MCID: IDP070
MIFTS: 42

Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 14
Scoliosis Idiopathic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to pectus excavatum and scoliosis. An important gene associated with Idiopathic Scoliosis is MTNR1B (Melatonin Receptor 1B), and among its related pathways/superpathways are Relaxin signaling pathway and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2. The drugs Thrombin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and brain, and related phenotypes are cardiovascular system and adipose tissue

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 pectus excavatum 28.9 ACAN ADGRG6 FBN1
2 scoliosis 27.3 ADGRG6 BNC2 CALM1 CHD7 COL1A2 FBN1
3 scoliosis, isolated 1 12.1
4 scoliosis, isolated 3 11.6
5 horizontal gaze palsy with progressive scoliosis 11.0
6 sarcoidosis 1 10.9
7 scoliosis, isolated 2 10.9
8 scoliosis, isolated 4 10.9
9 scoliosis, isolated 5 10.9
10 progesterone resistance 10.3 ESR1 ESR2
11 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2
12 progesterone-receptor positive breast cancer 10.3 ESR1 ESR2
13 gender identity disorder 10.3 ESR1 ESR2
14 estrogen excess 10.2 ESR1 ESR2
15 myopia 6 10.2 CHD7 FBN1
16 protrusio acetabuli 10.2 ESR1 FBN1
17 endometriosis of ovary 10.1 ESR1 ESR2
18 episodic pain syndrome, familial, 1 10.0
19 back pain 10.0
20 mass syndrome 10.0 FBN1 LEP
21 vaginitis 10.0 ESR1 ESR2
22 achondrogenesis, type ii 10.0 ACAN MATN1
23 syringomyelia 10.0
24 nontuberculous mycobacterial lung disease 9.9 FBN1 LEP
25 spondylolisthesis 9.9
26 ganglioneuroma 9.9
27 lobular neoplasia 9.9 ESR1 ESR2
28 lipoblastoma 9.9 COL1A2 LEP
29 exotropia 9.8 ACAN FBN1
30 mental retardation, x-linked, syndromic, snyder-robinson type 9.8
31 osteoblastoma 9.8
32 spondylolysis 9.8
33 cervicitis 9.8
34 chiari malformation 9.8
35 dental fluorosis 9.7 COL1A2 ESR1 ESR2
36 stiff skin syndrome 9.7 COL1A2 FBN1
37 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.6
38 marfan syndrome 9.6
39 motion sickness 9.6
40 scheuermann disease 9.6
41 neural tube defects 9.6
42 thrombophilia due to thrombin defect 9.6
43 diastematomyelia 9.6
44 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.6
45 hemihyperplasia, isolated 9.6
46 insulin-like growth factor i 9.6
47 orthostatic intolerance 9.6
48 body mass index quantitative trait locus 1 9.6
49 anxiety 9.6
50 focal dystonia 9.6

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 COL1A2 ESR1 ESR2 FBN1 LBX1 LEP
2 adipose tissue MP:0005375 9.8 CHD7 COL1A2 ESR1 ESR2 FBN1 LEP
3 limbs/digits/tail MP:0005371 9.7 CHD7 COL1A2 ESR1 ESR2 FBN1 LBX1
4 muscle MP:0005369 9.56 ESR1 ESR2 FBN1 LBX1 LEP ADGRG6
5 skeleton MP:0005390 9.28 ADGRG6 BNC2 CHD7 COL1A2 ESR1 ESR2

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
3
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Ibuprofen Approved Phase 4 15687-27-1 3672
7
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Cyclobenzaprine Approved Phase 4 303-53-7 2895
11
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
12 Coagulants Phase 4,Phase 1,Phase 2
13 Hemostatics Phase 4,Phase 1,Phase 2
14 Analgesics Phase 4,Phase 3,Phase 2
15 Analgesics, Opioid Phase 4,Phase 2
16 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
17 Narcotics Phase 4,Phase 2
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
19
Cobalt Phase 4 7440-48-4 104729
20 Micronutrients Phase 4,Phase 3
21 Trace Elements Phase 4,Phase 3
22 Anesthetics Phase 4,Phase 1,Phase 2
23 Anesthetics, Dissociative Phase 4,Phase 2
24 Anesthetics, General Phase 4,Phase 1,Phase 2
25 Anesthetics, Intravenous Phase 4,Phase 2
26 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
27 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
28 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
29 Anesthetics, Local Phase 4
30 Hypnotics and Sedatives Phase 4,Phase 2
31 Anti-Anxiety Agents Phase 4,Phase 3
32 Anticonvulsants Phase 4,Phase 3,Phase 2
33 calcium channel blockers Phase 4,Phase 3,Phase 2
34 Calcium, Dietary Phase 4,Phase 3,Phase 2
35 Psychotropic Drugs Phase 4,Phase 3
36 Tranquilizing Agents Phase 4,Phase 3
37 Acetaminophen, hydrocodone drug combination Phase 4
38
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
39
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
40
gamma-Aminobutyric acid Approved, Investigational Phase 3 56-12-2 119
41
Clevidipine Approved, Investigational Phase 2, Phase 3 167221-71-8
42
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 10883523 5280795 6221
43
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
45 Antacids Phase 3
46 Anti-Ulcer Agents Phase 3
47 Bone Density Conservation Agents Phase 3
48 Ergocalciferols Phase 3
49 Gastrointestinal Agents Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show top 50) (show all 112)

# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
3 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109 Phase 4
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
7 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
8 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
9 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
10 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
11 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Unknown status NCT02285621 Phase 3
12 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
13 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
14 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
15 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
16 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
17 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
18 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
19 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
20 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
21 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
22 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
23 Safety and Efficacy Study of Spinal Tethering Recruiting NCT02897453 Phase 2
24 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
25 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
26 Safety and Efficacy of Posture Correction Girdle for Adolescent With Early Scoliosis Enrolling by invitation NCT01776736 Phase 1
27 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
28 The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait Unknown status NCT00842218
29 Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
30 Multi-Center Project: Spinal Abnormalities in Neurofibromatosis Type1 (NF1) Patients Unknown status NCT00667836
31 Three-dimensional Effects of Bracing in Adolescent Idiopathic Scoliosis Completed NCT03298256
32 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
33 The Comparison of Core Stabilization Exercise With Scientific Exercise Approach to Scoliosis in Idiopathic Scoliosis Completed NCT02978820
34 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534
35 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
36 An Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis Completed NCT00886652
37 Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497
38 Ghrelin Resistance in Adolescents With Idiopathic Scoliosis Completed NCT02829476
39 Effectiveness of Exercises in Adolescent Idiopathic Scoliosis Completed NCT02552615
40 Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis Completed NCT01465295
41 Anesthetic Optimization in Scoliosis Surgery Completed NCT02481570
42 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
43 Feasibility Evaluation Study of the MID-C Device Completed NCT03071471
44 Feasibility Study of MID-C for AIS Completed NCT03071445
45 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
46 Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis Completed NCT02413788
47 Adolescent Idiopathic Scoliosis (AIS) Patient Positioning in EOS System® Completed NCT02269657
48 Adolescent Idiopathic Scoliosis and Mental Health Completed NCT00445393
49 Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery Completed NCT02112409
50 Function and Scoliosis Surgery Completed NCT02237248

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

38
Bone, Skeletal Muscle, Brain, Testes, Lung, Breast

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 350)
# Title Authors Year
1
Variation in Adolescent Idiopathic Scoliosis Surgery: Implications for Improving Healthcare Value. ( 29426688 )
2018
2
Bone Mineral Density After Spinal Fusion Surgery for Adolescent Idiopathic Scoliosis at a Minimum 20-Year Follow-up. ( 29413740 )
2018
3
Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389797 )
2018
4
Supplementary Addendum to "Radiation dose of digital radiography (DR) versus micro-dose x-ray (EOS) on patients with adolescent idiopathic scoliosis: 2016 SOSORT- IRSSD "John Sevastic Award" Winner in Imaging Research". ( 29435497 )
2018
5
Ethnic Variation in Satisfaction and Appearance Concerns in Adolescents With Idiopathic Scoliosis Undergoing Posterior Spinal Fusion With Instrumentation. ( 29413737 )
2018
6
Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review. ( 29434317 )
2018
7
Evidence-Based Thresholds for the Volume-Value Relationship in Adolescent Idiopathic Scoliosis: Outcomes and Economies of Scale. ( 29413738 )
2018
8
Who Needs a Pediatric Intensive Care Unit After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis? ( 29413735 )
2018
9
Additional Risk Factors for Adding-On After Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: Implication of Lowest Instrumented Vertebra Angle and Lumbosacral Takeoff. ( 29413739 )
2018
10
Vertebral Axial Asymmetry in Adolescent Idiopathic Scoliosis. ( 29413732 )
2018
11
2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. ( 29435499 )
2018
12
Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis. ( 29422531 )
2018
13
CORR InsightsAr: Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389798 )
2018
14
Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis-a guide to reference values using serial imaging. ( 28065817 )
2017
15
Accelerated Discharge Protocol for Posterior Spinal Fusion Patients With Adolescent Idiopathic Scoliosis Decreases Hospital Postoperative Charges 22. ( 28072636 )
2017
16
Anterior release may not be necessary for idiopathic scoliosis with large curve of more than 75A^ and flexibility less than 25. ( 28939170 )
2017
17
Analysing the change of sagittal balance in patients with Lenke 5 idiopathic scoliosis. ( 28889983 )
2017
18
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
19
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
20
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
21
Diffusion Tensor Imaging of Lumbar Vertebras in Female Adolescent Idiopathic Scoliosis: Initial Findings. ( 28937482 )
2017
22
Is the Superior Articular Process a Reliable Landmark for Determining the Transverse Plane Angulation of Thoracic Pedicles in Patients With Adolescent Idiopathic Scoliosis? ( 28038694 )
2017
23
Differential Rod Contouring is Essential for Improving Vertebral Rotation in Patients With Adolescent Idiopathic Scoliosis: Thoracic Curves Assessed With Intraoperative CT. ( 28953709 )
2017
24
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
25
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
26
The Role of Correction in the Conservative Treatment of Adolescent Idiopathic Scoliosis. ( 29399228 )
2017
27
Posture Alignment of Adolescent Idiopathic Scoliosis: Photogrammetry in Scoliosis School Screening. ( 28822476 )
2017
28
Imaging in the Diagnosis and Monitoring of Children with Idiopathic Scoliosis. ( 29399226 )
2017
29
Six-Month Follow-up of Supervised Spinal Stabilization Exercises for Low Back Pain in Adolescent Idiopathic Scoliosis. ( 27984472 )
2017
30
CELSR2 is a candidate susceptibility gene in idiopathic scoliosis. ( 29240829 )
2017
31
Impact of Scoliosis Severity on Functional Capacity in Patients with Adolescent Idiopathic Scoliosis. ( 28872419 )
2017
32
Scapular kinematics in adolescent idiopathic scoliosis: A three-dimensional motion analysis during multiplanar humeral elevation. ( 28823466 )
2017
33
Familial lumbar Scheuermann disease with idiopathic scoliosis in China: First case report. ( 28640085 )
2017
34
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. ( 28902104 )
2017
35
Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population. ( 28838314 )
2017
36
Progression of trunk imbalance in adolescent idiopathic scoliosis with a thoracolumbar/lumbar curve: is it predictable at the initial visit? ( 28885088 )
2017
37
Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis. ( 28334814 )
2017
38
Spinal Manipulative Therapy for Adolescent Idiopathic Scoliosis: A Systematic Review. ( 28822477 )
2017
39
An immediate effect of PNF specific mobilization on the angle of trunk rotation and the Trunk-Pelvis-Hip Angle range of motion in adolescent girls with double idiopathic scoliosis-a pilot study. ( 28905003 )
2017
40
Full fusion of proximal thoracic curve helps to prevent postoperative cervical tilt in Lenke type 2 adolescent idiopathic scoliosis patients with right-elevated shoulder. ( 28835232 )
2017
41
Thumb Ossification Composite Index (TOCI) for Predicting Peripubertal Skeletal Maturity and Peak Height Velocity in Idiopathic Scoliosis: A Validation Study of Premenarchal Girls with Adolescent Idiopathic Scoliosis Followed Longitudinally Until Skeletal Maturity. ( 28872525 )
2017
42
Distal adding-on phenomenon in adolescent idiopathic scoliosis patients with thoracolumbar vertebra fusion: A case-control study. ( 28930855 )
2017
43
Predictors for Postoperative Shoulder Balance in Lenke 1 Adolescent Idiopathic Scoliosis: A Prospective Cohort Study. ( 28038696 )
2017
44
A Modern Historical Perspective of Schroth Scoliosis Rehabilitation and Corrective Bracing Techniques for Idiopathic Scoliosis. ( 29399223 )
2017
45
Tracking low back pain in adolescent idiopathic scoliosis: a prospective cohort study protocol. ( 28878881 )
2017
46
The radiographic parameter risk factors of rapid curve progression in Lenke 5 and 6 adolescent idiopathic scoliosis: A retrospective study. ( 29384920 )
2017
47
Spine Growth Modulation in Early Adolescent Idiopathic Scoliosis: Two-Year Results of Prospective US FDA IDE Pilot Clinical Safety Study of Titanium Clip-Screw Implant. ( 28882349 )
2017
48
Quantitative evaluation of the relationship between COMP promoter methylation and the susceptibility and curve progression of adolescent idiopathic scoliosis. ( 28951969 )
2017
49
Whether Orthotic Management and Exercise are Equally Effective to the Patients With Adolescent Idiopathic Scoliosis in Mainland China?: A Randomized Controlled Trial Study. ( 28885287 )
2017
50
National Trends in the Surgical Management of Adolescent Idiopathic Scoliosis: Analysis of a National Estimate of 60,108 Children From the National Inpatient Sample Over a 13-Year Time Period in the United States. ( 28038695 )
2017

Variations for Idiopathic Scoliosis

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

GO Terms for Idiopathic Scoliosis

Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 ACAN COL1A2 FBN1 MATN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of nitric-oxide synthase activity GO:0050999 9.37 CALM1 LEP
2 circadian rhythm GO:0007623 9.33 LEP MTNR1A MTNR1B
3 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ESR1 ESR2
4 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.26 CALM1 CHD7
5 extracellular matrix organization GO:0030198 9.26 ACAN COL1A2 FBN1 MATN1
6 skeletal system development GO:0001501 8.92 ACAN CHD7 COL1A2 FBN1

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.37 ESR1 ESR2
2 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
3 melatonin receptor activity GO:0008502 9.26 MTNR1A MTNR1B
4 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
5 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
6 extracellular matrix structural constituent GO:0005201 8.92 ACAN COL1A2 FBN1 MATN1

Sources for Idiopathic Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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