MCID: IDP041
MIFTS: 32

Idiopathic Recurrent Pericarditis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Recurrent Pericarditis

MalaCards integrated aliases for Idiopathic Recurrent Pericarditis:

Name: Idiopathic Recurrent Pericarditis 55
Idiopathic Relapsing Pericarditis 55

Characteristics:

Orphanet epidemiological data:

55
idiopathic recurrent pericarditis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 55 ORPHA251307
ICD10 via Orphanet 33 I09.2

Summaries for Idiopathic Recurrent Pericarditis

MalaCards based summary : Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and periodic fever, familial, autosomal dominant. An important gene associated with Idiopathic Recurrent Pericarditis is LEP (Leptin), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Circadian rythm related genes. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Idiopathic Recurrent Pericarditis

Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 pericarditis 30.3 MEFV TNFRSF1A
2 periodic fever, familial, autosomal dominant 29.3 MEFV TNFRSF1A
3 familial mediterranean fever 29.2 MEFV TNFRSF1A
4 abdominal obesity-metabolic syndrome 1 10.2 ADIPOQ LEP
5 nontuberculous mycobacterial lung disease 10.2 ADIPOQ LEP
6 prediabetes syndrome 10.2 ADIPOQ LEP
7 apnea, obstructive sleep 10.2 ADIPOQ LEP
8 endocrine pancreas disease 10.2 ADIPOQ LEP
9 acanthosis nigricans 10.2 ADIPOQ LEP
10 severe pre-eclampsia 10.1 ADIPOQ LEP
11 eating disorder 10.1 ADIPOQ LEP
12 inherited metabolic disorder 10.1 ADIPOQ LEP
13 sleep apnea 10.1 ADIPOQ LEP
14 arteries, anomalies of 10.0 ADIPOQ LEP
15 uremia 10.0 LEP RETN
16 lipodystrophy 9.9 ADIPOQ LEP
17 inflammatory myopathy with abundant macrophages 9.9 MEFV TNFRSF1A
18 intermittent hydrarthrosis 9.9 MEFV TNFRSF1A
19 acquired generalized lipodystrophy 9.9 ADIPOQ LEP RETN
20 obesity-hypoventilation syndrome 9.9 ADIPOQ LEP RETN
21 multiple symmetrical lipomatosis 9.9 ADIPOQ LEP RETN
22 lutheran suppressor, x-linked 9.9 ADIPOQ LEP RETN
23 familial cold autoinflammatory syndrome 1 9.9 MEFV TNFRSF1A
24 nonalcoholic steatohepatitis 9.9 ADIPOQ LEP RETN
25 coronary artery aneurysm 9.9 ADIPOQ LEP RETN
26 bulimia nervosa 2 9.9 ADIPOQ LEP RETN
27 relapsing fever 9.9 MEFV TNFRSF1A
28 morbid obesity 9.9 ADIPOQ LEP RETN
29 lipid metabolism disorder 9.9 ADIPOQ LEP RETN
30 glucose metabolism disease 9.9 ADIPOQ LEP RETN
31 acquired metabolic disease 9.9 ADIPOQ LEP RETN
32 glucose intolerance 9.9 ADIPOQ LEP RETN
33 fatty liver disease 9.8 ADIPOQ LEP RETN
34 prader-willi syndrome 9.8 ADIPOQ LEP RETN
35 muckle-wells syndrome 9.8 MEFV TNFRSF1A
36 wells syndrome 9.8 MEFV TNFRSF1A
37 palindromic rheumatism 9.8 MEFV TNFRSF1A
38 hypertension, essential 9.8 ADIPOQ LEP RETN
39 atherosclerosis susceptibility 9.8 ADIPOQ RETN
40 amyloidosis, familial visceral 9.8 MEFV TNFRSF1A
41 psoriatic arthritis 9.7
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
43 arthritis 9.7
44 brucellosis 9.7
45 vascular disease 9.7 ADIPOQ NAMPT RETN
46 liver disease 9.6 ADIPOQ LEP TNFRSF1A
47 overnutrition 9.4 ADIPOQ LEP NAMPT RETN
48 gestational diabetes 9.4 ADIPOQ LEP NAMPT RETN
49 body mass index quantitative trait locus 11 9.4 ADIPOQ LEP NAMPT RETN
50 diabetes mellitus, noninsulin-dependent 9.4 ADIPOQ LEP NAMPT RETN

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to Idiopathic Recurrent Pericarditis

Symptoms & Phenotypes for Idiopathic Recurrent Pericarditis

MGI Mouse Phenotypes related to Idiopathic Recurrent Pericarditis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ADIPOQ LEP MEFV NAMPT RETN TNFRSF1A
2 hematopoietic system MP:0005397 9.72 ADIPOQ LEP MEFV NAMPT TNFRSF1A
3 adipose tissue MP:0005375 9.67 ADIPOQ LEP RETN TNFRSF1A
4 immune system MP:0005387 9.63 ADIPOQ LEP MEFV NAMPT RETN TNFRSF1A
5 integument MP:0010771 9.35 ADIPOQ LEP MEFV NAMPT TNFRSF1A
6 liver/biliary system MP:0005370 9.02 RETN TNFRSF1A ADIPOQ LEP MEFV

Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

Drugs for Idiopathic Recurrent Pericarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 4
2 Antirheumatic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP) Completed NCT02219828 Phase 4 Anakinra;Placebo

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

Anatomical Context for Idiopathic Recurrent Pericarditis

MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

38
Bone

Publications for Idiopathic Recurrent Pericarditis

Articles related to Idiopathic Recurrent Pericarditis:

(show all 25)
# Title Authors Year
1
Treatment of Adults with Idiopathic Recurrent Pericarditis: Novel Use of Immunotherapy. ( 28079270 )
2017
2
The Therapeutic Role of Interleukin-1 Inhibition in Idiopathic Recurrent Pericarditis: Current Evidence and Future Challenges. ( 28660191 )
2017
3
Refractory idiopathic recurrent pericarditis: treatment with interleukin-1 receptor antagonist is an option! ( 28746150 )
2017
4
The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. ( 26942035 )
2016
5
Usefulness of Novel Immunotherapeutic Strategies for Idiopathic Recurrent Pericarditis. ( 26742476 )
2016
6
Anakinra: an emerging option for refractory idiopathic recurrent pericarditis: a systematic review of published evidence. ( 26090915 )
2015
7
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. ( 25088882 )
2014
8
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. ( 25307995 )
2014
9
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. ( 25165036 )
2014
10
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. ( 23981280 )
2013
11
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. ( 23052671 )
2013
12
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. ( 21170606 )
2013
13
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). ( 23463131 )
2013
14
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). ( 23711245 )
2013
15
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. ( 23137677 )
2013
16
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). ( 22704870 )
2012
17
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. ( 22155373 )
2012
18
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. ( 19644862 )
2009
19
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? ( 19116906 )
2009
20
Idiopathic recurrent pericarditis: searching for Ariadne's thread. ( 19767277 )
2009
21
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. ( 20074469 )
2009
22
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. ( 17826391 )
2007
23
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. ( 12690925 )
2003
24
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. ( 14224691 )
1965
25
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. ( 14361444 )
1955

Variations for Idiopathic Recurrent Pericarditis

Expression for Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for Idiopathic Recurrent Pericarditis

GO Terms for Idiopathic Recurrent Pericarditis

Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 ADIPOQ LEP NAMPT RETN TNFRSF1A
2 extracellular space GO:0005615 9.02 ADIPOQ LEP NAMPT RETN TNFRSF1A

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.55 ADIPOQ LEP
2 glucose homeostasis GO:0042593 9.54 ADIPOQ LEP
3 female pregnancy GO:0007565 9.52 LEP NAMPT
4 response to nutrient GO:0007584 9.51 ADIPOQ LEP
5 response to insulin GO:0032868 9.49 LEP RETN
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 LEP TNFRSF1A
7 glucose metabolic process GO:0006006 9.46 ADIPOQ LEP
8 regulation of receptor activity GO:0010469 9.46 ADIPOQ LEP NAMPT RETN
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 NAMPT RETN
10 response to nutrient levels GO:0031667 9.4 ADIPOQ LEP
11 fatty acid beta-oxidation GO:0006635 9.37 ADIPOQ LEP
12 response to activity GO:0014823 9.32 ADIPOQ LEP
13 adipose tissue development GO:0060612 9.26 LEP NAMPT
14 negative regulation of inflammatory response GO:0050728 9.13 ADIPOQ MEFV TNFRSF1A
15 circadian rhythm GO:0007623 8.8 ADIPOQ LEP NAMPT

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 ADIPOQ LEP RETN

Sources for Idiopathic Recurrent Pericarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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