MCID: ILC002
MIFTS: 34

Ileocolitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ileocolitis

MalaCards integrated aliases for Ileocolitis:

Name: Ileocolitis 12 14
Iieocolitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060190
ICD10 33 K52.9

Summaries for Ileocolitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon and located in ileum, has symptom diarrhea, has symptom weight loss, has symptom abdominal pain in middle or lower right part.

MalaCards based summary : Ileocolitis, also known as iieocolitis, is related to leptospirosis and crohn's colitis. An important gene associated with Ileocolitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. The drugs Azathioprine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Wikipedia : 72 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Ileocolitis

Diseases related to Ileocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
id Related Disease Score Top Affiliating Genes
1 leptospirosis 29.6 NOD2 TNF
2 crohn's colitis 25.6 DLG5 DNAJC17 GPX1 IL2RA MYO9B NOD2
3 crohn's disease 11.2
4 autoimmune retinopathy 10.5 IL2RA TNF
5 atypical lichen myxedematosus 10.5 IL2RA TNF
6 parametritis 10.5 IL2RA TNF
7 atrichia with papular lesions 10.4 IL2RA TNF
8 cyclosporiasis 10.4 IL2RA TNF
9 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.4 IL2RA TNF
10 dysphagia 10.4 IL2RA TNF
11 intussusception 10.4
12 iida kannari syndrome 10.3 IL2RA TNF
13 esophagus melanoma 10.3 IL2RA TNF
14 left bundle branch hemiblock 10.3 IL2RA TNF
15 neuromuscular disease 10.3 NOD2 TNF
16 intestinal disaccharidase deficiency 10.3 IL2RA TNF
17 amyotrophic lateral sclerosis type 10 10.2 NOD2 TNF
18 deafness, autosomal recessive 67 10.2 NOD2 TNF
19 renal tubular acidosis 10.2 IL2RA TNF
20 female reproductive system disease 10.2 NOD2 TNF
21 functional gastric disease 10.2 NOD2 TNF
22 yao syndrome 10.2 NOD2 TNF
23 lip cancer 10.2 NOD2 TNF
24 myopathy 10.2 NOD2 TNF
25 gastroduodenal crohn's disease 10.1 NOD2 TNF
26 membranoproliferative glomerulonephritis 10.1 NOD2 TNF
27 respiratory system disease 10.1 IL2RA TNF
28 psoriasis susceptibility 1 10.1 NOD2 TNF
29 migraine with or without aura 5 10.1 MYO9B NOD2
30 lymphoma 10.0
31 benign eccrine breast spiradenoma 10.0 NOD2 TNF
32 acral lentiginous melanoma 10.0 IL2RA TNF
33 muscle tissue disease 9.9 NOD2 TNF
34 acute monoblastic leukemia 9.9 IL2RA NOD2 TNF
35 inflammatory bowel disease 3 9.9 IL2RA NOD2 TNF
36 esophageal candidiasis 9.9 IL2RA NOD2 TNF
37 tuberculum sellae meningioma 9.9 NOD2 TNF
38 goodpasture syndrome 9.8 IL2RA NOD2 TNF
39 intestinal obstruction 9.8
40 klippel-feil syndrome 3, autosomal dominant 9.8 DLG5 NOD2
41 colitis 9.8
42 burkitt lymphoma 9.8
43 sarcoma 9.8
44 kaposi sarcoma 9.8 IL2RA TNF
45 vocal cord scarring 9.7 MYO9B NOD2 TNF
46 microscopic colitis 9.7 MYO9B NOD2 TNF
47 duodenitis 9.7
48 gastroenteritis 9.7
49 endometriosis 9.7
50 meckel's diverticulum 9.7

Graphical network of the top 20 diseases related to Ileocolitis:



Diseases related to Ileocolitis

Symptoms & Phenotypes for Ileocolitis

GenomeRNAi Phenotypes related to Ileocolitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 NOD2 TNF IL2RA MYO9B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 NOD2 TNF IL2RA MYO9B

MGI Mouse Phenotypes related to Ileocolitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 DLG5 GPX1 IL2RA MYO9B NOD2 TNF

Drugs & Therapeutics for Ileocolitis

Drugs for Ileocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 3 446-86-6 2265
2
Certolizumab pegol Approved Phase 3 428863-50-7
3
Adalimumab Approved Phase 3 331731-18-1 16219006
4 Antimetabolites Phase 3
5 Antimetabolites, Antineoplastic Phase 3
6 Antirheumatic Agents Phase 3
7 Immunosuppressive Agents Phase 3
8 6-Mercaptopurine Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
2 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
3 Safety Study of P28GST Treatment in Crohn's Disease Patients Recruiting NCT02281916 Phase 2 P28GST
4 Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis Recruiting NCT03256240

Search NIH Clinical Center for Ileocolitis

Genetic Tests for Ileocolitis

Anatomical Context for Ileocolitis

MalaCards organs/tissues related to Ileocolitis:

39
Skin, Colon, Eye, Pituitary, Small Intestine, Lymph Node

Publications for Ileocolitis

Articles related to Ileocolitis:

(show top 50) (show all 97)
id Title Authors Year
1
Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice. ( 28647362 )
2017
2
Granulomas in mesenteric lymph nodes in Crohn's disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. ( 28087973 )
2017
3
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI findings. ( 28084260 )
2017
4
Concomitant Laparoscopic Ileocolectomy and Ladd's Procedure for Crohn's Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27670550 )
2016
5
Giant ileocolic intussusception in an adult induced by a double ileal lipoma: a case report with pathologic correlation. ( 27594938 )
2016
6
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. ( 27767057 )
2016
7
Adult ileocolic intussusception caused by Burkitt lymphoma. ( 27920022 )
2016
8
Fatal Campylobacter jejuni ileocolitis. ( 27701889 )
2016
9
Intestinal Obstruction Caused by Ileocolic and Colocolic Intussusception in an Adult Patient with Cecal Lipoma. ( 28044120 )
2016
10
Concomitant Laparoscopic Ileocolectomy and Ladds Procedure for Crohns Ileocolitis with Mesenteric Abscess and Congenital Megacolon. ( 27930275 )
2016
11
Intestinal Obstruction and Ileocolic Fistula due to Intraluminal Migration of a Gossypiboma. ( 26989551 )
2016
12
Ileocaecal Lymphoma Presenting as Ileocolic Intussesception in a 7 Year Old Male. ( 27217691 )
2015
13
Cytomegalovirus ileocolitis in a rheumatoid arthritis patient: case report and literature review. ( 26150269 )
2015
14
Abdominal pain and ileocolitis in a 51-year-old woman. ( 25529814 )
2015
15
Ulcerating Ileocolitis in Severe Amatoxin Poisoning. ( 26357578 )
2015
16
P286. Prevalence of Ulcerative Colitis and Crohn ileocolitis in patients with celiac disease. ( 25717762 )
2015
17
Fecal Microbial Transplant After Ileocolic Resection Reduces Ileitis but Restores Colitis in IL-10-/- Mice. ( 26070001 )
2015
18
Eosinophilic ileocolitis due to Enterobius vermicularis infection: a rare cause of anemia. ( 25976928 )
2015
19
Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2. ( 24374371 )
2014
20
Indolent systemic mastocytosis in a patient with ileocolitis. ( 24975749 )
2014
21
An ileal duplication cyst manifested as an ileocolic intussusception in an adult. ( 25910304 )
2014
22
Single port laparoscopic right hemicolectomy for ileocolic intussusception. ( 23538552 )
2013
23
Ileocolic intussusception due to Burkitt lymphoma: a case report. ( 23599821 )
2013
24
Diarrhoea in a patient with metastatic melanoma: Ipilimumab ileocolitis treated with infliximab. ( 23919220 )
2013
25
Therapeutic enema for pediatric ileocolic intussusception: using a balloon catheter improves efficacy. ( 23748969 )
2013
26
Adenocarcinoma of the ileocolic junction and multifocal hepatic sarcomas in an aged rhesus macaque (Macaca mulatta). ( 24209973 )
2013
27
Successful treatment of ileocolic intussusception with air enema reduction in an adult patient. ( 24332898 )
2013
28
Historical note on Crohn's disease: first US pre-eponym journal report of chronic regional ileocolitis in 1813. ( 23269223 )
2013
29
Gastrointestinal Kaposi's Sarcoma Presenting as Ileocolic Intussusception. ( 24404547 )
2013
30
Total ileocolic intussusception with rectal prolapse presenting in an adult: a case report and review of the literature. ( 24059349 )
2013
31
Endoscopic treatment of a symptomatic ileal lipoma with recurrent ileocolic intussusceptions by using cap-assisted colonoscopy. ( 23964343 )
2013
32
Ileocolic to right iliac arterial transposition for the treatment of chronic mesenteric ischemia. ( 24436624 )
2013
33
Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases. ( 23007968 )
2013
34
Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. ( 23520485 )
2013
35
Ileocolic versus small-bowel intussusception in children: can US enable reliable differentiation? ( 23801771 )
2013
36
Crohn's disease recurrence in patients with ileocolic anastomosis: value of computed tomography enterography with water enema. ( 23727378 )
2013
37
Ileocolic intussusception secondary to a type II low-grade appendiceal mucinous neoplasm. ( 23351140 )
2013
38
Use of cecal bypass via side-to-side ileocolic anastomosis without ileal transection for treatment of ileocecal intussusception in a Vietnamese pot-bellied pig (Sus scrofa). ( 22765371 )
2012
39
Appendiceal intussusception masquerading as an ileocolic intussusception. ( 22370734 )
2012
40
External manual reduction of paediatric idiopathic ileocolic intussusception with US assistance: a new, standardised, effective and safe manoeuvre. ( 22875204 )
2012
41
External manual reduction of paediatric idiopathic ileocolic intussusception with ultrasound assistance. ( 22875207 )
2012
42
Idiopathic adult ileoileal and ileocolic intussusception in situs inversus totalis: a rare coincidence. ( 22249097 )
2012
43
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. ( 22178590 )
2012
44
Ileocolic intussusception due to a gastrointestinal stromal tumor. ( 22505390 )
2012
45
Ileocolic intussusception due to an inverted Meckel's diverticulum. ( 21752739 )
2012
46
Ultrasound guided reduction of an ileocolic intussusception by a hydrostatic method by using normal saline enema in paediatric patients: a study of 30 cases. ( 23373037 )
2012
47
Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease. ( 23044675 )
2012
48
Ileocolic intussusception precipitated by diagnostic colonoscopy: a case report. ( 22678343 )
2012
49
Strangulating ileocolic intussusception in pregnancy. ( 24293856 )
2012
50
Ileocolic mucormycosis causing intestinal obstruction. ( 22885215 )
2012

Variations for Ileocolitis

Expression for Ileocolitis

Search GEO for disease gene expression data for Ileocolitis.

Pathways for Ileocolitis

GO Terms for Ileocolitis

Biological processes related to Ileocolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.61 DLG5 MYO9B NOD2
2 cellular response to organic cyclic compound GO:0071407 9.4 NOD2 TNF
3 positive regulation of JNK cascade GO:0046330 9.37 NOD2 TNF
4 JNK cascade GO:0007254 9.32 NOD2 TNF
5 positive regulation of interleukin-6 production GO:0032755 9.26 NOD2 TNF
6 negative regulation of T cell proliferation GO:0042130 9.16 DLG5 IL2RA
7 positive regulation of interleukin-8 production GO:0032757 8.96 NOD2 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 8.62 NOD2 TNF

Sources for Ileocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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