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MCID: IDP010

Idiopathic Generalized Epilepsy malady
2 drugs, 48 genes, 1 tissue, 415 related diseases, 11 phenotypes, 61 articles, clinical trials.

Summaries for Idiopathic Generalized Epilepsy

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6Disease Ontology, 44Wikipedia, 33OMIM, 22MalaCards
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Disease Ontology: An epilepsy that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.6

MalaCards: Idiopathic Generalized Epilepsy, also known as epilepsy, idiopathic generalized, is related to temporal lobe epilepsy and myoclonus. An important gene associated with Idiopathic Generalized Epilepsy is KCNJ10 (potassium inwardly-rectifying channel, subfamily J, member 10), and among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Antiarrhythmic Pathway, Pharmacodynamics. The drugs primidone and anti-epileptic agent [epc] and the compounds Halazepam and Fludiazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Wikipedia: Idiopathic generalized epilepsy (IGE) is a group of epileptic disorders that are believed to have a...44 more...

OMIM: 600669

Aliases & Descriptions for Idiopathic Generalized Epilepsy

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6Disease Ontology, 43UMLS, 33OMIM, 32Novoseek , 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

idiopathic generalized epilepsy 6 43
epilepsy, idiopathic generalized 33 32
epilepsy, generalized 43
generalised epilepsy 6
epilepsy 43

Related Diseases for Idiopathic Generalized Epilepsy

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13GeneCards, 14GeneDecks
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Disease types for idiopathic generalized epilepsy family:

epilepsy, idiopathic generalized, susceptibility to, 8 epilepsy, idiopathic generalized 11
epilepsy, idiopathic generalized 9 epilepsy, idiopathic generalized 6
epilepsy, idiopathic generalized 1 epilepsy, idiopathic generalized 4
epilepsy, idiopathic generalized 5 epilepsy, idiopathic generalized 3
epilepsy, idiopathic generalized 2 epilepsy, idiopathic generalized 7
epilepsy, idiopathic generalized, 10

Diseases related to idiopathic generalized epilepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 401)
idRelated DiseaseScoreTop Affiliating Genes
1temporal lobe epilepsy35.3SCN1B, GRIK2, SLC1A2, GABBR1, GAD2
2myoclonus34.3SCN2A, GABBR1, EFHC1, CSTB
3autosomal dominant nocturnal frontal lobe epilepsy33.2CHRNB2, CHRNA4
4generalized epilepsy with febrile seizures plus32.7GABRD, GABRG2, SCN1A, KCNQ2, SCN2A, SCN1B
5focal epilepsy32.4GABRD, GABRG2, SCN1A
6dravet syndrome31.8SCN1B, GABRG2, SCN1A, SCN2A
7juvenile myoclonic epilepsy31.7GABRD, CACNB4, CLCN2, GABRA1
8absence epilepsy31.6GABRB3, GABRA1, GABRG2, GABBR1, EFHC1, SLC1A2
9merrf syndrome31.2SCN1B, CSTB, SCN1A, CHRNA4, GABRG2
10benign epilepsy with centrotemporal spikes30.4SLC12A6, KCNQ3
11seizure disorder30.3SCN1A, SCN2A, KCNQ2
12severe myoclonic epilepsy of infancy (smei)30.3SCN1B, SCN1A, GABRG2, SCN2A
13epilepsy with generalized tonic-clonic seizures29.9SCN2A, SCN1A
14hemiplegic migraine29.2CACNA1A, ATP1A2, SCN1A
15childhood absence epilepsy29.2CLCN2, CHRNA4, CACNA1G, CACNA1H, GABBR1, GABRG2
16episodic ataxia29.1KCNQ3, CACNA1A, CACNB4, ATP1A2, SCN2A
17myokymia with neonatal epilepsy29.0KCNQ2, KCNQ3
18familial hemiplegic migraine28.9SCN1A, ATP1A2, CACNA1A
19epilepsies, partial28.7SCN1A, GABRG2, CHRNA4
20early myoclonic encephalopathy28.6SCN1A, CSTB
21epilepsy syndrome28.5KCNJ10, SCN1B, CLCN2, SCN1A, ALDH5A1, CHRNA4
22juvenile absence epilepsy28.3CACNA1A, ALDH5A1, GRIK2, CLCN2, CACNA1H, EFHC1
23febrile seizures28.3GABRG2, CHRNB2, CHRNA4, SCN1A, KCNQ3, SCN1B
24angelman syndrome28.1GAD2, GABRB3, GABRA1, GABRG2, CHRNA7
25intellectual disability27.8ALDH5A1, CHRNA7, GABRB3, PAX6, KCNQ2, GABRD
26status epilepticus27.4GABBR1, HCN2, HCN1, CACNA1A, ALDH5A1, SCN1A
27long qt syndrome26.8ZACN, KCNQ2, SCN1B, KCNQ3
28migraine with aura26.8CACNA1A, ATP1A2, SCN1A
29ataxia26.7GRIK2, ATP1A2, SCN2A, GABRD, KCNJ10, CSTB
30convulsions26.6GABBR1, SCN1A, CHRNA4, ATP1A2, CACNB4, CACNA1A
31blindness26.1HP, CLCN2, PAX6, SCN1A, ATP1A2, MAOA
32dementia26.0CHRNA4, SLC1A2, CSTB, CHRNA7, CHRNB2, MAOA
33febrile convulsions26.0KCNQ2, KCNQ3, HCN2, GABRG2, CACNB4, SCN1A
34cerebritis26.0SCN1B, CHRNA7, PAX6, CHRNB2, CHRNA4, ATP1A2
35benign neonatal seizures25.8KCNQ2, KCNQ3
36myokymia25.6CACNA1A, KCNQ3, KCNQ2
37neuropathy25.5KCNQ2, GABBR1, SLC12A6, CSTB, CACNA1A, ATP1A2
38mental retardation syndrome25.0PAX6, KCNQ2, MAOA, ATP1A2, ALDH5A1, CACNA1A
39diabetes mellitus25.0CACNA1A, GAD2, TAP1, HP, CACNA1G, ATP1A2
40benign familial neonatal-infantile seizures24.9KCNQ3, CHRNA4, KCNQ2, GABRG2, SCN1A, SCN1B
41headache24.8ATP1A2, CACNA1A, MAOA, SCN1A, HP
42down syndrome24.7CHRNA7, KCNQ2, GABRG2, ALDH5A1, CHRNA4, GABBR1
43neurologic diseases24.6CACNA1A, HP, ATP1A2, CACNB4, GAD2, SLC4A3
44mood disorder23.9GABRA1, SLC1A2, MAOA, GRIK2, GABRG2, GABBR1
45seizures23.0GABRB3, GAD2, GABRA1, GABRG2, HCN1, HCN2
46ischemia22.7PAX6, GABBR1, HP, CHRNA4, ATP1A2, GRIK2
47bipolar disorder22.3CHRNB2, CHRNA4, GAD2, GABRB3, GABRA1, GABRG2
48schizophrenia21.2CHRNB2, CHRNA7, KCNQ2, KCNJ10, KCNJ9, PAX6
49neuronitis20.3CSTB, GABRD, GABBR1, EFHC1, SLC1A2, SLC12A6
50episodic ataxia type 213.5CACNB4, CACNA1A

Graphical network of the top 20 diseases related to idiopathic generalized epilepsy:



Graphical network of diseases related to idiopathic generalized epilepsy

Clinical Features for Idiopathic Generalized Epilepsy

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33OMIM
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Clinical features from OMIM: 600669

Drugs & Therapeutics for Idiopathic Generalized Epilepsy

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for idiopathic generalized epilepsy

Drug clinical trials:

Search ClinicalTrials for idiopathic generalized epilepsy

Search NIH Clinical Center for idiopathic generalized epilepsy

Search CenterWatch for idiopathic generalized epilepsy

Inferred drug relations via UMLS/NDF-RT:

43 28 anti-epileptic agent [epc], primidone

Genetic Tests for Idiopathic Generalized Epilepsy

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Anatomical Context for Idiopathic Generalized Epilepsy

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22MalaCards
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MalaCards organs/tissues related to idiopathic generalized epilepsy:

22
Brain

Phenotypes for genes affiliated with Idiopathic Generalized Epilepsy

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25MGI
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MGI Mouse Phenotypes related to idiopathic generalized epilepsy:

25 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hearing/vestibular/ear phenotypeMP:00053779.3GABRB3, GABRA1, GABRD, SLC12A6, CACNB4, CHRNB2
2vision/eye phenotypeMP:00053919.0SLC4A3, CSTB, GLRA3, CACNB4, CHRNB2, SCN1B
3muscle phenotypeMP:00053698.4GAD2, EFHC1, SLC12A6, SLC4A3, CSTB, GLRB
4no phenotypic analysisMP:00030127.9GAD2, GABRB3, GABRA1, CSTB, HCN1, GLRA3
5integument phenotypeMP:00107717.9HCN2, TAP1, SLC4A3, SLC12A6, GABBR1, HCN1
6reproductive system phenotypeMP:00053897.6SLC12A6, GABBR1, GABRD, GABRG2, GABRA1, GABRB3
7homeostasis/metabolism phenotypeMP:00053766.5CACNA1A, GLRB, HP, SLC4A3, GABBR1, GABRG2
8growth/size phenotypeMP:00053786.0CACNA1H, GLRB, HCN2, CSTB, SLC12A6, SLC1A2
9mortality/agingMP:00107685.5GLRB, HP, HCN2, TAP1, SLC4A3, SLC1A2
10nervous system phenotypeMP:00036313.9CLCN2, CACNA1G, CACNB4, MAOA, GRM4, GRIK2
11behavior/neurological phenotypeMP:00053863.3GAD2, CACNB4, ALDH5A1, MAOA, GRM4, GRIK2

Publications for genes affiliated with Idiopathic Generalized Epilepsy

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35PubMed
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Articles related to idiopathic generalized epilepsy:

(show top 50)    (show all 61)
idTitleAuthorsYearAffiliating Genes
1Role of GRM4 in idiopathic generalized epilepsies ana lysed by genetic association and sequence analysis. (20338729)Muhle H.... Sander T.2010GRM4
2Dimorphism of TAP-1 gene in Caucasian with juvenile m yoclonic epilepsy and in Tunisian with idiopathic generalized epilepsies. (20141545)Layouni S.... Dogui M.2010TAP1
3CLCN2 variants in idiopathic generalized epilepsy. (19710712)Kleefuss-Lie A.... Lerche H.2009CLCN2
415q13.3 microdeletions increase risk of idiopathic generalized epilepsy. (19136953)Helbig I.... Sander T.2009CHRNA7
5Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. (19191339)Saint-Martin C.... Depienne C.2009CLCN2
6Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits. (17385675)Lee C.C.... Tsai F.J.2007CHRNA4, CHRNB2
7Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy. (17215107)Hempelmann A.... Sander T.2007GABRB3
8Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. (17696120)Heron S.E.... Zamponi G.W.2007CACNA1H
9Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. (16958040)Lorenz S.... Sander T.2007KCNMB3
10Lack of evidence for association between D2S124 and D2S111 polymorphisms of the SCN2A gene and idiopathic generalized epilepsy with generalized tonic clonic seizures. (17715289)Volzone A.... Curatolo P.2007SCN2A
11Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962. Online. (17397049)Singh B.... Yamakawa K.2007CACNA1G
12Association of GABRG2 polymorphisms with idiopathic generalized epilepsy. (17162195)Chou I.C.... Tsai F.J.2007GABRG2
13Idiopathic generalized epilepsy phenotypes associated with different EFHC1 mutations. (17159113)Stogmann E.... Zimprich A.2006EFHC1
14Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes. (16932951)Stogmann E.... Zimprich A.2006CLCN2
15A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. (16565161)Zhong X.... Agnew W.S.2006CACNA1H
16Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity. (16406321)Lorenz S.... Sander T.2006ALDH5A1
17Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. (16205844)Haider M.Z.... Al-Bloushi M.2005CHRNA4, CSTB, SCN1B
18Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy. (15929039)Tauer U.... Sander T.2005PPR1
19Genetics of idiopathic generalized epilepsies. (16302872)Gardiner M.2005ME2
20CLCN2 and idiopathic generalized epilepsy. (15508929)Heils A.2005CLCN2
21Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. (16190936)Lenzen K.P.... Sander T.2005ME2
22Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. (15532013)Greenberg D.A.... Kang H.2005ME2
23No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. (15911117)Lohoff F.W.... Buono R.J.2005ATP1A2, KCNJ10, KCNJ9
24SCN1A mutation analysis in myoclonic astatic epilepsy and severe idiopathic generalized epilepsy of infancy with generalized tonic- clonic seizures. (15944908)Ebach K.... Neubauer B.A.2005SCN1A
25Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy. (16023832)Lenzen K.P.... Sander T.2005GABRD
26Seizures of idiopathic generalized epilepsies. (16302874)Duron R.M.... Delgado-Escueta A.V.2005GABRG2, SCN1A, SCN1B
27Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. (15852375)Khosravani H.... Zamponi G.W.2005CACNA1H
28Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. (15725393)Lenzen K.P.... Sander T.2005KCNJ10
29Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. (15252188)Niemeyer M.I.... Cid L.P.2004CLCN2
30Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism. (15490286)Saccucci P.... Curatolo P.2004HP
31Genetic variation of CACNA1H in idiopathic generalized epilepsy. (15048902)Heron S.E.... Scheffer I.E.2004CACNA1H
32Exploring new gene discoveries in idiopathic generalized epilepsy. (12752457)Noebels J.L.2003ZACN
33Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. (12612585)Haug K.... Heils A.2003CLCN2
34Characterization of a 6p21 translocation breakpoint in a family with idiopathic generalized epilepsy. (14643000)Saez-Hernandez L.... Serratosa J.M.2003KCNK12
35Association of mu-opioid receptor subunit gene and idiopathic generalized epilepsy. (12221164)Wilkie H.... Makoff A.J.2002OPRM1
36Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy. (11342703)Chioza B.... Makoff A.J.2001CACNA1A
37Mutation analysis of the potassium chloride cotransporter KCC3 (SLC12A6) in rolandic and idiopathic generalized epilepsy. (11325574)Steinlein O.K.... Mount D.B.2001SLC12A6
38The voltage-gated sodium channel gene SCN2A and idiopathic generalized epilepsy. (11738931)Haug K.... Heils A.2001SCN2A
39Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (10970730)Haug K.... Heils A.2000ARC
40Coding and noncoding variation of the human calcium-channel beta4- subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. (10762541)Escayg A.... Meisler M.H.2000CACNB4
41Association analysis between a regulatory-promoter polymorphism of the human monoamine oxidase A gene and idiopathic generalized epilepsy. (10759301)Haug K.... Heils A.2000MAOA
42No evidence for association between the KCNQ3 gene and susceptibility to idiopathic generalized epilepsy. (10996506)Haug K.... Heils A.2000KCNQ3, KCNQ2
43Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy. (10463851)Sander T.... Janz D.1999PAX6
44Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. (10402495)Sander T.... Riess O.1999GABBR1
45The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. (10363917)Steinlein O.K.... Sander T.1999KCNQ2
46Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. (9933300)Peters H.C.... Riess O.1998GABBR1
47Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor alpha 1 and gamma 2 subunit gene cluster on chromosome 5. (8739126)Sander T.... Darlison M.G.1996GABRG2, GABRA1
48Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies. (7675232)Sander T.... Sailer U.1995GRIK2
49Mapping of genes predisposing to idiopathic generalized epilepsy. (8528209)Zara F.... Pandolfo M.1995EGI
50Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients. (1922810)Durner M.... Janz D.1991EGI

Expression for genes affiliated with Idiopathic Generalized Epilepsy

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Idiopathic Generalized Epilepsy

Pathways for genes affiliated with Idiopathic Generalized Epilepsy

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38Reactome, 34PharmGKB, 36QIAGEN, 10EMD Millipore, 41Thomson Reuters, 20KEGG
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Pathways related to idiopathic generalized epilepsy according to GeneDecks:

(show all 39)
idPathwayScoreTop Affiliating Genes
1Postsynaptic nicotinic acetylcholine receptors3810.3CHRNA4, CHRNB2
2Antiarrhythmic Pathway, Pharmacodynamics3410.2HCN2, CACNA1H, CACNA1G, SCN1B
3nNOS Signaling in Skeletal Muscle3610.2CACNA1H, CACNA1A, CACNA1G, CACNB4
4DREAM Repression and Dynorphin Expression3610.2CACNA1H, CACNA1A, CACNA1G, CACNB4
5Hepatic ABC Transporters3610.2SLC4A3, ATP1A2, KCNK12, CLCN2
6Fc-Gamma-RIIB Signaling in B-Cells3610.2CACNA1H, CACNA1A, CACNA1G, CACNB4
7Fc-GammaR Pathway3610.1CACNB4, CACNA1G, CACNA1A, CACNA1H
8CCR5 Pathway in Macrophages3610.1CACNA1H, CACNA1A, CACNA1G, CACNB4
9G-Beta Gamma Signaling3610.1CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNJ9
10BMP Pathway3610.1CACNA1H, CACNA1A, CACNA1G, CACNB4
11Sweet Taste Signaling3610.1CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNK12
12Potassium transporters- inward current1010.1HCN2, HCN1, KCNJ10, KCNJ9
13Caspase Cascade3610.1CACNA1H, CACNA1A, CACNA1G, CACNB4
14Melatonin Signaling3610.0CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNK12
15Transcription CREB pathway1010.0CACNB4, CACNA1G, CACNA1A, CACNA1H
16GHRH Signaling369.9CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
17Fc-EpsilonRI Pathway369.9CACNA1H, CACNA1A, CACNA1G, CACNB4
18Cellular Effects of Sildenafil369.9KCNK12, CACNB4, CACNA1G, CACNA1A, CACNA1H
19Sodium channels and transporters- inward current109.9HCN2, HCN1, SCN1A, SCN2A
20PDGF Pathway369.9CACNA1H, CACNA1A, CACNA1G, CACNB4
21Calpain Protease Regulates Cellular Mechanics369.9CACNB4, CACNA1G, CACNA1A, CACNA1H
22GABA signaling in brain109.8GAD2, GABRB3, GABRA1, GABRG2, GABRD, GABBR1
23Androgen Signaling369.8CACNA1H, CACNA1A, CACNA1G, CACNB4
24PKA Signaling369.7CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
25Axon guidance389.7CACNA1H, CACNA1G, CACNB4, SCN1B, KCNQ3, KCNQ2
26Calcium channels109.7CACNA1H, CACNA1A, CACNA1G, CHRNA4, CHRNB2, CHRNA7
27Activation of cAMP-Dependent PKA369.7CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
28Dopamine-DARPP32 Feedback onto cAMP Pathway369.6CACNA1A, CACNB4, KCNQ3, KCNQ2, KCNJ10, KCNJ9
29cAMP Pathway369.6CACNA1H, CACNA1A, CACNA1G, CACNB4, SCN1A, SCN1B
30Celecoxib Pathway, Pharmacodynamics349.6CACNA1H, CACNA1A, CACNA1G, CACNB4, KCNQ3, KCNQ2
31Transcription_CREB pathway419.6CACNA1H, CACNA1A, CACNA1G, CACNB4
32Neuronal System389.5GABRB3, GABRA1, GABRG2, HCN2, HCN1, ALDH5A1
33Glutamic acid signaling109.4GAD2, SLC1A2, GRM4, GRIK2
34Cholinergic synapse209.3CACNA1A, CHRNA4, CHRNB2, CHRNA7, KCNQ3, KCNQ2
35Sperm Motility369.2GABRB3, GABRA1, GABRG2, GABRD, HCN2, HCN1
36Synaptic transmission- ion currents109.2KCNJ9, CACNA1H, CACNA1A, CACNA1G, SCN1A, SCN2A
37CREB Pathway369.1CACNA1H, CACNA1A, CACNA1G, CACNB4, GRM4, GRIK2
38Intracellular Calcium Signaling369.0CACNA1H, CACNA1A, CACNA1G, CACNB4, GRIK2, CHRNA4
39Neuroactive ligand-receptor interaction208.0GABRB3, GABRA1, GABRG2, GABRD, GABBR1, GLRB

Compounds for genes affiliated with Idiopathic Generalized Epilepsy

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9DrugBank, 42Tocris Bioscience, 32Novoseek , 34PharmGKB, 18HMDB
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Compounds related to idiopathic generalized epilepsy according to GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1Halazepam9 9 11.2GABRB3, GABRA1, GABRG2, GABRD
2Fludiazepam9 9 11.2GABRD, GABRG2, GABRA1, GABRB3
3Cinolazepam9 9 11.2GABRD, GABRG2, GABRA1, GABRB3
4(+)-bicuculline42 10.2GABRD, GABRG2, GABRA1, GABRB3
5sr 95531 hydrobromide42 10.2GABRD, GABRG2, GABRA1, GABRB3
6Prazepam9 9 11.2GABRB3, GABRA1, GABRG2, GABRD
7Adinazolam9 9 11.2GABRB3, GABRA1, GABRG2, GABRD
8estazolam32 9 9 12.2GABRB3, GABRA1, GABRG2, GABRD
9quazepam32 9 9 12.1GABRB3, GABRA1, GABRG2, GABRD
10muscimol32 42 11.1GABRB3, GABRA1, GABRG2, GABRD, GABBR1
11Clotiazepam9 9 11.1GABRB3, GABRA1, GABRG2, GABRD
12Clorazepate9 9 11.1GABRB3, GABRA1, GABRG2, GABRD
13nitrazepam32 9 9 12.1SCN1A, GABRD, GABRG2, GABRA1, GABRB3
14Oxazepam9 9 11.1GABRB3, GABRA1, GABRG2, GABRD
15diazepam32 34 9 9 13.0GABRB3, GABRA1, GABRG2, GABRD, GABBR1
16flurazepam32 9 9 12.0GABRB3, GABRA1, GABRG2, GABRD
17clobazam34 32 9 9 13.0GABRB3, GABRA1, GABRG2, GABRD
18Temazepam9 9 10.9GABRB3, GABRA1, GABRG2, GABRD
19bromazepam32 9 9 11.9GABRB3, GABRA1, GABRG2, GABRD, MAOA
20lorazepam32 34 9 9 12.9GABRB3, GABRA1, GABRG2, GABRD
21triazolam32 9 9 11.9GABRD, GABRG2, GABRA1, GABRB3
22alprazolam32 9 9 11.8GABRB3, GABRA1, GABRG2, GABRD, MAOA
23chlordiazepoxide32 9 9 11.8GABRB3, GABRA1, GABRG2, GABRD
24clonazepam32 9 9 11.7GABRB3, GABRA1, GABRG2, GABRD, GABBR1, MAOA
25zonisamide32 9 9 11.7CACNA1H, CACNA1G, MAOA, SCN1A, SCN2A, SCN1B
26Heptabarbital9 9 10.6CHRNA4, CHRNA7, GRIK2, GABRA1
27Butalbital9 9 10.6GABRA1, GRIK2, CHRNA4, CHRNA7
28Barbituric acid derivative9 9 10.6GABRA1, GRIK2, CHRNA4, CHRNA7
29Metharbital9 9 10.6CHRNA7, CHRNA4, GRIK2, GABRA1
30Talbutal9 9 10.6CHRNA7, CHRNA4, GRIK2, GABRA1
31Aprobarbital9 9 10.6CHRNA7, CHRNA4, GRIK2, GABRA1
32Barbital9 9 10.6CHRNA7, CHRNA4, GRIK2, GABRA1
33Butabarbital9 9 10.6CHRNA7, CHRNA4, GABRA1, GRIK2
34Butethal9 9 10.6GABRA1, GRIK2, CHRNA4, CHRNA7
35Methylphenobarbital9 9 10.6GABRA1, GRIK2, CHRNA4, CHRNA7
36amobarbital32 9 9 11.6GABRA1, GRIK2, CHRNA4, CHRNA7
37Secobarbital9 9 10.6GABRA1, GRIK2, CHRNA4, CHRNA7
38primidone32 9 9 11.5GABRA1, GRIK2, CHRNA4, CHRNA7
39pentobarbital32 9 9 11.5GABRA1, GABBR1, GRIK2, CHRNA4, CHRNA7
40hexobarbital32 9 9 11.5GABRA1, GRIK2, CHRNA4, CHRNA7
41thiopental32 9 9 11.4GABRA1, GRIK2, CHRNA4, CHRNA7
42chlorine32 18 10.3GABRB3, GABRA1, GABRG2, GABRD, SLC12A6, HCN2
434-aminopyridine32 42 10.0GABBR1, CACNA1A, KCNQ3, KCNQ2, KCNMB3
44acetylcholine32 9 18 9 11.7GAD2, GABBR1, CACNA1A, CHRNA4, CHRNB2, CHRNA7
45potassium32 9 18 9 11.4ZACN, ATP1A2, CACNA1A, HCN2, GABBR1, GABRG2
46nmda32 42 9.2GAD2, GABBR1, SLC1A2, GLRB, MAOA, GRM4
47gaba32 42 8.7GAD2, GABRB3, GABRA1, GABRG2, GABBR1, SLC1A2
48sodium32 18 8.5CLCN2, GABRG2, SLC1A2, HCN2, HCN1, HP
49glutamate32 7.1GAD2, GABBR1, SLC1A2, TAP1, HP, CACNA1A
50calcium32 9 18 9 10.0GAD2, GABBR1, EFHC1, SLC1A2, OPRM1, CACNA1H

GO Terms for genes affiliated with Idiopathic Generalized Epilepsy

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Sources:
12Gene Ontology
See all sources

Cellular components related to idiopathic generalized epilepsy according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated calcium channel complexGO:0058919.9CACNB4, CACNA1G, CACNA1A, CACNA1H
2voltage-gated sodium channel complexGO:0015189.9SCN1B, SCN2A, SCN1A
3node of RanvierGO:0332689.6SCN2A, KCNQ3, KCNQ2
4voltage-gated potassium channel complexGO:0080769.5KCNMB3, KCNQ2, KCNQ3, HCN2
5acetylcholine-gated channel complexGO:0058929.5CHRNA4, CHRNB2, CHRNA7
6chloride channel complexGO:0347079.4GABRB3, GABRA1, GABRG2, GABRD, GLRB, GLRA3
7postsynaptic membraneGO:0452117.9CHRNA7, GABRB3, GABRA1, GABRG2, GABRD, GABBR1
8cell junctionGO:0300547.7GABRD, GABRG2, GABRA1, GABRB3, GAD2, GABBR1
9integral to plasma membraneGO:0058877.4SLC4A3, GABBR1, GABRD, GABRG2, GABRA1, GABRB3
10plasma membraneGO:0058864.2OPRM1, HCN2, HCN1, GLRB, GLRA3, SLC4A3

Biological processes related to idiopathic generalized epilepsy according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, GABAergicGO:05193210.1GABRA1, GABRG2
2adult walking behaviorGO:00762810.1GLRB, CACNA1A, CACNB4, KCNJ10
3membrane depolarizationGO:05189910.0CACNA1A, CACNB4, CHRNA4, CHRNB2, SCN1B
4gamma-aminobutyric acid signaling pathwayGO:00721410.0GABRA1, GABRG2, GABBR1, CACNA1A, CACNB4
5regulation of membrane potentialGO:0423919.9HCN2, GLRB, CACNA1H, CACNA1G, CHRNA4
6learningGO:0076129.9CHRNB2, ARC, GRM4
7response to nicotineGO:0350949.9GABBR1, CHRNA4, CHRNB2, CHRNA7
8cognitionGO:0508909.9CHRNA4, CHRNB2, CHRNA7
9gamma-aminobutyric acid secretionGO:0140519.9CACNA1A, CACNB4
10synaptic transmission, glutamatergicGO:0352499.5GRIK2, CACNB4, CACNA1A
11ion transmembrane transportGO:0342209.5GABRB3, GABRA1, GABRG2, GLRB, GLRA3, ATP1A2
12neurotransmitter secretionGO:0072699.4GRM4, MAOA, ALDH5A1, GAD2
13ion transportGO:0068119.3SLC1A2, SLC12A6, SLC4A3, GLRB, CHRNA4, CHRNB2
14axon guidanceGO:0074119.3CACNA1H, CACNA1G, CACNB4, SCN1B, KCNQ3, KCNQ2
15potassium ion transportGO:0068139.0SLC12A6, HCN1, ATP1A2, KCNQ3, KCNQ2, KCNMB3
16transportGO:0068109.0GABRB3, GABRA1, GABRG2, GABRD, SLC4A3, CACNA1H
17transmembrane transportGO:0550858.9GABRB3, GABRA1, GABRG2, SLC1A2, SLC12A6, SLC4A3
18synaptic transmissionGO:0072684.6KCNJ9, CACNA1A, GLRA3, GLRB, HCN1, HCN2

Molecular functions related to idiopathic generalized epilepsy according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1GABA-A receptor activityGO:00489010.1GABRB3, GABRA1, GABRG2, GABRD
2extracellular-glycine-gated chloride channel activityGO:01693410.0GLRA3, GLRB
3acetylcholine receptor activityGO:0154649.9CHRNA7, CHRNB2, CHRNA4
4acetylcholine bindingGO:0421669.9CHRNA7, CHRNB2, CHRNA4
5low voltage-gated calcium channel activityGO:0083329.9CACNA1G, CACNA1H
6acetylcholine-activated cation-selective channel activityGO:0048899.8CHRNA4, CHRNB2, CHRNA7
7chloride channel activityGO:0052549.8GABRD, GABRG2, GABRA1, GABRB3
8extracellular ligand-gated ion channel activityGO:0052309.7ZACN, GLRA3, GABRD, GABRG2, GABRA1, GABRB3
9potassium channel activityGO:0052679.4KCNK12, KCNQ2, KCNQ3, HCN1
10voltage-gated potassium channel activityGO:0052499.3HCN2, HCN1, KCNQ3, KCNQ2

Sources for Idiopathic Generalized Epilepsy

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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