MCID: IMM001
MIFTS: 50

Immune-Complex Glomerulonephritis malady

Immune diseases category

Summaries for Immune-Complex Glomerulonephritis

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MalaCards: Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to glomerulonephritis and membranous glomerulonephritis. An important gene associated with Immune-Complex Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are Malaria and Classical antibody-mediated complement activation. The compounds kininogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Immune-Complex Glomerulonephritis

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

immune-complex glomerulonephritis 8 60
immune complex glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:4784
SNOMED-CT56 123752003
NCIt39 C35800

Related Diseases for Immune-Complex Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9ALB, VCAM1, CFI, CD40LG, OXA1L, MPO
2membranous glomerulonephritis30.8ALB, CCR5
3proliferative glomerulonephritis30.8SELP
4proteinuria30.7MPO, CD40LG, ALB
5leukemia30.6CCR1, ICAM1, ITGAL, MPO, OXA1L, CD40LG
6vasculitis30.5ICAM1, MPO, CD40LG, CFI, VCAM1, SELP
7hepatitis30.5CD40LG
8nephrotic syndrome30.5CFI, ALB
9thrombocytopenia30.3ALB, SELP, CD40LG
10hepatitis c30.3CCR5, FTH1, CD40LG, ALB
11diabetes mellitus30.3ICAM1, OXA1L, FTH1, CD40LG, VCAM1, SELP
12crohn's disease30.1ALB
13skin disease30.1MPO, ALB
14pneumonia30.1OXA1L, MPO, ICAM1
15hepatitis b30.1ITGAL, OXA1L, ALB
16tuberculosis30.1CCR1, ITGAL, ALB
17sarcoidosis30.1CCR5, ICAM1, SELP
18diabetic nephropathy30.1CCR1, OXA1L, ALB
19graves' disease30.1CCR5, ICAM1, ITGAL, MPO, VCAM1
20connective tissue disease30.1ICAM1, MPO, CD40LG, VCAM1, ALB
21arthritis30.1CCR5, CCR1, ICAM1, MPO, FTH1, ALB
22rheumatoid arthritis30.1CCR5, CCR1, ICAM1, ITGAL, MPO, OXA1L
23aleutian mink disease10.3
24complement deficiency10.3
25amyloidosis10.3
26endocarditis10.3
27leprosy10.3
28thyroiditis10.3
29ureteral obstruction10.1
30chronic granulomatous disease10.1
31hepatitis e10.1
32mixed connective tissue disease10.1
33complement factor i deficiency10.1
34hemosiderosis10.1
35anti-basement membrane glomerulonephritis10.1
36fanconi syndrome10.1
37bone lymphoma10.1
38lepromatous leprosy10.1
39c3 deficiency10.1
40celiac disease10.1
41sialadenitis10.1
42morbid obesity10.1
43lymphosarcoma10.1
44cryptococcosis10.1
45porokeratosis10.1
46acne10.1
47diffuse glomerulonephritis10.1
48filariasis10.1
49hypothyroidism10.1
50myasthenia gravis10.1

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to immune-complex glomerulonephritis

Clinical Features for Immune-Complex Glomerulonephritis

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Drugs & Therapeutics for Immune-Complex Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Immune-Complex Glomerulonephritis

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Anatomical Context for Immune-Complex Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

32
Kidney, T cells, Bone, Bone marrow, Liver, Thyroid, Monocytes, Spleen, Myeloid, Skin

Animal Models for Immune-Complex Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4CFI, C4B
2MP:00053708.3CCR5, CCR1, C4B, FTH1, SELP, ALB
3MP:00053847.6CCR1, ICAM1, ITGAL, FTH1, CD40LG, VCAM1
4MP:00053857.5CCR5, CCR1, ICAM1, C4B, MPO, FTH1
5MP:00107687.0CCR5, CCR1, ICAM1, C4B, MPO, FTH1
6MP:00053976.9C4B, ICAM1, CCR1, CCR5, ITGAL, MPO
7MP:00053876.9C4B, ICAM1, CCR1, CCR5, ITGAL, MPO
8MP:00053766.3ALB, CCR5, CCR1, ICAM1, C4B, ITGAL

Publications for Immune-Complex Glomerulonephritis

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50PubMed
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Articles related to Immune-Complex Glomerulonephritis:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Tocilizumab-induced immune complex glomerulonephritis in a patient with rheumatoid arthritis. (23325036)
2013
2
Mechanisms of immune complex-mediated experimental glomerulonephritis: possible role of the balance between endogenous TNF and soluble TNF receptor typeA 2. (22449555)
2012
3
Immune-complex deposits in "pauci-immune" glomerulonephritis: a case report and brief review of recent literature. (22371811)
2010
4
Familial C4B deficiency and immune complex glomerulonephritis. (20580617)
2010
5
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. (19740350)
2009
6
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. (17991287)
2008
7
Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. (17544622)
2007
8
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. (15755760)
2005
9
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. (15696187)
2005
10
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis. (14675039)
2004
11
Biopsy-proven resolution of immune complex-mediated crescentic glomerulonephritis with mycophenolate mofetil therapy in an allograft. (10070920)
1999
12
Cell-to-cell interaction is required to induce proteinuria in in situ immune complex glomerulonephritis. (9708572)
1998
13
Chemokines are expressed in a myeloid cell-dependent fashion and mediate distinct functions in immune complex glomerulonephritis in rat. (9103462)
1997
14
Angiotensin-converting enzyme inhibition in experimental in-situ immune complex glomerulonephritis: influence on renal function, proteinuria, and morphology. (8649651)
1996
15
Complement synthesis in the injured kidney: does it have a role in immune complex glomerulonephritis? (8959620)
1996
16
Immune complex glomerulonephritis with unusual microfibrillar deposits associated with primary bone marrow lymphoma. (8418626)
1993
17
Development of immune-complex glomerulonephritis and amyloidosis in Syrian golden hamsters infected with Opisthorchis viverrini. (1402485)
1992
18
Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MRL lpr/lpr mice. (1394437)
1992
19
Immune complex glomerulonephritis in experimental kala-azar. II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters. (1544224)
1992
20
Experimental immune complex glomerulonephritis and the nephrotic syndrome in cats immunised with cationised bovine serum albumin. (2148430)
1990
21
Possible role of IL-6 in pathogenesis of immune complex-mediated glomerulonephritis in NZB/W F1 mice: induction of IgG class anti-DNA autoantibody production. (2086490)
1990
22
Hydroxyl radical scavengers ameliorate proteinuria in rat immune complex glomerulonephritis. (2460571)
1988
23
Effects of a specific thromboxane synthetase inhibitor on development of experimental Dirofilaria immitis immune complex glomerulonephritis in the dog. (2976425)
1988
24
The erythrocyte-immune complex-glomerulonephritis connection in man. (3295360)
1987
25
Successful immunosuppressive therapy in a patient with autoantibodies to insulin receptors and immune complex glomerulonephritis. (3603112)
1987
26
Effect of the antiplatelet agents ticlopidine and dipyridamole on experimental immune complex glomerulonephritis in rats. (2939358)
1986
27
Ultramicroscopic localization of cationized antigen in the glomerular basement membrane in the course of active, in situ immune complex glomerulonephritis. (2859686)
1985
28
Experimental immune complex glomerulonephritis in dogs receiving cationized bovine serum albumin. (3892609)
1985
29
Serial changes in humoral and cellular immunity induced by prostaglandin E2 treatment of murine immune complex glomerulonephritis. (2932513)
1985
30
Immune complex glomerulonephritis in hydralazine-induced SLE. (6229178)
1984
31
The effect of pepsin on autologous immune complex glomerulonephritis. (6224064)
1983
32
Antigen size and charge in immune complex glomerulonephritis. II. Passive induction of immune deposits with dextran-anti-dextran immune complexes. (6190406)
1983
33
Urticaria, vasculitis, hypocomplementemia, and immune-complex glomerulonephritis. (6460484)
1982
34
Involvement of the macrophage in experimental chronic immune complex glomerulonephritis. (6218416)
1982
35
Circulating immune complexes in patients with IgA glomerulonephritis. (6985242)
1982
36
Circulating immune complexes in membranoproliferative glomerulonephritis. (6801370)
1981
37
Rapidly progressive glomerulonephritis. Combined antiglomerular basement membrane antibody and immune complex pathogenesis. (7024099)
1981
38
A model of in situ immune complex glomerulonephritis in the rat employing cationized ferritin. (7014052)
1980
39
Membranous (peri-, epi-, extramembranous) glomerulonephritis. Prototype of an immune complex glomerulonephritis. A clinical morphological study. (6450491)
1980
40
Evidence that the antigen of autologous immune complex glomerulonephritis of rats is a mannose- or glucose-containing glycoprotein. (6444339)
1980
41
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
42
Experimental chronic serum sickness in rats. A model of immune complex glomerulonephritis and systemic immune complex deposition. (156700)
1979
43
Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis. (159975)
1979
44
Immune complex glomerulonephritis in chronic granulomatous disease. Case report of an eighteen-year-old girl. (495232)
1979
45
Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. (750695)
1978
46
Collagenase activity of rat kidney with immune complex glomerulonephritis. (201399)
1978
47
T-cell deficiency in immune complex glomerulonephritis. (302360)
1977
48
Fatal immune complex glomerulonephritis without deposits. (123971)
1975
49
Chronic membranous glomerulonephritis caused by hepatitis B antigen-antibody immune complexes. (4212994)
1974
50
A case of immune complex glomerulonephritis in a dog. (4557007)
1972

Genetic Variations for Immune-Complex Glomerulonephritis

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Expression for genes affiliated with Immune-Complex Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for genes affiliated with Immune-Complex Glomerulonephritis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Immune-Complex Glomerulonephritis

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1kininogen4410.6CFI
2pge24410.3ITGAL
3pentoxifylline44 1110.9SELP, MPO, VCAM1
4serine449.8CCR5, CCR1, MPO
5sele449.8SELP, ICAM1, VCAM1
6mannitol44 1110.8ALB, ICAM1, FTH1
7prednisolone44 28 1111.7ITGAL, MPO
8dexamethasone44 49 28 1112.6CD40LG, ITGAL, CCR1
9budesonide44 49 1111.6ICAM1, MPO, SELP, VCAM1
10polysulfone449.5VCAM1, ALB, SELP
11tetramethylpyrazine449.5ICAM1, ITGAL, SELP
12sodium cromoglycate449.5ITGAL, VCAM1, ICAM1
13fenofibrate44 49 1111.5SELP, CD40LG, VCAM1, ICAM1
14gliclazide44 49 1111.4ICAM1, MPO, ALB, VCAM1
15mycophenolic acid44 49 1111.3ALB, VCAM1, CD40LG, ICAM1
16atorvastatin44 49 28 11 2413.3VCAM1, CD40LG, SELP, ICAM1
17cuprophan449.3SELP, VCAM1, ITGAL, ICAM1
18tolmetin44 1110.3OXA1L, ALB, MPO
19slex449.3VCAM1, SELP, ITGAL, ICAM1
20rantes449.3CD40LG, CCR1, ICAM1, ITGAL
21aopp449.3MPO, OXA1L, ALB
22leukotriene b444 59 2411.3CCR1, ITGAL, MPO, SELP
23slea449.2ITGAL, SELP, CD40LG, ICAM1
24hydroxyethyl starch449.2ALB, OXA1L, SELP
25pmma449.2SELP, CD40LG, OXA1L
26azapropazone44 1110.2OXA1L, ALB
27fluvastatin44 49 28 1112.2ITGAL, SELP, VCAM1, ICAM1
28n-formylmethionyl-leucylphenylalanine449.2SELP, MPO, ITGAL, ICAM1
29dextran sulfate449.2CCR5, ICAM1, MPO, SELP, CD40LG
30carbohydrates449.1C4B, CD40LG, CFI, VCAM1, SELP
31n acetylcysteine449.1SELP, ICAM1, MPO, CD40LG, VCAM1
32cocaine44 1110.1VCAM1, SELP, CD40LG, CCR5
33polysaccharide449.0ICAM1, CD40LG, VCAM1, SELP, CCR5
34halothane44 28 1111.0OXA1L, FTH1, SELP, ALB
35ascorbic acid44 249.9FTH1, ICAM1, MPO, CD40LG, ALB
36pravastatin44 49 28 11 2412.9ICAM1, ITGAL, VCAM1, SELP, CD40LG
37fmlp448.9ICAM1, MPO, ITGAL, SELP, VCAM1
38simvastatin44 49 59 28 11 2413.9CCR5, ICAM1, ITGAL, VCAM1, SELP
39kebuzone448.9OXA1L, ALB
40cytochalasin d44 599.8ICAM1, CCR5, VCAM1, ITGAL
41hyaluronic acid44 249.7VCAM1, ALB, CD40LG, ITGAL, ICAM1
42lactate448.7MPO, ALB, SELP, VCAM1, CD40LG, ICAM1
43actinomycin d448.5CCR1, CCR5, CD40LG, ICAM1, ITGAL
44polyethylene glycol448.5ICAM1, MPO, ALB, CD40LG, OXA1L
45histamine44 28 2410.4MPO, CD40LG, VCAM1, ALB, CCR5, SELP
46cholesterol44 28 11 2411.4ITGAL, ALB, SELP, VCAM1, CCR5, CFI
47heparin44 28 11 2411.2CCR1, VCAM1, CFI, CD40LG, MPO, ITGAL
48retinoic acid44 248.8SELP, CCR1, VCAM1, ITGAL, CCR5, CFI
49cysteine447.4CD40LG, VCAM1, SELP, OXA1L, ITGAL, CCR1
50fibrinogen447.4CFI, CD40LG, OXA1L, ITGAL, ALB, ICAM1

GO Terms for genes affiliated with Immune-Complex Glomerulonephritis

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16Gene Ontology
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Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.6SELP, CCR5, CCR1, ICAM1, ITGAL, CD40LG
2extracellular spaceGO:0056157.6C4B, MPO, CD40LG, CFI, VCAM1, SELP

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:0024079.9CCR1, CCR5
2leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
3membrane to membrane dockingGO:0226149.8ICAM1, VCAM1
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:0022919.6ITGAL, ICAM1
5heterophilic cell-cell adhesionGO:0071579.1ICAM1, ITGAL, VCAM1, SELP
6regulation of immune responseGO:0507768.9ICAM1, ITGAL, CD40LG, VCAM1
7leukocyte migrationGO:0509008.9SELP, ITGAL, ICAM1
8leukocyte cell-cell adhesionGO:0071598.7SELP, VCAM1, CD40LG, ITGAL, ICAM1
9cell adhesionGO:0071558.7CCR1, ICAM1, ITGAL, VCAM1, SELP
10inflammatory responseGO:0069548.3CCR5, CCR1, C4B, ITGAL, CD40LG, SELP

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:0717919.9CCR1, CCR5
2chemokine receptor activityGO:0049509.9CCR1, CCR5
3C-C chemokine bindingGO:0199579.8CCR1, CCR5
4C-C chemokine receptor activityGO:0164939.6CCR1, CCR5

Products for genes affiliated with Immune-Complex Glomerulonephritis

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Sources for Immune-Complex Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet