MCID: IMM001
MIFTS: 41

Immune-Complex Glomerulonephritis

Categories: Nephrological diseases, Immune diseases

Aliases & Classifications for Immune-Complex Glomerulonephritis

MalaCards integrated aliases for Immune-Complex Glomerulonephritis:

Name: Immune-Complex Glomerulonephritis 12 14 69
Immune Complex Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4784
NCIt 47 C35800
SNOMED-CT 64 123752003
UMLS 69 C0744421

Summaries for Immune-Complex Glomerulonephritis

MalaCards based summary : Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to glomerulonephritis and vulvar disease. An important gene associated with Immune-Complex Glomerulonephritis is SELP (Selectin P), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Hydroxychloroquine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and t cells, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Immune-Complex Glomerulonephritis

Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 glomerulonephritis 10.9
2 vulvar disease 10.4 MPO SELP
3 scleredema adultorum 10.3 SELP VCAM1
4 focal embolic glomerulonephritis 10.2 ICAM1 MPO
5 uveitis 10.2 ICAM1 MPO
6 lymphomatous thyroiditis 10.2 ICAM1 VCAM1
7 heart lymphoma 10.2 ICAM1 VCAM1
8 marginal corneal ulcer 10.2 ICAM1 VCAM1
9 inferolateral myocardial infarct 10.2 ICAM1 VCAM1
10 moved to 244450 10.1 ICAM1 VCAM1
11 louping ill 10.1 ICAM1 MPO
12 riboflavin transporter deficiency 10.1 ICAM1 VCAM1
13 focal dystonia 10.1 SELP VCAM1
14 liver disease 10.1 ICAM1 VCAM1
15 craniopharyngioma 10.1 ICAM1 VCAM1
16 dysphagia 10.1 ICAM1 VCAM1
17 vasculitis 10.0
18 renal tubular acidosis 10.0 CCR5 ICAM1
19 dentin dysplasia 10.0 ICAM1 VCAM1
20 leukemia 10.0
21 spastic paraplegia 8 10.0 SELP VCAM1
22 proximal symphalangism 10.0 ICAM1 VCAM1
23 turner syndrome 9.9 CCR5 TLR9
24 subacute leukemia 9.9 ICAM1 MPO SELP
25 hepatitis 9.9
26 endocarditis 9.9
27 nephrotic syndrome 9.9
28 proliferative glomerulonephritis 9.9
29 retroperitoneal fibrosis 9.9
30 dermatomycosis 9.9 C4B ICAM1 MPO
31 gonococcal endophthalmia 9.9 CCR5 TLR9
32 uterine corpus sarcoma 9.9 ICAM1 SELP VCAM1
33 oppositional defiant disorder 9.9 ICAM1 SELP VCAM1
34 psychosexual disorder 9.9 ICAM1 SELP VCAM1
35 neuroaxonal dystrophy 9.9 ICAM1 TLR9
36 intra-abdominal lymph node mast cell malignancy 9.9 ICAM1 SELP VCAM1
37 myelophthisic anemia 9.9 ICAM1 SELP VCAM1
38 acute vascular insufficiency of intestine 9.9 ICAM1 TLR9
39 malignant type ab thymoma 9.9 ICAM1 SELP VCAM1
40 orbital melanoma 9.9 CCR5 ICAM1 VCAM1
41 leprosy 9.8
42 thrombocytopenia 9.8
43 hepatitis c 9.8
44 thyroiditis 9.8
45 amyloidosis 9.8
46 central nervous system leiomyosarcoma 9.8 MPO TLR9
47 peripheral artery disease 9.8 ICAM1 SELP VCAM1
48 eyelid neoplasm 9.8 ICAM1 TLR9
49 neuropathy, hereditary sensory and autonomic, type vi 9.8 ICAM1 VCAM1
50 heart sarcoma 9.8 CCR5 TLR9

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to Immune-Complex Glomerulonephritis

Symptoms & Phenotypes for Immune-Complex Glomerulonephritis

MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 FTH1 ICAM1 MPO SELP VCAM1 C4B
2 hematopoietic system MP:0005397 9.97 C4B CCR1 CCR5 FTH1 ICAM1 MPO
3 cellular MP:0005384 9.95 TLR9 VCAM1 CCR1 CCR5 FTH1 ICAM1
4 homeostasis/metabolism MP:0005376 9.91 C4B CCR1 CCR5 FTH1 ICAM1 MPO
5 immune system MP:0005387 9.81 C4B CCR1 CCR5 FTH1 ICAM1 MPO
6 digestive/alimentary MP:0005381 9.77 C4B CCR1 CCR5 ICAM1 TLR9
7 liver/biliary system MP:0005370 9.35 C4B CCR1 CCR5 FTH1 SELP
8 mortality/aging MP:0010768 9.28 C4B CCR1 CCR5 FTH1 ICAM1 MPO

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Drugs for Immune-Complex Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved Phase 4 118-42-3 3652
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6 Immunoglobulin A Phase 4
7 Anti-Infective Agents Phase 4
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Antirheumatic Agents Phase 4
12 Antiemetics Phase 4
13 Antifungal Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Autonomic Agents Phase 4
17 Calcineurin Inhibitors Phase 4
18 Cyclosporins Phase 4
19 Dermatologic Agents Phase 4
20 Gastrointestinal Agents Phase 4
21 glucocorticoids Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 Immunosuppressive Agents Phase 4
26 Methylprednisolone acetate Phase 4
27 Methylprednisolone Hemisuccinate Phase 4
28 Neuroprotective Agents Phase 4
29 Peripheral Nervous System Agents Phase 4
30 Prednisolone acetate Phase 4
31 Prednisolone hemisuccinate Phase 4
32 Prednisolone phosphate Phase 4
33 Protective Agents Phase 4
34 Antigen-Antibody Complex Phase 2
35
Captopril Approved 62571-86-2 44093
36
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
37
Losartan Approved 114798-26-4 3961
38
Angiotensin II Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
39 Complement System Proteins
40 Antibodies
41 Autoantibodies
42 Immunoglobulins
43 Adrenocorticotropic Hormone
44 Angiotensin-Converting Enzyme Inhibitors
45 Angiotensinogen
46 Anti-Arrhythmia Agents
47 beta-endorphin
48 Cardiac Glycosides
49 Endorphins
50 HIV Protease Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Controlled Study Completed NCT02351752 Phase 4 Hydroxychloroquine Sulfate
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
4 Diet Intervention in Food Sensitive Patients With IgA Nephropathy Unknown status NCT01203007
5 Probiotics in IgA Nephropathy Unknown status NCT01781312
6 Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis Completed NCT00004305
7 Prediction of Outcome of Lupus Nephritis Recruiting NCT02403115
8 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Enrolling by invitation NCT02878018 Qi ji shen kang lotion;Zhubai lotion;More Kidney lotion;Angiotensin-converting enzyme inhibitor orangiotensin II receptor blocker ;Tripterygium Glycosides;Adrenocorticotropic hormone ;Other Immunosuppressant

Search NIH Clinical Center for Immune-Complex Glomerulonephritis

Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

39
Kidney, Neutrophil, T Cells, Bone, Bone Marrow, Monocytes, Thyroid

Publications for Immune-Complex Glomerulonephritis

Articles related to Immune-Complex Glomerulonephritis:

