MCID: IDP041
MIFTS: 41

Idiopathic Recurrent Pericarditis malady

Bone diseases, Rare diseases categories

Summaries for Idiopathic Recurrent Pericarditis

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34MalaCards
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MalaCards: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds bcma and blys have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

50
idiopathic recurrent pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

idiopathic recurrent pericarditis 50
idiopathic relapsing pericarditis 50


External Ids:

ICD10 via Orphanet27 I09.2

Related Diseases for Idiopathic Recurrent Pericarditis

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18GeneCards, 19GeneDecks
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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis31.3MEFV
2arthritis30.3TNFRSF1A, TNF
3psoriatic arthritis30.3TNF, TNFRSF1A
4palindromic rheumatism10.1MEFV
5erysipelas10.1MEFV
6leishmaniasis10.1TNFRSF1A
7familial cold autoinflammatory syndrome10.1MEFV, TNFRSF1A
8chronic infantile neurological cutaneous articular syndrome10.1MEFV, TNFRSF1A
9muckle-wells syndrome10.1TNFRSF1A, MEFV
10relapsing fever10.1MEFV, TNFRSF1A
11blau syndrome10.1MEFV, TNF
12behcet's disease10.0TNF, MEFV
13peritonitis10.0TNF, MEFV
14rheumatic disease10.0TNF, MEFV
15arthropathy10.0RETN, TNF
16ankylosing spondylitis10.0TNF, TNFRSF1A
17amyloidosis10.0TNFRSF1A, MEFV
18graft versus host disease10.0TNF, TNFRSF1A
19uveitis10.0TNFRSF1A, TNF
20synovitis10.0TNFRSF1A, TNF
21vasculitis10.0TNF, MEFV
22monocytic leukemia10.0TNFRSF1A, TNF
23galactosemia10.0TNF, LEP
24bulimia nervosa10.0LEP, RETN
25periodic fever, familial, autosomal dominant10.0MEFV, TNF, TNFRSF1A
26eating disorder10.0LEP, RETN
27familial mediterranean fever10.0TNFRSF1A, TNF, MEFV
28hyperinsulinism10.0RETN, LEP
29fatty liver disease10.0LEP, RETN
30obstructive sleep apnea10.0LEP, ADIPOQ
31congenital generalized lipodystrophy type 210.0LEP, ADIPOQ
32metabolic syndrome x10.0ADIPOQ, LEP
33acanthosis nigricans10.0LEP, ADIPOQ
34growth hormone deficiency10.0LEP, ADIPOQ
35vascular disease10.0NAMPT, RETN, ADIPOQ
36coronary artery disease10.0ADIPOQ, RETN, NAMPT
37inflammatory bowel disease10.0RETN, TNFRSF1A, TNF
38hyperthyroidism10.0LEP, RETN
39osteoarthritis10.0TNFRSF1A, RETN, TNF
40hypersensitivity reaction type ii disease10.0TNF, TNFRSF1A
41bronchitis10.0LEP, ADIPOQ
42hypogonadism10.0ADIPOQ, LEP
43congenital heart disease10.0RETN, ADIPOQ, TNF
44hypothyroidism10.0LEP, RETN
45hypertriglyceridemia10.0LEP, ADIPOQ
46septic shock10.0TNFRSF1A, TNF
47acquired generalized lipodystrophy10.0RETN, ADIPOQ, LEP
48morbid obesity10.0LEP, ADIPOQ, RETN
49hyperandrogenism10.0ADIPOQ, LEP, RETN
50lipodystrophy10.0ADIPOQ, RETN, LEP

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Symptoms for Idiopathic Recurrent Pericarditis

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Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

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Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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34MalaCards
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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

34
Bone

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

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38MGI
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Publications for Idiopathic Recurrent Pericarditis

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53PubMed
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Articles related to Idiopathic Recurrent Pericarditis:

(show all 15)
idTitleAuthorsYear
1
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
2
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
3
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
4
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
5
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
6
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
7
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
8
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
9
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
10
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
11
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
12
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
13
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
14
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
15
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 55R&D Systems, 13EMD Millipore, 52PharmGKB
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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF1A
2
Show member pathways
9.6MEFV, TNF
3
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.4TNFRSF1A, TNF
49.4TNFRSF1A, TNF
59.4TNF, TNFRSF1A
6
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.4TNF, TNFRSF1A
7
Show member pathways
9.4TNFRSF1A, TNF
89.4TNFRSF1A, TNF
9
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4TNFRSF1A, TNF
10
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.4TNF, TNFRSF1A
119.4TNFRSF1A, TNF
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.4TNFRSF1A, TNF
139.4TNFRSF1A, TNF
14
Show member pathways
9.4TNFRSF1A, TNF
159.4TNF, TNFRSF1A
16
Show member pathways
9.4TNFRSF1A, TNF
17
Show member pathways
9.4TNF, TNFRSF1A
189.4RETN, ADIPOQ
199.4RETN, ADIPOQ
20
Show member pathways
9.3ADIPOQ, TNF
219.0ADIPOQ, LEP
22
Show member pathways
8.5ADIPOQ, TNF, LEP
23
Show member pathways
8.5ADIPOQ, TNF, LEP
248.0ADIPOQ, TNFRSF1A, TNF, LEP
25
Show member pathways
8.0LEP, TNF, TNFRSF1A, ADIPOQ
267.6LEP, TNF, NAMPT, ADIPOQ, RETN
27
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
7.1RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1bcma469.7TNF, TNFRSF1A
2blys469.6TNFRSF1A, TNF
3actinomycin469.5TNFRSF1A, TNF
4clenbuterol46 1210.4TNF, LEP
5tab-1469.3TNFRSF1A, TNF
62-arachidonoylglycerol46 3010.3ADIPOQ, LEP
7rimonabant46 30 1211.3ADIPOQ, LEP
8stavudine46 1210.2ADIPOQ, LEP
9atorvastatin46 52 30 25 1213.2TNF, ADIPOQ, RETN
10infliximab46 52 1211.2TNFRSF1A, ADIPOQ, TNF
11sibutramine46 1210.2ADIPOQ, LEP
12simvastatin46 52 62 30 25 1214.1TNF, ADIPOQ, TNFRSF1A
13topiramate46 52 25 1212.0LEP, ADIPOQ
14thiazolidinedione469.0LEP, ADIPOQ, RETN
1511beta-hydroxysteroid469.0ADIPOQ, LEP, RETN
16c-peptide468.9ADIPOQ, RETN, LEP
17dhea468.9LEP, ADIPOQ, RETN
18uric acid46 259.9LEP, RETN, ADIPOQ
19thyroxine46 259.8ADIPOQ, LEP, RETN
20troglitazone46 30 62 1211.8TNF, LEP, ADIPOQ
21acipimox46 309.7LEP, ADIPOQ
22actinomycin d468.7RETN, ADIPOQ, TNFRSF1A, TNF
23metformin46 52 1210.6LEP, RETN, ADIPOQ, NAMPT
24vitamin a46 25 1210.6ADIPOQ, LEP, RETN
25fatty acid468.5RETN, ADIPOQ, LEP, NAMPT
268-isoprostane468.5LEP, TNF, RETN, ADIPOQ
27fenofibrate46 52 1210.5LEP, ADIPOQ, TNF, RETN
28cycloheximide468.5TNFRSF1A, LEP, RETN, TNF
29p003468.5ADIPOQ, TNFRSF1A, LEP, RETN
30p002468.5RETN, LEP, TNFRSF1A, ADIPOQ
31norepinephrine46 25 1210.4TNFRSF1A, LEP, RETN, ADIPOQ
32ly294002468.4RETN, ADIPOQ, TNF, LEP
33etanercept46 52 1210.4ADIPOQ, LEP, TNF, TNFRSF1A
34endotoxin468.4RETN, MEFV, ADIPOQ, TNFRSF1A, TNF
35estradiol46 25 1210.4TNFRSF1A, RETN, ADIPOQ, LEP
36prostacyclin468.4ADIPOQ, TNFRSF1A, LEP, TNF
37methotrexate52 46 1210.4LEP, TNF, TNFRSF1A, ADIPOQ
38testosterone46 62 25 1211.3TNFRSF1A, ADIPOQ, LEP, RETN
39h2o2468.3LEP, TNF, ADIPOQ, TNFRSF1A
40vegf468.2TNFRSF1A, TNF, LEP, RETN
41pioglitazone30 46 52 1211.1LEP, RETN, ADIPOQ, NAMPT, TNF
42rosiglitazone30 46 52 25 1212.1RETN, NAMPT, TNF, ADIPOQ, LEP
43fibrinogen468.1NAMPT, RETN, ADIPOQ, TNF, LEP
44creatinine468.1LEP, ADIPOQ, RETN, TNFRSF1A, NAMPT
45cholesterol46 30 25 1211.1RETN, LEP, TNFRSF1A, NAMPT, ADIPOQ
46phosphatidylinositol468.0NAMPT, TNFRSF1A, ADIPOQ, LEP, RETN
47glucose468.0LEP, RETN, ADIPOQ, NAMPT, TNFRSF1A
48nash468.0LEP, RETN, TNF, TNFRSF1A, ADIPOQ
49dexamethasone46 52 30 1210.6NAMPT, TNF, TNFRSF1A, RETN, ADIPOQ, LEP
50lipid467.5RETN, ADIPOQ, LEP, NAMPT, TNFRSF1A, TNF

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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17Gene Ontology
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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.5TNF, TNFRSF1A, ADIPOQ
2extracellular regionGO:0055768.0ADIPOQ, TNFRSF1A, TNF, LEP
3extracellular spaceGO:0056157.0RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:0508069.8TNF, RETN
2negative regulation of interleukin-6 productionGO:0327159.7TNFRSF1A, TNF
3positive regulation of smooth muscle cell proliferationGO:0486619.7TNF, RETN
4extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNFRSF1A, TNF
5response to activityGO:0148239.6ADIPOQ, TNF
6response to mechanical stimulusGO:0096129.6RETN, TNF
7negative regulation of fat cell differentiationGO:0455999.6ADIPOQ, TNF
8intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.5TNF, TNFRSF1A
9adipose tissue developmentGO:0606129.5LEP, NAMPT
10leukocyte tethering or rollingGO:0509019.5LEP, TNF
11positive regulation of cytokine productionGO:0018199.4TNF, LEP
12response to insulinGO:0328689.3RETN, LEP
13response to ethanolGO:0454719.3ADIPOQ, TNFRSF1A
14response to glucocorticoidGO:0513849.3TNF, ADIPOQ
15negative regulation of gene expressionGO:0106299.3TNF, TNFRSF1A
16inflammatory responseGO:0069549.3TNF, TNFRSF1A, MEFV
17negative regulation of inflammatory responseGO:0507289.3TNFRSF1A, ADIPOQ, MEFV
18circadian rhythmGO:0076239.2ADIPOQ, LEP
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1ADIPOQ, TNFRSF1A, TNF
20glucose metabolic processGO:0060068.8ADIPOQ, TNF, LEP
21regulation of insulin secretionGO:0507968.8TNF, LEP
22response to hypoxiaGO:0016668.3ADIPOQ, TNFRSF1A, TNF, LEP

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4TNFRSF1A, TNF
2cytokine activityGO:0051258.6ADIPOQ, NAMPT, TNF
3hormone activityGO:0051798.5RETN, ADIPOQ, LEP

Products for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources for Idiopathic Recurrent Pericarditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet