MCID: IDP064
MIFTS: 45

Idiopathic Neutropenia malady

Categories: Rare diseases

Aliases & Classifications for Idiopathic Neutropenia

Aliases & Descriptions for Idiopathic Neutropenia:

Name: Idiopathic Neutropenia 50 69
Nonimmune Chronic Idiopathic Neutropenia of Adults 50 24
Neutropenia, Nonimmune Chronic Idiopathic, of Adults 24
Neutropenia, Nonimmune Chronic Idiopathic, Adult 69
Ni-Cina 50

Classifications:



Summaries for Idiopathic Neutropenia

NIH Rare Diseases : 50 idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown. neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils, a type of white blood cell that is responsible for much of the body's protection against infection. symptoms include fever, moth sores, and other types of infections. neutropenia idiopathic may occur in children and adults. frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections. most patients respond well to granulocyte-colony stimulating factor (g-csf). long-term treatment is usually required.   last updated: 1/13/2014

MalaCards based summary : Idiopathic Neutropenia, also known as nonimmune chronic idiopathic neutropenia of adults, is related to neutropenia, nonimmune chronic idiopathic, of adults and intussusception. An important gene associated with Idiopathic Neutropenia is GFI1 (Growth Factor Independent 1 Transcriptional Repressor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cilastatin and Imipenem have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Related Diseases for Idiopathic Neutropenia

Diseases related to Idiopathic Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
id Related Disease Score Top Affiliating Genes
1 neutropenia, nonimmune chronic idiopathic, of adults 11.7
2 intussusception 10.4 IL1B TNF
3 refractory celiac disease 10.4 IL10 TGFB1
4 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
5 neutropenia 10.3
6 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
7 warthin tumor 10.3 IL1B IL1RN TNF
8 plantar wart 10.3 IL10 TGFB1 TNF
9 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IL10 IL2RA TNF
10 brown shrimp allergy 10.3 IL10 IL2RA TGFB1
11 cerebellar disease 10.3 IL1A IL1B TNF
12 preaxial polydactyly of fingers 10.3 IL6 TGFB1 TNF
13 stocco dos santos syndrome 10.3 HMGB1 IL1B TNF
14 bipolar i disorder 10.3 IL1B IL6 TNF
15 coronary arterial fistulas 10.3 IL10 IL1RN TLR4
16 nasal cavity cancer 10.3 IL1B IL1RN TNF
17 tinea capitis 10.3 IL1B IL6 TNF
18 measles 10.3 IL1B IL6 TNF
19 hereditary night blindness 10.3 IL6 TGFB1 TNF
20 acquired thrombocytopenia 10.3 IL1B IL6 TNF
21 oral cavity carcinoma in situ 10.3 IL10 IL1B IL1RN
22 abnormal retinal correspondence 10.3 IL10 TLR4 TNF
23 migraine with aura 10.3 IL1B IL6 TNF
24 transient tic disorder 10.3 IL10 IL6 TNF
25 sarcomatoid transitional cell carcinoma 10.3 IL10 IL1A TNF
26 ciliary discoordination, due to random ciliary orientation 10.3 IL10 IL1A IL2RA
27 choanal atresia, bilateral 10.3 IL2RA IL6 TNF
28 cholera 10.3 IL1B IL6 TGFB1
29 glossitis 10.3 IL1A IL1B IL1RN
30 splenic artery aneurysm 10.3 IL1B IL6 TNF
31 childhood electroclinical syndrome 10.3 IL10 IL1B IL6
32 orthostatic proteinuria 10.2 IL1RN IL6 TNF
33 trichomalacia 10.2 IL10 IL6 TNF
34 phlyctenulosis 10.2 IL10 IL6 TNF
35 larynx leiomyoma 10.2 IL1B IL6 TLR4
36 gastric dilatation 10.2 IL10 IL6 TNF
37 crohn's colitis 10.2 IL6 TLR4 TNF
38 pancreas lymphoma 10.2 IL1B IL6 TNF
39 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DRB1 TGFB1 TNF
40 distal trisomy 14q 10.2 HLA-DRB1 TGFB1 TNF
41 balkan nephropathy 10.2 IL10 IL1B TNF
42 retinal vascular occlusion 10.2 IL1B IL1RN TNF
43 orbital osteomyelitis 10.2 IL10 IL6 TNF
44 pseudo-meigs syndrome 10.2 FASLG IL10 TNF
45 senile reticular retinal degeneration 10.2 IL10 IL1B IL1RN TNF
46 follicular adenoma 10.2 IL10 IL6 TNF
47 parkinson disease 11 10.2 IL10 IL1B TLR4 TNF
48 childhood central nervous system mixed germ cell tumor 10.2 IL10 IL1B IL1RN TNF
49 pericholangitis 10.2 HMGB1 TLR4 TNF
50 alcoholic hepatitis 10.2 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Idiopathic Neutropenia:



Diseases related to Idiopathic Neutropenia

Symptoms & Phenotypes for Idiopathic Neutropenia

GenomeRNAi Phenotypes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 IL2RA TGFB1 TNF CASP3 CD40LG IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 IL2RA TGFB1 TNF CASP3 CD40LG IL10
3 Decreased viability with paclitaxel GR00179-A-1 9.26 CASP3 IL10 TGFB1
4 Decreased viability with paclitaxel GR00179-A-3 9.26 TGFB1

MGI Mouse Phenotypes related to Idiopathic Neutropenia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.41 IL2RA IL6 TGFB1 THPO TLR4 TNF
2 immune system MP:0005387 10.36 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
3 cellular MP:0005384 10.3 CASP3 CD40LG CSF3R FASLG FCER2 GFI1
4 homeostasis/metabolism MP:0005376 10.3 CASP3 CD40LG FASLG FCER2 IL10 IL1A
5 cardiovascular system MP:0005385 10.28 CASP3 CD40LG FASLG IL10 IL1A IL1B
6 mortality/aging MP:0010768 10.21 IL2RA IL6 TGFB1 TLR4 TNF CASP3
7 digestive/alimentary MP:0005381 10.16 CASP3 FASLG FCER2 IL10 IL2RA IL6
8 endocrine/exocrine gland MP:0005379 10.15 CASP3 CD40LG FASLG GFI1 IL10 IL2RA
9 integument MP:0010771 10.14 IL1RN IL6 TGFB1 TLR4 TNF CASP3
10 neoplasm MP:0002006 9.92 FASLG IL10 IL1A IL1B IL6 TGFB1
11 reproductive system MP:0005389 9.91 CASP3 CD40LG FASLG IL10 IL1RN IL6
12 respiratory system MP:0005388 9.76 IL10 IL2RA IL6 TGFB1 TLR4 TNF
13 skeleton MP:0005390 9.65 CASP3 CD40LG FASLG IL10 IL1B IL1RN
14 vision/eye MP:0005391 9.23 IL6 TGFB1 TLR4 TNF CASP3 FASLG

Drugs & Therapeutics for Idiopathic Neutropenia

Drugs for Idiopathic Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilastatin Approved Phase 4 82009-34-5 5280454 6435415
2
Imipenem Approved Phase 4 74431-23-5 104838
3
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antitubercular Agents Phase 4
8 HIV Protease Inhibitors Phase 4
9
protease inhibitors Phase 4
10 Thienamycins Phase 4
11 Liver Extracts Phase 4
12
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
13
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
14
Amphotericin B Approved, Investigational Phase 2, Phase 3 1397-89-3 14956 5280965
15 Antifungal Agents Phase 3,Phase 2,Phase 1
16 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
17 Cytochrome P-450 CYP3A Inhibitors Phase 3,Phase 2
18 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
19 Hormone Antagonists Phase 3,Phase 2
20 Hormones Phase 3,Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
22 Steroid Synthesis Inhibitors Phase 3,Phase 2
23 Antiparasitic Agents Phase 2, Phase 3
24 Antiprotozoal Agents Phase 2, Phase 3
25 Liposomal amphotericin B Phase 2, Phase 3
26
Micafungin Approved, Investigational Phase 2 235114-32-6 3081921 477468
27
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
28
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
29 Echinocandins Phase 2
30 Antibodies Phase 2
31 Antibodies, Monoclonal Phase 2
32 Immunoglobulins Phase 2
33 Immunosuppressive Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
2 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Recruiting NCT02149329 Phase 4
3 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
4 Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic Patients Completed NCT00150345 Phase 3
5 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3
6 Antifungal Prophylaxis With Micafungin After Cord Blood Allogeneic Stem Cell Transplantation (MycaCOORD) Completed NCT01888458 Phase 2
7 Ilaris (Canakinumab) in the Schnitzler Syndrome Completed NCT01245127 Phase 2
8 A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Aplastic Anemia Patients With Immunosuppressive-Therapy Refractory Thrombocytopenia Active, not recruiting NCT00922883 Phase 2
9 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2
10 Study of Ezatiostat (Telintra Tablets) for Treatment of Severe Chronic Neutropenia Terminated NCT00909584 Phase 2
11 Early Antibiotic Discontinuation in FUO Completed NCT02906254
12 Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia Completed NCT02544230

Search NIH Clinical Center for Idiopathic Neutropenia

Genetic Tests for Idiopathic Neutropenia

Anatomical Context for Idiopathic Neutropenia

MalaCards organs/tissues related to Idiopathic Neutropenia:

39
Neutrophil, Bone, Bone Marrow, Myeloid, T Cells

Publications for Idiopathic Neutropenia

Articles related to Idiopathic Neutropenia:

(show all 37)
id Title Authors Year
1
An update on the diagnosis and treatment of chronic idiopathic neutropenia. ( 27841775 )
2017
2
Minor populations of paroxysmal nocturnal haemoglobinuria type cells in patients with chronic idiopathic neutropenia. ( 27124520 )
2016
3
Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination. ( 23417376 )
2013
4
Infectious complications in children with severe congenital, autoimmune or idiopathic neutropenia: a retrospective study from the Italian Neutropenia Registry. ( 23249920 )
2013
5
Association between helicobacter pylori infection and chronic idiopathic neutropenia. ( 23771659 )
2013
6
An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia. ( 22146088 )
2012
7
Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. ( 22133767 )
2012
8
Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. ( 22875614 )
2012
9
Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. ( 22956967 )
2012
10
Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. ( 22127462 )
2012
11
Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. ( 22092365 )
2012
12
Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-I^1. ( 21047210 )
2011
13
T-cell receptor VI^ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. ( 20864416 )
2010
14
Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance. ( 19823822 )
2010
15
Case history: individualized homeopathy and severe chronic idiopathic neutropenia (SCN). ( 20674845 )
2010
16
The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. ( 19614955 )
2009
17
Idiopathic neutropenia of childhood is associated with Fas/FasL expression. ( 18819843 )
2008
18
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. ( 21082926 )
2008
19
Chronic idiopathic neutropenias and severe congenital neutropenia. ( 18043240 )
2008
20
Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. ( 17961177 )
2007
21
Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia. ( 17188576 )
2007
22
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. ( 16391909 )
2006
23
Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. ( 16938119 )
2006
24
Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. ( 16432851 )
2006
25
Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. ( 16982324 )
2006
26
Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10. ( 17054669 )
2006
27
Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults. ( 15986200 )
2005
28
Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. ( 15014900 )
2004
29
Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. ( 15338195 )
2004
30
Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. ( 11807637 )
2002
31
Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography. ( 11488850 )
2001
32
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy. ( 11737689 )
2001
33
Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11202431 )
2001
34
Increased serum IgA and decreased IgG3 strongly correlate with increased serum TGF-beta1 levels in patients with nonimmune chronic idiopathic neutropenia of adults. ( 11073164 )
2000
35
Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. ( 11074551 )
2000
36
Prevention of infection in a patient with chronic idiopathic neutropenia undergoing coronary bypass surgery with peri-operative G-CSF. ( 8996068 )
1996
37
G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients. ( 8589368 )
1995

Variations for Idiopathic Neutropenia

ClinVar genetic disease variations for Idiopathic Neutropenia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GFI1 NM_005263.3(GFI1): c.1208A> G (p.Lys403Arg) single nucleotide variant Pathogenic rs28936382 GRCh37 Chromosome 1, 92941647: 92941647

Expression for Idiopathic Neutropenia

Search GEO for disease gene expression data for Idiopathic Neutropenia.

Pathways for Idiopathic Neutropenia

Pathways related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
2
Show member pathways
13.97 CASP3 CCL5 CD40LG CSF3R FASLG IL10
3
Show member pathways
13.76 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
4
Show member pathways
13.63 CCL5 IL10 IL1A IL1B IL2RA IL6
5
Show member pathways
13.49 CASP3 CCL5 CD40LG CSF3R FASLG IL10
6
Show member pathways
13.41 CASP3 CCL5 CD40LG CSF3R FASLG IL10
7
Show member pathways
13.31 FCER2 HLA-DRB1 HMGB1 IL1A IL1B IL2RA
8
Show member pathways
13.24 CASP3 CCL5 CD40LG CSF3R FASLG FCER2
9
Show member pathways
13.1 CCL5 IL1A IL1B IL1RN IL6 TLR4
10
Show member pathways
13.08 CASP3 CCL5 FASLG IL10 IL1B IL6
11
Show member pathways
12.97 CASP3 CCL5 FASLG HLA-DRB1 IL1A IL1B
12
Show member pathways
12.96 CASP3 CD40LG FASLG HLA-DRB1 IL10 IL1A
13
Show member pathways
12.95 CASP3 CCL5 FASLG IL6 TNF
14
Show member pathways
12.88 CD40LG IL1A IL1B IL6 TGFB1 THPO
15 12.83 CASP3 FASLG IL1A IL1B TGFB1 TNF
16
Show member pathways
12.8 CCL5 HMGB1 IL1B IL6 TNF
17
Show member pathways
12.78 CASP3 CD40LG FASLG IL1A IL1B TNF
18
Show member pathways
12.78 HLA-DRB1 IL10 IL1A IL1B IL2RA IL6
19
Show member pathways
12.76 CASP3 CD40LG FASLG IL1A IL1B TLR4
20 12.75 CASP3 CSF3R FASLG IL6 TGFB1
21 12.72 CCL5 CD40LG FASLG IL10 IL1B IL1RN
22
Show member pathways
12.71 CD40LG HLA-DRB1 IL10 IL2RA TNF
23 12.67 CSF3R FASLG IL2RA IL6 TLR4
24
Show member pathways
12.62 CD40LG IL10 IL1A IL1B IL6 TGFB1
25 12.54 HLA-DRB1 IL2RA IL6 TGFB1 TNF
26 12.42 CASP3 FASLG TGFB1 TLR4 TNF
27
Show member pathways
12.4 CCL5 IL1B IL6 TNF
28
Show member pathways
12.4 CASP3 IL1B IL6 TNF
29
Show member pathways
12.4 IL1A IL1B IL6 TLR4 TNF
30 12.37 CASP3 IL10 IL1A IL1B IL1RN IL6
31
Show member pathways
12.36 CASP3 CD40LG HLA-DRB1 IL10 IL1A IL1B
32
Show member pathways
12.34 IL1A IL6 TLR4 TNF
33
Show member pathways
12.34 CSF3R IL10 IL2RA IL6 THPO
34
Show member pathways
12.33 CASP3 FASLG IL1A TNF
35
Show member pathways
12.32 FASLG IL1B IL6 TLR4 TNF
36 12.31 CASP3 IL6 TGFB1 TLR4 TNF
37
Show member pathways
12.3 IL10 IL1A IL1B IL6 TNF
38 12.27 CASP3 HLA-DRB1 IL10 IL1A IL1B IL6
39 12.22 CASP3 IL1A IL1B IL6 TGFB1 TLR4
40 12.2 CSF3R IL10 IL2RA IL6 THPO TNF
41
Show member pathways
12.18 FASLG IL10 IL6 TGFB1
42 12.15 IL1A IL1B TGFB1 TNF
43
Show member pathways
12.15 IL10 IL1B IL6 TGFB1 TLR4 TNF
44
Show member pathways
12.13 IL1A IL1B IL2RA TLR4
45 12.12 CASP3 CCL5 IL1B IL6 TNF
46 12.12 FASLG FCER2 IL10 IL1A IL1B IL6
47 12.11 CASP3 IL1A IL1B IL6 TGFB1 TNF
48
Show member pathways
12.09 FASLG HLA-DRB1 IL1B IL2RA
49 12.09 CASP3 IL10 IL1B IL6 TGFB1 TLR4
50 12.05 IL1A IL1B IL6 TGFB1

GO Terms for Idiopathic Neutropenia

Cellular components related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
2 cell surface GO:0009986 9.86 CD40LG FASLG HLA-DRB1 HMGB1 IL2RA TGFB1
3 extracellular region GO:0005576 9.8 CCL5 CD40LG CSF3R FASLG FCER2 HMGB1
4 external side of plasma membrane GO:0009897 9.23 CD40LG FASLG FCER2 HLA-DRB1 IL2RA IL6

Biological processes related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 CASP3 FASLG IL10 IL1B IL6 TLR4
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.96 IL10 IL1B IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.95 GFI1 IL10 IL6 TLR4 TNF
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.93 CASP3 FASLG TNF
5 response to wounding GO:0009611 9.93 CASP3 IL6 TGFB1
6 response to organic substance GO:0010033 9.93 CASP3 IL10 TGFB1 TNF
7 cellular response to mechanical stimulus GO:0071260 9.92 IL1B TGFB1 TLR4
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.92 IL6 TGFB1 TNF
9 regulation of insulin secretion GO:0050796 9.92 CCL5 IL1B TNF
10 neutrophil chemotaxis GO:0030593 9.92 CCL5 CSF3R IL1B
11 positive regulation of epithelial cell proliferation GO:0050679 9.91 CCL5 IL6 TGFB1
12 positive regulation of protein kinase B signaling GO:0051897 9.91 IL6 TGFB1 THPO TNF
13 apoptotic signaling pathway GO:0097190 9.91 CASP3 FASLG TLR4 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 CCL5 IL6 TNF
15 positive regulation of cell division GO:0051781 9.89 IL1A IL1B TGFB1
16 positive regulation of JNK cascade GO:0046330 9.89 HMGB1 IL1B TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.88 IL1B TLR4 TNF
18 negative regulation of fat cell differentiation GO:0045599 9.88 IL6 TGFB1 TNF
19 extrinsic apoptotic signaling pathway GO:0097191 9.88 FASLG TGFB1 TNF
20 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG IL1B IL6 TGFB1 TLR4 TNF
21 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CCL5 HMGB1 IL6 TGFB1 THPO TLR4
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 IL1A IL1B TNF
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.85 CASP3 IL1A IL1B
24 cellular response to organic cyclic compound GO:0071407 9.85 CASP3 CCL5 IL1B TGFB1 TNF
25 T cell homeostasis GO:0043029 9.84 CASP3 IL2RA TGFB1
26 positive regulation of cytokine secretion GO:0050715 9.84 IL10 IL1A TNF
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 IL1B IL6 TLR4 TNF
28 negative regulation of mitotic cell cycle GO:0045930 9.83 IL10 TGFB1 TNF
29 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 IL1A IL1B TGFB1
30 negative regulation of T cell proliferation GO:0042130 9.83 HLA-DRB1 IL10 IL2RA TGFB1
31 positive regulation of T cell proliferation GO:0042102 9.83 CCL5 CD40LG IL1B IL2RA IL6
32 positive regulation of interleukin-8 production GO:0032757 9.82 IL1B TLR4 TNF
33 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR4 TNF
34 positive regulation of interleukin-12 production GO:0032735 9.81 CD40LG HMGB1 TLR4
35 protein kinase B signaling GO:0043491 9.81 CCL5 IL1B TGFB1 TNF
36 positive regulation of interleukin-10 production GO:0032733 9.8 CD40LG HMGB1 TLR4
37 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 IL1B TLR4 TNF
38 negative regulation of interferon-gamma production GO:0032689 9.78 HLA-DRB1 HMGB1 IL10 TLR4
39 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR4 TNF
40 positive regulation of interleukin-6 production GO:0032755 9.77 IL1A IL1B IL6 TLR4 TNF
41 activation of innate immune response GO:0002218 9.76 HMGB1 TLR4
42 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.76 IL1A IL1B
43 T-helper 1 type immune response GO:0042088 9.75 HLA-DRB1 TLR4
44 negative regulation of interleukin-17 production GO:0032700 9.75 TGFB1 TLR4
45 positive regulation of interferon-alpha production GO:0032727 9.75 HMGB1 TLR4
46 positive regulation of chemokine biosynthetic process GO:0045080 9.75 IL1B TNF
47 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
48 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL10 IL1RN
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR4 TNF
50 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 IL1A IL1B

Molecular functions related to Idiopathic Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL10 IL6 TGFB1 THPO
2 cytokine activity GO:0005125 9.4 CCL5 CD40LG FASLG HMGB1 IL10 IL1A
3 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG FASLG TNF
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Idiopathic Neutropenia

3 CDC
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16 ExPASy
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34 ICD10 via Orphanet
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60 QIAGEN
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70 UMLS via Orphanet
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