MCID: IDP070
MIFTS: 39

Idiopathic Scoliosis

Categories: Bone diseases

Aliases & Classifications for Idiopathic Scoliosis

MalaCards integrated aliases for Idiopathic Scoliosis:

Name: Idiopathic Scoliosis 12 14
Scoliosis Idiopathic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0060250

Summaries for Idiopathic Scoliosis

Disease Ontology : 12 A scoliosis with no known cause.

MalaCards based summary : Idiopathic Scoliosis, also known as scoliosis idiopathic, is related to adolescent idiopathic scoliosis and scoliosis, isolated 3. An important gene associated with Idiopathic Scoliosis is MTNR1B (Melatonin Receptor 1B), and among its related pathways/superpathways are Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 and Plasma membrane estrogen receptor signaling. The drugs Thrombin and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skeletal muscle, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Idiopathic Scoliosis

Diseases related to Idiopathic Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 adolescent idiopathic scoliosis 12.4
2 scoliosis, isolated 3 11.5
3 horizontal gaze palsy with progressive scoliosis 10.9
4 scoliosis 10.8
5 sarcoidosis 1 10.8
6 deafness, autosomal dominant 8/12 10.5 ESR1 ESR2
7 ulceroglandular tularemia 10.5 ESR1 ESR2
8 her2-receptor positive breast cancer 10.5 ESR1 ESR2
9 osteogenesis imperfecta 10.5 ESR1 ESR2
10 acute thyroiditis 10.4 ESR1 ESR2
11 waardenburg syndrome, type 2e, with or without neurologic involvement 10.3 CHD7 FBN1
12 breast sarcoma 10.2 ESR1 ESR2
13 carbuncle 10.2 ESR1 ESR2
14 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.1 ESR1 ESR2 LBX1
15 weill-marchesani syndrome 2, dominant 10.1 FBN1 LEP
16 smed strudwick type 10.1 ACAN MATN1
17 back pain 10.0
18 syringomyelia 9.9
19 perinatal jaundice due to hepatocellular damage 9.9 ESR1 ESR2
20 lipoic acid biosynthesis defects 9.9 COL1A2 LEP
21 endometriosis of ovary 9.8 ACAN FBN1
22 spondylolisthesis 9.8
23 ganglioneuroma 9.8
24 chiari malformation 9.7
25 spondylolysis 9.7
26 cervicitis 9.7
27 osteoblastoma 9.7
28 not otherwise specified 3-mga-uria type 9.7 FBN1 LEP
29 neuroschistosomiasis 9.7 COL1A2 ESR1 ESR2
30 acromicric dysplasia 9.6 COL1A2 FBN1
31 thrombosis 9.6
32 spina bifida occulta 9.6
33 hemihypertrophy 9.6
34 respiratory failure 9.6
35 arachnoiditis 9.6
36 talipes equinovarus 9.6
37 conjugate gaze palsy 9.6
38 hyperostosis 9.6
39 marfan syndrome 9.6
40 insulin-like growth factor i 9.6
41 motion sickness 9.6
42 scheuermann disease 9.6
43 diastematomyelia 9.6
44 superior mesenteric artery syndrome 9.6
45 focal dystonia 9.6
46 dystonia 9.6
47 neuronitis 9.6
48 alexithymia 9.6
49 lung disease 9.6
50 chylomicron retention disease 9.2 COL1A2 ESR1 ESR2 LEP

Graphical network of the top 20 diseases related to Idiopathic Scoliosis:



Diseases related to Idiopathic Scoliosis

Symptoms & Phenotypes for Idiopathic Scoliosis

MGI Mouse Phenotypes related to Idiopathic Scoliosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ADGRG6 CHD7 COL1A2 ESR1 ESR2 FBN1
2 cardiovascular system MP:0005385 9.86 ADGRG6 CHD7 COL1A2 ESR1 ESR2 FBN1
3 adipose tissue MP:0005375 9.85 CHD7 COL1A2 ESR1 ESR2 FBN1 LEP
4 limbs/digits/tail MP:0005371 9.7 CHD7 COL1A2 ESR1 ESR2 FBN1 LBX1
5 muscle MP:0005369 9.56 ADGRG6 CHD7 COL1A2 ESR1 ESR2 FBN1
6 skeleton MP:0005390 9.28 LEP MATN1 ADGRG6 BNC2 CHD7 COL1A2

Drugs & Therapeutics for Idiopathic Scoliosis

Drugs for Idiopathic Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved Phase 4
2
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
3
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Ibuprofen Approved Phase 4 15687-27-1 3672
7
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Cyclobenzaprine Approved Phase 4 303-53-7 2895
11
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
12 Coagulants Phase 4,Phase 1,Phase 2
13 Hemostatics Phase 4,Phase 1,Phase 2
14
Cobalt Phase 4 7440-48-4 104729
15 Micronutrients Phase 4,Phase 3
16 Trace Elements Phase 4,Phase 3
17 Analgesics Phase 4,Phase 3,Phase 2
18 Analgesics, Opioid Phase 4,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Narcotics Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
22 Anesthetics Phase 4,Phase 1,Phase 2
23 Anesthetics, Dissociative Phase 4,Phase 2
24 Anesthetics, General Phase 4,Phase 1,Phase 2
25 Anesthetics, Intravenous Phase 4,Phase 2
26 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
27 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
28 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
29 Anesthetics, Local Phase 4
30 Hypnotics and Sedatives Phase 4,Phase 2
31 Anti-Anxiety Agents Phase 4,Phase 3
32 Anticonvulsants Phase 4,Phase 3,Phase 2
33 calcium channel blockers Phase 4,Phase 3,Phase 2
34 Calcium, Dietary Phase 4,Phase 3,Phase 2
35 Psychotropic Drugs Phase 4,Phase 3
36 Tranquilizing Agents Phase 4,Phase 3
37 Acetaminophen, hydrocodone drug combination Phase 4
38
Calcium Carbonate Approved Phase 3 471-34-1
39
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
40
Clevidipine Approved Phase 2, Phase 3 167221-71-8
41
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 6221 10883523 5280795
42
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
44
gamma-Aminobutyric acid Investigational Phase 3 56-12-2 119
45 Antacids Phase 3
46 Anti-Ulcer Agents Phase 3
47 Bone Density Conservation Agents Phase 3
48 Ergocalciferols Phase 3
49 Gastrointestinal Agents Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show top 50) (show all 111)

id Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
3 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109 Phase 4
4 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
5 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
6 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
7 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
8 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
9 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
10 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
11 Posterior Spinal Fusion With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
12 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
13 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
14 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
15 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
16 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Recruiting NCT02285621 Phase 3
17 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
18 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
19 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
20 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
21 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
22 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
23 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
24 Safety and Efficacy Study of Spinal Tethering Recruiting NCT02897453 Phase 2
25 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1
26 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
27 Safety and Efficacy of Posture Correction Girdle for Adolescent With Early Scoliosis Enrolling by invitation NCT01776736 Phase 1
28 Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis Unknown status NCT02227537
29 The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait Unknown status NCT00842218
30 Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery Unknown status NCT02084342 tranexamic acid and sodium chloride injection;normal saline;desmopressin acetate injection
31 Multi-Center Project: Spinal Abnormalities in Neurofibromatosis Type1 (NF1) Patients Unknown status NCT00667836
32 Three-dimensional Effects of Bracing in Adolescent Idiopathic Scoliosis Completed NCT03298256
33 An Aerobic Exercising Program on Respiratory Muscle Strength in Patients With Adolescent Idiopathic Scoliosis Completed NCT00886652
34 Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation Completed NCT01109082
35 Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis Completed NCT02412137 Early Phase 1
36 Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA) Completed NCT02302534
37 The Comparison of Core Stabilization Exercise With Scientific Exercise Approach to Scoliosis in Idiopathic Scoliosis Completed NCT02978820
38 Spinal Stabilization Exercises for Low Back Pain in Adolescents With Idiopathic Scoliosis Completed NCT01550497
39 Ghrelin Resistance in Adolescents With Idiopathic Scoliosis Completed NCT02829476
40 Effectiveness of Exercises in Adolescent Idiopathic Scoliosis Completed NCT02552615
41 Short-term Effects of the Simultaneous Use of Two Physiotherapeutic Methods in the Treatment of Adolescent Idiopathic Scoliosis - Pilot Study Completed NCT01250860
42 A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace Completed NCT01336114
43 Anesthetic Optimization in Scoliosis Surgery Completed NCT02481570
44 Feasibility Evaluation Study of the MID-C Device Completed NCT03071471
45 Feasibility Study of MID-C for AIS Completed NCT03071445
46 Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis Completed NCT02413788
47 Adolescent Idiopathic Scoliosis and Mental Health Completed NCT00445393
48 Adolescent Idiopathic Scoliosis (AIS) Patient Positioning in EOS System® Completed NCT02269657
49 Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery Completed NCT02112409
50 Comprehensive Cohort Study of Bracing for Adolescent Idiopathic Scoliosis (AIS): A Feasibility Study Completed NCT00989495

Search NIH Clinical Center for Idiopathic Scoliosis

Genetic Tests for Idiopathic Scoliosis

Anatomical Context for Idiopathic Scoliosis

MalaCards organs/tissues related to Idiopathic Scoliosis:

39
Bone, Brain, Skeletal Muscle, Lung, Testes, Breast

Publications for Idiopathic Scoliosis

Articles related to Idiopathic Scoliosis:

(show top 50) (show all 325)
id Title Authors Year
1
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
2
Analysing the change of sagittal balance in patients with Lenke 5 idiopathic scoliosis. ( 28889983 )
2017
3
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
4
Pulmonary function and thoracic deformities in adolescent idiopathic scoliosis 27 years or longer after spinal fusion with Harrington instrument. ( 28887065 )
2017
5
Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis-a guide to reference values using serial imaging. ( 28065817 )
2017
6
Impact of Scoliosis Severity on Functional Capacity in Patients with Adolescent Idiopathic Scoliosis. ( 28872419 )
2017
7
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
8
An immediate effect of PNF specific mobilization on the angle of trunk rotation and the Trunk-Pelvis-Hip Angle range of motion in adolescent girls with double idiopathic scoliosis-a pilot study. ( 28905003 )
2017
9
Full fusion of proximal thoracic curve helps to prevent postoperative cervical tilt in Lenke type 2 adolescent idiopathic scoliosis patients with right-elevated shoulder. ( 28835232 )
2017
10
Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis. ( 28334814 )
2017
11
Distal adding-on phenomenon in adolescent idiopathic scoliosis patients with thoracolumbar vertebra fusion: A case-control study. ( 28930855 )
2017
12
Diffusion Tensor Imaging of Lumbar Vertebras in Female Adolescent Idiopathic Scoliosis: Initial Findings. ( 28937482 )
2017
13
Can surgery for adolescent idiopathic scoliosis of less than 50 degrees of main thoracic curve achieve good results? ( 28943143 )
2017
14
Thumb Ossification Composite Index (TOCI) for Predicting Peripubertal Skeletal Maturity and Peak Height Velocity in Idiopathic Scoliosis: A Validation Study of Premenarchal Girls with Adolescent Idiopathic Scoliosis Followed Longitudinally Until Skeletal Maturity. ( 28872525 )
2017
15
Familial lumbar Scheuermann disease with idiopathic scoliosis in China: First case report. ( 28640085 )
2017
16
Genetic variant of BNC2 gene is functionally associated with adolescent idiopathic scoliosis in Chinese population. ( 28342042 )
2017
17
Spine Growth Modulation in Early Adolescent Idiopathic Scoliosis: Two-Year Results of Prospective US FDA IDE Pilot Clinical Safety Study of Titanium Clip-Screw Implant. ( 28882349 )
2017
18
Is the Superior Articular Process a Reliable Landmark for Determining the Transverse Plane Angulation of Thoracic Pedicles in Patients With Adolescent Idiopathic Scoliosis? ( 28038694 )
2017
19
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
20
Differential Rod Contouring is Essential for Improving Vertebral Rotation in Patients With Adolescent Idiopathic Scoliosis: Thoracic Curves Assessed With Intraoperative CT. ( 28953709 )
2017
21
Progression of trunk imbalance in adolescent idiopathic scoliosis with a thoracolumbar/lumbar curve: is it predictable at the initial visit? ( 28885088 )
2017
22
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
23
Predictors for Postoperative Shoulder Balance in Lenke 1 Adolescent Idiopathic Scoliosis: A Prospective Cohort Study. ( 28038696 )
2017
24
Accelerated Discharge Protocol for Posterior Spinal Fusion Patients With Adolescent Idiopathic Scoliosis Decreases Hospital Postoperative Charges 22. ( 28072636 )
2017
25
Scapular kinematics in adolescent idiopathic scoliosis: A three-dimensional motion analysis during multiplanar humeral elevation. ( 28823466 )
2017
26
Anterior release may not be necessary for idiopathic scoliosis with large curve of more than 75A^ and flexibility less than 25. ( 28939170 )
2017
27
Six-Month Follow-up of Supervised Spinal Stabilization Exercises for Low Back Pain in Adolescent Idiopathic Scoliosis. ( 27984472 )
2017
28
Whether Orthotic Management and Exercise are Equally Effective to the Patients With Adolescent Idiopathic Scoliosis in Mainland China?: A Randomized Controlled Trial Study. ( 28885287 )
2017
29
Posture Alignment of Adolescent Idiopathic Scoliosis: Photogrammetry in Scoliosis School Screening. ( 28822476 )
2017
30
Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population. ( 28838314 )
2017
31
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. ( 28902104 )
2017
32
H-reflex changes in adolescents with idiopathic scoliosis: a randomized clinical trial. ( 28932008 )
2017
33
A comparison of ultrasonography measurement on the abdominal muscles thickness between adolescent idiopathic scoliosis and healthy subjects. ( 28826167 )
2017
34
Tracking low back pain in adolescent idiopathic scoliosis: a prospective cohort study protocol. ( 28878881 )
2017
35
Prevalence, Risk Factors and Characteristics of the 'Adding-on' Phenomenon in Idiopathic Scoliosis after Correction Surgery: A Systematic Review and Meta-Analysis. ( 28937532 )
2017
36
Spinal Manipulative Therapy for Adolescent Idiopathic Scoliosis: A Systematic Review. ( 28822477 )
2017
37
Quantitative evaluation of the relationship between COMP promoter methylation and the susceptibility and curve progression of adolescent idiopathic scoliosis. ( 28951969 )
2017
38
National Trends in the Surgical Management of Adolescent Idiopathic Scoliosis: Analysis of a National Estimate of 60,108 Children From the National Inpatient Sample Over a 13-Year Time Period in the United States. ( 28038695 )
2017
39
Incidence of cancer in adolescent idiopathic scoliosis patients treated 25 years previously. ( 27592106 )
2016
40
Metallosis Presenting as a Progressive Neurologic Deficit Four Years after a Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: A Case Report. ( 27172284 )
2016
41
Trunk appearance perception scale for physicians (TAPS-Phy) - a valid and reliable tool to rate trunk deformity in idiopathic scoliosis. ( 27579446 )
2016
42
Psychometric evaluation of the Scoliosis Research Society-22 Revised questionnaire among adolescents with idiopathic scoliosis. ( 27182754 )
2016
43
Comparison of pedicle screw fixation and hybrid instrumentation in adolescent idiopathic scoliosis. ( 27130393 )
2016
44
Erratum: Adolescent Idiopathic Scoliosis and Pregnancy: An Unsolved Paradigm. ( 27556004 )
2016
45
Evaluation of IRX Genes and Conserved Non-coding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis. ( 27172222 )
2016
46
Association Between IL-6 and MMP3 Common Genetic Polymorphisms and Idiopathic Scoliosis in Bulgarian Patients: A Case-control Study. ( 26656061 )
2016
47
Effects of Multilevel Facetectomy and Screw Density on Postoperative Changes in Spinal Rod Contour in Thoracic Adolescent Idiopathic Scoliosis Surgery. ( 27564683 )
2016
48
Efficacy of tranexamic acid in reducing allogeneic blood products in adolescent idiopathic scoliosis surgery. ( 27117696 )
2016
49
The effectiveness of core stabilization exercise in adolescent idiopathic scoliosis: A randomized controlled trial. ( 27625122 )
2016
50
Correlations of VDR and VDBP genetic polymorphisms with susceptibility to adolescent idiopathic scoliosis and efficacy of brace treatment. ( 27856225 )
2016

Variations for Idiopathic Scoliosis

Expression for Idiopathic Scoliosis

Search GEO for disease gene expression data for Idiopathic Scoliosis.

Pathways for Idiopathic Scoliosis

Pathways related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.7 ESR1 ESR2
2 10.57 ESR1 ESR2
3 10.32 ESR1 ESR2
4 9.23 ESR1 ESR2

GO Terms for Idiopathic Scoliosis

Cellular components related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 ACAN COL1A2 FBN1 MATN1

Biological processes related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.33 LEP MTNR1A MTNR1B
2 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ESR1 ESR2
3 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.26 CALM1 CHD7
4 extracellular matrix organization GO:0030198 9.26 ACAN COL1A2 FBN1 MATN1
5 skeletal system development GO:0001501 8.92 ACAN CHD7 COL1A2 FBN1

Molecular functions related to Idiopathic Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.37 ESR1 ESR2
2 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
3 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
4 melatonin receptor activity GO:0008502 9.16 MTNR1A MTNR1B
5 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
6 extracellular matrix structural constituent GO:0005201 8.92 ACAN COL1A2 FBN1 MATN1

Sources for Idiopathic Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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