MCID: IDP002
MIFTS: 48

Idiopathic Juvenile Osteoporosis malady

Categories: Rare diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

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Aliases & Descriptions for Idiopathic Juvenile Osteoporosis:

Name: Idiopathic Juvenile Osteoporosis 11 46 13 52 48
Juvenile Osteoporosis 11 46 52 66
Idiopathic Osteoporosis 11 48 66
 
Ijo 46 52
Osteoporosis, Juvenile 46

Characteristics:

Orphanet epidemiological data:

52
idiopathic juvenile osteoporosis:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood



Classifications:



External Ids:

Disease Ontology11 DOID:12559
ICD9CM30 733.02
Orphanet52 ORPHA85193
SNOMED-CT60 3345002
ICD10 via Orphanet29 M81.5
ICD1028 M80.5, M81.5

Summaries for Idiopathic Juvenile Osteoporosis

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NIH Rare Diseases:46 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures, difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.  last updated: 5/30/2012

MalaCards based summary: Idiopathic Juvenile Osteoporosis, also known as juvenile osteoporosis, is related to juvenile primary osteoporosis and osteoporosis, and has symptoms including bone pain, recurrent fractures and reduced bone mineral density. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (LDL Receptor Related Protein 5), and among its related pathways are Human Embryonic Stem Cell Pluripotency and Presenilin action in Notch and Wnt signaling. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Disease Ontology:11 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia:69 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Related Diseases for Idiopathic Juvenile Osteoporosis

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Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile primary osteoporosis11.1
2osteoporosis10.6
3papillary extrahepatic bile duct adenocarcinoma10.5CALCA, LRP5
4axial osteomalacia10.5LRP5, LRP6
5nodular goiter10.5BGLAP, CALCA
6scrotal carcinoma10.4BGLAP, CALCA
7brain injury10.4BGLAP, LRP5
8hypochondrogenesis10.4CALCA, PTH
9impotence10.4CALCA, PTH
10scapuloperoneal myopathy10.4LRP5, LRP6
11polyradiculopathy10.4CALCA, PTH
12lipodystrophy, familial partial, type 610.4BGLAP, LRP5
13achondrogenesis10.4BGLAP, PTH
14cranial nerve palsy10.3BGLAP, PTH
15weaver syndrome 110.3BGLAP, PTH
16hyper ige syndrome10.3LRP5, WNT3A
17anal buschke-lowenstein tumor10.3CALCA, PTH
18gestational diabetes10.3BGLAP, PTH
19sost-related sclerosing bone dysplasia10.3BGLAP, CALCA
20toenail dystrophy, isolated10.3CALCA, PTH
21obesity, severe bmiq910.3BGLAP, PTH
22mixed cell type adenoma of parathyroid10.2BGLAP, PTH
23parathyroid carcinoma10.2CALCA, PTH
24echolalia10.1BGLAP, PTH
25astrakhan spotted fever10.1CALCA, PTH
26parathyroid transitional clear cell adenoma10.1BGLAP, CALCA, PTH
27glycoproteinosis10.1BGLAP, CALCA, PTH
28capillariasis10.1BGLAP, CALCA, PTH
29angelucci's syndrome10.1BGLAP, CALCA, PTH
30acute salpingo-oophoritis10.1BGLAP, CALCA
31acquired hyperkeratosis10.1BGLAP, CALCA, PTH
32mild pre-eclampsia10.1BGLAP, CALCA, PTH
33allergic conjunctivitis10.1BGLAP, CALCA, PTH
34leukodystrophy10.1BGLAP, CALCA, PTH
35pseudobulbar palsy10.1BGLAP, CALCA, PTH
36interval angle-closure glaucoma10.0BGLAP, CALCA, PTH
37brain stem angioblastoma10.0BGLAP, CALCA, PTH
38mature cataract10.0BGLAP, COL1A2
39mental retardation, autosomal recessive 3510.0BGLAP, COL1A2
40osteogenesis imperfecta10.0
41commensal bacterial infectious disease10.0BGLAP, PTH
42ovarian insufficiency, familial10.0BGLAP, PTH
43osteogenesis imperfecta, type iii9.9COL1A2, WNT1
44scoliosis9.8
45ehlers-danlos syndrome9.8
46back pain9.8
47bone deterioration disease9.8BGLAP, CALCA, LRP5, PTH
48central nervous system hemangioma9.7CALCA, PTH
49osteogenesis imperfecta, type ii9.7BGLAP, COL1A2, WNT1
50bacillary angiomatosis9.6BGLAP, CALCA, DKK1, PTH

Comorbidity relations with Idiopathic Juvenile Osteoporosis via Phenotypic Disease Network (PDN):


Osteoporosis

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Symptoms for Idiopathic Juvenile Osteoporosis

About this section

Symptoms:

 52
  • osteoporosis
  • gait disturbance
  • bone pain
  • recurrent fractures
  • kyphosis
  • vertebral compression fractures

HPO human phenotypes related to Idiopathic Juvenile Osteoporosis:

(show all 7)
id Description Frequency HPO Source Accession
1 bone pain hallmark (90%) HP:0002653
2 recurrent fractures hallmark (90%) HP:0002757
3 reduced bone mineral density hallmark (90%) HP:0004349
4 gait disturbance typical (50%) HP:0001288
5 kyphosis occasional (7.5%) HP:0002808
6 osteoporosis HP:0000939
7 low serum calcitriol HP:0012052

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

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Drugs for Idiopathic Juvenile Osteoporosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AlendronatePhase 4, Phase 2, Phase 3157121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
2
PamidronatePhase 44440391-99-94674
Synonyms:
(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
(3-Amino-1-hydroxypropylidene)bisphosphonic acid
(3-Amino-1-hydroxypropylidene)diphosphonic acid
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
(3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate
(3-amino-1-hydroxypropylidene)-1,1-bisphosphonate
1-hydroxy-3-aminopropane-1,1-diphosphonic acid
3-Amino-1-hydroxypropylidene-1,1-diphosphonate
40391-99-9
57248-88-1
57248-88-1 (di-hydrochloride salt)
AC1L1IP4
AHPrBP
AKOS003599275
APD
Acide pamidronique
Acide pamidronique [INN-French]
Acido pamidronico
Acido pamidronico [INN-Spanish]
Acidum pamidronicum
Acidum pamidronicum [INN-Latin]
Amidronate
Aminomux
Aredia
BIDD:GT0538
Bisphosphonate 6
C019248
C07395
C3H11NO7P2
 
CHEMBL834
CID4674
ChemDiv1_025240
D07281
DB00282
EINECS 254-905-2
HMS2090C13
HMS658L06
HSCI1_000312
I14-2407
LS-174826
MolPort-002-131-054
NCGC00159433-02
NCGC00159433-03
Novartis brand of pamidronate disodium salt
PAMIDRONATE DISODIUM
PAMIDRONIC ACID
Pamidronate Disodium
Pamidronic acid
Pamidronic acid (INN)
Pamidronic acid [INN:BAN]
Ribodroat
Ribodroat (TN)
STOCK1N-12562
UNII-OYY3447OMC
amino-1-hydroxypropane-1,1-diphosphonate
aminohydroxypropylidene diphosphonate
aminopropanehydroxydiphosphonate
pamidronate
pamidronate calcium
pamidronate monosodium
3glucocorticoidsPhase 2, Phase 3, Phase 14756
4
MeloxicamPhase 37571125-38-75281106, 54677470
Synonyms:
(3E)-3-[hydroxy-[(5-methyl-1,3-thiazol-2-yl)amino]methylidene]-2-methyl-1,1-dioxo-1
133687-22-6
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methylthiazolyl)-, 1,1-dioxide
4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
4-hydroxy-2-mehtyl-N-(5-mehtyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
71125-38-7
AC-1325
AC1NQY12
AC1Q3XZW
AKOS000279442
Abbott brand of meloxicam
Almirall brand of meloxicam
Apo-meloxicam
Bio-0826
Boehringer Ingelheim brand of meloxicam
C065757
C08169
C14H13N3O4S2
CCRIS 9139
CHEMBL599
CID5281106
Co Meloxicam
D00969
DB00814
Dom-meloxicam
Europharma brand of meloxicam
FT-0082769
Gen-meloxicam
HMS1922D19
HMS2089B18
I06-0490
LS-40538
M1959
Masflex
 
Meloxicam
Meloxicam (JAN/USAN/INN)
Meloxicam [USAN:BAN:INN]
Meloxicamum
Meloxicamum [Latin]
Meloxicamum [latin]
Meloxivet
Metacam
Mobec
Mobic
Mobic (TN)
Mobic, Metacam, Parocin, Meloxicam
Mobicox
MolPort-002-885-839
Movalis
Movatec
Movicox
Méloxicam
Novo-meloxicam
PHL-meloxicam
PMS-meloxicam
Parocin
Promeco brand of meloxicam
Ratio-meloxicam
S1734_Selleck
SPECTRUM1504150
STK620505
Squibb brand of meloxicam
TL8005001
Tenaron
UH-AC 62XX
UHAC-62XX
UNII-VG2QF83CGL
UNII-vg2qf83cgl
Uticox
meloxicam
miloxicam
reumoxicam
5
NaproxenPhase 324822204-53-11302, 156391
Synonyms:
(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-(S)-Naproxen
(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionsaeure
(+)-2-(Methoxy-2-naphthyl)-propionsaeure [German]
(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-Naproxen
(+)NAPROXEN
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
(S)-()-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-()-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-(+)-Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
(S)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-Naproxen
2-(6-Methoxy-2-naphthyl)propionic acid
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)- (8CI)
22204-53-1
284785_ALDRICH
46482_FLUKA
46482_RIEDEL
65126_FLUKA
AC-1363
AC1L4G3X
AC1Q4ET9
AC1Q4F4H
AC1Q4F4I
ARONIS24306
Acusprain
Aleve
Anaprox
Anax
Anexopen
Apo-Napro-NA
Apo-Naproxen
Apronax
Artagen
Arthrisil
Artrixen
Artroxen
Atiflan
Axer
BIDD:GT0062
BRD-K59197931-001-02-9
BRD-K59197931-236-09-6
BSPBio_002067
Bipronyl
Bonyl
CAS-22204-53-1
CCRIS 5265
CG 3117
CHEBI:7476
CHEMBL154
CID156391
Calosen
Clinosyn
Congex
D-Naproxen
DB08298
DL Naproxen
DL-Naproxen
Danaprox
Daprox
Diocodal
DivK1c_000242
Duk
Dysmenalgit
Dysmenalgit N
EINECS 244-838-7
Ec-Naprosyn
Equiproxen
Equiproxen (Veterinary)
FT-0082415
Flanax Forte
Flexen
Flexipen
Floginax
Fuxen
Genoxen
HMS1920P13
HMS2089N21
HMS2091H12
HMS500M04
HSDB 3369
Headlon
IDI1_000242
InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
KBio1_000242
KBio2_001457
KBio2_004025
KBio2_006593
KBio3_001567
KBioGR_000597
KBioSS_001457
LS-124738
Laraflex
 
Lefaine
Leniartil
Lopac0_000792
M1021
Methoxypropiocin
MolPort-000-145-960
N8280_SIAL
NAPROXEN
NCGC00016759-01
NCGC00021127-01
NCGC00161591-01
NINDS_000242
NPS
Nafasol
Naixan
Nalyxan
Napflam
Napmel
Naposin
Napratec
Naprelan
Napren
Napren E
Naprius
Naprolag
Naprontag
Naprosin
Naprosyn LLE
Naprosyn LLE Forte
Naprosyne
Naproxen
Naproxen Sodium
Naproxen [USAN:BAN:INN:JAN]
Naproxene
Naproxene [INN-French]
Naproxeno
Naproxeno [INN-Spanish]
Naproxenum
Naproxenum [INN-Latin]
Naproxi 250
Naproxi 500
Naproxène
Napxen
Narma
Narocin
Naxen
Naxen F
Naxopren
Naxyn
Naxyn 250
Naxyn 500
Noflam
Novonaprox
Nycopren
Opipramol
Patxen
Prafena
Prestwick0_000791
Prestwick1_000791
Prestwick2_000791
Prestwick_349
Prexan
Priaxen
Pronaxen
Proxen LE
Proxen LLE
RS 3540
RS-3540
Rahsen
Reuxen
Rheumaflex
Roxen
SPBio_000966
SPBio_002861
SPECTRUM1500425
SR-01000075977-3
STOCK1N-50633
Saritilron
Sinartrin
Sinton
Soproxen
Spectrum2_001043
Spectrum3_000514
Spectrum4_000069
Spectrum5_001327
Spectrum_000977
Sutolin
Sutony
TL8003659
Tohexen
Traumox
U-Ritis
UNII-57Y76R9ATQ
UPCMLD-DP001
UPCMLD-DP001:001
Velsay
Veradol
Vinsen
Xenar
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure
d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure [German]
d-2-(6-Methoxy-2-naphthyl)propionic acid
d-Naproxen
6
SerotoninPhase 3351050-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
7
NorepinephrinePhase 366451-41-2439260
Synonyms:
(-)-(R)-Norepinephrine
(-)-Arterenol
(-)-Arterenol free base
(-)-NORADRENALINE
(-)-Noradrenaline
(-)-Norepinephrine
(-)-alpha-(Aminomethyl)protocatechuyl alcohol
(R)-(-)-Norepinephrine
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
(R)-Noradrenaline
(R)-Norepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI)
4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
4899-05-2
51-40-1 (l-tartrate (1:1))
51-41-2
66197-73-7
A7257_SIGMA
AC1L96ZT
ALBB-006229
Adrenor
Aktamin
Arterenol
BRN 4231961
BSPBio_002079
C00547
CHEBI:18357
CHEMBL1437
CID439260
D-(-)-Noradrenaline
D00076
D53D5E3A-2360-4CA9-8031-6C2CD4062FD5
DB00368
DivK1c_000230
EINECS 200-096-6
HMS1920B08
HMS2089E18
HMS2091J08
HMS500L12
IDI1_000230
KBio1_000230
KBio2_001489
KBio2_004057
KBio2_006625
KBio3_001579
KBioGR_000635
KBioSS_001489
L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
L-3,4-Dihydroxyphenylethanolamine
L-3,4-dihydroxyphenylethanolamine
L-Arterenol
L-Noradrenaline
L-Norepinephrine
L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol
L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol
L-arterenol
L-noradrenaline
LS-42676
LT03330026
 
LT4
Levarterenol
Levarterenolo
Levarterenolo [DCIT]
Levoarterenol
Levonor
Levonoradrenaline
Levonorepinephrine
Levophed
NCGC00159406-02
NCGC00159406-03
NCGC00159406-04
NCGC00159406-05
NCGC00159406-06
NCGC00159406-07
NCGC00159406-09
NINDS_000230
Nor adrenalin
Nor adrenalin (TN)
Nor-Epirenan
Nor-adrenaline
Noradrenalin
Noradrenalina
Noradrenalina [Italian]
Noradrenaline
Noradrenaline (JP15)
Noradrenalinum
Norartrinal
Noreinefrina
Noreinefrina [INN-Spanish]
Norepinefrina
Norepinephrine
Norepinephrine (INN)
Norepinephrine Noradrenalin
Norepinephrine [INN:JAN]
Norepinephrine l-Tartrate (1:1)
Norepinephrinum
Norepinephrinum [INN-Latin]
Norepirenamine
PDSP1_001111
PDSP2_001095
SGCUT00123
SPBio_001048
SPECTRUM1500436
STK503776
Spectrum2_001064
Spectrum3_000520
Spectrum4_000078
Spectrum5_001068
Spectrum_001009
Sympathin E
UNII-X4W3ENH1CV
bmse000404
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol
l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
nchembio.284-comp2
nchembio.64-comp2
nchembio705-1
noradrenaline
norepinefrina
norepinephrine
norepinephrinum
to_000024
8
DopaminePhase 3367851-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
9insulinPhase 34401
10vitamin dPhase 21607
11
Calcium carbonatePhase 2202471-34-1
Synonyms:
CaCO3
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
 
Carbonato de calcio
Carbonic acid calcium salt (1:1)
E 170
Kalziumkarbonat
Kohlensaurer kalk
Precipitated calcium carbonate
12
DenosumabPhase 1, Phase 2126615258-40-7
Synonyms:
615258-40-7
AMG-162
D03684
Denosumab
 
Denosumab (USAN)
Denosumab (genetical recombination)
Denosumab (genetical recombination) (JAN)
Prolia
Xgeva
13
CholecalciferolNutraceuticalPhase 282667-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
 
Colecalciferol
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
calciol
cholecalciferol
delta-D
vitamin d-3
14
ErgocalciferolNutraceuticalPhase 2121150-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Bisphosphonate Therapy for Osteogenesis ImperfectaCompletedNCT00159419Phase 4
2Meloxicam [Mobic] in Juvenile Rheumatoid Arthritis (JRA)CompletedNCT00034853Phase 3
3A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia SyndromeRecruitingNCT01237587Phase 3
4Alendronate Osteoporosis StudyActive, not recruitingNCT00277251Phase 2, Phase 3
5A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (USA)- DIAPREVENTTerminatedNCT00751842Phase 3
6Phase II Study of Alendronate Sodium in Children With High-Turnover Idiopathic Juvenile OsteoporosisCompletedNCT00010439Phase 2
7Treatment of Childhood Osteoporosis With Alendronate (Fosamax)CompletedNCT00001720Phase 2
8Safety and Efficacy of Alendronate (Fosamax) in Children With OsteoporosisCompletedNCT00259857Phase 2
9Denosumab for Glucocorticoid-treated Children With Rheumatic DisordersNot yet recruitingNCT02418273Phase 1, Phase 2
10Alendronate in Juvenile OsteoporosisCompletedNCT00920075
11The Influence of Bisphosphonates in the Oral Cavity in ChildrenCompletedNCT00402064
12Rheumatology Clinical RegistryRecruitingNCT01813409
13Spine Quantitative Computed Tomography (QCT)Active, not recruitingNCT00762879
14Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence StudyActive, not recruitingNCT01663129

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

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Anatomical Context for Idiopathic Juvenile Osteoporosis

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MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

34
Bone, Testes, Skin

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

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MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.3DKK1, LRP5, LRP6, PTH, WNT1, WNT3A
2MP:00053717.4COL1A2, DKK1, LRP5, LRP6, PTH, WNT3A
3MP:00053906.7COL1A2, DKK1, LRP5, LRP6, PLS3, PTH

Publications for Idiopathic Juvenile Osteoporosis

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Articles related to Idiopathic Juvenile Osteoporosis:

(show all 40)
idTitleAuthorsYear
1
Radiographic and MR Imaging Findings of the Spine after Bisphosphonate Treatment, in a Child with Idiopathic Juvenile Osteoporosis. (25688321)
2015
2
Idiopathic juvenile osteoporosis: A case report and review of the literature. (25768278)
2015
3
Evidence of Altered Matrix Composition in Iliac Crest Biopsies from Patients with Idiopathic Juvenile Osteoporosis. (26539896)
2015
4
Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes. (25783012)
2015
5
Idiopathic Juvenile Osteoporosis: A Case Report. (26436063)
2015
6
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
7
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
8
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
9
Idiopathic juvenile osteoporosis. (11973603)
2002
10
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
11
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
12
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
13
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
14
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
15
Idiopathic juvenile osteoporosis. (10818429)
2000
16
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
17
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
18
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
19
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
20
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
21
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
22
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
23
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
24
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
25
Idiopathic juvenile osteoporosis. (8434248)
1993
26
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
27
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
28
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
29
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
30
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
31
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
32
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
33
Idiopathic juvenile osteoporosis. (6784514)
1981
34
Idiopathic juvenile osteoporosis. (474538)
1979
35
Idiopathic juvenile osteoporosis. (314235)
1979
36
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
37
Idiopathic juvenile osteoporosis. (5459928)
1970
38
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
39
Idiopathic juvenile osteoporosis. (5363391)
1969
40
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Variations for Idiopathic Juvenile Osteoporosis

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Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

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Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section

Pathways related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4DKK1, WNT1, WNT3A
29.4DKK1, LRP6, WNT1
39.3LRP5, LRP6, WNT3A
4
Show member pathways
9.3LRP5, LRP6, WNT3A
59.1BGLAP, COL1A2
69.1DKK1, LRP5, LRP6, WNT1
79.0LRP5, LRP6, WNT1, WNT3A
8
Show member pathways
9.0LRP5, LRP6, WNT1, WNT3A
99.0BGLAP, CALCA, PTH
10
Show member pathways
9.0DKK1, LRP5, LRP6, WNT3A
11
Show member pathways
9.0DKK1, LRP5, LRP6, WNT3A
129.0DKK1, LRP5, LRP6, WNT3A
13
Show member pathways
8.8CALCA, PTH, WNT1, WNT3A
148.7DKK1, LRP5, LRP6, WNT1, WNT3A
15
Show member pathways
8.7DKK1, LRP5, LRP6, WNT1, WNT3A
168.7DKK1, LRP5, LRP6, WNT1, WNT3A
17
Show member pathways
8.7DKK1, LRP5, LRP6, WNT1, WNT3A
18
Show member pathways
8.7DKK1, LRP5, LRP6, WNT1, WNT3A
19
Show member pathways
8.7DKK1, LRP5, LRP6, WNT1, WNT3A
208.6BGLAP, COL1A2, PTH

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

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Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Wnt signalosomeGO:199090910.3LRP5, LRP6
2Wnt-Frizzled-LRP5/6 complexGO:199085110.0LRP5, LRP6, WNT3A
3Golgi lumenGO:00057969.7BGLAP, WNT1, WNT3A
4early endosome membraneGO:00319019.6DKK1, LRP6, WNT3A
5endoplasmic reticulum lumenGO:00057888.6BGLAP, COL1A2, WNT1, WNT3A
6extracellular spaceGO:00056157.2BGLAP, CALCA, COL1A2, DKK1, PTH, WNT1
7extracellular regionGO:00055766.4BGLAP, CALCA, COL1A2, DKK1, LRP6, PTH

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1cell proliferation in midbrainGO:003327810.4WNT1, WNT3A
2Wnt signaling pathway involved in dorsal/ventral axis specificationGO:004433210.4LRP5, LRP6
3positive regulation of dermatome developmentGO:006118410.4WNT1, WNT3A
4spinal cord association neuron differentiationGO:002152710.4WNT1, WNT3A
5midbrain-hindbrain boundary developmentGO:003091710.4LRP6, WNT1
6axis elongation involved in somitogenesisGO:009024510.3LRP6, WNT3A
7negative regulation of fat cell differentiationGO:004559910.2WNT1, WNT3A
8osteoblast developmentGO:000207610.2BGLAP, LRP5
9negative regulation of BMP signaling pathwayGO:003051410.2DKK1, WNT1
10negative regulation of protein serine/threonine kinase activityGO:007190110.2LRP5, LRP6
11midbrain dopaminergic neuron differentiationGO:190494810.2LRP6, WNT1
12positive regulation of ossificationGO:004577810.2CALCA, PTH
13midbrain developmentGO:003090110.1WNT1, WNT3A
14dopaminergic neuron differentiationGO:007154210.1LRP6, WNT1
15Wnt signaling pathway involved in somitogenesisGO:009024410.1DKK1, LRP6
16Wnt signaling pathway involved in midbrain dopaminergic neuron differentiationGO:190495310.0LRP6, WNT1, WNT3A
17face morphogenesisGO:006032510.0DKK1, LRP6
18response to vitamin DGO:00332809.8BGLAP, PTH
19odontogenesisGO:00424769.7BGLAP, COL1A2
20Rho protein signal transductionGO:00072669.6COL1A2, PTH
21positive regulation of canonical Wnt signaling pathwayGO:00902639.6LRP6, WNT1, WNT3A
22adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.5CALCA, PTH
23beta-catenin destruction complex disassemblyGO:19048869.5LRP5, LRP6, WNT1, WNT3A
24positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4LRP5, LRP6, WNT1, WNT3A
25canonical Wnt signaling pathwayGO:00600709.3LRP5, LRP6, WNT1, WNT3A
26positive regulation of transcription, DNA-templatedGO:00458939.3LRP5, LRP6, WNT1, WNT3A
27bone developmentGO:00603489.3BGLAP, LRP5, PLS3, WNT1
28Wnt signaling pathwayGO:00160559.0LRP5, LRP6, WNT1, WNT3A
29skeletal system developmentGO:00015018.8BGLAP, COL1A2, PTH
30positive regulation of transcription from RNA polymerase II promoterGO:00459448.2LRP5, LRP6, PTH, WNT1, WNT3A

Molecular functions related to Idiopathic Juvenile Osteoporosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1coreceptor activity involved in canonical Wnt signaling pathwayGO:190492810.2LRP5, LRP6
2coreceptor activity involved in Wnt signaling pathwayGO:007193610.2LRP5, LRP6
3toxin transporter activityGO:001953410.2LRP5, LRP6
4Wnt-activated receptor activityGO:004281310.2LRP5, LRP6
5Wnt-protein bindingGO:00171479.8LRP5, LRP6
6co-receptor bindingGO:00397069.8DKK1, WNT3A
7receptor agonist activityGO:00480189.7WNT1, WNT3A
8frizzled bindingGO:00051099.3LRP6, WNT1, WNT3A

Sources for Idiopathic Juvenile Osteoporosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
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30ICD9CM
31IUPHAR
32KEGG
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38MESH via Orphanet
39MGI
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44NDF-RT
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