MCID: ILT001
MIFTS: 46

Ileitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ileitis

MalaCards integrated aliases for Ileitis:

Name: Ileitis 12 52 42 14 69
Crohn's Ileitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060189
ICD10 33 K52.9
MeSH 42 D007079
NCIt 47 C84782
SNOMED-CT 64 52457000
UMLS 69 C0020877

Summaries for Ileitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in ileum, has symptom diarrhea, has symptom abdominal pain, often in the right lower quadrant, has symptom weight loss.

MalaCards based summary : Ileitis, also known as crohn's ileitis, is related to crohn's disease and spondylocostal dysostosis 4. An important gene associated with Ileitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Clarithromycin and Clofazimine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, t cells and colon, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 72 Ileitis is an inflammation of the ileum, a portion of the small intestine. Crohn\'s ileitis is a type of... more...

Related Diseases for Ileitis

Diseases related to Ileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
id Related Disease Score Top Affiliating Genes
1 crohn's disease 11.4
2 spondylocostal dysostosis 4 10.7 TLR4 TNF
3 smarca4-deficient sarcoma of thorax 10.7 IL6 TNF
4 congenital insensitivity to pain with hyperhidrosis 10.7 NOD2 TLR4
5 low compliance bladder 10.7 TLR4 TNF
6 prothrombin thrombophilia 10.7 TLR2 TLR4
7 crohn's colitis 10.7 NOD2 TNF
8 aortic arch interruption 10.7 IL6 TNF
9 neuromuscular disease 10.7 NOD2 TNF
10 cutaneous leishmaniasis 10.7 IL6 TNF
11 spirillary rat-bite fever 10.7 IL6 TNF
12 saethre-chotzen syndrome 10.7 IL6 NOD2
13 toxoplasmosis 10.6 IL6 TNF
14 dyslexia 5 10.6 IL6 TNF
15 epstein-barr virus hepatitis 10.6 IL6 TNF
16 scrotal carcinoma 10.6 IL6 TNF
17 papilledema 10.6 IL6 TNF
18 lung disease 10.6 IL17A TNF
19 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
20 neutrophil-specific granule deficiency 10.6 IL17A TLR2
21 amyotrophic lateral sclerosis type 10 10.6 NOD2 TNF
22 potato nose 10.6 IL6 TNF
23 halal setton wang syndrome 10.6 TLR2 TNF
24 bipolar i disorder 10.6 IL6 TNF
25 benign eccrine breast spiradenoma 10.5 NOD2 TLR4 TNF
26 rickettsialpox 10.5 TLR2 TLR4 TNF
27 mikulicz disease 10.5 IL6 TLR4 TNF
28 iida kannari syndrome 10.5 IL6 TLR4 TNF
29 trichosporonosis 10.5 TLR2 TLR4 TNF
30 esophagus melanoma 10.5 IL6 TLR4 TNF
31 aseptic meningitis 10.5 TLR2 TLR4 TNF
32 choroiditis 10.5 IL6 TLR4 TNF
33 autosomal recessive type iv ehlers-danlos syndrome 10.5 IL6 TLR4 TNF
34 neonatal period electroclinical syndrome 10.5 IL6 TLR4 TNF
35 megaloblastic anemia 10.5 TLR2 TLR4 TNF
36 not otherwise specified 3-mga-uria type 10.5 TLR2 TNF
37 testicular infarct 10.5 TLR2 TLR4 TNF
38 bartonellosis 10.5 TLR2 TLR4 TNF
39 lymphocytic colitis 10.5 IL6 TNF
40 malignant gastric granular cell tumor 10.5 IL17A IL6
41 blue toe syndrome 10.5 IL6 TLR4 TNF
42 neovascular glaucoma 10.5 IL6 TLR4 TNF
43 sheehan syndrome 10.4 TLR2 TLR4 TNF
44 inner ear disease 10.4 IL6 TLR4 TNF
45 queensland tick typhus 10.4 IL6 NOD2 TLR2
46 tinea favosa 10.4 IL6 TNF
47 dengue disease 10.4 TLR2 TLR4 TNF
48 mucocutaneous leishmaniasis 10.4 TLR2 TLR4 TNF
49 female reproductive system disease 10.4 IL17A NOD2 TNF
50 leptospirosis 10.4 IL17A NOD2 TNF

Graphical network of the top 20 diseases related to Ileitis:



Diseases related to Ileitis

Symptoms & Phenotypes for Ileitis

MGI Mouse Phenotypes related to Ileitis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 CCR3 CSF2 FABP2 IL17A IL6 MPO
2 hematopoietic system MP:0005397 10.16 CCR3 CSF2 IL17A IL6 MPO NOD2
3 growth/size/body region MP:0005378 10.13 TLR4 TLR5 TNF CSF2 FABP2 IL17A
4 cellular MP:0005384 10.11 CCR3 CSF2 IL6 NOD2 TLR2 TLR4
5 immune system MP:0005387 10.1 CSF2 IL17A IL6 MPO NOD2 TLR2
6 adipose tissue MP:0005375 10.07 CSF2 FABP2 IL6 TLR2 TLR4 TLR5
7 digestive/alimentary MP:0005381 10.04 IL17A IL6 NOD2 TLR2 TLR4 TLR5
8 mortality/aging MP:0010768 9.97 CSF2 IL17A IL6 MPO NOD2 TLR2
9 liver/biliary system MP:0005370 9.85 FABP2 IL6 TLR2 TLR4 TLR5 TNF
10 neoplasm MP:0002006 9.65 TNF CSF2 IL6 TLR2 TLR4
11 renal/urinary system MP:0005367 9.63 CSF2 FABP2 IL17A IL6 TLR2 TLR4
12 respiratory system MP:0005388 9.56 CCR3 CSF2 IL17A IL6 TLR2 TLR4
13 skeleton MP:0005390 9.17 CSF2 IL17A IL6 NOD2 TLR2 TLR4

Drugs & Therapeutics for Ileitis

Drugs for Ileitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4 81103-11-9 84029
2
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
3
Rifabutin Approved Phase 4 72559-06-9 6323490
4
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
5 Vedolizumab Approved Phase 4 943609-66-3
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 3
10 Antitubercular Agents Phase 4,Phase 2
11 Cytochrome P-450 CYP3A Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
14 Gastrointestinal Agents Phase 4,Phase 3
15 Topoisomerase Inhibitors Phase 4
16
Adalimumab Approved Phase 3 331731-18-1 16219006
17 6-Mercaptopurine Phase 3
18 Antimetabolites Phase 3
19 Antimetabolites, Antineoplastic Phase 3
20 Antirheumatic Agents Phase 3
21 Immunosuppressive Agents Phase 3
22 Nucleic Acid Synthesis Inhibitors Phase 3
23
Alicaforsen Phase 3 185229-68-9 16197724
24
Menthol Approved Phase 2 2216-51-5 16666
25
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
26 Antibodies Phase 2,Phase 1
27 Antibodies, Monoclonal Phase 2,Phase 1
28 Immunoglobulins Phase 2,Phase 1
29
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
30 Defensins
31 Cortisol succinate
32 Hydrocortisone 17-butyrate 21-propionate
33 Hydrocortisone acetate
34 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
3 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
4 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
5 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
6 Randomized Study of Topical Alicaforsen Enema in Antibiotic Refractory Pouchitis Recruiting NCT02525523 Phase 3 Alicaforsen;Placebo
7 An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease Completed NCT01090817 Phase 2 Mesenchymal stromal cells (MSC) for infusion
8 Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease. Completed NCT02031276 Phase 2 ABBV-066;ABBV-066;Placebo
9 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
10 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2 AST-120
11 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Recruiting NCT02782325 Phase 1, Phase 2
12 FMT in Ulcerative Colitis-Associated Pouchitis Recruiting NCT02049502 Phase 2
13 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
14 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
15 Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs Completed NCT01387594 Phase 1 lumbar puncture
16 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
17 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
18 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
19 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240
20 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419
21 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Active, not recruiting NCT02828410
22 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
23 Comparing the Quality of Life of Terminal Ileitis Patients With Crohn's Disease Treated With Anti-TNF or Surgical Resection Not yet recruiting NCT02872506 Anti TNF

Search NIH Clinical Center for Ileitis

Cochrane evidence based reviews: ileitis

Genetic Tests for Ileitis

Anatomical Context for Ileitis

MalaCards organs/tissues related to Ileitis:

39
Small Intestine, T Cells, Colon, Liver, Breast, Appendix, Pituitary

Publications for Ileitis

Articles related to Ileitis:

(show top 50) (show all 141)
id Title Authors Year
1
Defective ATG16L1-mediated removal of IRE1I+ drives Crohn's disease-like ileitis. ( 28082357 )
2017
2
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
3
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A CAPENTRY Study. ( 27889847 )
2017
4
Foreign body ileitis: a histopathological mimic of Crohn's disease? ( 28689632 )
2017
5
Acute ileitis facilitates infection with multidrug resistant Pseudomonas aeruginosa in human microbiota-associated mice. ( 28115993 )
2017
6
Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? ( 28560286 )
2017
7
Aspecific ileitis: Crohn's disease or not Crohn's disease? A prospective study. ( 28161731 )
2017
8
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 28424866 )
2017
9
Chronic ileitis with transmural migration of ingested foreign body treated by laparoscopy. ( 28920530 )
2017
10
Two Cases of Capecitabine-Induced Ileitis in Patients Treated with Radiochemotherapy to the Pelvis and Review of the Literature. ( 28547118 )
2017
11
Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota. ( 28414794 )
2017
12
Fistulating Crohn's terminal ileitis involving sigmoid colon, left salpinx and urinary bladder: a laparoscopic approach - a video vignette. ( 28603931 )
2017
13
An unexpected cause of terminal ileitis. ( 27729214 )
2017
14
Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. ( 28146004 )
2017
15
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 28108786 )
2017
16
A rare case of Crohn's ileitis in a patient with constitutional mismatch repair deficiency. ( 28469372 )
2017
17
Yersinia Enterocolitica Ileitis Mimicking Pediatric Crohn's Disease. ( 28230560 )
2017
18
Backwash Is Hogwash: The Clinical Significance of Ileitis in Ulcerative Colitis. ( 28631729 )
2017
19
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial. ( 28838644 )
2017
20
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis. ( 28165466 )
2017
21
Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A Methodological Mistake. ( 28255834 )
2017
22
A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. ( 28301579 )
2017
23
Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. ( 26881175 )
2016
24
Terminal Ileitis as a Feature of Henoch-SchAPnlein Purpura Masquerading as Crohn Disease in Adults. ( 26906301 )
2016
25
A novel model for studying ileitis-induced visceral hypersensitivity in goats. ( 27716368 )
2016
26
Tuberculosis terminal ileitis: A forgotten entity mimicking Crohn's disease. ( 27672643 )
2016
27
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 27591764 )
2016
28
Isolated ileitis associated with primary sclerosing cholangitis in three patients with Crohn's disease. ( 26806276 )
2016
29
Visceral Hypersensitivity Is Provoked by 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ileitis in Rats. ( 27499743 )
2016
30
Dietary Creatine as a Possible Novel Treatment for Crohn's Ileitis. ( 28008406 )
2016
31
Emergency laparoscopic ileo-colic resection and primary intracorporeal anastomosis for Crohn's acute ileitis with free perforation and faecal peritonitis: first ever reported laparoscopic treatment. ( 26759755 )
2016
32
Clostridium difficile ileitis in a patient, after total colectomy. ( 26903365 )
2016
33
Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. ( 27848951 )
2016
34
Visceral pain triggered by traction on the ileocecal ligament with ileitis. ( 27757049 )
2016
35
Frequency, natural course and clinical significance of symptomatic terminal ileitis. ( 26670338 )
2016
36
Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. ( 27581119 )
2016
37
Relapsing Olmesartan-Associated Ileitis. ( 27539736 )
2016
38
IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis. ( 26908008 )
2016
39
Capsule Endoscopy for Ileitis with Potential Involvement of Other Sections of the Small Bowel. ( 26880904 )
2016
40
Sequential Crohn's Ileitis, Ileosigmoidal Fistula, Segmental Sigmoid Polyposis, and Sigmoid Stricture: The Natural History. ( 27466165 )
2016
41
Prospective Evaluation of Terminal Ileitis in a Surveillance Population of Patients with Ulcerative Colitis. ( 27580386 )
2016
42
Multiples ileal adenomas in Crohn's disease: Sporadic or ileitis associated dysplasia? ( 28040346 )
2016
43
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium. ( 27930931 )
2016
44
Facing Terminal Ileitis: Going Beyond Crohn's Disease. ( 27785317 )
2016
45
Dysregulated intrahepatic CD4(+) T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. ( 26213712 )
2015
46
SAMP1/YitFc Mice Develop Ileitis via Loss of CCL21 and Defects in Dendritic Cell Migration. ( 25620669 )
2015
47
Toll-like receptor (TLR) 2 agonists ameliorate indomethacin-induced murine ileitis by suppressing the TLR4 signaling. ( 25867219 )
2015
48
Terminal ileitis induced by Henoch-Schonlein purpura that presented as acute appendicitis: a case report. ( 25654396 )
2015
49
Pancreatic heterotopia of small intestine with tubercular ileitis. ( 25737997 )
2015
50
Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. ( 25887379 )
2015

Variations for Ileitis

Expression for Ileitis

Search GEO for disease gene expression data for Ileitis.

Pathways for Ileitis

Pathways related to Ileitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CSF2 IL17A IL6 MPO NOD2 TLR2
2
Show member pathways
13.3 CCR3 CSF2 IL17A IL6 TLR2 TLR4
3
Show member pathways
12.9 IL6 NOD2 TLR2 TLR4 TLR5 TNF
4
Show member pathways
12.81 IL6 TLR2 TLR4 TLR5 TNF
5
Show member pathways
12.7 IL6 TLR2 TLR4 TNF
6
Show member pathways
12.63 IL6 TLR2 TLR4 TLR5 TNF
7
Show member pathways
12.53 TLR2 TLR4 TLR5 TNF
8
Show member pathways
12.51 IL17A IL6 MPO TNF
9 12.46 IL17A MPO TLR2 TNF
10
Show member pathways
12.36 CSF2 IL17A IL6 TNF
11
Show member pathways
12.34 IL17A IL6 NOD2 TLR2 TLR4 TLR5
12
Show member pathways
12.18 IL6 TLR4 TNF
13
Show member pathways
12.18 CSF2 IL17A IL6 TLR2 TLR5 TNF
14 12.17 IL6 NOD2 TLR2 TLR4 TNF
15
Show member pathways
12.13 IL6 TLR2 TLR4 TLR5 TNF
16 12.11 IL6 TLR2 TLR4 TLR5 TNF
17
Show member pathways
12.07 IL17A IL6 TNF
18 12.05 MPO TLR2 TLR4
19 12 TLR2 TLR4 TLR5
20
Show member pathways
11.95 TLR2 TLR4 TLR5
21 11.93 IL6 TLR4 TNF
22 11.92 CCR3 CSF2 IL6 MPO TNF
23 11.91 IL17A IL6 TNF
24 11.91 CSF2 IL6 NOD2 TNF
25
Show member pathways
11.84 CSF2 IL17A IL6 TLR4
26 11.83 CSF2 IL6 TNF
27 11.81 CSF2 IL6 TLR2 TLR4 TNF
28
Show member pathways
11.81 IL17A IL6 TLR2 TLR4 TLR5
29 11.79 CSF2 IL6 TLR4 TLR5
30 11.76 TLR2 TLR4 TLR5
31 11.71 IL6 TLR4 TNF
32 11.71 CSF2 IL6 TNF
33 11.64 CCR3 CSF2 IL6 TNF
34
Show member pathways
11.62 CSF2 IL6 TNF
35 11.56 IL6 TLR2 TLR4 TLR5 TNF
36 11.5 CSF2 IL6 TNF
37 11.49 IL6 MPO TNF
38 11.48 TLR2 TLR4 TNF
39 11.47 IL6 TLR2 TLR4 TNF
40
Show member pathways
11.46 IL17A IL6 TLR2 TLR4 TLR5 TNF
41 11.33 IL6 TLR4 TNF
42 11.29 IL6 TLR2 TLR4 TLR5 TNF
43 11.28 IL17A IL6 TNF
44 11.24 CSF2 IL6 TNF
45 11.15 CSF2 IL17A IL6 TNF
46 11.1 CCR3 TLR2
47 11.06 NOD2 TNF
48 11.05 CSF2 IL17A IL6 TLR2 TLR4 TNF
49 11.04 IL6 TNF
50 10.97 IL6 TNF

GO Terms for Ileitis

Cellular components related to Ileitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IL17A IL6 TLR4 TNF

Biological processes related to Ileitis according to GeneCards Suite gene sharing:

(show all 43)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 NOD2 TLR2 TLR4 TLR5
2 immune response GO:0006955 9.99 CSF2 IL17A IL6 TLR2 TLR4 TNF
3 positive regulation of gene expression GO:0010628 9.97 CSF2 IL6 TLR2 TLR4 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 IL6 NOD2 TLR4 TNF
5 response to lipopolysaccharide GO:0032496 9.9 IL6 MPO TLR2 TLR4
6 defense response to bacterium GO:0042742 9.88 MPO NOD2 TLR4 TLR5 TNF
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 NOD2 TLR4 TNF
8 defense response GO:0006952 9.85 MPO NOD2 TNF
9 activation of MAPK activity GO:0000187 9.84 NOD2 TLR4 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 TLR2 TNF
11 positive regulation of JNK cascade GO:0046330 9.8 NOD2 TLR4 TNF
12 inflammatory response GO:0006954 9.8 CCR3 IL17A IL6 TLR2 TLR4 TLR5
13 positive regulation of tumor necrosis factor production GO:0032760 9.77 NOD2 TLR2 TLR4
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL6 NOD2 TLR2 TLR4 TNF
15 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.73 TLR2 TLR4 TLR5
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TLR2 TLR4 TNF
17 cellular response to lipopolysaccharide GO:0071222 9.72 CSF2 IL6 TLR4 TLR5 TNF
18 positive regulation of interleukin-10 production GO:0032733 9.71 NOD2 TLR2 TLR4
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 IL6 TLR4 TLR5 TNF
20 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 TLR2 TLR4 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.69 TLR2 TLR4
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.68 NOD2 TNF
23 positive regulation of osteoclast differentiation GO:0045672 9.68 IL17A TNF
24 positive regulation of stress-activated MAPK cascade GO:0032874 9.67 NOD2 TLR4
25 negative regulation of growth of symbiont in host GO:0044130 9.67 MPO TNF
26 I-kappaB phosphorylation GO:0007252 9.66 TLR2 TLR4
27 positive regulation of podosome assembly GO:0071803 9.66 CSF2 TNF
28 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
29 macrophage activation GO:0042116 9.65 CSF2 TLR4
30 negative regulation of lipid storage GO:0010888 9.64 IL6 TNF
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 NOD2 TLR2 TLR4
33 response to yeast GO:0001878 9.62 IL6 MPO
34 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.62 IL6 TNF
35 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IL17A
36 regulation of cytokine secretion GO:0050707 9.61 TLR2 TLR4 TLR5
37 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR2 TLR5
38 cytokine secretion involved in immune response GO:0002374 9.58 NOD2 TLR2
39 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 IL17A NOD2
40 positive regulation of chemokine production GO:0032722 9.46 IL6 TLR2 TLR4 TNF
41 positive regulation of interleukin-6 production GO:0032755 9.35 IL6 NOD2 TLR2 TLR4 TNF
42 positive regulation of interleukin-8 production GO:0032757 9.02 NOD2 TLR2 TLR4 TLR5 TNF
43 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.11 IL17A IL6 NOD2 TLR2 TLR4 TNF

Molecular functions related to Ileitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CSF2 IL17A IL6 TNF
2 peptidoglycan binding GO:0042834 9.16 NOD2 TLR2
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Ileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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