IXL
MCID: ICH054
MIFTS: 46

Ichthyosis, X-Linked (IXL) malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Skin diseases

Aliases & Classifications for Ichthyosis, X-Linked

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 30ICD10, 31ICD10 via Orphanet, 35LifeMap Discovery®, 37MedGen, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Ichthyosis, X-Linked:

Name: Ichthyosis, X-Linked 52 24 70 12 39 68
X-Linked Ichthyosis 35 11 48 54 13
Placental Steroid Sulfatase Deficiency 48 24 70 68
Steroid Sulfatase Deficiency 48 24 54 70
Steroid Sulfatase Deficiency Disease 48 68
X-Linked Ichthyosis with Steryl-Sulphatase Deficiency 11
X-Linked Placental Steryl-Sulphatase Deficiency 11
Syndromic Recessive X-Linked Ichthyosis 54
Recessive X-Linked Ichthyosis 54
X-Linked Recessive Ichthyosis 11
 
Syndromic X-Linked Ichthyosis 54
Ichthyosis X-Linked 50
X Linked Ichthyosis 48
Syndromic Rxli 54
Rxli 54
Ssdd 48
Ssd 48
Ixl 70
Xli 54

Characteristics:

Orphanet epidemiological data:

54
x-linked ichthyosis:
Inheritance: X-linked recessive; Prevalence: 1-5/10000 (Europe); Age of onset: Neonatal; Age of death: normal life expectancy
syndromic recessive x-linked ichthyosis:
Inheritance: X-linked recessive; Prevalence: 1-9/100000 (Europe); Age of onset: Childhood

HPO:

64
ichthyosis, x-linked:
Inheritance: x-linked recessive inheritance

Classifications:



External Ids:

OMIM52 308100
Disease Ontology11 DOID:1700
ICD1030 Q80.1
MeSH39 D016114
NCIt45 C84779
MESH via Orphanet40 D016114
UMLS via Orphanet69 C0079588, C2717836
ICD10 via Orphanet31 Q80.1

Summaries for Ichthyosis, X-Linked

About this section
NIH Rare Diseases:48 X-linked ichthyosis is a disorder in which the skin cells are produced at a normal rate but they do not separate properly at the surface of the stratum corneum (the outermost layer of the skin). this slows the rate of shedding of the skin cells, resulting in a build-up of scales. the scales of x-linked ichthyosis are often dark and usually cover only a portion of the body. typically, the trunk and back of the neck are more likely to be affected. scales are usually not found on the face, scalp, palms of the hands, and soles of the feet. x-linked ichthyosis mostly affects males. it is usually caused by a mutation or deletion in the sts gene and is inherited in an x-linked recessive manner. in rare cases, the ichthyosis can be part of a genetic syndrome in which other parts of the body are affected. topical treatment may consist of alpha-hydroxy acids, lubricating bath oils, and emollients. for adult patients, systemic retinoids may be an option, especially during winter when the ichthyosis is often more severe. the ichthyosis is life-long, but the scaling may improve with age. last updated: 3/15/2016

MalaCards based summary: Ichthyosis, X-Linked, also known as x-linked ichthyosis, is related to chondrodysplasia punctata with steroid sulfatase deficiency and doughnut lesions of skull, familial, and has symptoms including Array, Array and Array. An important gene associated with Ichthyosis, X-Linked is STS (Steroid Sulfatase), and among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Sphingolipid metabolism. Affiliated tissues include skin and eye, and related mouse phenotype Increased viability.

OMIM:52 Ichthyosis is a genetically heterogeneous disorder of the skin. See, e.g., autosomal dominant ichthyosis vulgaris... (308100) more...

UniProtKB/Swiss-Prot:70 Ichthyosis, X-linked: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.

Wikipedia:71 X-linked ichthyosis (XLI) (also known as \"Steroid sulfatase deficiency,\" and \"X-linked recessive... more...

Related Diseases for Ichthyosis, X-Linked

About this section

Diseases related to Ichthyosis, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1chondrodysplasia punctata with steroid sulfatase deficiency12.1
2doughnut lesions of skull, familial10.2ARSH, STS
3ichthyosis10.2
4dyschromatosis universalis hereditaria10.2ARSH, STS
5amyotrophic lateral sclerosis 1910.1FLG, TGM1
6episodic angioedema with eosinophilia10.1FLG, KRT10
7brachydactyly small stature face anomalies10.1FLG, KRT10
8atelosteogenesis ii10.1FLG, TGM1
9thymus mucoepidermoid carcinoma10.1FLG, KRT10
10familial acute necrotizing encephalopathy10.1FLG, KRT10
11muscle disorders10.1ARSH, SUMF1
12neuronopathy, distal hereditary motor, type iic10.1ARSH, SUMF1
13ectodermal dysplasia, hypohidrotic, with immune deficiency10.1ARSH, SUMF1
14pachyonychia congenita 210.1FLG, KRT10
15malignant spindle cell melanoma10.1FLG, KRT10
16ichthyosis histrix, curth-macklin type10.1FLG, KRT10
17dermatitis, atopic 210.0FLG, STS, TGM1
18cole-carpenter syndrome 110.0FLG, KRT10
19mitochondrial dna depletion syndrome 110.0ARSH, SUMF1
20intraocular retinoblastoma10.0FLG, KRT10
21mast-cell leukemia10.0FLG, KRT10
22obesity10.0ARSH, STS, SUMF1
23vascular dementia10.0FLG, KRT10
24solitary bone cyst10.0FLG, KRT10, TGM1
25breast leiomyoma9.9FLG, KRT10
26insulinoma9.8FLG, KRT10, STS, TGM1
27preauricular tag, isolated, autosomal dominant, 19.8FLG, KRT10, STS, TGM1
28autosomal dominant nocturnal frontal lobe epilepsy9.8FLG, KRT10, STS, TGM1
29richter's syndrome9.8FLG, KRT10, STS, TGM1
30steroid inherited metabolic disorder9.8FLG, KRT10, STS, TGM1
31secondary progressive multiple sclerosis9.8NLGN4X, VCX2, VCX3A
32pancreatic cancer9.8
33pancreatitis9.8
34ichthyosis vulgaris9.8
35chondrodysplasia punctata, x-linked recessive8.8ARSH, FLG, KRT10, NLGN4X, STS, SUMF1

Graphical network of the top 20 diseases related to Ichthyosis, X-Linked:



Diseases related to ichthyosis, x-linked

Symptoms & Phenotypes for Ichthyosis, X-Linked

About this section

Symptoms by clinical synopsis from OMIM:

308100

Clinical features from OMIM:

308100

Human phenotypes related to Ichthyosis, X-Linked:

 54 64 (show all 27)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cryptorchidism64 54 Occasional (29-5%) HP:0000028
2 autism64 54 Occasional (29-5%) HP:0000717
3 dry skin64 54 Very frequent (99-80%) HP:0000958
4 hyperkeratosis64 54 Very frequent (99-80%) HP:0000962
5 hypohidrosis64 54 Very frequent (99-80%) HP:0000966
6 neurological speech impairment64 54 Occasional (29-5%) HP:0002167
7 attention deficit hyperactivity disorder64 54 Frequent (79-30%) HP:0007018
8 opacification of the corneal stroma64 54 Frequent (79-30%) HP:0007759
9 ichthyosis64 54 Very frequent (99-80%) HP:0008064
10 renal insufficiency64 54 Occasional (29-5%) HP:0000083
11 unilateral renal agenesis64 54 Occasional (29-5%) HP:0000122
12 hypogonadism64 54 Occasional (29-5%) HP:0000135
13 intellectual disability64 54 Frequent (79-30%) HP:0001249
14 seizures64 54 Occasional (29-5%) HP:0001250
15 global developmental delay64 54 Frequent (79-30%) HP:0001263
16 lissencephaly64 54 Occasional (29-5%) HP:0001339
17 dysphasia64 54 Frequent (79-30%) HP:0002357
18 acute leukemia64 54 Occasional (29-5%) HP:0002488
19 abnormality of the stomach64 54 Occasional (29-5%) HP:0002577
20 abnormality of the abdominal wall54 Occasional (29-5%)
21 short stature64 54 Occasional (29-5%) HP:0004322
22 corneal opacity64 54 Frequent (79-30%) HP:0007957
23 abdominal wall defect64 54 Occasional (29-5%) HP:0010866
24 testicular seminoma64 54 Occasional (29-5%) HP:0100617
25 abnormality of metabolism/homeostasis64 HP:0001939
26 neoplasm64 HP:0002664
27 congenital ichthyosiform erythroderma64 HP:0007431

GenomeRNAi Phenotypes related to Ichthyosis, X-Linked according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00386-A-16.9FLG, KRT10, NLGN4X, STS, SUMF1, VCX2

Drugs & Therapeutics for Ichthyosis, X-Linked

About this section

Drugs for Ichthyosis, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 236)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LorazepamapprovedPhase 4124846-49-13958
Synonyms:
(+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
(+/-)-Lorazepam
(±)-Lorazepam
5-25-02-00248 (Beilstein Handbook Reference)
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
846-49-1
AC1L1H3H
AHP Brand of Lorazepam
Almazine
Alzapam
Anxiedin
Anxira
Anzepam
Aplacasse
Aplacassee
Apo Lorazepam
Apo-Lorazepam
ApoLorazepam
Apotex Brand of Lorazepam
Aripax
Ativan
Ativan (TN)
Azurogen
BRN 0759084
Baxter Brand of Lorazepam
Bonatranquan
Bonton
CHEBI:116959
CHEMBL580
CID3958
CPD000058410
D00365
D008140
DB00186
DEA No. 2885
Delormetazepam
Demethyllormetazepam
Desitin Brand of Lorazepam
DivK1c_000965
Dolorgiet Brand of Lorazepam
Donix
Duralozam
Durazolam
EINECS 212-687-6
Efasedan
Emotion
Emotival
Equitam
HMS2052H07
HMS503A11
IDI1_000965
Idalprem
KBio1_000965
Kalmalin
L-Lorazepam Acetate
L1764_SIGMA
LS-34141
Larpose
Laubeel
Llorens Brand of Lorazepam
Lomesta
Lopam
Lorabenz
Lorafen
Loram
Lorans
Lorapam
Lorat
Lorax
Loraz
Lorazene
Lorazep
Lorazepam (JP15/USP/INN)
Lorazepam AHP Brand
Lorazepam Apotex Brand
Lorazepam Baxter Brand
Lorazepam Desitin Brand
Lorazepam Dolorgiet Brand
Lorazepam Fabra
Lorazepam Genericon
Lorazepam Intensol
Lorazepam Lannacher
Lorazepam Llorens Brand
Lorazepam Medical
Lorazepam Medical Brand
Lorazepam Medix Brand
Lorazepam Novartis Brand
Lorazepam Novopharm Brand
Lorazepam Nu-Pharm Brand
Lorazepam Riemser Brand
Lorazepam Wyeth Brand
Lorazepam [USAN:INN:BAN:JAN]
Lorazepam ct-Arzneimittel Brand
 
Lorazepam neuraxpharm
Lorazepam neuraxpharm Brand
Lorazepam preservative free
Lorazepam ratiopharm
Lorazepam ratiopharm Brand
Lorazepam-Efeka
Lorazepam-neuraxpharm
Lorazepam-ratiopharm
Lorazepamum
Lorazepamum [INN-Latin]
Lorazepan Chobet
Lorazepan Richet
Lorazin
Lorazon
Lorenin
Loridem
Lorivan
Lormetazepam
Lorsedal
Lorsilan
Lorzem
Lozepam
Max Pax
Medical Brand of Lorazepam
Medical, Lorazepam
Medix Brand of Lorazepam
Merck dura Brand of Lorazepam
Merlit
Methyllorazepam
MolPort-002-051-769
N-Methyllorazepam
NCGC00159439-02
NINDS_000965
NSC 289758
NSC289758
Nervistop L
Nervistopl
Norlormetazepam
Novartis Brand of Lorazepam
Novhepar
Novo Lorazem
Novo-Lorazem
Novolorazem
Novopharm Brand of Lorazepam
Nu Loraz
Nu Pharm Brand of Lorazepam
Nu-Loraz
Nu-Pharm Brand of Lorazepam
NuLoraz
O-Chlorooxazepam
O-Chloroxazepam
Orfidal
Orfidal Wyeth
Pro Dorm
Pro dorm
Psicopax
Punktyl
Quait
Renaquil
Riemser Brand of Lorazepam
Rocosgen
SAM001246833
Securit
Sedatival
Sedazin
Sedicepan
Sedizepan
Serra Pamies Brand of Lorazepam
Sidenar
Silence
Sinestron
Somagerol
Stapam
Tavor
Temesta
Tolid
Tranqipam
Trapax
UNII-O26FZP769L
Upan
Vigiten
WLN: T67 GMV JN IHJ CG IQ KR BG
WY4036
Wy 4036
Wy-4036
Wyeth Brand of Lorazepam
Wyeth, Orfidal
Wypax
ct Arzneimittel Brand of Lorazepam
ct-Arzneimittel Brand of Lorazepam
lorazep von ct
lorazepam
lorazepam (Ativan)
nchembio747-comp26
neuraxpharm Brand of Lorazepam
o-Chlorooxazepam
o-Chloroxazepam
ratiopharm Brand of Lorazepam
2
Pregabalinapproved, illicit, investigationalPhase 4, Phase 3361148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
3
Miconazoleapproved, investigational, vet_approvedPhase 4, Phase 1, Phase 2370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
4
Selegilineapproved, investigational, vet_approvedPhase 4, Phase 3, Phase 22714611-51-926757, 5195
Synonyms:
(-)-(N)-Methyl-N-((1R)-1-methyl-2-phenylethyl)prop-2-yn-1-amine
(-)-Deprenil
(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
(R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine
(R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin
(−)-selegiline
14611-51-9
14611-52-0 (hydrochloride)
2079-54-1 (deprenyl.hydrochloride)
AC1L1BTZ
AC1Q2860
AKOS000281115
Anipryl
Apo-Selegiline
BPBio1_000687
BRD-K86434416-001-02-7
BRD-K86434416-003-03-1
BSPBio_000623
BSPBio_001589
C07245
C13H17N
CHEBI:9086
CHEMBL972
CID26757
Carbex
D03731
DB01037
Deprenyl
Eldepryl
Emsam
Emsam (TN)
Gen-Selegiline
HMS1791P11
HMS1989P11
HMS2089D09
Humex
 
Jumex
L-Deprenalin
L-Deprenyl
LS-30156
MolPort-000-883-771
N-methyl-N-[(1R)-1-methyl-2-phenylethyl]prop-2-yn-1-amine
N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine
NCGC00024994-01
NCGC00024994-02
NCGC00024994-03
NCGC00024994-04
Novo-Selegiline
Nu-Selegiline
Prestwick0_000552
Prestwick1_000552
Prestwick2_000552
Prestwick3_000552
SPBio_002544
STK640578
Sd Deprenyl
Selegeline Hcl
Selegilina
Selegilina [INN-Spanish]
Selegiline (USAN/INN)
Selegiline Transdermal System (STS) patch
Selegiline [INN:BAN]
Selegiline, (R)-Isomer
Selegilinum
Selegilinum [INN-Latin]
Selegyline
Tocris-1095
UNII-2K1V7GP655
Yumex
ZINC19632633
Zelapar
l-E 250
selegiline
5
Sodium Tetradecyl SulfateapprovedPhase 461191-50-0, 139-88-814492, 5248
Synonyms:
1-Tetradecanol, 1-(hydrogen sulfate), sodium salt (1:1)
1-Tetradecanol, hydrogen sulfate, sodium salt
1191-50-0
22088-37-5
7-Ethyl-2-methyl-4-undecanol sulfate sodium salt
7-ethyl-2-methyl-4-undecanolsulfate, sodium salt
C14H28O5S
CHEMBL541505
CID14492
EINECS 214-737-2
LS-148911
Monotetradecylsulfate sodium salt
Monotetradecylsulphate sodium salt
Myristyl sulfate, sodium salt
NSC 139032
Natri tetradecylsulfas
Natrii tetradecyclis sulfas
Natrii tetradecyclis sulfas [INN-Latin]
Natrii tetradecylis sulfa
Niaproof 4
S.T.D
S.T.D.
STDS
 
STS
Sodium 2-methyl-7-ethylundecanol-4-sulfate
Sodium 7-ethyl-2-methyl-4-undecanol sulfate
Sodium myristyl sulfate
Sodium myristyl sulphate
Sodium tetradecyl sulphate
Sodium tetradecylsulfate
Sotradecol Sodium
Sulfuric acid, monotetradecyl ester, sodium salt
Sulfuric acid, myristyl ester, sodium salt
Tesapon K 14
Tetradecilsulfato sodico
Tetradecilsulfato sodico [INN-Spanish]
Tetradecyl hydrogen sulfate
Tetradecyl hydrogen sulphate
Tetradecyl sodium sulfate
Tetradecyl sodium sulphate
Tetradecyl sulfate
Tetradecyl sulfate de sodium
Tetradecyl sulfate de sodium [INN-French]
Tetradecyl sulfate, sodium salt
Tetradecyl sulfuric Acid
Tetradecyl sulphate
Texapon K 14
Trombavar
6
Paclitaxelapproved, vet_approvedPhase 4, Phase 3, Phase 2286433069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
7
Epinephrineapproved, vet_approvedPhase 498551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
8
Lidocaineapproved, vet_approvedPhase 41317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
9
PetrolatumapprovedPhase 4, Phase 2938009-03-8
Synonyms:
Multi-hydrocarbon
Paraffinum album
Paraffinum flavum
Petrolatum base
Petrolatum, white
 
Petrolatum,amber
Petrolatum,white
Petroleum jelly
Soft paraffin
White petrolatum
White, soft paraffin
Yellow soft paraffin
10
decanoic acidexperimentalPhase 4144334-48-52969
Synonyms:
1-Nonanecarboxylate
1-Nonanecarboxylic acid
Caprate
Capric acid
Caprinate
Caprinic acid
Caprynate
Caprynic acid
Decanoate
Decanoic acid
Decoate
Decoic acid
Decylate
 
Decylic acid
Emery 659
Lunac 10-95
Lunac 10-98
N-Caprate
N-Capric acid
N-Decanoate
N-Decanoic acid
N-Decoate
N-Decoic acid
N-Decylate
N-Decylic acid
Prifac 2906
Prifac 296
11Calcium, DietaryPhase 4, Phase 2, Phase 35713
12Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 323689
13Antineoplastic Agents, PhytogenicPhase 4, Phase 2, Phase 3, Phase 15602
14AnalgesicsPhase 4, Phase 2, Phase 311733
15Pharmaceutical SolutionsPhase 4, Phase 2, Phase 3, Phase 18192
16Anti-Infective AgentsPhase 4, Phase 2, Phase 3, Phase 122062
17AnestheticsPhase 49596
18Hormone AntagonistsPhase 4, Phase 3, Phase 213180
19Tranquilizing AgentsPhase 4, Phase 3, Phase 2, Phase 14265
20Psychotropic DrugsPhase 4, Phase 3, Phase 2, Phase 16430
21Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 213168
22HormonesPhase 4, Phase 3, Phase 214415
23HIV Protease InhibitorsPhase 4, Phase 3, Phase 25470
24Dipeptidyl-Peptidase IV InhibitorsPhase 4862
25Sitagliptin PhosphatePhase 4423
26Albumin-Bound PaclitaxelPhase 4, Phase 3, Phase 22864
27Antimitotic AgentsPhase 4, Phase 3, Phase 2, Phase 15657
28Antiparkinson AgentsPhase 4, Phase 21574
29Antifungal AgentsPhase 4, Phase 1, Phase 23696
30Neuroprotective AgentsPhase 4, Phase 21716
31Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 118340
32Protective AgentsPhase 4, Phase 3, Phase 2, Phase 17443
33Anti-Anxiety AgentsPhase 4, Phase 3, Phase 11885
34Central Nervous System DepressantsPhase 4, Phase 3, Phase 2, Phase 113403
35AnticonvulsantsPhase 4, Phase 32695
36AntiemeticsPhase 4, Phase 3, Phase 24022
37calcium channel blockersPhase 4, Phase 31985
38IncretinsPhase 41579
39Autonomic AgentsPhase 4, Phase 3, Phase 210150
40
protease inhibitorsPhase 4, Phase 3, Phase 25471
Synonyms:
 
protease inhibitors
41Gastrointestinal AgentsPhase 4, Phase 3, Phase 28402
42Hypnotics and SedativesPhase 4, Phase 12616
43Carbon fiberPhase 413
44GABA ModulatorsPhase 4, Phase 1904
45Hypoglycemic AgentsPhase 45896
46GABA AgentsPhase 4, Phase 11684
47HemostaticsPhase 41443
48RacepinephrinePhase 4985
49Respiratory System AgentsPhase 4, Phase 3, Phase 14997
50Vasoconstrictor AgentsPhase 42122

Interventional clinical trials:

(show top 50)    (show all 212)
idNameStatusNCT IDPhase
1Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for SurgeryUnknown statusNCT01431222Phase 4
2A Trial Comparing a Paclitaxel Eluting Stent With Biodegradable Polymer Versus a Bare Metal StentCompletedNCT00825279Phase 4
3PK Comparison of 6mg and 12mg EMSAM in Elderly vs. Non-ElderlyCompletedNCT00532116Phase 4
4Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 DiabetesCompletedNCT00978796Phase 4
5AngioSeal Versus Radial Approach in Acute Coronary SyndromeCompletedNCT01653587Phase 4
6Mobility Training Using a Bionic Knee Orthosis in Patients Chronic Post-Stroke: A Case SeriesCompletedNCT01499862Phase 4
7Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety DisorderCompletedNCT00624780Phase 4
8Frailty and Cognitive Function Assessment of TAVI PatientsRecruitingNCT02650388Phase 4
9Laser Ablation Versus Mechanochemical Ablation TrialRecruitingNCT02627846Phase 4
10The PARTNER TRIAL - Post Approval Study Part IIActive, not recruitingNCT02184442Phase 4
11Early Intervention With Lipid-Rich Barrier Cream in Infants at High Risk of AtopyNot yet recruitingNCT03089476Phase 4
12A Pilot Study Assessing EmSam in Bipolar DepressionTerminatedNCT00535262Phase 4
13RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVIWithdrawnNCT02010437Phase 4
14Star-Close Versus Angio-Seal for Femoral Artery HemostasisWithdrawnNCT00590356Phase 4
15Efficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary HypertensionUnknown statusNCT01637675Phase 2, Phase 3
16Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch MethodUnknown statusNCT01986361Phase 3
17Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue SarcomaUnknown statusNCT00334854Phase 3
18Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue SarcomaCompletedNCT01168791Phase 3
19High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Schizophrenia : a Randomized Controlled StudyCompletedNCT01022489Phase 2, Phase 3
20Safety, Tolerability and Efficacy of the Transdermal System in Elderly Subjects With Major DepressionCompletedNCT00285766Phase 3
21Phase 3 Study to Treat Patients With Soft Tissue SarcomasCompletedNCT02049905Phase 3
22Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other MalignancyCompletedNCT00716976Phase 3
23A Study For Pregabalin In Patients With FibromyalgiaCompletedNCT01387607Phase 3
24An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic PainCompletedNCT01202227Phase 3
25Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior TherapyCompletedNCT00753688Phase 3
26Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant ChemotherapyRecruitingNCT01710176Phase 3
27Preoperative vs Postoperative IMRT for Extremity/Truncal STSRecruitingNCT02565498Phase 3
28Role of Barrier Resection in Local Control for Extremity Recurrent Soft Tissue SarcomasRecruitingNCT02120768Phase 3
29Trial Comparing Trabectedin to the Best Supportive Care in Patients With SarcomaRecruitingNCT02672527Phase 3
30NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating and Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk WallRecruitingNCT02379845Phase 2, Phase 3
31Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's TypeRecruitingNCT02446132Phase 3
32A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)RecruitingNCT02213263Phase 3
33PALbociclib CoLlaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2 RecruitingNCT02513394Phase 3
34Study of Anlotinib in Patients With Soft Tissue Sarcoma(STS)(ALTER0203)Active, not recruitingNCT02449343Phase 2, Phase 3
35A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue SarcomaActive, not recruitingNCT02451943Phase 3
36Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast CancerActive, not recruitingNCT00878709Phase 3
37Randomized, Double-Blind, Multicenter, Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung CancerActive, not recruitingNCT02106546Phase 3
38Trabectedin Maintenance Post 1st-line in STSNot yet recruitingNCT02929394Phase 3
39BioVentrix Revivent TC™ System Clinical StudyNot yet recruitingNCT02931240Phase 2, Phase 3
40A Study to Provide Access to Trabectedin in Participants With Locally Advanced or Metastatic Soft Tissue Sarcoma Who Have Persistent or Recurrent Disease and Who Are Not Expected to Benefit From Currently Available Standard of Care TreatmentNo longer availableNCT00210665Phase 3
41Near Infrared Spectroscopy (NIRS) in Severe SepsisTerminatedNCT00167596Phase 2, Phase 3
42Randomized Double Blind Placebo Controlled Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic ArteriolopathTerminatedNCT02527213Phase 3
43Pregabalin Trial In HIV Neuropathic PainTerminatedNCT01145417Phase 3
44Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV NeuropathyTerminatedNCT01049217Phase 3
4512-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) SubjectsWithdrawnNCT01061372Phase 3
46Trofosfamide Versus Adriamycin in Elderly Patients With Soft Tissue Sarcoma (STS)Unknown statusNCT00204568Phase 2
47Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children.Unknown statusNCT01388179Phase 2
48Phase I-II Trial of Sorafenib in Combination With Ifosfamide in Soft Tissue SarcomaUnknown statusNCT00541840Phase 1, Phase 2
49A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-tissue SarcomaUnknown statusNCT00718484Phase 2
50Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue SarcomaUnknown statusNCT01514188Phase 2

Search NIH Clinical Center for Ichthyosis, X-Linked


Cochrane evidence based reviews: ichthyosis, x-linked

Genetic Tests for Ichthyosis, X-Linked

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Genetic tests related to Ichthyosis, X-Linked:

id Genetic test Affiliating Genes
1 Ichthyosis, X-Linked24 STS

Anatomical Context for Ichthyosis, X-Linked

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MalaCards organs/tissues related to Ichthyosis, X-Linked:

36
Skin, Eye

Publications for Ichthyosis, X-Linked

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Variations for Ichthyosis, X-Linked

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UniProtKB/Swiss-Prot genetic disease variations for Ichthyosis, X-Linked:

70
id Symbol AA change Variation ID SNP ID
1STSp.Ser341LeuVAR_007240rs137853167
2STSp.Trp372ArgVAR_007241rs137853165
3STSp.Cys446TyrVAR_007242rs137853166
4STSp.Trp372SerVAR_014020rs137853168
5STSp.Gly380ArgVAR_014021
6STSp.His444ArgVAR_014022rs137853169
7STSp.Gln560ProVAR_014023

Clinvar genetic disease variations for Ichthyosis, X-Linked:

5
id Gene Variation Type Significance SNP ID Assembly Location
1STSNM_ 000351.5(STS): c.1114T> A (p.Trp372Arg)SNVPathogenicrs137853165GRCh37Chr X, 7243397: 7243397
2STSNM_ 000351.5(STS): c.1337G> A (p.Cys446Tyr)SNVPathogenicrs137853166GRCh37Chr X, 7252107: 7252107
3STSNM_ 000351.5(STS): c.1022C> T (p.Ser341Leu)SNVPathogenicrs137853167GRCh37Chr X, 7223150: 7223150
4STSNM_ 000351.5(STS): c.1115G> C (p.Trp372Ser)SNVPathogenicrs137853168GRCh37Chr X, 7243398: 7243398
5STSNM_ 000351.5(STS): c.1331A> G (p.His444Arg)SNVPathogenicrs137853169GRCh37Chr X, 7252101: 7252101
6STSSTS, IVS8DS, G-T, +1SNVPathogenic
7STSNC_ 000023.11: g.(6499768_ 6517018)_ (8187691_ 8193324)deldeletionPathogenicGRCh38Chr X, 6499768: 8193324
8STSNC_ 000023.11: g.(6560264_ 6560764)_ (8187691_ 8193324)deldeletionPathogenicGRCh38Chr X, 6560264: 8193324
9STSNC_ 000023.11: g.(6674278_ 6675309)_ (7911900_ 7922037)deldeletionPathogenicGRCh38Chr X, 6674278: 7922037
10STSNC_ 000023.11: g.(6500268_ 6517018)_ (7739446_ 7762747)deldeletionPathogenicGRCh38Chr X, 6500268: 7762747

Copy number variations for Ichthyosis, X-Linked from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1264076X60000009500000Copy numberSteroid sulfatase deficiency
2266763Y19500000MicrodeletionSteroid sulfatase deficiency

Expression for genes affiliated with Ichthyosis, X-Linked

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Search GEO for disease gene expression data for Ichthyosis, X-Linked.

Pathways for genes affiliated with Ichthyosis, X-Linked

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GO Terms for genes affiliated with Ichthyosis, X-Linked

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Cellular components related to Ichthyosis, X-Linked according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00015339.7FLG, KRT10, TGM1
2endoplasmic reticulum lumenGO:00057889.2ARSH, STS, SUMF1

Biological processes related to Ichthyosis, X-Linked according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosphingolipid metabolic processGO:00066879.8ARSH, STS, SUMF1
2cornificationGO:00702689.7FLG, KRT10, TGM1
3keratinocyte differentiationGO:00302169.7FLG, KRT10, TGM1
4peptide cross-linkingGO:00181499.7FLG, KRT10, TGM1
5skin epidermis developmentGO:00987739.5FLG, KRT10
6post-translational protein modificationGO:00436879.4ARSH, STS, SUMF1

Molecular functions related to Ichthyosis, X-Linked according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of epidermisGO:00302809.9FLG, KRT10
2sulfuric ester hydrolase activityGO:00084849.8ARSH, STS

Sources for Ichthyosis, X-Linked

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet