MCID: IMM001
MIFTS: 50

Immune-Complex Glomerulonephritis malady

Immune diseases category

Summaries for Immune-Complex Glomerulonephritis

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MalaCards: Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to glomerulonephritis and membranous glomerulonephritis. An important gene associated with Immune-Complex Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are Malaria and Classical antibody-mediated complement activation. The compounds kininogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Immune-Complex Glomerulonephritis

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

immune-complex glomerulonephritis 8 60
immune complex glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:4784
SNOMED-CT56 123752003
NCIt39 C35800

Related Diseases for Immune-Complex Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9ALB, VCAM1, CFI, CD40LG, OXA1L, MPO
2membranous glomerulonephritis30.8ALB, CCR5
3proliferative glomerulonephritis30.8SELP
4proteinuria30.7MPO, CD40LG, ALB
5leukemia30.6CCR1, ICAM1, ITGAL, MPO, OXA1L, CD40LG
6vasculitis30.5ICAM1, MPO, CD40LG, CFI, VCAM1, SELP
7hepatitis30.5CD40LG
8nephrotic syndrome30.5CFI, ALB
9thrombocytopenia30.3ALB, SELP, CD40LG
10hepatitis c30.3CCR5, FTH1, CD40LG, ALB
11diabetes mellitus30.3ICAM1, OXA1L, FTH1, CD40LG, VCAM1, SELP
12crohn's disease30.1ALB
13skin disease30.1MPO, ALB
14pneumonia30.1OXA1L, MPO, ICAM1
15hepatitis b30.1ITGAL, OXA1L, ALB
16tuberculosis30.1CCR1, ITGAL, ALB
17sarcoidosis30.1CCR5, ICAM1, SELP
18diabetic nephropathy30.1CCR1, OXA1L, ALB
19graves' disease30.1CCR5, ICAM1, ITGAL, MPO, VCAM1
20connective tissue disease30.1ICAM1, MPO, CD40LG, VCAM1, ALB
21arthritis30.1CCR5, CCR1, ICAM1, MPO, FTH1, ALB
22rheumatoid arthritis30.1CCR5, CCR1, ICAM1, ITGAL, MPO, OXA1L
23aleutian mink disease10.3
24complement deficiency10.3
25amyloidosis10.3
26endocarditis10.3
27leprosy10.3
28thyroiditis10.3
29ureteral obstruction10.1
30chronic granulomatous disease10.1
31hepatitis e10.1
32mixed connective tissue disease10.1
33complement factor i deficiency10.1
34hemosiderosis10.1
35anti-basement membrane glomerulonephritis10.1
36fanconi syndrome10.1
37bone lymphoma10.1
38lepromatous leprosy10.1
39c3 deficiency10.1
40celiac disease10.1
41sialadenitis10.1
42morbid obesity10.1
43lymphosarcoma10.1
44cryptococcosis10.1
45porokeratosis10.1
46acne10.1
47diffuse glomerulonephritis10.1
48filariasis10.1
49hypothyroidism10.1
50myasthenia gravis10.1

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to immune-complex glomerulonephritis

Clinical Features for Immune-Complex Glomerulonephritis

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Drugs & Therapeutics for Immune-Complex Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Immune-Complex Glomerulonephritis

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Anatomical Context for Immune-Complex Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

32
Kidney, T cells, Bone, Bone marrow, Liver, Monocytes, Thyroid, Spleen, Skin, Myeloid

Animal Models for Immune-Complex Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4CFI, C4B
2MP:00053708.3CCR5, CCR1, C4B, FTH1, SELP, ALB
3MP:00053847.6CCR1, ICAM1, ITGAL, FTH1, CD40LG, VCAM1
4MP:00053857.5CCR5, CCR1, ICAM1, C4B, MPO, FTH1
5MP:00107687.0CCR5, CCR1, ICAM1, C4B, MPO, FTH1
6MP:00053976.9C4B, ICAM1, CCR1, CCR5, ITGAL, MPO
7MP:00053876.9C4B, ICAM1, CCR1, CCR5, ITGAL, MPO
8MP:00053766.3ALB, CCR5, CCR1, ICAM1, C4B, ITGAL

Publications for Immune-Complex Glomerulonephritis

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50PubMed
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Articles related to Immune-Complex Glomerulonephritis:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis. (23788594)
2013
2
Immune-complex deposits in pANCA glomerulonephritis: a pediatric case report. (23771091)
2013
3
Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. (20702729)
2010
4
An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). (18752546)
2008
5
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. (16541204)
2007
6
Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis. (16948132)
2006
7
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. (15780090)
2005
8
Immune complex type crescentic glomerulonephritis and ANCA-positivity in a nine-year-old girl. (12026211)
2002
9
Fatal pulmonary-renal syndrome manifested with immune complex crescentic glomerulonephritis in a patient with MPO-ANCA seropositivity. (11519085)
2001
10
Immune complex glomerulonephritis in patients coinfected with human immunodeficiency virus and hepatitis C virus. (9100039)
1997
11
Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. (7543622)
1995
12
Cytokine-induced neutrophil chemoattractant mediates neutrophil influx in immune complex glomerulonephritis in rat. (8040275)
1994
13
Effect of thrombocytopenia on the onset of immune complex glomerulonephritis. (1738413)
1992
14
Effect of the immunosuppressive agent, ciclosporin, on experimental immune complex glomerulonephritis in rats. (1826940)
1991
15
Effects of thromboxane synthetase inhibition on immune complex glomerulonephritis. (1827969)
1991
16
Glomerular nitrite synthesis in in situ immune complex glomerulonephritis in the rat. (1951626)
1991
17
Immune complex glomerulonephritis associated with an amoebic liver abscess. (2148038)
1990
18
Effect of the anticomplementary agent, K-76 monocarboxylic acid, on experimental immune complex glomerulonephritis in rats. (3497741)
1987
19
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
20
The effect of protamine sulfate on the course of immune complex glomerulonephritis in the rat. (2943540)
1986
21
Intrapulmonary hemorrhages and immune complex glomerulonephritis masquerading as Goodpasture's syndrome. (2941355)
1986
22
Immune complex glomerulonephritis in a cat with renal lymphosarcoma. (3890347)
1985
23
Failure of affinity maturation leads to increased susceptibility to immune complex glomerulonephritis. (6234231)
1984
24
Rheumatoid arthritis and membranous glomerulonephritis: a role for immune complex dissociative techniques. (6376800)
1984
25
Treatment of murine immune complex glomerulonephritis with prostaglandin E2: dose--response of immune complex deposition, antibody synthesis, and glomerular damage. (6575881)
1983
26
Localization of the membrane attack complex (MAC) in experimental immune complex glomerulonephritis. (6343549)
1983
27
Immune complex glomerulonephritis and chronic anaerobic urinary infection--complications of filariasis. (6227878)
1983
28
Nephrotic syndrome and immune complex glomerulonephritis associated with chlorpropamide therapy. (6218754)
1983
29
An active model of immune complex glomerulonephritis in the rat employing cationized antigen. (6224427)
1983
30
Experimental membranous glomerulonephritis. The relationship between circulating free antibody and immune complexes to subsequent pathology. (6214723)
1982
31
Passive immune complex glomerulonephritis in mice. III. Clearance kinetics and properties of circulating complexes. (7078095)
1982
32
The heterologous immune complex glomerulonephritis. A dose dependent glomerulonephritis with acute, latent and chronic phases in a long-term study. (6217719)
1982
33
The effect of antimacrophage antiserum on immune complex glomerulonephritis. (6454736)
1981
34
Circulating immune complexes in children with acute poststreptococcal glomerulonephritis. (7399865)
1980
35
Immune-complex glomerulonephritis associated with cytomegalovirus infection. (222131)
1979
36
Thyroid antigen associated immune complex glomerulonephritis in Graves' disease. (583094)
1979
37
Diabetes mellitus with immune complex glomerulonephritis. (377111)
1979
38
Immunity to cell surface antigens and immune complex glomerulonephritis in hamsters bearing human epithelial tumors. (153790)
1979
39
Experimental immune complex glomerulonephritis in the mouse with two types of immune complexes. (145086)
1977
40
Immune complex glomerulonephritis in a case of retroperitoneal fibrosis. (855824)
1977
41
The mesangial cell in glomerulonephritis. I. Mechanisms of hypercellularity in experimental immune complex glomerulonephritis. (140954)
1977
42
Studies of abluminuria and proteinuria in normal mice and mice with immune complex glomerulonephritis. (811741)
1975
43
Genetically controlled autologous immune complex glomerulonephritis in rats. (126258)
1975
44
Lepromatous leprosy presenting with polyarthritis, myositis, and immune-complex glomerulonephritis. (126102)
1975
45
Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. I. Production of chronic progressive immune-complex glomerulonephritis. (4275643)
1974
46
Experimental adenovirus immune complex glomerulonephritis. (4273905)
1973
47
A study of intravascular coagulation in immune complex glomerulonephritis by use of 131-I-labelled fibrinogen and 125I-labelled antigen. (4719177)
1973
48
Production of autologous immune complex glomerulonephritis in rats by injections of heterologous renal tubular antigen. (4262490)
1971
49
Naturally occurring immune-complex glomerulonephritis in the cat. (4105451)
1971
50
Autologous immune complex glomerulonephritis. 3. Studies on cellular and parabiotic transfer. (4885403)
1969

Genetic Variations for Immune-Complex Glomerulonephritis

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Expression for genes affiliated with Immune-Complex Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for genes affiliated with Immune-Complex Glomerulonephritis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Immune-Complex Glomerulonephritis

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1kininogen4410.6CFI
2pge24410.3ITGAL
3pentoxifylline44 1110.9SELP, MPO, VCAM1
4serine449.8CCR5, MPO, CCR1
5sele449.8SELP, ICAM1, VCAM1
6mannitol44 1110.8ALB, ICAM1, FTH1
7prednisolone44 28 1111.7ITGAL, MPO
8dexamethasone44 49 28 1112.6CD40LG, ITGAL, CCR1
9budesonide44 49 1111.6ICAM1, MPO, SELP, VCAM1
10polysulfone449.5VCAM1, ALB, SELP
11tetramethylpyrazine449.5ICAM1, ITGAL, SELP
12sodium cromoglycate449.5ITGAL, VCAM1, ICAM1
13fenofibrate44 49 1111.5SELP, CD40LG, VCAM1, ICAM1
14gliclazide44 49 1111.4ICAM1, MPO, ALB, VCAM1
15mycophenolic acid44 49 1111.3ALB, VCAM1, CD40LG, ICAM1
16atorvastatin44 49 28 11 2413.3VCAM1, CD40LG, SELP, ICAM1
17cuprophan449.3SELP, VCAM1, ITGAL, ICAM1
18tolmetin44 1110.3OXA1L, ALB, MPO
19slex449.3VCAM1, SELP, ITGAL, ICAM1
20rantes449.3CD40LG, CCR1, ICAM1, ITGAL
21aopp449.3MPO, OXA1L, ALB
22leukotriene b444 59 2411.3MPO, SELP, CCR1, ITGAL
23slea449.2ITGAL, SELP, CD40LG, ICAM1
24hydroxyethyl starch449.2ALB, OXA1L, SELP
25pmma449.2SELP, CD40LG, OXA1L
26pirprofen449.2OXA1L, ALB
27fluvastatin44 49 28 1112.2ITGAL, SELP, VCAM1, ICAM1
28n-formylmethionyl-leucylphenylalanine449.2SELP, MPO, ITGAL, ICAM1
29dextran sulfate449.2CCR5, ICAM1, MPO, SELP, CD40LG
30carbohydrates449.1C4B, CD40LG, CFI, VCAM1, SELP
31n acetylcysteine449.1SELP, ICAM1, MPO, CD40LG, VCAM1
32cocaine44 1110.1SELP, CCR5, VCAM1, CD40LG
33polysaccharide449.0ICAM1, CD40LG, VCAM1, SELP, CCR5
34halothane44 28 1111.0OXA1L, FTH1, SELP, ALB
35ascorbic acid44 249.9MPO, FTH1, ICAM1, ALB, CD40LG
36pravastatin44 49 28 11 2412.9ICAM1, ITGAL, VCAM1, SELP, CD40LG
37fmlp448.9ICAM1, MPO, ITGAL, SELP, VCAM1
38simvastatin44 49 59 28 11 2413.9CCR5, ICAM1, ITGAL, VCAM1, SELP
39tolmetin glucuronide448.9ALB, OXA1L
40cytochalasin d44 599.8ICAM1, ITGAL, CCR5, VCAM1
41hyaluronic acid44 249.7VCAM1, ALB, CD40LG, ITGAL, ICAM1
42lactate448.7MPO, ALB, SELP, VCAM1, CD40LG, ICAM1
43actinomycin d448.5CCR1, CCR5, CD40LG, ITGAL, ICAM1
44polyethylene glycol448.5ICAM1, MPO, ALB, CD40LG, OXA1L
45histamine44 28 2410.4MPO, CD40LG, VCAM1, ALB, CCR5, SELP
46cholesterol44 28 11 2411.4CFI, ALB, SELP, VCAM1, CCR5, ITGAL
47heparin44 28 11 2411.2CCR1, VCAM1, CFI, CD40LG, MPO, ITGAL
48retinoic acid44 248.8SELP, CCR1, VCAM1, ITGAL, CCR5, CFI
49cysteine447.4CD40LG, VCAM1, SELP, OXA1L, ITGAL, CCR1
50fibrinogen447.4CFI, CD40LG, OXA1L, ITGAL, ALB, ICAM1

GO Terms for genes affiliated with Immune-Complex Glomerulonephritis

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16Gene Ontology
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Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.6SELP, CCR5, CCR1, ICAM1, ITGAL, CD40LG
2extracellular spaceGO:0056157.6C4B, MPO, CD40LG, CFI, VCAM1, SELP

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:0024079.9CCR1, CCR5
2leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
3membrane to membrane dockingGO:0226149.8ICAM1, VCAM1
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:0022919.6ITGAL, ICAM1
5heterophilic cell-cell adhesionGO:0071579.1ICAM1, ITGAL, VCAM1, SELP
6regulation of immune responseGO:0507768.9ICAM1, ITGAL, CD40LG, VCAM1
7leukocyte migrationGO:0509008.9SELP, ITGAL, ICAM1
8leukocyte cell-cell adhesionGO:0071598.7SELP, VCAM1, CD40LG, ITGAL, ICAM1
9cell adhesionGO:0071558.7CCR1, ICAM1, ITGAL, VCAM1, SELP
10inflammatory responseGO:0069548.3CCR5, CCR1, C4B, ITGAL, CD40LG, SELP

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:0717919.9CCR1, CCR5
2chemokine receptor activityGO:0049509.9CCR1, CCR5
3C-C chemokine bindingGO:0199579.8CCR1, CCR5
4C-C chemokine receptor activityGO:0164939.6CCR1, CCR5

Products for genes affiliated with Immune-Complex Glomerulonephritis

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Sources for Immune-Complex Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet