IJO
MCID: IDP002
MIFTS: 45

Idiopathic Juvenile Osteoporosis (IJO) malady

Rare diseases, Bone diseases categories
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Summaries for Idiopathic Juvenile Osteoporosis

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards: Idiopathic Juvenile Osteoporosis, also known as idiopathic osteoporosis, is related to osteoporosis and osteogenesis imperfecta. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds tiludronate and cyanogen bromide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related mouse phenotypes are behavior/neurological and skeleton.

Disease Ontology:8 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia:65 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Description from OMIM:47 259750

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 47OMIM, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

idiopathic juvenile osteoporosis 8 43 10 45
idiopathic osteoporosis 8 45 62
juvenile osteoporosis 8 43 62
osteoporosis, juvenile 43
ijo 43


External Ids:

Disease Ontology8 DOID:12559
OMIM47 259750
SNOMED-CT58 3345002
ICD9CM27 733.02
ICD1025 M80.5, M81.5

Related Diseases for Idiopathic Juvenile Osteoporosis

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17GeneCards, 18GeneDecks
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Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis31.2LRP5, COL1A2, CD36, BGLAP, CALCA
2osteogenesis imperfecta30.4CD36, LRP5, BGLAP, COL1A2
3ehlers-danlos syndrome30.3COL1A2, CD36
4osteoporosis, early-onset autosomal dominant10.3
5juvenile primary osteoporosis10.2
6back pain10.2
7complex regional pain syndrome10.1CALCA
8paget's disease of bone10.1CALCA
9osteitis fibrosa10.1BGLAP
10osteogenesis imperfecta type iii10.0COL1A2, CD36
11osteogenesis imperfecta, type ii10.0CD36, COL1A2
12osteogenesis imperfecta type 410.0CD36, COL1A2
13otosclerosis10.0CD36, COL1A2
14marfan syndrome10.0CD36, COL1A2
15dentinogenesis imperfecta10.0COL1A2, CD36
16osteopenia - myopia - hearing loss - intellectual disability - facial dysmorphism10.0
17connective tissue disease10.0COL1A2, CD36
18camurati-engelmann disease10.0BGLAP, LRP5
19glomerulosclerosis10.0CD36, COL1A2
20hyperostosis10.0LRP5, BGLAP
21osteofibrous dysplasia10.0CD36, BGLAP
22osteopetrosis10.0BGLAP, LRP5
23bone mineral density qtl18, osteoporosis10.0
24rickets10.0CD36, BGLAP
25pulmonary fibrosis10.0COL1A2, CD36
26bone carcinoma10.0BGLAP, CD36
27pseudohypoparathyroidism10.0BGLAP, CALCA
28hypophosphatemia10.0BGLAP, CALCA
29hypoparathyroidism10.0BGLAP, CALCA
30giant cell tumor10.0CALCA, BGLAP
31goiter10.0CALCA, BGLAP
32hyperparathyroidism10.0CALCA, BGLAP
33hypercalcemia10.0BGLAP, CALCA
34cushing's syndrome10.0BGLAP, CALCA
35hypogonadism10.0BGLAP, CALCA
36periodontal disease10.0BGLAP, CD36
37type 1 diabetes mellitus10.0LRP5, BGLAP
38primary hyperoxaluria10.0CALCA, BGLAP
39systemic scleroderma10.0CD36, COL1A2
40osteogenesis imperfecta type i10.0BGLAP, CD36, COL1A2
41short stature10.0COL1A2, BGLAP, CD36
42osteosarcoma10.0LRP5, BGLAP, CD36
43renal osteodystrophy9.9CALCA, CD36, BGLAP
44primary hyperparathyroidism9.9CD36, CALCA, BGLAP
45secondary hyperparathyroidism of renal origin9.9BGLAP, CALCA, CD36
46osteomalacia9.9CALCA, CD36, BGLAP
47thyroid cancer9.9BGLAP, CALCA
48osteoporosis, postmenopausal9.9LRP5, CD36, BGLAP, CALCA
49secondary syphilis9.9BGLAP, CD36, CALCA, LRP5
50diabetes mellitus9.9CALCA, BGLAP, CD36, LRP5

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Symptoms for Idiopathic Juvenile Osteoporosis

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47OMIM
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Clinical features from OMIM:

259750

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Idiopathic Juvenile Osteoporosis

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

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Anatomical Context for Idiopathic Juvenile Osteoporosis

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33MalaCards
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MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

33
Bone, Skin, Testes

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4CD36, CALCA, COL1A2, LRP5
2MP:00053908.3CD36, CALCA, COL1A2, LRP5
3MP:00053858.1LRP5, COL1A2, CALCA, CD36

Publications for Idiopathic Juvenile Osteoporosis

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52PubMed
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Articles related to Idiopathic Juvenile Osteoporosis:

(show all 35)
idTitleAuthorsYear
1
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
2
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
3
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
4
Idiopathic juvenile osteoporosis. (11973603)
2002
5
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
6
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
7
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
8
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
9
Idiopathic juvenile osteoporosis. (10818429)
2000
10
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
11
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
12
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
13
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
14
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
15
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
16
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
17
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
18
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
19
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
20
Idiopathic juvenile osteoporosis. (8434248)
1993
21
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
22
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
23
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
24
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
25
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
26
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
27
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
28
Idiopathic juvenile osteoporosis. (6784514)
1981
29
Idiopathic juvenile osteoporosis. (474538)
1979
30
Idiopathic juvenile osteoporosis. (314235)
1979
31
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
32
Idiopathic juvenile osteoporosis. (5459928)
1970
33
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
34
Idiopathic juvenile osteoporosis. (5363391)
1969
35
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Variations for Idiopathic Juvenile Osteoporosis

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Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

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50PathCards, 55Reactome, 51PharmGKB, 38NCBI BioSystems Database, 60Thomson Reuters
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Compounds for genes affiliated with Idiopathic Juvenile Osteoporosis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1tiludronate45 51 1111.7CALCA, CD36
2cyanogen bromide459.7CD36, COL1A2
3silver nitrate459.7CALCA, CD36
4mithramycin459.6COL1A2, CALCA
5ti6al4v459.5CD36, BGLAP
622-oxacalcitriol459.5CD36, BGLAP
7alizarin459.5CD36, BGLAP
8polyglycolic acid459.4BGLAP, CD36
9ipriflavone459.4BGLAP, CALCA
10calcium gluconate459.4CALCA, BGLAP
11chitosan459.4CD36, BGLAP
12alfacalcidol45 61 1111.4CALCA, BGLAP
1324,25-dihydroxyvitamin d3459.4BGLAP, CALCA
14nandrolone decanoate45 1110.4BGLAP, CALCA
15titanium459.4CD36, BGLAP
16sodium fluoride459.3BGLAP, CALCA
17budesonide45 51 1111.3BGLAP, CD36
18thiazide459.3CALCA, BGLAP
19alginate459.3BGLAP, CD36
20tibolone459.3BGLAP, CALCA
21furosemide45 61 29 51 24 1114.1CALCA, BGLAP
22phosphorus459.1BGLAP, CALCA
23fluoride459.0CALCA, BGLAP
24captopril45 61 51 29 1113.0CD36, CALCA
25clonidine45 51 29 1112.0BGLAP, CALCA
26procollagen459.0COL1A2, BGLAP, CD36
27teriparatide45 1110.0BGLAP, CD36, CALCA
28etidronate459.0CALCA, BGLAP, CD36
291,25 dihydroxy vitamin d3459.0LRP5, CALCA, BGLAP
30ibandronate45 1110.0BGLAP, CD36, CALCA
31calcium carbonate459.0CD36, CALCA, BGLAP
32tartrate459.0CD36, CALCA, BGLAP
33vitamin k2458.9CD36, BGLAP, CALCA
34pamidronate45 51 1110.9BGLAP, CD36, CALCA
35risedronate45 51 29 61 1112.9CD36, BGLAP, CALCA
36clodronate45 51 1110.9CD36, CALCA, BGLAP
37pyridinoline458.9CALCA, CD36, BGLAP
38zoledronic acid458.9BGLAP, CALCA, CD36
39deoxypyridinoline458.9CD36, CALCA, BGLAP
40alendronate45 51 1110.9CD36, CALCA, BGLAP
4125-hydroxyvitamin d458.9BGLAP, CD36, CALCA
42raloxifene45 51 29 1111.9BGLAP, CALCA, CD36
43hydroxyproline45 24 1110.9CD36, CALCA, BGLAP
44hydrocortisone45 3 61 1111.9BGLAP, CALCA, CD36
45calcitriol45 61 24 1111.8CD36, BGLAP, CALCA
46pge2458.7BGLAP, CD36, CALCA
47creatinine458.4CD36, CALCA, BGLAP
48vitamin d458.0LRP5, CALCA, COL1A2, BGLAP, CD36
49estrogen457.9BGLAP, LRP5, COL1A2, CD36, CALCA
50calcium45 51 24 1110.9COL1A2, CD36, LRP5, BGLAP, CALCA

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

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16Gene Ontology
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Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CALCA, COL1A2, BGLAP

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.1COL1A2, BGLAP
2osteoblast developmentGO:0020769.1BGLAP, LRP5
3regulation of blood pressureGO:0082178.9CALCA, COL1A2, LRP5
4odontogenesisGO:0424768.8COL1A2, BGLAP

Products for genes affiliated with Idiopathic Juvenile Osteoporosis

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  • Antibodies
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Sources for Idiopathic Juvenile Osteoporosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet