Idiopathic Interstitial Pneumonia malady

Wikipedia: Idiopathic interstitial pneumonia (IIP), or noninfectious pneumoniaare a class of diffuse lung diseases....⁴⁴ more...

MalaCards: Idiopathic Interstitial Pneumonia, also known as diffuse idiopathic pulmonary fibrosis, is related to respiratory failure and nonspecific interstitial pneumonia. An important gene associated with Idiopathic Interstitial Pneumonia is ASCL1 (achaete-scute complex homolog 1 (Drosophila)), and among its related pathways are Regulation of eIF4 and p70S6K and Actin-Based Motility by Rho Family GTPases. The compounds sp 600125 and nicotine have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause and lung, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Disease Ontology: A pneumonia located in the lung parenchyma of unknown cause.⁶

Aliases & Descriptions:

idiopathic interstitial pneumonia 6 diffuse idiopathic pulmonary fibrosis 6

idiopathic fibrosing alveolitis 6 hamman-rich syndrome 43

Diseases related to idiopathic interstitial pneumonia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 470)

id	Related Disease	Score	Top Affiliating Genes
1	respiratory failure	30.1	SFTPD, CMA1, SCGB1A1, IL13, ELANE
2	nonspecific interstitial pneumonia	29.6	SFTPC, IL13, IL8, CCL2, TGFB1
3	idiopathic pulmonary fibrosis	28.7	IL8, EDN1, TGFB1
4	usual interstitial pneumonia	28.7	SFTPC, IL13, IL8, CCL2, TGFB1
5	acute interstitial pneumonia	28.3	SFTPC, SFTPD, SCGB1A1, ASCL1, IL13, IL13RA1
6	pneumonia	25.0	SFTPC, SFTPD, SERPINE1, VEGFA, CMA1, BDNF
7	large cell carcinoma	13.3	SFTPC, SFTPD, THBD
8	hyper-ige syndrome	13.2	IL13, IL4R, TLR9
9	lipoid nephrosis	13.2	IL13, IL4R, CCL2
10	neovascular glaucoma	13.1	VEGFA, TGFB2
11	stevens-johnson syndrome	13.1	IL13, IL4R, TLR9
12	cerebral malaria	13.0	ICAM1, THBS1, TGIF1
13	lung benign neoplasm	13.0	SFTPC, SFTPD, SCGB1A1, IL4R
14	connective tissue disease	12.9	SFTPD, CTGF, EDN1
15	collagen disease	12.9	SFTPD, VEGFA, THBD
16	thrombotic thrombocytopenic purpura, acquired	12.9	SERPINE1, THBD, THBS1
17	pulmonary sarcoidosis	12.9	SFTPD, CCL2, ICAM1
18	diabetic polyneuropathy	12.9	VEGFA, NTF3, THBD
19	cerebral aneurysms	12.9	CCL2, EDN1, ELANE
20	pulmonary eosinophilia	12.9	SFTPD, IL13, IL8
21	molluscum contagiosum	12.9	IL8, KRT14, TLR9
22	venous insufficiency	12.9	SERPINE1, KRT14, ELANE
23	pulmonary hypertension	12.9	SFTPC, EDN1, ELANE, THBD
24	protein c deficiency	12.8	SFTPC, SERPINE1, THBD
25	chronic sphenoidal sinusitis	12.8	IL13, IL8, ELANE
26	adult respiratory distress syndrome	12.8	IL8, ELANE, THBD
27	burkitt's lymphoma	12.8	IL13RA2, IL4R, ICAM1, TLR9
28	carpal tunnel syndrome	12.8	VEGFA, CCL2, TGIF1
29	diffuse panbronchiolitis	12.8	IL13, IL8, ELANE
30	panbronchiolitis	12.8	IL13, IL8, ELANE
31	venous tributary occlusion of retina	12.8	SERPINE1, EDN1, THBD
32	mesangial proliferative glomerulonephritis	12.7	VEGFA, CCL2, EDN1
33	non-small cell lung carcinoma	12.7	SFTPC, SFTPD, VEGFA, IL4R
34	mycosis fungoides	12.7	IL13, CCR7, ICAM1, TLR9
35	obstructive lung disease	12.7	SFTPC, ELANE, TGFB1
36	pulmonary alveolar proteinosis	12.7	SFTPC, SFTPD, IL8, CCL2
37	brain cancer	12.7	VEGFA, IL13, IL13RA1, IL13RA2, IL4R
38	thromboangiitis obliterans	12.7	SERPINE1, ICAM1, EDN1
39	viral encephalitis	12.7	VEGFA, CCL2, ICAM1
40	ureteral disease	12.7	CCL2, CTGF, TGFB1
41	crohn's disease	12.6	IL13, IL13RA2, IL8, TLR9
42	allergic conjunctivitis	12.6	IL13, IL8, ICAM1
43	hernia	12.6	SCGB1A1, CCL2, EDN1, ELANE
44	intermittent claudication	12.6	SERPINE1, EDN1, THBD
45	peyronies disease	12.6	CCL2, TGFB1, POSTN
46	immunodeficiency	12.6	IL13, IL4R, CCR7, KRT14, TLR9, TGFB2
47	hemangioendothelioma	12.6	VEGFA, CCL2, EDN1
48	endophthalmitis	12.6	VEGFA, IL8, ELANE
49	eosinophilic pneumonia	12.6	SFTPD, IL13, IL8, CCL2
50	classic kaposi sarcoma	12.6	VEGFA, IL13, IL8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to idiopathic interstitial pneumonia:

²²

FMA organs/tissues related to idiopathic interstitial pneumonia:

¹¹

MGI Mouse Phenotypes related to idiopathic interstitial pneumonia:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	ASCL1, POSTN
2	immune system phenotype	MP:0005387	9.8	CMA1, KRT14, ELANE, THBS1, POSTN
3	hematopoietic system phenotype	MP:0005397	9.8	TLR9, CCR7, IL4R, IL13RA2, IL13RA1
4	renal/urinary system phenotype	MP:0005367	9.7	TGFB2, THBS1, GREM1, SCGB1A1
5	integument phenotype	MP:0010771	9.5	KRT14, IL4R, IL13, ASCL1, BDNF
6	respiratory system phenotype	MP:0005388	9.3	NTF3, IL13RA1, GREM1, ASCL1, SCGB1A1, BDNF
7	craniofacial phenotype	MP:0005382	9.3	POSTN, TGIF1, EDN1, GREM1, ASCL1, BDNF
8	limbs/digits/tail phenotype	MP:0005371	8.6	TGIF1, TGFB2, THBS1, CTGF, GREM1, VEGFA
9	reproductive system phenotype	MP:0005389	8.0	POSTN, TGFB1, THBS1, KRT14, CCL2, IL13
10	nervous system phenotype	MP:0003631	7.8	TGIF1, TGFB2, TGFB1, THBD, EDN1, NTF3
11	tumorigenesis	MP:0002006	7.5	POSTN, TGFB1, THBS1, ELANE, KRT14, ICAM1
12	growth/size phenotype	MP:0005378	7.4	CTGF, NTF3, THBD, THBS1, TGFB2, POSTN
13	digestive/alimentary phenotype	MP:0005381	7.4	TGFB2, TGFB1, THBS1, EDN1, KRT14, CTGF
14	muscle phenotype	MP:0005369	6.9	POSTN, TGFB2, TGFB1, THBS1, EDN1, NTF3
15	vision/eye phenotype	MP:0005391	6.7	TGFB2, TGFB1, THBS1, KRT14, NTF3, CTGF
16	mortality/aging	MP:0010768	6.1	THBD, TLR9, ELANE, EDN1, TGFB2, KRT14
17	cardiovascular system phenotype	MP:0005385	6.0	THBD, THBS1, TGFB1, TGFB2, TGIF1, POSTN
18	cellular phenotype	MP:0005384	5.5	KRT14, TLR9, THBD, THBS1, TGFB1, TGFB2
19	homeostasis/metabolism phenotype	MP:0005376	3.7	SFTPD, NTF3, KRT14, EDN1, ELANE, TLR9

Articles related to idiopathic interstitial pneumonia:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. (21177844)	Okamoto M.... Aizawa H.	2011	POSTN
2	TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. (18633634)	Meneghin A.... Hogaboam C.M.	2008	IL13, TLR9
3	High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia. (18640828)	Ide M.... Kohno S.	2008	THBS1
4	Assessment of gene transcription demonstrates connection with the clinical course of idiopathic interstitial pneumonia. (18525195)	Golec M.... Ziesche R.	2008	TGFB1, CTGF, IL13
5	Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. (18072275)	Myllarniemi M.... Kinnula V.	2008	GREM1
6	Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. (17334631)	Hirata K.... Ueda M.	2007	CMA1
7	CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. (17469163)	Prasse A.... Muller-Quernheim J.	2007	CCL18
8	Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. (17005585)	Markart P.... Witt H.	2007	SFTPC
9	Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. (18069415)	Ricci A.... Mariotta S.	2007	BDNF, NTF3
10	Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy (16502863)	Imokawa S.... Chida K.	2006	ELANE
11	Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia. (16394278)	Choi E.S.... Hogaboam C.M.	2006	CCR7
12	Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. (15161635)	Jakubzick C.... Hogaboam C.M.	2004	IL13, IL4R, IL13RA1
13	Angiogenic cytokines in patients with idiopathic interstitial pneumonia. (15223865)	Simler N.R.... Egan J.J.	2004	VEGFA, IL8, EDN1
14	Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. (15113854)	Jakubzick C.... Hogaboam C.M.	2004	IL13, IL13RA1, IL13RA2
15	Phenotype of regenerative epithelium in idiopathic interstitial pneumonias. (15074359)	Hinata N.... Koike M.	2003	TGFB2, KRT14, SCGB1A1
16	A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia. (12765340)	Kim K.K.... Simon R.H.	2003	SERPINE1
17	Idiopathic interstitial pneumonia following stem cell transplantation. (12868990)	Yamaguchi N.... Hara H.	2003	THBD
18	Modulation of pulmonary neuroendocrine cells in idiopathic interstitial pneumonia. (12371140)	Ito T.... Kitamura H.	2002	ASCL1
19	Intercellular adhesion molecule-1 in patients with idiopathic interstitial pneumonia. (11512562)	Takehara H.... Harada M.	2001	ICAM1
20	Clinical significance of serum surfactant proteins A and D in idiopathic interstitial pneumonia (9216212)	Honda Y.	1996	SFTPD
21	Role of alveolar macrophages in the pathogenesis of idiopathic interstitial pneumonia (9216211)	Suga M.... Ando M.	1996	CCL2
22	Evaluation of the elastase burden in patients with idiopathic interstitial pneumonia (8255016)	Kamei T.... Takahara J.	1993	ELANE

Genes related to idiopathic interstitial pneumonia according to GeneCards:

(show all 30)

id	Symbol	Description	Score	GeneCards Section Context
1	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
2	IL13RA1	interleukin 13 receptor, alpha 1	11.0	Publications
3	GREM1	gremlin 1	11.0	Publications
4	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
5	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
6	POSTN	periostin, osteoblast specific factor	11.0	Publications
7	IL13RA2	interleukin 13 receptor, alpha 2	11.0	Publications
8	SFTPC	surfactant protein C	11.0	Publications
9	CMA1	chymase 1, mast cell	11.0	Publications
10	KRT14	keratin 14	11.0	Publications
11	SFTPD	surfactant protein D	11.0	Publications
12	CCR7	chemokine (C-C motif) receptor 7	11.0	Publications
13	THBS1	thrombospondin 1	11.0	Publications
14	NTF3	neurotrophin 3	11.0	Publications
15	CTGF	connective tissue growth factor	11.0	Publications
16	IL4R	interleukin 4 receptor	11.0	Publications
17	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
18	TLR9	toll-like receptor 9	11.0	Publications
19	THBD	thrombomodulin	11.0	Publications
20	TGFB2	transforming growth factor, beta 2	11.0	Publications
21	ELANE	elastase, neutrophil expressed	11.0	Publications
22	IL13	interleukin 13	11.0	Publications
23	BDNF	brain-derived neurotrophic factor	11.0	Publications
24	EDN1	endothelin 1	11.0	Publications
25	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
26	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
27	ICAM1	intercellular adhesion molecule 1	11.0	Publications
28	VEGFA	vascular endothelial growth factor A	11.0	Publications
29	IL8	interleukin 8	11.0	Publications
30	TGFB1	transforming growth factor, beta 1	11.0	Publications

Pathways related to idiopathic interstitial pneumonia according to GeneDecks:

(show top 50)    (show all 63)

id	Pathway	Score	Top Affiliating Genes
1	Regulation of eIF4 and p70S6K36	10.1	IL13, CCL18, NTF3
2	Actin-Based Motility by Rho Family GTPases36	10.1	BDNF, CTGF
3	Telomerase Components in Cell Signaling36	10.0	NTF3, CTGF, BDNF
4	PPAR Pathway36	10.0	CTGF, NTF3, TGFB2
5	Selected targets of C/EBPalpha10	10.0	ELANE, SCGB1A1, SFTPD
6	Glioma Invasiveness36	10.0	BDNF, NTF3, TGFB2
7	JNK Pathway36	9.9	TGFB1, NTF3, IL4R
8	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL4R, TGFB1, TGFB2
9	eIF2 Pathway36	9.7	TGFB2, NTF3, CTGF, BDNF
10	Endothelin-1 Signaling Pathway36	9.5	EDN1, CCL18, IL13
11	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	TGFB2, TGFB1, IL4R, IL13
12	Paxillin Interactions36	9.4	TGFB2, NTF3, CTGF, BDNF
13	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	TGFB2, TGFB1, TLR9, CCR7, IL4R
14	ERK Signaling36	9.4	TGFB2, TGFB1, CTGF, CCL18, IL13
15	PGC1Alpha Pathway36	9.3	CCL18, IL8, IL4R, IL13
16	Apoptotic Pathways in Synovial Fibroblasts36	9.3	TGFB2, TGFB1, NTF3, CTGF, BDNF
17	p53 Mediated Apoptosis36	9.3	TGFB2, TGFB1, NTF3, CTGF, BDNF
18	TGF-beta/Smad Signaling3	9.2	TGFB2, TGFB1, GREM1
19	Mitochondrial Apoptosis36	9.2	BDNF, CTGF, NTF3, TGFB1, TGFB2
20	DHA Signaling36	9.2	TGFB2, TGFB1, NTF3, CTGF, BDNF
21	mTOR Pathway36	9.2	TGFB2, TGFB1, NTF3, CTGF, BDNF
22	ERK5 Signaling36	9.2	BDNF, CTGF, NTF3, TGFB1, TGFB2
23	Cellular Apoptosis Pathway36	9.2	TGFB2, TGFB1, NTF3, CTGF, BDNF
24	Nanog in Mammalian ESC Pluripotency36	9.1	BDNF, CTGF, NTF3, TGFB1, TGFB2
25	Nuclear Receptor Activation by Vitamin-A36	9.1	TGFB2, TGFB1, NTF3, CTGF, BDNF
26	Rac1 Pathway36	9.1	TGFB2, TGFB1, NTF3, CTGF, BDNF
27	Akt Signaling36	9.1	TGFB2, NTF3, CTGF, CCR7, CCL18, CCL2
28	p70S6K Signaling36	9.0	TGFB2, TGFB1, NTF3, CTGF, IL4R, BDNF
29	NF-KappaB (p50-p65) Pathway36	9.0	TGFB2, TGFB1, TLR9, NTF3, CTGF, BDNF
30	NF-KappaB Family Pathway36	9.0	TGFB2, TGFB1, TLR9, NTF3, CTGF, BDNF
31	IP3 Pathway36	9.0	BDNF, CTGF, NTF3, TGFB1, TGFB2
32	Activation of PKC through GPCR36	9.0	TGFB2, TGFB1, NTF3, CTGF, BDNF
33	14-3-3 Induced Intracellular Signaling36	8.9	BDNF, CTGF, NTF3, TGFB1, TGFB2
34	Renin-Angiotensin Pathway36	8.9	TGFB2, TGFB1, NTF3, CTGF, CCL2, BDNF
35	PEDF Induced Signaling36	8.8	BDNF, IL13, IL8, CCL2, CCL18
36	STAT3 Pathway36	8.5	CCR7, CCL18, CCL2, IL8, IL4R, IL13RA2
37	Glucocorticoid Receptor Signaling36	8.4	TGFB1, CCL18, CCL2, IL8, IL4R, IL13
38	Chagas disease (American trypanosomiasis)20	8.1	TGFB2, TGFB1, TLR9, CCL2, IL8, SERPINE1
39	Molecular Mechanisms of Cancer36	8.1	CTGF, NTF3, TGFB1, TGFB2, CCR7, CCL18
40	Malaria20	7.9	TGFB2, TGFB1, THBS1, TLR9, ICAM1, CCL2
41	Rheumatoid arthritis20	7.7	TGFB2, TGFB1, ICAM1, CCL2, IL8, VEGFA
42	PAK Pathway36	7.6	TGFB2, TGFB1, NTF3, CTGF, CCL18, CCL2
43	Rho Family GTPases36	7.6	TGFB2, TGFB1, NTF3, CTGF, CCL18, CCL2
44	TGF-Beta Pathway36	7.4	TGFB2, TGFB1, NTF3, CTGF, CCL18, CCL2
45	JAK-STAT Pathway36	7.4	CTGF, NTF3, TGFB1, TGFB2, CCL18, CCL2
46	Cytokine-cytokine receptor interaction20	7.2	TGFB2, TGFB1, CCR7, CCL18, CCL2, IL8
47	MAPK Family Pathway36	7.1	CCL18, CTGF, NTF3, TGFB1, TGFB2, CCL2
48	Antioxidant Action of Vitamin-C36	6.9	CCR7, CTGF, NTF3, TGFB1, TGFB2, CCL18
49	p38 Signaling36	6.9	CCR7, CTGF, NTF3, TGFB1, TGFB2, CCL18
50	Tec Kinases Signaling36	6.7	BDNF, TGFB2, TGFB1, TLR9, NTF3, CTGF

Compounds related to idiopathic interstitial pneumonia according to GeneDecks:

(show top 50)    (show all 162)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.3	IL13, CTGF
2	nicotine32 34 9 9	13.0	CCR7
3	endotoxin32	9.7	THBD, ELANE, TLR9, SCGB1A1, SFTPD
4	pge232	9.7	IL13, EDN1, TGFB2, TGIF1
5	hyaluronic acid32 18	10.7	ELANE, IL13, THBD, THBS1, SCGB1A1
6	heparin32 9 18 9	12.5	TGIF1, ELANE, NTF3, CMA1, SERPINE1
7	doxycycline32 9 9	11.3	ELANE, SCGB1A1, THBS1, IL13, SFTPC, TGIF1
8	sb 20358032 42	10.1	THBS1, CTGF, IL13, VEGFA, EDN1
9	oxygen32 18	9.8	SCGB1A1, SFTPC, SFTPD, BDNF, CTGF, NTF3
10	chloramphenicol32 9 9	10.7	THBD, SFTPC, SERPINE1, SCGB1A1, IL13, NTF3
11	bromodeoxyuridine32	8.7	BDNF, TGFB2, SCGB1A1, IL13, NTF3, KRT14
12	cysteine32	8.6	THBD, TGFB2, THBS1, NTF3, ELANE, KRT14
13	ribonucleic acid32	8.4	THBS1, SFTPC, CCL2, CTGF, NTF3, TGIF1
14	losartan32 34 9 9	11.3	TGFB1, CCL2, THBD, SERPINE1, CTGF, EDN1
15	tarc32	8.2	CCR7, ICAM1, CCL2, CCL18, IL8, IL4R
16	ccl332	8.2	IL13, IL8, CCL2, CCL18, ICAM1, CCR7
17	tgf beta132	8.2	TGIF1, TGFB2, TGFB1, THBS1, CTGF, CCL2
18	polymyxin b32	8.1	THBD, CCL2, IL8, SERPINE1, ICAM1
19	8-isoprostane32	8.0	THBD, IL8, EDN1, SERPINE1, CCL2, ICAM1
20	atorvastatin32 34 9 18 9	11.9	SERPINE1, VEGFA, CCL2, ICAM1, EDN1, THBD
21	vitamin d32	7.9	TGFB1, CCL2, TGIF1, SERPINE1, THBD, THBS1
22	fibrinogen32	7.9	CCL2, THBS1, ELANE, CTGF, ICAM1, SERPINE1
23	triptolide32	7.9	VEGFA, ICAM1, CCR7, CCL2, IL8
24	estrogen32	7.9	SERPINE1, TGIF1, TGFB2, THBS1, THBD, ELANE
25	paraffin32	7.8	NTF3, TGFB1, KRT14, THBD, CCL2, CMA1
26	cytochalasin d32 42	8.8	TGFB1, CCL2, THBS1, ICAM1, IL8, TGIF1
27	calcium32 9 18 9	10.7	CCR7, TGIF1, EDN1, CCL18, CTGF, NTF3
28	retinoic acid32 42 18	9.7	SFTPC, TGFB2, THBD, ELANE, NTF3, CTGF
29	thymidine32 18	8.6	NTF3, CTGF, IL4R, IL13RA1, IL13, BDNF
30	prostacyclin32	7.5	EDN1, CTGF, CCL2, VEGFA, THBD, THBS1
31	creatinine32	7.5	TGIF1, SERPINE1, BDNF, SCGB1A1, CCL2, CTGF
32	gm-csf32	7.4	IL8, VEGFA, TGFB1, ELANE, ICAM1, IL13
33	simvastatin32 34 42 9 18 9	12.4	THBD, ICAM1, IL8, CCL2, VEGFA, SERPINE1
34	ly29400232	7.3	TGFB1, VEGFA, IL13, IL8, CCL2, ICAM1
35	phosphatidylinositol32	7.2	IL13, SCGB1A1, NTF3, BDNF, SFTPD, IL4R
36	rantes32	7.2	IL8, ICAM1, TLR9, CCL18, TGFB1, TGFB2
37	lactate32	7.0	BDNF, ELANE, THBD, TGFB1, ICAM1, IL8
38	curcumin32	7.0	ICAM1, THBD, CTGF, VEGFA, TGFB1, CCL2
39	cyclosporin a32 42	7.8	IL13, IL4R, IL8, CTGF, EDN1, ELANE
40	genistein32 9 18 9	9.7	EDN1, ICAM1, SERPINE1, VEGFA, TGFB2, NTF3
41	vegf32	6.6	SFTPC, SERPINE1, BDNF, IL13RA1, CCL2, CCL18
42	pd 98,05932	6.6	IL13, SERPINE1, BDNF, CCL2, TGFB1, THBS1
43	histamine32 18	7.5	CCL2, IL8, IL4R, IL13, BDNF, ICAM1
44	matrigel32	6.5	VEGFA, SERPINE1, TGFB2, THBS1, BDNF, THBD
45	tyrosine32	6.4	VEGFA, THBD, TGIF1, TGFB2, ICAM1, CCR7
46	nitric oxide32 9 18 9	8.9	THBD, THBS1, TGIF1, TGFB2, TLR9, CCL2
47	actinomycin d32	5.6	ICAM1, NTF3, EDN1, THBD, IL8, SFTPC
48	serine32	5.5	IL8, IL4R, IL13, BDNF, CMA1, SERPINE1
49	dexamethasone32 42 34 9 9	9.2	IL8, THBD, THBS1, CTGF, ICAM1, GREM1
50	cycloheximide32	4.9	CTGF, ICAM1, CCL2, IL8, IL4R, IL13

Cellular components related to idiopathic interstitial pneumonia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	8.9	POSTN, TGFB2, THBS1, CMA1, SERPINE1
2	cell surface	GO:009986	8.3	VEGFA, GREM1, ELANE, THBD, TGFB1, TGFB2
3	platelet alpha granule lumen	GO:031093	8.3	TGFB2, TGFB1, THBS1, VEGFA, SERPINE1
4	extracellular space	GO:005615	4.7	SFTPC, TGFB2, TGFB1, THBS1, THBD, EDN1
5	extracellular region	GO:005576	4.4	CTGF, NTF3, EDN1, ELANE, TLR9, THBS1

Biological processes related to idiopathic interstitial pneumonia according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	10.1	VEGFA, GREM1
2	negative regulation of plasminogen activation	GO:010757	10.1	THBS1, SERPINE1
3	respiratory gaseous exchange	GO:007585	10.1	SFTPC, SFTPD, EDN1
4	negative regulation of release of sequestered calcium ion into cytosol	GO:051280	10.0	TGFB1, TGFB2
5	mechanoreceptor differentiation	GO:042490	10.0	NTF3, BDNF
6	maternal process involved in parturition	GO:060137	10.0	EDN1, CCL2
7	negative regulation of fibrinolysis	GO:051918	10.0	SERPINE1, THBD, THBS1
8	negative regulation of T cell proliferation	GO:042130	10.0	TGFB1, SCGB1A1, SFTPD
9	negative regulation of macrophage cytokine production	GO:010936	9.9	TGFB2, TGFB1
10	negative regulation of blood coagulation	GO:030195	9.8	SERPINE1, EDN1, THBD
11	frontal suture morphogenesis	GO:060364	9.8	TGFB2, TGFB1
12	response to glucose stimulus	GO:009749	9.8	TGFB1, THBS1, CTGF, SFTPC
13	positive regulation of fibroblast migration	GO:010763	9.8	THBS1, TGFB1
14	positive regulation of protein secretion	GO:050714	9.7	TGFB2, TGFB1, IL13
15	positive regulation of JNK cascade	GO:046330	9.7	TLR9, CTGF, CCR7
16	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	ELANE, EDN1, IL13
17	female pregnancy	GO:007565	9.6	TGFB2, TGFB1, THBD, SCGB1A1
18	positive regulation of endothelial cell migration	GO:010595	9.6	VEGFA, EDN1, THBS1
19	inner ear development	GO:048839	9.6	BDNF, TGFB1, TGFB2
20	positive regulation of odontogenesis	GO:042482	9.6	TGFB1, EDN1
21	positive regulation of blood vessel endothelial cell migration	GO:043536	9.5	TGFB1, THBS1, VEGFA
22	response to progesterone stimulus	GO:032570	9.5	CCL2, THBS1, TGFB1, TGFB2
23	positive regulation of neutrophil chemotaxis	GO:090023	9.5	EDN1, CCR7, IL8
24	positive regulation of angiogenesis	GO:045766	9.4	SERPINE1, VEGFA, GREM1, THBS1
25	cell-cell signaling	GO:007267	9.4	TGFB2, EDN1, NTF3, CCL18, IL13, GREM1
26	response to amino acid stimulus	GO:043200	9.4	EDN1, CTGF, ICAM1, CCL2
27	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.4	TGFB1, TLR9, ICAM1, GREM1
28	response to lipopolysaccharide	GO:032496	9.3	THBD, ELANE, EDN1, CCR7, IL13, SFTPC
29	positive regulation of gene expression	GO:010628	9.1	TGFB2, TGFB1, CTGF, VEGFA
30	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, ELANE, EDN1, VEGFA
31	positive regulation of cell migration	GO:030335	9.1	TGFB1, THBS1, EDN1, VEGFA
32	neutrophil chemotaxis	GO:030593	9.0	TGFB2, EDN1, CCL2, IL8
33	transforming growth factor beta receptor signaling pathway	GO:007179	9.0	TGIF1, TGFB2, TGFB1, CCL2, SERPINE1
34	negative regulation of apoptotic process	GO:043066	9.0	SERPINE1, VEGFA, ASCL1, THBS1, TGFB2
35	immune response	GO:006955	8.9	THBS1, CCR7, CCL18, IL8, IL4R, IL13
36	platelet degranulation	GO:002576	8.8	TGFB2, TGFB1, THBS1, VEGFA, SERPINE1
37	cell cycle arrest	GO:007050	8.8	TGFB2, TGFB1, THBS1, IL8
38	cellular response to interleukin-1	GO:071347	8.8	IL8, CCL2, ICAM1, EDN1
39	cellular response to tumor necrosis factor	GO:071356	8.8	IL8, CCL2, ICAM1, EDN1
40	positive regulation of cell division	GO:051781	8.7	VEGFA, TGFB1, TGFB2
41	platelet activation	GO:030168	8.7	SERPINE1, VEGFA, THBS1, TGFB1, TGFB2
42	positive regulation of cell proliferation	GO:008284	8.7	TGFB2, TGFB1, EDN1, CTGF, GREM1, VEGFA
43	cellular response to lipopolysaccharide	GO:071222	8.7	ICAM1, CCL2, IL8, SERPINE1
44	response to hypoxia	GO:001666	8.5	TGFB2, TGFB1, THBS1, EDN1, CCL2, VEGFA
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	TGFB1, TLR9, NTF3, GREM1, ASCL1, VEGFA
46	blood coagulation	GO:007596	8.4	SERPINE1, VEGFA, THBD, THBS1, TGFB1, TGFB2
47	inflammatory response	GO:006954	8.2	TGFB1, TLR9, CCR7, CCL18, CCL2, IL8
48	signal transduction	GO:007165	8.2	NTF3, CCL18, CCL2, IL8, IL4R, IL13RA2
49	angiogenesis	GO:001525	8.1	TGFB2, CTGF, CCL2, IL8, VEGFA, SERPINE1
50	response to drug	GO:042493	8.0	BDNF, TGIF1, TGFB2, TGFB1, THBS1, EDN1

Molecular functions related to idiopathic interstitial pneumonia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor receptor 2 binding	GO:043184	9.4	GREM1, VEGFA
2	fibronectin binding	GO:001968	9.3	VEGFA, CTGF, THBS1
3	chemokine activity	GO:008009	9.1	IL8, CCL2, CCL18
4	cytokine activity	GO:005125	8.7	TGFB2, EDN1, IL13, GREM1, VEGFA
5	heparin binding	GO:008201	8.7	VEGFA, CCL2, CTGF, ELANE, THBS1, POSTN
6	growth factor activity	GO:008083	8.4	TGFB2, TGFB1, NTF3, CTGF, BDNF, VEGFA
7	protein binding	GO:005515	4.9	CCL18, ICAM1, KRT14, ELANE, THBD, THBS1