MCID: IMM001
MIFTS: 47

Immune-Complex Glomerulonephritis malady

Immune category

Summaries for Immune-Complex Glomerulonephritis

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33MalaCards
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MalaCards: Immune-Complex Glomerulonephritis, also known as immune complex glomerulonephritis, is related to proliferative glomerulonephritis and vasculitis. An important gene associated with Immune-Complex Glomerulonephritis is CCR1 (chemokine (C-C motif) receptor 1), and among its related pathways are Malaria and Classical antibody-mediated complement activation. The compounds kininogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Immune-Complex Glomerulonephritis

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

immune-complex glomerulonephritis 8 61
immune complex glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:4784
SNOMED-CT57 123752003
NCIt40 C35800

Related Diseases for Immune-Complex Glomerulonephritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Immune-Complex Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative glomerulonephritis30.8SELP
2vasculitis30.6ICAM1, MPO, CD40LG, CFI, VCAM1, SELP
3hepatitis c30.5CCR5, FTH1, CD40LG, ALB
4thrombocytopenia30.4ALB, SELP, CD40LG
5membranous glomerulonephritis30.4ALB, CCR5
6nephritis30.4ALB, VCAM1, CFI, CD40LG, MPO
7goodpasture syndrome30.2MPO, VCAM1
8tuberculosis30.2CCR1, ITGAL, ALB
9diabetic nephropathy30.1CCR1, OXA1L, ALB
10graves' disease30.1CCR5, ICAM1, ITGAL, MPO, VCAM1
11arthritis30.1CCR5, CCR1, ICAM1, MPO, FTH1, ALB
12aleutian mink disease10.4
13anti-basement membrane glomerulonephritis10.4
14n syndrome10.4
15retroperitoneal fibrosis10.4
16complement factor i deficiency10.3
17amyloidosis10.3
18complement factor d deficiency10.3
19ureteral obstruction10.1
20chronic granulomatous disease10.1
21mixed connective tissue disease10.1
22hemosiderosis10.1
23good syndrome10.1
24factor v deficiency10.1
25fanconi syndrome10.1
26bone lymphoma10.1
27lepromatous leprosy10.1
28celiac disease10.1
29sialadenitis10.1
30hepatitis d10.1
31morbid obesity10.1
32lymphosarcoma10.1
33cryptococcosis10.1
34porokeratosis10.1
35hepatitis a10.1
36acne10.1
37urticaria10.1
38klebsiella10.1
39cytomegalovirus infection10.1
40bacteremia10.1
41hepatitis c virus10.1
42primary bone lymphoma10.1
43endometriosis10.0CCR1
44hemolytic-uremic syndrome10.0CFI
45mycosis fungoides10.0ITGAL
46fatty liver disease10.0FTH1
47viral hepatitis10.0ITGAL
48thromboembolism10.0SELP
49cholera10.0OXA1L
50cerebrovascular disease10.0SELP

Graphical network of the top 20 diseases related to Immune-Complex Glomerulonephritis:



Diseases related to immune-complex glomerulonephritis

Clinical Features for Immune-Complex Glomerulonephritis

Drugs & Therapeutics for Immune-Complex Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Immune-Complex Glomerulonephritis

Anatomical Context for Immune-Complex Glomerulonephritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Immune-Complex Glomerulonephritis:

33
Skin, Liver, Kidney, Spleen, Bone marrow, Thyroid, Myeloid, Monocytes, T cells, B cells

Animal Models for Immune-Complex Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Immune-Complex Glomerulonephritis

Sources:
51PubMed
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Articles related to Immune-Complex Glomerulonephritis:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis. (23788594)
2013
2
Immune-complex deposits in pANCA glomerulonephritis: a pediatric case report. (23771091)
2013
3
Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis. (23320965)
2013
4
Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. (20702729)
2010
5
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. (19158348)
2009
6
Cryoglobulinaemia type III with severe neuropathy and immune complex glomerulonephritis: remission after plasmapheresis and rituximab. (17924113)
2008
7
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. (16954173)
2006
8
C3 is central to the interstitial component of experimental immune complex glomerulonephritis. (15870025)
2005
9
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. (16138437)
2005
10
Treatment of experimental immune complex glomerulonephritis by sodium alginate. (15893960)
2005
11
Demonstration of apoptosis-associated cleavage products of DNA, complement activation products SC5b-9 and C3d/dg, and immune complexes CIC-C3d, CIC-IgA, and CIC-IgG in the urine of patients with membranous glomerulonephritis. (14652883)
2003
12
Juxtaglomerular cell tumor with retroperitoneal fibrosis and secondary immune-complex glomerulonephritis: a possible contribution of the renin angiotensin system to renal fibrosis. (10471754)
1999
13
Glomerular handling of immune complex in the acute phase of active in situ immune complex glomerulonephritis employing cationized ferritin in rats. Ultrastructural localization of immune complex, complements and inflammatory cells. (9247633)
1997
14
Clinical and pathophysiological aspects of immune complex glomerulonephritis associated with Entamoeba histolytica abscess of the liver. (9332542)
1997
15
Cloning of the mouse fibronectin V-region and variation of its splicing pattern in experimental immune complex glomerulonephritis. (8691328)
1996
16
Pulmonary hemosiderosis and immune complex glomerulonephritis. (7634551)
1995
17
Do mesangial immune complex deposits affect the renal prognosis in membranous glomerulonephritis? (8050206)
1994
18
Immune-complex glomerulonephritis--deposits plus interest. (8421481)
1993
19
Glomerulonephritis with organized deposits: a mesangiopathic, not immune complex-mediated disease? A pathologic study of two cases in the same family. (1544672)
1992
20
Autologous immune complex glomerulonephritis induces abnormal embryonic development. (2187088)
1990
21
Mononuclear cells in glomeruli and cytokines in urine reflect the severity of experimental proliferative immune complex glomerulonephritis. (2141559)
1990
22
The role of cationic proteins in the pathogenesis of immune complex glomerulonephritis. (2151742)
1990
23
Glomerular epithelial-cell endocytosis of horseradish peroxidase-polylysine conjugate in immune-complex glomerulonephritis. (2151704)
1990
24
Studies on circulating immune complexes. II: Circulating immune complexes in primary IgA nephropathy and membranoproliferative glomerulonephritis. (2739118)
1989
25
IgE and immune complex glomerulonephritis. (2965544)
1988
26
Active in situ immune complex glomerulonephritis using the hapten-carrier system: role of epitope density in cationic antigens. (2464447)
1988
27
Experimental immune complex glomerulonephritis: immunofluorescent, light and electron microscopic study. (3520000)
1986
28
Weber-Christian panniculitis with immune complex glomerulonephritis. (3157006)
1985
29
Failure to detect murine leukemia virus antigens in immune-complex glomerulonephritis of graft-vs-host F1 mice. (3009932)
1985
30
Alterations in serum antibody and peripheral T-lymphocyte subsets resulting from treatment of murine immune complex glomerulonephritis with PGE2. (3871180)
1985
31
Serum immunoglobulin sedimentation patterns and circulating immune complexes in IgA glomerulonephritis and SchAPnlein-Henoch nephritis. (6377828)
1984
32
Preservation of fixed anionic sites in the GBM in the acute proteinuric phase of cationic antigen mediated in-situ immune complex glomerulonephritis in the rat. (6238922)
1984
33
Impairment of glomerular clearance of macroaggregates in immune complex glomerulonephritis. (6214656)
1982
34
Ultrafiltration coefficient and glomerular capillary resistance a model of immune complex glomerulonephritis. (7077945)
1982
35
Role of antigen size and charge in immune complex glomerulonephritis. (6180247)
1982
36
The heterologous immune complex glomerulonephritis. A dose dependent glomerulonephritis with acute, latent and chronic phases in a long-term study. (6217719)
1982
37
Immune complex glomerulonephritis in baboons (Papio cynocephalus) with indwelling intravascular catheters. (6458737)
1981
38
Immune-complex glomerulonephritis secondary to nonspecific immunotherapy. (6444365)
1980
39
Immune complex glomerulonephritis in mice infected with Escherichia coli. (6450654)
1980
40
Immune complex glomerulonephritis of mink with Aleutian disease. (6445810)
1980
41
Immune complex glomerulonephritis in leprosy. (522599)
1979
42
Immunity to cell surface antigens and immune complex glomerulonephritis in hamsters bearing human epithelial tumors. (153790)
1979
43
Cryoglobulins in acute experimental immune complex glomerulonephritis. (150453)
1978
44
HBsAg immune complex glomerulonephritis. (368789)
1978
45
Thyroglobulin-anti-thyroglobulin immune complex glomerulonephritis complicating radioiodine therapy. (342161)
1978
46
The influence of selective thrombocytopenia on immune complex glomerulonephritis. (152343)
1978
47
Immune complex glomerulonephritis mediated by thyroid antigens. (152097)
1978
48
Immune complex glomerulonephritis associated with Klebsiella pneumoniae infection. (321171)
1977
49
Immune complex glomerulonephritis in one-year-old C57BL-6 mice induced by endogenous murine leukemia virus and erythrocyte antigens. (4356323)
1973
50
Pathogenesis of immune complex glomerulonephritis of new zealand mice. (19867382)
1971

Genetic Variations for Immune-Complex Glomerulonephritis

Expression for genes affiliated with Immune-Complex Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Immune-Complex Glomerulonephritis

Search GEO for disease gene expression data for Immune-Complex Glomerulonephritis.

Pathways for genes affiliated with Immune-Complex Glomerulonephritis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Immune-Complex Glomerulonephritis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1kininogen4510.6CFI
2pge24510.3ITGAL
3pentoxifylline45 1110.9MPO, VCAM1, SELP
4serine459.8CCR5, CCR1, MPO
5sele459.8SELP, VCAM1, ICAM1
6mannitol45 1110.8ALB, FTH1, ICAM1
7prednisolone45 29 1111.7ITGAL, MPO
8dexamethasone45 50 29 1112.6CD40LG, ITGAL, CCR1
9budesonide45 50 1111.6ICAM1, MPO, VCAM1, SELP
10polysulfone459.5ALB, SELP, VCAM1
11tetramethylpyrazine459.5ICAM1, ITGAL, SELP
12sodium cromoglycate459.5VCAM1, ITGAL, ICAM1
13fenofibrate45 50 1111.5SELP, VCAM1, CD40LG, ICAM1
14gliclazide45 50 1111.4ICAM1, MPO, VCAM1, ALB
15mycophenolic acid45 50 1111.3ALB, VCAM1, CD40LG, ICAM1
16atorvastatin45 50 29 11 2413.3ICAM1, CD40LG, VCAM1, SELP
17cuprophan459.3SELP, VCAM1, ITGAL, ICAM1
18tolmetin45 1110.3MPO, OXA1L, ALB
19slex459.3ICAM1, ITGAL, VCAM1, SELP
20rantes459.3CCR1, ICAM1, ITGAL, CD40LG
21leukotriene b445 60 2411.3SELP, MPO, ITGAL, CCR1
22aopp459.3MPO, OXA1L, ALB
23slea459.2ICAM1, ITGAL, CD40LG, SELP
24hydroxyethyl starch459.2OXA1L, SELP, ALB
25pmma459.2SELP, CD40LG, OXA1L
26pirprofen459.2ALB, OXA1L
27fluvastatin45 50 29 1112.2SELP, VCAM1, ITGAL, ICAM1
28n-formylmethionyl-leucylphenylalanine459.2ICAM1, ITGAL, MPO, SELP
29dextran sulfate459.2CCR5, ICAM1, MPO, CD40LG, SELP
30carbohydrates459.1C4B, CD40LG, CFI, VCAM1, SELP
31n acetylcysteine459.1ICAM1, MPO, CD40LG, VCAM1, SELP
32cocaine45 1110.1CCR5, CD40LG, VCAM1, SELP
33polysaccharide459.0CCR5, ICAM1, CD40LG, VCAM1, SELP
34halothane45 29 1111.0OXA1L, FTH1, SELP, ALB
35ascorbic acid45 249.9ICAM1, MPO, FTH1, CD40LG, ALB
36simvastatin45 50 60 29 11 2413.9CCR5, ICAM1, ITGAL, VCAM1, SELP
37pravastatin45 50 29 11 2412.9ICAM1, ITGAL, CD40LG, VCAM1, SELP
38fmlp458.9ICAM1, ITGAL, MPO, VCAM1, SELP
39tolmetin glucuronide458.9ALB, OXA1L
40cytochalasin d45 609.8VCAM1, ITGAL, ICAM1, CCR5
41hyaluronic acid45 249.7ICAM1, ITGAL, CD40LG, VCAM1, ALB
42lactate458.7ICAM1, MPO, CD40LG, VCAM1, SELP, ALB
43actinomycin d458.5CCR5, CCR1, ICAM1, ITGAL, CD40LG
44polyethylene glycol458.5ICAM1, MPO, OXA1L, CD40LG, ALB
45histamine45 29 2410.4CCR5, ICAM1, MPO, CD40LG, VCAM1, SELP
46cholesterol45 29 11 2411.4CCR5, ITGAL, CFI, VCAM1, SELP, ALB
47heparin45 29 11 2411.2SELP, CCR5, CCR1, ITGAL, MPO, CD40LG
48retinoic acid45 248.8CCR5, CCR1, ICAM1, ITGAL, MPO, CD40LG
49cysteine457.4CCR5, CCR1, ITGAL, OXA1L, CD40LG, VCAM1
50fibrinogen457.4ICAM1, ITGAL, OXA1L, CD40LG, CFI, VCAM1

GO Terms for genes affiliated with Immune-Complex Glomerulonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.6SELP, CCR5, CCR1, ICAM1, ITGAL, CD40LG
2extracellular spaceGO:0056157.6C4B, MPO, CD40LG, CFI, VCAM1, SELP

Biological processes related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:0024079.9CCR1, CCR5
2leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
3membrane to membrane dockingGO:0226149.8ICAM1, VCAM1
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:0022919.6ITGAL, ICAM1
5heterophilic cell-cell adhesionGO:0071579.1ICAM1, ITGAL, VCAM1, SELP
6regulation of immune responseGO:0507768.9ICAM1, ITGAL, CD40LG, VCAM1
7leukocyte migrationGO:0509008.9SELP, ITGAL, ICAM1
8leukocyte cell-cell adhesionGO:0071598.7SELP, VCAM1, CD40LG, ITGAL, ICAM1
9cell adhesionGO:0071558.7CCR1, ICAM1, ITGAL, VCAM1, SELP
10inflammatory responseGO:0069548.3CCR5, CCR1, C4B, ITGAL, CD40LG, SELP

Molecular functions related to Immune-Complex Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:0717919.9CCR1, CCR5
2chemokine receptor activityGO:0049509.9CCR1, CCR5
3C-C chemokine bindingGO:0199579.8CCR1, CCR5
4C-C chemokine receptor activityGO:0164939.6CCR1, CCR5

Products for genes affiliated with Immune-Complex Glomerulonephritis

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Sources for Immune-Complex Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet