Aliases & Classifications for Ileitis

Aliases & Descriptions for Ileitis:

Name: Ileitis 12 52 42 14 69
Crohn's Ileitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060189
ICD10 33 K52.9
MeSH 42 D007079
NCIt 47 C84782
SNOMED-CT 64 52457000
UMLS 69 C0020877

Summaries for Ileitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in ileum, has symptom diarrhea, has symptom abdominal pain, often in the right lower quadrant, has symptom weight loss.

MalaCards based summary : Ileitis, also known as crohn's ileitis, is related to tuberculosis and collagenous colitis, and has symptoms including diarrhea, abdominal pain and weight loss. An important gene associated with Ileitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Clarithromycin and Clofazimine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, t cells and b cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 71 Ileitis is an inflammation of the ileum, a portion of the small intestine. Crohn\'s ileitis is a type of... more...

Related Diseases for Ileitis

Diseases related to Ileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.6 IL17A IL6 TNF
2 collagenous colitis 28.8 CCR3 IL17A IL6 MPO NOD2 TLR4
3 crohn's disease 11.4
4 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
5 dyslexia 5 10.3 IL6 TNF
6 dermatosis papulosa nigra 10.3 NOD2 TNF
7 aortic atherosclerosis 10.2 IL6 TNF
8 spondylometaphyseal dysplasia east-african type 10.2 TLR4 TNF
9 degenerative disc disease 10.2 IL6 TNF
10 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.2 MPO TNF
11 nguyen syndrome 10.2 IL17A TLR2
12 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL6 TLR4 TNF
13 mikulicz disease 10.2 IL6 TLR4 TNF
14 spotted fever 10.2 TLR2 TLR4 TNF
15 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL6 TLR4 TNF
16 aseptic meningitis 10.2 TLR2 TLR4 TNF
17 autosomal recessive type iv ehlers-danlos syndrome 10.2 IL6 TLR4 TNF
18 low compliance bladder 10.2 TLR4 TNF
19 parasitic ichthyosporea infectious disease 10.2 TLR2 TLR4 TNF
20 pseudoainhum 10.2 TLR2 TLR4
21 rickettsialpox 10.2 TLR2 TLR4 TNF
22 immunoglobulin g deficiency 10.2 IL6 TLR4 TNF
23 myiasis 10.2 IL6 TLR4 TNF
24 blepharochalasis 10.2 IL6 TLR4 TNF
25 abnormal retinal correspondence 10.2 TLR2 TLR4 TNF
26 ovarian cystic teratoma 10.2 TLR2 TLR4 TNF
27 choroiditis 10.2 IL6 TLR4 TNF
28 female reproductive system disease 10.2 IL17A NOD2 TNF
29 infancy electroclinical syndrome 10.2 IL6 TLR4 TNF
30 leptospirosis 10.2 IL17A NOD2 TNF
31 premature menopause 10.2 IL6 NOD2 TLR2
32 coronary arterial fistulas 10.2 NOD2 TLR4
33 leukoplakia of vagina 10.2 IL6 TLR2 TNF
34 unilateral hypoactive labyrinth 10.2 TLR2 TLR4 TNF
35 polyarteritis nodosa 10.2 IL17A TLR2 TLR4
36 dengue hemorrhagic fever 10.2 TLR2 TLR4 TNF
37 autoimmune disease of central nervous system 10.2 IL6 TLR2 TNF
38 neovascular glaucoma 10.2 IL6 TLR4 TNF
39 trichomalacia 10.2 IL17A IL6 TNF
40 liver inflammatory pseudotumor 10.2 TLR2 TLR4 TNF
41 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
42 gastric dilatation 10.2 IL17A IL6 TNF
43 pulmonary tuberculosis 10.2 IL6 TLR4 TNF
44 atrophy of prostate 10.2 IL6 TLR2 TNF
45 choanal atresia, bilateral 10.2 IL17A IL6 TNF
46 keratoconus 10.2 IL17A IL6 TNF
47 celiac disease 10.2 IL17A NOD2 TNF
48 measles 10.2 FABP2 IL6 TNF
49 orbital osteomyelitis 10.2 IL17A IL6 TNF
50 reproductive system disease 10.2 IL17A IL6 TLR2

Graphical network of the top 20 diseases related to Ileitis:



Diseases related to Ileitis

Symptoms & Phenotypes for Ileitis

Symptoms:

12
  • diarrhea
  • abdominal pain
  • weight loss

MGI Mouse Phenotypes related to Ileitis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CCR3 FABP2 IL17A IL6 MPO NOD2
2 hematopoietic system MP:0005397 10.2 CCR3 IL17A IL6 MPO NOD2 STAT3
3 growth/size/body region MP:0005378 10.18 TLR4 TLR5 TNF XPNPEP1 FABP2 IL17A
4 immune system MP:0005387 10.14 XPNPEP1 CCR3 IL17A IL6 MPO NOD2
5 digestive/alimentary MP:0005381 10.1 IL17A IL6 NOD2 STAT3 TLR2 TLR4
6 adipose tissue MP:0005375 10.05 TNF FABP2 IL6 STAT3 TLR2 TLR4
7 mortality/aging MP:0010768 10.02 IL17A IL6 MPO NOD2 STAT3 TLR2
8 liver/biliary system MP:0005370 9.91 FABP2 IL6 STAT3 TLR2 TLR4 TLR5
9 muscle MP:0005369 9.73 IL6 MPO STAT3 TLR2 TLR4 TNF
10 renal/urinary system MP:0005367 9.7 FABP2 IL17A IL6 STAT3 TLR2 TLR4
11 respiratory system MP:0005388 9.56 CCR3 IL17A IL6 STAT3 TLR2 TLR4
12 skeleton MP:0005390 9.17 IL17A IL6 NOD2 STAT3 TLR2 TLR4

Drugs & Therapeutics for Ileitis

Drugs for Ileitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4 81103-11-9 84029
2
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
3
Rifabutin Approved Phase 4 72559-06-9 6323490
4
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
5
Vedolizumab Approved Phase 4 943609-66-3
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 3
10 Antitubercular Agents Phase 4,Phase 2
11 Cytochrome P-450 CYP3A Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
14 Gastrointestinal Agents Phase 4,Phase 3
15 Topoisomerase Inhibitors Phase 4
16
Adalimumab Approved Phase 3 331731-18-1 16219006
17 6-Mercaptopurine Phase 3
18 Antimetabolites Phase 3
19 Antimetabolites, Antineoplastic Phase 3
20 Antirheumatic Agents Phase 3
21 Immunosuppressive Agents Phase 3
22 Nucleic Acid Synthesis Inhibitors Phase 3
23
Alicaforsen Phase 3 185229-68-9 16197724
24
Menthol Approved Phase 2 2216-51-5 16666
25
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
26 Antibodies Phase 2,Phase 1
27 Antibodies, Monoclonal Phase 2,Phase 1
28 Immunoglobulins Phase 2,Phase 1
29
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
30 Defensins
31 Cortisol succinate
32 Hydrocortisone 17-butyrate 21-propionate
33 Hydrocortisone acetate
34 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4
3 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3
4 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
5 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3
6 Randomized Study of Topical Alicaforsen Enema in Antibiotic Refractory Pouchitis Recruiting NCT02525523 Phase 3
7 An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease Completed NCT01090817 Phase 2
8 Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease. Completed NCT02031276 Phase 2
9 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
10 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2
11 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Recruiting NCT02782325 Phase 1, Phase 2
12 FMT in Ulcerative Colitis-Associated Pouchitis Recruiting NCT02049502 Phase 2
13 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2
14 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2
15 Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs Completed NCT01387594 Phase 1
16 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1
17 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
18 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
19 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Recruiting NCT02828410
20 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419
21 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1
22 Comparing the Quality of Life of Terminal Ileitis Patients With Crohn's Disease Treated With Anti-TNF or Surgical Resection Not yet recruiting NCT02872506

Search NIH Clinical Center for Ileitis

Cochrane evidence based reviews: ileitis

Genetic Tests for Ileitis

Anatomical Context for Ileitis

MalaCards organs/tissues related to Ileitis:

39
Small Intestine, T Cells, B Cells, Colon, Breast, Appendix, Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Ileitis:

18
Ileum

Publications for Ileitis

Articles related to Ileitis:

(show top 50) (show all 123)
id Title Authors Year
1
Defective ATG16L1-mediated removal of IRE1I+ drives Crohn's disease-like ileitis. ( 28082357 )
2017
2
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A CAPENTRY Study. ( 27889847 )
2017
3
An unexpected cause of terminal ileitis. ( 27729214 )
2017
4
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
5
Sequential Crohn's Ileitis, Ileosigmoidal Fistula, Segmental Sigmoid Polyposis, and Sigmoid Stricture: The Natural History. ( 27466165 )
2016
6
Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. ( 27581119 )
2016
7
Terminal Ileitis as a Feature of Henoch-SchAPnlein Purpura Masquerading as Crohn Disease in Adults. ( 26906301 )
2016
8
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium. ( 27930931 )
2016
9
Relapsing Olmesartan-Associated Ileitis. ( 27539736 )
2016
10
IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis. ( 26908008 )
2016
11
Clostridium difficile ileitis in a patient, after total colectomy. ( 26903365 )
2016
12
Emergency laparoscopic ileo-colic resection and primary intracorporeal anastomosis for Crohn's acute ileitis with free perforation and faecal peritonitis: first ever reported laparoscopic treatment. ( 26759755 )
2016
13
Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. ( 26881175 )
2016
14
Visceral Hypersensitivity Is Provoked by 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ileitis in Rats. ( 27499743 )
2016
15
A novel model for studying ileitis-induced visceral hypersensitivity in goats. ( 27716368 )
2016
16
Dietary Creatine as a Possible Novel Treatment for Crohn's Ileitis. ( 28008406 )
2016
17
Capsule Endoscopy for Ileitis with Potential Involvement of Other Sections of the Small Bowel. ( 26880904 )
2016
18
Visceral pain triggered by traction on the ileocecal ligament with ileitis. ( 27757049 )
2016
19
Isolated ileitis associated with primary sclerosing cholangitis in three patients with Crohn's disease. ( 26806276 )
2016
20
Multiples ileal adenomas in Crohn's disease: Sporadic or ileitis associated dysplasia? ( 28040346 )
2016
21
Tuberculosis terminal ileitis: A forgotten entity mimicking Crohn's disease. ( 27672643 )
2016
22
Prospective Evaluation of Terminal Ileitis in a Surveillance Population of Patients with Ulcerative Colitis. ( 27580386 )
2016
23
Facing Terminal Ileitis: Going Beyond Crohn's Disease. ( 27785317 )
2016
24
Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. ( 27848951 )
2016
25
Frequency, natural course and clinical significance of symptomatic terminal ileitis. ( 26670338 )
2016
26
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 27591764 )
2016
27
Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis. ( 25637591 )
2015
28
Segmental sigmoid polyposis as a colonoscopic indicator of an ileosigmoid fistula in Crohn's ileitis. ( 25634034 )
2015
29
Severe ileitis associated with capecitabine: Two case reports and review of the literature. ( 26807255 )
2015
30
Editorial: CCR7 is required for leukocyte egression in an experimental model of Crohn's disease-like ileitis. ( 26031490 )
2015
31
Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis. ( 26053862 )
2015
32
Dysregulated intrahepatic CD4(+) T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. ( 26213712 )
2015
33
First molecular identification of Entamoeba polecki in a piglet in Japan and implications for aggravation of ileitis by coinfection with Lawsonia intracellularis. ( 25963884 )
2015
34
Terminal ileitis induced by Henoch-Schonlein purpura that presented as acute appendicitis: a case report. ( 25654396 )
2015
35
High Spatiotemporal Resolution Dynamic Contrast-Enhanced MR Enterography in Crohn Disease Terminal Ileitis Using Continuous Golden-Angle Radial Sampling, Compressed Sensing, and Parallel Imaging. ( 26001254 )
2015
36
Quantitative Assessment of Inflammation in a Porcine Acute Terminal Ileitis Model: US with a Molecularly Targeted Contrast Agent. ( 25965901 )
2015
37
Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis. ( 25885696 )
2015
38
Clostridium Difficile Ileitis in Pediatric Inflammatory Bowel Disease: a Case Report and Literature Review. ( 25611030 )
2015
39
Maternal High-fat Diet Accelerates Development of Crohn's Disease-like Ileitis in TNFI9ARE/WT Offspring. ( 26284294 )
2015
40
P219. The relevance of ileitis as diagnosed by capsule endoscopy: A comparison with double balloon enteroscopy. ( 25717687 )
2015
41
DOP073. Regularities of expression of membrane-associated and cytoplasmic pattern recognition receptors, as well as transcriptional regulation of T-helper cells by lymphocytes in experimental ileitis and conduct of the simvastatin and aril-1. ( 25718287 )
2015
42
P118. Incidence and Severity of Pre-pouch Ileitis: A Distinct Disease Entity or a Manifestation of Refractory. ( 25717577 )
2015
43
Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis. ( 26218140 )
2015
44
Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice. ( 26495132 )
2015
45
Toll-like receptor (TLR) 2 agonists ameliorate indomethacin-induced murine ileitis by suppressing the TLR4 signaling. ( 25867219 )
2015
46
Experimental ileitis alters prostaglandin biosynthesis in mesenteric lymphatic and blood vessels. ( 25526689 )
2015
47
Host and microbiota interactions are critical for development of murine Crohn's-like ileitis. ( 26487367 )
2015
48
Proximal ileitis secondary to anisakiasis. ( 26743576 )
2015
49
SAMP1/YitFc Mice Develop Ileitis via Loss of CCL21 and Defects in Dendritic Cell Migration. ( 25620669 )
2015
50
Fecal Microbial Transplant After Ileocolic Resection Reduces Ileitis but Restores Colitis in IL-10-/- Mice. ( 26070001 )
2015

Variations for Ileitis

Expression for Ileitis

Search GEO for disease gene expression data for Ileitis.

Pathways for Ileitis

Pathways related to Ileitis according to GeneCards Suite gene sharing:

(show all 49)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 IL17A IL6 MPO NOD2 STAT3 TLR2
2
Show member pathways
13.28 CCR3 IL17A IL6 STAT3 TLR2 TLR4
3
Show member pathways
12.93 IL6 NOD2 TLR2 TLR4 TLR5 TNF
4
Show member pathways
12.83 IL6 STAT3 TLR2 TLR4 TLR5 TNF
5
Show member pathways
12.74 IL6 STAT3 TLR2 TLR4 TNF
6
Show member pathways
12.64 IL6 TLR2 TLR4 TLR5 TNF
7
Show member pathways
12.54 IL17A IL6 MPO STAT3 TNF
8 12.48 IL17A MPO STAT3 TLR2 TNF
9 12.26 STAT3 TLR2 TLR4 TNF
10
Show member pathways
12.22 STAT3 TLR2 TLR4 TNF
11
Show member pathways
12.21 IL17A IL6 STAT3 TLR2 TLR5 TNF
12
Show member pathways
12.2 IL6 TLR2 TLR4 TLR5 TNF
13 12.16 IL6 NOD2 TLR2 TLR4 TNF
14
Show member pathways
12.11 IL6 TLR2 TLR4 TLR5 TNF
15
Show member pathways
12.1 IL17A IL6 NOD2 STAT3 TLR2 TLR4
16
Show member pathways
12.08 IL17A IL6 TNF
17 12.06 MPO TLR2 TLR4
18 12.02 IL6 STAT3 TLR2 TLR4 TLR5 TNF
19 12 TLR2 TLR4 TLR5
20 11.99 IL6 STAT3 TNF
21
Show member pathways
11.99 STAT3 TLR2 TLR4 TLR5
22 11.95 CCR3 IL6 MPO TNF
23 11.94 IL6 TLR4 TNF
24 11.93 IL17A IL6 STAT3 TNF
25
Show member pathways
11.89 IL6 STAT3 TNF
26 11.89 IL6 NOD2 TNF
27 11.84 IL6 STAT3 TNF
28 11.84 IL6 STAT3 TLR4
29 11.84 IL6 TLR2 TLR4 TNF
30
Show member pathways
11.82 IL17A IL6 STAT3 TLR4
31 11.79 IL17A IL6 TLR2 TLR4 TNF
32 11.78 IL6 TLR4 TLR5
33 11.77 TLR2 TLR4 TLR5
34 11.72 IL6 TLR4 TNF
35
Show member pathways
11.64 IL17A IL6 STAT3 TLR2 TLR4 TLR5
36 11.63 CCR3 IL6 TNF
37 11.61 IL6 TLR2 TLR4 TLR5 TNF
38 11.5 IL6 STAT3 TNF
39 11.49 IL6 MPO TNF
40 11.49 TLR2 TLR4 TNF
41 11.47 IL6 TLR2 TLR4 TNF
42 11.4 IL6 TLR2 TLR4 TLR5 TNF
43 11.3 IL6 STAT3 TLR4 TNF
44 11.29 IL17A IL6 TNF
45
Show member pathways
11.2 IL17A IL6 STAT3 TLR2 TLR4 TLR5
46 11.06 NOD2 TNF
47 11.04 IL6 TNF
48 10.97 IL6 TNF
49 10.89 MPO TNF

GO Terms for Ileitis

Cellular components related to Ileitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IL17A IL6 TLR4 TNF

Biological processes related to Ileitis according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 IL6 STAT3 TLR2 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.9 IL6 MPO TLR2 TLR4
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 IL6 NOD2 TLR4 TNF
4 defense response GO:0006952 9.85 MPO NOD2 TNF
5 defense response to bacterium GO:0042742 9.85 MPO NOD2 TLR4 TLR5 TNF
6 activation of MAPK activity GO:0000187 9.84 NOD2 TLR4 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.83 IL6 TLR4 TLR5 TNF
8 cellular response to organic cyclic compound GO:0071407 9.82 NOD2 STAT3 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.81 IL6 TLR2 TNF
10 positive regulation of JNK cascade GO:0046330 9.8 NOD2 TLR4 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL6 NOD2 TLR2 TLR4 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.76 NOD2 TLR2 TLR4
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.72 TLR2 TLR4 TLR5
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 TLR2 TLR4 TNF
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.68 NOD2 TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.68 IL17A TNF
17 positive regulation of stress-activated MAPK cascade GO:0032874 9.67 NOD2 TLR4
18 negative regulation of growth of symbiont in host GO:0044130 9.67 MPO TNF
19 positive regulation of interleukin-10 production GO:0032733 9.67 NOD2 TLR2 TLR4
20 I-kappaB phosphorylation GO:0007252 9.66 TLR2 TLR4
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.66 IL17A NOD2
22 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
23 interleukin-6-mediated signaling pathway GO:0070102 9.65 IL6 STAT3
24 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
25 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 TLR2 TLR4 TNF
26 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
27 response to yeast GO:0001878 9.63 IL6 MPO
28 T-helper 17 cell lineage commitment GO:0072540 9.62 IL6 STAT3
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL6 TLR4 TLR5 TNF
30 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 NOD2 TLR2 TLR4
32 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR2 TLR5
33 regulation of cytokine secretion GO:0050707 9.58 TLR2 TLR4 TLR5
34 cytokine secretion involved in immune response GO:0002374 9.57 NOD2 TLR2
35 positive regulation of chemokine production GO:0032722 9.56 IL6 TLR2 TLR4 TNF
36 inflammatory response GO:0006954 9.56 CCR3 IL17A IL6 STAT3 TLR2 TLR4
37 positive regulation of interleukin-6 production GO:0032755 9.55 IL6 NOD2 TLR2 TLR4 TNF
38 positive regulation of interleukin-8 production GO:0032757 9.02 NOD2 TLR2 TLR4 TLR5 TNF
39 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.05 IL17A IL6 NOD2 STAT3 TLR2 TLR4
40 immune response GO:0006955 10 IL17A IL6 TLR2 TLR4 TNF

Molecular functions related to Ileitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 8.96 NOD2 TLR2
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Ileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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