Ichthyosis malady

Wikipedia: Ichthyosis (plural Ichthyoses) is a heterogeneous family of at least 28, generalized, mostly genetic...⁴⁴ more...

MalaCards: Ichthyosis, also known as congenital ichthyosis, is related to x-linked ichthyosis and ichthyosis vulgaris. An important gene associated with Ichthyosis is TGM1 (transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeleton remodeling_Keratin filaments. The compounds collodion and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney, and related mouse phenotypes are craniofacial and pigmentation.

ichthyosis 7 17 32 congenital ichthyosis 43

Diseases related to ichthyosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 242)

id	Related Disease	Score	Top Affiliating Genes
1	x-linked ichthyosis	35.9	VCX3A, FLG, ARSH, TGM1, STS
2	ichthyosis vulgaris	34.7	CDSN, IVL, FLG2, FLG, LOR, SPRR1B
3	ichthyosis bullosa of siemens	34.2	KRT1, KRT10, KRT2, CSTA
4	autosomal recessive congenital ichthyosis	34.0	LIPN, LI5, INLNE, ALOX12B, ALOX15B, ALOXE3
5	harlequin type ichthyosis	33.9	FLG, DUSP19, ABCA12, TGM1, CST6
6	congenital ichthyosiform erythroderma	33.9	LOR, ALOX12B, ALOXE3, SPINK5, TGM1
7	ichthyosis with hypotrichosis	31.8	TMPRSS11A, ST14, PRSS8
8	ichthyosis prematurity syndrome	31.8	ICR4, SLC27A4, SLC27A1
9	kid syndrome	31.2	GJB2, GJB3, GJB6
10	atopic dermatitis	31.1	LBR, CDSN, IVL, FLG, LOR, SPINK5
11	ichthyosis, follicular	30.9	FLG, TMPRSS11A, ST14, PRSS8
12	hypotrichosis	30.9	CLDN1, CDSN, FLG, GJB2, GJB3, TMPRSS11A
13	exfoliative ichthyosis	30.8	RARG, ITGB7, IGFBP6, KRT5, KRT2, CSTA
14	netherton syndrome	30.6	CDSN, FLG, SPINK5, TGM1, TGM3, GBA
15	epidermolytic hyperkeratosis	30.0	FLG, KRT5, KRT1, KRT10
16	kallmann syndrome	30.0	VCX, VCX2, VCX3A, VCX3B, XG, CGA
17	dermatitis	29.4	RELA, CLDN1, LBR, KAL1, CDSN, IVL
18	keratoderma	29.4	RARG, LELP1, FLG, LOR, ALOX12B, ALOXE3
19	alopecia	29.3	CLDN1, FLG, MBTPS2, CYP4F22, KRT16, KRT86
20	skin disease	28.8	GJB3, KRT1, KRT10, KRT9, TGM1
21	ocular albinism	28.5	VCX, VCX2, VCX3A, VCX3B, XG, XGPY2
22	albinism	28.4	VCX3A, XGPY2, KAL1, ARSH, ARSE, GPR143
23	photosensitive trichothiodystrophy	28.3	GTF2H5, ERCC2, ERCC3
24	chondrodysplasia punctata	28.2	XG, ARSH, ARSE, ARSA, ARSB, GPR143
25	chondrodysplasia	28.2	XG, ARSH, ARSE, ARSA, ARSB, GPR143
26	ectropion	27.9	MBTPS2, CYP4F22, ABCA12, ABHD5, TGM1
27	vohwinkel syndrome	27.8	LOR, GJB2, KRT10, TGM1
28	erythrokeratoderma	27.6	LOR, GJB3, KRT10, ABHD5
29	epidermolytic palmoplantar keratoderma	27.5	KRT16, KRT17, KRT1, KRT9
30	anosmia	27.1	XG, KAL1, PHYH, PEX7
31	ectodermal dysplasia	26.9	GJB2, GJB3, GJB6, KRT16, KRT17, KRT14
32	spasticity	26.1	ARSA, ALDH3A2, CAPN1, NIPA1, NIPA2, NIPAL1
33	short stature	25.0	BRAF, ARSE, ARSB, MAP2K2, MAP2K1, ALDH3A2
34	psoriasis	24.6	SERPINB2, CLDN1, LELP1, CDSN, IVL, FLG2
35	cholesterol	23.0	RELA, SERPINA7, RARG, LIPN, CLDN1, LBR
36	carcinoma	16.6	RELA, VPS37A, SERPINA7, SERPINB2, BRAF, RARG
37	glucocorticoid deficiency	13.9	IVL, FLG, LOR, STS
38	acanthoma	13.9	IVL, KRT16, KRT1, KRT10
39	epidermolytic acanthoma	13.9	KRT16, KRT1, KRT10
40	bowen syndrome	13.9	IVL, FLG, KRT16, KRT17, KRT1, KRT10
41	molluscum contagiosum	13.9	IVL, FLG, LOR, KRT16, KRT14
42	focal palmoplantar keratoderma	13.8	GJB2, KRT16, KRT1
43	steatocystoma multiplex	13.8	KRT16, KRT17, KRT10
44	epidermolysis bullosa	13.8	IVL, FLG, LOR, KRT5, KRT17, KRT1
45	pachyonychia congenita	13.8	KRT5, KRT16, KRT17
46	trichoepithelioma	13.8	IVL, KRT17, KRT10, KRT14
47	chondrodysplasia punctata 2 x-linked dominant	13.7	GNPAT, STS, EBP
48	epidermolysis bullosa simplex	13.7	IVL, FLG, LOR, KRT5, KRT16, KRT86
49	monilethrix	13.7	IVL, KRT16, KRT86, KRT17, KRT9, KRT2
50	palmoplantar keratosis	13.7	LOR, GJB2, GJB6, NIPAL4, KRT1, KRT9

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ichthyosis:

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MGI Mouse Phenotypes related to ichthyosis:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	9.3	RARG, MAP2K1, MAP2K2, ARSB, FLG, ST14
2	pigmentation phenotype	MP:0001186	9.0	BRAF, KRT2, KRT17, KRT4, ERCC2, KRT14
3	hearing/vestibular/ear phenotype	MP:0005377	8.6	GJB2, MAP2K1, RARG, GJB6, CRABP2, KRT10
4	hematopoietic system phenotype	MP:0005397	7.7	FLG, BRAF, ITGB7, ARSA, SUMF1, ARSB
5	digestive/alimentary phenotype	MP:0005381	7.2	KRT17, KRAS, KRT14, TGFA, ST14, SLC27A4
6	vision/eye phenotype	MP:0005391	6.6	TGFA, ELOVL4, KRT14, KRAS, KRT4, ERCC2
7	integument phenotype	MP:0010771	6.5	GBA, ABHD5, ABCA12, KRT14, KRAS, KRT10
8	immune system phenotype	MP:0005387	6.4	PLCB3, CAPN1, ALOX12, LOR, ARSA, FLG
9	mortality/aging	MP:0010768	5.9	ERCC3, SUMF1, SPINK5, PPHLN1, PNPLA2, CRABP2
10	growth/size phenotype	MP:0005378	5.5	ERCC2, ERCC3, SUMF1, PNPLA2, NOD2, PHYH
11	homeostasis/metabolism phenotype	MP:0005376	4.5	PLCB3, NOD2, PHYH, KRT16, KRT1, KRAS

Articles related to ichthyosis:

(show top 50)    (show all 256)

id	Title	Authors	Year	Affiliating Genes
1	Harlequin ichthyosis in two siblings. (21798141)	Habib A.... Hameed A.	2011	ABCA12
2	NIPAL4/ichthyin is expressed in the granular layer of human epidermis and mutated in two Pakistani families with autosomal recessive ichthyosis. (20016120)	Wajid M.... Christiano A.M.	2010	NIPAL4
3	Genotype-phenotype correlations with TGM1: clustering of mutations in the bathing suit ichthyosis and self-healing collodion baby va riants of lamellar ichthyosis. (19863506)	Hackett B.C.... Irvine A.D.	2010	TGM1
4	Genotypic and clinical spectrum of self-improving col lodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients . (19890349)	Vahlquist A.... Fischer J.	2010	ALOX12B, TGM1, ALOXE3
5	A novel mutation in the L12 domain of keratin 1 is as sociated with mild epidermolytic ichthyosis. (20500210)	Bolling M.C.... van Geel M.	2010	KRT1
6	Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1. (19241467)	Herman M.L.... Toro J.R.	2009	TGM1
7	Atypical X-linked ichthyosis in a patient with a large deletion involving the steroid sulfatase (STS) gene. (19200188)	Gonzalez-Huerta L.... Cuevas-Covarrubias S.	2009	STS
8	Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup. (19183181)	Oji V.... McLean W.H.	2009	FLG
9	Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan. (18200065)	Nomura T.... McLean W.H.	2008	FLG
10	X-linked ichthyosis (steroid sulfatase deficiency) is associated with increased risk of attention deficit hyperactivity disorder, autism and social communication deficits. (18413370)	Kent L.... Yates J.R.	2008	STS, NLGN4X
11	Deletion of distal promoter of VCXA in a patient with X-linked ichthyosis associated with borderline mental retardation. (17113756)	Hosomi N.... Ishii M.	2007	STS
12	Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. (17139268)	Lesueur F.... Fischer J.	2007	ALOX12B, ALOX15B, ALOXE3
13	Recessive autosomal ichthyosis with hypotrichosis with mutation in the ST14 gene (17978729)	Dereure O.	2007	ST14
14	Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. (17273967)	Basel-Vanagaite L.... Shohat M.	2007	ST14
15	The South African 'bathing suit ichthyosis' is a form of lamellar ichthyosis caused by a homozygous missense mutation, p.R315L, in transglutaminase 1. (16977323)	Arita K.... McGrath J.A.	2007	TGM1
16	On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis. (17573887)	Hoffjan S.... Stemmler S.	2007	FLG
17	Perinatal lethal phenotype with generalized ichthyosis in a type 2 Gaucher disease patient with the [L444P;E326K]/P182L genotype: effect of the E326K change in neonatal and classic forms of the disease. (15967693)	Chabas A.... Vilageliu L.	2005	GBA
18	STS gene in a pedigree with X-linked ichthyosis. (16196306)	Liu A.... Liu Y.	2005	STS, KRT86
19	Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing. (15949009)	Akiyama M.... Shimizu H.	2005	KRT2
20	Detection of gene deletions in children with chondrodysplasia punctata, ichthyosis, Kallmann syndrome, and ocular albinism by FISH studies. (16323556)	Hou J.W.	2005	GPR143
21	A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. (15968592)	Sprecher E.... Mandel H.	2005	SNAP29
22	A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene. (16120162)	Mizuno Y.... Ogawa H.	2005	SPINK5
23	A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad. (15337980)	Montgomery J.R.... Holland S.M.	2004	GJB2
24	The clinical spectrum of congenital ichthyosis in Sweden: a review of 127 cases. (12822194)	Vahlquist A.... Westermark P.	2003	TGM1
25	Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome. (12752120)	Yotsumoto S.... Kanzaki T.	2003	GJB2
26	The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation. (12823437)	Dunnwald M.... Dale B.A.	2003	RELA, CAPN1, PLCB3
27	An Xp; Yq translocation causing a novel contiguous gene syndrome in brothers with generalized epilepsy, ichthyosis, and attention deficits. (14636323)	Doherty M.J.... Farrell D.F.	2003	ARSE
28	The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis. (12839564)	Zeeuwen P.L.... Schalkwijk J.	2003	CST6
29	New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens. (11531804)	Whittock N.V.... McGrath J.A.	2001	KRT1, KRT2
30	Diagnosis of autosomal recessive lamellar ichthyosis with mutations in the TGM1 gene. (11298529)	Cserhalmi-Friedman P.B.... Christiano A.M.	2001	TGM1
31	Carrier identification by FISH analysis in isolated cases of X-linked ichthyosis. (11477606)	Valdes-Flores M.... Cuevas-Covarrubias S.A.	2001	STS
32	Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population. (11844872)	Jimenez Vaca A.L.... Cuevas-Covarrubias S.A.	2001	STS
33	Two new loci for autosomal recessive ichthyosis on chromosomes 3p21 and 19p12-q12 and evidence for further genetic heterogeneity. (10712205)	Fischer J.... Prud'homme J.F.	2000	CYP4F22
34	Mutation report: a novel partial deletion of exons 2-10 of the STS gene in recessive X-linked ichthyosis. (10692123)	Valdes-Flores M.... Cuevas-Covarrubias S.A.	2000	STS
35	Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. (10844566)	Oyama N.... Kaneko F.	2000	STS
36	Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. (11121144)	Presland R.B.... Sundberg J.P.	2000	FLG
37	Lamellar ichthyosis: further narrowing, physical and expression mapping of the chromosome 2 candidate locus. (10094194)	Parmentier L.... Weissenbach J.	1999	ABCA12
38	Clinical and morphological correlations for transglutaminase 1 gene mutations in autosomal recessive congenital ichthyosis. (10482949)	Laiho E.... Saarialho-Kere U.	1999	TGM1
39	A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma. (9856845)	Suga Y.... Roop D.R.	1998	KRT10
40	Deletion pattern of the steroid sulphatase gene in Japanese patients with X-linked ichthyosis. (9764155)	Saeki H.... Ishibashi Y.	1998	STS
41	Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis. (9545389)	Hennies H.C.... Reis A.	1998	TGM1
42	Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity. (9359043)	Petit E.... Hovnanian A.	1997	TGM1
43	Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population. (9326318)	Laiho E.... Palotie A.	1997	TGM1
44	Genetic linkage of the keratin type II gene cluster with ichthyosis bullosa of Siemens and with autosomal dominant ichthyosis exfoliativa. (7521372)	Steijlen P.M.... Mariman E.C.	1994	KRT1
45	Linkage of autosomal recessive lamellar ichthyosis to chromosome 14q. (7977373)	Russell L.J.... Bale S.J.	1994	TGM1
46	X-linked dominant ichthyosis with peroxisomal deficiency. An ultrastructural and ultracytochemical study of the Conradi-Hunermann syndrome and its murine homologue, the bare patches mouse. (8129411)	Emami S.... Williams M.L.	1994	GNPAT
47	Harlequin ichthyosis. Variability in expression and hypothesis for disease mechanism. (7694551)	Dale B.A.... Kam E.	1993	DUSP19
48	Keratohyalin granules are heterogeneous in ridged and non-ridged human skin: evidence from anti-filaggrin immunogold labelling of normal skin and skin of autosomal dominant ichthyosis vulgaris patients. (1724895)	GA1nzel S.... Anton-Lamprecht I.	1991	FLG
49	Deletion of the distal short arm of the X chromosome (Xp) in a patient with short stature, chondrodysplasia punctata, and X-linked ichthyosis due to steroid sulfatase deficiency. (1785631)	Ballabio A.... Strisciuglio P.	1991	STS
50	Ichthyosis and steroid sulfatase: study of enzymatic activity in leukocytes and fibroblasts according to the sex and type of ichthyosis (2158060)	Piraud M.... Barrut D.	1990	STS

Genes related to ichthyosis according to GeneCards:

(show top 50)    (show all 117)

id	Symbol	Description	Score	GeneCards Section Context
1	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.1	Publications, Summaries
2	FLG	filaggrin	11.1	Publications, Summaries
3	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12	11.1	Aliases & Descriptions, Publications
4	STS	steroid sulfatase (microsomal), isozyme S	11.1	Publications, Summaries
5	SPINK5	serine peptidase inhibitor, Kazal type 5	11.1	Summaries, Publications
6	NIPAL4	NIPA-like domain containing 4	11.1	Orthologs, Summaries, Publications
7	ALOXE3	arachidonate lipoxygenase 3	11.1	Summaries, Publications
8	CYP4F22	cytochrome P450, family 4, subfamily F, polypeptide 22	11.1	Publications, Summaries
9	INLNE	Ichthyosis, nonlamellar and nonerythrodermic, congenital, autosomal recessive	11.1	Aliases & Descriptions, Publications
10	LI5	Lamellar ichthyosis 5	11.1	Aliases & Descriptions, Publications
11	KRT2	keratin 2	11.1	Aliases & Descriptions, Publications
12	ICR1	ichthyosis congenita I, erythromatous lamellar ichthyosis, ichthyosiform erythroderma	11.1	Aliases & Descriptions
13	ICR4	ichthyosis congenita IV, ichthyosis-prematurity syndrome	11.1	Aliases & Descriptions
14	LIPN	lipase, family member N	11.1	Publications, Summaries
15	MBTPS2	membrane-bound transcription factor peptidase, site 2	11.1	Publications, Summaries
16	CLDN1	claudin 1	11.1	Summaries, Publications
17	SLC27A4	solute carrier family 27 (fatty acid transporter), member 4	11.0	Publications, Summaries
18	ICR3	ichthyosis congenita III, vulgaris-like recessive ichthyosis	11.0	Aliases & Descriptions
19	ICR5	ichthyosis congenita V, Sjogren-Larsson-like	11.0	Aliases & Descriptions
20	KRT1	keratin 1	11.0	Publications
21	KRT10	keratin 10	11.0	Publications
22	LOR	loricrin	11.0	Publications
23	ALOX12B	arachidonate 12-lipoxygenase, 12R type	11.0	Publications
24	IVL	involucrin	11.0	Publications
25	ALDH3A2	aldehyde dehydrogenase 3 family, member A2	11.0	Publications
26	ST14	suppression of tumorigenicity 14 (colon carcinoma)	11.0	Publications
27	ARSH	arylsulfatase family, member H	11.0	Publications
28	KRT5	keratin 5	11.0	Publications
29	VCX3A	variable charge, X-linked 3A	11.0	Publications
30	ABHD5	abhydrolase domain containing 5	11.0	Publications
31	CSTA	cystatin A (stefin A)	11.0	Publications
32	SNAP29	synaptosomal-associated protein, 29kDa	11.0	Publications
33	PRSS8	protease, serine, 8	11.0	Publications
34	NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	11.0	Orthologs, Publications
35	ALOX15B	arachidonate 15-lipoxygenase, type B	11.0	Publications
36	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1	11.0	Publications
37	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
38	TMPRSS11A	transmembrane protease, serine 11A	11.0	Publications
39	NIPAL2	NIPA-like domain containing 2	11.0	Publications
40	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
41	GBA	glucosidase, beta, acid	11.0	Publications
42	KRT14	keratin 14	11.0
43	PNPLA1	patatin-like phospholipase domain containing 1	11.0	Summaries
44	XGPY2	Xg pseudogene, Y-linked 2	11.0
45	VCY	variable charge, Y-linked	11.0
46	VCY1B	variable charge, Y-linked 1B	11.0
47	VCX3B	variable charge, X-linked 3B	11.0	Publications
48	VCX	variable charge, X-linked	11.0	Publications
49	VCX2	variable charge, X-linked 2	11.0	Publications
50	CST6	cystatin E/M	11.0	Publications

Pathways related to ichthyosis according to GeneDecks:

(show all 25)

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Keratin filaments10	10.6	KRT5, KRT1, KRT2, KRT16, KRT14, KRT4
2	Cytoskeleton remodeling_Keratin filaments41	10.6	KRT2, KRT17, KRT16, KRT4, KRT5, KRT14
3	HETE and HPETE biosynthesis and metabolism41	10.2	EPHX2, ALOX12, ALOX15B, ALOX12B, CYP4F2
4	HETE and HPETE biosynthesis and metabolism10	10.2	EPHX2, CYP4F2, ALOX15B, ALOX12B, ALOX12
5	Arachidonic acid metabolism20	10.1	ALOX12B, ALOX15B, CYP4F2, EPHX2, ALOX12
6	Metabolism of lipids and lipoproteins38	9.9	LBR, GBA, EBP, SLC27A1, STS, ABHD5
7	Sorafenib Pharmacodynamics34	9.5	KRAS, MAP2K1, BRAF
8	Pathway_PA16595942534	9.3	KRAS, MAP2K2, MAP2K1, BRAF
9	Signaling in Gap Junctions36	9.3	BRAF, GJB2, GJB3, PLCB3, MAP2K1, MAP2K2
10	Pathway_PA16598005034	9.3	MAP2K1, BRAF, MAP2K2, KRAS
11	Acute myeloid leukemia20	9.3	MAP2K2, MAP2K1, BRAF, KRAS
12	Thyroid cancer20	9.2	KRAS, BRAF, MAP2K2, MAP2K1
13	Development A2B receptor- action via G-protein alpha s10	9.2	MAP2K1, BRAF, MAP2K2, PLCB3, RELA
14	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways37	9.2	BRAF, MAP2K2, MAP2K1, KRAS
15	Development_A2B receptor- action via G-protein alpha s41	9.2	BRAF, MAP2K2, MAP2K1, PLCB3, RELA
16	IL-2 Signaling Pathways37	9.2	MAP2K2, BRAF, KRAS, MAP2K1
17	G-protein signaling Ras family GTPases in kinase cascades (scheme)10	9.1	MAP2K2, BRAF, MAP2K1, KRAS
18	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	9.1	BRAF, KRAS, MAP2K1, MAP2K2
19	Long-term potentiation20	8.8	BRAF, MAP2K2, MAP2K1, PLCB3, KRAS
20	Long-term depression20	8.7	PLCB3, KRAS, BRAF, MAP2K2, MAP2K1
21	Non-small cell lung cancer20	8.7	MAP2K2, BRAF, TGFA, MAP2K1, KRAS
22	Glioma20	8.4	KRAS, MAP2K1, MAP2K2, BRAF, TGFA
23	Prostate cancer20	8.3	RELA, BRAF, MAP2K1, KRAS, TGFA, MAP2K2
24	Renal cell carcinoma20	8.3	MAP2K1, MAP2K2, BRAF, KRAS, TGFA
25	Pancreatic cancer20	8.0	KRAS, MAP2K1, RELA, BRAF, TGFA

Compounds related to ichthyosis according to GeneDecks:

(show top 50)    (show all 53)

id	Compound	Score	Top Affiliating Genes
1	collodion32	10.9	LOR, IVL, TGM1, GBA
2	calcipotriol32 42 9 9	13.8	FLG, KRT14, TGM1, KRT16, IVL, KRT5
3	cholesterol-sulfate32 9 9	12.8	TGM1, SULT2A1, IVL, STS
4	tazarotene32 9 9	12.8	KRT1, RARG, KRT2, KRT10
5	hematoxylin32	10.8	KRT1, KRT10, LOR, KRT14, FLG, IVL
6	pregnenolone sulfate32	10.7	SULT2A1, ARSH, STS
7	epsilon-(gamma-glutamyl)lysine32	10.5	IVL, LOR, TGM1
8	acitretin32 9 9	12.5	IVL, RARG, KRT5, KRT17
9	histidine32	10.5	KRT10, STS, KRT14, KRT5, ARSH, FLG
10	ceramides32	10.4	KRT1, DUSP19, IVL, PPP2R4, GBA
11	asparagine32	10.4	GJB2, KRT17, KRT5, GBA, KRT1, SERPINA7
12	retinoid32	10.4	IGFBP6, RARG, IVL, FLG, GJB2, CRABP2
13	dydrogesterone32 9 9	12.4	STS, ARSH, CGA
14	sodium dodecylsulfate32	10.4	SERPINA7, KRT1, TGM1, CRABP2, KRT16, KRT17
15	mucopolysaccharide32	10.3	ARSH, ARSA, ARSB, STS
16	cerebroside32	10.3	STS, ARSH, ARSB, ARSA
17	formylglycine32	10.3	ARSB, ARSA, ARSH, SUMF1
18	dithranol32	10.2	KRT10, KRT16, FLG, IVL, TGFA
19	lysine32	10.0	KRT5, KRT86, IVL, SERPINB2, RELA, LELP1
20	tcdd32	10.0	KRT10, IVL, SERPINB2, TGFA, ARSH
21	estrone32 9 18 9	12.9	STS, ARSH, ARSE, ARSA, ARSB, SULT2A1
22	bromodeoxyuridine32	9.9	TGFA, KRT14, KRT10, FLG, IVL, LBR
23	gf 109203x32 42	10.8	TGM1, FLG, TGFA, IVL, DUSP19, MAP2K1
24	vitamin a32 9 18 9	12.8	KRT14, TGM1, SOD1, LOR, KRT16, KRT5
25	ceramide32	9.7	IVL, FLG, ARSA, MAP2K1, DUSP19, PPP2R4
26	cholesterol32 9 18 9	12.7	IVL, MBTPS2, MAP2K1, LOR, ERCC2, SULT2A1
27	arachidonic acid32 9 18 9	12.4	ALOXE3, ALOX15B, EPHX2, SLC27A1, ALOX12B, PNPLA2
28	phorbol32	9.3	MAP2K1, ALOX12, ALOX15B, DUSP19, PPP2R4, TGFA
29	tamoxifen32 34 9 9	12.1	EPHX2, IGFBP6, EBP, STS, TGFA, KRT14
30	vitamin d32	9.0	SULT2A1, IVL, CGA, LBR, CRABP2, TGM1
31	12-o-tetradecanoylphorbol 13-acetate32	8.9	BRAF, CSTA, MAP2K1, TGFA, KRT5, PPP2R4
32	forskolin32 42 9 9	11.8	GJB2, BRAF, DUSP19, LBR, CGA, IVL
33	ascorbic acid32 18	9.8	PPP2R4, SERPINB2, CGA, EPHX2, FLG, DUSP19
34	matrigel32	8.5	SERPINB2, TIAM1, GJB2, ALOX12, MAP2K1, BRAF
35	fatty acid32	8.5	BRAF, IVL, ALDH3A2, ALOX12, GNPAT, HLCS
36	cysteine32	8.4	ARSA, EPHX2, STS, TGFA, FLG, KRT14
37	steroid32	8.3	FLG, ARSH, TGFA, ALOX15B, SULT2A1, CRABP2
38	progesterone32 42 9 18 9	12.3	IGFBP6, KRT5, KRT1, KRT10, KRT14, TGFA
39	paraffin32	8.2	KRT17, KRT1, BRAF, KRT10, KRAS, KRT14
40	proline32	8.2	GJB3, GJB2, CAPN1, LOR, MAP2K1, ARSA
41	cisplatin32 34 9 9	11.1	BRAF, LBR, PPP2R4, KRT14, KRAS, DUSP19
42	testosterone32 9 18 9	10.9	PPP2R4, SULT2A1, LBR, CGA, MAP2K1, ARSH
43	arginine32	7.7	TGFA, TGM1, SOD1, KRT14, EPHX2, KRT9
44	cycloheximide32	7.6	ALOX12, MAP2K1, MAP2K2, CGA, LBR, SERPINB2
45	retinoic acid32 42 18	9.5	IVL, KRAS, MAP2K1, IGFBP6, LOR, ALOX12
46	estrogen32	7.2	KRT4, KRT5, KRT1, KRAS, KRT14, KRT10
47	calcium32 9 18 9	10.1	LELP1, TGM3, ST14, EBP, STS, ITGB7
48	lipid32	6.9	SERPINA7, SULT2A1, PPP2R4, PNPLA2, CRABP2, NISCH
49	serine32	6.6	ALDH3A2, RELA, SERPINA7, SERPINB2, BRAF, CDSN
50	tyrosine32	6.4	MAP2K1, KRT1, MAP2K2, ARSH, FLG, ITGB7

Cellular components related to ichthyosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	keratin filament	GO:045095	10.1	KRT2, KRT9, KRT10, KRT1, KRT86, KRT5
2	cornified envelope	GO:001533	10.1	CDSN, CSTA, CST6, TGM1, RPTN, SPRR1B
3	intermediate filament	GO:005882	9.9	KRT14, KRT2, KRT10, KRT1, KRT17, KRT86

Biological processes related to ichthyosis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	magnesium ion transport	GO:015693	10.5	NIPAL4, NIPA1, NIPA2, NIPAL1
2	peptide cross-linking	GO:018149	10.3	IVL, CSTA, LOR, SPRR1B, SPRR3, TGM1
3	leukotriene biosynthetic process	GO:019370	10.3	ALOX12B, ALOX15B, ALOXE3, ALOX12
4	keratinization	GO:031424	10.2	TGM3, TGM1, KRT2, PPHLN1, SPRR3, LOR
5	hair cell differentiation	GO:035315	10.2	SPINK5, ERCC3, ERCC2
6	skin development	GO:043588	10.1	GJB3, ERCC2, KRT9, STS, SLC27A4
7	keratinocyte differentiation	GO:030216	9.9	IVL, TGM1, MAP2K1, CDSN, FLG, SPRR3
8	glycosphingolipid metabolic process	GO:006687	9.9	GBA, SUMF1, ARSA, ARSE, ARSH, ARSB
9	epidermis development	GO:008544	9.9	ALDH3A2, KRT17, SPRR1B, SPRR3, CRABP2, KRT5
10	sphingolipid metabolic process	GO:006665	9.9	ARSB, SUMF1, ARSH, ARSE, ARSA, STS
11	phospholipid metabolic process	GO:006644	9.6	ARSH, SUMF1, PNPLA2, STS, GBA, ARSE
12	small molecule metabolic process	GO:044281	8.1	SULT2A1, SUMF1, CYP4F2, PNPLA2, PHYH, ABHD5

Molecular functions related to ichthyosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:005200	10.2	KRT2, KRT14, LOR, KRT5, KRT16, KRT17
2	lipoxygenase activity	GO:016165	10.0	ALOX12, ALOX12B, ALOX15B, ALOXE3
3	structural molecule activity	GO:005198	9.9	CSTA, KRT86, KRT4, SPRR3, CLDN1, IVL
4	arylsulfatase activity	GO:004065	9.8	ARSB, ARSA, ARSE, ARSH