Idiopathic Generalized Epilepsy malady

Disease Ontology: An epilepsy that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.⁶

MalaCards: Idiopathic Generalized Epilepsy, also known as epilepsy, idiopathic generalized, is related to temporal lobe epilepsy and myoclonus. An important gene associated with Idiopathic Generalized Epilepsy is KCNJ10 (potassium inwardly-rectifying channel, subfamily J, member 10), and among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Antiarrhythmic Pathway, Pharmacodynamics. The drugs primidone and anti-epileptic agent [epc] and the compounds Halazepam and Fludiazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Wikipedia: Idiopathic generalized epilepsy (IGE) is a group of epileptic disorders that are believed to have a...⁴⁴ more...

OMIM: 600669

Aliases & Descriptions:

idiopathic generalized epilepsy 6 43 epilepsy, idiopathic generalized 33 32 epilepsy, generalized 43

generalised epilepsy 6 epilepsy 43

Disease types for idiopathic generalized epilepsy family:

epilepsy, idiopathic generalized, susceptibility to, 8	epilepsy, idiopathic generalized 11
epilepsy, idiopathic generalized 9	epilepsy, idiopathic generalized 6
epilepsy, idiopathic generalized 1	epilepsy, idiopathic generalized 4
epilepsy, idiopathic generalized 5	epilepsy, idiopathic generalized 3
epilepsy, idiopathic generalized 2	epilepsy, idiopathic generalized 7
epilepsy, idiopathic generalized, 10

Diseases related to idiopathic generalized epilepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 401)

id	Related Disease	Score	Top Affiliating Genes
1	temporal lobe epilepsy	35.3	SCN1B, GRIK2, SLC1A2, GABBR1, GAD2
2	myoclonus	34.3	SCN2A, GABBR1, EFHC1, CSTB
3	autosomal dominant nocturnal frontal lobe epilepsy	33.2	CHRNB2, CHRNA4
4	generalized epilepsy with febrile seizures plus	32.7	GABRD, GABRG2, SCN1A, KCNQ2, SCN2A, SCN1B
5	focal epilepsy	32.4	GABRD, GABRG2, SCN1A
6	dravet syndrome	31.8	SCN1B, GABRG2, SCN1A, SCN2A
7	juvenile myoclonic epilepsy	31.7	GABRD, CACNB4, CLCN2, GABRA1
8	absence epilepsy	31.6	GABRB3, GABRA1, GABRG2, GABBR1, EFHC1, SLC1A2
9	merrf syndrome	31.2	SCN1B, CSTB, SCN1A, CHRNA4, GABRG2
10	benign epilepsy with centrotemporal spikes	30.4	SLC12A6, KCNQ3
11	seizure disorder	30.3	SCN1A, SCN2A, KCNQ2
12	severe myoclonic epilepsy of infancy (smei)	30.3	SCN1B, SCN1A, GABRG2, SCN2A
13	epilepsy with generalized tonic-clonic seizures	29.9	SCN2A, SCN1A
14	hemiplegic migraine	29.2	CACNA1A, ATP1A2, SCN1A
15	childhood absence epilepsy	29.2	CLCN2, CHRNA4, CACNA1G, CACNA1H, GABBR1, GABRG2
16	episodic ataxia	29.1	KCNQ3, CACNA1A, CACNB4, ATP1A2, SCN2A
17	myokymia with neonatal epilepsy	29.0	KCNQ2, KCNQ3
18	familial hemiplegic migraine	28.9	SCN1A, ATP1A2, CACNA1A
19	epilepsies, partial	28.7	SCN1A, GABRG2, CHRNA4
20	early myoclonic encephalopathy	28.6	SCN1A, CSTB
21	epilepsy syndrome	28.5	KCNJ10, SCN1B, CLCN2, SCN1A, ALDH5A1, CHRNA4
22	juvenile absence epilepsy	28.3	CACNA1A, ALDH5A1, GRIK2, CLCN2, CACNA1H, EFHC1
23	febrile seizures	28.3	GABRG2, CHRNB2, CHRNA4, SCN1A, KCNQ3, SCN1B
24	angelman syndrome	28.1	GAD2, GABRB3, GABRA1, GABRG2, CHRNA7
25	intellectual disability	27.8	ALDH5A1, CHRNA7, GABRB3, PAX6, KCNQ2, GABRD
26	status epilepticus	27.4	GABBR1, HCN2, HCN1, CACNA1A, ALDH5A1, SCN1A
27	long qt syndrome	26.8	ZACN, KCNQ2, SCN1B, KCNQ3
28	migraine with aura	26.8	CACNA1A, ATP1A2, SCN1A
29	ataxia	26.7	GRIK2, ATP1A2, SCN2A, GABRD, KCNJ10, CSTB
30	convulsions	26.6	GABBR1, SCN1A, CHRNA4, ATP1A2, CACNB4, CACNA1A
31	blindness	26.1	HP, CLCN2, PAX6, SCN1A, ATP1A2, MAOA
32	dementia	26.0	CHRNA4, SLC1A2, CSTB, CHRNA7, CHRNB2, MAOA
33	febrile convulsions	26.0	KCNQ2, KCNQ3, HCN2, GABRG2, CACNB4, SCN1A
34	cerebritis	26.0	SCN1B, CHRNA7, PAX6, CHRNB2, CHRNA4, ATP1A2
35	benign neonatal seizures	25.8	KCNQ2, KCNQ3
36	myokymia	25.6	CACNA1A, KCNQ3, KCNQ2
37	neuropathy	25.5	KCNQ2, GABBR1, SLC12A6, CSTB, CACNA1A, ATP1A2
38	mental retardation syndrome	25.0	PAX6, KCNQ2, MAOA, ATP1A2, ALDH5A1, CACNA1A
39	diabetes mellitus	25.0	CACNA1A, GAD2, TAP1, HP, CACNA1G, ATP1A2
40	benign familial neonatal-infantile seizures	24.9	KCNQ3, CHRNA4, KCNQ2, GABRG2, SCN1A, SCN1B
41	headache	24.8	ATP1A2, CACNA1A, MAOA, SCN1A, HP
42	down syndrome	24.7	CHRNA7, KCNQ2, GABRG2, ALDH5A1, CHRNA4, GABBR1
43	neurologic diseases	24.6	CACNA1A, HP, ATP1A2, CACNB4, GAD2, SLC4A3
44	mood disorder	23.9	GABRA1, SLC1A2, MAOA, GRIK2, GABRG2, GABBR1
45	seizures	23.0	GABRB3, GAD2, GABRA1, GABRG2, HCN1, HCN2
46	ischemia	22.7	PAX6, GABBR1, HP, CHRNA4, ATP1A2, GRIK2
47	bipolar disorder	22.3	CHRNB2, CHRNA4, GAD2, GABRB3, GABRA1, GABRG2
48	schizophrenia	21.2	CHRNB2, CHRNA7, KCNQ2, KCNJ10, KCNJ9, PAX6
49	neuronitis	20.3	CSTB, GABRD, GABBR1, EFHC1, SLC1A2, SLC12A6
50	episodic ataxia type 2	13.5	CACNB4, CACNA1A

Clinical features from OMIM: 600669

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anti-epileptic agent [epc], primidone

MalaCards organs/tissues related to idiopathic generalized epilepsy:

²²

MGI Mouse Phenotypes related to idiopathic generalized epilepsy:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	9.3	GABRB3, GABRA1, GABRD, SLC12A6, CACNB4, CHRNB2
2	vision/eye phenotype	MP:0005391	9.0	SLC4A3, CSTB, GLRA3, CACNB4, CHRNB2, SCN1B
3	muscle phenotype	MP:0005369	8.4	GAD2, EFHC1, SLC12A6, SLC4A3, CSTB, GLRB
4	no phenotypic analysis	MP:0003012	7.9	GAD2, GABRB3, GABRA1, CSTB, HCN1, GLRA3
5	integument phenotype	MP:0010771	7.9	HCN2, TAP1, SLC4A3, SLC12A6, GABBR1, HCN1
6	reproductive system phenotype	MP:0005389	7.6	SLC12A6, GABBR1, GABRD, GABRG2, GABRA1, GABRB3
7	homeostasis/metabolism phenotype	MP:0005376	6.5	CACNA1A, GLRB, HP, SLC4A3, GABBR1, GABRG2
8	growth/size phenotype	MP:0005378	6.0	CACNA1H, GLRB, HCN2, CSTB, SLC12A6, SLC1A2
9	mortality/aging	MP:0010768	5.5	GLRB, HP, HCN2, TAP1, SLC4A3, SLC1A2
10	nervous system phenotype	MP:0003631	3.9	CLCN2, CACNA1G, CACNB4, MAOA, GRM4, GRIK2
11	behavior/neurological phenotype	MP:0005386	3.3	GAD2, CACNB4, ALDH5A1, MAOA, GRM4, GRIK2

Articles related to idiopathic generalized epilepsy:

(show top 50)    (show all 61)

id	Title	Authors	Year	Affiliating Genes
1	Novel I+1 and I^2 GABAA receptor subunit mutations in f amilies with idiopathic generalized epilepsy. (21714819)	Lachance-Touchette P.... Cossette P.	2011	GABRG2, GABRA1
2	Screening of GABRB3 in French-Canadian families with idiopathic generalized epilepsy. (20550555)	Lachance-Touchette P.... Cossette P.	2010	GABRB3
3	Role of GRM4 in idiopathic generalized epilepsies ana lysed by genetic association and sequence analysis. (20338729)	Muhle H.... Sander T.	2010	GRM4
4	Dimorphism of TAP-1 gene in Caucasian with juvenile m yoclonic epilepsy and in Tunisian with idiopathic generalized epilepsies. (20141545)	Layouni S.... Dogui M.	2010	TAP1
5	Recurrent microdeletions at 15q11.2 and 16p13.11 pred ispose to idiopathic generalized epilepsies. (19843651)	de Kovel C.G.... Sander T.	2010	FOPNL, NPAP1
6	CLCN2 variants in idiopathic generalized epilepsy. (19710712)	Kleefuss-Lie A.... Lerche H.	2009	CLCN2
7	Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. (19191339)	Saint-Martin C.... Depienne C.	2009	CLCN2
8	Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes. (17167787)	Striano P.... Striano S.	2008	GAD2
9	Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. (17931874)	Tang B.... Escayg A.	2008	HCN2, HCN1
10	Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits. (17385675)	Lee C.C.... Tsai F.J.	2007	CHRNA4, CHRNB2
11	Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. (17696120)	Heron S.E.... Zamponi G.W.	2007	CACNA1H
12	Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. (16958040)	Lorenz S.... Sander T.	2007	KCNMB3
13	Lack of evidence for association between D2S124 and D2S111 polymorphisms of the SCN2A gene and idiopathic generalized epilepsy with generalized tonic clonic seizures. (17715289)	Volzone A.... Curatolo P.	2007	SCN2A
14	Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes. (16932951)	Stogmann E.... Zimprich A.	2006	CLCN2
15	No association of single nucleotide polymorphisms in the micro-opioid receptor subunit gene with idiopathic generalized epilepsy. (17054695)	Barratt C.... Makoff A.	2006	OPRM1
16	A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. (16565161)	Zhong X.... Agnew W.S.	2006	CACNA1H
17	Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity. (16406321)	Lorenz S.... Sander T.	2006	ALDH5A1
18	Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. (16205844)	Haider M.Z.... Al-Bloushi M.	2005	CHRNA4, CSTB, SCN1B
19	Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy. (15929039)	Tauer U.... Sander T.	2005	PPR1
20	Genetics of idiopathic generalized epilepsies. (16302872)	Gardiner M.	2005	ME2
21	CLCN2 and idiopathic generalized epilepsy. (15508929)	Heils A.	2005	CLCN2
22	Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. (16190936)	Lenzen K.P.... Sander T.	2005	ME2
23	No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. (15911117)	Lohoff F.W.... Buono R.J.	2005	ATP1A2, KCNJ10, KCNJ9
24	SCN1A mutation analysis in myoclonic astatic epilepsy and severe idiopathic generalized epilepsy of infancy with generalized tonic- clonic seizures. (15944908)	Ebach K.... Neubauer B.A.	2005	SCN1A
25	Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy. (16023832)	Lenzen K.P.... Sander T.	2005	GABRD
26	Seizures of idiopathic generalized epilepsies. (16302874)	Duron R.M.... Delgado-Escueta A.V.	2005	GABRG2, SCN1A, SCN1B
27	Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. (15852375)	Khosravani H.... Zamponi G.W.	2005	CACNA1H
28	Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. (15725393)	Lenzen K.P.... Sander T.	2005	KCNJ10
29	Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. (15252188)	Niemeyer M.I.... Cid L.P.	2004	CLCN2
30	Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism. (15490286)	Saccucci P.... Curatolo P.	2004	HP
31	Genetic variation of CACNA1H in idiopathic generalized epilepsy. (15048902)	Heron S.E.... Scheffer I.E.	2004	CACNA1H
32	Exploring new gene discoveries in idiopathic generalized epilepsy. (12752457)	Noebels J.L.	2003	ZACN
33	Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. (12612585)	Haug K.... Heils A.	2003	CLCN2
34	Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. (12399075)	Sander T.... Nurnberg P.	2002	SLC4A3
35	Failure to replicate an allelic association between an exon 8 polymorphism of the human alpha(1A) calcium channel gene and common syndromes of idiopathic generalized epilepsy. (12049805)	Sander T.... Nurnberg P.	2002	CACNA1A
36	Genetic variation of the human glycine receptor subun it genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies . (11496371)	Sobetzko D.... Becker C.M.	2001	GLRB, GLRA3
37	Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy. (11342703)	Chioza B.... Makoff A.J.	2001	CACNA1A
38	Mutation analysis of the potassium chloride cotransporter KCC3 (SLC12A6) in rolandic and idiopathic generalized epilepsy. (11325574)	Steinlein O.K.... Mount D.B.	2001	SLC12A6
39	The voltage-gated sodium channel gene SCN2A and idiopathic generalized epilepsy. (11738931)	Haug K.... Heils A.	2001	SCN2A
40	Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (10970730)	Haug K.... Heils A.	2000	ARC
41	Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy. (10924870)	Sander T.... Hoehe M.R.	2000	SLC1A2
42	Coding and noncoding variation of the human calcium-channel beta4- subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. (10762541)	Escayg A.... Meisler M.H.	2000	CACNB4
43	No evidence for association between the KCNQ3 gene and susceptibility to idiopathic generalized epilepsy. (10996506)	Haug K.... Heils A.	2000	KCNQ3, KCNQ2
44	Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy. (10463851)	Sander T.... Janz D.	1999	PAX6
45	Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. (10402495)	Sander T.... Riess O.	1999	GABBR1
46	The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. (10363917)	Steinlein O.K.... Sander T.	1999	KCNQ2
47	Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. (9933300)	Peters H.C.... Riess O.	1998	GABBR1
48	Possible association of a silent polymorphism in the neuronal nicotinic acetylcholine receptor subunit alpha4 with common idiopathic generalized epilepsies. (9259383)	Steinlein O.... Propping P.	1997	CHRNA4
49	Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies. (7675232)	Sander T.... Sailer U.	1995	GRIK2
50	Mapping of genes predisposing to idiopathic generalized epilepsy. (8528209)	Zara F.... Pandolfo M.	1995	EGI

Genes related to idiopathic generalized epilepsy according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	11.1	Summaries, Publications
2	ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial	11.1	Summaries, Publications
3	CACNB4	calcium channel, voltage-dependent, beta 4 subunit	11.1	Summaries, Publications
4	PPR1	Photoparoxysmal response 1	11.0	Publications
5	EGI	epilepsy, generalized, idiopathic	11.0	Publications
6	CLCN2	chloride channel, voltage-sensitive 2	11.0	Publications
7	ARC	activity-regulated cytoskeleton-associated protein	11.0	Publications
8	KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	11.0	Publications
9	GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	11.0	Publications
10	ZACN	zinc activated ligand-gated ion channel	11.0	Publications
11	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.0	Publications
12	SLC4A3	solute carrier family 4, anion exchanger, member 3	11.0	Publications
13	FOPNL	FGFR1OP N-terminal like	11.0	Publications
14	EFHC1	EF-hand domain (C-terminal) containing 1	11.0	Publications
15	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3	11.0	Publications
16	KCNK12	potassium channel, subfamily K, member 12	11.0	Publications
17	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.0	Publications
18	CSTB	cystatin B (stefin B)	11.0	Publications
19	CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	11.0	Publications
20	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
21	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	11.0	Publications
22	HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	11.0	Publications
23	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
24	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	11.0	Publications
25	KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	11.0	Publications
26	ALDH5A1	aldehyde dehydrogenase 5 family, member A1	11.0	Publications
27	CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	11.0	Publications
28	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0	Publications
29	PAX6	paired box 6	11.0	Publications
30	GLRB	glycine receptor, beta	11.0	Publications
31	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	11.0	Publications
32	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
33	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6	11.0	Publications
34	SCN1A	sodium channel, voltage-gated, type I, alpha subunit	11.0	Publications
35	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11.0	Publications
36	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0	Publications
37	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	11.0	Publications
38	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0	Publications
39	GLRA3	glycine receptor, alpha 3	11.0	Publications
40	GRM4	glutamate receptor, metabotropic 4	11.0	Publications
41	HP	haptoglobin	11.0	Publications
42	CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	11.0	Publications
43	MAOA	monoamine oxidase A	11.0	Publications
44	HCN1	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	11.0	Publications
45	KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3	11.0	Publications
46	GRIK2	glutamate receptor, ionotropic, kainate 2	11.0	Publications
47	NPAP1	nuclear pore associated protein 1	10.2	Publications
48	OPRM1	opioid receptor, mu 1	9.4	Publications

Pathways related to idiopathic generalized epilepsy according to GeneDecks:

(show all 39)

id	Pathway	Score	Top Affiliating Genes
1	Postsynaptic nicotinic acetylcholine receptors38	10.3	CHRNA4, CHRNB2
2	Antiarrhythmic Pathway, Pharmacodynamics34	10.2	HCN2, CACNA1H, CACNA1G, SCN1B
3	nNOS Signaling in Skeletal Muscle36	10.2	CACNA1H, CACNA1A, CACNA1G, CACNB4
4	DREAM Repression and Dynorphin Expression36	10.2	CACNA1H, CACNA1A, CACNA1G, CACNB4
5	Hepatic ABC Transporters36	10.2	SLC4A3, ATP1A2, KCNK12, CLCN2
6	Fc-Gamma-RIIB Signaling in B-Cells36	10.2	CACNA1H, CACNA1A, CACNA1G, CACNB4
7	Fc-GammaR Pathway36	10.1	CACNB4, CACNA1G, CACNA1A, CACNA1H
8	CCR5 Pathway in Macrophages36	10.1	CACNA1H, CACNA1A, CACNA1G, CACNB4
9	G-Beta Gamma Signaling36	10.1	CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNJ9
10	BMP Pathway36	10.1	CACNA1H, CACNA1A, CACNA1G, CACNB4
11	Sweet Taste Signaling36	10.1	CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNK12
12	Potassium transporters- inward current10	10.1	HCN2, HCN1, KCNJ10, KCNJ9
13	Caspase Cascade36	10.1	CACNA1H, CACNA1A, CACNA1G, CACNB4
14	Melatonin Signaling36	10.0	CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNK12
15	Transcription CREB pathway10	10.0	CACNB4, CACNA1G, CACNA1A, CACNA1H
16	GHRH Signaling36	9.9	CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
17	Fc-EpsilonRI Pathway36	9.9	CACNA1H, CACNA1A, CACNA1G, CACNB4
18	Cellular Effects of Sildenafil36	9.9	KCNK12, CACNB4, CACNA1G, CACNA1A, CACNA1H
19	Sodium channels and transporters- inward current10	9.9	HCN2, HCN1, SCN1A, SCN2A
20	PDGF Pathway36	9.9	CACNA1H, CACNA1A, CACNA1G, CACNB4
21	Calpain Protease Regulates Cellular Mechanics36	9.9	CACNB4, CACNA1G, CACNA1A, CACNA1H
22	GABA signaling in brain10	9.8	GAD2, GABRB3, GABRA1, GABRG2, GABRD, GABBR1
23	Androgen Signaling36	9.8	CACNA1H, CACNA1A, CACNA1G, CACNB4
24	PKA Signaling36	9.7	CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
25	Axon guidance38	9.7	CACNA1H, CACNA1G, CACNB4, SCN1B, KCNQ3, KCNQ2
26	Calcium channels10	9.7	CACNA1H, CACNA1A, CACNA1G, CHRNA4, CHRNB2, CHRNA7
27	Activation of cAMP-Dependent PKA36	9.7	CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
28	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.6	CACNA1A, CACNB4, KCNQ3, KCNQ2, KCNJ10, KCNJ9
29	cAMP Pathway36	9.6	CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
30	Celecoxib Pathway, Pharmacodynamics34	9.6	CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNQ3, KCNQ2
31	Transcription_CREB pathway41	9.6	CACNA1H, CACNA1A, CACNA1G, CACNB4
32	Neuronal System38	9.5	GABRB3, GABRA1, GABRG2, HCN2, HCN1, ALDH5A1
33	Glutamic acid signaling10	9.4	GAD2, SLC1A2, GRM4, GRIK2
34	Cholinergic synapse20	9.3	CACNA1A, CHRNA4, CHRNB2, CHRNA7, KCNQ3, KCNQ2
35	Sperm Motility36	9.2	GABRB3, GABRA1, GABRG2, GABRD, HCN2, HCN1
36	Synaptic transmission- ion currents10	9.2	KCNJ9, CACNA1H, CACNA1A, CACNA1G, SCN1A, SCN2A
37	CREB Pathway36	9.1	CACNA1H, CACNA1A, CACNA1G, CACNB4, GRM4, GRIK2
38	Intracellular Calcium Signaling36	9.0	CACNA1H, CACNA1A, CACNA1G, CACNB4, GRIK2, CHRNA4
39	Neuroactive ligand-receptor interaction20	8.0	GABRB3, GABRA1, GABRG2, GABRD, GABBR1, GLRB

Compounds related to idiopathic generalized epilepsy according to GeneDecks:

(show top 50)    (show all 84)

id	Compound	Score	Top Affiliating Genes
1	Halazepam9 9	11.2	GABRB3, GABRA1, GABRG2, GABRD
2	Fludiazepam9 9	11.2	GABRD, GABRG2, GABRA1, GABRB3
3	Cinolazepam9 9	11.2	GABRD, GABRG2, GABRA1, GABRB3
4	(+)-bicuculline42	10.2	GABRD, GABRG2, GABRA1, GABRB3
5	sr 95531 hydrobromide42	10.2	GABRD, GABRG2, GABRA1, GABRB3
6	Prazepam9 9	11.2	GABRB3, GABRA1, GABRG2, GABRD
7	Adinazolam9 9	11.2	GABRB3, GABRA1, GABRG2, GABRD
8	estazolam32 9 9	12.2	GABRB3, GABRA1, GABRG2, GABRD
9	quazepam32 9 9	12.1	GABRB3, GABRA1, GABRG2, GABRD
10	muscimol32 42	11.1	GABRB3, GABRA1, GABRG2, GABRD, GABBR1
11	Clotiazepam9 9	11.1	GABRB3, GABRA1, GABRG2, GABRD
12	Clorazepate9 9	11.1	GABRB3, GABRA1, GABRG2, GABRD
13	nitrazepam32 9 9	12.1	SCN1A, GABRD, GABRG2, GABRA1, GABRB3
14	Oxazepam9 9	11.1	GABRB3, GABRA1, GABRG2, GABRD
15	diazepam32 34 9 9	13.0	GABRB3, GABRA1, GABRG2, GABRD, GABBR1
16	flurazepam32 9 9	12.0	GABRB3, GABRA1, GABRG2, GABRD
17	clobazam34 32 9 9	13.0	GABRB3, GABRA1, GABRG2, GABRD
18	Temazepam9 9	10.9	GABRB3, GABRA1, GABRG2, GABRD
19	bromazepam32 9 9	11.9	GABRB3, GABRA1, GABRG2, GABRD, MAOA
20	lorazepam32 34 9 9	12.9	GABRB3, GABRA1, GABRG2, GABRD
21	triazolam32 9 9	11.9	GABRD, GABRG2, GABRA1, GABRB3
22	alprazolam32 9 9	11.8	GABRB3, GABRA1, GABRG2, GABRD, MAOA
23	chlordiazepoxide32 9 9	11.8	GABRB3, GABRA1, GABRG2, GABRD
24	clonazepam32 9 9	11.7	GABRB3, GABRA1, GABRG2, GABRD, GABBR1, MAOA
25	zonisamide32 9 9	11.7	CACNA1H, CACNA1G, MAOA, SCN1A, SCN2A, SCN1B
26	Heptabarbital9 9	10.6	CHRNA4, CHRNA7, GRIK2, GABRA1
27	Butalbital9 9	10.6	GABRA1, GRIK2, CHRNA4, CHRNA7
28	Barbituric acid derivative9 9	10.6	GABRA1, GRIK2, CHRNA4, CHRNA7
29	Metharbital9 9	10.6	CHRNA7, CHRNA4, GRIK2, GABRA1
30	Talbutal9 9	10.6	CHRNA7, CHRNA4, GRIK2, GABRA1
31	Aprobarbital9 9	10.6	CHRNA7, CHRNA4, GRIK2, GABRA1
32	Barbital9 9	10.6	CHRNA7, CHRNA4, GRIK2, GABRA1
33	Butabarbital9 9	10.6	CHRNA7, CHRNA4, GABRA1, GRIK2
34	Butethal9 9	10.6	GABRA1, GRIK2, CHRNA4, CHRNA7
35	Methylphenobarbital9 9	10.6	GABRA1, GRIK2, CHRNA4, CHRNA7
36	amobarbital32 9 9	11.6	GABRA1, GRIK2, CHRNA4, CHRNA7
37	Secobarbital9 9	10.6	GABRA1, GRIK2, CHRNA4, CHRNA7
38	primidone32 9 9	11.5	GABRA1, GRIK2, CHRNA4, CHRNA7
39	pentobarbital32 9 9	11.5	GABRA1, GABBR1, GRIK2, CHRNA4, CHRNA7
40	hexobarbital32 9 9	11.5	GABRA1, GRIK2, CHRNA4, CHRNA7
41	thiopental32 9 9	11.4	GABRA1, GRIK2, CHRNA4, CHRNA7
42	chlorine32 18	10.3	GABRB3, GABRA1, GABRG2, GABRD, SLC12A6, HCN2
43	4-aminopyridine32 42	10.0	GABBR1, CACNA1A, KCNQ3, KCNQ2, KCNMB3
44	acetylcholine32 9 18 9	11.7	GAD2, GABBR1, CACNA1A, CHRNA4, CHRNB2, CHRNA7
45	potassium32 9 18 9	11.4	ZACN, ATP1A2, CACNA1A, HCN2, GABBR1, GABRG2
46	nmda32 42	9.2	GAD2, GABBR1, SLC1A2, GLRB, MAOA, GRM4
47	gaba32 42	8.7	GAD2, GABRB3, GABRA1, GABRG2, GABBR1, SLC1A2
48	sodium32 18	8.5	CLCN2, GABRG2, SLC1A2, HCN2, HCN1, HP
49	glutamate32	7.1	GAD2, GABBR1, SLC1A2, TAP1, HP, CACNA1A
50	calcium32 9 18 9	10.0	GAD2, GABBR1, EFHC1, SLC1A2, OPRM1, CACNA1H

Cellular components related to idiopathic generalized epilepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated calcium channel complex	GO:005891	9.9	CACNB4, CACNA1G, CACNA1A, CACNA1H
2	voltage-gated sodium channel complex	GO:001518	9.9	SCN1B, SCN2A, SCN1A
3	node of Ranvier	GO:033268	9.6	SCN2A, KCNQ3, KCNQ2
4	voltage-gated potassium channel complex	GO:008076	9.5	KCNMB3, KCNQ2, KCNQ3, HCN2
5	acetylcholine-gated channel complex	GO:005892	9.5	CHRNA4, CHRNB2, CHRNA7
6	chloride channel complex	GO:034707	9.4	GABRB3, GABRA1, GABRG2, GABRD, GLRB, GLRA3
7	postsynaptic membrane	GO:045211	7.9	CHRNA7, GABRB3, GABRA1, GABRG2, GABRD, GABBR1
8	cell junction	GO:030054	7.7	GABRD, GABRG2, GABRA1, GABRB3, GAD2, GABBR1
9	integral to plasma membrane	GO:005887	7.4	SLC4A3, GABBR1, GABRD, GABRG2, GABRA1, GABRB3
10	plasma membrane	GO:005886	4.2	OPRM1, HCN2, HCN1, GLRB, GLRA3, SLC4A3

Biological processes related to idiopathic generalized epilepsy according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission, GABAergic	GO:051932	10.1	GABRA1, GABRG2
2	adult walking behavior	GO:007628	10.1	GLRB, CACNA1A, CACNB4, KCNJ10
3	membrane depolarization	GO:051899	10.0	CACNA1A, CACNB4, CHRNA4, CHRNB2, SCN1B
4	gamma-aminobutyric acid signaling pathway	GO:007214	10.0	GABRA1, GABRG2, GABBR1, CACNA1A, CACNB4
5	regulation of membrane potential	GO:042391	9.9	HCN2, GLRB, CACNA1H, CACNA1G, CHRNA4
6	learning	GO:007612	9.9	CHRNB2, ARC, GRM4
7	response to nicotine	GO:035094	9.9	GABBR1, CHRNA4, CHRNB2, CHRNA7
8	cognition	GO:050890	9.9	CHRNA4, CHRNB2, CHRNA7
9	gamma-aminobutyric acid secretion	GO:014051	9.9	CACNA1A, CACNB4
10	synaptic transmission, glutamatergic	GO:035249	9.5	GRIK2, CACNB4, CACNA1A
11	ion transmembrane transport	GO:034220	9.5	GABRB3, GABRA1, GABRG2, GLRB, GLRA3, ATP1A2
12	neurotransmitter secretion	GO:007269	9.4	GRM4, MAOA, ALDH5A1, GAD2
13	ion transport	GO:006811	9.3	SLC1A2, SLC12A6, SLC4A3, GLRB, CHRNA4, CHRNB2
14	axon guidance	GO:007411	9.3	CACNA1H, CACNA1G, CACNB4, SCN1B, KCNQ3, KCNQ2
15	potassium ion transport	GO:006813	9.0	SLC12A6, HCN1, ATP1A2, KCNQ3, KCNQ2, KCNMB3
16	transport	GO:006810	9.0	GABRB3, GABRA1, GABRG2, GABRD, SLC4A3, CACNA1H
17	transmembrane transport	GO:055085	8.9	GABRB3, GABRA1, GABRG2, SLC1A2, SLC12A6, SLC4A3
18	synaptic transmission	GO:007268	4.6	KCNJ9, CACNA1A, GLRA3, GLRB, HCN1, HCN2

Molecular functions related to idiopathic generalized epilepsy according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	GABA-A receptor activity	GO:004890	10.1	GABRB3, GABRA1, GABRG2, GABRD
2	extracellular-glycine-gated chloride channel activity	GO:016934	10.0	GLRA3, GLRB
3	acetylcholine receptor activity	GO:015464	9.9	CHRNA7, CHRNB2, CHRNA4
4	acetylcholine binding	GO:042166	9.9	CHRNA7, CHRNB2, CHRNA4
5	low voltage-gated calcium channel activity	GO:008332	9.9	CACNA1G, CACNA1H
6	acetylcholine-activated cation-selective channel activity	GO:004889	9.8	CHRNA4, CHRNB2, CHRNA7
7	chloride channel activity	GO:005254	9.8	GABRD, GABRG2, GABRA1, GABRB3
8	extracellular ligand-gated ion channel activity	GO:005230	9.7	ZACN, GLRA3, GABRD, GABRG2, GABRA1, GABRB3
9	potassium channel activity	GO:005267	9.4	KCNK12, KCNQ2, KCNQ3, HCN1
10	voltage-gated potassium channel activity	GO:005249	9.3	HCN2, HCN1, KCNQ3, KCNQ2