MCID: IDP041
MIFTS: 30

Idiopathic Recurrent Pericarditis malady

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Recurrent Pericarditis

Aliases & Descriptions for Idiopathic Recurrent Pericarditis:

Name: Idiopathic Recurrent Pericarditis 56
Idiopathic Relapsing Pericarditis 56

Characteristics:

Orphanet epidemiological data:

56
idiopathic recurrent pericarditis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 56 ORPHA251307
ICD10 via Orphanet 34 I09.2

Summaries for Idiopathic Recurrent Pericarditis

MalaCards based summary : Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to pericarditis and nystagmus, congenital motor, autosomal recessive. An important gene associated with Idiopathic Recurrent Pericarditis is LEP (Leptin), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Circadian rythm related genes. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Idiopathic Recurrent Pericarditis

Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 pericarditis 30.3 ADIPOQ NAMPT RETN
2 nystagmus, congenital motor, autosomal recessive 10.2 ADIPOQ LEP
3 leg dermatosis 10.1 ADIPOQ LEP
4 hyperlipoproteinemia type iv 10.1 ADIPOQ LEP
5 neurogenic arthropathy 10.1 ADIPOQ LEP
6 exophthalmic ophthalmoplegia 10.1 ADIPOQ LEP
7 cholesteatoma 10.1 ADIPOQ LEP
8 limb ischemia 10.1 ADIPOQ LEP
9 diabetic encephalopathy 10.0 ADIPOQ LEP
10 bile duct mucoepidermoid carcinoma 10.0 LEP RETN
11 chronic tic disorder 10.0 ADIPOQ LEP
12 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 10.0 MEFV TNFRSF1A
13 spondylocostal dysostosis-hypospadias-intellectual disability syndrome 10.0 MEFV TNFRSF1A
14 acrocephalopolydactyly 10.0 ADIPOQ LEP RETN
15 candidiasis, familial, 4, autosomal recessive 10.0 MEFV TNFRSF1A
16 mucinoses 10.0 ADIPOQ LEP RETN
17 not otherwise specified 3-mga-uria type 10.0 ADIPOQ LEP RETN
18 lipomatosis 10.0 ADIPOQ LEP
19 cortical blindness mental retardation polydactyly 10.0 ADIPOQ LEP RETN
20 muckle-wells syndrome 10.0 MEFV TNFRSF1A
21 cataract 20, multiple types 10.0 ADIPOQ LEP RETN
22 mucopolysaccharidosis iii 10.0 ADIPOQ LEP RETN
23 thymus clear cell carcinoma 10.0 ADIPOQ LEP RETN
24 mechanical lagophthalmos 10.0 MEFV TNFRSF1A
25 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.0 ADIPOQ LEP RETN
26 peroneal neuropathy 10.0 ADIPOQ LEP RETN
27 kidney leiomyosarcoma 10.0 MEFV TNFRSF1A
28 blind loop syndrome 10.0 ADIPOQ LEP RETN
29 body dysmorphic disorder 10.0 ADIPOQ LEP RETN
30 cinca syndrome 10.0 MEFV TNFRSF1A
31 mental retardation, autosomal dominant 22 10.0 MEFV TNFRSF1A
32 pyloric stenosis, infantile hypertrophic, 2 10.0 MEFV TNFRSF1A
33 hypertension, essential 10.0 ADIPOQ LEP RETN
34 wilkes stevenson syndrome 9.9 MEFV TNFRSF1A
35 patau syndrome 9.9 MEFV TNFRSF1A
36 pancreas lymphoma 9.9 MEFV TNFRSF1A
37 van maldergem syndrome 2 9.9 MEFV TNFRSF1A
38 lymphoid leukemia 9.8 ADIPOQ LEP TNFRSF1A
39 antidepressant type abuse 9.7 ADIPOQ LEP NAMPT RETN
40 adrenal adenoma 9.7 ADIPOQ LEP NAMPT RETN
41 maturity-onset diabetes of the young 6 9.7 ADIPOQ LEP NAMPT RETN
42 von hippel-lindau syndrome 9.7 ADIPOQ LEP NAMPT RETN
43 diabetes mellitus, insulin-dependent, 20 9.7 ADIPOQ LEP RETN
44 psoriatic arthritis 9.6
45 arthritis 9.6
46 malignant perineurioma 9.2 ADIPOQ LEP MEFV NAMPT RETN TNFRSF1A

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to Idiopathic Recurrent Pericarditis

Symptoms & Phenotypes for Idiopathic Recurrent Pericarditis

MGI Mouse Phenotypes related to Idiopathic Recurrent Pericarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 LEP MEFV NAMPT TNFRSF1A ADIPOQ
2 homeostasis/metabolism MP:0005376 9.63 LEP MEFV NAMPT RETN TNFRSF1A ADIPOQ
3 adipose tissue MP:0005375 9.62 LEP RETN TNFRSF1A ADIPOQ
4 immune system MP:0005387 9.43 LEP MEFV NAMPT RETN TNFRSF1A ADIPOQ
5 liver/biliary system MP:0005370 9.02 MEFV RETN TNFRSF1A ADIPOQ LEP

Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

Drugs for Idiopathic Recurrent Pericarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 4
2 Antirheumatic Agents Phase 4
3
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


id Name Status NCT ID Phase
1 AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP) Completed NCT02219828 Phase 4
2 Improvement of the Etiological Diagnosis of the Pericarditis Recruiting NCT02828085

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

Anatomical Context for Idiopathic Recurrent Pericarditis

MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

39
Bone

Publications for Idiopathic Recurrent Pericarditis

Articles related to Idiopathic Recurrent Pericarditis:

(show all 23)
id Title Authors Year
1
Treatment of Adults with Idiopathic Recurrent Pericarditis: Novel Use of Immunotherapy. ( 28079270 )
2017
2
The Use of IL-1 Receptor Antagonist (Anakinra) in Idiopathic Recurrent Pericarditis: A Narrative Review. ( 26942035 )
2016
3
Usefulness of Novel Immunotherapeutic Strategies for Idiopathic Recurrent Pericarditis. ( 26742476 )
2016
4
Anakinra: an emerging option for refractory idiopathic recurrent pericarditis: a systematic review of published evidence. ( 26090915 )
2015
5
Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. ( 25165036 )
2014
6
Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis. ( 25088882 )
2014
7
Idiopathic recurrent pericarditis as an immune-mediated disease: current insights into pathogenesis and emerging treatment options. ( 25307995 )
2014
8
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. ( 23052671 )
2013
9
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). ( 23463131 )
2013
10
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. ( 23981280 )
2013
11
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. ( 23137677 )
2013
12
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. ( 21170606 )
2013
13
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). ( 23711245 )
2013
14
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). ( 22704870 )
2012
15
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. ( 22155373 )
2012
16
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. ( 20074469 )
2009
17
Idiopathic recurrent pericarditis: searching for Ariadne's thread. ( 19767277 )
2009
18
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. ( 19644862 )
2009
19
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? ( 19116906 )
2009
20
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. ( 17826391 )
2007
21
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. ( 12690925 )
2003
22
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. ( 14224691 )
1965
23
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. ( 14361444 )
1955

Variations for Idiopathic Recurrent Pericarditis

Expression for Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for Idiopathic Recurrent Pericarditis

GO Terms for Idiopathic Recurrent Pericarditis

Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 ADIPOQ LEP NAMPT RETN TNFRSF1A
2 extracellular space GO:0005615 9.02 ADIPOQ LEP NAMPT RETN TNFRSF1A

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 9.51 ADIPOQ LEP
2 female pregnancy GO:0007565 9.49 LEP NAMPT
3 response to nutrient GO:0007584 9.48 ADIPOQ LEP
4 response to insulin GO:0032868 9.46 LEP RETN
5 glucose metabolic process GO:0006006 9.43 ADIPOQ LEP
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.4 NAMPT RETN
7 response to nutrient levels GO:0031667 9.37 ADIPOQ LEP
8 fatty acid beta-oxidation GO:0006635 9.32 ADIPOQ LEP
9 response to activity GO:0014823 9.26 ADIPOQ LEP
10 adipose tissue development GO:0060612 9.16 LEP NAMPT
11 circadian rhythm GO:0007623 9.13 ADIPOQ LEP NAMPT
12 negative regulation of inflammatory response GO:0050728 8.8 ADIPOQ MEFV TNFRSF1A

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 ADIPOQ LEP RETN

Sources for Idiopathic Recurrent Pericarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....