MCID: IDP011
MIFTS: 60

Idiopathic Interstitial Pneumonia

Categories: Respiratory diseases

Aliases & Classifications for Idiopathic Interstitial Pneumonia

MalaCards integrated aliases for Idiopathic Interstitial Pneumonia:

Name: Idiopathic Interstitial Pneumonia 12 14
Idiopathic Interstitial Pneumonias 36 69
Pulmonary Fibrosis 41 69
Idiopathic Interstitial Pneumonia, Not Otherwise Specified 69
Diffuse Idiopathic Pulmonary Fibrosis 12
Idiopathic Fibrosing Alveolitis 12
Hamman-Rich Syndrome 69
Ipf 12

Classifications:



Summaries for Idiopathic Interstitial Pneumonia

Disease Ontology : 12 A pneumonia located in the lung parenchyma of unknown cause.

MalaCards based summary : Idiopathic Interstitial Pneumonia, also known as idiopathic interstitial pneumonias, is related to nonspecific interstitial pneumonia and acute interstitial pneumonia, and has symptoms including snoring, hemoptysis and coughing. An important gene associated with Idiopathic Interstitial Pneumonia is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Bosentan and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause, lung and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 72 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

Related Diseases for Idiopathic Interstitial Pneumonia

Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 nonspecific interstitial pneumonia 33.5 CCL2 IFNG IL13 SFTPC
2 acute interstitial pneumonia 32.3 SFTPA1 SFTPA2 SFTPD
3 interstitial lung disease 31.1 CCL2 CXCL8 EDN1 IFNG IL4 MUC5B
4 pneumonia 30.3 CCL2 CXCL8 ELANE IL13 MUC5B SFTPC
5 allergic hypersensitivity disease 30.3 IFNG IL13 IL4 TLR9
6 bronchiolitis 29.6 CXCL8 IFNG IL13 IL4 MUC5B TLR9
7 pulmonary fibrosis, idiopathic 29.5 CCL2 CTGF CXCL8 EDN1 ELANE IFNG
8 respiratory failure 29.5 CXCL8 EDN1 ELANE SFTPC SFTPD
9 vascular disease 29.4 CCL2 EDN1 SERPINE1 VEGFA
10 pulmonary hypertension 29.4 EDN1 ELANE SERPINE1 SFTPC VEGFA
11 pulmonary fibrosis 28.5 CCL2 CTGF EDN1 IL13 MUC5B SFTPA1
12 lung disease 27.9 CCL2 CXCL8 EDN1 ELANE IL13 MUC5B
13 desquamative interstitial pneumonia 11.4
14 airway-centered interstitial fibrosis 11.2
15 lymphoid interstitial pneumonia 11.1
16 cryptogenic organizing pneumonia 11.1
17 mycoplasmal pneumonia 10.6 IFNG IL4
18 strongyloidiasis 10.5 IFNG IL13 TGFB1
19 penicillin allergy 10.5 IFNG IL13 IL4
20 respiratory distress syndrome in premature infants 10.5 SFTPA1 SFTPC
21 urinary schistosomiasis 10.5 IFNG IL13 IL4
22 hyperlucent lung 10.5 IFNG IL4
23 parasitic helminthiasis infectious disease 10.4 IL13 IL4 TLR9
24 coccidiosis 10.4 IFNG IL4 TLR9
25 cryptococcosis 10.4 IFNG IL4 TLR9
26 clonorchiasis 10.4 CXCL8 IFNG TGFB1
27 food allergy 10.4 IFNG IL13 IL4
28 ocular cicatricial pemphigoid 10.4 CTGF IL4 TGFB1
29 opportunistic mycosis 10.4 IFNG IL4 TLR9
30 middle ear disease 10.4 CXCL8 MUC5B TLR9
31 allergic bronchopulmonary aspergillosis 10.4 IL4 SFTPA2 SFTPD
32 ige responsiveness, atopic 10.4 IFNG IL13 IL4
33 esophagitis 10.4 CXCL8 IL13 TGFB1
34 malignant renovascular hypertension 10.4 EDN1 SERPINE1
35 pulmonary alveolar proteinosis 10.4 CCL2 SFTPC SFTPD
36 brucellosis 10.4 CXCL8 IFNG IL4
37 primary bacterial infectious disease 10.3 IFNG IL4 TLR9
38 extrinsic cardiomyopathy 10.3 CCL2 IL4 TLR9
39 nephrosclerosis 10.3 CCL2 CTGF TGFB1
40 sezary's disease 10.3 IFNG IL4 TLR9
41 schistosomiasis 10.3 IFNG IL13 IL4
42 toxoplasmosis 10.3 IFNG IL4 TLR9
43 neuritis 10.3 CCL2 IFNG IL4
44 cutaneous leishmaniasis 10.3 IFNG IL13 IL4 TLR9
45 hypersensitivity reaction disease 10.3 IFNG IL13 IL4 TLR9
46 immune system disease 10.3 IFNG IL13 IL4 TLR9
47 vitreoretinopathy, neovascular inflammatory 10.3 CCL2 CTGF TGFB1
48 urinary tract obstruction 10.3 CCL2 CTGF TGFB1
49 pleural tuberculosis 10.3 CCL2 CXCL8 IFNG
50 eales disease 10.3 IFNG IL4 VEGFA

Comorbidity relations with Idiopathic Interstitial Pneumonia via Phenotypic Disease Network (PDN): (show all 22)


Acute Cystitis Aortic Valve Disease 1
Bronchiectasis Bronchitis
Bronchopneumonia Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatoid Arthritis Rheumatoid Lung Disease

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to Idiopathic Interstitial Pneumonia

Symptoms & Phenotypes for Idiopathic Interstitial Pneumonia

UMLS symptoms related to Idiopathic Interstitial Pneumonia:


snoring, hemoptysis, coughing

MGI Mouse Phenotypes related to Idiopathic Interstitial Pneumonia:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CXCR4 SFTPA1 IL4 ICAM1 EDN1 IFNG
2 growth/size/body region MP:0005378 10.3 CXCR4 IL4 SFTPC ICAM1 IFNG EDN1
3 cellular MP:0005384 10.26 GREM1 CXCR4 ICAM1 IL4 IFNG MUC5B
4 hematopoietic system MP:0005397 10.25 SFTPA1 CXCR4 IL4 ICAM1 IFNG MUC5B
5 mortality/aging MP:0010768 10.25 IL4 ICAM1 SFTPC EDN1 IFNG MUC5B
6 immune system MP:0005387 10.24 CXCR4 SFTPA1 IL4 ICAM1 SFTPC IFNG
7 digestive/alimentary MP:0005381 10.19 CXCR4 IL4 ICAM1 IFNG EDN1 CTGF
8 endocrine/exocrine gland MP:0005379 10.13 CXCR4 ICAM1 IL4 IFNG EDN1 CTGF
9 craniofacial MP:0005382 10.05 CXCR4 IL4 IFNG EDN1 CTGF VEGFA
10 neoplasm MP:0002006 9.86 CXCR4 SFTPC ICAM1 IFNG ELANE SERPINE1
11 renal/urinary system MP:0005367 9.81 CXCR4 IL4 IFNG EDN1 SERPINE1 GREM1
12 respiratory system MP:0005388 9.77 SFTPC IFNG MUC5B CTGF IL13 SERPINE1
13 skeleton MP:0005390 9.28 GREM1 CXCR4 IL4 IFNG EDN1 CTGF

Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

Drugs for Idiopathic Interstitial Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 211)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2 147536-97-8 104865
2
Pirfenidone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53179-13-8 40632
3
Nintedanib Approved Phase 4,Phase 3,Phase 2,Phase 1 656247-17-5 56843413
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 77-92-9 311
5 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2,Phase 3
6 Phosphodiesterase Inhibitors Phase 4,Phase 2,Phase 3
7 Sildenafil Citrate Phase 4,Phase 2,Phase 3 171599-83-0
8 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
9 Antihypertensive Agents Phase 4,Phase 3,Phase 2
10 Endothelin Receptor Antagonists Phase 4,Phase 3,Phase 2
11 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
12 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
15 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Citrate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
18
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
19
Treprostinil Approved, Investigational Phase 3,Phase 2 81846-19-7 6918140 54786
20
Iloprost Approved, Investigational Phase 2, Phase 3 78919-13-8 6443959
21
Acetylcysteine Approved, Investigational Phase 3,Phase 2,Phase 1 616-91-1 12035
22
Azathioprine Approved Phase 3,Phase 1,Phase 2 446-86-6 2265
23
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
24
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
25
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 50-24-8 5755
27
Angiotensin II Approved, Investigational Phase 2, Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
28
Losartan Approved Phase 2, Phase 3 114798-26-4 3961
29
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
30
Mycophenolic acid Approved Phase 3 24280-93-1 446541
31
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
32
Lenograstim Approved, Investigational Phase 3 135968-09-1
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
34
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
35
Sulfamethoxazole Approved Phase 3 723-46-6 5329
36
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
37
Warfarin Approved Phase 3 81-81-2 54678486 6691
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
40 Anti-Bacterial Agents Phase 3,Phase 2
41 Anti-Infective Agents Phase 3,Phase 2,Phase 1
42 Platelet Aggregation Inhibitors Phase 2, Phase 3
43 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
44 Antiviral Agents Phase 3,Phase 2,Phase 1
45 Antidotes Phase 3,Phase 2,Phase 1
46 Antioxidants Phase 3,Phase 2,Phase 1
47 Expectorants Phase 3,Phase 2,Phase 1
48 N-monoacetylcystine Phase 3,Phase 2,Phase 1
49 Protective Agents Phase 3,Phase 2,Phase 1
50 Respiratory System Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 293)

# Name Status NCT ID Phase Drugs
1 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With Sildenafil Unknown status NCT00625079 Phase 4 sildenafil;sildenafil
2 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan Unknown status NCT00625469 Phase 4 bosentan
3 Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients Unknown status NCT01382368 Phase 4 Sildenafil
4 Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study Unknown status NCT00637065 Phase 4 Bosentan;Placebo
5 Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT02598193 Phase 4 Nintedanib;Pirfenidone
6 Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPF Completed NCT02579603 Phase 4 Nintedanib;Pirfenidone
7 A Study to Compare the Amount of Nintedanib and Pirfenidone in the Blood When Nintedanib and Pirfenidone Are Given Separately or in Combination Completed NCT02606877 Phase 4 nintedanib;pirfenidone
8 Effect of Nintedanib on Biomarkers of Extracellular Matrix Turnover in Patients With Idiopathic Pulmonary Fibrosis and Limited Forced Vital Capacity Impairment Active, not recruiting NCT02788474 Phase 4 nintedanib;placebo
9 Pirfenidone in Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis Not yet recruiting NCT02821689 Phase 4 Pirfenidone
10 68Ga-DOTA-NOC PET/CT in Patients With Idiopathic Pulmonary Fibrosis Terminated NCT01321996 Phase 4
11 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
12 Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial Hypertension Unknown status NCT00705133 Phase 3 treprostinil
13 Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary Fibrosis Unknown status NCT00439543 Phase 2, Phase 3 Iloprost inhalation
14 Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide Completed NCT00600028 Phase 3 Thalidomide;Placebo
15 Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443 Completed NCT00631475 Phase 3 Bosentan
16 Efficacy and Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT01366209 Phase 3 Pirfenidone;Placebo
17 Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00071461 Phase 2, Phase 3 bosentan;Placebo
18 Three-Arm Study of the Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00287716 Phase 3 Pirfenidone;Placebo
19 Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis Completed NCT00287729 Phase 3 Pirfenidone;Placebo
20 Targeting Vascular Reactivity in Idiopathic Pulmonary Fibrosis Completed NCT00981747 Phase 2, Phase 3 Sildenafil;Losartan;Sildenafil and Losartan;Placebo pill
21 Gleevec Idiopathic Pulmonary Fibrosis (IPF) Study Completed NCT00131274 Phase 2, Phase 3 Imatinib Mesylate (Gleevec)
22 Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis Completed NCT00517933 Phase 3 Sildenafil Citrate
23 Open-Label Study of the Long Term Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00662038 Phase 3 pirfenidone
24 A Study of the Safety and Efficacy Interferon-Gamma 1b in Patients With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00047645 Phase 3 Interferon-gamma 1b
25 Study of the Effects of High-dose N-acetylcysteine (NAC) in Idiopathic Pulmonary Fibrosis (IPF) Completed NCT00639496 Phase 3 n-acetylcysteine;placebo
26 Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients Completed NCT01335464 Phase 3 placebo;BIBF 1120
27 Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients II Completed NCT01335477 Phase 3 placebo;BIBF 1120
28 BUILD 3: Bosentan Use in Interstitial Lung Disease Completed NCT00391443 Phase 3 Bosentan;Placebo
29 Phase III Study on Rotavirus Vaccine to Evaluate Lot-to-lot Consistency and Interference With Routine UIP Immunization Completed NCT02584816 Phase 3
30 Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF Completed NCT00650091 Phase 3 N-acetylcysteine (NAC);Placebo
31 A Study of Mycophenolate Mofetil (CellCept) in Lung Transplant Recipients Completed NCT01014442 Phase 3 mycophenolate mofetil
32 Rituximab in Rheumatoid Arthritis Lung Disease Completed NCT00578565 Phase 3 Rituximab
33 High Dose Cyclophosphamide for Treatment of Scleroderma Completed NCT00501995 Phase 3 IV Cyclophosphamide
34 EZ-2053 in the Prophylaxis of Acute Pulmonary Allograft Rejection Completed NCT00105183 Phase 3
35 Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma Completed NCT00070590 Phase 2, Phase 3 Bosentan
36 Clinical Study of ART-123 for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis Recruiting NCT02739165 Phase 3 ART-123;Placebo
37 Open-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis (IPF). Recruiting NCT03208933 Phase 3 Pirfenidone
38 Cyclophosphamide for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Recruiting NCT02460588 Phase 3 Cyclophosphamide;Placebo;Corticosteroid (prednisolone)
39 Nebulized Fentanyl in Patients With Mild to Moderate Idiopathic Pulmonary Fibrosis and Chronic Dyspnea Recruiting NCT03018756 Phase 3 Fentanyl Citrate;Placebo
40 CleanUP IPF for the Pulmonary Trials Cooperative Recruiting NCT02759120 Phase 3 Antimicrobial therapy: Co-trimoxazole or Doxycycline
41 Efficacy and Safety of Nintedanib When Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment Active, not recruiting NCT02802345 Phase 3 Nintedanib;Placebo;Sildenafil
42 Extension Trial of the Long Term Safety of BIBF 1120 in Patients With Idiopathic Pulmonary Fibrosis Active, not recruiting NCT01619085 Phase 3 BIBF 1120
43 A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis Active, not recruiting NCT02597933 Phase 3 Nintedanib;Placebo
44 Pirfenidone as Treatment of Skin Fibrosis in Systemic Sclerosis Not yet recruiting NCT03068234 Phase 2, Phase 3 Pirfenidone;Placebo oral capsule;Steroids
45 Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole Terminated NCT01777737 Phase 3 Cotrimoxazole;Placebo
46 ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis Terminated NCT00879229 Phase 3 Ambrisentan;Placebo
47 AntiCoagulant Effectiveness in Idiopathic Pulmonary Fibrosis Terminated NCT00957242 Phase 3 warfarin;placebo
48 Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF) Terminated NCT01979952 Phase 3 Matching Placebo;Nintedanib
49 (ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF Terminated NCT00768300 Phase 3 Ambrisentan;Placebo
50 The INSPIRE Trial: A Study of Interferon Gamma-1b for Idiopathic Pulmonary Fibrosis (IPF) Terminated NCT00075998 Phase 3 Interferon gamma-1b ("Actimmune")

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: pulmonary fibrosis

Genetic Tests for Idiopathic Interstitial Pneumonia

Anatomical Context for Idiopathic Interstitial Pneumonia

The Foundational Model of Anatomy Ontology organs/tissues related to Idiopathic Interstitial Pneumonia:

18
The Lung Parenchyma Of Unknown Cause

MalaCards organs/tissues related to Idiopathic Interstitial Pneumonia:

38
Lung, Testes, Heart, Bone Marrow, Bone, Skin, Skeletal Muscle

Publications for Idiopathic Interstitial Pneumonia

Articles related to Idiopathic Interstitial Pneumonia:

(show top 50) (show all 148)
# Title Authors Year
1
Baseline serum syndecan-4 predicts prognosis after the onset of acute exacerbation of idiopathic interstitial pneumonia. ( 28467516 )
2017
2
A pilot trial of nivolumab treatment for advanced non-small cell lung cancer patients with mild idiopathic interstitial pneumonia. ( 28838377 )
2017
3
Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-Melanoma Differentiation-Associated Gene-5 Antibody by Intensive Immunosuppressive Therapy. ( 29269659 )
2017
4
Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia. ( 29229096 )
2017
5
Occupational and Environmental Risk Factors for Chronic Fibrosing idiopathic Interstitial Pneumonia in South Korea. ( 28938261 )
2017
6
Respiratory bronchiolitis-associated interstitial lung disease - an unexpected form of idiopathic interstitial pneumonia in a young male. ( 28523329 )
2017
7
Idiopathic Interstitial Pneumonia Associated With Autoantibodies: A Large Case Series Followed Over 1 Year. ( 28300570 )
2017
8
Volume doubling time of lung cancer detected in idiopathic interstitial pneumonia: comparison with that in chronic obstructive pulmonary disease. ( 29038933 )
2017
9
Impact of lymphocyte differential counta88>a8815% in BALF on the mortality of patients with acute exacerbation of chronic fibrosing idiopathic interstitial pneumonia. ( 28427425 )
2017
10
Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. ( 26792595 )
2016
11
Heterogeneity of incidence and outcome of acute exacerbation in idiopathic interstitial pneumonia. ( 27460223 )
2016
12
A Multidisciplinary Evaluation Helps Identify the Antisynthetase Syndrome in Patients Presenting as Idiopathic Interstitial Pneumonia. ( 26932342 )
2016
13
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. ( 27266705 )
2016
14
Idiopathic interstitial pneumonia-associated pulmonary hypertension: A target for therapy? ( 27884593 )
2016
15
Incidence and prevalence of idiopathic interstitial pneumonia and idiopathic pulmonary fibrosis in Korea. ( 27287654 )
2016
16
Clinical Implication of Proteinase-3-antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias. ( 26873743 )
2016
17
Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia. ( 28079842 )
2016
18
Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis. ( 27564852 )
2016
19
Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias. ( 26699835 )
2016
20
Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer. ( 26792177 )
2016
21
The pathological features of idiopathic interstitial pneumonia-associated pulmonary adenocarcinomas. ( 27757985 )
2016
22
Identification of Clinical Phenotypes in Idiopathic Interstitial Pneumonia with Pulmonary Emphysema. ( 27301501 )
2016
23
Postoperative pyothorax a risk factor for acute exacerbation of idiopathic interstitial pneumonia following lung cancer resection. ( 27277761 )
2016
24
Idiopathic pleuroparenchymal fibroelastosis - A rare idiopathic interstitial pneumonia. ( 27141432 )
2016
25
Idiopathic pleuroparenchymal fibroelastosis, a new idiopathic interstitial pneumonia: A case report. ( 26810762 )
2016
26
Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia. ( 26416262 )
2015
27
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. ( 25682542 )
2015
28
Symptom-based management of the idiopathic interstitial pneumonia. ( 26450007 )
2015
29
Smoking-related idiopathic interstitial pneumonia: A review. ( 26138798 )
2015
30
The correlation of symptoms, pulmonary function tests and exercise testing with high-resolution computed tomography in patients with idiopathic interstitial pneumonia in a tertiary care hospital in South India. ( 26664164 )
2015
31
Newly Detected Pulmonary Nontuberculous Mycobacterial Infection and Peripheral Lung Cancers in Patients During Follow-Up of Idiopathic Interstitial Pneumonia: Comparison of CT Findings. ( 25837763 )
2015
32
Idiopathic interstitial pneumonia in the ICU: an observational cohort. ( 26603794 )
2015
33
Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs. ( 26539479 )
2015
34
SFTPA2 Mutations in Familial and Sporadic Idiopathic Interstitial Pneumonia. ( 26568241 )
2015
35
Pulmonary Resection for Lung Cancer in Patients With Idiopathic Interstitial Pneumonia. ( 26116477 )
2015
36
Role of I+1 and I+2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts. ( 26006016 )
2015
37
Scoring of the radiological picture of idiopathic interstitial pneumonia: a study to verify the reliability of the method. ( 26600944 )
2015
38
Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. ( 26231557 )
2015
39
Evolving Early Lung Cancers Detected During Follow-Up of Idiopathic Interstitial Pneumonia: Serial CT Features. ( 26001227 )
2015
40
Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients. ( 24613046 )
2014
41
Viral infections in patients with an acute exacerbation of idiopathic interstitial pneumonia. ( 24388373 )
2014
42
Smoking-related idiopathic interstitial pneumonia. ( 25063244 )
2014
43
Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia. ( 24033388 )
2014
44
Connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonia: similarity and difference. ( 24480141 )
2014
45
Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia. ( 24937643 )
2014
46
Low-normal lung volume correlates with pulmonary hypertension in fibrotic idiopathic interstitial pneumonia: computer-aided 3D quantitative analysis of chest CT. ( 25055292 )
2014
47
Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia - short term evaluation of safety and tolerability. ( 24886036 )
2014
48
The pandemic influenza A (H1N1) 2009 vaccine does not increase the mortality rate of idiopathic interstitial pneumonia: a matched case-control study. ( 24586445 )
2014
49
Immunohistochemical detection of virus through its nuclear cytopathic effect in idiopathic interstitial pneumonia other than acute exacerbation. ( 24270907 )
2013
50
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. ( 23678265 )
2013

Variations for Idiopathic Interstitial Pneumonia

Expression for Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for Idiopathic Interstitial Pneumonia

Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CCL2 CXCL8 CXCR4 EDN1 IFNG IL13
2
Show member pathways
13.55 CCL2 CTGF CXCL8 CXCR4 ICAM1 IFNG
3
Show member pathways
13.44 CCL2 CTGF CXCL8 CXCR4 IL13 IL4
4
Show member pathways
13.39 CCL2 CXCL8 ICAM1 IFNG IL13 IL4
5
Show member pathways
13.32 CCL2 CTGF CXCL8 CXCR4 IL13 IL4
6
Show member pathways
13 CCL2 CXCL8 EDN1 MUC5B SERPINE1 TLR9
7 12.84 CXCL8 CXCR4 IFNG IL13 IL4 TGFB1
8
Show member pathways
12.8 CXCL8 CXCR4 ICAM1 IFNG IL13 IL4
9
Show member pathways
12.79 CCL2 CXCL8 ICAM1 IFNG IL13 IL4
10 12.59 CCL2 CXCR4 IFNG IL4 TLR9
11
Show member pathways
12.55 CCL2 CXCL8 IFNG SERPINE1 TGFB1 TLR9
12
Show member pathways
12.35 CCL2 ICAM1 IFNG IL4 SERPINE1
13
Show member pathways
12.33 CCL2 CXCL8 IFNG IL13 IL4 MUC5B
14 12.27 CTGF GREM1 SERPINE1 TGFB1
15 12.21 IFNG TGFB1 TLR9 VEGFA
16
Show member pathways
12.17 CXCL8 IFNG IL13 IL4
17
Show member pathways
12.13 CXCL8 IFNG IL4 SFTPA1 SFTPD TLR9
18 12.09 CCL2 ICAM1 SERPINE1 TLR9
19 12.09 CCL2 EDN1 ICAM1 IFNG VEGFA
20 11.97 CXCL8 IFNG SERPINE1 TGFB1
21 11.96 CCL2 CXCL8 ICAM1 IFNG IL4 TGFB1
22 11.94 EDN1 IFNG SERPINE1 VEGFA
23
Show member pathways
11.91 SFTPA1 SFTPA2 SFTPC SFTPD
24
Show member pathways
11.88 IFNG IL4 TGFB1 TLR9
25 11.86 CCL2 CXCL8 ICAM1 IL13 IL4 TGFB1
26 11.84 CCL2 GREM1 TGFB1
27 11.81 CXCL8 ICAM1 IFNG IL13 IL4
28 11.8 IFNG IL13 IL4
29
Show member pathways
11.77 CXCL8 IFNG IL4
30 11.77 CXCL8 SFTPA1 SFTPA2
31 11.76 IFNG TGFB1 TLR9
32 11.75 CCL2 CXCL8 ICAM1 IFNG TGFB1 VEGFA
33 11.73 ICAM1 IL4 TGFB1 TLR9
34 11.71 CXCR4 EDN1 SERPINE1 VEGFA
35
Show member pathways
11.69 CXCL8 ICAM1 IFNG VEGFA
36 11.65 IFNG SERPINE1 TGFB1
37 11.58 CXCL8 TGFB1 VEGFA
38 11.55 CTGF ELANE ICAM1
39
Show member pathways
11.53 SFTPA1 SFTPA2 SFTPD
40 11.52 IFNG IL13 IL4
41 11.5 CXCL8 ICAM1 IFNG
42 11.5 CCL2 CXCL8 EDN1 ICAM1 SERPINE1 TGFB1
43
Show member pathways
11.47 SFTPA1 SFTPA2 SFTPC SFTPD
44 11.46 CCL2 CXCL8 ICAM1 IL13 IL4
45 11.41 EDN1 SERPINE1 VEGFA
46 11.38 ICAM1 IFNG TLR9
47 11.34 IFNG IL13 IL4
48 11.32 CCL2 CXCL8 ICAM1 IFNG TGFB1 TLR9
49 11.29 IFNG IL13 IL4 TGFB1
50 11.27 IFNG IL13 TGFB1

GO Terms for Idiopathic Interstitial Pneumonia

Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CCL2 CTGF CXCL8 EDN1 ELANE GREM1
2 proteinaceous extracellular matrix GO:0005578 9.87 CTGF SFTPA1 SFTPA2 SFTPD TGFB1 TLR9
3 cell surface GO:0009986 9.85 CXCR4 ELANE GREM1 ICAM1 TGFB1 VEGFA
4 secretory granule GO:0030141 9.61 ELANE TGFB1 VEGFA
5 extracellular space GO:0005615 9.6 CCL2 CTGF CXCL8 EDN1 ELANE GREM1
6 platelet alpha granule lumen GO:0031093 9.58 SERPINE1 TGFB1 VEGFA
7 clathrin-coated endocytic vesicle GO:0045334 9.56 SFTPA1 SFTPA2 SFTPC SFTPD
8 lamellar body GO:0042599 9.46 SFTPA1 SFTPA2 SFTPC SFTPD

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.98 SFTPA1 SFTPA2 SFTPC SFTPD
2 negative regulation of gene expression GO:0010629 9.97 CTGF IFNG TGFB1 VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 CCL2 CTGF ICAM1 TGFB1
4 response to lipopolysaccharide GO:0032496 9.95 EDN1 ELANE ICAM1 IL13
5 inflammatory response GO:0006954 9.95 CCL2 CXCL8 CXCR4 IL13 TGFB1 TLR9
6 positive regulation of protein phosphorylation GO:0001934 9.92 CTGF IFNG TGFB1 VEGFA
7 chemotaxis GO:0006935 9.92 CCL2 CXCL8 CXCR4 IL4
8 cellular response to interferon-gamma GO:0071346 9.88 CCL2 EDN1 ICAM1
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 GREM1 ICAM1 TGFB1 TLR9
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 ICAM1 TGFB1 VEGFA
11 positive regulation of angiogenesis GO:0045766 9.87 CXCL8 GREM1 SERPINE1 VEGFA
12 movement of cell or subcellular component GO:0006928 9.86 CXCL8 IFNG IL13
13 cellular response to tumor necrosis factor GO:0071356 9.86 CCL2 CXCL8 EDN1 ICAM1
14 chemokine-mediated signaling pathway GO:0070098 9.85 CCL2 CXCL8 CXCR4
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL13 VEGFA
16 cellular response to lipopolysaccharide GO:0071222 9.85 CCL2 CXCL8 ICAM1 SERPINE1
17 neutrophil chemotaxis GO:0030593 9.84 CCL2 CXCL8 EDN1
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 EDN1 ELANE IL13
19 calcium-mediated signaling GO:0019722 9.81 CXCL8 CXCR4 EDN1
20 response to hypoxia GO:0001666 9.8 CXCR4 EDN1 ICAM1 TGFB1 VEGFA
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 EDN1 ICAM1 IFNG
22 positive regulation of B cell proliferation GO:0030890 9.77 IL13 IL4 TLR9
23 cellular response to interleukin-1 GO:0071347 9.73 CCL2 CXCL8 EDN1 ICAM1
24 angiogenesis GO:0001525 9.73 CCL2 CTGF CXCL8 GREM1 SERPINE1 VEGFA
25 macrophage chemotaxis GO:0048246 9.7 CCL2 SFTPD
26 positive regulation of cardiac muscle cell differentiation GO:2000727 9.7 GREM1 TGFB1
27 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 TLR9
28 response to amino acid GO:0043200 9.7 CTGF EDN1 ICAM1
29 PERK-mediated unfolded protein response GO:0036499 9.69 CCL2 CXCL8
30 negative regulation of interleukin-17 production GO:0032700 9.68 IFNG TGFB1
31 positive regulation of protein complex assembly GO:0031334 9.67 IFNG TGFB1 VEGFA
32 positive regulation of MAP kinase activity GO:0043406 9.67 EDN1 ELANE TGFB1 VEGFA
33 surfactant homeostasis GO:0043129 9.66 SFTPD VEGFA
34 acute inflammatory response to antigenic stimulus GO:0002438 9.66 ELANE ICAM1
35 positive regulation of immunoglobulin production GO:0002639 9.65 IL13 TLR9
36 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.63 GREM1 TGFB1 VEGFA
37 toll-like receptor signaling pathway GO:0002224 9.62 SFTPA1 SFTPA2 SFTPD TLR9
38 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.61 GREM1 VEGFA
39 response to salt GO:1902074 9.61 EDN1 TGFB1
40 positive regulation of odontogenesis GO:0042482 9.58 EDN1 TGFB1
41 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL13 IL4
42 negative regulation of endothelial cell apoptotic process GO:2000352 9.46 ICAM1 IL13 IL4 SERPINE1
43 respiratory gaseous exchange GO:0007585 9.35 EDN1 SFTPA1 SFTPA2 SFTPC SFTPD
44 regulation of receptor activity GO:0010469 9.32 CCL2 CTGF CXCL8 EDN1 IFNG IL13
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 EDN1 GREM1 IL4 SERPINE1 TGFB1 TLR9
46 immune response GO:0006955 10.09 CCL2 CXCL8 IFNG IL13 IL4
47 positive regulation of gene expression GO:0010628 10.03 CTGF IFNG TGFB1 TLR9 VEGFA
48 positive regulation of cell proliferation GO:0008284 10.01 CTGF EDN1 GREM1 IFNG TGFB1 VEGFA

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 CCL2 CTGF CXCL8 CXCR4 EDN1 ELANE
2 growth factor activity GO:0008083 9.46 CTGF IL4 TGFB1 VEGFA
3 cytokine activity GO:0005125 9.28 CCL2 CXCL8 EDN1 GREM1 IFNG IL13
4 vascular endothelial growth factor receptor 2 binding GO:0043184 9.26 GREM1 VEGFA

Sources for Idiopathic Interstitial Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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