MCID: IDP041
MIFTS: 36

Idiopathic Recurrent Pericarditis malady

Bone diseases, Rare diseases categories

Summaries for Idiopathic Recurrent Pericarditis

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MalaCards based summary: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds bcma and blys have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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Sources:
47Orphanet, 26ICD10 via Orphanet
See all sources

Idiopathic Recurrent Pericarditis, Aliases & Descriptions:

Name: Idiopathic Recurrent Pericarditis 47
 
Idiopathic Relapsing Pericarditis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

47
idiopathic recurrent pericarditis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 251307
ICD10 via Orphanet26 I09.2

Related Diseases for Idiopathic Recurrent Pericarditis

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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis32.0MEFV
2arthritis30.5TNFRSF1A, TNF
3psoriatic arthritis30.5TNF, TNFRSF1A
4palindromic rheumatism10.5MEFV
5erysipelas10.5MEFV
6leishmaniasis10.4TNFRSF1A
7familial cold autoinflammatory syndrome10.3MEFV, TNFRSF1A
8cinca syndrome10.3MEFV, TNFRSF1A
9muckle-wells syndrome10.3TNFRSF1A, MEFV
10relapsing fever10.3MEFV, TNFRSF1A
11blau syndrome10.2MEFV, TNF
12behcet's disease10.2TNF, MEFV
13peritonitis10.2TNF, MEFV
14rheumatic disease10.2TNF, MEFV
15spondyloarthropathy 110.2TNF, TNFRSF1A
16arthropathy10.1RETN, TNF
17graft-versus-host disease, protection against10.1TNF, TNFRSF1A
18amyloidosis10.1TNFRSF1A, MEFV
19uveitis10.1TNFRSF1A, TNF
20synovitis10.1TNFRSF1A, TNF
21liver disease10.1TNF, LEP
22monocytic leukemia10.1TNFRSF1A, TNF
23bulimia nervosa10.1LEP, RETN
24vasculitis10.1TNF, MEFV
25periodic fever, familial10.1MEFV, TNF, TNFRSF1A
26eating disorder10.1LEP, RETN
27familial mediterranean fever, ar10.0TNFRSF1A, TNF, MEFV
28hyperinsulinism10.0RETN, LEP
29fatty liver disease10.0LEP, RETN
30obstructive sleep apnea10.0LEP, ADIPOQ
31berardinelli-seip congenital lipodystrophy10.0LEP, ADIPOQ
32metabolic syndrome x10.0ADIPOQ, LEP
33acanthosis nigricans10.0LEP, ADIPOQ
34growth hormone deficiency10.0LEP, ADIPOQ
35vascular disease10.0NAMPT, RETN, ADIPOQ
36coronary artery disease10.0ADIPOQ, RETN, NAMPT
37inflammatory bowel disease10.0RETN, TNFRSF1A, TNF
38osteoarthritis10.0TNFRSF1A, RETN, TNF
39non-suppurative otitis media10.0LEP, ADIPOQ
40hyperthyroidism10.0LEP, RETN
41hypogonadism9.9ADIPOQ, LEP
42congenital heart disease9.9RETN, ADIPOQ, TNF
43hypothyroidism9.9LEP, RETN
44hypersensitivity reaction type ii disease9.9TNF, TNFRSF1A
45hypertriglyceridemia9.9LEP, ADIPOQ
46acquired generalized lipodystrophy9.8RETN, ADIPOQ, LEP
47morbid obesity9.8LEP, ADIPOQ, RETN
48hyperandrogenism9.8ADIPOQ, LEP, RETN
49lipodystrophy9.8ADIPOQ, RETN, LEP
50glucose intolerance9.8LEP, ADIPOQ, RETN

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Symptoms for Idiopathic Recurrent Pericarditis

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Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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Drug clinical trials:

Search ClinicalTrials for Idiopathic Recurrent Pericarditis

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

31
Bone

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

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Publications for Idiopathic Recurrent Pericarditis

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Articles related to Idiopathic Recurrent Pericarditis:

(show all 19)
idTitleAuthorsYear
1
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. (25165036)
2014
2
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. (25088882)
2014
3
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. (25307995)
2014
4
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
5
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
6
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
7
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
8
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
9
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
10
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
11
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). (22704870)
2012
12
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
13
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
14
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
15
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
16
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
17
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
18
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
19
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF1A
2
Show member pathways
9.6MEFV, TNF
3
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.4TNFRSF1A, TNF
49.4TNFRSF1A, TNF
59.4TNF, TNFRSF1A
6
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.4TNF, TNFRSF1A
7
Show member pathways
9.4TNFRSF1A, TNF
89.4TNFRSF1A, TNF
9
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4TNFRSF1A, TNF
10
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.4TNF, TNFRSF1A
119.4TNFRSF1A, TNF
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.4TNFRSF1A, TNF
139.4TNFRSF1A, TNF
14
Show member pathways
9.4TNFRSF1A, TNF
159.4TNF, TNFRSF1A
16
Show member pathways
9.4TNFRSF1A, TNF
17
Show member pathways
9.4TNF, TNFRSF1A
18
Show member pathways
9.3ADIPOQ, TNF
199.0ADIPOQ, LEP
20
Show member pathways
8.5ADIPOQ, TNF, LEP
21
Show member pathways
8.5ADIPOQ, TNF, LEP
228.0ADIPOQ, TNFRSF1A, TNF, LEP
23
Show member pathways
8.0LEP, TNF, TNFRSF1A, ADIPOQ
247.6LEP, TNF, NAMPT, ADIPOQ, RETN
25
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
7.1RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1bcma439.7TNF, TNFRSF1A
2blys439.6TNF, TNFRSF1A
3actinomycin439.5TNFRSF1A, TNF
4clenbuterol43 1210.4LEP, TNF
52-arachidonoylglycerol43 2810.3LEP, ADIPOQ
6rimonabant43 28 1211.3LEP, ADIPOQ
7sibutramine43 1210.2LEP, ADIPOQ
8atorvastatin43 49 28 24 1213.2RETN, ADIPOQ, TNF
9infliximab43 49 1211.2TNF, TNFRSF1A, ADIPOQ
10stavudine43 1210.2LEP, ADIPOQ
11tab-1439.1TNF, TNFRSF1A
12simvastatin43 49 59 28 24 1214.1ADIPOQ, TNFRSF1A, TNF
13topiramate43 49 24 1212.0ADIPOQ, LEP
14thiazolidinedione439.0LEP, ADIPOQ, RETN
1511beta-hydroxysteroid439.0RETN, ADIPOQ, LEP
16c-peptide438.9RETN, ADIPOQ, LEP
17dhea438.9LEP, ADIPOQ, RETN
18acipimox43 289.9LEP, ADIPOQ
19uric acid43 249.9LEP, ADIPOQ, RETN
20thyroxine43 249.8LEP, ADIPOQ, RETN
21troglitazone43 28 59 1211.8LEP, TNF, ADIPOQ
22actinomycin d438.7TNF, TNFRSF1A, ADIPOQ, RETN
23metformin43 49 1210.6RETN, ADIPOQ, NAMPT, LEP
24vitamin a43 24 1210.6RETN, ADIPOQ, LEP
25fatty acid438.5LEP, NAMPT, ADIPOQ, RETN
268-isoprostane438.5LEP, TNF, ADIPOQ, RETN
27fenofibrate43 49 1210.5LEP, TNF, ADIPOQ, RETN
28cycloheximide438.5LEP, TNF, TNFRSF1A, RETN
29p003438.5RETN, ADIPOQ, TNFRSF1A, LEP
30p002438.5LEP, TNFRSF1A, ADIPOQ, RETN
31norepinephrine43 24 1210.4RETN, ADIPOQ, TNFRSF1A, LEP
32ly294002438.4LEP, TNF, ADIPOQ, RETN
33etanercept43 49 1210.4ADIPOQ, TNFRSF1A, TNF, LEP
34endotoxin438.4MEFV, RETN, ADIPOQ, TNFRSF1A, TNF
35estradiol43 24 1210.4RETN, ADIPOQ, TNFRSF1A, LEP
36prostacyclin438.4LEP, TNF, TNFRSF1A, ADIPOQ
37methotrexate49 43 1210.4ADIPOQ, TNFRSF1A, TNF, LEP
38testosterone43 59 24 1211.3LEP, TNFRSF1A, ADIPOQ, RETN
39h2o2438.3ADIPOQ, TNFRSF1A, TNF, LEP
40vegf438.2LEP, TNF, TNFRSF1A, RETN
41pioglitazone28 43 49 1211.1LEP, TNF, NAMPT, ADIPOQ, RETN
42rosiglitazone28 43 49 24 1212.1LEP, TNF, NAMPT, ADIPOQ, RETN
43fibrinogen438.1LEP, TNF, NAMPT, ADIPOQ, RETN
44creatinine438.1LEP, TNFRSF1A, NAMPT, ADIPOQ, RETN
45cholesterol43 28 24 1211.1LEP, TNFRSF1A, NAMPT, ADIPOQ, RETN
46phosphatidylinositol438.0LEP, TNFRSF1A, NAMPT, ADIPOQ, RETN
47glucose438.0LEP, TNFRSF1A, NAMPT, ADIPOQ, RETN
48nash438.0RETN, ADIPOQ, TNFRSF1A, TNF, LEP
49dexamethasone43 49 28 1210.6LEP, TNF, TNFRSF1A, NAMPT, ADIPOQ, RETN
50lipid437.5LEP, TNF, TNFRSF1A, NAMPT, ADIPOQ, RETN

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.5TNF, TNFRSF1A, ADIPOQ
2extracellular regionGO:00055768.0ADIPOQ, TNFRSF1A, TNF, LEP
3extracellular spaceGO:00056157.0RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:00508069.8TNF, RETN
2negative regulation of interleukin-6 productionGO:00327159.7TNFRSF1A, TNF
3positive regulation of smooth muscle cell proliferationGO:00486619.7TNF, RETN
4extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7TNFRSF1A, TNF
5response to activityGO:00148239.6ADIPOQ, TNF
6response to mechanical stimulusGO:00096129.6RETN, TNF
7negative regulation of fat cell differentiationGO:00455999.6ADIPOQ, TNF
8intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.5TNF, TNFRSF1A
9adipose tissue developmentGO:00606129.5LEP, NAMPT
10leukocyte tethering or rollingGO:00509019.5LEP, TNF
11positive regulation of cytokine productionGO:00018199.4TNF, LEP
12response to insulinGO:00328689.3RETN, LEP
13response to ethanolGO:00454719.3ADIPOQ, TNFRSF1A
14response to glucocorticoidGO:00513849.3TNF, ADIPOQ
15negative regulation of gene expressionGO:00106299.3TNF, TNFRSF1A
16inflammatory responseGO:00069549.3TNF, TNFRSF1A, MEFV
17negative regulation of inflammatory responseGO:00507289.3TNFRSF1A, ADIPOQ, MEFV
18circadian rhythmGO:00076239.2ADIPOQ, LEP
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1ADIPOQ, TNFRSF1A, TNF
20glucose metabolic processGO:00060068.8ADIPOQ, TNF, LEP
21regulation of insulin secretionGO:00507968.8TNF, LEP
22response to hypoxiaGO:00016668.3ADIPOQ, TNFRSF1A, TNF, LEP

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.4TNFRSF1A, TNF
2cytokine activityGO:00051258.6ADIPOQ, NAMPT, TNF
3hormone activityGO:00051798.5RETN, ADIPOQ, LEP

Products for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources for Idiopathic Recurrent Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet