MCID: IDP011
MIFTS: 53

Idiopathic Interstitial Pneumonia malady

Summaries for Idiopathic Interstitial Pneumonia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

MalaCards: Idiopathic Interstitial Pneumonia, also known as diffuse idiopathic pulmonary fibrosis, is related to pneumonia and respiratory failure. An important gene associated with Idiopathic Interstitial Pneumonia is CMA1 (chymase 1, mast cell), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Degradation of the extracellular matrix. The compounds endotoxin and rantes have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause, lung and testes, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Disease Ontology:8 A pneumonia located in the lung parenchyma of unknown cause.

Aliases & Classifications for Idiopathic Interstitial Pneumonia

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8Disease Ontology, 56SNOMED-CT, 27ICD9CM, 60UMLS, 34MeSH
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Aliases & Descriptions:

idiopathic interstitial pneumonia 8
diffuse idiopathic pulmonary fibrosis 8
idiopathic fibrosing alveolitis 8


Related Diseases for Idiopathic Interstitial Pneumonia

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17GeneCards, 18GeneDecks
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Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7ELANE, IL13, SCGB1A1, SFTPD, SFTPC, CCL18
2respiratory failure30.4SCGB1A1, SFTPD, SFTPC
3interstitial lung disease30.4SFTPC, SFTPD, IL13RA2
4connective tissue disease30.4TLR9, THBD
5collagen disease30.4SFTPD, THBD
6vascular disease30.4ELANE, THBD, THBS1
7lung cancer30.4ASCL1, KRT14, THBS1, IL4R, SCGB1A1, SFTPC
8arthritis30.2THBS1, IL13, CCR7
9dermatomyositis30.2CCR7, SFTPD, THBS1
10sarcoidosis30.2CCL18, SFTPD, SCGB1A1, IL13, TGIF1
11idiopathic pulmonary fibrosis30.1CCR7, SFTPC, SFTPD, SCGB1A1, IL13, ELANE
12nonspecific interstitial pneumonia10.6
13acute interstitial pneumonia10.6
14desquamative interstitial pneumonia10.4
15pulmonary systemic sclerosis10.1
16lymphoid interstitial pneumonia10.1
17cryptogenic organizing pneumonia10.1
18respiratory bronchiolitis-associated interstitial lung disease10.1
19psoriatic arthritis10.1
20viral pneumonia10.1
21bird fancier's lung10.1
22myopathy10.1
23airway-centered interstitial fibrosis10.1
24esophagitis10.0IL13
25peritonitis10.0CMA1
26nephritis10.0SCGB1A1
27bronchiolitis obliterans10.0SCGB1A1
28myocardial infarction10.0POSTN
29pancreatitis10.0ELANE
30thromboembolism10.0THBD
31hepatitis c10.0TGIF1
32sarcoma10.0IL4R
33gingivitis10.0ELANE
34bronchiolitis10.0IL13, IL4R
35proteinuria10.0SCGB1A1
36malaria10.0TLR9, TGIF1
37rhinitis10.0SCGB1A1, IL13, CMA1
38lupus erythematosus10.0TLR9, THBD
39pheochromocytoma10.0NTF3, ASCL1
40cervical cancer10.0THBS1, KRT14
41bronchopulmonary dysplasia10.0ELANE, SCGB1A1
42diabetic retinopathy10.0THBS1
43mastocytosis10.0IL13, CMA1
44lupus nephritis10.0THBD, TLR9
45medulloblastoma10.0NTF3, IL4R, IL13RA2
46asthma10.0SCGB1A1, IL13
47gastritis10.0SFTPD, TLR9
48large cell carcinoma10.0THBD, SFTPD, SFTPC
49coronary heart disease10.0THBD, THBS1
50meningioma10.0TGIF1

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to idiopathic interstitial pneumonia

Clinical Features for Idiopathic Interstitial Pneumonia

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Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Idiopathic Interstitial Pneumonia

Drug clinical trials:

Search ClinicalTrials for Idiopathic Interstitial Pneumonia

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Search CenterWatch for Idiopathic Interstitial Pneumonia

Genetic Tests for Idiopathic Interstitial Pneumonia

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Anatomical Context for Idiopathic Interstitial Pneumonia

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Idiopathic Interstitial Pneumonia:

32
Lung, Testes, Bone, Bone marrow, Colon

FMA organs/tissues related to Idiopathic Interstitial Pneumonia:

14
The lung parenchyma of unknown cause

Animal Models for Idiopathic Interstitial Pneumonia or affiliated genes

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36MGI
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Publications for Idiopathic Interstitial Pneumonia

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50PubMed
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Articles related to Idiopathic Interstitial Pneumonia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. (23678265)
2013
2
The histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man. (23664319)
2013
3
Physical activity in daily life of patients with fibrotic idiopathic interstitial pneumonia. (23928896)
2013
4
Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis/usual interstitial pneumonia. (22882269)
2012
5
High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. (23364926)
2012
6
Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders? (21273390)
2011
7
Prognostic value of immunohistochemical surfactant protein A expression in regenerative/hyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias. (21435274)
2011
8
Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. (21177844)
2011
9
Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization. (20382190)
2010
10
Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia. (20542676)
2010
11
Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD). (20483576)
2010
12
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. (19690403)
2010
13
Venous thromboembolism and risk of idiopathic interstitial pneumonia: a nationwide study. (20167844)
2010
14
Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis. (19954818)
2010
15
Semiquantitative analysis of surgical biopsies of distinct lung lobes of patients with usual interstitial pneumonia/idiopathic pulmonary fibrosis. (19669006)
2009
16
Pathologic and radiologic differences between idiopathic and collagen vascular disease-related usual interstitial pneumonia. (19255290)
2009
17
Idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia should stay separate. (18448513)
2008
18
Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia. (18073456)
2008
19
Comparison of clinicoradiologic manifestation of nonspecific interstitial pneumonia and usual interstitial pneumonia/idiopathic pulmonary fibrosis: a report from NRITLD. (19561896)
2008
20
Single gene expression as a prognostic marker in idiopathic interstitial pneumonia? (18824885)
2008
21
Assessment of gene transcription demonstrates connection with the clinical course of idiopathic interstitial pneumonia. (18525195)
2008
22
High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis. (18983650)
2008
23
The role of lung biopsy in the diagnosis and management of idiopathic interstitial pneumonia. (23485138)
2008
24
Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. (18069415)
2007
25
Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: clinical significance of remodeling process. (17294340)
2007
26
CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. (17469163)
2007
27
High-resolution chest tomography in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: utility and challenges. (17940493)
2007
28
Acute interstitial pneumonia and acute exacerbations of idiopathic pulmonary fibrosis. (17195142)
2006
29
Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia. (16493155)
2006
30
Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia. (16082627)
2005
31
Nonspecific interstitial pneumonia: a provisional category of idiopathic interstitial pneumonia. (15316445)
2004
32
Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis? (15256390)
2004
33
A case with acute quadriplegic myopathy following intensive care for idiopathic interstitial pneumonia. (15055401)
2003
34
Idiopathic interstitial pneumonia following stem cell transplantation. (12868990)
2003
35
Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. (12791580)
2003
36
Octreoscan perspectives in sarcoidosis and idiopathic interstitial pneumonia. (15068232)
2003
37
Steroid treatment based on the findings of transbronchial biopsy in idiopathic interstitial pneumonia. (12449176)
2002
38
Clinical significance of histological classification of idiopathic interstitial pneumonia. (11866008)
2002
39
Intercellular adhesion molecule-1 in patients with idiopathic interstitial pneumonia. (11512562)
2001
40
Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia. (10632484)
2000
41
Diagnostic accuracy of thin-section CT in idiopathic interstitial pneumonia. (10831723)
2000
42
Myofibroblasts and S-100 protein positive cells in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial pneumonia. (10543278)
1999
43
Classification and recent advances in idiopathic interstitial pneumonia. (10813199)
1998
44
Surfactant protein A in bronchoalveolar lavage fluid from patients with idiopathic interstitial pneumonia]. (9022314)
1996
45
Role of alveolar macrophages in the pathogenesis of idiopathic interstitial pneumonia]. (9216211)
1996
46
Factors affecting prognosis of idiopathic interstitial pneumonia. (8701780)
1996
47
Three cases of idiopathic interstitial pneumonia with bullae seen in schoolteachers. (7485195)
1995
48
Lymphoid interstitial pneumonia as a pulmonary lesion of idiopathic plasmacytic lymphadenopathy with hyperimmunoglobulinemia. (8069020)
1994
49
Four cases of lung cancer associated with idiopathic interstitial pneumonia. (2167507)
1990
50
Idiopathic interstitial pneumonia following bone marrow transplantation: the relationship with total body irradiation. (7033190)
1981

Genetic Variations for Idiopathic Interstitial Pneumonia

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Expression for genes affiliated with Idiopathic Interstitial Pneumonia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for genes affiliated with Idiopathic Interstitial Pneumonia

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52R&D Systems, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL4R, IL13
2
Hide members
10.2ELANE, CMA1
310.0ELANE, SCGB1A1, SFTPD
4
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10.0IL4R, TLR9, CCR7
59.9IL13RA1, IL4R, IL13RA2
69.8IL13, IL13RA1, IL4R, IL13RA2
7
Hide members
9.7CCR7, CCL18, IL13, IL4R, IL13RA2
8
Hide members
9.4CCL18, NTF3, IL13, IL13RA1, IL4R, IL13RA2
9
Hide members
9.3CCR7, CCL18, NTF3, IL13, IL13RA1, IL4R
10
Hide members
9.3CCR7, CCL18, NTF3, IL13, IL13RA1, IL4R
11
Hide members
9.1IL13RA2, CCR7, CCL18, TLR9, NTF3, IL13

Compounds for genes affiliated with Idiopathic Interstitial Pneumonia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.6SCGB1A1, THBD
2rantes4410.6CCR7, IL4R
3sivelestat sodium hydrate4410.5ELANE, SFTPD
4curosurf4410.5SFTPC, ELANE
5sivelestat4410.5ELANE, SFTPD
6glutamate4410.4THBD
7survanta4410.4ELANE, SFTPC
8vitamin a44 11 2412.4KRT14, ELANE
9indoleamine4410.4TLR9, IL13, THBS1
10allergens4410.3CMA1, IL4R, IL13, SFTPD
11kininogen4410.3THBS1
12serine4410.3KRT14, THBS1, CMA1, IL13
13ovomucoid4410.3ELANE
14bromodeoxyuridine4410.3SCGB1A1, NTF3, IL13, KRT14
15ccl344 2811.3IL13, TLR9, CCL18, CCR7
16tarc4410.3CCR7, CCL18, IL13, IL4R
17oxygen44 2411.3SFTPC, SFTPD, SCGB1A1, ELANE
18exotoxin-a4410.2ELANE, IL4R, IL13RA1, IL13
19pentoxifylline44 1111.2ELANE, THBD, IL13
20heparin44 28 11 2413.2NTF3, IL13, CMA1, ELANE, TGIF1
21n-formylmethionyl-leucylphenylalanine4410.2ELANE, THBD, THBS1
22ccl444 2811.1CCR7, CCL18, IL13
23calcitriol44 59 11 2413.1IL13, THBS1, THBD, TGIF1
24hyaluronic acid44 2411.1SCGB1A1, IL13, THBS1, THBD, ELANE
25actinomycin d4410.1THBD, IL4R, IL13, NTF3, SFTPC
26histamine44 28 2412.0SFTPD, NTF3, IL13, IL4R, CMA1, THBD
27paraffin4410.0KRT14, THBD, THBS1, CMA1, NTF3
28paricalcitol44 1111.0THBS1, THBD
29doxycycline44 1111.0TGIF1, SFTPC, SCGB1A1, IL13, THBS1, ELANE
30lactate4410.0TGIF1, ELANE, THBD, IL13, SFTPD
31vitamin d4410.0TGIF1, ELANE, KRT14, THBD, THBS1
32cyclosporin a44 28 5911.9IL13, IL4R, THBS1, THBD, ELANE
33chloramphenicol44 2 1111.9SFTPC, SCGB1A1, NTF3, IL13, THBD, KRT14
34progesterone44 59 28 11 2413.9SCGB1A1, NTF3, THBS1, THBD, KRT14, TGIF1
35phosphatidylinositol449.9CCR7, SFTPD, SCGB1A1, NTF3, IL13, IL4R
36matrigel449.8THBD, THBS1, NTF3, CCR7
37steroid449.8SFTPD, SCGB1A1, NTF3, IL13, IL4R, THBD
38cholesterol44 28 11 2412.8SFTPC, SFTPD, CMA1, THBS1, THBD, KRT14
39threonine449.8SFTPC, NTF3, IL13, THBS1, KRT14, TGIF1
40thymidine44 2410.8SFTPD, NTF3, IL13, IL13RA1, IL4R, THBS1
41alanine449.7CCR7, CCL18, SCGB1A1, IL13, THBS1, THBD
42lipid449.6CCR7, SFTPC, SFTPD, SCGB1A1, THBS1, THBD
43ribonucleic acid449.5TGIF1, THBS1, NTF3, SFTPC
44retinoic acid44 2410.5SFTPC, NTF3, IL13, THBS1, THBD, KRT14
45nitric oxide44 11 2411.5TLR9, SFTPD, SCGB1A1, NTF3, IL13, IL13RA1
46dexamethasone44 49 28 1112.5CCL18, SFTPC, SFTPD, GREM1, IL13, IL4R
47vegf449.4CCL18, SFTPC, NTF3, POSTN, IL13, IL13RA1
48cysteine449.3SFTPC, SFTPD, GREM1, NTF3, IL13, CMA1
49calcium44 49 11 2412.1SCGB1A1, SFTPD, SFTPC, CCL18, CCR7, NTF3
50tyrosine449.0CCR7, TLR9, GREM1, NTF3, IL13, IL13RA1

GO Terms for genes affiliated with Idiopathic Interstitial Pneumonia

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16Gene Ontology
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Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.7ELANE, THBS1, SCGB1A1
2extracellular regionGO:0055769.4TLR9, SFTPD, NTF3, IL13, CMA1, THBS1
3extracellular spaceGO:0056158.9IL4R, GREM1, IL13RA2, THBS1, SCGB1A1, SFTPD

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.2THBD, THBS1
2positive regulation of macrophage activationGO:04303210.2IL13, IL4R, THBS1
3positive regulation of receptor internalizationGO:00209210.2NTF3, GREM1
4positive regulation of angiogenesisGO:04576610.0THBS1, CMA1, GREM1
5response to lipopolysaccharideGO:03249610.0ELANE, IL13, SCGB1A1, SFTPC, CCR7
6cell-cell signalingGO:00726710.0CCL18, GREM1, NTF3, IL13
7immune responseGO:0069559.8CCR7, CCL18, IL13, IL4R, THBS1
8extracellular matrix organizationGO:0301989.7POSTN, CMA1, THBS1, ELANE
9inflammatory responseGO:0069549.6IL13, TLR9, CCL18, CCR7
10signal transductionGO:0071659.6CCL18, SCGB1A1, NTF3, IL13, IL4R, IL13RA2

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.2TGIF1, SFTPC, SFTPD, SCGB1A1, GREM1, IL13

Products for genes affiliated with Idiopathic Interstitial Pneumonia

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Idiopathic Interstitial Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet