MCID: IDP070
MIFTS: 41

Idiopathic Scoliosis malady

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

Aliases & Descriptions for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 14
Scoliosis Idiopathic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to adolescent idiopathic scoliosis and scoliosis, isolated 3. An important gene associated with Idiopathic Scoliosis is MTNR1B (Melatonin Receptor 1B), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Development Ligand-independent activation of ESR1 and ESR2. The drugs Morphine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 adolescent idiopathic scoliosis 12.4
2 scoliosis, isolated 3 11.6
3 gaze palsy, horizontal, with progressive scoliosis 10.9
4 scoliosis 10.8
5 deafness, autosomal recessive 21 10.2 ESR1 ESR2
6 her2-receptor negative breast cancer 10.2 ESR1 ESR2
7 osteogenesis imperfecta 10.1 ESR1 ESR2
8 ischemic bone disease 10.1 ESR1 IGF1 VDR
9 deafness, autosomal recessive 74 10.1 ESR1 ESR2 IGF1
10 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.1 ESR1 ESR2 LBX1
11 necrobiosis lipoidica 10.1 ESR1 ESR2 IGF1
12 edict syndrome 10.0 ESR1 IGF1 LEP
13 ulceroglandular tularemia 10.0 ESR1 ESR2
14 neuroschistosomiasis 10.0 COL1A2 ESR1 ESR2
15 bardet-biedl syndrome 10.0 ESR1 ESR2 IGF1
16 dysbaric osteonecrosis 10.0 ESR1 ESR2 IGF1 VDR
17 back pain 9.9
18 syringomyelia 9.9
19 geleophysic dysplasia 2 9.9 COL1A2 FBN1
20 spondylolisthesis 9.8
21 ganglioneuroma 9.8
22 afibrinogenemia 9.7 BNC2 CALM1 ESR1 IGF1 LBX1 MTNR1B
23 spondylolysis 9.7
24 osteoblastoma 9.7
25 chiari malformation 9.7
26 carnitine deficiency, systemic primary 9.6 COL1A2 ESR1 ESR2 IGF1 LEP VDR
27 respiratory failure 9.6
28 talipes equinovarus 9.6
29 arachnoiditis 9.6
30 conjugate gaze palsy 9.6
31 hyperostosis 9.6
32 cervicitis 9.6
33 marfan syndrome 9.6
34 motion sickness 9.6
35 insulin-like growth factor i 9.6
36 diastematomyelia 9.6
37 superior mesenteric artery syndrome 9.6
38 focal dystonia 9.6
39 dystonia 9.6
40 neuronitis 9.6
41 alexithymia 9.6
42 lung disease 9.6
43 thrombosis 9.6
44 spina bifida occulta 9.6
45 hemihypertrophy 9.6
46 sclerocornea 8.6 ACAN ADGRG6 BNC2 CALM1 CHD7 COL1A2
47 scapuloperoneal myopathy 8.0 ACAN ADGRG6 BNC2 CALM1 CHD7 COL1A2

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 VDR ADGRG6 CHD7 COL1A2 DSCAM ESR1
2 growth/size/body region MP:0005378 10.26 VDR ADGRG6 BNC2 CHD7 COL1A2 DSCAM
3 cellular MP:0005384 10.24 ADGRG6 CHD7 COL1A2 DSCAM ESR1 ESR2
4 cardiovascular system MP:0005385 10.21 ADGRG6 CHD7 COL1A2 ESR1 ESR2 FBN1
5 mortality/aging MP:0010768 10.18 ADGRG6 BNC2 CHD7 COL1A2 DSCAM ESR1
6 muscle MP:0005369 10.11 ADGRG6 CHD7 COL1A2 DSCAM ESR1 ESR2
7 limbs/digits/tail MP:0005371 10.09 ESR2 FBN1 IGF1 LBX1 LEP VDR
8 adipose tissue MP:0005375 10.08 CHD7 COL1A2 ESR1 ESR2 FBN1 IGF1
9 nervous system MP:0003631 10.02 ADGRG6 CHD7 DSCAM ESR1 ESR2 FBN1
10 integument MP:0010771 10 COL1A2 ESR1 ESR2 FBN1 IGF1 LEP
11 reproductive system MP:0005389 9.76 CHD7 DSCAM ESR1 ESR2 FBN1 IGF1
12 renal/urinary system MP:0005367 9.73 ESR2 FBN1 IGF1 LEP VDR ESR1
13 respiratory system MP:0005388 9.5 IGF1 LEP CHD7 DSCAM ESR1 ESR2
14 skeleton MP:0005390 9.36 ADGRG6 BNC2 CHD7 COL1A2 DSCAM ESR1

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
2
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Cyclobenzaprine Approved Phase 4 303-53-7 2895
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
10
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
11
Povidone-iodine Approved Phase 4 25655-41-8
12 Coagulants Phase 4,Phase 1,Phase 2
13 Hemostatics Phase 4,Phase 1,Phase 2
14 Thrombin Phase 4
15
Cobalt Phase 4 7440-48-4 104729
16 Micronutrients Phase 4,Phase 3
17 Trace Elements Phase 4,Phase 3
18 Analgesics Phase 4,Phase 3,Phase 2
19 Analgesics, Opioid Phase 4,Phase 2
20 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
21 Narcotics Phase 4,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
23 Anesthetics Phase 4,Phase 1,Phase 2
24 Anesthetics, Dissociative Phase 4,Phase 2
25 Anesthetics, General Phase 4,Phase 1,Phase 2
26 Anesthetics, Intravenous Phase 4,Phase 2
27 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
28 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
30 Anesthetics, Local Phase 4
31 Hypnotics and Sedatives Phase 4,Phase 2
32 Anti-Anxiety Agents Phase 4,Phase 3
33 Anticonvulsants Phase 4,Phase 3,Phase 2
34 calcium channel blockers Phase 4,Phase 3,Phase 2
35 Calcium, Dietary Phase 4,Phase 3,Phase 2
36 Psychotropic Drugs Phase 4,Phase 3
37 Tranquilizing Agents Phase 4,Phase 3
38 Acetaminophen, hydrocodone drug combination Phase 4
39 Ketorolac Tromethamine Phase 4
40 Anti-Infective Agents Phase 4
41 Anti-Infective Agents, Local Phase 4
42 Blood Substitutes Phase 4
43 cadexomer iodine Phase 4
44
Iodine Phase 4 7553-56-2 807
45 Pharmaceutical Solutions Phase 4
46 Plasma Substitutes Phase 4
47 Povidone Phase 4
48
Benzocaine Approved Phase 3,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
49
Calcium carbonate Approved Phase 3 471-34-1
50
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446

Interventional clinical trials:

(show top 50) (show all 105)
id Name Status NCT ID Phase
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
3 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109 Phase 4
4 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4
5 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4
6 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4
7 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4
8 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Recruiting NCT02651324 Phase 4
9 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4
10 Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery Not yet recruiting NCT02527512 Phase 4
11 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
12 Posterior Spinal Fusion With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
13 Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST) Completed NCT00448448 Phase 3
14 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
15 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
16 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3
17 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3
18 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Recruiting NCT02285621 Phase 3
19 The Use of Thoraco-lumbo-sacral Orthoses (TLSOs) in the Treatment of Adolescent Idiopathic Scoliosis (AIS) Terminated NCT01370057 Phase 3
20 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
21 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2
22 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2
23 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
24 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2
25 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2
26 Safety and Efficacy Study of Spinal Tethering Recruiting NCT02897453 Phase 2
27 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
28 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
29 Safety and Efficacy of Posture Correction Girdle for Adolescent With Early Scoliosis Enrolling by invitation NCT01776736 Phase 1
30 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
31 The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait Unknown status NCT00842218
32 Complementary Therapies in Spinal Fusion Patients Unknown status NCT02409615
33 Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342
34 Multi-Center Project: Spinal Abnormalities in Neurofibromatosis Type1 (NF1) Patients Unknown status NCT00667836
35 An Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis Completed NCT00886652
36 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
37 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
38 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534
39 The Comparison of Core Stabilization Exercise With Scientific Exercise Approach to Scoliosis in Idiopathic Scoliosis Completed NCT02978820
40 Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497
41 Ghrelin Resistance in Adolescents With Idiopathic Scoliosis Completed NCT02829476
42 Effectiveness of Exercises in Adolescent Idiopathic Scoliosis Completed NCT02552615
43 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
44 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
45 Feasibility Evaluation Study of the MID-C Device Completed NCT03071471
46 Feasibility Study of MID-C for AIS Completed NCT03071445
47 Adolescent Idiopathic Scoliosis and Mental Health Completed NCT00445393
48 Adolescent Idiopathic Scoliosis (AIS) Patient Positioning in EOS System® Completed NCT02269657
49 Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery Completed NCT02112409
50 Comprehensive Cohort Study of Bracing for Adolescent Idiopathic Scoliosis (AIS): A Feasibility Study Completed NCT00989495

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

39
Bone, Lung, Testes, Breast

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 297)
id Title Authors Year
1
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
2
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
3
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
4
Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis-a guide to reference values using serial imaging. ( 28065817 )
2017
5
Six-Month Follow-up of Supervised Spinal Stabilization Exercises for Low Back Pain in Adolescent Idiopathic Scoliosis. ( 27984472 )
2017
6
Predictors for Postoperative Shoulder Balance in Lenke 1 Adolescent Idiopathic Scoliosis: A Prospective Cohort Study. ( 28038696 )
2017
7
Is the Superior Articular Process a Reliable Landmark for Determining the Transverse Plane Angulation of Thoracic Pedicles in Patients With Adolescent Idiopathic Scoliosis? ( 28038694 )
2017
8
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
9
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
10
Accelerated Discharge Protocol for Posterior Spinal Fusion Patients With Adolescent Idiopathic Scoliosis Decreases Hospital Postoperative Charges 22. ( 28072636 )
2017
11
National Trends in the Surgical Management of Adolescent Idiopathic Scoliosis: Analysis of a National Estimate of 60,108 Children From the National Inpatient Sample Over a 13-Year Time Period in the United States. ( 28038695 )
2017
12
Diagnostic Accuracy of Combined Multimodality SSEP and TcMEP Intraoperative Monitoring in Patients with Idiopathic Scoliosis. ( 27172278 )
2016
13
Reversible Intraoperative Neurophysiologic Monitoring Alerts in Patients Undergoing Arthrodesis for Adolescent Idiopathic Scoliosis: What Are the Outcomes of Surgery? ( 27605692 )
2016
14
Morphometric analysis of iatrogenic breast asymmetry secondary to operative breast shape changes in thoracic adolescent idiopathic scoliosis. ( 27137998 )
2016
15
Spinal growth velocity versus height velocity in predicting curve progression in peri-pubertal girls with idiopathic scoliosis. ( 27562617 )
2016
16
Long-Term Effects of Untreated Adolescent Idiopathic Scoliosis: A Review of the Literature. ( 27994795 )
2016
17
Braces for Idiopathic Scoliosis in Adolescents. ( 27584672 )
2016
18
Association of spinal deformity and pelvic tilt with gait asymmetry in adolescent idiopathic scoliosis patients: Investigation of ground reaction force. ( 27214246 )
2016
19
How does implant distribution affect 3D correction and bone-screw forces in thoracic adolescent idiopathic scoliosis spinal instrumentation? ( 27639485 )
2016
20
Adolescent idiopathic scoliosis and back pain. ( 27648474 )
2016
21
Does Surgical Correction of Right Thoracic Scoliosis in Syringomyelia Produce Outcomes Similar to Those in Adolescent Idiopathic Scoliosis? ( 26888677 )
2016
22
Asymmetrical ossification in the epiphyseal ring of patients with adolescent idiopathic scoliosis: a retrospective review. ( 27143739 )
2016
23
Cervical sagittal alignment in adolescent idiopathic scoliosis patients (Lenke type 1-6). ( 28025024 )
2016
24
Comparison of pedicle screw fixation and hybrid instrumentation in adolescent idiopathic scoliosis. ( 27130393 )
2016
25
Validity and Reliability of Spine Rasterstereography in Patients with Adolescent Idiopathic Scoliosis. ( 27172281 )
2016
26
Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability. ( 26656046 )
2016
27
Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis. ( 27082501 )
2016
28
The outcome of modified version of the Cheneau brace in Adolescent Idiopathic Scoliosis (AIS) based on SRS and SOSORT criteria: a retrospective study. ( 27145218 )
2016
29
Metallosis Presenting as a Progressive Neurologic Deficit Four Years after a Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: A Case Report. ( 27172284 )
2016
30
A neglected point in surgical treatment of adolescent idiopathic scoliosis: Variations in the number of vertebrae. ( 27559975 )
2016
31
Efficacy of tranexamic acid in reducing allogeneic blood products in adolescent idiopathic scoliosis surgery. ( 27117696 )
2016
32
Pre-Operative Autologous Blood Donation Does Not Affect Pre-Incision Hematocrit in Adolescent Idiopathic Scoliosis Patients. A Retrospective Cohort of a Prospective Randomized Trial. ( 27652198 )
2016
33
A Comparison of Patient-Reported Outcome Measures Following Different Treatment Approaches for Adolescents with Severe Idiopathic Scoliosis: A Systematic Review. ( 27994796 )
2016
34
Correlations of VDR and VDBP genetic polymorphisms with susceptibility to adolescent idiopathic scoliosis and efficacy of brace treatment. ( 27856225 )
2016
35
Comparison of Functional Outcome and Quality of Life in Patients With Idiopathic Scoliosis Treated by Spinal Fusion. ( 27175629 )
2016
36
A validation study on the traditional Chinese version of Spinal Appearance Questionnaire for adolescent idiopathic scoliosis. ( 27167743 )
2016
37
Effect of physical therapy scoliosis specific exercises using breathing pattern on adolescent idiopathic scoliosis. ( 27942163 )
2016
38
One-step (standard) versus two-step surgical approach in adolescent idiopathic scoliosis posterior spinal fusion: Which is better? ( 27177634 )
2016
39
Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis. ( 27554350 )
2016
40
Incidence of cancer in adolescent idiopathic scoliosis patients treated 25 years previously. ( 27592106 )
2016
41
Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation. ( 26820155 )
2016
42
Genetic ACE I/D and ACTN3 R577X polymorphisms and adolescent idiopathic scoliosis. ( 27819725 )
2016
43
A retrospective study to reveal factors associated with postoperative shoulder imbalance in patients with adolescent idiopathic scoliosis with double thoracic curve. ( 27662445 )
2016
44
Accelerated Discharge Protocol for Posterior Spinal Fusion (PSF) Patients with Adolescent Idiopathic Scoliosis (AIS) Decreases Hospital Post-operative Charges 22. ( 27128392 )
2016
45
The Superiority of Intraoperative O-arm Navigation-assisted Surgery in Instrumenting Extremely Small Thoracic Pedicles of Adolescent Idiopathic Scoliosis: A Case-Control Study. ( 27149486 )
2016
46
Pulmonary function tests correlated with thoracic volumes in adolescent idiopathic scoliosis. ( 27208463 )
2016
47
Schroth Physiotherapeutic Scoliosis-Specific Exercises Added to the Standard of Care Lead to Better Cobb Angle Outcomes in Adolescents with Idiopathic Scoliosis - an Assessor and Statistician Blinded Randomized Controlled Trial. ( 28033399 )
2016
48
Posterior spinal instrumented fusion for idiopathic scoliosis in patients with multisystemic neurodegenerative disorder: a report of two cases. ( 27574278 )
2016
49
Radiation dose of digital radiography (DR) versus micro-dose x-ray (EOS) on patients with adolescent idiopathic scoliosis: 2016 SOSORT- IRSSD "John Sevastic Award" Winner in Imaging Research. ( 28035336 )
2016
50
The TGFB1 gene is associated with curve severity but not with the development of adolescent idiopathic scoliosis: a replication study in the Chinese population. ( 26758901 )
2016

Variations for Idiopathic Scoliosis

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

GO Terms for Idiopathic Scoliosis

Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 ACAN CALM1 COL1A2 DSCAM ESR2 FBN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 ADGRG6 ESR1 ESR2 IGF1 LEP MTNR1A
2 circadian rhythm GO:0007623 9.5 LEP MTNR1A MTNR1B
3 intracellular estrogen receptor signaling pathway GO:0030520 9.48 ESR1 ESR2
4 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.46 CALM1 CHD7
5 intestinal absorption GO:0050892 9.43 LEP VDR
6 steroid hormone mediated signaling pathway GO:0043401 9.43 ESR1 ESR2 VDR
7 proteoglycan biosynthetic process GO:0030166 9.4 ACAN IGF1
8 bone mineralization involved in bone maturation GO:0035630 9.16 IGF1 LEP
9 skeletal system development GO:0001501 9.1 ACAN CHD7 COL1A2 FBN1 IGF1 VDR
10 mammary gland branching involved in pregnancy GO:0060745 8.96 ESR1 VDR

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.63 FBN1 IGF1 LEP
2 extracellular matrix structural constituent GO:0005201 9.61 ACAN COL1A2 FBN1
3 steroid hormone receptor activity GO:0003707 9.58 ESR1 ESR2 VDR
4 nitric-oxide synthase regulator activity GO:0030235 9.37 CALM1 ESR1
5 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.33 ESR1 ESR2 VDR
6 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
7 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
8 melatonin receptor activity GO:0008502 8.96 MTNR1A MTNR1B
9 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Idiopathic Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....