Aliases & Classifications for Ileocolitis

MalaCards integrated aliases for Ileocolitis:

Name: Ileocolitis 12 14
Iieocolitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060190
ICD10 32 K52.9
UMLS 69 C0949272

Summaries for Ileocolitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon and located in ileum, has symptom diarrhea, has symptom weight loss, has symptom abdominal pain in middle or lower right part.

MalaCards based summary : Ileocolitis, also known as iieocolitis, is related to cytomegalovirus infection and crohn's colitis, and has symptoms including diarrhea, weight loss and abdominal pain in middle or lower right part. An important gene associated with Ileocolitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. The drugs Azathioprine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include colon, ileum and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Ileocolitis

Diseases related to Ileocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 29.8 IL2RA TNF
2 crohn's colitis 29.7 NOD2 TNF
3 ileitis 29.6 NOD2 TNF
4 colitis 29.5 MYO9B NOD2 TNF
5 crohn's disease 29.3 DLG5 NOD2 TNF
6 ulcerative colitis 29.1 MYO9B NOD2 TNF
7 intussusception 10.5
8 anterior uveitis 10.3 IL2RA TNF
9 posterior uveitis 10.3 IL2RA TNF
10 intermediate uveitis 10.3 IL2RA TNF
11 stromal keratitis 10.3 IL2RA TNF
12 oligoarticular juvenile idiopathic arthritis 10.3 IL2RA TNF
13 idiopathic neutropenia 10.2 IL2RA TNF
14 brucellosis 10.2 IL2RA TNF
15 pulmonary sarcoidosis 10.2 IL2RA TNF
16 granulomatous dermatitis 10.2 NOD2 TNF
17 inflammatory bowel disease 3 10.1 NOD2 TNF
18 streptococcal meningitis 10.1 NOD2 TNF
19 blau syndrome 10.1 NOD2 TNF
20 lymphoma 10.1
21 hidradenitis suppurativa 10.1 NOD2 TNF
22 hidradenitis 10.1 NOD2 TNF
23 pyoderma gangrenosum 10.1 NOD2 TNF
24 juvenile rheumatoid arthritis 10.1 IL2RA TNF
25 pyoderma 10.1 NOD2 TNF
26 hypersensitivity reaction type iv disease 10.1 NOD2 TNF
27 alopecia areata 10.1 IL2RA TNF
28 leprosy 3 10.0 NOD2 TNF
29 spondyloarthropathy 1 10.0 NOD2 TNF
30 inflammatory bowel disease 6 10.0 MYO9B NOD2
31 lymphadenitis 10.0 NOD2 TNF
32 rheumatic disease 10.0 IL2RA TNF
33 familial mediterranean fever 10.0 NOD2 TNF
34 lipomatosis, multiple 10.0
35 intestinal disease 10.0 NOD2 TNF
36 spondylitis 10.0 NOD2 TNF
37 intestinal obstruction 9.9
38 acquired immunodeficiency syndrome 9.9 IL2RA TNF
39 burkitt lymphoma 9.9
40 sarcoma 9.9
41 acute graft versus host disease 9.9 IL2RA NOD2 TNF
42 uveitis 9.9 IL2RA NOD2 TNF
43 sarcoidosis 1 9.9 IL2RA NOD2 TNF
44 behcet syndrome 9.8 IL2RA NOD2 TNF
45 inflammatory bowel disease 2 9.8 DLG5 NOD2
46 autism 9.8
47 aging 9.8
48 autism spectrum disorder 9.8
49 megacolon 9.8
50 melanoma 9.8

Graphical network of the top 20 diseases related to Ileocolitis:



Diseases related to Ileocolitis

Symptoms & Phenotypes for Ileocolitis

Symptoms:

12
  • diarrhea
  • weight loss
  • abdominal pain in middle or lower right part

GenomeRNAi Phenotypes related to Ileocolitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 IL2RA MYO9B NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 IL2RA MYO9B NOD2 TNF

MGI Mouse Phenotypes related to Ileocolitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 DLG5 GPX1 IL2RA MYO9B NOD2 TNF
2 homeostasis/metabolism MP:0005376 9.1 DLG5 DNAJC17 GPX1 IL2RA NOD2 TNF

Drugs & Therapeutics for Ileocolitis

Drugs for Ileocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 3 446-86-6 2265
2
Certolizumab pegol Approved Phase 3 428863-50-7
3
Adalimumab Approved Phase 3 331731-18-1 16219006
4 Antimetabolites Phase 3
5 Antimetabolites, Antineoplastic Phase 3
6 Antirheumatic Agents Phase 3
7 Immunosuppressive Agents Phase 3
8 6-Mercaptopurine Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
2 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
3 Safety Study of P28GST Treatment in Crohn's Disease Patients Recruiting NCT02281916 Phase 2 P28GST
4 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240

Search NIH Clinical Center for Ileocolitis

Genetic Tests for Ileocolitis

Anatomical Context for Ileocolitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ileocolitis:

18
Colon, Ileum

MalaCards organs/tissues related to Ileocolitis:

38
Skin, Colon, Eye, Pituitary, Small Intestine, Lymph Node

Publications for Ileocolitis

Articles related to Ileocolitis:

(show top 50) (show all 98)
# Title Authors Year
1
Fever as a Presenting Symptom in Children Evaluated for Ileocolic Intussusception: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337836 )
2018
2
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI findings. ( 28084260 )
2017
3
Granulomas in mesenteric lymph nodes in Crohn's disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. ( 28087973 )
2017
4
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. ( 28647362 )
2017
5
Adult ileocolic intussusception caused by Burkitt lymphoma. ( 27920022 )
2016
6
Fatal Campylobacter jejuni ileocolitis. ( 27701889 )
2016
7
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27670550 )
2016
8
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. ( 27767057 )
2016
9
Intestinal Obstruction Caused by Ileocolic and Colocolic Intussusception in an Adult Patient with Cecal Lipoma. ( 28044120 )
2016
10
Intestinal Obstruction and Ileocolic Fistula due to Intraluminal Migration of a Gossypiboma. ( 26989551 )
2016
11
Concomitant Laparoscopic Ileocolectomy and Ladds Procedure for Crohns Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27930275 )
2016
12
Giant ileocolic intussusception in an adult induced by a double ileal lipoma: a case report with pathologic correlation. ( 27594938 )
2016
13
Cytomegalovirus ileocolitis in a rheumatoid arthritis patient: case report and literature review. ( 26150269 )
2015
14
Ulcerating Ileocolitis in Severe Amatoxin Poisoning. ( 26357578 )
2015
15
Eosinophilic ileocolitis due to Enterobius vermicularis infection: a rare cause of anemia. ( 25976928 )
2015
16
Ileocaecal Lymphoma Presenting as Ileocolic Intussesception in a 7 Year Old Male. ( 27217691 )
2015
17
Abdominal pain and ileocolitis in a 51-year-old woman. ( 25529814 )
2015
18
Fecal Microbial Transplant After Ileocolic Resection Reduces Ileitis but Restores Colitis in IL-10-/- Mice. ( 26070001 )
2015
19
P286. Prevalence of Ulcerative Colitis and Crohn ileocolitis in patients with celiac disease. ( 25717762 )
2015
20
Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. ( 24374371 )
2014
21
An ileal duplication cyst manifested as an ileocolic intussusception in an adult. ( 25910304 )
2014
22
Indolent systemic mastocytosis in a patient with ileocolitis. ( 24975749 )
2014
23
Total ileocolic intussusception with rectal prolapse presenting in an adult: a case report and review of the literature. ( 24059349 )
2013
24
Gastrointestinal Kaposi's Sarcoma Presenting as Ileocolic Intussusception. ( 24404547 )
2013
25
Diarrhoea in a patient with metastatic melanoma: Ipilimumab ileocolitis treated with infliximab. ( 23919220 )
2013
26
Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases. ( 23007968 )
2013
27
Historical note on Crohn's disease: first US pre-eponym journal report of chronic regional ileocolitis in 1813. ( 23269223 )
2013
28
Ileocolic intussusception due to Burkitt lymphoma: a case report. ( 23599821 )
2013
29
Crohn's disease recurrence in patients with ileocolic anastomosis: value of computed tomography enterography with water enema. ( 23727378 )
2013
30
Therapeutic enema for pediatric ileocolic intussusception: using a balloon catheter improves efficacy. ( 23748969 )
2013
31
Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. ( 23520485 )
2013
32
Ileocolic to right iliac arterial transposition for the treatment of chronic mesenteric ischemia. ( 24436624 )
2013
33
Adenocarcinoma of the ileocolic junction and multifocal hepatic sarcomas in an aged rhesus macaque (Macaca mulatta). ( 24209973 )
2013
34
Endoscopic treatment of a symptomatic ileal lipoma with recurrent ileocolic intussusceptions by using cap-assisted colonoscopy. ( 23964343 )
2013
35
Ileocolic intussusception secondary to a type II low-grade appendiceal mucinous neoplasm. ( 23351140 )
2013
36
Single port laparoscopic right hemicolectomy for ileocolic intussusception. ( 23538552 )
2013
37
Successful treatment of ileocolic intussusception with air enema reduction in an adult patient. ( 24332898 )
2013
38
Ileocolic versus small-bowel intussusception in children: can US enable reliable differentiation? ( 23801771 )
2013
39
Ultrasound guided reduction of an ileocolic intussusception by a hydrostatic method by using normal saline enema in paediatric patients: a study of 30 cases. ( 23373037 )
2012
40
Ileocolic intussusception and hydrostatic reduction in a 2-year-old girl. ( 23188872 )
2012
41
Ileocolic intussusception due to giant ileal lipoma: Review of literature and report of a case. ( 22622130 )
2012
42
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. ( 22178590 )
2012
43
Ileocolic intussusception precipitated by diagnostic colonoscopy: a case report. ( 22678343 )
2012
44
External manual reduction of paediatric idiopathic ileocolic intussusception with US assistance: a new, standardised, effective and safe manoeuvre. ( 22875204 )
2012
45
Ileocolic intussusception due to an inverted Meckel's diverticulum. ( 21752739 )
2012
46
Ileocolic intussusception due to a gastrointestinal stromal tumor. ( 22505390 )
2012
47
Idiopathic adult ileoileal and ileocolic intussusception in situs inversus totalis: a rare coincidence. ( 22249097 )
2012
48
Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease. ( 23044675 )
2012
49
Use of cecal bypass via side-to-side ileocolic anastomosis without ileal transection for treatment of ileocecal intussusception in a Vietnamese pot-bellied pig (Sus scrofa). ( 22765371 )
2012
50
Ileocolic intussusception. ( 22902852 )
2012

Variations for Ileocolitis

Expression for Ileocolitis

Search GEO for disease gene expression data for Ileocolitis.

Pathways for Ileocolitis

GO Terms for Ileocolitis

Biological processes related to Ileocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.65 DLG5 MYO9B NOD2
2 cellular response to organic cyclic compound GO:0071407 9.46 NOD2 TNF
3 regulation of inflammatory response GO:0050727 9.43 NOD2 TNF
4 positive regulation of JNK cascade GO:0046330 9.4 NOD2 TNF
5 positive regulation of MAP kinase activity GO:0043406 9.37 NOD2 TNF
6 JNK cascade GO:0007254 9.32 NOD2 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.26 NOD2 TNF
8 negative regulation of T cell proliferation GO:0042130 9.16 DLG5 IL2RA
9 positive regulation of interleukin-8 production GO:0032757 8.96 NOD2 TNF
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 8.62 NOD2 TNF

Sources for Ileocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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