IPF
MCID: IDP011
MIFTS: 56

Idiopathic Interstitial Pneumonia (IPF) malady

Categories: Respiratory diseases

Aliases & Classifications for Idiopathic Interstitial Pneumonia

Aliases & Descriptions for Idiopathic Interstitial Pneumonia:

Name: Idiopathic Interstitial Pneumonia 12 14
Pulmonary Fibrosis 42 69
Idiopathic Interstitial Pneumonia, Not Otherwise Specified 69
Diffuse Idiopathic Pulmonary Fibrosis 12
Idiopathic Interstitial Pneumonias 69
Idiopathic Fibrosing Alveolitis 12
Hamman-Rich Syndrome 69
Ipf 12

Classifications:



Summaries for Idiopathic Interstitial Pneumonia

Disease Ontology : 12 A pneumonia located in the lung parenchyma of unknown cause.

MalaCards based summary : Idiopathic Interstitial Pneumonia, also known as pulmonary fibrosis, is related to nonspecific interstitial pneumonia and airway-centered interstitial fibrosis, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Idiopathic Interstitial Pneumonia is MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Bosentan and Nintedanib have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 71 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

Related Diseases for Idiopathic Interstitial Pneumonia

Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
id Related Disease Score Top Affiliating Genes
1 nonspecific interstitial pneumonia 32.8 ICAM1 IFNG IL4
2 airway-centered interstitial fibrosis 11.1
3 cryptogenic organizing pneumonia 11.0
4 respiratory bronchiolitis-interstitial lung disease syndrome 11.0
5 acute interstitial pneumonia 11.0
6 pulmonary fibrosis, idiopathic 11.0
7 lymphoid interstitial pneumonia 11.0
8 interstitial pneumonitis, desquamative, familial 11.0
9 pneumonia 10.7
10 myoglobinuria recurrent 10.3 IFNG IL4
11 ectodermal dysplasia with natal teeth, turnpenny type 10.3 SFTPA1 SFTPC
12 spastic diplegia 10.3 IFNG IL13 TGFB1
13 crustacean allergy 10.3 IFNG IL13 IL4
14 common wart 10.3 SFTPA1 SFTPC SFTPD
15 acute gonococcal prostatitis 10.3 IFNG IL13 IL4
16 cranial nerve malignant neoplasm 10.3 SFTPA1 SFTPA2 SFTPD
17 plantar wart 10.3 CXCL8 IFNG TGFB1
18 dissociated nystagmus 10.3 IL4 SFTPA2 SFTPD
19 urethral intrinsic sphincter deficiency 10.3 CCL2 IFNG IL4
20 lymphangiectasia, intestinal 10.2 CTGF IL4 TGFB1
21 immune-complex glomerulonephritis 10.2 CCL2 IFNG IL4
22 neurotrophic keratoconjunctivitis 10.2 CCL2 SFTPC SFTPD
23 paratyphoid fever 10.2 IFNG IL13 IL4
24 scn9a-related inherited erythromelalgia 10.2 MUC5B SFTPA1 SFTPA2 SFTPC
25 erythematosquamous dermatosis 10.2 IFNG IL13 IL4 TGFB1
26 uterine inflammatory disease 10.2 EDN1 SERPINE1
27 ectothrix infectious disease 10.2 CXCL8 IFNG SFTPD
28 proximal symphalangism 10.2 CCL2 IFNG IL4
29 dengue hemorrhagic fever 10.2 IFNG IL13 IL4
30 nasopharyngitis 10.2 CXCL8 IFNG IL4
31 hypertrichosis of eyelid 10.2 CCL2 CTGF TGFB1
32 glucose intolerance 10.2 CCL2 CXCL8 IFNG
33 esophagus lymphoma 10.2 CXCL8 EDN1 IFNG
34 ectodermal dysplasia bartalos type 10.2 IFNG IL4 VEGFA
35 burns 10.2 CXCL8 IFNG TGFB1
36 renal tubular dysgenesis, agt-related 10.2 SFTPA1 SFTPA2 SFTPC SFTPD
37 neuroectodermal endocrine syndrome 10.2 CTGF EDN1 TGFB1
38 albinism, oculocutaneous, type ia 10.2 CCL2 CTGF TGFB1
39 upper respiratory tract disease 10.2 CTGF TGFB1 VEGFA
40 status epilepticus 10.2 CCL2 IFNG IL4
41 mixed mineral dust pneumoconiosis 10.2 CCL2 CXCL8 IFNG
42 myiasis 10.2 CXCL8 IFNG IL4 TGFB1
43 liver inflammatory pseudotumor 10.2 IFNG IL4 TGFB1
44 visceral steatosis 10.2 ICAM1 IL13 IL4
45 hyperimmunoglobulin syndrome 10.2 CCL2 CXCL8 IFNG
46 acute necrotizing encephalitis 10.2 CCL2 CTGF TGFB1
47 cholera 10.2 CTGF ELANE TGFB1
48 immunodeficiency due to a late component of complement deficiency 10.2 CXCL8 IFNG VEGFA
49 baritosis 10.2 CCL2 CXCL8 MUC5B TGFB1
50 breast apocrine carcinoma in situ 10.2 CCL2 CXCL8 SFTPD

Comorbidity relations with Idiopathic Interstitial Pneumonia via Phenotypic Disease Network (PDN): (show all 22)


Acute Cystitis Bronchiectasis
Bronchitis Bronchopneumonia
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypothyroidism Intermediate Coronary Syndrome
Ischemic Heart Disease Left Ventricular Outflow Tract Obstruction
Mitral Valve Disease Osteoporosis
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Pulmonary Hypertension, Familial Primary, 1, with or Without Hht Respiratory Failure
Rheumatoid Arthritis Rheumatoid Lung Disease

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to Idiopathic Interstitial Pneumonia

Symptoms & Phenotypes for Idiopathic Interstitial Pneumonia

UMLS symptoms related to Idiopathic Interstitial Pneumonia:


coughing, hemoptysis, snoring

MGI Mouse Phenotypes related to Idiopathic Interstitial Pneumonia:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 SFTPA1 SFTPD TGFB1 VEGFA CD34 CTGF
2 growth/size/body region MP:0005378 10.32 CTGF EDN1 GREM1 ICAM1 IFNG IL13
3 immune system MP:0005387 10.28 CCL2 CD34 ELANE ICAM1 IFNG IL13
4 hematopoietic system MP:0005397 10.27 CD34 ELANE ICAM1 IFNG IL13 IL4
5 cellular MP:0005384 10.25 CD34 CTGF GREM1 ICAM1 IFNG IL13
6 mortality/aging MP:0010768 10.22 SFTPC SFTPD TGFB1 VEGFA CTGF EDN1
7 digestive/alimentary MP:0005381 10.15 CTGF EDN1 ICAM1 IFNG IL13 IL4
8 integument MP:0010771 10.02 CD34 CTGF ICAM1 IFNG IL13 IL4
9 neoplasm MP:0002006 9.91 VEGFA CD34 ELANE ICAM1 IFNG PTPRC
10 respiratory system MP:0005388 9.77 TGFB1 VEGFA CTGF GREM1 IFNG IL13
11 renal/urinary system MP:0005367 9.76 EDN1 GREM1 IFNG IL4 PTPRC SERPINE1
12 skeleton MP:0005390 9.28 IL13 IL4 PTPRC TGFB1 VEGFA CTGF

Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

Drugs for Idiopathic Interstitial Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2 147536-97-8 104865
2
Nintedanib Approved Phase 4,Phase 3,Phase 2 656247-17-5 56843413
3
Pirfenidone Investigational Phase 4,Phase 3,Phase 2,Phase 1 53179-13-8 40632
4 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2,Phase 3
5 Phosphodiesterase Inhibitors Phase 4,Phase 2,Phase 3
6 Sildenafil Citrate Phase 4,Phase 2,Phase 3 171599-83-0
7 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Antihypertensive Agents Phase 4,Phase 3,Phase 2
9 Endothelin Receptor Antagonists Phase 4,Phase 3,Phase 2
10 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
11 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
14 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Citrate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
17
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 77-92-9 311
18
Sulfamethoxazole Approved Phase 3 723-46-6 5329
19
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
20
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
21
Treprostinil Approved, Investigational Phase 3,Phase 2 81846-19-7 54786 6918140
22
Iloprost Approved, Investigational Phase 2, Phase 3 78919-13-8 6443959
23
Acetylcysteine Approved, Investigational Phase 3,Phase 2,Phase 1 616-91-1 12035
24
Azathioprine Approved Phase 3,Phase 1,Phase 2 446-86-6 2265
25
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
26
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
27
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 83-43-2 6741
28
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 50-24-8 5755
29
Losartan Approved Phase 2, Phase 3 114798-26-4 3961
30
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
31
Mycophenolic acid Approved Phase 3 24280-93-1 446541
32
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
33
Lenograstim Approved Phase 3 135968-09-1
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
35
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
36
Warfarin Approved Phase 3 81-81-2 6691 54678486
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
39 Anti-Bacterial Agents Phase 3,Phase 2
40 Anti-Infective Agents Phase 3,Phase 2,Phase 1
41 Antimalarials Phase 3,Phase 2
42 Antiparasitic Agents Phase 3,Phase 2
43 Antiprotozoal Agents Phase 3,Phase 2
44 Cytochrome P-450 Enzyme Inhibitors Phase 3
45 Folic Acid Antagonists Phase 3,Phase 2
46 Renal Agents Phase 3
47 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
48 Vitamin B Complex Phase 3,Phase 2
49 Platelet Aggregation Inhibitors Phase 2, Phase 3
50 Immunosuppressive Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 264)
id Name Status NCT ID Phase
1 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With Sildenafil Unknown status NCT00625079 Phase 4
2 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan Unknown status NCT00625469 Phase 4
3 Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients Unknown status NCT01382368 Phase 4
4 Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study Unknown status NCT00637065 Phase 4
5 Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT02598193 Phase 4
6 Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPF Completed NCT02579603 Phase 4
7 A Study to Compare the Amount of Nintedanib and Pirfenidone in the Blood When Nintedanib and Pirfenidone Are Given Separately or in Combination Completed NCT02606877 Phase 4
8 Effect of Nintedanib on Biomarkers of Extracellular Matrix Turnover in Patients With Idiopathic Pulmonary Fibrosis and Limited Forced Vital Capacity Impairment Recruiting NCT02788474 Phase 4
9 Pirfenidone in Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis Not yet recruiting NCT02821689 Phase 4
10 68Ga-DOTA-NOC PET/CT in Patients With Idiopathic Pulmonary Fibrosis Terminated NCT01321996 Phase 4
11 Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole Unknown status NCT01777737 Phase 3
12 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3
13 Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial Hypertension Unknown status NCT00705133 Phase 3
14 Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary Fibrosis Unknown status NCT00439543 Phase 2, Phase 3
15 Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide Completed NCT00600028 Phase 3
16 Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443 Completed NCT00631475 Phase 3
17 Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00071461 Phase 2, Phase 3
18 Efficacy and Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT01366209 Phase 3
19 Three-Arm Study of the Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00287716 Phase 3
20 Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00287729 Phase 3
21 Gleevec Idiopathic Pulmonary Fibrosis (IPF) Study Completed NCT00131274 Phase 2, Phase 3
22 Targeting Vascular Reactivity in Idiopathic Pulmonary Fibrosis Completed NCT00981747 Phase 2, Phase 3
23 Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis Completed NCT00517933 Phase 3
24 Open-Label Study of the Long Term Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00662038 Phase 3
25 A Study of the Safety and Efficacy Interferon-Gamma 1b in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00047645 Phase 3
26 Study of the Effects of High-dose N-acetylcysteine (NAC) in Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00639496 Phase 3
27 BUILD 3: Bosentan Use in Interstitial Lung Disease Completed NCT00391443 Phase 3
28 Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients Completed NCT01335464 Phase 3
29 Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients II Completed NCT01335477 Phase 3
30 Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF Completed NCT00650091 Phase 3
31 A Study of Mycophenolate Mofetil (CellCept) in Lung Transplant Recipients Completed NCT01014442 Phase 3
32 Rituximab in Rheumatoid Arthritis Lung Disease Completed NCT00578565 Phase 3
33 High Dose Cyclophosphamide for Treatment of Scleroderma Completed NCT00501995 Phase 3
34 EZ-2053 in the Prophylaxis of Acute Pulmonary Allograft Rejection Completed NCT00105183 Phase 3
35 Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma Completed NCT00070590 Phase 2, Phase 3
36 Clinical Study of ART-123 for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis Recruiting NCT02739165 Phase 3
37 Cyclophosphamide for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Recruiting NCT02460588 Phase 3
38 Efficacy and Safety of Nintedanib When Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment Recruiting NCT02802345 Phase 3
39 Nebulized Fentanyl in Patients With Mild to Moderate Idiopathic Pulmonary Fibrosis and Chronic Dyspnea Recruiting NCT03018756 Phase 3
40 A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis Recruiting NCT02597933 Phase 3
41 Extension Trial of the Long Term Safety of BIBF 1120 in Patients With Idiopathic Pulmonary Fibrosis Active, not recruiting NCT01619085 Phase 3
42 Phase III Study on Rotavirus Vaccine to Evaluate Lot-to-lot Consistency and Interference With Routine UIP Immunization Active, not recruiting NCT02584816 Phase 3
43 CleanUP IPF for the Pulmonary Trials Cooperative Not yet recruiting NCT02759120 Phase 3
44 Pirfenidone as Treatment of Skin Fibrosis in Systemic Sclerosis Not yet recruiting NCT03068234 Phase 2, Phase 3
45 ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis Terminated NCT00879229 Phase 3
46 AntiCoagulant Effectiveness in Idiopathic Pulmonary Fibrosis Terminated NCT00957242 Phase 3
47 Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF) Terminated NCT01979952 Phase 3
48 (ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF Terminated NCT00768300 Phase 3
49 The INSPIRE Trial: A Study of Interferon Gamma-1b for Idiopathic Pulmonary Fibrosis (IPF) Terminated NCT00075998 Phase 3
50 A Randomized, Double-Blind, Three-Arm, Phase 3b Study Comparing the Safety and Efficacy of Interferon Gamma-1b With Azathioprine, and Azathioprine Alone in Patients With IPF Receiving Prednisone Terminated NCT00052039 Phase 3

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pulmonary fibrosis

Genetic Tests for Idiopathic Interstitial Pneumonia

Anatomical Context for Idiopathic Interstitial Pneumonia

MalaCards organs/tissues related to Idiopathic Interstitial Pneumonia:

39
Lung, Testes, Bone, Colon, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Idiopathic Interstitial Pneumonia:

18
The Lung Parenchyma Of Unknown Cause

Publications for Idiopathic Interstitial Pneumonia

Articles related to Idiopathic Interstitial Pneumonia:

(show top 50) (show all 139)
id Title Authors Year
1
Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias. ( 26699835 )
2016
2
Postoperative pyothorax a risk factor for acute exacerbation of idiopathic interstitial pneumonia following lung cancer resection. ( 27277761 )
2016
3
Idiopathic interstitial pneumonia-associated pulmonary hypertension: A target for therapy? ( 27884593 )
2016
4
Idiopathic pleuroparenchymal fibroelastosis, a new idiopathic interstitial pneumonia: A case report. ( 26810762 )
2016
5
A Multidisciplinary Evaluation Helps Identify the Antisynthetase Syndrome in Patients Presenting as Idiopathic Interstitial Pneumonia. ( 26932342 )
2016
6
Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. ( 26792595 )
2016
7
Clinical Implication of Proteinase-3-antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias. ( 26873743 )
2016
8
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
9
Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis. ( 27564852 )
2016
10
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. ( 27266705 )
2016
11
Incidence and prevalence of idiopathic interstitial pneumonia and idiopathic pulmonary fibrosis in Korea. ( 27287654 )
2016
12
Idiopathic pleuroparenchymal fibroelastosis - A rare idiopathic interstitial pneumonia. ( 27141432 )
2016
13
Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia. ( 28079842 )
2016
14
Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia. ( 27460223 )
2016
15
The pathological features of idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas. ( 27757985 )
2016
16
Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer. ( 26792177 )
2016
17
Scoring of the radiological picture of idiopathic interstitial pneumonia: a study to verify the reliability of the method. ( 26600944 )
2015
18
Newly Detected Pulmonary Nontuberculous Mycobacterial Infection and Peripheral Lung Cancers in Patients During Follow-Up of Idiopathic Interstitial Pneumonia: Comparison of CT Findings. ( 25837763 )
2015
19
Pulmonary Resection for Lung Cancer in Patients With Idiopathic Interstitial Pneumonia. ( 26116477 )
2015
20
Idiopathic interstitial pneumonia in the ICU: an observational cohort. ( 26603794 )
2015
21
Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. ( 26231557 )
2015
22
The correlation of symptoms, pulmonary function tests and exercise testing with high-resolution computed tomography in patients with idiopathic interstitial pneumonia in a tertiary care hospital in South India. ( 26664164 )
2015
23
Symptom-based management of the idiopathic interstitial pneumonia. ( 26450007 )
2015
24
Smoking-related idiopathic interstitial pneumonia: A review. ( 26138798 )
2015
25
Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia. ( 26416262 )
2015
26
Role of I+1 and I+2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts. ( 26006016 )
2015
27
Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs. ( 26539479 )
2015
28
SFTPA2 Mutations in Familial and Sporadic Idiopathic Interstitial Pneumonia. ( 26568241 )
2015
29
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. ( 25682542 )
2015
30
Evolving Early Lung Cancers Detected During Follow-Up of Idiopathic Interstitial Pneumonia: Serial CT Features. ( 26001227 )
2015
31
Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia. ( 24937643 )
2014
32
Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients. ( 24613046 )
2014
33
Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia - short term evaluation of safety and tolerability. ( 24886036 )
2014
34
Connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonia: similarity and difference. ( 24480141 )
2014
35
The pandemic influenza A (H1N1) 2009 vaccine does not increase the mortality rate of idiopathic interstitial pneumonia: a matched case-control study. ( 24586445 )
2014
36
Viral infections in patients with an acute exacerbation of idiopathic interstitial pneumonia. ( 24388373 )
2014
37
Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia. ( 24033388 )
2014
38
Smoking-related idiopathic interstitial pneumonia. ( 25063244 )
2014
39
Low-normal lung volume correlates with pulmonary hypertension in fibrotic idiopathic interstitial pneumonia: computer-aided 3D quantitative analysis of chest CT. ( 25055292 )
2014
40
Physical activity in daily life of patients with fibrotic idiopathic interstitial pneumonia. ( 23928896 )
2013
41
MMP-7 and fcDNA Serum Levels in Early NSCLC and Idiopathic Interstitial Pneumonia: Preliminary Study. ( 24336111 )
2013
42
Immunohistochemical detection of virus through its nuclear cytopathic effect in idiopathic interstitial pneumonia other than acute exacerbation. ( 24270907 )
2013
43
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. ( 23678265 )
2013
44
Limitations to the 6-minute walk test in dermatomyositis with interstitial lung disease in comparison with idiopathic interstitial pneumonia. ( 23400027 )
2013
45
Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia. ( 22212399 )
2012
46
Chemotherapy for non-small cell lung cancer complicated by idiopathic interstitial pneumonia. ( 23741246 )
2012
47
Significance of connective tissue disease features in idiopathic interstitial pneumonia. ( 21920896 )
2012
48
Lung capillary blood volume and membrane diffusion in idiopathic interstitial pneumonia. ( 22221584 )
2012
49
High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. ( 23364926 )
2012
50
Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients. ( 23106582 )
2012

Variations for Idiopathic Interstitial Pneumonia

Expression for Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for Idiopathic Interstitial Pneumonia

Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show all 49)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CCL2 CD34 CXCL8 ELANE ICAM1 IFNG
2
Show member pathways
13.56 CCL2 CTGF CXCL8 ICAM1 IFNG IL13
3
Show member pathways
13.37 CCL2 CXCL8 ICAM1 IFNG IL13 IL4
4
Show member pathways
13.31 CCL2 CTGF CXCL8 IL13 IL4 PTPRC
5
Show member pathways
12.9 CCL2 CXCL8 IFNG SERPINE1 SFTPA2 SFTPD
6
Show member pathways
12.83 CXCL8 ICAM1 IFNG IL13 IL4 TGFB1
7
Show member pathways
12.81 CCL2 CXCL8 ICAM1 IFNG IL13 IL4
8 12.55 CCL2 CD34 IFNG IL4 PTPRC
9
Show member pathways
12.33 CCL2 ICAM1 IFNG IL4 SERPINE1
10
Show member pathways
12.32 CCL2 CXCL8 IFNG IL13 IL4 MUC5B
11
Show member pathways
12.18 CXCL8 IFNG IL4 SFTPA1 SFTPD
12
Show member pathways
12.16 CXCL8 IFNG IL13 IL4
13 12.08 CCL2 EDN1 ICAM1 IFNG VEGFA
14 12.02 CD34 IFNG IL4 PTPRC
15 11.96 CXCL8 IFNG SERPINE1 TGFB1
16 11.96 CCL2 CXCL8 ICAM1 IFNG IL4 TGFB1
17 11.91 EDN1 IFNG SERPINE1 VEGFA
18
Show member pathways
11.89 SFTPA1 SFTPA2 SFTPC SFTPD
19 11.82 CCL2 GREM1 TGFB1
20 11.79 CXCL8 ICAM1 IFNG IL13 IL4
21 11.77 CD34 IFNG PTPRC TGFB1
22
Show member pathways
11.76 CXCL8 IFNG IL4
23 11.76 CXCL8 SFTPA1 SFTPA2
24 11.76 CD34 IFNG IL13 IL4 PTPRC
25 11.76 CCL2 CXCL8 ICAM1 IL13 IL4 TGFB1
26 11.72 ICAM1 IL4 TGFB1
27 11.69 CCL2 CXCL8 ICAM1 IFNG TGFB1 VEGFA
28 11.68 EDN1 SERPINE1 VEGFA
29
Show member pathways
11.66 CXCL8 ICAM1 IFNG VEGFA
30 11.62 IFNG SERPINE1 TGFB1
31 11.57 CXCL8 TGFB1 VEGFA
32 11.54 CTGF ELANE ICAM1
33 11.52 IFNG IL13 IL4
34
Show member pathways
11.51 SFTPA1 SFTPA2 SFTPD
35 11.5 CCL2 CXCL8 EDN1 ICAM1 SERPINE1 TGFB1
36 11.49 CXCL8 ICAM1 IFNG
37
Show member pathways
11.46 SFTPA1 SFTPA2 SFTPC SFTPD
38 11.46 CCL2 CXCL8 ICAM1 IL13 IL4
39 11.41 CCL2 CXCL8 ICAM1 IFNG TGFB1
40 11.4 EDN1 SERPINE1 VEGFA
41 11.32 IFNG IL13 IL4
42 11.27 IFNG IL13 IL4 TGFB1
43 11.25 IFNG IL13 TGFB1
44 11.22 CCL2 CXCL8 IL13 IL4
45 11.21 IFNG IL13 IL4
46 11.2 CCL2 CTGF CXCL8 EDN1 GREM1 IL13
47 11.19 CCL2 ICAM1 IFNG
48
Show member pathways
11.13 SFTPA1 SFTPA2 SFTPC SFTPD
49 10.93 IL13 IL4 TGFB1

GO Terms for Idiopathic Interstitial Pneumonia

Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 CD34 ELANE GREM1 ICAM1 PTPRC TGFB1
2 extracellular region GO:0005576 9.91 CCL2 CD34 CTGF CXCL8 EDN1 ELANE
3 proteinaceous extracellular matrix GO:0005578 9.88 CTGF SFTPA1 SFTPA2 SFTPD TGFB1 VEGFA
4 external side of plasma membrane GO:0009897 9.8 CD34 ICAM1 IFNG IL13 IL4 PTPRC
5 secretory granule GO:0030141 9.63 ELANE TGFB1 VEGFA
6 platelet alpha granule lumen GO:0031093 9.61 SERPINE1 TGFB1 VEGFA
7 extracellular space GO:0005615 9.58 CCL2 CTGF CXCL8 EDN1 ELANE GREM1
8 clathrin-coated endocytic vesicle GO:0045334 9.56 SFTPA1 SFTPA2 SFTPC SFTPD
9 lamellar body GO:0042599 9.46 SFTPA1 SFTPA2 SFTPC SFTPD

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.99 CCL2 EDN1 ICAM1 IFNG IL4 TGFB1
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL2 CTGF ICAM1 TGFB1
3 positive regulation of cell proliferation GO:0008284 9.98 CTGF EDN1 GREM1 IFNG IL4 TGFB1
4 negative regulation of gene expression GO:0010629 9.97 CD34 CTGF IFNG TGFB1
5 regulation of immune response GO:0050776 9.97 CD34 ICAM1 IFNG IL4 SFTPD
6 response to lipopolysaccharide GO:0032496 9.96 CCL2 EDN1 ELANE ICAM1 IL13
7 response to organic cyclic compound GO:0014070 9.93 CTGF ICAM1 IL4 TGFB1
8 response to hypoxia GO:0001666 9.93 CCL2 EDN1 ICAM1 TGFB1 VEGFA
9 response to ethanol GO:0045471 9.92 CCL2 ICAM1 IL13 IL4
10 cellular response to tumor necrosis factor GO:0071356 9.91 CCL2 CXCL8 EDN1 ICAM1
11 movement of cell or subcellular component GO:0006928 9.9 CXCL8 IFNG IL13
12 response to wounding GO:0009611 9.89 CCL2 CTGF TGFB1
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 ICAM1 IL4 TGFB1 VEGFA
14 positive regulation of T cell proliferation GO:0042102 9.87 IFNG IL4 PTPRC
15 cellular response to interferon-gamma GO:0071346 9.87 CCL2 EDN1 ICAM1
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 EDN1 ELANE IL13
17 cellular response to interleukin-1 GO:0071347 9.85 CCL2 CXCL8 EDN1 ICAM1
18 positive regulation of protein phosphorylation GO:0001934 9.85 CTGF IFNG IL4 TGFB1 VEGFA
19 positive regulation of cell adhesion GO:0045785 9.84 CCL2 IFNG VEGFA
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNG IL4 VEGFA
21 toll-like receptor signaling pathway GO:0002224 9.83 SFTPA1 SFTPA2 SFTPD
22 neutrophil chemotaxis GO:0030593 9.83 CCL2 CXCL8 EDN1 IFNG
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 EDN1 ICAM1 IFNG
24 positive regulation of B cell proliferation GO:0030890 9.8 IL13 IL4 PTPRC
25 cellular response to dexamethasone stimulus GO:0071549 9.8 CCL2 ICAM1 TGFB1
26 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL8 ICAM1 IFNG SERPINE1
27 positive regulation of MAP kinase activity GO:0043406 9.78 EDN1 ELANE TGFB1 VEGFA
28 positive regulation of collagen biosynthetic process GO:0032967 9.77 CCL2 CTGF TGFB1
29 positive regulation of protein complex assembly GO:0031334 9.77 IFNG TGFB1 VEGFA
30 positive regulation of angiogenesis GO:0045766 9.77 CD34 CXCL8 GREM1 SERPINE1 VEGFA
31 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.74 GREM1 TGFB1 VEGFA
32 PERK-mediated unfolded protein response GO:0036499 9.73 CCL2 CXCL8
33 angiogenesis GO:0001525 9.73 CCL2 CTGF CXCL8 GREM1 SERPINE1 VEGFA
34 leukocyte migration involved in inflammatory response GO:0002523 9.72 CCL2 ELANE
35 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TGFB1
36 maternal process involved in parturition GO:0060137 9.72 CCL2 EDN1
37 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IFNG IL4
38 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IFNG IL4
39 positive regulation of mast cell degranulation GO:0043306 9.71 IL13 IL4
40 positive regulation of cardiac muscle cell differentiation GO:2000727 9.7 GREM1 TGFB1
41 surfactant homeostasis GO:0043129 9.7 SFTPD VEGFA
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IFNG IL4
43 positive regulation of cellular extravasation GO:0002693 9.68 CCL2 ICAM1
44 acute inflammatory response to antigenic stimulus GO:0002438 9.68 ELANE ICAM1
45 positive regulation of immunoglobulin production GO:0002639 9.68 IL13 IL4
46 negative regulation of blood coagulation GO:0030195 9.67 CD34 EDN1 SERPINE1
47 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.65 GREM1 VEGFA
48 regulation of proton transport GO:0010155 9.64 IL13 IL4
49 positive regulation of mononuclear cell migration GO:0071677 9.64 IL4 TGFB1
50 response to amino acid GO:0043200 9.62 CCL2 CTGF EDN1 ICAM1

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.62 CD34 SFTPA1 SFTPA2 SFTPD
2 growth factor activity GO:0008083 9.46 CTGF IL4 TGFB1 VEGFA
3 cytokine activity GO:0005125 9.28 CCL2 CXCL8 EDN1 GREM1 IFNG IL13
4 vascular endothelial growth factor receptor 2 binding GO:0043184 9.26 GREM1 VEGFA
5 heparin binding GO:0008201 9.26 CCL2 CTGF ELANE VEGFA

Sources for Idiopathic Interstitial Pneumonia

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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