(show top 50) (show all 249)
id Title Authors Year
1
Panitumumab-Induced Immune Complex Glomerulonephritis. ( 27765383 )
2017
2
Severe acute kidney injury in children owing to infective endocarditis-associated immune complex glomerulonephritis: a report of two cases. ( 27077635 )
2016
3
Vanillic Acid Ameliorates Cationic Bovine Serum Albumin Induced Immune Complex Glomerulonephritis in BALB/c Mice. ( 27130149 )
2016
4
CD11b is protective in complement-mediated immune complex glomerulonephritis. ( 25565310 )
2015
5
Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis. ( 26290761 )
2015
6
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. ( 26166765 )
2015
7
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. ( 26043977 )
2015
8
Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. ( 26245687 )
2015
9
The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. ( 24805106 )
2014
10
Tocilizumab-induced immune complex glomerulonephritis in a patient with rheumatoid arthritis. ( 23325036 )
2013
11
Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. ( 23481367 )
2013
12
The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. ( 22832515 )
2012
13
Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis. ( 23207123 )
2012
14
Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. ( 23064186 )
2012
15
HIV-associated immune complex glomerulonephritis with "lupus-like" features. ( 21743226 )
2011
16
Familial C4B deficiency and immune complex glomerulonephritis. ( 20580617 )
2010
17
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. ( 19740350 )
2009
18
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. ( 19158348 )
2009
19
An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). ( 18752546 )
2008
20
Immune complex glomerulonephritis following bone marrow transplantation in C3 deficient mice. ( 18836527 )
2008
21
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. ( 17991287 )
2008
22
Cryoglobulinaemia type III with severe neuropathy and immune complex glomerulonephritis: remission after plasmapheresis and rituximab. ( 17924113 )
2008
23
Mesangial immune complex glomerulonephritis due to complement factor D deficiency. ( 17410102 )
2007
24
Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis. ( 17464766 )
2007
25
Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. ( 17544622 )
2007
26
Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. ( 17259999 )
2007
27
IgM-immune complex glomerulonephritis associated with sarcoidosis. ( 16544180 )
2006
28
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis. ( 16526313 )
2006
29
Toll-like receptor-7 modulates immune complex glomerulonephritis. ( 16280469 )
2006
30
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. ( 16954173 )
2006
31
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. ( 16920982 )
2006
32
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. ( 15755760 )
2005
33
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. ( 15780090 )
2005
34
Treatment of experimental immune complex glomerulonephritis by sodium alginate. ( 15893960 )
2005
35
The role of complement in cryoglobulin-induced immune complex glomerulonephritis. ( 16272350 )
2005
36
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. ( 15696187 )
2005
37
C3 is central to the interstitial component of experimental immune complex glomerulonephritis. ( 15870025 )
2005
38
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. ( 16138437 )
2005
39
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis. ( 14675039 )
2004
40
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. ( 12538732 )
2003
41
C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. ( 12296852 )
2002
42
Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. ( 11316850 )
2001
43
Retroperitoneal fibrosis and immune-complex glomerulonephritis. ( 11393386 )
2001
44
Novel therapeutic approach by culture filtrate of Cryptococcus neoformans var. gattii (CneF) in experimental immune complex glomerulonephritis. ( 11368886 )
2000
45
Immune complex glomerulonephritis in patients with hepatitis C. ( 18209331 )
2000
46
Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. ( 10072261 )
1999
47
Juxtaglomerular cell tumor with retroperitoneal fibrosis and secondary immune-complex glomerulonephritis: a possible contribution of the renin angiotensin system to renal fibrosis. ( 10471754 )
1999
48
A syndrome of immune complex glomerulonephritis and ophthalmic abnormalities. ( 10465118 )
1999
49
Cell-to-cell interaction is required to induce proteinuria in in situ immune complex glomerulonephritis. ( 9708572 )
1998
50
Immune complex glomerulonephritis in C4- and C3-deficient mice. ( 9461092 )
1998

Variations for Immune-Complex Glomerulonephritis

Expression for Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for Immune-Complex Glomerulonephritis

GO Terms for Immune-Complex Glomerulonephritis

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 C4B ICAM1 MPO SELP TLR9 VCAM1
2 external side of plasma membrane GO:0009897 9.02 CCR1 CCR5 ICAM1 SELP VCAM1

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.76 CCR1 ICAM1 SELP VCAM1
2 response to ionizing radiation GO:0010212 9.48 ICAM1 VCAM1
3 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELP VCAM1
4 calcium-mediated signaling using intracellular calcium source GO:0035584 9.43 SELP VCAM1
5 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELP VCAM1
6 dendritic cell chemotaxis GO:0002407 9.4 CCR1 CCR5
7 leukocyte tethering or rolling GO:0050901 9.37 SELP VCAM1
8 inflammatory response GO:0006954 9.35 C4B CCR1 CCR5 SELP TLR9
9 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
10 leukocyte cell-cell adhesion GO:0007159 8.8 ICAM1 SELP VCAM1

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.32 CCR1 CCR5
2 chemokine receptor activity GO:0004950 9.26 CCR1 CCR5
3 C-C chemokine receptor activity GO:0016493 9.16 CCR1 CCR5
4 C-C chemokine binding GO:0019957 8.96 CCR1 CCR5
5 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR1 CCR5

Sources for Immune-Complex Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....