCA1
14	polysaccharide32	20.0	RECK, KITLG, VTN, SELE, SELL, SELP
15	docetaxel32 34 9 9	20.7	KIT, SETD2, BRCA1, VEGFA, MYC, RAF1
16	manganese superoxide32	17.3	SFTPB, VCAM1, BCL2L1, UCP1, UCP2, XRCC1
17	rotenone32	16.8	PIK3CG, PARP1, PARK7, PARK2, BCL2, BCL2L1
18	hydroxyurea32 9 9	18.7	KIT, KITLG, PCNA, NBN, SELL, BRCA1
19	mitomycin c32	16.6	VWF, PCK2, PCNA, RB1, NBN, BRCA1
20	vitamin a32 9 18 9	19.5	RET, VWF, SFTPB, PCK2, RB1, SERPINA1
21	guanylate32	16.0	PIK3CB, SETD2, SERPINF1, VIP, BRCA1, VASP
22	verapamil32 34 9 18 9	19.9	LRP1, RECK, REN, VIP, MYC, UTS2
23	daunorubicin32 9 9	17.7	RELA, KITLG, MYC, RAF1, BIRC5, BCL2
24	prednisolone32 9 9	17.6	PIK3C2A, KITLG, VWF, SELL, VIP, VCAM1
25	c2ceramide32	15.5	PIK3CG, BECN1, PARP1, BCL2L1, CHUK, UGCG
26	leukotriene b432 42 18	17.5	PDE4A, SELL, SELP, RAC1, MPO, ITGAM
27	thromboxane a232 18	16.3	PIK3C2A, PDE4A, VWF, SELP, LIF, BDKRB2
28	amide32	15.0	PAM, KCNH2, CHGA, BACE1, MT2A, ITGA2
29	capsaicin32	14.9	SELE, VIP, BDNF, SCG2, LEP, S100A12
30	progestin32	14.8	PIK3R1, VEGFA, LIF, KDR, LHCGR, CGA
31	2-deoxyglucose32	14.5	PIK3R1, PIK3CG, BAIAP2L1, XBP1, FOS, IRS1
32	chloroquine32 34 9 9	17.5	KIT, VTN, BRCA1, BMP6, RAF1, KCNH2
33	glucosamine32 9 18 9	17.4	SELL, CD36, MMP13, MMP3, IRS1, IRS2
34	methylmethanesulfonate32	14.3	PCNA, NBN, BRCA1, RAD51, PARP1, CHEK1
35	opiate32	14.3	CHRM2, CGA, MME, GUSB, APP, FAS
36	tpck32	14.2	PIK3CG, PARP1, BCL2L1, BAK1, JUN, IL1B
37	tetrapeptide32	14.2	VTN, RB1, BIRC5, BCL2L1, LCK, XIAP
38	acetaminophen32 34 9 18 9	18.0	PCNA, MYC, BCL2L1, SDHB, MMP3, GSS
39	ndga32	14.0	VCAM1, JUN, MMP13, MMP3, FOS, IL1B
40	ibuprofen32 9 18 9	16.8	VCAM1, BMP6, BDNF, LEP, CHUK, BACE1
41	cobalt chloride32	13.6	PIK3CG, SELE, SETD2, VHL, VEGFA, VCAM1
42	thiazolidinedione32	13.3	PCK2, SERPINE1, LEP, UCP1, UCP2, UCP3
43	tarc32	13.0	CDH1, IL10, IL13, IL18, IL1A, IL4
44	octreotide32 42 9 9	15.9	VIP, VEGFA, UTS2, CHGA, MPO, MME
45	fluticasone propionate32 42 9 9	15.0	SELE, VCAM1, BGLAP, MPO, MMP9, IL13
46	vitamin d32	INF	LRP1, , NCOA1, NCOA2, SERPINE1, BMP2
47	dopamine32 9 18 9	INF	PIK3CA, PDE4A, REN, RET, SELE, VIP
48	estrogen32	INF	PIK3CB, PIK3R1, , KLF5, NCOA1, NCOA2
49	rapamycin32 42	INF	PIK3CG, PIM1, KIT, KITLG, PCK2, RB1
50	tyrosine32	INF	PIK3CB, PIK3CD, PIGF, PIK3CA, PIK3R1, PIAS4

Cellular components related to hypoxia according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	INF	LRP1, RET, SELL, SELP, SEMA4D, BMPR2
2	cytosol	GO:005829	61.5	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
3	extracellular region	GO:005576	39.4	RETNLB, KITLG, VWCE, VWF, VTN, SFTPA1
4	nucleoplasm	GO:005654	35.3	ZNF217, NCOA1, NCOA2, RELA, PCNA, RB1
5	mitochondrion	GO:005739	30.4	PC, PCK2, BSG, VHL, VDAC2, BOK
6	perinuclear region of cytoplasm	GO:048471	20.9	KLHL20, PDE4A, SELE, SEPT9, VLDLR, LMNA
7	transcription factor complex	GO:005667	17.1	RELA, GCM1, MYOD1, USF1, CLOCK, PARP1
8	neuronal cell body	GO:043025	17.0	NCOA2, BMPR2, SDC2, CHRM2, CHAT, CHRNA4
9	protein complex	GO:043234	16.1	BRCA1, MYC, BMP2, USP28, BECN1, PAK1
10	membrane raft	GO:045121	14.9	SELE, BSG, LCK, P2RX3, FURIN, CD24
11	external side of plasma membrane	GO:009897	14.9	KIT, VWF, SELL, SELP, VCAM1, KDR
12	mitochondrial outer membrane	GO:005741	14.8	VDAC2, BNIP3, BNIP3L, BMF, RAF1, BID
13	platelet alpha granule lumen	GO:031093	13.8	VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC
14	caveola	GO:005901	12.8	SELE, BMPR2, KCNA5, KCNMA1, ATP1B1, MLC1
15	cytoplasm	GO:005737	INF	PIAS4, PIP5KL1, PIK3C2A, PIK3CG, PIM1, WDR26
16	membrane	GO:016020	INF	PIP5KL1, PIK3CG, PDE4A, RECK, REN, SELENBP1
17	cell surface	GO:009986	INF	KLHL20, SFRP1, VLDLR, VEGFA, VCAM1, BMP2
18	nucleus	GO:005634	INF	ZNF354A, ZNF195, PIK3CB, PIAS4, PIK3C2A, PIM1
19	extracellular space	GO:005615	INF	REN, KIT, KITLG, VTN, SFRP1, SFTPA1
20	plasma membrane	GO:005886	INF	PIK3CD, PIK3R1, PIK3C2A, PIK3CG, PIM1,

Biological processes related to hypoxia according to GeneDecks:

(show top 50)    (show all 91)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	40.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
2	response to hypoxia	GO:001666	31.8	SFTPB, SERPINA1, NARFL, VEGFA, VCAM1, BNIP3
3	response to drug	GO:042493	26.6	PDE4A, REN, SFRP1, NBN, VLDLR, VEGFC
4	gene expression	GO:010467	22.1	WARS, SERPINE1, MYC, RARA, ZFP36, ZFP36L1
5	negative regulation of transcription, DNA-dependent	GO:045892	21.0	ZNF217, PIAS4, PDCD4, RELA, SFRP1, BTRC
6	cellular response to hypoxia	GO:071456	20.0	RGCC, SFRP1, RBX1, VLDLR, VHL, VEGFA
7	innate immune response	GO:045087	19.4	PIK3CD, PIK3CG, RELA, CLU, BCL2, BCL2L1
8	axon guidance	GO:007411	19.0	SEMA4D, SEMA3F, SEMA4A, VASP, RAF1, RAC1
9	positive regulation of angiogenesis	GO:045766	17.3	SERPINE1, VEGFA, RAMP2, UTS2, UTS2R, KDR
10	glucose metabolic process	GO:006006	17.2	PIK3CA, PC, PCK2, MYC, USF1, KCNJ11
11	heart development	GO:007507	17.2	PCNA, VLDLR, VCAM1, BMP2, RAMP2, RAF1
12	insulin receptor signaling pathway	GO:008286	17.0	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, NAMPT, RAF1
13	epidermal growth factor receptor signaling pathway	GO:007173	16.9	PIK3CA, PIK3R1, PIK3C2A, KIF16B, RAF1, CHUK
14	transforming growth factor beta receptor signaling pathway	GO:007179	16.8	SERPINE1, MYC, PARP1, CITED2, UBA52, UBB
15	aging	GO:007568	16.8	SERPINF1, VCAM1, SCAP, UCP3, BAK1, FURIN
16	response to lipopolysaccharide	GO:032496	16.8	SFTPB, SFTPC, SELE, SELP, SERPINA1, KCNJ8
17	cell cycle arrest	GO:007050	16.7	RB1, NBN, SESN2, MYC, SART1, MSH2
18	fibroblast growth factor receptor signaling pathway	GO:008543	16.6	PIK3CA, PIK3R1, KIF16B, BRAF, RAF1, CHUK
19	response to estradiol stimulus	GO:032355	16.5	NCOA1, SERPINA1, BMP4, RARA, BID, PAM
20	transcription initiation from RNA polymerase II promoter	GO:006367	16.4	SERPINE1, MYC, RARA, PARP1, UBA52, UBB
21	positive regulation of protein phosphorylation	GO:001934	15.9	SEMA4D, VEGFA, BMP2, BMP4, MT3, MTOR
22	Notch signaling pathway	GO:007219	15.9	RBX1, SEL1L, MYC, BMP2, UBA52, UBB
23	protein autophosphorylation	GO:046777	15.8	PIM1, KIT, VRK2, PAK1, KDR, CHEK2
24	induction of apoptosis by intracellular signals	GO:008629	15.8	BNIP3, MYC, BMF, BID, CLU, BCL2
25	response to ethanol	GO:045471	15.8	BGLAP, BCL2, CHAT, CHRNB2, LCT, BAK1
26	positive regulation of gene expression	GO:010628	15.7	KIT, BRAF, VEGFA, BMP2, RAMP2, CITED2
27	negative regulation of neuron apoptotic process	GO:043524	15.7	BRAF, VEGFB, PARK7, PARK2, BDNF, BCL2
28	regulation of cell proliferation	GO:042127	15.6	KIT, SERPINE1, BRCA1, BMPR2, BID, BIRC6
29	positive regulation of endothelial cell proliferation	GO:001938	15.6	VEGFA, VEGFB, BMP2, BMP4, BMP6, BMPR2
30	response to glucose stimulus	GO:009749	15.5	SFTPB, SFTPC, UCN3, IRS2, ARG2, INSR
31	platelet degranulation	GO:002576	14.7	VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFB
32	toll-like receptor 3 signaling pathway	GO:034138	14.6	RELA, CHUK, UBA52, UBB, UBC, ATF2
33	positive regulation of ERK1 and ERK2 cascade	GO:070374	14.6	BRAF, VEGFB, BMP2, BMP4, KDR, MT3
34	toll-like receptor signaling pathway	GO:002224	14.6	RELA, CHUK, UBA52, UBB, UBC, ATF2
35	toll-like receptor 2 signaling pathway	GO:034134	14.6	RELA, CHUK, UBA52, UBB, UBC, ATF2
36	cellular response to stress	GO:033554	14.5	RBX1, VHL, VEGFA, PAK1, UBA52, UBB
37	toll-like receptor 4 signaling pathway	GO:034142	14.5	RELA, CHUK, UBA52, UBB, UBC, ATF2
38	MyD88-dependent toll-like receptor signaling pathway	GO:002755	14.5	RELA, CHUK, UBA52, UBB, UBC, ATF2
39	cellular response to mechanical stimulus	GO:071260	14.5	SFTPB, SFTPC, BNIP3, CHEK1, BAD, BAK1
40	TRIF-dependent toll-like receptor signaling pathway	GO:035666	14.4	RELA, CHUK, UBA52, UBB, UBC, ATF2
41	MyD88-independent toll-like receptor signaling pathway	GO:002756	14.4	RELA, CHUK, UBA52, UBB, UBC, ATF2
42	activation of pro-apoptotic gene products	GO:008633	14.4	MYC, BMF, BID, BCL2, BCL2L11, BBC3
43	toll-like receptor 1 signaling pathway	GO:034130	14.4	RELA, CHUK, UBA52, UBB, UBC, ATF2
44	positive regulation of protein kinase B signaling cascade	GO:051897	14.3	PIK3CG, VEGFB, MTDH, MTOR, MST1R, INS
45	response to wounding	GO:009611	14.0	VWF, RAC1, ITGB4, FN1, FGF7, MET
46	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	13.9	RBX1, VHL, VEGFA, UBA52, UBB, UBE2D3
47	cell-cell signaling	GO:007267	INF	NAMPT, BMP2, CGA, ITGB2, AR, INHBA
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, KLF2, NCOA1, NCOA2, RELA, RB1
49	positive regulation of transcription, DNA-dependent	GO:045893	INF	, KLF1, KLF2, KLF5, NCOA1, RELA
50	signal transduction	GO:007165	INF	PIK3CB, PIK3CD, PDE4A, RET, KIT, KITLG

Molecular functions related to hypoxia according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	INF	KIT, VWF, SFTPC, VEGFA, VEGFB, BNIP3
2	ATP binding	GO:005524	36.2	PIK3CB, PIK3CD, PIK3CA, PIP5KL1, PIK3C2A, PIK3CG
3	sequence-specific DNA binding transcription factor activity	GO:003700	29.0	ZNF217, KLF1, KLF16, KLF2, KLF5, RELA
4	sequence-specific DNA binding	GO:043565	22.0	KLF2, NANOG, MYC, RARA, USF2, USF1
5	identical protein binding	GO:042802	20.6	RELA, SFRP1, PCNA, BNIP3, BNIP3L, RAD51
6	transcription factor binding	GO:008134	20.5	PIM1, RELA, GCM1, RB1, NBN, VHL
7	receptor binding	GO:005102	19.9	REN, SEMA4D, SERPINE1, BMP2, RARA, UTS2
8	protein kinase binding	GO:019901	19.5	RGCC, RELA, USF1, ZFP36, PAK1, PARK2
9	enzyme binding	GO:019899	18.3	NCOA1, BRCA1, VHL, RARA, RAC1, USF1
10	protein kinase activity	GO:004672	16.6	PIK3CG, BRAF, RAF1, PAK1, CHUK, AURKA
11	iron ion binding	GO:005506	16.2	KDM3A, SDHD, SCD, P4HA1, P4HA2, P4HA3
12	heparin binding	GO:008201	15.3	VTN, SFRP1, SELL, SELP, VEGFA, VEGFB
13	hormone activity	GO:005179	14.7	RETNLB, VIP, UTS2, LEP, UCN2, UCN3
14	protein binding	GO:005515	INF	ZNF217, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4
15	ubiquitin protein ligase binding	GO:031625	INF	PIAS4, RELA, RB1, RBX1, BRCA1, MYOD1
16	cytokine activity	GO:005125	INF	KITLG, NAMPT, VEGFA, BMP2, BMP4, BMP6
17	growth factor activity	GO:008083	INF	KITLG, VEGFA, VEGFB, VEGFC, BMP2, BMP4
18	protein heterodimerization activity	GO:046982	INF	BRAF, VEGFA, VEGFB, BOK, BNIP3, BNIP3L