MCID: IDP002
MIFTS: 48

Idiopathic Juvenile Osteoporosis

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

MalaCards integrated aliases for Idiopathic Juvenile Osteoporosis:

Name: Idiopathic Juvenile Osteoporosis 12 50 56 52 14
Juvenile Osteoporosis 12 50 56 69
Idiopathic Osteoporosis 12 52 69
Ijo 50 56
Osteoporosis, Juvenile 50

Characteristics:

Orphanet epidemiological data:

56
idiopathic juvenile osteoporosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood;

HPO:

32
idiopathic juvenile osteoporosis:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:12559
ICD9CM 35 733.02
SNOMED-CT 64 3345002
Orphanet 56 ORPHA85193
UMLS via Orphanet 70 C0264080
ICD10 via Orphanet 34 M81.5
ICD10 33 M80.5 M81.5
UMLS 69 C0158447

Summaries for Idiopathic Juvenile Osteoporosis

NIH Rare Diseases : 50 juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards based summary : Idiopathic Juvenile Osteoporosis, also known as juvenile osteoporosis, is related to juvenile primary osteoporosis and mixed cell type adenoma of parathyroid, and has symptoms including kyphosis, vertebral compression fractures and osteoporosis. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (LDL Receptor Related Protein 5), and among its related pathways/superpathways are Signaling by Wnt and Wnt Signaling Pathway and Pluripotency. The drugs Alendronate and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are craniofacial and embryo

Disease Ontology : 12 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia : 72 Juvenile osteoporosis is osteoporosis in children and adolescents.Osteoporosis is rare in children and... more...

Related Diseases for Idiopathic Juvenile Osteoporosis

Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 juvenile primary osteoporosis 11.0
2 mixed cell type adenoma of parathyroid 10.6 BGLAP CALCA
3 xanthomatosis 10.6 BGLAP CALCA
4 hypophosphatasia, adult 10.6 BGLAP CALCA
5 endemic goiter 10.6 BGLAP CALCA
6 bladder transitional cell papilloma 10.6 CALCA LRP5
7 osteoporosis 10.5
8 ichthyosis deafness mental retardation skeletal anomaly 10.5 LRP5 WNT3A
9 hypoinsulinemic hypoglycemia with hemihypertrophy 10.4 BGLAP LRP5
10 pes anserinus tendinitis or bursitis 10.4 BGLAP CALCA
11 opioid abuse 10.4 BGLAP CALCA
12 pontocerebellar hypoplasia, type 2e 10.3 COL1A1 WNT3A
13 bradyopsia 10.3 COL1A1 LRP5
14 astrakhan spotted fever 10.3 BGLAP CALCA
15 brain injury 10.2 BGLAP LRP5
16 schizoaffective disorder 10.2 BGLAP CALCA DKK1
17 carcinoma of unknown primary site, childhood 10.2 CALCA IGF1
18 small cell lung cancer, childhood 10.1 IGF1 IGFBP3
19 scapuloperoneal myopathy 10.1 COL1A1 LRP5 LRP6
20 selenium poisoning 10.1 IGF1 IGFBP3
21 lipase deficiency, combined 10.1 IGF1 IGFBP3
22 pulmonary large cell neuroendocrine carcinoma 10.1 IGF1 IGFBP3
23 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.1 IGF1 IGFBP3
24 hyperlipoproteinemia, type ib 10.0 IGF1 IGFBP3
25 worth's syndrome 10.0 BGLAP CALCA IGF1
26 protein s deficiency 10.0 IGF1 IGFBP3
27 chronic myelomonocytic leukemia 10.0 BGLAP CALCA IGF1
28 growth hormone insensitivity, partial 10.0 IGF1 IGFBP3
29 osteogenesis imperfecta, type iii 10.0 COL1A1 WNT1
30 prostatocystitis 10.0 BGLAP COL1A1 WNT1
31 pituitary adenoma, prolactin-secreting 10.0 IGF1 IGFBP3
32 glomerulosclerosis, focal segmental, 1 10.0 IGF1 IGFBP3
33 tinea unguium 10.0 BGLAP CALCA
34 fetal parvovirus syndrome 9.9 IGF1 IGFBP3
35 osteogenesis imperfecta 9.9
36 post-traumatic stress disorder 9.8 COL1A1 IGF1 LRP5
37 albinism, oculocutaneous, type ia 9.8 IGF1 IGFBP3 LRP5
38 bile duct signet ring cell carcinoma 9.8 BGLAP IGF1 IGFBP3
39 lung cancer susceptibility 2 9.8 BGLAP IGF1 IGFBP3
40 thrombophilia 9.8 BGLAP IGF1 IGFBP3
41 bone deterioration disease 9.8 BGLAP CALCA IGF1 LRP5
42 ehlers-danlos syndrome 9.7
43 back pain 9.7
44 lymphoma 9.7
45 scoliosis 9.7
46 pericardial tuberculosis 9.6 IGF1 IGFBP3
47 bacillary angiomatosis 9.6 BGLAP CALCA DKK1 IGF1
48 axial osteomalacia 9.6 CALCA LRP5 LRP6 WNT1 WNT3A
49 osteogenesis imperfecta, type ii 9.5 BGLAP COL1A1 IGFBP3 WNT1
50 caffey disease 9.3 BGLAP COL1A1 IGF1 IGFBP3

Comorbidity relations with Idiopathic Juvenile Osteoporosis via Phenotypic Disease Network (PDN):


Osteoporosis

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to Idiopathic Juvenile Osteoporosis

Symptoms & Phenotypes for Idiopathic Juvenile Osteoporosis

Human phenotypes related to Idiopathic Juvenile Osteoporosis:

56 32 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 kyphosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0002808
2 vertebral compression fractures 56 32 frequent (33%) Frequent (79-30%) HP:0002953
3 osteoporosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000939
4 recurrent fractures 56 32 hallmark (90%) Very frequent (99-80%) HP:0002757
5 bone pain 56 32 hallmark (90%) Very frequent (99-80%) HP:0002653
6 gait disturbance 56 32 frequent (33%) Frequent (79-30%) HP:0001288
7 low serum calcitriol 32 HP:0012052

MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.88 COL1A1 DKK1 LRP5 LRP6 WNT1 WNT3A
2 embryo MP:0005380 9.85 LRP5 LRP6 WNT1 WNT3A COL1A1 DKK1
3 limbs/digits/tail MP:0005371 9.73 IGF1 LRP5 LRP6 WNT3A COL1A1 DKK1
4 hearing/vestibular/ear MP:0005377 9.72 COL1A1 IGF1 LRP6 WNT1 WNT3A
5 renal/urinary system MP:0005367 9.55 COL1A1 DKK1 IGF1 LRP6 WNT3A
6 respiratory system MP:0005388 9.43 COL1A1 DKK1 IGF1 LRP6 WNT1 WNT3A
7 skeleton MP:0005390 9.23 COL1A1 DKK1 GC IGF1 LRP5 LRP6

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

Drugs for Idiopathic Juvenile Osteoporosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
2
Calcium Carbonate Approved Phase 2 471-34-1
3
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
4
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
6 Bone Density Conservation Agents Phase 2
7 Calcium, Dietary Phase 2
8 Diphosphonates Phase 2
9 glucocorticoids Phase 2
10 Ergocalciferols Phase 2
11 Micronutrients Phase 2
12 Trace Elements Phase 2
13 Vitamins Phase 2
14 Calcium Supplement Nutraceutical Phase 2
15 Calciferol Nutraceutical Phase 2
16 Vitamin D2 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase II Study of Alendronate Sodium in Children With High-Turnover Idiopathic Juvenile Osteoporosis Completed NCT00010439 Phase 2 Alendronate
2 Treatment of Childhood Osteoporosis With Alendronate (Fosamax) Completed NCT00001720 Phase 2 Alendronate
3 Safety and Efficacy of Alendronate (Fosamax) in Children With Osteoporosis Completed NCT00259857 Phase 2 Alendronate
4 Alendronate in Juvenile Osteoporosis Completed NCT00920075 Alendronate (Fosamax)
5 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

Anatomical Context for Idiopathic Juvenile Osteoporosis

MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

39
Bone, Testes, Skin

Publications for Idiopathic Juvenile Osteoporosis

Articles related to Idiopathic Juvenile Osteoporosis:

(show all 40)
id Title Authors Year
1
Idiopathic juvenile osteoporosis: A case report and review of the literature. ( 25768278 )
2015
2
Radiographic and MR Imaging Findings of the Spine after Bisphosphonate Treatment, in a Child with Idiopathic Juvenile Osteoporosis. ( 25688321 )
2015
3
Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes. ( 25783012 )
2015
4
Evidence of Altered Matrix Composition in Iliac Crest Biopsies from Patients with Idiopathic Juvenile Osteoporosis. ( 26539896 )
2015
5
Idiopathic Juvenile Osteoporosis: A Case Report. ( 26436063 )
2015
6
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. ( 23418950 )
2013
7
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. ( 23549954 )
2013
8
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. ( 16951909 )
2006
9
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. ( 12110417 )
2002
10
Idiopathic juvenile osteoporosis. ( 11973603 )
2002
11
Clinical evaluation of patients with idiopathic juvenile osteoporosis. ( 11497372 )
2001
12
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. ( 11496161 )
2001
13
Idiopathic juvenile osteoporosis. ( 10818429 )
2000
14
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. ( 11086654 )
2000
15
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. ( 10804027 )
2000
16
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. ( 9458225 )
1998
17
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. ( 8816205 )
1996
18
Idiopathic juvenile osteoporosis: experience of twenty-one patients. ( 7881843 )
1995
19
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. ( 7584708 )
1995
20
Idiopathic juvenile osteoporosis: five-year case follow-up. ( 7613264 )
1995
21
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. ( 7900745 )
1995
22
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? ( 7882130 )
1995
23
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. ( 8581446 )
1995
24
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. ( 7671570 )
1995
25
Idiopathic juvenile osteoporosis. ( 8434248 )
1993
26
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. ( 1393771 )
1992
27
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. ( 2012031 )
1991
28
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. ( 3177335 )
1988
29
Bone metabolism in idiopathic juvenile osteoporosis: a case report. ( 6839191 )
1983
30
Calcitriol deficiency in idiopathic juvenile osteoporosis. ( 6896958 )
1982
31
Idiopathic juvenile osteoporosis and scoliosis. ( 7130387 )
1982
32
Spinal deformity in idiopathic juvenile osteoporosis. ( 7209670 )
1981
33
Idiopathic juvenile osteoporosis. ( 6784514 )
1981
34
Idiopathic juvenile osteoporosis. ( 314235 )
1979
35
Idiopathic juvenile osteoporosis. ( 474538 )
1979
36
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. ( 891571 )
1977
37
Idiopathic juvenile osteoporosis. ( 5459928 )
1970
38
Idiopathic juvenile osteoporosis: report of a case and review of the literature. ( 4908113 )
1969
39
Idiopathic juvenile osteoporosis. ( 5363391 )
1969
40
IDIOPATHIC JUVENILE OSTEOPOROSIS. ( 14319616 )
1965

Variations for Idiopathic Juvenile Osteoporosis

Expression for Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for Idiopathic Juvenile Osteoporosis

Pathways related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 DKK1 LRP5 LRP6 WNT1 WNT3A
2
Show member pathways
12.38 DKK1 LRP5 LRP6 WNT1 WNT3A
3
Show member pathways
12.36 IGF1 LRP5 LRP6 WNT1 WNT3A
4
Show member pathways
12.32 IGF1 LRP5 LRP6 WNT1 WNT3A
5 12.23 DKK1 LRP5 LRP6 WNT1 WNT3A
6 12.12 IGF1 WNT1 WNT3A
7 12.11 DKK1 LRP5 LRP6 WNT3A
8 12.05 LRP5 LRP6 WNT1 WNT3A
9
Show member pathways
12.03 IGF1 LRP5 LRP6 WNT3A
10
Show member pathways
12 DKK1 LRP5 LRP6 WNT1 WNT3A
11
Show member pathways
11.96 IGF1 WNT1 WNT3A
12 11.94 IGF1 WNT1 WNT3A
13 11.91 DKK1 IGF1 WNT3A
14 11.82 DKK1 LRP5 LRP6 WNT1
15 11.79 COL1A1 IGF1 IGFBP3
16 11.74 BGLAP IGF1 IGFBP3
17 11.57 DKK1 LRP5 LRP6 WNT1
18 11.47 DKK1 IGF1 WNT3A
19 11.4 DKK1 LRP6 WNT1
20 11.3 DKK1 IGF1 WNT1 WNT3A
21 11.23 BGLAP COL1A1
22 11.21 BGLAP CALCA COL1A1 IGF1
23
Show member pathways
11.16 LRP5 LRP6 WNT3A
24 10.95 IGF1 IGFBP3
25 10.84 DKK1 LRP5 LRP6 WNT1
26 10.74 BGLAP COL1A1
27
Show member pathways
10.58 DKK1 LRP5 LRP6 WNT3A
28 10.47 DKK1 LRP5 LRP6 WNT1 WNT3A

GO Terms for Idiopathic Juvenile Osteoporosis

Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 BGLAP CALCA COL1A1 DKK1 GC IGF1
2 endoplasmic reticulum lumen GO:0005788 9.65 BGLAP COL1A1 IGFBP3 WNT1 WNT3A
3 extracellular region GO:0005576 9.65 BGLAP CALCA COL1A1 DKK1 GC IGF1
4 early endosome membrane GO:0031901 9.63 DKK1 LRP6 WNT3A
5 Golgi lumen GO:0005796 9.61 BGLAP WNT1 WNT3A
6 Wnt signalosome GO:1990909 9.4 LRP5 LRP6
7 insulin-like growth factor ternary complex GO:0042567 9.37 IGF1 IGFBP3
8 insulin-like growth factor binding protein complex GO:0016942 9.32 IGF1 IGFBP3
9 Wnt-Frizzled-LRP5/6 complex GO:1990851 8.8 LRP5 LRP6 WNT3A

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 IGF1 LRP5 WNT1 WNT3A
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 COL1A1 IGF1 LRP5 LRP6 WNT1 WNT3A
3 cellular protein metabolic process GO:0044267 9.84 CALCA IGF1 IGFBP3
4 skeletal system development GO:0001501 9.79 BGLAP COL1A1 IGF1
5 positive regulation of canonical Wnt signaling pathway GO:0090263 9.76 COL1A1 LRP6 WNT1 WNT3A
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.73 LRP5 LRP6 WNT1 WNT3A
7 bone development GO:0060348 9.72 BGLAP LRP5 WNT1
8 response to peptide hormone GO:0043434 9.71 COL1A1 LRP5 LRP6
9 osteoblast differentiation GO:0001649 9.71 BGLAP COL1A1 IGFBP3 WNT3A
10 midbrain development GO:0030901 9.67 WNT1 WNT3A
11 negative regulation of protein serine/threonine kinase activity GO:0071901 9.65 LRP5 LRP6
12 face morphogenesis GO:0060325 9.65 COL1A1 DKK1 LRP6
13 Wnt signaling pathway GO:0016055 9.65 DKK1 LRP5 LRP6 WNT1 WNT3A
14 positive regulation of mitotic nuclear division GO:0045840 9.64 IGF1 LRP5
15 vasculature development GO:0001944 9.64 CALCA LRP5
16 dopaminergic neuron differentiation GO:0071542 9.63 LRP6 WNT1
17 regulation of canonical Wnt signaling pathway GO:0060828 9.63 LRP5 LRP6
18 negative regulation of ossification GO:0030279 9.62 CALCA DKK1
19 canonical Wnt signaling pathway GO:0060070 9.62 LRP5 LRP6 WNT1 WNT3A
20 osteoblast development GO:0002076 9.61 BGLAP LRP5
21 negative regulation of cell-substrate adhesion GO:0010812 9.61 COL1A1 WNT1
22 spinal cord association neuron differentiation GO:0021527 9.6 WNT1 WNT3A
23 midbrain dopaminergic neuron differentiation GO:1904948 9.59 LRP6 WNT1
24 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.58 IGF1 LRP6
25 cell proliferation in midbrain GO:0033278 9.58 WNT1 WNT3A
26 Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 9.57 LRP5 LRP6
27 midbrain-hindbrain boundary development GO:0030917 9.56 LRP6 WNT1
28 Wnt signaling pathway involved in somitogenesis GO:0090244 9.52 DKK1 LRP6
29 axis elongation involved in somitogenesis GO:0090245 9.51 LRP6 WNT3A
30 positive regulation of dermatome development GO:0061184 9.49 WNT1 WNT3A
31 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.33 IGF1 IGFBP3 WNT1
32 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953 9.13 LRP6 WNT1 WNT3A
33 beta-catenin destruction complex disassembly GO:1904886 8.92 LRP5 LRP6 WNT1 WNT3A
34 multicellular organism development GO:0007275 10.06 DKK1 LRP5 LRP6 WNT1 WNT3A
35 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.05 IGF1 LRP5 LRP6 WNT1 WNT3A

Molecular functions related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.67 CALCA LRP6 WNT1 WNT3A
2 Wnt-protein binding GO:0017147 9.46 LRP5 LRP6
3 receptor agonist activity GO:0048018 9.43 WNT1 WNT3A
4 Wnt-activated receptor activity GO:0042813 9.4 LRP5 LRP6
5 frizzled binding GO:0005109 9.33 LRP6 WNT1 WNT3A
6 co-receptor binding GO:0039706 9.32 DKK1 WNT3A
7 toxin transporter activity GO:0019534 9.26 LRP5 LRP6
8 coreceptor activity involved in Wnt signaling pathway GO:0071936 8.96 LRP5 LRP6
9 coreceptor activity involved in canonical Wnt signaling pathway GO:1904928 8.62 LRP5 LRP6

Sources for Idiopathic Juvenile Osteoporosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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