MCID: IDP011
MIFTS: 47

Idiopathic Interstitial Pneumonia malady

Summaries for Idiopathic Interstitial Pneumonia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

MalaCards: Idiopathic Interstitial Pneumonia, also known as diffuse idiopathic pulmonary fibrosis, is related to vascular disease and adenoma. An important gene associated with Idiopathic Interstitial Pneumonia is CMA1 (chymase 1, mast cell), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Degradation of the extracellular matrix. The compounds endotoxin and rantes have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Disease Ontology:8 A pneumonia located in the lung parenchyma of unknown cause.

Aliases & Classifications for Idiopathic Interstitial Pneumonia

Sources:
8Disease Ontology, 57SNOMED-CT, 27ICD9CM, 61UMLS, 35MeSH
See all sources

Aliases & Descriptions:

idiopathic interstitial pneumonia 8
diffuse idiopathic pulmonary fibrosis 8
idiopathic fibrosing alveolitis 8


Related Diseases for Idiopathic Interstitial Pneumonia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease30.4THBS1, THBD, ELANE
2adenoma30.4KRT14, SFTPC, THBS1, ASCL1
3thromboembolism30.2THBD
4arthritis30.2IL13, THBS1, CCR7
5idiopathic pulmonary fibrosis30.2IL13, ELANE, CCR7, SFTPD, SFTPC, SCGB1A1
6nonspecific interstitial pneumonia10.6
7acute interstitial pneumonia10.6
8desquamative interstitial pneumonia10.4
9usual interstitial pneumonia10.3
10alveoli adenoma10.3
11pulmonary systemic sclerosis10.1
12lymphoid interstitial pneumonia10.1
13cryptogenic organizing pneumonia10.1
14respiratory bronchiolitis-associated interstitial lung disease10.1
15psoriatic arthritis10.1
16viral pneumonia10.1
17n syndrome10.1
18antisynthetase syndrome10.1
19idiopathic myopathy10.1
20pulmonary function10.1
21venous thromboembolism10.1
22esophagitis10.0IL13
23peritonitis10.0CMA1
24nephritis10.0SCGB1A1
25bronchiolitis obliterans10.0SCGB1A1
26myocardial infarction10.0POSTN
27pancreatitis10.0ELANE
28hepatitis c10.0TGIF1
29sarcoma10.0IL4R
30gingivitis10.0ELANE
31bronchiolitis10.0IL13, IL4R
32proteinuria10.0SCGB1A1
33malaria10.0TLR9, TGIF1
34rhinitis10.0SCGB1A1, CMA1, IL13
35lupus erythematosus10.0THBD, TLR9
36pheochromocytoma10.0ASCL1, NTF3
37cervical cancer10.0THBS1, KRT14
38bronchopulmonary dysplasia10.0ELANE, SCGB1A1
39respiratory failure10.0SCGB1A1, SFTPD, SFTPC
40diabetic retinopathy10.0THBS1
41mastocytosis10.0CMA1, IL13
42interstitial lung disease10.0SFTPC, SFTPD, IL13RA2
43connective tissue disease10.0TLR9, THBD
44lupus nephritis10.0THBD, TLR9
45medulloblastoma10.0IL13RA2, IL4R, NTF3
46asthma10.0SCGB1A1, IL13
47dermatomyositis10.0SFTPD, THBS1, CCR7
48gastritis10.0SFTPD, TLR9
49large cell carcinoma10.0SFTPC, SFTPD, THBD
50coronary heart disease10.0THBD, THBS1

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to idiopathic interstitial pneumonia

Clinical Features for Idiopathic Interstitial Pneumonia

Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Idiopathic Interstitial Pneumonia

Drug clinical trials:

Search ClinicalTrials for Idiopathic Interstitial Pneumonia

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Search CenterWatch for Idiopathic Interstitial Pneumonia

Genetic Tests for Idiopathic Interstitial Pneumonia

Anatomical Context for Idiopathic Interstitial Pneumonia

Sources:
14FMA
See all sources

FMA organs/tissues related to Idiopathic Interstitial Pneumonia:

14
The lung parenchyma of unknown cause

Animal Models for Idiopathic Interstitial Pneumonia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Idiopathic Interstitial Pneumonia

Sources:
51PubMed
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Articles related to Idiopathic Interstitial Pneumonia:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Viral infections in patients with an acute exacerbation of idiopathic interstitial pneumonia. (24388373)
2014
2
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. (23678265)
2013
3
MMP-7 and fcDNA Serum Levels in Early NSCLC and Idiopathic Interstitial Pneumonia: Preliminary Study. (24336111)
2013
4
Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors. (23659799)
2013
5
Pathologic quantification of connective tissue disease-associated versus idiopathic usual interstitial pneumonia. (23020731)
2012
6
Lung capillary blood volume and membrane diffusion in idiopathic interstitial pneumonia. (22221584)
2012
7
Lymphatic fluctuation in the parenchymal remodeling stage of acute interstitial pneumonia, organizing pneumonia, nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis. (22488224)
2012
8
High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. (23364926)
2012
9
Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization. (20382190)
2010
10
Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia. (20542676)
2010
11
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. (19690403)
2010
12
Venous thromboembolism and risk of idiopathic interstitial pneumonia: a nationwide study. (20167844)
2010
13
Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumonia. (19017875)
2009
14
Nonspecific interstitial pneumonia (NSIP) associated with anti-KS antibody: differentiation from idiopathic NSIP. (19652435)
2009
15
Idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia should stay separate. (18448513)
2008
16
Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. (18072275)
2008
17
Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia. (18073456)
2008
18
Chronic summer-type hypersensitivity pneumonitis initially misdiagnosed as idiopathic interstitial pneumonia. (18451580)
2008
19
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia. (18640828)
2008
20
Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. (18096541)
2008
21
Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of idiopathic nonspecific interstitial pneumonia. (17137778)
2007
22
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. (17005585)
2007
23
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. (17334631)
2007
24
Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: clinical significance of remodeling process. (17294340)
2007
25
High-resolution chest tomography in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: utility and challenges. (17940493)
2007
26
Chronic interstitial pneumonia in silicosis and mix-dust pneumoconiosis: its prevalence and comparison of CT findings with idiopathic pulmonary fibrosis. (17400659)
2007
27
Relationship between histopathological features and the course of idiopathic pulmonary fibrosis/usual interstitial pneumonia. (16769713)
2006
28
Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]. (16502863)
2006
29
Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia. (16493155)
2006
30
Nonhomogeneous density of CD34 and VCAM-1 alveolar capillaries in major types of idiopathic interstitial pneumonia. (16389728)
2005
31
Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (16085216)
2005
32
Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. (15753633)
2005
33
Imaging of the chest: idiopathic interstitial pneumonia. (15564014)
2004
34
Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. (14595745)
2003
35
Fibrotic idiopathic interstitial pneumonia: high-resolution computed tomography considerations. (16088558)
2003
36
Time will tell: predicting survival in idiopathic interstitial pneumonia. (12941653)
2003
37
Octreoscan perspectives in sarcoidosis and idiopathic interstitial pneumonia. (15068232)
2003
38
A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia. (12765340)
2003
39
Centrilobular fibrosis: a novel histological pattern of idiopathic interstitial pneumonia. (12440779)
2002
40
Clinical significance of histological classification of idiopathic interstitial pneumonia. (11866008)
2002
41
The appearance of S-100 protein-positive dendritic cells and the distribution of lymphocyte subsets in idiopathic nonspecific interstitial pneumonia. (12412975)
2002
42
Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP). (11215282)
2001
43
Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. (10988147)
2000
44
Eosinophilic pneumonia-like areas in idiopathic usual interstitial pneumonia. (11144923)
2000
45
Surfactant protein A in bronchoalveolar lavage fluid from patients with idiopathic interstitial pneumonia]. (9022314)
1996
46
Role of alveolar macrophages in the pathogenesis of idiopathic interstitial pneumonia]. (9216211)
1996
47
Clinical characteristics of idiopathic interstitial pneumonia (IIP) with bullae. (8180446)
1994
48
A case of severe IgA nephropathy associated with psoriatic arthritis and idiopathic interstitial pneumonia. (8237372)
1993
49
Four cases of lung cancer associated with idiopathic interstitial pneumonia. (2167507)
1990
50
Idiopathic interstitial pneumonia following bone marrow transplantation: the relationship with total body irradiation. (7033190)
1981

Genetic Variations for Idiopathic Interstitial Pneumonia

Expression for genes affiliated with Idiopathic Interstitial Pneumonia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for genes affiliated with Idiopathic Interstitial Pneumonia

Sources:
53R&D Systems, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN
See all sources

Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL4R, IL13
2
Hide members
10.2ELANE, CMA1
310.0ELANE, SCGB1A1, SFTPD
4
Hide members
10.0IL4R, TLR9, CCR7
59.9IL13RA1, IL4R, IL13RA2
69.8IL13, IL13RA1, IL4R, IL13RA2
7
Hide members
9.7CCR7, CCL18, IL13, IL4R, IL13RA2
8
Hide members
9.4CCL18, NTF3, IL13, IL13RA1, IL4R, IL13RA2
9
Hide members
9.3CCR7, CCL18, NTF3, IL13, IL13RA1, IL4R
10
Hide members
9.3CCR7, CCL18, NTF3, IL13, IL13RA1, IL4R
11
Hide members
9.1IL13RA2, CCR7, CCL18, TLR9, NTF3, IL13

Compounds for genes affiliated with Idiopathic Interstitial Pneumonia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
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Compounds related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.6SCGB1A1, THBD
2rantes4510.6CCR7, IL4R
3sivelestat sodium hydrate4510.5ELANE, SFTPD
4curosurf4510.5SFTPC, ELANE
5sivelestat4510.5ELANE, SFTPD
6glutamate4510.4THBD
7survanta4510.4ELANE, SFTPC
8vitamin a45 11 2412.4KRT14, ELANE
9indoleamine4510.4TLR9, IL13, THBS1
10allergens4510.3CMA1, IL4R, IL13, SFTPD
11kininogen4510.3THBS1
12serine4510.3KRT14, THBS1, CMA1, IL13
13ovomucoid4510.3ELANE
14bromodeoxyuridine4510.3SCGB1A1, NTF3, IL13, KRT14
15ccl345 2911.3IL13, TLR9, CCL18, CCR7
16tarc4510.3CCR7, CCL18, IL13, IL4R
17oxygen45 2411.3SFTPC, SFTPD, SCGB1A1, ELANE
18exotoxin-a4510.2ELANE, IL4R, IL13RA1, IL13
19pentoxifylline45 1111.2ELANE, THBD, IL13
20heparin45 29 11 2413.2NTF3, IL13, CMA1, ELANE, TGIF1
21n-formylmethionyl-leucylphenylalanine4510.2ELANE, THBD, THBS1
22ccl445 2911.1CCR7, CCL18, IL13
23calcitriol45 60 11 2413.1IL13, THBS1, THBD, TGIF1
24hyaluronic acid45 2411.1SCGB1A1, IL13, THBS1, THBD, ELANE
25actinomycin d4510.1THBD, IL4R, IL13, NTF3, SFTPC
26histamine45 29 2412.0SFTPD, NTF3, IL13, IL4R, CMA1, THBD
27paraffin4510.0KRT14, THBD, THBS1, CMA1, NTF3
28paricalcitol45 1111.0THBS1, THBD
29doxycycline45 1111.0TGIF1, SFTPC, SCGB1A1, IL13, THBS1, ELANE
30lactate4510.0TGIF1, ELANE, THBD, IL13, SFTPD
31vitamin d4510.0TGIF1, ELANE, KRT14, THBD, THBS1
32cyclosporin a45 29 6011.9IL13, IL4R, THBS1, THBD, ELANE
33chloramphenicol45 2 1111.9SFTPC, SCGB1A1, NTF3, IL13, THBD, KRT14
34progesterone45 60 29 11 2413.9SCGB1A1, NTF3, THBS1, THBD, KRT14, TGIF1
35phosphatidylinositol459.9CCR7, SFTPD, SCGB1A1, NTF3, IL13, IL4R
36matrigel459.8THBD, THBS1, NTF3, CCR7
37steroid459.8SFTPD, SCGB1A1, NTF3, IL13, IL4R, THBD
38cholesterol45 29 11 2412.8SFTPC, SFTPD, CMA1, THBS1, THBD, KRT14
39threonine459.8SFTPC, NTF3, IL13, THBS1, KRT14, TGIF1
40thymidine45 2410.8SFTPD, NTF3, IL13, IL13RA1, IL4R, THBS1
41alanine459.7CCR7, CCL18, SCGB1A1, IL13, THBS1, THBD
42lipid459.6CCR7, SFTPC, SFTPD, SCGB1A1, THBS1, THBD
43ribonucleic acid459.5TGIF1, THBS1, NTF3, SFTPC
44retinoic acid45 2410.5SFTPC, NTF3, IL13, THBS1, THBD, KRT14
45nitric oxide45 11 2411.5TLR9, SFTPD, SCGB1A1, NTF3, IL13, IL13RA1
46dexamethasone45 50 29 1112.5CCL18, SFTPC, SFTPD, GREM1, IL13, IL4R
47vegf459.4CCL18, SFTPC, NTF3, POSTN, IL13, IL13RA1
48cysteine459.3SFTPC, SFTPD, GREM1, NTF3, IL13, CMA1
49calcium45 50 11 2412.1SCGB1A1, SFTPD, SFTPC, CCL18, CCR7, NTF3
50tyrosine459.0CCR7, TLR9, GREM1, NTF3, IL13, IL13RA1

GO Terms for genes affiliated with Idiopathic Interstitial Pneumonia

Sources:
16Gene Ontology
See all sources

Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.7SCGB1A1, THBS1, ELANE
2extracellular regionGO:0055769.4ELANE, THBS1, CMA1, IL13, NTF3, SFTPD
3extracellular spaceGO:0056158.9THBS1, CCL18, SFTPC, SFTPD, SCGB1A1, GREM1

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.2THBD, THBS1
2positive regulation of macrophage activationGO:04303210.2IL13, IL4R, THBS1
3positive regulation of receptor internalizationGO:00209210.2NTF3, GREM1
4positive regulation of angiogenesisGO:04576610.0THBS1, CMA1, GREM1
5response to lipopolysaccharideGO:03249610.0ELANE, IL13, SCGB1A1, SFTPC, CCR7
6cell-cell signalingGO:00726710.0CCL18, GREM1, NTF3, IL13
7immune responseGO:0069559.8CCR7, CCL18, IL13, IL4R, THBS1
8extracellular matrix organizationGO:0301989.7POSTN, CMA1, THBS1, ELANE
9inflammatory responseGO:0069549.6IL13, TLR9, CCL18, CCR7
10signal transductionGO:0071659.6CCL18, SCGB1A1, NTF3, IL13, IL4R, IL13RA2

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.2TGIF1, SFTPC, SFTPD, SCGB1A1, GREM1, IL13

Products for genes affiliated with Idiopathic Interstitial Pneumonia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Idiopathic Interstitial Pneumonia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet