MCID: IDP041
MIFTS: 33

Idiopathic Recurrent Pericarditis malady

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Summaries for Idiopathic Recurrent Pericarditis

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33MalaCards
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MalaCards: Idiopathic Recurrent Pericarditis, also known as idiopathic relapsing pericarditis, is related to arthritis and psoriatic arthritis. An important gene associated with Idiopathic Recurrent Pericarditis is MEFV (Mediterranean fever), and among its related pathways are Signal transduction JNK pathway and TNF receptor signaling pathway. The compounds estradiol and p003 have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Idiopathic Recurrent Pericarditis

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
idiopathic recurrent pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

idiopathic recurrent pericarditis 49
idiopathic relapsing pericarditis 49


External Ids:

ICD10 via Orphanet26 E85.0

Related Diseases for Idiopathic Recurrent Pericarditis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Idiopathic Recurrent Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.2TNFRSF1A, TNF
2psoriatic arthritis30.2TNF, TNFRSF1A
3n syndrome10.1
4palindromic rheumatism10.0MEFV
5pericarditis10.0MEFV
6viral hepatitis10.0TNFRSF1A
7crohn's disease10.0TNF
8erysipelas10.0MEFV
9alzheimer's disease10.0TNFRSF1A
10ulcerative colitis10.0TNF
11primary hyperoxaluria10.0TNF
12neutropenia10.0TNFRSF1A
13pyoderma gangrenosum10.0MEFV
14acute pancreatitis10.0RETN
15endometriosis10.0ADIPOQ
16paracoccidioidomycosis10.0TNFRSF1A
17proteinuria10.0ADIPOQ
18myeloma10.0TNFRSF1A
19pleurisy10.0MEFV
20peritonitis10.0MEFV, TNF
21familial cold autoinflammatory syndrome10.0TNFRSF1A, MEFV
22psoriasis10.0TNF, TNFRSF1A
23severe pre-eclampsia10.0LEP
24chronic infantile neurological cutaneous articular syndrome10.0TNFRSF1A, MEFV
25muckle-wells syndrome10.0MEFV, TNFRSF1A
26narcolepsy10.0LEP
27amyloidosis10.0MEFV, TNFRSF1A
28relapsing fever10.0TNFRSF1A, MEFV
29blau syndrome10.0MEFV, TNF
30multiple sclerosis10.0TNFRSF1A, TNF
31asthma10.0ADIPOQ, TNF
32synovitis10.0TNF, TNFRSF1A
33hepatitis b10.0ADIPOQ, TNFRSF1A
34acute myocardial infarction10.0RETN, MEFV
35vasculitis10.0MEFV, TNF
36ankylosing spondylitis10.0TNFRSF1A, TNF
37myocardial infarction10.0RETN, ADIPOQ
38behcet's disease10.0TNF, MEFV
39brucellosis10.0MEFV
40hypercholesterolemia10.0ADIPOQ, RETN
41choriocarcinoma10.0LEP
42stomach cancer10.0ADIPOQ, TNFRSF1A
43tumor necrosis factor receptor-associated periodic syndrome10.0TNFRSF1A, TNF, MEFV
44familial mediterranean fever10.0TNFRSF1A, TNF, MEFV
45galactosemia10.0LEP, TNF
46rheumatic disease10.0TNF, MEFV
47growth hormone deficiency10.0LEP, ADIPOQ
48graft versus host disease10.0TNFRSF1A, TNF
49hypertriglyceridemia10.0LEP, ADIPOQ
50hypogonadism10.0ADIPOQ, LEP

Graphical network of the top 20 diseases related to Idiopathic Recurrent Pericarditis:



Diseases related to idiopathic recurrent pericarditis

Clinical Features for Idiopathic Recurrent Pericarditis

Drugs & Therapeutics for Idiopathic Recurrent Pericarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Idiopathic Recurrent Pericarditis

Drug clinical trials:

Search ClinicalTrials for Idiopathic Recurrent Pericarditis

Search NIH Clinical Center for Idiopathic Recurrent Pericarditis

Search CenterWatch for Idiopathic Recurrent Pericarditis

Genetic Tests for Idiopathic Recurrent Pericarditis

Anatomical Context for Idiopathic Recurrent Pericarditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Idiopathic Recurrent Pericarditis:

33
Heart

Animal Models for Idiopathic Recurrent Pericarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Idiopathic Recurrent Pericarditis

Sources:
51PubMed
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Articles related to Idiopathic Recurrent Pericarditis:

(show all 24)
idTitleAuthorsYear
1
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
2
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. (23981280)
2013
3
A new case of idiopathic recurrent acute pericarditis due to R104Q mutation in TNFRSF1A successfully treated with anakinra: expanding the questions. (24295430)
2013
4
Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (23137677)
2013
5
Treatment of acute and recurrent idiopathic pericarditis. (23609551)
2013
6
Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. (21170606)
2013
7
Efficacy of an interleukin-1I^ receptor antagonist (anakinra) in idiopathic recurrent pericarditis. (23052671)
2013
8
Expanding spectrum of TNFRSF1A gene mutations among patients with idiopathic recurrent acute pericarditis. (23745996)
2013
9
Letter by Chhabra and Spodick regarding article, "Treatment of acute and recurrent idiopathic pericarditis". (24190942)
2013
10
Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (Anakinra). (23463131)
2013
11
Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. (22311714)
2012
12
Resolution of idiopathic recurrent pericarditis in a psoriatic arthritis patient treated with etanercept. (22155373)
2012
13
Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). (22704870)
2012
14
Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis. (20448129)
2010
15
Innate versus acquired immune response in the pathogenesis of recurrent idiopathic pericarditis. (19948252)
2010
16
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? (19116906)
2009
17
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
18
Pathogenetic mechanisms, new drugs, and old problems in idiopathic recurrent pericarditis: comment on the article by Picco et al. (19644862)
2009
19
Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. (20074469)
2009
20
Prognosis of idiopathic recurrent pericarditis as determined from previously published reports. (17826391)
2007
21
Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients. (16218464)
2005
22
Efficacy of high-dose intravenous immunoglobulins in two patients with idiopathic recurrent pericarditis refractory to previous immunosuppressive treatment. (12690925)
2003
23
IDIOPATHIC RECURRENT PERICARDITIS; A CASE REPORT. (14224691)
1965
24
Idiopathic recurrent pericarditis; comparison with the postcommissurotomy syndrome; considerations of etiology and treatment. (14361444)
1955

Genetic Variations for Idiopathic Recurrent Pericarditis

Expression for genes affiliated with Idiopathic Recurrent Pericarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Idiopathic Recurrent Pericarditis

Search GEO for disease gene expression data for Idiopathic Recurrent Pericarditis.

Pathways for genes affiliated with Idiopathic Recurrent Pericarditis

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 53R&D Systems, 30KEGG
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Pathways related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Signal transduction JNK pathway
Hide members
9.6TNF, TNFRSF1A
29.6TNFRSF1A, TNF
3
Hide members
9.6TNFRSF1A, TNF
4
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.6TNF, TNFRSF1A
59.6TNF, TNFRSF1A
69.6TNFRSF1A, TNF
79.6TNFRSF1A, TNF
8
Hide members
9.6TNF, TNFRSF1A
99.6TNFRSF1A, TNF
10
Hide members
9.6TNFRSF1A, TNF
119.1ADIPOQ, RETN
129.1RETN, ADIPOQ
138.2TNFRSF1A, TNF, LEP, ADIPOQ
14
Hide members
8.2TNFRSF1A, TNF, LEP, ADIPOQ
158.0RETN, NAMPT, LEP, ADIPOQ
16
Hide members
7.1ADIPOQ, LEP, NAMPT, RETN, TNF, TNFRSF1A

Compounds for genes affiliated with Idiopathic Recurrent Pericarditis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2412.4TNFRSF1A
2p0034510.4RETN
3glucose4510.3NAMPT
4fatty acid4510.3NAMPT
5norepinephrine45 11 2411.9TNFRSF1A, RETN
6bcma459.9TNFRSF1A, TNF
7blys459.9TNFRSF1A, TNF
8actinomycin459.8TNF, TNFRSF1A
9tab-1459.8TNFRSF1A, TNF
10clenbuterol45 1110.7TNF, LEP
112-arachidonoylglycerol45 2910.4LEP, ADIPOQ
12rimonabant45 29 1111.3LEP, ADIPOQ
13stavudine45 1110.3LEP, ADIPOQ
14sibutramine45 1110.3LEP, ADIPOQ
15infliximab45 50 1111.2ADIPOQ, TNF, TNFRSF1A
16topiramate45 11 2411.1LEP, ADIPOQ
17glimepiride45 50 1111.1RETN, ADIPOQ
18acipimox45 2910.1LEP, ADIPOQ
19simvastatin45 50 60 29 11 2414.1ADIPOQ, TNF, TNFRSF1A
20oxyntomodulin45 6010.0ADIPOQ, LEP
21atorvastatin45 50 29 11 2413.0TNF, RETN, ADIPOQ
22thiazolidinedione458.9ADIPOQ, LEP, RETN
23troglitazone45 29 60 1111.9ADIPOQ, LEP, TNF
2411beta-hydroxysteroid458.9RETN, LEP, ADIPOQ
25c-peptide458.9ADIPOQ, LEP, RETN
26dhea458.9RETN, LEP, ADIPOQ
27thyroxine45 249.8RETN, LEP, ADIPOQ
28actinomycin d458.6ADIPOQ, RETN, TNF, TNFRSF1A
29etanercept45 50 1110.6TNFRSF1A, TNF, LEP, ADIPOQ
30prostacyclin458.6TNFRSF1A, TNF, LEP, ADIPOQ
31methotrexate45 50 1110.6TNFRSF1A, TNF, LEP, ADIPOQ
32p002458.5TNFRSF1A, RETN, LEP, ADIPOQ
338-isoprostane458.5ADIPOQ, LEP, RETN, TNF
34fenofibrate45 50 1110.5TNF, RETN, LEP, ADIPOQ
35ly294002458.4ADIPOQ, LEP, RETN, TNF
36metformin45 50 1110.4ADIPOQ, LEP, NAMPT, RETN
37vitamin a45 11 2410.4ADIPOQ, LEP, RETN
38h2o2458.4ADIPOQ, LEP, TNF, TNFRSF1A
39endotoxin458.3TNFRSF1A, TNF, MEFV, RETN, ADIPOQ
40testosterone45 60 11 2411.3TNFRSF1A, RETN, LEP, ADIPOQ
41vegf458.2TNFRSF1A, TNF, RETN, LEP
42nash458.1ADIPOQ, LEP, RETN, TNF, TNFRSF1A
43creatinine458.0TNFRSF1A, RETN, NAMPT, LEP, ADIPOQ
44cholesterol45 29 11 2411.0ADIPOQ, LEP, NAMPT, RETN, TNFRSF1A
45pioglitazone45 50 29 1111.0TNF, RETN, NAMPT, LEP, ADIPOQ
46rosiglitazone45 50 29 11 2412.0ADIPOQ, LEP, NAMPT, RETN, TNF
47phosphatidylinositol458.0TNFRSF1A, RETN, NAMPT, LEP, ADIPOQ
48fibrinogen458.0TNF, RETN, NAMPT, LEP, ADIPOQ
49dexamethasone45 50 29 1110.6TNFRSF1A, TNF, RETN, NAMPT, LEP, ADIPOQ
50lipid457.5TNFRSF1A, TNF, RETN, NAMPT, LEP, ADIPOQ

GO Terms for genes affiliated with Idiopathic Recurrent Pericarditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8ADIPOQ, TNF, TNFRSF1A
2extracellular spaceGO:0056157.5ADIPOQ, LEP, RETN, TNF, TNFRSF1A
3extracellular regionGO:0055767.3TNFRSF1A, TNF, RETN, LEP, ADIPOQ

Biological processes related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.8TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNF, TNFRSF1A
3leukocyte tethering or rollingGO:0509019.6LEP, TNF
4positive regulation of cytokine productionGO:0018199.6TNF, LEP
5adipose tissue developmentGO:0606129.5NAMPT, LEP
6response to insulin stimulusGO:0328689.3LEP, RETN
7response to activityGO:0148239.3ADIPOQ, TNF
8negative regulation of fat cell differentiationGO:0455999.2TNF, ADIPOQ
9negative regulation of inflammatory responseGO:0507289.1ADIPOQ, MEFV, TNFRSF1A
10inflammatory responseGO:0069549.1MEFV, TNF, TNFRSF1A
11positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.0ADIPOQ, TNF, TNFRSF1A
12glucose metabolic processGO:0060068.8TNF, LEP, ADIPOQ
13circadian rhythmGO:0076238.7ADIPOQ, LEP
14response to hypoxiaGO:0016668.4ADIPOQ, LEP, TNF, TNFRSF1A

Molecular functions related to Idiopathic Recurrent Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7ADIPOQ, NAMPT, TNF
2hormone activityGO:0051798.2ADIPOQ, LEP, RETN

Products for genes affiliated with Idiopathic Recurrent Pericarditis

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Sources for Idiopathic Recurrent Pericarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet