IJO
MCID: IDP002
MIFTS: 38

Idiopathic Juvenile Osteoporosis (IJO) malady

Bone category

Summaries for Idiopathic Juvenile Osteoporosis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards: Idiopathic Juvenile Osteoporosis, also known as idiopathic osteoporosis, is related to osteoporosis and osteogenesis imperfecta. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds procollagen and clodronate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and skin, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:64 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

idiopathic juvenile osteoporosis 8 43 10 45
idiopathic osteoporosis 8 45 61
juvenile osteoporosis 8 43 61
osteoporosis, juvenile 43
ijo 43


External Ids:

Disease Ontology8 DOID:12559
ICD9CM27 733.02
SNOMED-CT57 3345002
ICD1025 M80.5, M81.5

Related Diseases for Idiopathic Juvenile Osteoporosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis31.3CALCA, CD36, LRP5, COL1A2, BGLAP, PTH
2osteogenesis imperfecta30.4LRP5, COL1A2, CD36, BGLAP
3osteoporosis, early-onset autosomal dominant10.3
4ehlers–danlos syndrome10.2
5juvenile primary osteoporosis10.2
6back pain10.2
7ehlers-danlos/osteogenesis imperfecta syndrome10.2
8blindness10.0LRP5
9cystic fibrosis10.0COL1A2
10hypothyroidism10.0PTH
11nephrolithiasis10.0PTH
12atherosclerosis10.0CD36
13pancreatic islet cell tumors10.0CALCA
14x-linked hypophosphatemia10.0PTH
15parathyroid carcinoma10.0PTH
16hyperphosphatemia10.0PTH
17osteonecrosis10.0BGLAP
18growth hormone deficiency10.0BGLAP
19acromegaly10.0BGLAP
20fibrous dysplasia10.0BGLAP
21calcinosis10.0PTH
22graves' disease10.0BGLAP
23osteogenesis imperfecta type iii10.0COL1A2, CD36
24osteogenesis imperfecta, type ii10.0CD36, COL1A2
25osteogenesis imperfecta type 410.0CD36, COL1A2
26osteosclerosis10.0LRP5, PTH
27dentinogenesis imperfecta10.0CD36, COL1A2
28hypertension10.0CALCA, PTH
29marfan syndrome10.0CD36, COL1A2
30parathyroid adenoma10.0CALCA, PTH
31otosclerosis10.0COL1A2, CD36
32hyperostosis10.0BGLAP, LRP5
33multiple endocrine neoplasia type 2a10.0PTH, CALCA
34connective tissue disease10.0CD36, COL1A2
35osteopetrosis10.0BGLAP, LRP5
36camurati-engelmann disease10.0LRP5, BGLAP
37myeloma10.0BGLAP, CD36
38prostate cancer10.0CD36, BGLAP
39hypogonadism10.0BGLAP, CALCA
40rheumatoid arthritis10.0BGLAP, CD36
41osteofibrous dysplasia10.0BGLAP, CD36
42paget's disease of bone10.0BGLAP, CALCA
43adenoma10.0PTH, CALCA
44osteitis fibrosa10.0PTH, BGLAP
45focal segmental glomerulosclerosis10.0CD36, COL1A2
46arthritis10.0BGLAP, CALCA
47hyperthyroidism10.0PTH, BGLAP
48bone carcinoma10.0CD36, BGLAP
49giant cell tumor10.0CALCA, BGLAP
50autosomal dominant disease10.0PTH, CALCA

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Clinical Features for Idiopathic Juvenile Osteoporosis

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Idiopathic Juvenile Osteoporosis

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

Anatomical Context for Idiopathic Juvenile Osteoporosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

33
Skeletal muscle, Skin

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.9CD36, COL1A2
2MP:00053857.6PTH, LRP5, CD36, CALCA, COL1A2

Publications for Idiopathic Juvenile Osteoporosis

Sources:
51PubMed
See all sources

Articles related to Idiopathic Juvenile Osteoporosis:

(show all 38)
idTitleAuthorsYear
1
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
2
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
3
Coexistence of familial Mediterranean fever and juvenile idiopathic arthritis with osteoporosis successfully treated with etanercept. (20228604)
2010
4
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
5
Effect of pregnancy on bone mineral density and biochemical markers of bone turnover in a patient with juvenile idiopathic osteoporosis. (12510820)
2003
6
Idiopathic juvenile osteoporosis. (11973603)
2002
7
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
8
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
9
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
10
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
11
Idiopathic juvenile osteoporosis. (10818429)
2000
12
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
13
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
14
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
15
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
16
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
17
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
18
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
19
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
20
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
21
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
22
Idiopathic juvenile osteoporosis. (8434248)
1993
23
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
24
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
25
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
26
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
27
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
28
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
29
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
30
Idiopathic juvenile osteoporosis. (6784514)
1981
31
Idiopathic juvenile osteoporosis. (474538)
1979
32
Idiopathic juvenile osteoporosis. (314235)
1979
33
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
34
Lymphoma presenting as "Idiopathic" juvenile osteoporosis. (1125676)
1975
35
Idiopathic juvenile osteoporosis. (5459928)
1970
36
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
37
Idiopathic juvenile osteoporosis. (5363391)
1969
38
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Genetic Variations for Idiopathic Juvenile Osteoporosis

Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CD36, COL1A2
29.2CD36, COL1A2
39.1COL1A2, BGLAP
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.8PTH, CALCA, BGLAP
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
8.5PTH, BGLAP, COL1A2

Compounds for genes affiliated with Idiopathic Juvenile Osteoporosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1procollagen4510.1COL1A2
2clodronate45 50 1111.9CD36, CALCA
3ti6al4v459.9CD36, BGLAP
4tiludronate45 50 1111.9CD36, CALCA
522-oxacalcitriol459.9CD36, BGLAP
6cyanogen bromide459.8COL1A2
7silver nitrate459.8CD36, CALCA
8calcium gluconate459.8BGLAP, CALCA
9alizarin459.8CD36, BGLAP
10ipriflavone459.8BGLAP, CALCA
1124,25-dihydroxyvitamin d3459.8CALCA, BGLAP
12alfacalcidol45 60 1111.8CALCA, BGLAP
13polyglycolic acid459.8BGLAP, CD36
14nandrolone decanoate45 1110.8CALCA, BGLAP
15chitosan459.7CD36, BGLAP
16sodium fluoride459.7CALCA, BGLAP
17thiazide459.7CALCA, BGLAP
18titanium459.6CD36, BGLAP
19tibolone459.6BGLAP, CALCA
20budesonide45 50 1111.6CD36, BGLAP
21alginate459.6CD36, BGLAP
22furosemide45 50 60 29 11 2414.4BGLAP, CALCA
23clonidine45 29 1111.4CALCA, BGLAP
24teriparatide45 1110.4BGLAP, CALCA, CD36
25etidronate459.4BGLAP, CALCA, CD36
26ibandronate45 1110.4CD36, CALCA, BGLAP
27tartrate459.4CD36, CALCA, BGLAP
28vitamin k2459.4CD36, CALCA, BGLAP
29risedronate45 60 50 29 1113.4BGLAP, CALCA, CD36
30mithramycin459.4CALCA, COL1A2
31pyridinoline459.4CD36, CALCA, BGLAP
32zoledronic acid459.4CD36, CALCA, BGLAP
33raloxifene45 29 50 1112.4CD36, CALCA, BGLAP
34fluoride459.3CALCA, BGLAP
35hydrocortisone45 2 60 1112.3BGLAP, CALCA, CD36
36creatinine459.2BGLAP, CD36, PTH
37phosphorus459.2BGLAP, CALCA, PTH
38captopril45 29 50 60 1113.2CD36, CALCA
39thyroxine45 2410.1BGLAP, CALCA, PTH
401,25 dihydroxy vitamin d3458.8BGLAP, CALCA, LRP5, PTH
41calcium carbonate458.8PTH, CD36, CALCA, BGLAP
42pamidronate45 50 1110.8PTH, CD36, CALCA, BGLAP
43deoxypyridinoline458.8BGLAP, CALCA, CD36, PTH
44alendronate45 50 1110.8PTH, CD36, CALCA, BGLAP
4525-hydroxyvitamin d458.8BGLAP, CALCA, CD36, PTH
46hydroxyproline45 11 2410.8PTH, CD36, CALCA, BGLAP
47calcitriol45 60 11 2411.8BGLAP, CALCA, CD36, PTH
48vegf458.6PTH, CD36, CALCA, BGLAP
49vitamin d457.6COL1A2, BGLAP, CALCA, CD36, LRP5, PTH
50calcium45 50 11 2410.5COL1A2, BGLAP, CALCA, CD36, LRP5, PTH

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0PTH, CALCA, BGLAP, COL1A2
2extracellular spaceGO:0056157.7PTH, CALCA, BGLAP, COL1A2

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:0020769.6LRP5, BGLAP
2positive regulation of cAMP biosynthetic processGO:0308199.2PTH, CALCA
3odontogenesisGO:0424769.1COL1A2, BGLAP
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.0PTH, CALCA
5Rho protein signal transductionGO:0072669.0PTH, COL1A2
6regulation of blood pressureGO:0082178.9LRP5, CALCA, COL1A2
7skeletal system developmentGO:0015018.6PTH, BGLAP, COL1A2

Products for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources for Idiopathic Juvenile Osteoporosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet