MCID: IDP041
MIFTS: 36

Idiopathic Recurrent Pericarditis malady

Bone diseases, Rare diseases categories

Aliases & Classifications for Idiopathic Recurrent Pericarditis

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Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Idiopathic Recurrent Pericarditis:

Name: Idiopathic Recurrent Pericarditis 48
 
Idiopathic Relapsing Pericarditis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
idiopathic recurrent pericarditis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet48 251307
ICD10 via Orphanet26 I09.2

Summaries for Idiopathic Recurrent Pericarditis

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MalaCards based summary: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds bcma and blys have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are reproductive system and tumorigenesis.

Related Diseases for Idiopathic Recurrent Pericarditis

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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis32.0MEFV
2arthritis30.5TNFRSF1A, TNF
3psoriatic arthritis30.5TNF, TNFRSF1A
4palindromic rheumatism10.5MEFV
5erysipelas10.5MEFV
6leishmaniasis10.4TNFRSF1A
7familial cold autoinflammatory syndrome10.3MEFV, TNFRSF1A
8cinca syndrome10.3MEFV, TNFRSF1A
9muckle-wells syndrome10.3TNFRSF1A, MEFV
10relapsing fever10.3MEFV, TNFRSF1A
11blau syndrome10.2MEFV, TNF
12behcet's disease10.2TNF, MEFV
13peritonitis10.2TNF, MEFV
14rheumatic disease10.2TNF, MEFV
15spondyloarthropathy 110.2TNF, TNFRSF1A
16arthropathy10.1RETN, TNF
17graft-versus-host disease, protection against10.1TNF, TNFRSF1A
18amyloidosis10.1TNFRSF1A, MEFV
19uveitis10.1TNFRSF1A, TNF
20synovitis10.1TNFRSF1A, TNF
21liver disease10.1TNF, LEP
22monocytic leukemia10.1TNFRSF1A, TNF
23bulimia nervosa10.1LEP, RETN
24vasculitis10.1TNF, MEFV
25periodic fever, familial10.1MEFV, TNF, TNFRSF1A
26eating disorder10.1LEP, RETN
27familial mediterranean fever, ar10.0TNFRSF1A, TNF, MEFV
28hyperinsulinism10.0RETN, LEP
29fatty liver disease10.0LEP, RETN
30obstructive sleep apnea10.0LEP, ADIPOQ
31berardinelli-seip congenital lipodystrophy10.0LEP, ADIPOQ
32metabolic syndrome x10.0ADIPOQ, LEP
33acanthosis nigricans10.0LEP, ADIPOQ
34growth hormone deficiency10.0LEP, ADIPOQ
35vascular disease10.0NAMPT, RETN, ADIPOQ
36coronary artery disease10.0ADIPOQ, RETN, NAMPT
37inflammatory bowel disease10.0RETN, TNFRSF1A, TNF
38osteoarthritis10.0TNFRSF1A, RETN, TNF
39non-suppurative otitis media10.0LEP, ADIPOQ
40hyperthyroidism10.0LEP, RETN
41hypogonadism9.9ADIPOQ, LEP
42congenital heart disease9.9RETN, ADIPOQ, TNF
43hypothyroidism9.9LEP, RETN
44hypersensitivity reaction type ii disease9.9TNF, TNFRSF1A
45hypertriglyceridemia9.9LEP, ADIPOQ
46acquired generalized lipodystrophy9.8RETN, ADIPOQ, LEP
47morbid obesity9.8LEP, ADIPOQ, RETN
48hyperandrogenism9.8ADIPOQ, LEP, RETN
49lipodystrophy9.8ADIPOQ, RETN, LEP
50glucose intolerance9.8LEP, ADIPOQ, RETN

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Symptoms for Idiopathic Recurrent Pericarditis

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Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

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Drug clinical trials:

Search ClinicalTrials for Idiopathic Recurrent Pericarditis

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

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Anatomical Context for Idiopathic Recurrent Pericarditis

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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

31
Bone

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

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Publications for Idiopathic Recurrent Pericarditis

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Articles related to Idiopathic Recurrent Pericarditis:

(show all 19)
idTitleAuthorsYear
1
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. (25165036)
2014
2
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. (25088882)
2014
3
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. (25307995)
2014
4
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
5
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
6
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
7
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
8
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
9
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
10
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
11
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). (22704870)
2012
12
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
13
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
14
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
15
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
16
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
17
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
18
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
19
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Variations for Idiopathic Recurrent Pericarditis

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Expression for genes affiliated with Idiopathic Recurrent Pericarditis

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Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFRSF1A
2
Show member pathways
9.6TNF, MEFV
3
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.4TNFRSF1A, TNF
49.4TNFRSF1A, TNF
59.4TNFRSF1A, TNF
6
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway59
9.4TNFRSF1A, TNF
7
Show member pathways
9.4TNFRSF1A, TNF
89.4TNFRSF1A, TNF
9
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.4TNFRSF1A, TNF
10
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
9.4TNF, TNFRSF1A
119.4TNF, TNFRSF1A
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways59
9.4TNF, TNFRSF1A
139.4TNFRSF1A, TNF
14
Show member pathways
9.4TNFRSF1A, TNF
159.4TNFRSF1A, TNF
16
Show member pathways
9.4TNFRSF1A, TNF
17
Show member pathways
9.4TNF, TNFRSF1A
18
Show member pathways
9.3TNF, ADIPOQ
199.0ADIPOQ, LEP
20
Show member pathways
8.5TNF, LEP, ADIPOQ
21
Show member pathways
8.5ADIPOQ, TNF, LEP
228.0TNF, TNFRSF1A, LEP, ADIPOQ
23
Show member pathways
8.0ADIPOQ, TNFRSF1A, TNF, LEP
247.6LEP, TNF, RETN, NAMPT, ADIPOQ
25
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
7.1TNFRSF1A, NAMPT, ADIPOQ, RETN, TNF, LEP

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1bcma449.7TNF, TNFRSF1A
2blys449.6TNFRSF1A, TNF
3actinomycin449.5TNFRSF1A, TNF
4clenbuterol44 1110.4TNF, LEP
5tab-1449.3TNFRSF1A, TNF
62-arachidonoylglycerol44 2810.3ADIPOQ, LEP
7rimonabant44 28 1111.3ADIPOQ, LEP
8stavudine44 1110.2ADIPOQ, LEP
9atorvastatin44 50 28 24 1113.2TNF, ADIPOQ, RETN
10infliximab44 50 1111.2TNFRSF1A, ADIPOQ, TNF
11sibutramine44 1110.2ADIPOQ, LEP
12simvastatin44 50 60 28 24 1114.1TNF, ADIPOQ, TNFRSF1A
13topiramate44 50 24 1112.0LEP, ADIPOQ
14thiazolidinedione449.0LEP, ADIPOQ, RETN
1511beta-hydroxysteroid449.0ADIPOQ, LEP, RETN
16c-peptide448.9ADIPOQ, RETN, LEP
17dhea448.9LEP, ADIPOQ, RETN
18uric acid44 249.9LEP, RETN, ADIPOQ
19thyroxine44 249.8ADIPOQ, LEP, RETN
20troglitazone44 28 60 1111.8TNF, LEP, ADIPOQ
21acipimox44 289.7LEP, ADIPOQ
22actinomycin d448.7RETN, ADIPOQ, TNFRSF1A, TNF
23metformin44 50 1110.6LEP, RETN, ADIPOQ, NAMPT
24vitamin a44 24 1110.6ADIPOQ, LEP, RETN
25fatty acid448.5RETN, ADIPOQ, LEP, NAMPT
268-isoprostane448.5LEP, TNF, RETN, ADIPOQ
27fenofibrate44 50 1110.5LEP, ADIPOQ, TNF, RETN
28cycloheximide448.5TNFRSF1A, LEP, RETN, TNF
29p003448.5ADIPOQ, TNFRSF1A, LEP, RETN
30p002448.5RETN, LEP, TNFRSF1A, ADIPOQ
31norepinephrine44 24 1110.4TNFRSF1A, LEP, RETN, ADIPOQ
32ly294002448.4RETN, ADIPOQ, TNF, LEP
33etanercept44 50 1110.4ADIPOQ, LEP, TNF, TNFRSF1A
34endotoxin448.4RETN, MEFV, ADIPOQ, TNFRSF1A, TNF
35estradiol44 24 1110.4TNFRSF1A, RETN, ADIPOQ, LEP
36prostacyclin448.4ADIPOQ, TNFRSF1A, LEP, TNF
37methotrexate50 44 1110.4LEP, TNF, TNFRSF1A, ADIPOQ
38testosterone44 60 24 1111.3TNFRSF1A, ADIPOQ, LEP, RETN
39h2o2448.3LEP, TNF, ADIPOQ, TNFRSF1A
40vegf448.2TNFRSF1A, TNF, LEP, RETN
41pioglitazone28 44 50 1111.1LEP, RETN, ADIPOQ, NAMPT, TNF
42rosiglitazone28 44 50 24 1112.1RETN, NAMPT, TNF, ADIPOQ, LEP
43fibrinogen448.1NAMPT, RETN, ADIPOQ, TNF, LEP
44creatinine448.1LEP, ADIPOQ, RETN, TNFRSF1A, NAMPT
45cholesterol44 28 24 1111.1RETN, LEP, TNFRSF1A, NAMPT, ADIPOQ
46phosphatidylinositol448.0NAMPT, TNFRSF1A, ADIPOQ, LEP, RETN
47glucose448.0LEP, RETN, ADIPOQ, NAMPT, TNFRSF1A
48nash448.0LEP, RETN, TNF, TNFRSF1A, ADIPOQ
49dexamethasone44 50 28 1110.6NAMPT, TNF, TNFRSF1A, RETN, ADIPOQ, LEP
50lipid447.5RETN, ADIPOQ, LEP, NAMPT, TNFRSF1A, TNF

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

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Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.5TNF, TNFRSF1A, ADIPOQ
2extracellular regionGO:00055768.0ADIPOQ, TNFRSF1A, TNF, LEP
3extracellular spaceGO:00056157.0RETN, ADIPOQ, NAMPT, TNFRSF1A, TNF, LEP

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:00508069.8TNF, RETN
2negative regulation of interleukin-6 productionGO:00327159.7TNFRSF1A, TNF
3positive regulation of smooth muscle cell proliferationGO:00486619.7TNF, RETN
4extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7TNFRSF1A, TNF
5response to activityGO:00148239.6ADIPOQ, TNF
6response to mechanical stimulusGO:00096129.6RETN, TNF
7negative regulation of fat cell differentiationGO:00455999.6ADIPOQ, TNF
8intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.5TNF, TNFRSF1A
9adipose tissue developmentGO:00606129.5LEP, NAMPT
10leukocyte tethering or rollingGO:00509019.5LEP, TNF
11positive regulation of cytokine productionGO:00018199.4TNF, LEP
12response to insulinGO:00328689.3RETN, LEP
13response to ethanolGO:00454719.3ADIPOQ, TNFRSF1A
14response to glucocorticoidGO:00513849.3TNF, ADIPOQ
15negative regulation of gene expressionGO:00106299.3TNF, TNFRSF1A
16inflammatory responseGO:00069549.3TNF, TNFRSF1A, MEFV
17negative regulation of inflammatory responseGO:00507289.3TNFRSF1A, ADIPOQ, MEFV
18circadian rhythmGO:00076239.2ADIPOQ, LEP
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1ADIPOQ, TNFRSF1A, TNF
20glucose metabolic processGO:00060068.8ADIPOQ, TNF, LEP
21regulation of insulin secretionGO:00507968.8TNF, LEP
22response to hypoxiaGO:00016668.3ADIPOQ, TNFRSF1A, TNF, LEP

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.4TNFRSF1A, TNF
2cytokine activityGO:00051258.6ADIPOQ, NAMPT, TNF
3hormone activityGO:00051798.5RETN, ADIPOQ, LEP

Sources for Idiopathic Recurrent Pericarditis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet