IJO
MCID: IDP002
MIFTS: 43

Idiopathic Juvenile Osteoporosis (IJO) malady

Bone diseases category

Summaries for Idiopathic Juvenile Osteoporosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards: Idiopathic Juvenile Osteoporosis, also known as idiopathic osteoporosis, is related to osteoporosis and osteogenesis imperfecta. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds procollagen and clodronate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:63 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

idiopathic juvenile osteoporosis 8 42 10 44
idiopathic osteoporosis 8 44 60
juvenile osteoporosis 8 42 60
osteoporosis, juvenile 42
ijo 42


External Ids:

Disease Ontology8 DOID:12559
ICD9CM27 733.02
SNOMED-CT56 3345002
ICD1025 M80.5, M81.5

Related Diseases for Idiopathic Juvenile Osteoporosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis31.3CALCA, CD36, LRP5, COL1A2, BGLAP, PTH
2osteogenesis imperfecta30.4LRP5, COL1A2, CD36, BGLAP
3ehlers-danlos syndrome30.2COL1A2, CD36
4osteoporosis, early-onset autosomal dominant10.3
5juvenile primary osteoporosis10.1
6blindness10.0LRP5
7cystic fibrosis10.0COL1A2
8hypothyroidism10.0PTH
9nephrolithiasis10.0PTH
10atherosclerosis10.0CD36
11pancreatic islet cell tumors10.0CALCA
12x-linked hypophosphatemia10.0PTH
13parathyroid carcinoma10.0PTH
14hyperphosphatemia10.0PTH
15osteonecrosis10.0BGLAP
16growth hormone deficiency10.0BGLAP
17acromegaly10.0BGLAP
18fibrous dysplasia10.0BGLAP
19calcinosis10.0PTH
20graves' disease10.0BGLAP
21osteogenesis imperfecta type iii10.0COL1A2, CD36
22osteogenesis imperfecta, type ii10.0CD36, COL1A2
23osteogenesis imperfecta type 410.0CD36, COL1A2
24osteosclerosis10.0LRP5, PTH
25dentinogenesis imperfecta10.0CD36, COL1A2
26hypertension10.0CALCA, PTH
27marfan syndrome10.0CD36, COL1A2
28parathyroid adenoma10.0CALCA, PTH
29otosclerosis10.0COL1A2, CD36
30hyperostosis10.0BGLAP, LRP5
31multiple endocrine neoplasia type 2a10.0PTH, CALCA
32connective tissue disease10.0CD36, COL1A2
33osteopetrosis10.0BGLAP, LRP5
34camurati-engelmann disease10.0LRP5, BGLAP
35myeloma10.0BGLAP, CD36
36prostate cancer10.0CD36, BGLAP
37hypogonadism10.0BGLAP, CALCA
38rheumatoid arthritis10.0BGLAP, CD36
39osteofibrous dysplasia10.0BGLAP, CD36
40paget's disease of bone10.0BGLAP, CALCA
41adenoma10.0PTH, CALCA
42osteitis fibrosa10.0PTH, BGLAP
43focal segmental glomerulosclerosis10.0CD36, COL1A2
44arthritis10.0BGLAP, CALCA
45hyperthyroidism10.0PTH, BGLAP
46bone carcinoma10.0CD36, BGLAP
47giant cell tumor10.0CALCA, BGLAP
48autosomal dominant disease10.0PTH, CALCA
49metabolic acidosis10.0BGLAP, PTH
50pseudohypoparathyroidism type 1b10.0BGLAP, PTH

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Clinical Features for Idiopathic Juvenile Osteoporosis

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Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Idiopathic Juvenile Osteoporosis

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

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Anatomical Context for Idiopathic Juvenile Osteoporosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

32
Bone, Skin, Testes

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.9CD36, COL1A2
2MP:00053857.6PTH, LRP5, CD36, CALCA, COL1A2

Publications for Idiopathic Juvenile Osteoporosis

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Sources:
50PubMed
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Articles related to Idiopathic Juvenile Osteoporosis:

(show all 37)
idTitleAuthorsYear
1
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
2
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
3
Coexistence of familial Mediterranean fever and juvenile idiopathic arthritis with osteoporosis successfully treated with etanercept. (20228604)
2010
4
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
5
Effect of pregnancy on bone mineral density and biochemical markers of bone turnover in a patient with juvenile idiopathic osteoporosis. (12510820)
2003
6
Idiopathic juvenile osteoporosis. (11973603)
2002
7
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
8
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
9
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
10
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
11
Idiopathic juvenile osteoporosis. (10818429)
2000
12
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
13
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
14
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
15
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
16
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
17
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
18
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
19
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
20
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
21
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
22
Idiopathic juvenile osteoporosis. (8434248)
1993
23
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
24
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
25
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
26
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
27
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
28
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
29
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
30
Idiopathic juvenile osteoporosis. (6784514)
1981
31
Idiopathic juvenile osteoporosis. (474538)
1979
32
Idiopathic juvenile osteoporosis. (314235)
1979
33
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
34
Idiopathic juvenile osteoporosis. (5459928)
1970
35
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
36
Idiopathic juvenile osteoporosis. (5363391)
1969
37
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Genetic Variations for Idiopathic Juvenile Osteoporosis

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Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CD36, COL1A2
29.2CD36, COL1A2
39.1COL1A2, BGLAP
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.8PTH, CALCA, BGLAP
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
8.5PTH, BGLAP, COL1A2

Compounds for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1procollagen4410.1COL1A2
2clodronate44 49 1111.9CD36, CALCA
3ti6al4v449.9CD36, BGLAP
4tiludronate44 49 1111.9CD36, CALCA
522-oxacalcitriol449.9CD36, BGLAP
6cyanogen bromide449.8COL1A2
7silver nitrate449.8CD36, CALCA
8calcium gluconate449.8BGLAP, CALCA
9alizarin449.8CD36, BGLAP
10ipriflavone449.8BGLAP, CALCA
1124,25-dihydroxyvitamin d3449.8CALCA, BGLAP
12alfacalcidol44 59 1111.8CALCA, BGLAP
13polyglycolic acid449.8BGLAP, CD36
14nandrolone decanoate44 1110.8CALCA, BGLAP
15chitosan449.7CD36, BGLAP
16sodium fluoride449.7CALCA, BGLAP
17thiazide449.7CALCA, BGLAP
18titanium449.6CD36, BGLAP
19tibolone449.6BGLAP, CALCA
20budesonide44 49 1111.6CD36, BGLAP
21alginate449.6CD36, BGLAP
22furosemide44 49 59 28 11 2414.4BGLAP, CALCA
23clonidine44 28 1111.4CALCA, BGLAP
24teriparatide44 1110.4BGLAP, CALCA, CD36
25etidronate449.4BGLAP, CALCA, CD36
26ibandronate44 1110.4CD36, CALCA, BGLAP
27tartrate449.4CD36, CALCA, BGLAP
28vitamin k2449.4CD36, CALCA, BGLAP
29risedronate44 59 49 28 1113.4BGLAP, CALCA, CD36
30mithramycin449.4CALCA, COL1A2
31pyridinoline449.4CD36, CALCA, BGLAP
32zoledronic acid449.4CD36, CALCA, BGLAP
33raloxifene44 28 49 1112.4CD36, CALCA, BGLAP
34fluoride449.3CALCA, BGLAP
35hydrocortisone44 2 59 1112.3BGLAP, CALCA, CD36
36creatinine449.2BGLAP, CD36, PTH
37phosphorus449.2BGLAP, CALCA, PTH
38captopril44 28 49 59 1113.2CD36, CALCA
39thyroxine44 2410.1BGLAP, CALCA, PTH
401,25 dihydroxy vitamin d3448.8BGLAP, CALCA, LRP5, PTH
41calcium carbonate448.8PTH, CD36, CALCA, BGLAP
42pamidronate44 49 1110.8PTH, CD36, CALCA, BGLAP
43deoxypyridinoline448.8BGLAP, CALCA, CD36, PTH
44alendronate44 49 1110.8PTH, CD36, CALCA, BGLAP
4525-hydroxyvitamin d448.8BGLAP, CALCA, CD36, PTH
46hydroxyproline44 11 2410.8PTH, CD36, CALCA, BGLAP
47calcitriol44 59 11 2411.8BGLAP, CALCA, CD36, PTH
48vegf448.6PTH, CD36, CALCA, BGLAP
49vitamin d447.6COL1A2, BGLAP, CALCA, CD36, LRP5, PTH
50calcium44 49 11 2410.5COL1A2, BGLAP, CALCA, CD36, LRP5, PTH

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

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16Gene Ontology
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Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0PTH, CALCA, BGLAP, COL1A2
2extracellular spaceGO:0056157.7PTH, CALCA, BGLAP, COL1A2

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:0020769.6LRP5, BGLAP
2positive regulation of cAMP biosynthetic processGO:0308199.2PTH, CALCA
3odontogenesisGO:0424769.1COL1A2, BGLAP
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.0PTH, CALCA
5Rho protein signal transductionGO:0072669.0PTH, COL1A2
6regulation of blood pressureGO:0082178.9LRP5, CALCA, COL1A2
7skeletal system developmentGO:0015018.6PTH, BGLAP, COL1A2

Products for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources for Idiopathic Juvenile Osteoporosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet