Aliases & Classifications for Immune System Disease

MalaCards integrated aliases for Immune System Disease:

Name: Immune System Disease 12 14
Abnormality of the Immune System 28
Immune System and Disorders 40
Immune System Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2914
ICD10 32 D89.9
ICD9CM 34 279 279.9

Summaries for Immune System Disease

MedlinePlus : 40 Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them. If your immune system cannot do its job, the results can be serious. Disorders of the immune system include Allergy and asthma - immune responses to substances that are usually not harmful Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Immune System Disease, also known as abnormality of the immune system, is related to immune deficiency disease and temporal arteritis, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Immune System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include the immune system, b cells and t cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A disease of anatomical entity that is located in the immune system.

Related Diseases for Immune System Disease

Diseases related to Immune System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 immune deficiency disease 33.3 CD40LG CD79A IL2 IL4 TNF
2 temporal arteritis 32.2 APOH CD40LG IL6
3 autoimmune disease 31.8 APOH CD40LG CD79A IL2 IL4 IL5
4 hypersensitivity reaction disease 31.6 ALB APOH CD40LG CD79A IL2 IL4
5 complement component 3 deficiency, autosomal recessive 11.2
6 ocular toxoplasmosis 10.9 CD40LG CD79A TLR9
7 cerebral arteritis 10.9 CD40LG CD79A VWF
8 selective igg deficiency disease 10.9 CD40LG CD79A
9 cork-handlers' disease 10.9 ALB CD40LG CD79A
10 c1q nephropathy 10.9 CD40LG CD79A
11 monoclonal paraproteinemia 10.9 CD40LG CD79A VWF
12 heparin-induced thrombocytopenia 10.9 CD40LG F3 SERPINC1
13 livedoid vasculopathy 10.9 APOH CD40LG F2
14 immunoglobulin a deficiency 1 10.9 CD40LG CD79A IL4
15 spinal cord infarction 10.9 APOH F2 SERPINC1
16 intestinal impaction 10.9 F2 F3 SERPINC1
17 von willebrand disease, type 1 10.8 F2 F3 VWF
18 qualitative platelet defect 10.8 F2 F3 VWF
19 parasitic ichthyosporea infectious disease 10.8 CD40LG CD79A IL4
20 leech infestation 10.8 F2 F3 SERPINC1
21 congenital hypogammaglobulinemia 10.8 CD40LG CD79A IL4
22 hantavirus pulmonary syndrome 10.8 CD40LG F2 F3
23 rhinosporidiosis 10.8 CD40LG CD79A IL4
24 giant hemangioma 10.8 F2 F3 SERPINC1
25 cerebral sinovenous thrombosis 10.8 APOH F2 F3
26 orbital granuloma 10.8 CD40LG CD79A CSF3
27 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A IL6
28 sagittal sinus thrombosis 10.8 F2 F3 SERPINC1
29 antipyrine metabolism 10.8 ALB F2
30 prothrombin deficiency, congenital 10.8 APOH F2 SERPINC1
31 sudden sensorineural hearing loss 10.8 F2 IL6 SERPINC1
32 blue toe syndrome 10.8 F2 F3 SERPINC1
33 intracranial embolism 10.8 F2 F3 SERPINC1
34 immunodeficiency with hyper-igm, type 1 10.8 CD40LG CD79A IL4
35 jejunoileitis 10.8 CD40LG CD79A TNF
36 catastrophic antiphospholipid syndrome 10.8 APOH CD40LG F3
37 non-a-e hepatitis 10.8 ALB F2
38 diffuse glomerulonephritis 10.8 ALB CD40LG CD79A
39 cough variant asthma 10.8 IL4 IL5 TRPV1
40 marantic endocarditis 10.8 F2 F3 SERPINC1
41 ischemic colitis 10.8 APOH F2 SERPINC1
42 acute salpingitis 10.8 CD40LG CD79A TNF
43 non-secretory myeloma 10.8 ALB CD40LG CD79A
44 arteriovenous fistula 10.8 APOH EPO IL6
45 legionnaires' disease 10.8 ALB CD40LG TLR9
46 meningovascular neurosyphilis 10.8 CD40LG CD79A
47 sneddon syndrome 10.8 APOH F2 SERPINC1
48 purpura fulminans 10.8 F2 F3 SERPINC1
49 colorado tick fever 10.8 ALB CD40LG
50 retinal artery occlusion 10.8 APOH F2 SERPINC1

Graphical network of the top 20 diseases related to Immune System Disease:



Diseases related to Immune System Disease

Symptoms & Phenotypes for Immune System Disease

UMLS symptoms related to Immune System Disease:


pathological conditions, signs and symptoms

MGI Mouse Phenotypes related to Immune System Disease:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 TLR9 TNF TRPV1 VWF ALB APOH
2 hematopoietic system MP:0005397 10.36 CD40LG CD79A CSF3 EPO F2 F3
3 immune system MP:0005387 10.31 IL5 IL6 SERPINC1 THPO TLR9 TNF
4 cellular MP:0005384 10.27 TLR9 TNF TRPV1 VWF ALB CD40LG
5 cardiovascular system MP:0005385 10.21 CD40LG EPO F2 F3 IL2 IL6
6 digestive/alimentary MP:0005381 10.13 ALB F2 IL2 IL4 IL5 IL6
7 mortality/aging MP:0010768 10.1 ALB APOH CD40LG EPO F2 F3
8 integument MP:0010771 10.02 CD40LG CSF3 EPO F2 F3 IL4
9 liver/biliary system MP:0005370 10.02 ALB CD79A EPO IL2 IL4 IL5
10 neoplasm MP:0002006 9.76 F3 IL2 IL5 IL6 TNF TRPV1
11 renal/urinary system MP:0005367 9.61 ALB CD40LG CD79A CSF3 IL4 IL6
12 respiratory system MP:0005388 9.23 EPO F2 F3 IL2 IL4 IL5

Drugs & Therapeutics for Immune System Disease

Drugs for Immune System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1383)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
3
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
4
Dimenhydrinate Approved Phase 4,Phase 1,Phase 2 523-87-5 441281
5
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
6
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
7 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 329-65-7
8
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
9
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
10
Fludrocortisone Approved, Investigational Phase 4 127-31-1 31378
11
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
12
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 111025-46-8 4829
13
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2 7782-49-2
14
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 242138-07-4
15
Linagliptin Approved Phase 4 668270-12-0 10096344
16
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 4091 14219
17
Voglibose Approved, Investigational Phase 4 83480-29-9 444020
18
Enalapril Approved, Vet_approved Phase 4,Phase 2 75847-73-3 40466924 5362032
19
Enalaprilat Approved Phase 4,Phase 2 76420-72-9 6917719
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
22
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
23
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
24
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
25
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
26
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
27
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
28
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
29
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-45-6, 75614-87-8 774
30
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
31
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-23-7 657311 5754
32 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
33
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
34
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
35
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
36
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
37
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
38
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
39
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
40
Glyburide Approved Phase 4,Phase 2,Phase 3 10238-21-8 3488
41
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
42
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
43
Levocetirizine Approved Phase 4,Phase 3,Phase 1,Phase 2 130018-77-8
44
Azathioprine Approved Phase 4,Phase 2,Phase 3,Phase 1 446-86-6 2265
45
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
46
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
47
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
48
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
49
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
50
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652

Interventional clinical trials:

(show top 50) (show all 10000)

# Name Status NCT ID Phase Drugs
1 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
2 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
3 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
4 TBE Vaccination in Allergic Patients Unknown status NCT02511535 Phase 4
5 TRPV Expression in Subjects With Sensitive Skin Unknown status NCT01871883 Phase 4
6 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
7 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
8 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
9 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
10 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
11 Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity Unknown status NCT01736202 Phase 4
12 Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Unknown status NCT01253928 Phase 4 Pioglitazone
13 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
14 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
15 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
16 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
17 Diagnostic Immunization With Rabies Vaccine in Patients With PID Unknown status NCT02490956 Phase 4
18 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
19 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
20 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
21 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
22 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
23 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
24 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
25 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
26 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4 alacaftadine and naphazoline HCl & pheniramine maleate
27 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4 Bepreve (bepotastine ophthalmic solution) 1.5%
28 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4 Bepotastine
29 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
30 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
31 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
32 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
33 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
34 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
35 The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria Unknown status NCT00346606 Phase 4 Denosin® and Xyzal®
36 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
37 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
38 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4 azathioprine
39 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
40 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
41 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
42 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
43 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
44 Targeted Ultrasound in Rheumatoid Arthritis Unknown status NCT02056184 Phase 4 Adalimumab
45 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
46 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
47 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
48 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
49 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
50 Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT01548001 Phase 4 Iguratimod;Methotrexate

Search NIH Clinical Center for Immune System Disease

Genetic Tests for Immune System Disease

Genetic tests related to Immune System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Immune System 28

Anatomical Context for Immune System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Disease:

18
The Immune System

MalaCards organs/tissues related to Immune System Disease:

38
B Cells, T Cells, Testes, Bone, Bone Marrow, Skin, Pancreas

Publications for Immune System Disease

Variations for Immune System Disease

Expression for Immune System Disease

Search GEO for disease gene expression data for Immune System Disease.

Pathways for Immune System Disease

Pathways related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CD40LG CSF3 EPO F2 IL2 IL4
2
Show member pathways
13.43 CD40LG CSF3 IL2 IL4 IL5 IL6
3
Show member pathways
13.38 CD40LG CSF3 IL2 IL4 IL5 IL6
4
Show member pathways
13.32 CD40LG CSF3 IL2 IL4 IL5 IL6
5
Show member pathways
13.27 ALB APOH F2 F3 IL2 IL5
6
Show member pathways
12.99 CSF3 EPO IL2 IL4 IL6 TNF
7
Show member pathways
12.88 CD40LG IL2 IL4 IL5 IL6 TNF
8
Show member pathways
12.77 IL2 IL4 IL6 THPO TNF
9
Show member pathways
12.73 CD40LG IL2 IL6 THPO TLR9 TNF
10
Show member pathways
12.65 CD40LG CD79A IL2 IL4 TNF
11
Show member pathways
12.61 IL2 IL4 IL5 IL6 TNF
12 12.58 CD40LG CD79A IL2 IL4 TLR9 TNF
13
Show member pathways
12.44 CD40LG IL2 IL4 IL5 IL6 TNF
14
Show member pathways
12.36 CSF3 IL4 IL5 IL6 TNF
15
Show member pathways
12.35 ALB F2 IL2 IL4 IL6 TNF
16
Show member pathways
12.25 CSF3 EPO IL2 IL4 IL5 IL6
17
Show member pathways
12.21 IL4 IL6 TLR9 TNF
18
Show member pathways
12.18 F2 F3 SERPINC1 VWF
19
Show member pathways
12.17 IL2 IL4 IL5 IL6 TNF
20 12.12 F2 F3 SERPINC1 VWF
21 12.04 IL2 IL4 IL6 TNF
22
Show member pathways
11.97 IL2 IL6 TLR9 TNF
23 11.83 IL2 IL4 IL5 IL6
24 11.82 IL2 IL4 IL5 TNF
25 11.78 IL2 IL6 TLR9 TNF
26
Show member pathways
11.74 CD40LG IL2 IL4 IL5 TNF
27
Show member pathways
11.7 CD40LG IL2 IL6 TNF
28 11.69 CSF3 EPO IL4 IL5 IL6 THPO
29 11.67 CD40LG IL4 IL5
30 11.63 CSF3 IL4 IL5 IL6 TNF
31 11.57 IL2 IL6 TNF
32 11.57 CSF3 IL4 IL6 TNF
33 11.55 CSF3 EPO IL5 IL6
34 11.55 CD40LG IL4 IL5 IL6 TLR9 TNF
35 11.54 EPO IL6 TF
36 11.51 IL2 IL4 IL5
37 11.49 CD40LG CSF3 IL6 TLR9 TNF
38 11.39 IL6 TLR9 TNF
39 11.34 CD40LG IL2 IL4 IL5
40 11.34 CD79A CSF3 EPO IL2 IL4 IL5
41 11.32 IL4 IL5 IL6 TNF
42 11.23 IL2 IL4 IL5
43 11.14 CD40LG CSF3 IL2 IL4 IL5 IL6
44 10.98 CD40LG CSF3 IL2 IL4 IL5 IL6
45 10.91 CSF3 IL2 IL4 IL5 IL6 TNF
46 10.84 IL4 IL5 IL6

GO Terms for Immune System Disease

Cellular components related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 ALB APOH CD40LG CSF3 EPO F2
2 cell surface GO:0009986 9.8 APOH CD40LG EPO F3 TF TNF
3 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TF
4 endoplasmic reticulum lumen GO:0005788 9.65 ALB F2 IL6 SERPINC1 TF
5 external side of plasma membrane GO:0009897 9.55 CD40LG CD79A F2 TNF TRPV1
6 extracellular space GO:0005615 9.53 ALB APOH CD40LG CSF3 EPO F2

Biological processes related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.92 F2 F3 SERPINC1 VWF
2 positive regulation of protein phosphorylation GO:0001934 9.91 F2 IL2 THPO TNF
3 inflammatory response GO:0006954 9.91 CD40LG IL5 IL6 TLR9 TNF TRPV1
4 positive regulation of protein kinase B signaling GO:0051897 9.88 CSF3 F3 THPO TNF
5 cytokine-mediated signaling pathway GO:0019221 9.88 CSF3 F3 IL5 IL6
6 cellular protein metabolic process GO:0044267 9.88 ALB F2 IL6 SERPINC1 TF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 CD40LG IL6 TLR9 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 CSF3 IL6 TNF
9 platelet degranulation GO:0002576 9.83 ALB APOH TF VWF
10 B cell differentiation GO:0030183 9.81 CD40LG CD79A IL4
11 platelet activation GO:0030168 9.81 CD40LG F2 IL6 VWF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 EPO IL2 IL6
13 positive regulation of interleukin-6 production GO:0032755 9.78 IL6 TLR9 TNF
14 acute-phase response GO:0006953 9.73 EPO F2 IL6
15 immune response GO:0006955 9.7 CD40LG CSF3 IL2 IL4 IL5 IL6
16 regulation of blood coagulation GO:0030193 9.67 APOH F2 SERPINC1
17 positive regulation of T cell proliferation GO:0042102 9.67 CD40LG IL2 IL4 IL6
18 negative regulation of fibrinolysis GO:0051918 9.65 APOH F2
19 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
20 positive regulation of isotype switching to IgG isotypes GO:0048304 9.64 IL2 IL4
21 response to salt stress GO:0009651 9.64 EPO TNF
22 positive regulation of chemokine production GO:0032722 9.63 IL6 TLR9 TNF
23 negative regulation of myeloid cell apoptotic process GO:0033033 9.62 APOH EPO
24 positive regulation of STAT protein import into nucleus GO:2000366 9.6 F2 IL6
25 regulation of immunoglobulin secretion GO:0051023 9.59 CD40LG TNF
26 blood coagulation, intrinsic pathway GO:0007597 9.58 APOH F2 VWF
27 hemostasis GO:0007599 9.56 F2 F3 SERPINC1 VWF
28 positive regulation of immunoglobulin secretion GO:0051024 9.5 IL2 IL5 IL6
29 regulation of receptor activity GO:0010469 9.32 CD40LG CSF3 EPO F2 IL2 IL4
30 positive regulation of B cell proliferation GO:0030890 9.26 IL2 IL4 IL5 TLR9
31 negative regulation of apoptotic process GO:0043066 10.02 ALB CD40LG EPO IL2 IL4 IL6
32 positive regulation of cell proliferation GO:0008284 10.01 CSF3 EPO F2 IL2 IL5 IL6

Molecular functions related to Immune System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 CSF3 F2 IL2 IL4 IL5 IL6
2 protease binding GO:0002020 9.46 F3 SERPINC1 TNF VWF
3 cytokine activity GO:0005125 9.28 CD40LG CSF3 EPO IL2 IL4 IL5

Sources for Immune System Disease

3 CDC
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10 dbSNP
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16 ExPASy
18 FMA
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33 ICD10 via Orphanet
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37 LifeMap
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42 MESH via Orphanet
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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