MCID: IMM001
MIFTS: 39

Immune-Complex Glomerulonephritis

Categories: Immune diseases, Nephrological diseases

Aliases & Classifications for Immune-Complex Glomerulonephritis

MalaCards integrated aliases for Immune-Complex Glomerulonephritis:

Name: Immune-Complex Glomerulonephritis 12 14 69
Immune Complex Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4784
NCIt 46 C35800
SNOMED-CT 64 123752003
UMLS 69 C0744421

Summaries for Immune-Complex Glomerulonephritis

MalaCards based summary : Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to vasculitis and complement factor i deficiency. An important gene associated with Immune-Complex Glomerulonephritis is SELP (Selectin P), and among its related pathways/superpathways are Innate Immune System and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. Affiliated tissues include kidney, neutrophil and t cells, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Immune-Complex Glomerulonephritis

Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.0 ICAM1 MPO VCAM1
2 complement factor i deficiency 29.9 C4B CFI
3 cytomegalovirus infection 29.7 ICAM1 VCAM1
4 glomerulonephritis 29.3 C4B CFI ICAM1 MPO TLR9 VCAM1
5 maxillary sinusitis 10.3 MPO SELP
6 rapidly progressive glomerulonephritis 10.3 ICAM1 MPO
7 acute proliferative glomerulonephritis 10.3 ICAM1 MPO
8 multiple symmetrical lipomatosis 10.2 SELP VCAM1
9 pleurisy 10.2 ICAM1 MPO
10 lymphocytic vasculitis 10.2 ICAM1 VCAM1
11 cortical thymoma 10.1 ICAM1 VCAM1
12 mooren's ulcer 10.1 ICAM1 VCAM1
13 subendocardial myocardial infarction 10.1 ICAM1 VCAM1
14 actinic prurigo 10.1 ICAM1 VCAM1
15 rheumatoid vasculitis 10.1 ICAM1 VCAM1
16 limbal stem cell deficiency 10.1 ICAM1 VCAM1
17 leukemia 10.1
18 shwartzman phenomenon 10.1 ICAM1 VCAM1
19 ischemia 10.0 ICAM1 MPO SELP
20 fibrosis of extraocular muscles, congenital, 1 10.0
21 hepatitis 10.0
22 endocarditis 10.0
23 nephrotic syndrome 10.0
24 proliferative glomerulonephritis 10.0
25 retroperitoneal fibrosis 10.0
26 hypersensitivity reaction type iii disease 10.0 C4B ICAM1 MPO
27 dengue disease 10.0 ICAM1 VCAM1
28 peripheral artery disease 10.0 SELP VCAM1
29 arteriosclerosis obliterans 10.0 ICAM1 SELP VCAM1
30 chronic venous insufficiency 10.0 ICAM1 SELP VCAM1
31 venous insufficiency 9.9 ICAM1 SELP VCAM1
32 atherosclerosis susceptibility 9.9 ICAM1 SELP VCAM1
33 arteriosclerosis 9.9 ICAM1 SELP VCAM1
34 cerebrovascular disease 9.9 ICAM1 SELP VCAM1
35 post-thrombotic syndrome 9.9 ICAM1 TLR9
36 blood group, i system 9.9
37 leprosy 3 9.9
38 meester-loeys syndrome 9.9
39 diabetes mellitus 9.9
40 thrombocytopenia 9.9
41 hepatitis c 9.9
42 thyroiditis 9.9
43 amyloidosis 9.9
44 oral lichen planus 9.9 CCR5 ICAM1 VCAM1
45 yellow fever 9.9 CCR5 TLR9
46 lichen disease 9.9 ICAM1 TLR9
47 primary progressive multiple sclerosis 9.9 ICAM1 VCAM1
48 henoch-schoenlein purpura 9.9 ICAM1 MPO VCAM1
49 leukostasis 9.9 ICAM1 MPO VCAM1
50 ileitis 9.8 MPO TLR9

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to Immune-Complex Glomerulonephritis

Symptoms & Phenotypes for Immune-Complex Glomerulonephritis

MGI Mouse Phenotypes related to Immune-Complex Glomerulonephritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CFI TLR9 FTH1 C4B ICAM1 CCR1
2 cardiovascular system MP:0005385 10.06 FTH1 C4B ICAM1 CCR1 MPO CCR5
3 homeostasis/metabolism MP:0005376 10.02 CFI FTH1 C4B ICAM1 CCR1 MPO
4 cellular MP:0005384 9.98 SELP FTH1 ICAM1 CCR1 CCR5 TLR9
5 immune system MP:0005387 9.91 FTH1 C4B ICAM1 CCR1 MPO CCR5
6 digestive/alimentary MP:0005381 9.8 C4B ICAM1 CCR1 CCR5 TLR9
7 mortality/aging MP:0010768 9.61 FTH1 C4B ICAM1 CCR1 MPO CCR5
8 liver/biliary system MP:0005370 9.55 FTH1 C4B CCR1 CCR5 SELP
9 renal/urinary system MP:0005367 9.02 SELP CFI C4B CCR1 TLR9

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Search Clinical Trials , NIH Clinical Center for Immune-Complex Glomerulonephritis

Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

38
Kidney, Neutrophil, T Cells, Bone, Bone Marrow, Monocytes, Thyroid

Publications for Immune-Complex Glomerulonephritis

Articles related to Immune-Complex Glomerulonephritis:

(show top 50) (show all 251)
# Title Authors Year
1
The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis. ( 29395335 )
2018
2
Panitumumab-Induced Immune Complex Glomerulonephritis. ( 27765383 )
2017
3
The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis. ( 29025319 )
2017
4
Vanillic Acid Ameliorates Cationic Bovine Serum Albumin Induced Immune Complex Glomerulonephritis in BALB/c Mice. ( 27130149 )
2016
5
Severe acute kidney injury in children owing to infective endocarditis-associated immune complex glomerulonephritis: a report of two cases. ( 27077635 )
2016
6
Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis. ( 26290761 )
2015
7
Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. ( 26043977 )
2015
8
CD11b is protective in complement-mediated immune complex glomerulonephritis. ( 25565310 )
2015
9
Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. ( 26245687 )
2015
10
Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. ( 26166765 )
2015
11
The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. ( 24805106 )
2014
12
Tocilizumab-induced immune complex glomerulonephritis in a patient with rheumatoid arthritis. ( 23325036 )
2013
13
Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. ( 23481367 )
2013
14
The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. ( 22832515 )
2012
15
Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. ( 23064186 )
2012
16
Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis. ( 23207123 )
2012
17
HIV-associated immune complex glomerulonephritis with "lupus-like" features. ( 21743226 )
2011
18
Familial C4B deficiency and immune complex glomerulonephritis. ( 20580617 )
2010
19
Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis. ( 19740350 )
2009
20
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. ( 19158348 )
2009
21
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. ( 17991287 )
2008
22
Immune complex glomerulonephritis following bone marrow transplantation in C3 deficient mice. ( 18836527 )
2008
23
Cryoglobulinaemia type III with severe neuropathy and immune complex glomerulonephritis: remission after plasmapheresis and rituximab. ( 17924113 )
2008
24
An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). ( 18752546 )
2008
25
Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis. ( 17544622 )
2007
26
Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis. ( 17464766 )
2007
27
Mesangial immune complex glomerulonephritis due to complement factor D deficiency. ( 17410102 )
2007
28
Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. ( 17259999 )
2007
29
IgM-immune complex glomerulonephritis associated with sarcoidosis. ( 16544180 )
2006
30
CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. ( 16920982 )
2006
31
Toll-like receptor-7 modulates immune complex glomerulonephritis. ( 16280469 )
2006
32
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. ( 16954173 )
2006
33
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis. ( 16526313 )
2006
34
Treatment of experimental immune complex glomerulonephritis by sodium alginate. ( 15893960 )
2005
35
The role of complement in cryoglobulin-induced immune complex glomerulonephritis. ( 16272350 )
2005
36
C3 is central to the interstitial component of experimental immune complex glomerulonephritis. ( 15870025 )
2005
37
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. ( 16138437 )
2005
38
Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury. ( 15696187 )
2005
39
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. ( 15780090 )
2005
40
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. ( 15755760 )
2005
41
Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis. ( 14675039 )
2004
42
Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. ( 12538732 )
2003
43
C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. ( 12296852 )
2002
44
Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. ( 11316850 )
2001
45
Retroperitoneal fibrosis and immune-complex glomerulonephritis. ( 11393386 )
2001
46
Novel therapeutic approach by culture filtrate of Cryptococcus neoformans var. gattii (CneF) in experimental immune complex glomerulonephritis. ( 11368886 )
2000
47
Immune complex glomerulonephritis in patients with hepatitis C. ( 18209331 )
2000
48
A syndrome of immune complex glomerulonephritis and ophthalmic abnormalities. ( 10465118 )
1999
49
Juxtaglomerular cell tumor with retroperitoneal fibrosis and secondary immune-complex glomerulonephritis: a possible contribution of the renin angiotensin system to renal fibrosis. ( 10471754 )
1999
50
Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. ( 10072261 )
1999

Variations for Immune-Complex Glomerulonephritis

Expression for Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for Immune-Complex Glomerulonephritis

GO Terms for Immune-Complex Glomerulonephritis

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C4B CFI ICAM1 MPO SELP TLR9
2 external side of plasma membrane GO:0009897 9.02 CCR1 CCR5 ICAM1 SELP VCAM1

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.76 CCR1 ICAM1 SELP VCAM1
2 response to lipopolysaccharide GO:0032496 9.46 ICAM1 MPO SELP VCAM1
3 calcium-mediated signaling using intracellular calcium source GO:0035584 9.43 SELP VCAM1
4 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELP VCAM1
5 dendritic cell chemotaxis GO:0002407 9.4 CCR1 CCR5
6 leukocyte tethering or rolling GO:0050901 9.37 SELP VCAM1
7 inflammatory response GO:0006954 9.35 C4B CCR1 CCR5 SELP TLR9
8 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
9 leukocyte cell-cell adhesion GO:0007159 8.8 ICAM1 SELP VCAM1

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phospholipase C activity GO:0004435 9.32 CCR1 CCR5
2 chemokine receptor activity GO:0004950 9.26 CCR1 CCR5
3 C-C chemokine receptor activity GO:0016493 9.16 CCR1 CCR5
4 C-C chemokine binding GO:0019957 8.96 CCR1 CCR5
5 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR1 CCR5

Sources for Immune-Complex Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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