IJO
MCID: IDP002
MIFTS: 50

Idiopathic Juvenile Osteoporosis (IJO) malady

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

Aliases & Descriptions for Idiopathic Juvenile Osteoporosis:

Name: Idiopathic Juvenile Osteoporosis 12 50 56 52 14
Juvenile Osteoporosis 12 50 56 69
Idiopathic Osteoporosis 12 52 69
Ijo 50 56
Osteoporosis, Juvenile 50

Characteristics:

Orphanet epidemiological data:

56
idiopathic juvenile osteoporosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood;

HPO:

32
idiopathic juvenile osteoporosis:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:12559
ICD9CM 35 733.02
SNOMED-CT 64 3345002
Orphanet 56 ORPHA85193
ICD10 via Orphanet 34 M81.5
ICD10 33 M80.5 M81.5
UMLS 69 C0158447

Summaries for Idiopathic Juvenile Osteoporosis

NIH Rare Diseases : 50 juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards based summary : Idiopathic Juvenile Osteoporosis, also known as juvenile osteoporosis, is related to juvenile primary osteoporosis and osteoporosis, and has symptoms including bone pain, gait disturbance and kyphosis. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (LDL Receptor Related Protein 5), and among its related pathways/superpathways are Glioma and Signaling by Wnt. The drugs Alendronate and Pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are craniofacial and embryo

Disease Ontology : 12 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia : 71 Juvenile osteoporosis is osteoporosis in children and... more...

Related Diseases for Idiopathic Juvenile Osteoporosis

Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 juvenile primary osteoporosis 11.0
2 osteoporosis 10.5
3 adult ependymoblastoma 10.2 BGLAP CALCA
4 hypophosphatasia, adult 10.2 BGLAP CALCA
5 mesenchymal cell neoplasm 10.2 BGLAP CALCA
6 maroteaux stanescu cousin syndrome 10.2 BGLAP CALCA
7 endemic goiter 10.2 BGLAP CALCA
8 childhood brain meningioma 10.1 CALCA LRP5
9 bladder papillary transitional cell neoplasm 10.1 BGLAP CALCA DKK1
10 ichthyosis, acquired 10.1 LRP5 WNT3A
11 sohval soffer syndrome 10.1 IGF1 IGFBP3
12 frontotemporal lobar degeneration with ubiquitin-positive inclusions 10.1 COL1A1 LRP5 LRP6
13 robinow syndrome 10.1 COL1A1 LRP5 LRP6
14 seow najjar syndrome 10.0 IGF1 IGFBP3
15 microtia, hearing impairment, and cleft palate 10.0 IGF1 IGFBP3
16 axial osteomalacia 10.0 BGLAP CALCA IGF1
17 spondylometaphyseal dysplasia, megarbane-dagher-melike type 10.0 IGF1 IGFBP3
18 capgras syndrome 10.0 IGF1 IGFBP3
19 diarrhea 3, secretory sodium, congenital, syndromic 10.0 IGF1 IGFBP3
20 lipodystrophy, familial partial, type 6 10.0 BGLAP LRP5
21 prostatocystitis 10.0 BGLAP COL1A1 WNT1
22 pituitary adenoma, acth-secreting 10.0 IGF1 IGFBP3
23 epileptic encephalopathy, early infantile, 24 10.0 IGF1 IGFBP3
24 hyperinsulinemic hypoglycemia, familial, 5 9.9 IGF1 IGFBP3
25 albinism, oculocutaneous, type ib 9.9 IGF1 IGFBP3 LRP5
26 central nervous system leiomyoma 9.9 BGLAP IGF1 IGFBP3
27 extrahepatic bile duct adenocarcinoma 9.9 BGLAP IGF1 IGFBP3
28 protein s deficiency 9.9 IGF1 IGFBP3
29 ischemic bone disease 9.9 BGLAP CALCA IGF1 LRP5
30 edict syndrome 9.9 BGLAP IGF1 IGFBP3
31 osteogenesis imperfecta 9.9
32 acrorenal syndrome 9.9 BGLAP CALCA DKK1 IGF1
33 fibrogenesis imperfecta ossium 9.8 CALCA LRP5 LRP6 WNT1 WNT3A
34 post-traumatic stress disorder 9.7 COL1A1 IGF1 IGFBP3 LRP5
35 mental retardation, autosomal recessive 35 9.7 BGLAP COL1A1 IGF1 IGFBP3
36 lymphoma 9.7
37 scoliosis 9.7
38 ehlers-danlos syndrome 9.7
39 back pain 9.7
40 ehlers-danlos syndrome, cardiac valvular form 9.6 BGLAP COL1A1 IGF1 IGFBP3 WNT1
41 dysbaric osteonecrosis 9.5 BGLAP CALCA COL1A1 DKK1 IGF1 LRP5
42 carnitine deficiency, systemic primary 8.6 BGLAP CALCA COL1A1 DKK1 GC IGF1
43 phacolytic glaucoma 8.6 BGLAP CALCA COL1A1 DKK1 GC IGF1

Comorbidity relations with Idiopathic Juvenile Osteoporosis via Phenotypic Disease Network (PDN):


Osteoporosis

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to Idiopathic Juvenile Osteoporosis

Symptoms & Phenotypes for Idiopathic Juvenile Osteoporosis

Human phenotypes related to Idiopathic Juvenile Osteoporosis:

56 32 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 bone pain 56 32 Very frequent (99-80%) HP:0002653
2 gait disturbance 56 32 Frequent (79-30%) HP:0001288
3 kyphosis 56 32 Occasional (29-5%) HP:0002808
4 osteoporosis 56 32 Very frequent (99-80%) HP:0000939
5 recurrent fractures 56 32 Very frequent (99-80%) HP:0002757
6 vertebral compression fractures 56 32 Frequent (79-30%) HP:0002953
7 low serum calcitriol 32 HP:0012052

MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.91 COL1A1 DKK1 LRP5 LRP6 WNT1 WNT3A
2 embryo MP:0005380 9.88 COL1A1 DKK1 LRP5 LRP6 WNT1 WNT3A
3 endocrine/exocrine gland MP:0005379 9.85 COL1A1 GC IGF1 IGFBP3 LRP5 WNT1
4 limbs/digits/tail MP:0005371 9.73 COL1A1 DKK1 IGF1 LRP5 LRP6 WNT3A
5 hearing/vestibular/ear MP:0005377 9.72 LRP6 WNT1 WNT3A COL1A1 IGF1
6 renal/urinary system MP:0005367 9.55 COL1A1 DKK1 IGF1 LRP6 WNT3A
7 respiratory system MP:0005388 9.43 COL1A1 DKK1 IGF1 LRP6 WNT1 WNT3A
8 skeleton MP:0005390 9.23 COL1A1 DKK1 GC IGF1 LRP5 LRP6

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

Drugs for Idiopathic Juvenile Osteoporosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
2
Pamidronate Approved Phase 4 40391-99-9 4674
3 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
4 Diphosphonates Phase 4,Phase 2
5
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
6
Naproxen Approved, Vet_approved Phase 3 22204-53-1 1302 156391
7
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
8
Norepinephrine Approved Phase 3 51-41-2 439260
9 glucocorticoids Phase 2, Phase 3,Phase 1
10 Analgesics Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antirheumatic Agents Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Antidepressive Agents Phase 3
18 Dopamine Agents Phase 3
19 Duloxetine Hydrochloride Phase 3
20 Neurotransmitter Agents Phase 3
21 Neurotransmitter Uptake Inhibitors Phase 3
22 Psychotropic Drugs Phase 3
23
Serotonin Phase 3 50-67-9 5202
24 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
25 Aluminum sulfate Phase 3
26 insulin Phase 3
27 Insulin, Globin Zinc Phase 3
28
Calcium carbonate Approved Phase 2 471-34-1
29
Denosumab Approved Phase 1, Phase 2 615258-40-7
30
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
31
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
32 Calcium, Dietary Phase 2
33 Ergocalciferols Phase 2
34 Micronutrients Phase 2
35 Trace Elements Phase 2
36 vitamin d Phase 2
37 Vitamins Phase 2
38 Hormone Antagonists Phase 1, Phase 2
39 Hormones Phase 1, Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
41 Calcium Supplement Nutraceutical Phase 2
42 Calciferol Nutraceutical Phase 2
43 Vitamin D2 Nutraceutical Phase 2

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4
2 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3
3 Meloxicam [Mobic] in Juvenile Rheumatoid Arthritis (JRA) Completed NCT00034853 Phase 3
4 A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia Syndrome Recruiting NCT01237587 Phase 3
5 A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (USA)- DIAPREVENT Terminated NCT00751842 Phase 3
6 Phase II Study of Alendronate Sodium in Children With High-Turnover Idiopathic Juvenile Osteoporosis Completed NCT00010439 Phase 2
7 Treatment of Childhood Osteoporosis With Alendronate (Fosamax) Completed NCT00001720 Phase 2
8 Safety and Efficacy of Alendronate (Fosamax) in Children With Osteoporosis Completed NCT00259857 Phase 2
9 Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders Not yet recruiting NCT02418273 Phase 1, Phase 2
10 Rheumatology Clinical Registry Unknown status NCT01813409
11 Alendronate in Juvenile Osteoporosis Completed NCT00920075
12 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
13 Spine Quantitative Computed Tomography (QCT) Active, not recruiting NCT00762879
14 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Active, not recruiting NCT01663129

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

Anatomical Context for Idiopathic Juvenile Osteoporosis

MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

39
Bone, Testes, Skin

Publications for Idiopathic Juvenile Osteoporosis

Articles related to Idiopathic Juvenile Osteoporosis:

(show all 40)
id Title Authors Year
1
Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes. ( 25783012 )
2015
2
Evidence of Altered Matrix Composition in Iliac Crest Biopsies from Patients with Idiopathic Juvenile Osteoporosis. ( 26539896 )
2015
3
Idiopathic Juvenile Osteoporosis: A Case Report. ( 26436063 )
2015
4
Idiopathic juvenile osteoporosis: A case report and review of the literature. ( 25768278 )
2015
5
Radiographic and MR Imaging Findings of the Spine after Bisphosphonate Treatment, in a Child with Idiopathic Juvenile Osteoporosis. ( 25688321 )
2015
6
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. ( 23418950 )
2013
7
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. ( 23549954 )
2013
8
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. ( 16951909 )
2006
9
Idiopathic juvenile osteoporosis. ( 11973603 )
2002
10
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. ( 12110417 )
2002
11
Clinical evaluation of patients with idiopathic juvenile osteoporosis. ( 11497372 )
2001
12
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. ( 11496161 )
2001
13
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. ( 11086654 )
2000
14
Idiopathic juvenile osteoporosis. ( 10818429 )
2000
15
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. ( 10804027 )
2000
16
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. ( 9458225 )
1998
17
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. ( 8816205 )
1996
18
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. ( 8581446 )
1995
19
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. ( 7584708 )
1995
20
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. ( 7900745 )
1995
21
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. ( 7671570 )
1995
22
Idiopathic juvenile osteoporosis: five-year case follow-up. ( 7613264 )
1995
23
Idiopathic juvenile osteoporosis: experience of twenty-one patients. ( 7881843 )
1995
24
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? ( 7882130 )
1995
25
Idiopathic juvenile osteoporosis. ( 8434248 )
1993
26
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. ( 1393771 )
1992
27
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. ( 2012031 )
1991
28
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. ( 3177335 )
1988
29
Bone metabolism in idiopathic juvenile osteoporosis: a case report. ( 6839191 )
1983
30
Calcitriol deficiency in idiopathic juvenile osteoporosis. ( 6896958 )
1982
31
Idiopathic juvenile osteoporosis and scoliosis. ( 7130387 )
1982
32
Spinal deformity in idiopathic juvenile osteoporosis. ( 7209670 )
1981
33
Idiopathic juvenile osteoporosis. ( 6784514 )
1981
34
Idiopathic juvenile osteoporosis. ( 474538 )
1979
35
Idiopathic juvenile osteoporosis. ( 314235 )
1979
36
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. ( 891571 )
1977
37
Idiopathic juvenile osteoporosis. ( 5459928 )
1970
38
Idiopathic juvenile osteoporosis: report of a case and review of the literature. ( 4908113 )
1969
39
Idiopathic juvenile osteoporosis. ( 5363391 )
1969
40
IDIOPATHIC JUVENILE OSTEOPOROSIS. ( 14319616 )
1965

Variations for Idiopathic Juvenile Osteoporosis

Expression for Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for Idiopathic Juvenile Osteoporosis

Pathways related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 IGF1 LRP5 LRP6 WNT1 WNT3A
2
Show member pathways
12.74 DKK1 LRP5 LRP6 WNT1 WNT3A
3
Show member pathways
12.4 DKK1 LRP5 LRP6 WNT1 WNT3A
4
Show member pathways
12.37 DKK1 LRP5 LRP6 WNT1 WNT3A
5
Show member pathways
12.32 IGF1 LRP5 LRP6 WNT1 WNT3A
6 12.23 DKK1 LRP5 LRP6 WNT1 WNT3A
7 12.12 IGF1 WNT1 WNT3A
8 12.12 DKK1 LRP5 LRP6 WNT3A
9 12.07 LRP5 LRP6 WNT1 WNT3A
10
Show member pathways
12.04 IGF1 LRP5 LRP6 WNT3A
11
Show member pathways
12 DKK1 LRP5 LRP6 WNT1 WNT3A
12
Show member pathways
11.97 IGF1 WNT1 WNT3A
13 11.94 IGF1 WNT1 WNT3A
14 11.92 DKK1 IGF1 WNT3A
15 11.83 DKK1 LRP5 LRP6 WNT1
16 11.81 COL1A1 IGF1 IGFBP3
17 11.75 BGLAP IGF1 IGFBP3
18 11.57 DKK1 LRP5 LRP6 WNT1
19 11.48 DKK1 IGF1 WNT3A
20 11.41 DKK1 LRP6 WNT1
21 11.3 DKK1 IGF1 WNT1 WNT3A
22 11.23 BGLAP COL1A1
23 11.21 BGLAP CALCA COL1A1 IGF1
24
Show member pathways
11.18 LRP5 LRP6 WNT3A
25 10.96 IGF1 IGFBP3
26 10.84 DKK1 LRP5 LRP6 WNT1
27 10.76 BGLAP COL1A1
28
Show member pathways
10.58 DKK1 LRP5 LRP6 WNT3A
29 10.47 DKK1 LRP5 LRP6 WNT1 WNT3A

GO Terms for Idiopathic Juvenile Osteoporosis

Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 BGLAP CALCA COL1A1 DKK1 GC IGF1
2 endoplasmic reticulum lumen GO:0005788 9.65 BGLAP COL1A1 IGFBP3 WNT1 WNT3A
3 early endosome membrane GO:0031901 9.63 DKK1 LRP6 WNT3A
4 Golgi lumen GO:0005796 9.61 BGLAP WNT1 WNT3A
5 Wnt signalosome GO:1990909 9.4 LRP5 LRP6
6 insulin-like growth factor ternary complex GO:0042567 9.37 IGF1 IGFBP3
7 insulin-like growth factor binding protein complex GO:0016942 9.32 IGF1 IGFBP3
8 extracellular space GO:0005615 9.28 BGLAP CALCA COL1A1 DKK1 GC IGF1
9 Wnt-Frizzled-LRP5/6 complex GO:1990851 9.13 LRP5 LRP6 WNT3A

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.94 IGF1 LRP5 WNT1 WNT3A
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 COL1A1 IGF1 LRP5 LRP6 WNT1 WNT3A
3 cellular protein metabolic process GO:0044267 9.84 CALCA IGF1 IGFBP3
4 skeletal system development GO:0001501 9.79 BGLAP COL1A1 IGF1
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.76 COL1A1 LRP6 WNT1 WNT3A
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.73 LRP5 LRP6 WNT1 WNT3A
7 bone development GO:0060348 9.72 BGLAP LRP5 WNT1
8 response to peptide hormone GO:0043434 9.71 COL1A1 LRP5 LRP6
9 osteoblast differentiation GO:0001649 9.71 BGLAP COL1A1 IGFBP3 WNT3A
10 midbrain development GO:0030901 9.67 WNT1 WNT3A
11 positive regulation of receptor activity GO:2000273 9.66 WNT1 WNT3A
12 negative regulation of protein serine/threonine kinase activity GO:0071901 9.65 LRP5 LRP6
13 positive regulation of mitotic nuclear division GO:0045840 9.65 IGF1 LRP5
14 dopaminergic neuron differentiation GO:0071542 9.65 LRP6 WNT1
15 face morphogenesis GO:0060325 9.65 COL1A1 DKK1 LRP6
16 Wnt signaling pathway GO:0016055 9.65 DKK1 LRP5 LRP6 WNT1 WNT3A
17 regulation of canonical Wnt signaling pathway GO:0060828 9.64 LRP5 LRP6
18 vasculature development GO:0001944 9.63 CALCA LRP5
19 negative regulation of ossification GO:0030279 9.62 CALCA DKK1
20 canonical Wnt signaling pathway GO:0060070 9.62 LRP5 LRP6 WNT1 WNT3A
21 osteoblast development GO:0002076 9.61 BGLAP LRP5
22 negative regulation of cell-substrate adhesion GO:0010812 9.61 COL1A1 WNT1
23 spinal cord association neuron differentiation GO:0021527 9.6 WNT1 WNT3A
24 midbrain dopaminergic neuron differentiation GO:1904948 9.59 LRP6 WNT1
25 cell proliferation in midbrain GO:0033278 9.58 WNT1 WNT3A
26 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.58 IGF1 LRP6
27 Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 9.57 LRP5 LRP6
28 midbrain-hindbrain boundary development GO:0030917 9.56 LRP6 WNT1
29 Wnt signaling pathway involved in somitogenesis GO:0090244 9.52 DKK1 LRP6
30 axis elongation involved in somitogenesis GO:0090245 9.51 LRP6 WNT3A
31 positive regulation of dermatome development GO:0061184 9.49 WNT1 WNT3A
32 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.33 IGF1 IGFBP3 WNT1
33 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953 9.13 LRP6 WNT1 WNT3A
34 beta-catenin destruction complex disassembly GO:1904886 8.92 LRP5 LRP6 WNT1 WNT3A
35 multicellular organism development GO:0007275 10.06 DKK1 LRP5 LRP6 WNT1 WNT3A
36 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.03 IGF1 LRP5 LRP6 WNT1 WNT3A

Molecular functions related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.67 CALCA LRP6 WNT1 WNT3A
2 Wnt-protein binding GO:0017147 9.46 LRP5 LRP6
3 receptor agonist activity GO:0048018 9.43 WNT1 WNT3A
4 Wnt-activated receptor activity GO:0042813 9.4 LRP5 LRP6
5 frizzled binding GO:0005109 9.33 LRP6 WNT1 WNT3A
6 co-receptor binding GO:0039706 9.32 DKK1 WNT3A
7 toxin transporter activity GO:0019534 9.26 LRP5 LRP6
8 coreceptor activity involved in Wnt signaling pathway GO:0071936 8.96 LRP5 LRP6
9 coreceptor activity involved in canonical Wnt signaling pathway GO:1904928 8.62 LRP5 LRP6

Sources for Idiopathic Juvenile Osteoporosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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