MCID: IDP011
MIFTS: 46

Idiopathic Interstitial Pneumonia malady

Respiratory diseases category
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Summaries for Idiopathic Interstitial Pneumonia

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Wikipedia:65 Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia are a class of diffuse lung... more...

MalaCards based summary: Idiopathic Interstitial Pneumonia, also known as idiopathic fibrosing alveolitis, is related to pneumonia and respiratory failure. An important gene associated with Idiopathic Interstitial Pneumonia is CMA1 (chymase 1, mast cell), and among its related pathways is SIDS Susceptibility Pathways. The compounds scca1 and budesonide have been mentioned in the context of this disorder. Affiliated tissues include the lung parenchyma of unknown cause, lung and testes, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology:8 A pneumonia located in the lung parenchyma of unknown cause.

Aliases & Classifications for Idiopathic Interstitial Pneumonia

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Idiopathic Interstitial Pneumonia, Aliases & Descriptions:

Name: Idiopathic Interstitial Pneumonia 8 62
Idiopathic Fibrosing Alveolitis 8 62
 
Diffuse Idiopathic Pulmonary Fibrosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Related Diseases for Idiopathic Interstitial Pneumonia

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Diseases related to Idiopathic Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7SFTPD, IL13
2respiratory failure30.5IL13, CMA1, SFTPD
3sarcoidosis30.4SFTPD, IL13
4dermatomyositis30.4CCR7, SFTPD
5idiopathic pulmonary fibrosis30.1IL13, CCR7, SFTPD
6influenza30.0SFTPD, CCR7
7nonspecific interstitial pneumonia10.6
8desquamative interstitial pneumonia10.4
9connective tissue disease10.4
10keratoconjunctivitis10.4IL13
11hypertension10.3
12pulmonary hypertension10.3
13interstitial lung disease10.3
14lung cancer10.3
15vascular disease10.3
16usual interstitial pneumonia10.3
17vernal keratoconjunctivitis10.2IL13, CMA1
18mastocytosis10.2CMA1, IL13
19rhinitis10.2CMA1, IL13
20atopy10.2IL13, CMA1
21dermatitis10.2CMA1, IL13
22arthritis10.2
23acute interstitial pneumonia10.2
24bird fancier's lung10.2
25respiratory bronchiolitis-associated interstitial lung disease10.2
26cryptogenic organizing pneumonia10.2
27lymphoid interstitial pneumonia10.2
28psoriatic arthritis10.2
29myopathy10.2
30airway-centered interstitial fibrosis10.2
31antisynthetase syndrome10.2
32thromboembolism10.2
33pulmonary function10.2
34venous thromboembolism10.2
35blindness10.2
36pulmonary eosinophilia10.2SFTPD, IL13
37atopic dermatitis10.1IL13, CMA1
38chronic obstructive pulmonary disease10.1IL13, SFTPD
39polymyositis10.1CCR7, SFTPD
40tetanus10.1CCR7, IL13
41systemic scleroderma10.1IL13, SFTPD
42cork-handlers' disease10.0IL13, SFTPD
43skin disease10.0SFTPD, IL13
44allergic asthma10.0CMA1, IL13, SFTPD
45immunodeficiency with hyper igm type 210.0CCR7, SFTPD
46psoriasis9.9CMA1, CCR7, IL13
47tongue squamous cell carcinoma9.9ASCL1, CCR7, CMA1
48rheumatoid arthritis9.8SFTPD, CCR7, IL13
49pulmonary fibrosis9.7CMA1, SFTPD, IL13, CCR7
50asthma9.7IL13, CCR7, CMA1, SFTPD

Graphical network of the top 20 diseases related to Idiopathic Interstitial Pneumonia:



Diseases related to idiopathic interstitial pneumonia

Symptoms for Idiopathic Interstitial Pneumonia

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Drugs & Therapeutics for Idiopathic Interstitial Pneumonia

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Drug clinical trials:

Search ClinicalTrials for Idiopathic Interstitial Pneumonia

Search NIH Clinical Center for Idiopathic Interstitial Pneumonia

Genetic Tests for Idiopathic Interstitial Pneumonia

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Anatomical Context for Idiopathic Interstitial Pneumonia

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MalaCards organs/tissues related to Idiopathic Interstitial Pneumonia:

32
Lung, Testes, Bone marrow, Bone, Colon

FMA organs/tissues related to Idiopathic Interstitial Pneumonia:

14
The lung parenchyma of unknown cause

Animal Models for Idiopathic Interstitial Pneumonia or affiliated genes

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MGI Mouse Phenotypes related to Idiopathic Interstitial Pneumonia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3SFTPD, IL13, CCR7, CMA1
2MP:00053888.2IL13, SFTPD, ASCL1, GREM1
3MP:00053878.1SFTPD, CMA1, CCR7, IL13
4MP:00053848.1ASCL1, CCR7, IL13, GREM1

Publications for Idiopathic Interstitial Pneumonia

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Articles related to Idiopathic Interstitial Pneumonia:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia. (24937643)
2014
2
Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients. (24613046)
2014
3
Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia. (24033388)
2014
4
Limitations to the 6-minute walk test in dermatomyositis with interstitial lung disease in comparison with idiopathic interstitial pneumonia. (23400027)
2013
5
Immunohistochemical detection of virus through its nuclear cytopathic effect in idiopathic interstitial pneumonia other than acute exacerbation. (24270907)
2013
6
Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia. (23678265)
2013
7
MMP-7 and fcDNA Serum Levels in Early NSCLC and Idiopathic Interstitial Pneumonia: Preliminary Study. (24336111)
2013
8
Chemotherapy for non-small cell lung cancer complicated by idiopathic interstitial pneumonia. (23741246)
2012
9
Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia. (22212399)
2012
10
Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients. (23106582)
2012
11
Prognostic value of immunohistochemical surfactant protein A expression in regenerative/hyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias. (21435274)
2011
12
Postoperative respiratory failure caused by acute exacerbation of idiopathic interstitial pneumonia. (21487668)
2011
13
Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. (21177844)
2011
14
Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization. (20382190)
2010
15
Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia. (20542676)
2010
16
Predictors of survival in idiopathic interstitial pneumonia. (20707290)
2010
17
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. (19690403)
2010
18
Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function. (19654941)
2009
19
Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumonia. (19017875)
2009
20
TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. (18633634)
2008
21
Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. (18072275)
2008
22
Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia. (18073456)
2008
23
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. (17005585)
2007
24
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. (17334631)
2007
25
Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. (18069415)
2007
26
Pathologic subgroups of nonspecific interstitial pneumonia: differential diagnosis from other idiopathic interstitial pneumonias on high-resolution computed tomography. (16272854)
2005
27
Nonhomogeneous density of CD34 and VCAM-1 alveolar capillaries in major types of idiopathic interstitial pneumonia. (16389728)
2005
28
Semiquantitative 67Ga scintigraphy as an indicator of response to and prognosis after corticosteroid treatment in idiopathic interstitial pneumonia. (16157523)
2005
29
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. (15161635)
2004
30
Angiogenic cytokines in patients with idiopathic interstitial pneumonia. (15223865)
2004
31
A case with acute quadriplegic myopathy following intensive care for idiopathic interstitial pneumonia. (15055401)
2003
32
Idiopathic interstitial pneumonia following stem cell transplantation. (12868990)
2003
33
Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia. (12773329)
2003
34
Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. (12791580)
2003
35
Predicting survival of lung transplantation candidates with idiopathic interstitial pneumonia: does PaO(2) predict survival? (12226013)
2002
36
Steroid treatment based on the findings of transbronchial biopsy in idiopathic interstitial pneumonia. (12449176)
2002
37
Modulation of pulmonary neuroendocrine cells in idiopathic interstitial pneumonia. (12371140)
2002
38
Centrilobular fibrosis: a novel histological pattern of idiopathic interstitial pneumonia. (12440779)
2002
39
Idiopathic interstitial pneumonia: are we missing hypersensitivity pneumonitis? (11814276)
2002
40
The clinical significance of histopathologic subgroups in idiopathic interstitial pneumonia: is surgical lung biopsy essential? (16088685)
2001
41
Nonspecific interstitial pneumonia and the other idiopathic interstitial pneumonias: classification and diagnostic criteria. (10632482)
2000
42
Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (10772122)
2000
43
Surfactant protein A in bronchoalveolar lavage fluid from patients with idiopathic interstitial pneumonia]. (9022314)
1996
44
Lactic dehydrogenase-immunoglobulin G kappa complex in a patient with idiopathic interstitial pneumonia. (8797059)
1996
45
Role of alveolar macrophages in the pathogenesis of idiopathic interstitial pneumonia]. (9216211)
1996
46
Factors affecting prognosis of idiopathic interstitial pneumonia. (8701780)
1996
47
Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic interstitial pneumonia? (8560090)
1995
48
Three cases of idiopathic interstitial pneumonia with bullae seen in schoolteachers. (7485195)
1995
49
A case of severe IgA nephropathy associated with psoriatic arthritis and idiopathic interstitial pneumonia. (8237372)
1993
50
Four cases of lung cancer associated with idiopathic interstitial pneumonia. (2167507)
1990

Variations for Idiopathic Interstitial Pneumonia

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Expression for genes affiliated with Idiopathic Interstitial Pneumonia

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Expression patterns in normal tissues for genes affiliated with Idiopathic Interstitial Pneumonia

Search GEO for disease gene expression data for Idiopathic Interstitial Pneumonia.

Pathways for genes affiliated with Idiopathic Interstitial Pneumonia

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Pathways related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL13, ASCL1

Compounds for genes affiliated with Idiopathic Interstitial Pneumonia

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1scca1449.8IL13, CMA1
2budesonide44 50 1111.7IL13, SFTPD
3nickel44 2410.6CCR7, IL13
4tarc449.6IL13, CCR7
5ccl344 2810.6CCR7, IL13
6ccl444 2810.5CCR7, IL13
7prednisolone44 28 1111.5IL13, SFTPD
8inositol449.4SFTPD, IL13
9allergens449.3CMA1, IL13, SFTPD
10tacrolimus44 50 1111.3CCR7, IL13
11mannose449.3SFTPD, IL13
12histamine44 28 2411.3SFTPD, CMA1, IL13
13endotoxin449.1IL13, SFTPD
14phosphatidylinositol448.9IL13, CCR7, SFTPD
15dexamethasone44 50 28 1111.8SFTPD, IL13, GREM1
16cysteine448.5IL13, SFTPD, CMA1, GREM1
17tyrosine448.2IL13, GREM1, CCR7, ASCL1

GO Terms for genes affiliated with Idiopathic Interstitial Pneumonia

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Cellular components related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL13, CCR7
2extracellular spaceGO:0056158.3GREM1, IL13, SFTPD

Biological processes related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.3IL13, CCR7
2positive regulation of angiogenesisGO:0457668.9GREM1, CMA1

Molecular functions related to Idiopathic Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1GREM1, IL13

Products for genes affiliated with Idiopathic Interstitial Pneumonia

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  • Antibodies
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Sources for Idiopathic Interstitial Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet