MCID: IDP041
MIFTS: 42

Idiopathic Recurrent Pericarditis malady

Bone diseases, Rare diseases categories
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Summaries for Idiopathic Recurrent Pericarditis

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MalaCards based summary: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds bcma and blys have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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Sources:
48Orphanet, 26ICD10 via Orphanet
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Idiopathic Recurrent Pericarditis, Aliases & Descriptions:

Name: Idiopathic Recurrent Pericarditis 48
 
Idiopathic Relapsing Pericarditis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
idiopathic recurrent pericarditis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

ICD10 via Orphanet26 I09.2

Related Diseases for Idiopathic Recurrent Pericarditis

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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis32.0MEFV
2arthritis30.5TNFRSF1A, TNF
3psoriatic arthritis30.5TNF, TNFRSF1A
4familial mediterranean fever30.3TNFRSF1A, TNF, MEFV
5palindromic rheumatism10.5MEFV
6erysipelas10.5MEFV
7leishmaniasis10.4TNFRSF1A
8familial cold autoinflammatory syndrome10.3MEFV, TNFRSF1A
9chronic infantile neurological cutaneous articular syndrome10.3MEFV, TNFRSF1A
10muckle-wells syndrome10.3TNFRSF1A, MEFV
11relapsing fever10.3MEFV, TNFRSF1A
12blau syndrome10.3MEFV, TNF
13behcet's disease10.2TNF, MEFV
14peritonitis10.2TNF, MEFV
15rheumatic disease10.2TNF, MEFV
16arthropathy10.2RETN, TNF
17ankylosing spondylitis10.2TNF, TNFRSF1A
18amyloidosis10.2TNFRSF1A, MEFV
19graft versus host disease10.1TNF, TNFRSF1A
20uveitis10.1TNFRSF1A, TNF
21synovitis10.1TNFRSF1A, TNF
22vasculitis10.1TNF, MEFV
23monocytic leukemia10.1TNFRSF1A, TNF
24galactosemia10.1TNF, LEP
25bulimia nervosa10.1LEP, RETN
26periodic fever, familial, autosomal dominant10.1MEFV, TNF, TNFRSF1A
27eating disorder10.1LEP, RETN
28hyperinsulinism10.1RETN, LEP
29fatty liver disease10.0LEP, RETN
30obstructive sleep apnea10.0LEP, ADIPOQ
31congenital generalized lipodystrophy type 210.0LEP, ADIPOQ
32metabolic syndrome x10.0ADIPOQ, LEP
33acanthosis nigricans10.0LEP, ADIPOQ
34growth hormone deficiency10.0LEP, ADIPOQ
35vascular disease10.0NAMPT, RETN, ADIPOQ
36coronary artery anomaly10.0ADIPOQ, RETN, NAMPT
37inflammatory bowel disease10.0RETN, TNFRSF1A, TNF
38hyperthyroidism10.0LEP, RETN
39osteoarthritis10.0TNFRSF1A, RETN, TNF
40hypersensitivity reaction type ii disease10.0TNF, TNFRSF1A
41non-suppurative otitis media10.0LEP, ADIPOQ
42hypogonadism9.9ADIPOQ, LEP
43congenital heart disease9.9RETN, ADIPOQ, TNF
44hypothyroidism9.9LEP, RETN
45hypertriglyceridemia9.9LEP, ADIPOQ
46septic shock9.9TNFRSF1A, TNF
47acquired generalized lipodystrophy9.9RETN, ADIPOQ, LEP
48morbid obesity9.8LEP, ADIPOQ, RETN
49hyperandrogenism9.8ADIPOQ, LEP, RETN
50lipodystrophy9.8ADIPOQ, RETN, LEP

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Symptoms for Idiopathic Recurrent Pericarditis

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Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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Drug clinical trials:

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Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

32
Bone

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

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Publications for Idiopathic Recurrent Pericarditis

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Articles related to Idiopathic Recurrent Pericarditis:

(show all 19)
idTitleAuthorsYear
1
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. (25165036)
2014
2
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. (25088882)
2014
3
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. (25307995)
2014
4
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
5
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
6
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
7
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
8
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
9
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
10
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
11
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). (22704870)
2012
12
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
13
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
14
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
15
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
16
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
17
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
18
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
19
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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Expression patterns in normal tissues for genes affiliated with Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF1A
2
Show member pathways
9.6MEFV, TNF
3
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.4TNFRSF1A, TNF
49.4TNFRSF1A, TNF
59.4TNF, TNFRSF1A
6
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.4TNF, TNFRSF1A
7
Show member pathways
9.4TNFRSF1A, TNF
89.4TNFRSF1A, TNF
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4TNFRSF1A, TNF
10
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.4TNF, TNFRSF1A
119.4TNFRSF1A, TNF
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.4TNFRSF1A, TNF
139.4TNFRSF1A, TNF
14
Show member pathways
9.4TNFRSF1A, TNF
159.4TNF, TNFRSF1A
16
Show member pathways
9.4TNFRSF1A, TNF
17
Show member pathways
9.4TNF, TNFRSF1A
189.4RETN, ADIPOQ
199.4RETN, ADIPOQ
20
Show member pathways
9.3ADIPOQ, TNF
219.0ADIPOQ, LEP
22
Show member pathways
8.5ADIPOQ, TNF, LEP
23
Show member pathways
8.5ADIPOQ, TNF, LEP
248.0ADIPOQ, TNFRSF1A, TNF, LEP
25
Show member pathways
8.0LEP, TNF, TNFRSF1A, ADIPOQ
267.6LEP, TNF, NAMPT, ADIPOQ, RETN
27
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
7.1RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1bcma449.7TNF, TNFRSF1A
2blys449.6TNFRSF1A, TNF
3actinomycin449.5TNFRSF1A, TNF
4clenbuterol44 1110.4TNF, LEP
5tab-1449.3TNFRSF1A, TNF
62-arachidonoylglycerol44 2810.3ADIPOQ, LEP
7rimonabant44 28 1111.3ADIPOQ, LEP
8stavudine44 1110.2ADIPOQ, LEP
9atorvastatin44 50 28 24 1113.2TNF, ADIPOQ, RETN
10infliximab44 50 1111.2TNFRSF1A, ADIPOQ, TNF
11sibutramine44 1110.2ADIPOQ, LEP
12simvastatin44 50 61 28 24 1114.1TNF, ADIPOQ, TNFRSF1A
13topiramate44 50 24 1112.0LEP, ADIPOQ
14thiazolidinedione449.0LEP, ADIPOQ, RETN
1511beta-hydroxysteroid449.0ADIPOQ, LEP, RETN
16c-peptide448.9ADIPOQ, RETN, LEP
17dhea448.9LEP, ADIPOQ, RETN
18uric acid44 249.9LEP, RETN, ADIPOQ
19thyroxine44 249.8ADIPOQ, LEP, RETN
20troglitazone44 28 61 1111.8TNF, LEP, ADIPOQ
21acipimox44 289.7LEP, ADIPOQ
22actinomycin d448.7RETN, ADIPOQ, TNFRSF1A, TNF
23metformin44 50 1110.6LEP, RETN, ADIPOQ, NAMPT
24vitamin a44 24 1110.6ADIPOQ, LEP, RETN
25fatty acid448.5RETN, ADIPOQ, LEP, NAMPT
268-isoprostane448.5LEP, TNF, RETN, ADIPOQ
27fenofibrate44 50 1110.5LEP, ADIPOQ, TNF, RETN
28cycloheximide448.5TNFRSF1A, LEP, RETN, TNF
29p003448.5ADIPOQ, TNFRSF1A, LEP, RETN
30p002448.5RETN, LEP, TNFRSF1A, ADIPOQ
31norepinephrine44 24 1110.4TNFRSF1A, LEP, RETN, ADIPOQ
32ly294002448.4RETN, ADIPOQ, TNF, LEP
33etanercept44 50 1110.4ADIPOQ, LEP, TNF, TNFRSF1A
34endotoxin448.4RETN, MEFV, ADIPOQ, TNFRSF1A, TNF
35estradiol44 24 1110.4TNFRSF1A, RETN, ADIPOQ, LEP
36prostacyclin448.4ADIPOQ, TNFRSF1A, LEP, TNF
37methotrexate50 44 1110.4LEP, TNF, TNFRSF1A, ADIPOQ
38testosterone44 61 24 1111.3TNFRSF1A, ADIPOQ, LEP, RETN
39h2o2448.3LEP, TNF, ADIPOQ, TNFRSF1A
40vegf448.2TNFRSF1A, TNF, LEP, RETN
41pioglitazone28 44 50 1111.1LEP, RETN, ADIPOQ, NAMPT, TNF
42rosiglitazone28 44 50 24 1112.1RETN, NAMPT, TNF, ADIPOQ, LEP
43fibrinogen448.1NAMPT, RETN, ADIPOQ, TNF, LEP
44creatinine448.1LEP, ADIPOQ, RETN, TNFRSF1A, NAMPT
45cholesterol44 28 24 1111.1RETN, LEP, TNFRSF1A, NAMPT, ADIPOQ
46phosphatidylinositol448.0NAMPT, TNFRSF1A, ADIPOQ, LEP, RETN
47glucose448.0LEP, RETN, ADIPOQ, NAMPT, TNFRSF1A
48nash448.0LEP, RETN, TNF, TNFRSF1A, ADIPOQ
49dexamethasone44 50 28 1110.6NAMPT, TNF, TNFRSF1A, RETN, ADIPOQ, LEP
50lipid447.5RETN, ADIPOQ, LEP, NAMPT, TNFRSF1A, TNF

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.5TNF, TNFRSF1A, ADIPOQ
2extracellular regionGO:0055768.0ADIPOQ, TNFRSF1A, TNF, LEP
3extracellular spaceGO:0056157.0RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:0508069.8TNF, RETN
2negative regulation of interleukin-6 productionGO:0327159.7TNFRSF1A, TNF
3positive regulation of smooth muscle cell proliferationGO:0486619.7TNF, RETN
4extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNFRSF1A, TNF
5response to activityGO:0148239.6ADIPOQ, TNF
6response to mechanical stimulusGO:0096129.6RETN, TNF
7negative regulation of fat cell differentiationGO:0455999.6ADIPOQ, TNF
8intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.5TNF, TNFRSF1A
9adipose tissue developmentGO:0606129.5LEP, NAMPT
10leukocyte tethering or rollingGO:0509019.5LEP, TNF
11positive regulation of cytokine productionGO:0018199.4TNF, LEP
12response to insulinGO:0328689.3RETN, LEP
13response to ethanolGO:0454719.3ADIPOQ, TNFRSF1A
14response to glucocorticoidGO:0513849.3TNF, ADIPOQ
15negative regulation of gene expressionGO:0106299.3TNF, TNFRSF1A
16inflammatory responseGO:0069549.3TNF, TNFRSF1A, MEFV
17negative regulation of inflammatory responseGO:0507289.3TNFRSF1A, ADIPOQ, MEFV
18circadian rhythmGO:0076239.2ADIPOQ, LEP
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1ADIPOQ, TNFRSF1A, TNF
20glucose metabolic processGO:0060068.8ADIPOQ, TNF, LEP
21regulation of insulin secretionGO:0507968.8TNF, LEP
22response to hypoxiaGO:0016668.3ADIPOQ, TNFRSF1A, TNF, LEP

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4TNFRSF1A, TNF
2cytokine activityGO:0051258.6ADIPOQ, NAMPT, TNF
3hormone activityGO:0051798.5RETN, ADIPOQ, LEP

Products for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources for Idiopathic Recurrent Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet