IJO
MCID: IDP002
MIFTS: 45

Idiopathic Juvenile Osteoporosis (IJO) malady

Rare diseases, Bone diseases categories

Summaries for Idiopathic Juvenile Osteoporosis

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Juvenile osteoporosis is a condition of bone demineralization characterized by pain in the back and extremities, multiple fractures,Ā difficulty walking, and evidence of osteoporosis. symptoms typically develop just before puberty. osteoporosis is rare in children and adolescents. when it does occur, it is usually caused by an underlying medical disorder or by medications used to treat the disorder. this is called secondary osteoporosis. sometimes, however, there is no identifiable cause of osteoporosis in a child. this is known as idiopathic osteoporosis. there is no established medical or surgical therapy for juvenile osteoporosis. in some cases, treatment is not necessary, as the condition resolves spontaneously. early diagnosis may allow for preventive steps, including physical therapy, avoidance of weight-bearing activities, use of crutches and other supportive care. a well-balanced diet rich in calcium and vitamin d is also important. in severe, long-lasting cases, medications such as bisphosphonates may be used. in most cases, complete recovery of bone occurs.Ā  last updated: 5/30/2012

MalaCards: Idiopathic Juvenile Osteoporosis, also known as idiopathic osteoporosis, is related to osteoporosis and osteogenesis imperfecta. An important gene associated with Idiopathic Juvenile Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds tiludronate and cyanogen bromide have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related mouse phenotypes are behavior/neurological and skeleton.

Disease Ontology:9 An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Wikipedia:66 Juvenile osteoporosis is osteoporosis in children and adolescents. more...

Description from OMIM:48 259750

Aliases & Classifications for Idiopathic Juvenile Osteoporosis

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 48OMIM, 28ICD9CM, 59SNOMED-CT, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

idiopathic juvenile osteoporosis 9 44 11 46
idiopathic osteoporosis 9 46 63
juvenile osteoporosis 9 44 63
osteoporosis, juvenile 44
ijo 44


External Ids:

Disease Ontology9 DOID:12559
OMIM48 259750
SNOMED-CT59 3345002
ICD9CM28 733.02
ICD1026 M80.5, M81.5

Related Diseases for Idiopathic Juvenile Osteoporosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Idiopathic Juvenile Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis31.2LRP5, COL1A2, CD36, BGLAP, CALCA
2osteogenesis imperfecta30.4CD36, LRP5, BGLAP, COL1A2
3ehlers-danlos syndrome30.3COL1A2, CD36
4osteoporosis, early-onset autosomal dominant10.3
5juvenile primary osteoporosis10.2
6back pain10.2
7complex regional pain syndrome10.1CALCA
8paget's disease of bone10.1CALCA
9osteitis fibrosa10.1BGLAP
10osteogenesis imperfecta type iii10.0COL1A2, CD36
11osteogenesis imperfecta, type ii10.0CD36, COL1A2
12osteogenesis imperfecta type 410.0CD36, COL1A2
13otosclerosis10.0CD36, COL1A2
14marfan syndrome10.0CD36, COL1A2
15dentinogenesis imperfecta10.0COL1A2, CD36
16osteopenia - myopia - hearing loss - intellectual disability - facial dysmorphism10.0
17connective tissue disease10.0COL1A2, CD36
18camurati-engelmann disease10.0BGLAP, LRP5
19glomerulosclerosis10.0CD36, COL1A2
20hyperostosis10.0LRP5, BGLAP
21osteofibrous dysplasia10.0CD36, BGLAP
22osteopetrosis10.0BGLAP, LRP5
23bone mineral density qtl18, osteoporosis10.0
24rickets10.0CD36, BGLAP
25pulmonary fibrosis10.0COL1A2, CD36
26bone carcinoma10.0BGLAP, CD36
27pseudohypoparathyroidism10.0BGLAP, CALCA
28hypophosphatemia10.0BGLAP, CALCA
29hypoparathyroidism10.0BGLAP, CALCA
30giant cell tumor10.0CALCA, BGLAP
31goiter10.0CALCA, BGLAP
32hyperparathyroidism10.0CALCA, BGLAP
33hypercalcemia10.0BGLAP, CALCA
34cushing's syndrome10.0BGLAP, CALCA
35hypogonadism10.0BGLAP, CALCA
36periodontal disease10.0BGLAP, CD36
37type 1 diabetes mellitus10.0LRP5, BGLAP
38primary hyperoxaluria10.0CALCA, BGLAP
39systemic scleroderma10.0CD36, COL1A2
40osteogenesis imperfecta type i10.0BGLAP, CD36, COL1A2
41short stature10.0COL1A2, BGLAP, CD36
42osteosarcoma10.0LRP5, BGLAP, CD36
43renal osteodystrophy9.9CALCA, CD36, BGLAP
44primary hyperparathyroidism9.9CD36, CALCA, BGLAP
45secondary hyperparathyroidism of renal origin9.9BGLAP, CALCA, CD36
46osteomalacia9.9CALCA, CD36, BGLAP
47thyroid cancer9.9BGLAP, CALCA
48osteoporosis, postmenopausal9.9LRP5, CD36, BGLAP, CALCA
49secondary syphilis9.9BGLAP, CD36, CALCA, LRP5
50diabetes mellitus9.9CALCA, BGLAP, CD36, LRP5

Graphical network of the top 20 diseases related to Idiopathic Juvenile Osteoporosis:



Diseases related to idiopathic juvenile osteoporosis

Symptoms for Idiopathic Juvenile Osteoporosis

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

259750

Drugs & Therapeutics for Idiopathic Juvenile Osteoporosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Idiopathic Juvenile Osteoporosis

Search NIH Clinical Center for Idiopathic Juvenile Osteoporosis

Search CenterWatch for Idiopathic Juvenile Osteoporosis

Genetic Tests for Idiopathic Juvenile Osteoporosis

About this section

Anatomical Context for Idiopathic Juvenile Osteoporosis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Idiopathic Juvenile Osteoporosis:

34
Bone, Skin, Testes

Animal Models for Idiopathic Juvenile Osteoporosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Idiopathic Juvenile Osteoporosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4CD36, CALCA, COL1A2, LRP5
2MP:00053908.3CD36, CALCA, COL1A2, LRP5
3MP:00053858.1LRP5, COL1A2, CALCA, CD36

Publications for Idiopathic Juvenile Osteoporosis

About this section
Sources:
53PubMed
See all sources

Articles related to Idiopathic Juvenile Osteoporosis:

(show all 35)
idTitleAuthorsYear
1
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography. (23418950)
2013
2
Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. (23549954)
2013
3
Idiopathic juvenile osteoporosis--an analysis of the muscle-bone relationship. (16951909)
2006
4
Idiopathic juvenile osteoporosis. (11973603)
2002
5
The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. (12110417)
2002
6
Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. (11496161)
2001
7
Clinical evaluation of patients with idiopathic juvenile osteoporosis. (11497372)
2001
8
Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. (11086654)
2000
9
Idiopathic juvenile osteoporosis. (10818429)
2000
10
Deficient bone formation in idiopathic juvenile osteoporosis: a histomorphometric study of cancellous iliac bone. (10804027)
2000
11
Difficulty walking. A presentation of idiopathic juvenile osteoporosis. (9458225)
1998
12
Collagen peptides in osteogenesis imperfecta, idiopathic juvenile osteoporosis and Ehlers--Danlos syndrome. (8816205)
1996
13
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
14
Idiopathic juvenile osteoporosis: five-year case follow-up. (7613264)
1995
15
Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis. (7584708)
1995
16
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
17
Fracture of the humerus in ball throwers. A consequence of idiopathic juvenile osteoporosis in a female handball player? (7882130)
1995
18
Case report: effect of pregnancy on idiopathic juvenile osteoporosis. (7900745)
1995
19
Idiopathic juvenile osteoporosis: experience of twenty-one patients. (7881843)
1995
20
Idiopathic juvenile osteoporosis. (8434248)
1993
21
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test. (1393771)
1992
22
Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis. (2012031)
1991
23
Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis. (3177335)
1988
24
Bone metabolism in idiopathic juvenile osteoporosis: a case report. (6839191)
1983
25
Idiopathic juvenile osteoporosis and scoliosis. (7130387)
1982
26
Calcitriol deficiency in idiopathic juvenile osteoporosis. (6896958)
1982
27
Spinal deformity in idiopathic juvenile osteoporosis. (7209670)
1981
28
Idiopathic juvenile osteoporosis. (6784514)
1981
29
Idiopathic juvenile osteoporosis. (474538)
1979
30
Idiopathic juvenile osteoporosis. (314235)
1979
31
A case-report of idiopathic juvenile osteoporosis with particular reference to 47-calcium absorption. (891571)
1977
32
Idiopathic juvenile osteoporosis. (5459928)
1970
33
Idiopathic juvenile osteoporosis: report of a case and review of the literature. (4908113)
1969
34
Idiopathic juvenile osteoporosis. (5363391)
1969
35
IDIOPATHIC JUVENILE OSTEOPOROSIS. (14319616)
1965

Variations for Idiopathic Juvenile Osteoporosis

About this section

Expression for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Idiopathic Juvenile Osteoporosis

Search GEO for disease gene expression data for Idiopathic Juvenile Osteoporosis.

Pathways for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section
Sources:
51PathCards, 56Reactome, 52PharmGKB, 39NCBI BioSystems Database, 61Thomson Reuters
See all sources

Compounds for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
See all sources

Compounds related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1tiludronate46 52 1211.7CALCA, CD36
2cyanogen bromide469.7CD36, COL1A2
3silver nitrate469.7CALCA, CD36
4mithramycin469.6COL1A2, CALCA
5ti6al4v469.5CD36, BGLAP
622-oxacalcitriol469.5CD36, BGLAP
7alizarin469.5CD36, BGLAP
8polyglycolic acid469.4BGLAP, CD36
9ipriflavone469.4BGLAP, CALCA
10calcium gluconate469.4CALCA, BGLAP
11chitosan469.4CD36, BGLAP
12alfacalcidol46 62 1211.4CALCA, BGLAP
1324,25-dihydroxyvitamin d3469.4BGLAP, CALCA
14nandrolone decanoate46 1210.4BGLAP, CALCA
15titanium469.4CD36, BGLAP
16sodium fluoride469.3BGLAP, CALCA
17budesonide46 52 1211.3BGLAP, CD36
18thiazide469.3CALCA, BGLAP
19alginate469.3BGLAP, CD36
20tibolone469.3BGLAP, CALCA
21furosemide46 62 30 52 25 1214.1CALCA, BGLAP
22phosphorus469.1BGLAP, CALCA
23fluoride469.0CALCA, BGLAP
24captopril46 62 52 30 1213.0CD36, CALCA
25clonidine46 52 30 1212.0BGLAP, CALCA
26procollagen469.0COL1A2, BGLAP, CD36
27teriparatide46 1210.0BGLAP, CD36, CALCA
28etidronate469.0CALCA, BGLAP, CD36
291,25 dihydroxy vitamin d3469.0LRP5, CALCA, BGLAP
30ibandronate46 1210.0BGLAP, CD36, CALCA
31calcium carbonate469.0CD36, CALCA, BGLAP
32tartrate469.0CD36, CALCA, BGLAP
33vitamin k2468.9CD36, BGLAP, CALCA
34pamidronate46 52 1210.9BGLAP, CD36, CALCA
35risedronate46 52 30 62 1212.9CD36, BGLAP, CALCA
36clodronate46 52 1210.9CD36, CALCA, BGLAP
37pyridinoline468.9CALCA, CD36, BGLAP
38zoledronic acid468.9BGLAP, CALCA, CD36
39deoxypyridinoline468.9CD36, CALCA, BGLAP
40alendronate46 52 1210.9CD36, CALCA, BGLAP
4125-hydroxyvitamin d468.9BGLAP, CD36, CALCA
42raloxifene46 52 30 1211.9BGLAP, CALCA, CD36
43hydroxyproline46 25 1210.9CD36, CALCA, BGLAP
44hydrocortisone46 3 62 1211.9BGLAP, CALCA, CD36
45calcitriol46 62 25 1211.8CD36, BGLAP, CALCA
46pge2468.7BGLAP, CD36, CALCA
47creatinine468.4CD36, CALCA, BGLAP
48vitamin d468.0LRP5, CALCA, COL1A2, BGLAP, CD36
49estrogen467.9BGLAP, LRP5, COL1A2, CD36, CALCA
50calcium46 52 25 1210.9COL1A2, CD36, LRP5, BGLAP, CALCA

GO Terms for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5CALCA, COL1A2, BGLAP

Biological processes related to Idiopathic Juvenile Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.1COL1A2, BGLAP
2osteoblast developmentGO:0020769.1BGLAP, LRP5
3regulation of blood pressureGO:0082178.9CALCA, COL1A2, LRP5
4odontogenesisGO:0424768.8COL1A2, BGLAP

Products for genes affiliated with Idiopathic Juvenile Osteoporosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Idiopathic Juvenile Osteoporosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet