IJO
MCID: IDP002
MIFTS: 45

Idiopathic Juvenile Osteoporosis (IJO) malady

Rare diseases, Bone diseases categories

Summaries for Idiopathic Juvenile Osteoporosis

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Looking for an antibody for researching idiopathic juvenile osteoporosis?

LRP5 antibody
CD36 antibody
CALCA antibody
BGLAP antibody
COL1A2 antibody
NIH Rare Diseases:42 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards based summary: Idiopathic Juvenile Osteoporosis, also known as idiopathic osteoporosis, is related to osteoporosis and ehlers-danlos syndrome. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds tiludronate and cyanogen bromide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related mouse phenotypes are behavior/neurological and skeleton.

Disease Ontology:9 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia:64 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Description from OMIM:46 259750

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

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Idiopathic Juvenile Osteoporosis, Aliases & Descriptions:

Name: Idiopathic Juvenile Osteoporosis 9 42 11 44 61
Idiopathic Osteoporosis 9 44 61
Juvenile Osteoporosis 9 42 61
 
Osteoporosis, Juvenile 42
Ijo 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:12559
OMIM46 259750
SNOMED-CT56 3345002
ICD9CM28 733.02
ICD1026 M80.5, M81.5

Related Diseases for Idiopathic Juvenile Osteoporosis

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Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.5LRP5, BGLAP, COL1A2, CALCA, CD36
2ehlers-danlos syndrome30.5CD36, COL1A2
3osteogenesis imperfecta30.0CD36, COL1A2, BGLAP, LRP5
4osteoporosis, early-onset autosomal dominant10.4
5reflex sympathetic dystrophy10.4CALCA
6paget's disease of bone10.3CALCA
7juvenile primary osteoporosis10.3
8osteitis fibrosa10.3BGLAP
9osteogenesis imperfecta type iii10.2COL1A2, CD36
10osteogenesis imperfecta, type ii10.2COL1A2, CD36
11osteogenesis imperfecta type 410.2COL1A2, CD36
12back pain10.2
13otosclerosis10.2CD36, COL1A2
14marfan syndrome10.2COL1A2, CD36
15dentinogenesis imperfecta10.2CD36, COL1A2
16connective tissue disease10.1CD36, COL1A2
17camurati-engelmann disease10.1LRP5, BGLAP
18glomerulosclerosis10.1CD36, COL1A2
19hyperostosis10.1LRP5, BGLAP
20osteofibrous dysplasia10.0BGLAP, CD36
21osteopetrosis10.0BGLAP, LRP5
22bone mineral density qtl18, osteoporosis10.0
23rickets10.0BGLAP, CD36
24pulmonary fibrosis10.0CD36, COL1A2
25bone cancer10.0CD36, BGLAP
26pseudohypoparathyroidism10.0BGLAP, CALCA
27hypoparathyroidism10.0BGLAP, CALCA
28hypophosphatemia10.0BGLAP, CALCA
29giant cell tumor10.0BGLAP, CALCA
30goiter10.0CALCA, BGLAP
31hyperparathyroidism9.9BGLAP, CALCA
32cushing's syndrome9.9BGLAP, CALCA
33hypercalcemia9.9BGLAP, CALCA
34hypogonadism9.9BGLAP, CALCA
35periodontal disease9.9BGLAP, CD36
36type 1 diabetes mellitus9.9LRP5, BGLAP
37primary hyperoxaluria9.9CALCA, BGLAP
38systemic scleroderma9.9CD36, COL1A2
39osteogenesis imperfecta type i9.8BGLAP, COL1A2, CD36
40short stature9.8CD36, COL1A2, BGLAP
41osteosarcoma9.8CD36, BGLAP, LRP5
42renal osteodystrophy9.8CD36, CALCA, BGLAP
43primary hyperparathyroidism9.8BGLAP, CALCA, CD36
44secondary hyperparathyroidism of renal origin9.8BGLAP, CALCA, CD36
45osteomalacia9.8BGLAP, CALCA, CD36
46thyroid hurthle cell carcinoma9.8BGLAP, CALCA
47osteoporosis, postmenopausal9.6LRP5, BGLAP, CALCA, CD36
48secondary syphilis9.6LRP5, BGLAP, CALCA, CD36
49diabetes mellitus9.6CD36, CALCA, BGLAP, LRP5
50osteoarthritis9.4CD36, CALCA, COL1A2, BGLAP, LRP5

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Symptoms for Idiopathic Juvenile Osteoporosis

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Clinical features from OMIM:

259750

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

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Drug clinical trials:

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Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

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Anatomical Context for Idiopathic Juvenile Osteoporosis

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MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

32
Bone, Skin, Testes

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

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MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4CD36, CALCA, COL1A2, LRP5
2MP:00053908.3CD36, CALCA, COL1A2, LRP5
3MP:00053858.1LRP5, COL1A2, CALCA, CD36

Publications for Idiopathic Juvenile Osteoporosis

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Articles related to Idiopathic Juvenile Osteoporosis:

(show all 35)
idTitleAuthorsYear
1
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
2
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
3
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
4
Idiopathic juvenile osteoporosis. (11973603)
2002
5
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
6
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
7
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
8
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
9
Idiopathic juvenile osteoporosis. (10818429)
2000
10
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
11
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
12
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
13
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
14
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
15
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
16
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
17
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
18
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
19
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
20
Idiopathic juvenile osteoporosis. (8434248)
1993
21
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
22
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
23
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
24
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
25
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
26
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
27
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
28
Idiopathic juvenile osteoporosis. (6784514)
1981
29
Idiopathic juvenile osteoporosis. (474538)
1979
30
Idiopathic juvenile osteoporosis. (314235)
1979
31
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
32
Idiopathic juvenile osteoporosis. (5459928)
1970
33
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
34
Idiopathic juvenile osteoporosis. (5363391)
1969
35
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Variations for Idiopathic Juvenile Osteoporosis

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Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

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Expression patterns in normal tissues for genes affiliated with Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

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Compounds for genes affiliated with Idiopathic Juvenile Osteoporosis

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Compounds related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1tiludronate44 50 1211.7CD36, CALCA
2cyanogen bromide449.7COL1A2, CD36
3silver nitrate449.7CD36, CALCA
4mithramycin449.6CALCA, COL1A2
5ti6al4v449.5CD36, BGLAP
622-oxacalcitriol449.5CD36, BGLAP
7alizarin449.5BGLAP, CD36
8polyglycolic acid449.4BGLAP, CD36
9calcium gluconate449.4BGLAP, CALCA
10ipriflavone449.4BGLAP, CALCA
11chitosan449.4CD36, BGLAP
12alfacalcidol44 60 1211.4CALCA, BGLAP
1324,25-dihydroxyvitamin d3449.4CALCA, BGLAP
14nandrolone decanoate44 1210.4CALCA, BGLAP
15titanium449.4CD36, BGLAP
16sodium fluoride449.3CALCA, BGLAP
17budesonide44 50 1211.3CD36, BGLAP
18thiazide449.3CALCA, BGLAP
19alginate449.3CD36, BGLAP
20tibolone449.3BGLAP, CALCA
21furosemide44 60 29 50 25 1214.1CALCA, BGLAP
22phosphorus449.1CALCA, BGLAP
23fluoride449.0BGLAP, CALCA
24captopril44 60 50 29 1213.0CD36, CALCA
25clonidine44 50 29 1212.0CALCA, BGLAP
26procollagen449.0CD36, COL1A2, BGLAP
27teriparatide44 1210.0BGLAP, CALCA, CD36
28etidronate449.0BGLAP, CALCA, CD36
291,25 dihydroxy vitamin d3449.0CALCA, BGLAP, LRP5
30ibandronate44 1210.0CD36, CALCA, BGLAP
31calcium carbonate449.0BGLAP, CALCA, CD36
32vitamin k2449.0CD36, CALCA, BGLAP
33tartrate448.9CD36, CALCA, BGLAP
34pamidronate44 50 1210.9BGLAP, CALCA, CD36
35risedronate44 50 29 60 1212.9CD36, CALCA, BGLAP
36clodronate44 50 1210.9CD36, CALCA, BGLAP
37pyridinoline448.9BGLAP, CALCA, CD36
38zoledronic acid448.9CD36, CALCA, BGLAP
39deoxypyridinoline448.9CD36, CALCA, BGLAP
40alendronate44 50 1210.9CD36, CALCA, BGLAP
4125-hydroxyvitamin d448.9BGLAP, CALCA, CD36
42raloxifene44 50 29 1211.9CD36, CALCA, BGLAP
43hydroxyproline44 25 1210.9BGLAP, CALCA, CD36
44hydrocortisone44 3 60 1211.9BGLAP, CALCA, CD36
45calcitriol44 60 25 1211.8CD36, CALCA, BGLAP
46pge2448.7BGLAP, CALCA, CD36
47creatinine448.4CD36, CALCA, BGLAP
48vitamin d448.0CD36, CALCA, COL1A2, BGLAP, LRP5
49estrogen447.9LRP5, BGLAP, COL1A2, CALCA, CD36
50calcium44 50 25 1210.9LRP5, BGLAP, COL1A2, CALCA, CD36

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

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Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CALCA, COL1A2, BGLAP

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.1COL1A2, BGLAP
2osteoblast developmentGO:0020769.1BGLAP, LRP5
3regulation of blood pressureGO:0082178.9CALCA, COL1A2, LRP5
4odontogenesisGO:0424768.8COL1A2, BGLAP

Products for genes affiliated with Idiopathic Juvenile Osteoporosis

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4CDC
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