MCID: ICH018
MIFTS: 16

Ichthyosis Linearis Circumflexa

Categories: Rare diseases

Aliases & Classifications for Ichthyosis Linearis Circumflexa

MalaCards integrated aliases for Ichthyosis Linearis Circumflexa:

Name: Ichthyosis Linearis Circumflexa 49 69

Classifications:



Summaries for Ichthyosis Linearis Circumflexa

MalaCards based summary : Ichthyosis Linearis Circumflexa is related to netherton syndrome and ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Ichthyosis Linearis Circumflexa is SPINK5 (Serine Peptidase Inhibitor, Kazal Type 5). The drugs Tacrolimus and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Ichthyosis Linearis Circumflexa

Diseases related to Ichthyosis Linearis Circumflexa via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 netherton syndrome 12.2
2 ichthyosis 11.0
3 dwarfism 10.3

Symptoms & Phenotypes for Ichthyosis Linearis Circumflexa

UMLS symptoms related to Ichthyosis Linearis Circumflexa:


trichorrhexis invaginata

Drugs & Therapeutics for Ichthyosis Linearis Circumflexa

Drugs for Ichthyosis Linearis Circumflexa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
2
Adalimumab Approved Phase 2 331731-18-1 16219006
3
Pimecrolimus Approved, Investigational Phase 1, Phase 2 137071-32-0 17753757 6447131
4 Analgesics Phase 1, Phase 2
5 Analgesics, Non-Narcotic Phase 1, Phase 2
6 Dermatologic Agents Phase 1, Phase 2
7 Peripheral Nervous System Agents Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Anti-Inflammatory Agents Phase 2,Phase 1
10 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
11 Antirheumatic Agents Phase 2,Phase 1
12 Calcineurin Inhibitors Phase 1, Phase 2
13 Antibodies, Monoclonal Phase 2
14 Immunoglobulins Phase 2
15 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Using Humira in Netherton Syndrome Completed NCT02113904 Phase 2 Adalimumab
2 Safety Study of Elidel (Pimecrolimus) 1% Cream to Treat Netherton Syndrome Completed NCT00208026 Phase 1, Phase 2 Pimecrolimus 1% Cream
3 The Efficacy and Safety of Secukinumab in Patients With Ichthyoses Recruiting NCT03041038 Phase 2 Secukinumab;Placebo
4 A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome Completed NCT01428297 Phase 1 BPR277 ointment (controlled application);Placebo (Vehicle);BPR277 ointment;Placebo (Vehicle);BPR277;Placebo (Vehicle)
5 Gene Therapy for Netherton Syndrome Recruiting NCT01545323 Phase 1
6 Natural History and Biological Study of Netherton Syndrome Unknown status NCT02081313
7 Defining the Skin and Blood Biomarkers of Ichthyosis Recruiting NCT03417856
8 Natural History of Diseases Associated With Allergic Inflammation: Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways Recruiting NCT01164241

Search NIH Clinical Center for Ichthyosis Linearis Circumflexa

Genetic Tests for Ichthyosis Linearis Circumflexa

Anatomical Context for Ichthyosis Linearis Circumflexa

MalaCards organs/tissues related to Ichthyosis Linearis Circumflexa:

38
Skin

Publications for Ichthyosis Linearis Circumflexa

Articles related to Ichthyosis Linearis Circumflexa:

(show all 24)
# Title Authors Year
1
Ichthyosis linearis circumflexa with bamboo hair: challenges in the diagnosis and management. ( 28554884 )
2017
2
Ichthyosis linearis circumflexa in a child. Response to narrowband UVB therapy. ( 26848320 )
2015
3
Ichthyosis Linearis Circumflexa as the Only Clinical Manifestation of Netherton Syndrome. ( 25710899 )
2015
4
Netherton syndrome with ichthyosis linearis circumflexa and trichorrhexis invaginatum. ( 25526335 )
2014
5
Ichthyosis linearis circumflexa. ( 21220804 )
2010
6
A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene. ( 16120162 )
2005
7
Clearance of ichthyosis linearis circumflexa with balneophototherapy. ( 11305383 )
2000
8
A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus. ( 10688732 )
2000
9
Ichthyosis linearis circumflexa. ( 20948134 )
1996
10
Ichthyosis linearis circumflexa: morphological and biochemical studies. ( 2579669 )
1985
11
Successful therapy of ichthyosis linearis circumflexa with PUVA. ( 6863655 )
1983
12
Ichthyosis linearis circumflexa [proceedings]. ( 7387896 )
1980
13
Ichthyosis linearis circumflexa. ( 479434 )
1979
14
Explorations of antimitotic agents in the treatment of a congenital disease, ichthyosis linearis circumflexa. ( 439902 )
1979
15
Ichthyosis linearis circumflexa ComA"l and Netherton's syndrome; an ultrastructural study. ( 467759 )
1979
16
Ichthyosis linearis circumflexa comA"l with trichorrhexis invaginata (Netherton's syndrome). A light microscopical study of the skin changes. ( 4480415 )
1974
17
Ichthyosis linearis circumflexa comA"l. A clinico-statistical approach to its relationship with Netherton's syndrome. ( 4480416 )
1974
18
Ichthyosis linearis circumflexa and Netherton's syndrome with idiopathic dwarfism. ( 4800202 )
1973
19
Ichthyosis linearis circumflexa ComA"l with Trichorrhexis invaginata (Netherton's Syndrom): an ultrastructural study of the skin changes. ( 4678924 )
1972
20
Netherton's disease and ichthyosis linearis circumflexa. Report of a case and review of the literature. ( 4115884 )
1972
21
Netherton's syndrome and ichthyosis linearis circumflexa. ( 5467454 )
1970
22
Netherton's disease and ichthyosis linearis circumflexa. ( 5797972 )
1969
23
Neterton's syndrome and ichthyosis linearis circumflexa. ( 4242601 )
1969
24
Multiple defects of the hair shaft in Netherton's disease. Association with ichthyosis linearis circumflexa. ( 5359904 )
1969

Variations for Ichthyosis Linearis Circumflexa

Expression for Ichthyosis Linearis Circumflexa

Search GEO for disease gene expression data for Ichthyosis Linearis Circumflexa.

Pathways for Ichthyosis Linearis Circumflexa

GO Terms for Ichthyosis Linearis Circumflexa

Sources for Ichthyosis Linearis Circumflexa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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