MCID: IDP041
MIFTS: 30

Idiopathic Recurrent Pericarditis malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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Sources:
31ICD10 via Orphanet, 54Orphanet
See all MalaCards sources

Aliases & Descriptions for Idiopathic Recurrent Pericarditis:

Name: Idiopathic Recurrent Pericarditis 54
 
Idiopathic Relapsing Pericarditis 54

Characteristics:

Orphanet epidemiological data:

54
idiopathic recurrent pericarditis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Orphanet54 ORPHA251307
ICD10 via Orphanet31 I09.2

Summaries for Idiopathic Recurrent Pericarditis

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MalaCards based summary: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and nondystrophic myotonia. An important gene associated with Idiopathic Recurrent Pericarditis is LEP (Leptin), and among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Adipocytokine signaling pathway. Affiliated tissues include bone, and related mouse phenotypes are adipose tissue and integument.

Related Diseases for Idiopathic Recurrent Pericarditis

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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis10.3
2nondystrophic myotonia10.3ADIPOQ, LEP
3antidepressant type abuse10.3ADIPOQ, LEP
4potato nose10.2ADIPOQ, LEP
5scleredema adultorum10.2ADIPOQ, LEP
6familial drusen10.2ADIPOQ, RETN
7patellofemoral pain syndrome10.2ADIPOQ, LEP
8hordeolum externum10.2ADIPOQ, LEP
9keratoacanthoma10.2ADIPOQ, LEP
10lymphosarcoma10.1ADIPOQ, LEP
11diabetic encephalopathy10.1ADIPOQ, LEP
12periampullary adenoma10.1ADIPOQ, LEP
13precursor b lymphoblastic lymphoma/leukemia10.1ADIPOQ, LEP
14hypertrichosis10.0ADIPOQ, LEP
15gemistocytic astrocytoma10.0ADIPOQ, LEP
16autosomal recessive secondary polycythemia not associated with vhl gene9.9MEFV, TNFRSF1A
17adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency9.9MEFV, TNFRSF1A
18tenosynovial giant cell tumor9.9ADIPOQ, LEP, RETN
19isthmus cancer9.9ADIPOQ, LEP
20corpus callosum dysgenesis cleft spasm9.9ADIPOQ, LEP, RETN
21multiple sclerosis 59.9MEFV, TNFRSF1A
22mucolipidoses9.9ADIPOQ, LEP, RETN
23short bowel syndrome9.9ADIPOQ, LEP, RETN
24familial cold-induced inflammatory syndrome 19.9MEFV, TNFRSF1A
25femoral neuropathy9.9ADIPOQ, LEP, RETN
26survival motor neuron spinal muscular atrophy9.8ADIPOQ, LEP, RETN
27acatalasemia9.8ADIPOQ, LEP, RETN
28cinca syndrome9.8MEFV, TNFRSF1A
29hypertension, essential9.8ADIPOQ, LEP, RETN
30muckle-wells syndrome9.8MEFV, TNFRSF1A
31pyloric stenosis, infantile hypertrophic, 29.8MEFV, TNFRSF1A
32nephrosclerosis9.8MEFV, TNFRSF1A
33afibrinogenemia, congenital9.8MEFV, TNFRSF1A
34angelman syndrome9.7ADIPOQ, LEP
35psoriatic arthritis9.6
36arthritis9.6
37lymphoblastic lymphoma9.6ADIPOQ, LEP, TNFRSF1A
38lower gum cancer9.6MEFV, TNFRSF1A
39benign peritoneal mesothelioma9.5MEFV, RETN, TNFRSF1A
40deafness, x-linked 59.3ADIPOQ, LEP, NAMPT, RETN
41tracheal calcification9.3ADIPOQ, LEP, NAMPT, RETN
42neonatal diabetes mellitus9.3ADIPOQ, LEP, NAMPT, RETN
43angiomatous meningioma9.3ADIPOQ, LEP, NAMPT, RETN
44diabetes mellitus, noninsulin-dependent9.3ADIPOQ, LEP, NAMPT, RETN
45hepatic adenoma, somatic9.3ADIPOQ, LEP, NAMPT, RETN
46obesity9.3ADIPOQ, LEP, NAMPT, RETN
47pure mitochondrial myopathy8.2ADIPOQ, LEP, MEFV, NAMPT, RETN, TNFRSF1A

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Symptoms & Phenotypes for Idiopathic Recurrent Pericarditis

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MGI Mouse Phenotypes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1ADIPOQ, LEP, RETN, TNFRSF1A
2MP:00107719.0ADIPOQ, LEP, MEFV, TNFRSF1A
3MP:00053978.5ADIPOQ, LEP, MEFV, NAMPT, TNFRSF1A
4MP:00053878.4ADIPOQ, LEP, MEFV, NAMPT, TNFRSF1A
5MP:00053767.9ADIPOQ, LEP, MEFV, NAMPT, RETN, TNFRSF1A
6MP:00053707.7ADIPOQ, LEP, MEFV, RETN, TNFRSF1A

Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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Drugs for Idiopathic Recurrent Pericarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Antirheumatic AgentsPhase 410627
2Interleukin 1 Receptor Antagonist ProteinPhase 496
3
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

idNameStatusNCT IDPhase
1AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)CompletedNCT02219828Phase 4
2Improvement of the Etiological Diagnosis of the PericarditisRecruitingNCT02828085

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

36
Bone

Publications for Idiopathic Recurrent Pericarditis

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Articles related to Idiopathic Recurrent Pericarditis:

(show all 23)
idTitleAuthorsYear
1
Treatment of Adults with Idiopathic Recurrent Pericarditis: Novel Use of Immunotherapy. (28079270)
2017
2
The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. (26942035)
2016
3
Usefulness of Novel Immunotherapeutic Strategies for Idiopathic Recurrent Pericarditis. (26742476)
2016
4
Anakinra: an emerging option for refractory idiopathic recurrent pericarditis: a systematic review of published evidence. (26090915)
2015
5
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. (25307995)
2014
6
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. (25165036)
2014
7
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. (25088882)
2014
8
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
9
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
10
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
11
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
12
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
13
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
14
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
15
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). (22704870)
2012
16
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
17
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
18
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
19
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
20
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
21
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
22
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
23
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ADIPOQ, LEP
28.8ADIPOQ, LEP, TNFRSF1A
38.5ADIPOQ, LEP, NAMPT, RETN

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.0ADIPOQ, LEP, RETN, TNFRSF1A
2extracellular spaceGO:00056157.6ADIPOQ, LEP, NAMPT, RETN, TNFRSF1A

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1fatty acid beta-oxidationGO:000663510.3ADIPOQ, LEP
2glucose homeostasisGO:004259310.3ADIPOQ, LEP
3glucose metabolic processGO:000600610.2ADIPOQ, LEP
4response to activityGO:001482310.2ADIPOQ, LEP
5adipose tissue developmentGO:006061210.1LEP, NAMPT
6female pregnancyGO:000756510.1LEP, NAMPT
7response to insulinGO:003286810.1LEP, RETN
8response to nutrientGO:000758410.1ADIPOQ, LEP
9positive regulation of smooth muscle cell proliferationGO:00486619.9NAMPT, RETN
10circadian rhythmGO:00076239.7ADIPOQ, LEP, NAMPT
11response to nutrient levelsGO:00316679.6ADIPOQ, LEP
12negative regulation of inflammatory responseGO:00507289.3ADIPOQ, MEFV, TNFRSF1A

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1ADIPOQ, LEP, RETN

Sources for Idiopathic Recurrent Pericarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet