MCID: IDP011
MIFTS: 45

Idiopathic Interstitial Pneumonia malady

Respiratory diseases category

Summaries for Idiopathic Interstitial Pneumonia

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

MalaCards: Idiopathic Interstitial Pneumonia, also known as diffuse idiopathic pulmonary fibrosis, is related to pneumonia and respiratory failure. An important gene associated with Idiopathic Interstitial Pneumonia is CMA1 (chymase 1, mast cell), and among its related pathways is SIDS Susceptibility Pathways. The compounds scca1 and budesonide have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause, lung and testes, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology:9 A pneumonia located in the lung parenchyma of unknown cause.

Aliases & Classifications for Idiopathic Interstitial Pneumonia

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9Disease Ontology, 59SNOMED-CT, 63UMLS, 28ICD9CM, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

idiopathic interstitial pneumonia 9
diffuse idiopathic pulmonary fibrosis 9
idiopathic fibrosing alveolitis 9


Related Diseases for Idiopathic Interstitial Pneumonia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7SFTPD, IL13
2respiratory failure30.5IL13, CMA1, SFTPD
3dermatomyositis30.3SFTPD, CCR7
4idiopathic pulmonary fibrosis30.2SFTPD, CCR7, IL13
5nonspecific interstitial pneumonia10.6
6desquamative interstitial pneumonia10.4
7connective tissue disease10.3
8interstitial lung disease10.3
9lung cancer10.3
10vascular disease10.3
11usual interstitial pneumonia10.3
12acute interstitial pneumonia10.2
13lymphoid interstitial pneumonia10.2
14cryptogenic organizing pneumonia10.2
15respiratory bronchiolitis-associated interstitial lung disease10.2
16psoriatic arthritis10.2
17bird fancier's lung10.2
18arthritis10.2
19myopathy10.2
20airway-centered interstitial fibrosis10.2
21antisynthetase syndrome10.2
22thromboembolism10.2
23pulmonary function10.2
24venous thromboembolism10.2
25keratoconjunctivitis10.1IL13
26vernal keratoconjunctivitis10.0IL13, CMA1
27mastocytosis10.0CMA1, IL13
28rhinitis10.0IL13, CMA1
29atopy10.0IL13, CMA1
30dermatitis10.0IL13, CMA1
31pulmonary eosinophilia10.0SFTPD, IL13
32atopic dermatitis10.0IL13, CMA1
33sarcoidosis10.0IL13, SFTPD
34pulmonary disease, chronic obstructive10.0SFTPD, IL13
35polymyositis10.0CCR7, SFTPD
36tetanus10.0IL13, CCR7
37systemic scleroderma10.0SFTPD, IL13
38cork-handlers' disease10.0IL13, SFTPD
39skin disease10.0IL13, SFTPD
40allergic asthma10.0SFTPD, CMA1, IL13
41immunodeficiency with hyper igm type 210.0CCR7, SFTPD
42psoriasis10.0IL13, CCR7, CMA1
43tongue squamous cell carcinoma10.0CCR7, ASCL1, CMA1
44rheumatoid arthritis10.0SFTPD, CCR7, IL13
45influenza10.0CCR7, SFTPD
46pulmonary fibrosis9.9SFTPD, CMA1, CCR7, IL13
47asthma9.9IL13, CCR7, CMA1, SFTPD

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to idiopathic interstitial pneumonia

Symptoms for Idiopathic Interstitial Pneumonia

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Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Idiopathic Interstitial Pneumonia

Drug clinical trials:

Search ClinicalTrials for Idiopathic Interstitial Pneumonia

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Search CenterWatch for Idiopathic Interstitial Pneumonia

Genetic Tests for Idiopathic Interstitial Pneumonia

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Anatomical Context for Idiopathic Interstitial Pneumonia

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Idiopathic Interstitial Pneumonia:

34
Lung, Testes, Bone marrow, Bone, Colon

FMA organs/tissues related to Idiopathic Interstitial Pneumonia:

15
The lung parenchyma of unknown cause

Animal Models for Idiopathic Interstitial Pneumonia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Idiopathic Interstitial Pneumonia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3SFTPD, CMA1, CCR7, IL13
2MP:00053888.2GREM1, IL13, ASCL1, SFTPD
3MP:00053878.1SFTPD, CMA1, CCR7, IL13
4MP:00053848.1GREM1, IL13, CCR7, ASCL1

Publications for Idiopathic Interstitial Pneumonia

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53PubMed
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Articles related to Idiopathic Interstitial Pneumonia:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia. (24033388)
2014
2
Limitations to the 6-minute walk test in dermatomyositis with interstitial lung disease in comparison with idiopathic interstitial pneumonia. (23400027)
2013
3
Immunohistochemical detection of virus through its nuclear cytopathic effect in idiopathic interstitial pneumonia other than acute exacerbation. (24270907)
2013
4
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. (23678265)
2013
5
MMP-7 and fcDNA Serum Levels in Early NSCLC and Idiopathic Interstitial Pneumonia: Preliminary Study. (24336111)
2013
6
Chemotherapy for non-small cell lung cancer complicated by idiopathic interstitial pneumonia. (23741246)
2012
7
Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia. (22212399)
2012
8
Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients. (23106582)
2012
9
Significance of connective tissue disease features in idiopathic interstitial pneumonia. (21920896)
2012
10
Prognostic value of immunohistochemical surfactant protein A expression in regenerative/hyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias. (21435274)
2011
11
Postoperative respiratory failure caused by acute exacerbation of idiopathic interstitial pneumonia. (21487668)
2011
12
Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. (21177844)
2011
13
Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization. (20382190)
2010
14
Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia. (20542676)
2010
15
Predictors of survival in idiopathic interstitial pneumonia. (20707290)
2010
16
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. (19690403)
2010
17
Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function. (19654941)
2009
18
Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumonia. (19017875)
2009
19
Systemic sclerosis and idiopathic interstitial pneumonia: histomorphometric differences in lung biopsies. (19618033)
2009
20
TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. (18633634)
2008
21
Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. (18072275)
2008
22
Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia. (18073456)
2008
23
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. (17005585)
2007
24
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. (17334631)
2007
25
Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. (18069415)
2007
26
Pathologic subgroups of nonspecific interstitial pneumonia: differential diagnosis from other idiopathic interstitial pneumonias on high-resolution computed tomography. (16272854)
2005
27
Nonhomogeneous density of CD34 and VCAM-1 alveolar capillaries in major types of idiopathic interstitial pneumonia. (16389728)
2005
28
Semiquantitative 67Ga scintigraphy as an indicator of response to and prognosis after corticosteroid treatment in idiopathic interstitial pneumonia. (16157523)
2005
29
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. (15161635)
2004
30
Angiogenic cytokines in patients with idiopathic interstitial pneumonia. (15223865)
2004
31
A case with acute quadriplegic myopathy following intensive care for idiopathic interstitial pneumonia. (15055401)
2003
32
Idiopathic interstitial pneumonia following stem cell transplantation. (12868990)
2003
33
Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia. (12773329)
2003
34
Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. (12791580)
2003
35
Predicting survival of lung transplantation candidates with idiopathic interstitial pneumonia: does PaO(2) predict survival? (12226013)
2002
36
Steroid treatment based on the findings of transbronchial biopsy in idiopathic interstitial pneumonia. (12449176)
2002
37
Modulation of pulmonary neuroendocrine cells in idiopathic interstitial pneumonia. (12371140)
2002
38
Centrilobular fibrosis: a novel histological pattern of idiopathic interstitial pneumonia. (12440779)
2002
39
Idiopathic interstitial pneumonia: are we missing hypersensitivity pneumonitis? (11814276)
2002
40
The clinical significance of histopathologic subgroups in idiopathic interstitial pneumonia: is surgical lung biopsy essential? (16088685)
2001
41
Nonspecific interstitial pneumonia and the other idiopathic interstitial pneumonias: classification and diagnostic criteria. (10632482)
2000
42
Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (10772122)
2000
43
Surfactant protein A in bronchoalveolar lavage fluid from patients with idiopathic interstitial pneumonia]. (9022314)
1996
44
Lactic dehydrogenase-immunoglobulin G kappa complex in a patient with idiopathic interstitial pneumonia. (8797059)
1996
45
Role of alveolar macrophages in the pathogenesis of idiopathic interstitial pneumonia]. (9216211)
1996
46
Factors affecting prognosis of idiopathic interstitial pneumonia. (8701780)
1996
47
Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic interstitial pneumonia? (8560090)
1995
48
Three cases of idiopathic interstitial pneumonia with bullae seen in schoolteachers. (7485195)
1995
49
A case of severe IgA nephropathy associated with psoriatic arthritis and idiopathic interstitial pneumonia. (8237372)
1993
50
Four cases of lung cancer associated with idiopathic interstitial pneumonia. (2167507)
1990

Variations for Idiopathic Interstitial Pneumonia

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Expression for genes affiliated with Idiopathic Interstitial Pneumonia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for genes affiliated with Idiopathic Interstitial Pneumonia

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Sources:
51PathCards, 39NCBI BioSystems Database
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Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL13, ASCL1

Compounds for genes affiliated with Idiopathic Interstitial Pneumonia

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1scca1469.8IL13, CMA1
2budesonide46 52 1211.7IL13, SFTPD
3nickel46 2510.6IL13, CCR7
4tarc469.6CCR7, IL13
5ccl346 3010.6IL13, CCR7
6ccl446 3010.5CCR7, IL13
7prednisolone46 30 1211.5IL13, SFTPD
8inositol469.4IL13, SFTPD
9allergens469.3IL13, CMA1, SFTPD
10tacrolimus46 52 1211.3IL13, CCR7
11mannose469.3SFTPD, IL13
12histamine46 30 2511.3SFTPD, CMA1, IL13
13endotoxin469.1IL13, SFTPD
14phosphatidylinositol468.9SFTPD, CCR7, IL13
15dexamethasone46 52 30 1211.8GREM1, IL13, SFTPD
16cysteine468.5SFTPD, CMA1, IL13, GREM1
17tyrosine468.2GREM1, IL13, CCR7, ASCL1

GO Terms for genes affiliated with Idiopathic Interstitial Pneumonia

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17Gene Ontology
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Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL13, CCR7
2extracellular spaceGO:0056158.3GREM1, IL13, SFTPD

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.3IL13, CCR7
2positive regulation of angiogenesisGO:0457668.9GREM1, CMA1

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1GREM1, IL13

Products for genes affiliated with Idiopathic Interstitial Pneumonia

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Sources for Idiopathic Interstitial Pneumonia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet