MCID: IDP041
MIFTS: 34

Idiopathic Recurrent Pericarditis malady

Bone diseases category

Summaries for Idiopathic Recurrent Pericarditis

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MalaCards: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are Signal transduction JNK pathway and TNF receptor signaling pathway. The compounds estradiol and p003 have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
idiopathic recurrent pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

idiopathic recurrent pericarditis 48
idiopathic relapsing pericarditis 48


External Ids:

ICD10 via Orphanet26 E85.0

Related Diseases for Idiopathic Recurrent Pericarditis

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17GeneCards, 18GeneDecks
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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis31.0MEFV
2arthritis30.1TNFRSF1A, TNF
3psoriatic arthritis30.1TNF, TNFRSF1A
4palindromic rheumatism10.0MEFV
5viral hepatitis10.0TNFRSF1A
6crohn's disease10.0TNF
7erysipelas10.0MEFV
8alzheimer's disease10.0TNFRSF1A
9ulcerative colitis10.0TNF
10primary hyperoxaluria10.0TNF
11neutropenia10.0TNFRSF1A
12pyoderma gangrenosum10.0MEFV
13acute pancreatitis10.0RETN
14endometriosis10.0ADIPOQ
15paracoccidioidomycosis10.0TNFRSF1A
16proteinuria10.0ADIPOQ
17myeloma10.0TNFRSF1A
18pleurisy10.0MEFV
19peritonitis10.0MEFV, TNF
20familial cold autoinflammatory syndrome10.0TNFRSF1A, MEFV
21psoriasis10.0TNF, TNFRSF1A
22severe pre-eclampsia10.0LEP
23chronic infantile neurological cutaneous articular syndrome10.0TNFRSF1A, MEFV
24muckle-wells syndrome10.0MEFV, TNFRSF1A
25narcolepsy10.0LEP
26amyloidosis10.0MEFV, TNFRSF1A
27relapsing fever10.0TNFRSF1A, MEFV
28blau syndrome10.0MEFV, TNF
29multiple sclerosis10.0TNFRSF1A, TNF
30asthma10.0ADIPOQ, TNF
31synovitis10.0TNF, TNFRSF1A
32hepatitis b10.0ADIPOQ, TNFRSF1A
33acute myocardial infarction10.0RETN, MEFV
34vasculitis10.0MEFV, TNF
35ankylosing spondylitis10.0TNFRSF1A, TNF
36myocardial infarction10.0RETN, ADIPOQ
37behcet's disease10.0TNF, MEFV
38brucellosis10.0MEFV
39hypercholesterolemia10.0ADIPOQ, RETN
40choriocarcinoma10.0LEP
41stomach cancer10.0ADIPOQ, TNFRSF1A
42tumor necrosis factor receptor-associated periodic syndrome10.0TNFRSF1A, TNF, MEFV
43familial mediterranean fever10.0TNFRSF1A, TNF, MEFV
44galactosemia10.0LEP, TNF
45rheumatic disease10.0TNF, MEFV
46growth hormone deficiency10.0LEP, ADIPOQ
47graft versus host disease10.0TNFRSF1A, TNF
48hypertriglyceridemia10.0LEP, ADIPOQ
49hypogonadism10.0ADIPOQ, LEP
50bulimia nervosa10.0LEP, RETN

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Clinical Features for Idiopathic Recurrent Pericarditis

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Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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32MalaCards
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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

32
Bone

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Idiopathic Recurrent Pericarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2RETN
2MP:00020069.3TNF, TNFRSF1A
3MP:00053799.2NAMPT, TNF, TNFRSF1A
4MP:00107717.8TNFRSF1A, TNF, MEFV, LEP, ADIPOQ
5MP:00053707.5ADIPOQ, TNFRSF1A, TNF, MEFV, RETN, LEP
6MP:00053977.4TNFRSF1A, TNF, MEFV, NAMPT, LEP, ADIPOQ
7MP:00053877.4TNFRSF1A, TNF, MEFV, NAMPT, LEP, ADIPOQ
8MP:00107687.3TNF, MEFV, NAMPT, LEP, ADIPOQ, TNFRSF1A
9MP:00053847.2TNFRSF1A, TNF, MEFV, NAMPT, LEP, ADIPOQ
10MP:00053766.9TNFRSF1A, TNF, MEFV, RETN, NAMPT, LEP

Publications for Idiopathic Recurrent Pericarditis

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Genetic Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 52R&D Systems, 29KEGG
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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Signal transduction JNK pathway
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9.6TNF, TNFRSF1A
29.6TNFRSF1A, TNF
3
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9.6TNFRSF1A, TNF
4
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.6TNF, TNFRSF1A
59.6TNF, TNFRSF1A
69.6TNFRSF1A, TNF
79.6TNFRSF1A, TNF
8
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9.6TNF, TNFRSF1A
99.6TNFRSF1A, TNF
10
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9.6TNFRSF1A, TNF
119.1ADIPOQ, RETN
129.1RETN, ADIPOQ
138.2TNFRSF1A, TNF, LEP, ADIPOQ
14
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8.2TNFRSF1A, TNF, LEP, ADIPOQ
158.0RETN, NAMPT, LEP, ADIPOQ
16
Hide members
7.1ADIPOQ, LEP, NAMPT, RETN, TNF, TNFRSF1A

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.4TNFRSF1A
2p0034410.4RETN
3glucose4410.3NAMPT
4fatty acid4410.3NAMPT
5norepinephrine44 11 2411.9TNFRSF1A, RETN
6bcma449.9TNFRSF1A, TNF
7blys449.9TNF, TNFRSF1A
8actinomycin449.8TNFRSF1A, TNF
9tab-1449.8TNF, TNFRSF1A
10clenbuterol44 1110.7TNF, LEP
112-arachidonoylglycerol44 2810.4ADIPOQ, LEP
12rimonabant44 28 1111.3LEP, ADIPOQ
13sibutramine44 1110.3LEP, ADIPOQ
14stavudine44 1110.3LEP, ADIPOQ
15infliximab44 49 1111.2TNF, TNFRSF1A, ADIPOQ
16topiramate44 11 2411.1LEP, ADIPOQ
17glimepiride44 49 1111.1ADIPOQ, RETN
18acipimox44 2810.1LEP, ADIPOQ
19simvastatin44 49 59 28 11 2414.1TNF, ADIPOQ, TNFRSF1A
20oxyntomodulin44 5910.0ADIPOQ, LEP
21atorvastatin44 49 28 11 2413.0TNF, RETN, ADIPOQ
22thiazolidinedione448.9ADIPOQ, LEP, RETN
23troglitazone44 28 59 1111.9ADIPOQ, LEP, TNF
2411beta-hydroxysteroid448.9ADIPOQ, LEP, RETN
25c-peptide448.9LEP, RETN, ADIPOQ
26dhea448.9RETN, LEP, ADIPOQ
27thyroxine44 249.8ADIPOQ, LEP, RETN
28actinomycin d448.6RETN, ADIPOQ, TNF, TNFRSF1A
29etanercept44 49 1110.6TNFRSF1A, TNF, LEP, ADIPOQ
30prostacyclin448.6ADIPOQ, LEP, TNF, TNFRSF1A
31methotrexate44 49 1110.6TNF, ADIPOQ, LEP, TNFRSF1A
32p002448.5ADIPOQ, LEP, RETN, TNFRSF1A
338-isoprostane448.5RETN, TNF, ADIPOQ, LEP
34fenofibrate44 49 1110.5RETN, TNF, ADIPOQ, LEP
35ly294002448.4ADIPOQ, LEP, RETN, TNF
36metformin44 49 1110.4LEP, NAMPT, RETN, ADIPOQ
37vitamin a44 11 2410.4ADIPOQ, LEP, RETN
38h2o2448.4LEP, ADIPOQ, TNF, TNFRSF1A
39endotoxin448.3MEFV, ADIPOQ, TNFRSF1A, TNF, RETN
40testosterone44 59 11 2411.3RETN, TNFRSF1A, ADIPOQ, LEP
41vegf448.2TNFRSF1A, TNF, LEP, RETN
42nash448.1LEP, ADIPOQ, RETN, TNF, TNFRSF1A
43creatinine448.0RETN, TNFRSF1A, NAMPT, ADIPOQ, LEP
44cholesterol44 28 11 2411.0TNFRSF1A, RETN, NAMPT, LEP, ADIPOQ
45pioglitazone44 49 28 1111.0TNF, NAMPT, RETN, LEP, ADIPOQ
46rosiglitazone44 49 28 11 2412.0ADIPOQ, RETN, NAMPT, LEP, TNF
47phosphatidylinositol448.0LEP, RETN, NAMPT, TNFRSF1A, ADIPOQ
48fibrinogen448.0TNF, ADIPOQ, RETN, NAMPT, LEP
49dexamethasone44 49 28 1110.6ADIPOQ, LEP, RETN, NAMPT, TNF, TNFRSF1A
50lipid447.5LEP, NAMPT, RETN, TNF, TNFRSF1A, ADIPOQ

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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16Gene Ontology
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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8ADIPOQ, TNF, TNFRSF1A
2extracellular spaceGO:0056157.5ADIPOQ, LEP, RETN, TNF, TNFRSF1A
3extracellular regionGO:0055767.3TNFRSF1A, TNF, RETN, LEP, ADIPOQ

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.8TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNF, TNFRSF1A
3leukocyte tethering or rollingGO:0509019.6LEP, TNF
4positive regulation of cytokine productionGO:0018199.6TNF, LEP
5adipose tissue developmentGO:0606129.5NAMPT, LEP
6response to insulin stimulusGO:0328689.3LEP, RETN
7response to activityGO:0148239.3ADIPOQ, TNF
8negative regulation of fat cell differentiationGO:0455999.2TNF, ADIPOQ
9negative regulation of inflammatory responseGO:0507289.1ADIPOQ, MEFV, TNFRSF1A
10inflammatory responseGO:0069549.1MEFV, TNF, TNFRSF1A
11positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0ADIPOQ, TNF, TNFRSF1A
12glucose metabolic processGO:0060068.8TNF, LEP, ADIPOQ
13circadian rhythmGO:0076238.7ADIPOQ, LEP
14response to hypoxiaGO:0016668.4ADIPOQ, LEP, TNF, TNFRSF1A

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7ADIPOQ, NAMPT, TNF
2hormone activityGO:0051798.2ADIPOQ, LEP, RETN

Products for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources for Idiopathic Recurrent Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet