MCID: IDP010
MIFTS: 59

Idiopathic Generalized Epilepsy malady

Summaries for Idiopathic Generalized Epilepsy

About this section
Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An epilepsy that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.

MalaCards: Idiopathic Generalized Epilepsy, also known as epilepsy, idiopathic generalized, is related to epilepsy syndrome and juvenile myoclonic epilepsy. An important gene associated with Idiopathic Generalized Epilepsy is ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial), and among its related pathways are Inwardly rectifying K+ channels and Activation of GABAB receptors. The compounds p1075 and levcromakalim have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and thalamus, and related mouse phenotypes are vision/eye and behavior/neurological.

Wikipedia:63 Idiopathic generalized epilepsy (IGE) is a group of epileptic disorders that are believed to have a... more...

Description from OMIM:46 600669

Aliases & Classifications for Idiopathic Generalized Epilepsy

About this section
Sources:
8Disease Ontology, 22GTR, 10DISEASES, 60UMLS, 46OMIM, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

idiopathic generalized epilepsy 8 22 10 60
epilepsy, idiopathic generalized 46 44
epilepsy, generalized 60
generalised epilepsy 8


External Ids:

Disease Ontology8 DOID:1827
NCIt39 C3021
MeSH34 D004829

Related Diseases for Idiopathic Generalized Epilepsy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Idiopathic Generalized Epilepsy family:

Epilepsy, Idiopathic Generalized, Susceptibility to, 8 Epilepsy, Idiopathic Generalized, 10
Epilepsy, Idiopathic Generalized 9 Epilepsy, Idiopathic Generalized 11
Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized 3
Epilepsy, Idiopathic Generalized 5 Epilepsy, Idiopathic Generalized 4
Epilepsy, Idiopathic Generalized 2 Epilepsy, Idiopathic Generalized 7
Epilepsy, Idiopathic Generalized 6

Diseases related to Idiopathic Generalized Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy syndrome31.0CACNB4, CSTB, SCN1B, GABRG2, ZACN, HCN2
2juvenile myoclonic epilepsy30.8CHRNA4, GABRG2
3childhood absence epilepsy30.5GABRG2, CHRNA4, HCN2
4focal epilepsy30.4CHRNA4, GABRG2
5juvenile absence epilepsy30.4CLCN2, GABRG2
6frontal lobe epilepsy30.3CHRNA4, GABRG2, SCN1B
7epilepsy with generalized tonic-clonic seizures10.4
8status epilepticus10.4
9neuronitis10.4
10epilepsy, idiopathic generalized, susceptibility to, 810.4
11temporal lobe epilepsy10.3
12cerebritis10.3
13visual epilepsy10.3
1415q13.3 microdeletion10.3
15extratemporal epilepsy10.2
16epilepsy, idiopathic generalized, 1010.2
17epilepsy, idiopathic generalized, suscpetibility to, 1210.2
18epilepsy, juvenile myoclonic 610.2
19epilepsy, idiopathic generalized 910.2
20epilepsy, idiopathic generalized 1110.2
21epilepsy, idiopathic generalized 110.2
22epilepsy, idiopathic generalized 310.2
23epilepsy, idiopathic generalized 510.2
24epilepsy, idiopathic generalized 410.2
25epilepsy, idiopathic generalized 210.2
26epilepsy, idiopathic generalized 710.2
27epilepsy, idiopathic generalized 610.2
28epilepsy, generalized, with febrile seizures plus, type 310.1
29episodic ataxia10.1
30obsessive-compulsive disorder10.1
31adult syndrome10.1
32apraxia10.1
33long qt syndrome10.1
34schizophrenia10.1
35photosensitive epilepsy10.1
36epilepsy, childhood absence, susceptibility to, 210.1
37epilepsy, generalized, with febrile seizures plus, type 510.1
38epilepsy, juvenile myoclonic 810.1
39epilepsy, juvenile myoclonic 510.1
40jeavons syndrome10.1
41epilepsy, generalized, with febrile seizures plus, type 410.0
42epilepsy, generalized, with febrile seizures plus, type 210.0
43epilepsy, generalized, with febrile seizures plus, type 710.0
44epilepsy, generalized, with febrile seizures plus, type 610.0
45epilepsy, generalized, with febrile seizures plus, type 110.0
46porphyria cutanea tarda10.0
47good syndrome10.0
48primary ciliary dyskinesia10.0
49insulinoma10.0
50chromosomal disease10.0

Graphical network of the top 20 diseases related to Idiopathic Generalized Epilepsy:



Diseases related to idiopathic generalized epilepsy

Clinical Features for Idiopathic Generalized Epilepsy

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

600669

Clinical synopsis from OMIM:

600669

Drugs & Therapeutics for Idiopathic Generalized Epilepsy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Idiopathic Generalized Epilepsy

Drug clinical trials:

Search ClinicalTrials for Idiopathic Generalized Epilepsy

Search NIH Clinical Center for Idiopathic Generalized Epilepsy

Search CenterWatch for Idiopathic Generalized Epilepsy

Genetic Tests for Idiopathic Generalized Epilepsy

About this section
Sources:
22GTR
See all sources

Genetic tests related to Idiopathic Generalized Epilepsy:

id Genetic test Affiliating Genes
1 Idiopathic Generalized Epilepsy22

Anatomical Context for Idiopathic Generalized Epilepsy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Idiopathic Generalized Epilepsy:

32
Brain, Cortex, Thalamus, Temporal lobe, Cerebellum, Occipital lobe

Animal Models for Idiopathic Generalized Epilepsy or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Idiopathic Generalized Epilepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2CACNB4, CSTB, SCN1B, CLCN2, SLC4A3, KCNJ10
2MP:00053869.8SLC4A3, KCNJ9, KCNJ10, CACNB4, CSTB, SCN1B
3MP:00036319.6SCN1B, CSTB, CACNB4, KCNJ10, KCNJ9, GABRD

Publications for Idiopathic Generalized Epilepsy

About this section
Sources:
50PubMed
See all sources

Articles related to Idiopathic Generalized Epilepsy:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Neuropsychological and psychiatric outcomes in poorly controlled idiopathic generalized epilepsy. (23832134)
2013
2
A comment on idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India. (24101843)
2013
3
Natural evolution from idiopathic photosensitive occipital lobe epilepsy to idiopathic generalized epilepsy in an untreated young patient. (23815968)
2013
4
The electroencephalogram of idiopathic generalized epilepsy. (22150583)
2012
5
Defective visual inhibition in photosensitive idiopathic generalized epilepsy. (22332790)
2012
6
EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes. (22240326)
2012
7
Distinct white matter abnormalities in different idiopathic generalized epilepsy syndromes. (22092238)
2011
8
Novel I+1 and I^2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy. (21714819)
2011
9
The effective and ethical use of voluntary induction of psychogenic drop attacks in a patient with idiopathic generalized epilepsy. (20236869)
2010
10
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. (19843651)
2010
11
High-density SNP screen of sodium channel genes by haplotype tagging and DNA pooling for association with idiopathic generalized epilepsy. (20041941)
2010
12
Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. (20502679)
2010
13
CLCN2 variants in idiopathic generalized epilepsy. (19710712)
2009
14
Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? (19786369)
2009
15
Eyelid myoclonia with absences (Jeavons syndrome): a well-defined idiopathic generalized epilepsy syndrome or a spectrum of photosensitive conditions? (19469840)
2009
16
Psychiatric comorbidity in adult patients with idiopathic generalized epilepsy. (18353731)
2008
17
Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. (18285535)
2008
18
Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes. (17167787)
2008
19
Abnormal response of motor cortex to photic stimulation in idiopathic generalized epilepsy. (18627417)
2008
20
Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. (17625106)
2007
21
Characteristic distribution of interictal brain electrical activity in idiopathic generalized epilepsy. (17381440)
2007
22
Typical absence epilepsy presenting prior to age of 3 years: an uncommon form of idiopathic generalized epilepsy. (17500018)
2007
23
'Learning difficulties in children with epilepsy with idiopathic generalized epilepsy and well-controlled seizures'. (17979868)
2007
24
Lack of evidence for association between D2S124 and D2S111 polymorphisms of the SCN2A gene and idiopathic generalized epilepsy with generalized tonic clonic seizures. (17715289)
2007
25
An association between type 1 diabetes and idiopathic generalized epilepsy. (16566023)
2006
26
Regional effects of lamotrigine on cerebral glucose metabolism in idiopathic generalized epilepsy. (16966506)
2006
27
Status epilepticus in idiopathic generalized epilepsy. (16650150)
2006
28
Management guidelines for children with idiopathic generalized epilepsy. (16302884)
2005
29
Sleep architecture in children with idiopathic generalized epilepsy. (15660775)
2005
30
Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature. (16359472)
2005
31
The coexistence of idiopathic generalized epilepsy and partial epilepsy. (15144435)
2004
32
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. (15252188)
2004
33
Biparental inheritance in idiopathic generalized epilepsy. (15461686)
2004
34
Idiopathic Generalized Epilepsy. (15043806)
2004
35
fMRI activation during spike and wave discharges in idiopathic generalized epilepsy. (15033899)
2004
36
Exploration of a putative susceptibility locus for idiopathic generalized epilepsy on chromosome 8p12. (12581227)
2003
37
Characterization of a 6p21 translocation breakpoint in a family with idiopathic generalized epilepsy. (14643000)
2003
38
No evidence for a susceptibility locus for idiopathic generalized epilepsy on chromosome 18q21.1. (12210286)
2002
39
The voltage-gated sodium channel gene SCN2A and idiopathic generalized epilepsy. (11738931)
2001
40
The voltage-gated sodium channel beta2-subunit gene and idiopathic generalized epilepsy. (10976944)
2000
41
Coding and noncoding variation of the human calcium-channel beta4- subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. (10762541)
2000
42
Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy. (10463851)
1999
43
The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. (10363917)
1999
44
Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes. (9762955)
1998
45
Idiopathic generalized epilepsy of late onset. (9888493)
1998
46
Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. (9933300)
1998
47
Replication analysis of a putative susceptibility locus (EGI) for idiopathic generalized epilepsy on chromosome 8q24. (9670899)
1998
48
Wavelength specificity of photoparoxysmal responses in idiopathic generalized epilepsy. (7588452)
1995
49
Disturbance of visual information processing in temporal lobe epilepsy: in comparison with idiopathic generalized epilepsy. (8271589)
1993
50
Gene mapping in the idiopathic generalized epilepsies: juvenile myoclonic epilepsy, childhood absence epilepsy, epilepsy with grand mal seizures, and early childhood myoclonic epilepsy. (2121470)
1990

Genetic Variations for Idiopathic Generalized Epilepsy

About this section

Expression for genes affiliated with Idiopathic Generalized Epilepsy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Idiopathic Generalized Epilepsy

Search GEO for disease gene expression data for Idiopathic Generalized Epilepsy.

Pathways for genes affiliated with Idiopathic Generalized Epilepsy

About this section
Sources:
53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Idiopathic Generalized Epilepsy

About this section
Sources:
59Tocris Bioscience, 11DrugBank, 28IUPHAR, 44Novoseek, 24HMDB, 49PharmGKB
See all sources

Compounds related to Idiopathic Generalized Epilepsy according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1p10755910.8KCNJ9, KCNJ10
2levcromakalim5910.8KCNJ9, KCNJ10
3tertiapin-q5910.8KCNJ9, KCNJ10
4Cinolazepam1110.8GABRG2, GABRD
5Halazepam1110.7GABRG2, GABRD
6Fludiazepam1110.7GABRG2, GABRD
7(+)-bicuculline5910.7GABRD, GABRG2
8(-)-bicuculline methochloride5910.7GABRD, GABRG2
9(-)-bicuculline methiodide5910.7GABRD, GABRG2
10sr 95531 hydrobromide5910.7GABRD, GABRG2
11zn2+2810.7ZACN, CLCN2
12Prazepam1110.7GABRD, GABRG2
13estazolam44 1111.7GABRG2, GABRD
14Adinazolam1110.7GABRG2, GABRD
15quazepam44 1111.7GABRG2, GABRD
16chlorine44 2411.7GABRD, GABRG2, HCN2, CLCN2
17Clotiazepam1110.7GABRD, GABRG2
18Clorazepate1110.7GABRG2, GABRD
19bromazepam44 1111.6GABRD, GABRG2
20nitrazepam44 1111.6GABRD, GABRG2
21Temazepam1110.6GABRD, GABRG2
22lorazepam44 49 1112.6GABRD, GABRG2
23sodium44 2411.6SCN1B, GABRG2, ZACN, CHRNA4, HCN2, CLCN2
24flurazepam44 1111.6GABRD, GABRG2
25oxazepam49 1111.6GABRD, GABRG2
26clobazam44 49 1112.5GABRD, GABRG2
27potassium44 11 2412.5HCN2, KCNJ9, KCNMB3, SCN1B, GABRG2, ZACN
28chlordiazepoxide44 1111.5GABRD, GABRG2
29tbps44 2811.4GABRD, GABRG2
30clonazepam44 1111.4GABRD, GABRG2
31alprazolam44 1111.4GABRG2, GABRD
32muscimol44 59 2812.3GABRG2, GABRD
33triazolam44 1111.1GABRG2, GABRD

GO Terms for genes affiliated with Idiopathic Generalized Epilepsy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Idiopathic Generalized Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.3CHRNA4, ARC, GABRG2, GABRD
2postsynaptic membraneGO:04521110.2CHRNA4, ZACN, ARC, GABRG2, GABRD
3chloride channel complexGO:03470710.0GABRD, GABRG2, CLCN2
4plasma membraneGO:0058869.8CACNB4, KCNMB3, KCNJ10, KCNJ9, GABRG2, ARC

Biological processes related to Idiopathic Generalized Epilepsy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1membrane depolarizationGO:05189910.4CHRNA4, SCN1B, CACNB4
2adult walking behaviorGO:00762810.4CACNB4, KCNJ10
3neuronal action potential propagationGO:01922710.4SCN1B, CACNB4
4transportGO:00681010.3CACNB4, GABRD, GABRG2, CLCN2, SLC4A3
5regulation of action potentialGO:00150810.3KCNMB3, CHRNA4
6synaptic transmissionGO:00726810.2HCN2, KCNJ9, KCNJ10, KCNMB3, CACNB4, SCN1B
7gamma-aminobutyric acid signaling pathwayGO:00721410.1GABRG2, CACNB4

Molecular functions related to Idiopathic Generalized Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1GABA-A receptor activityGO:00489010.4GABRG2, GABRD
2extracellular ligand-gated ion channel activityGO:00523010.0ZACN, GABRG2, GABRD

Products for genes affiliated with Idiopathic Generalized Epilepsy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Idiopathic Generalized Epilepsy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet