Aliases & Classifications for Immune System Disease

MalaCards integrated aliases for Immune System Disease:

Name: Immune System Disease 12 14
Abnormality of the Immune System 29
Immune System and Disorders 41
Immune System Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2914
ICD10 33 D89.9
ICD9CM 35 279 279.9
UMLS 69 C0041806

Summaries for Immune System Disease

MedlinePlus : 41 your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. it helps your body to recognize these "foreign" invaders. then its job is to keep them out, or if it can't, to find and destroy them. if your immune system cannot do its job, the results can be serious. disorders of the immune system include allergy and asthma - immune responses to substances that are usually not harmful immune deficiency diseases - disorders in which the immune system is missing one or more of its parts autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake nih: national institute of allergy and infectious diseases

MalaCards based summary : Immune System Disease, also known as abnormality of the immune system, is related to oculo-cerebral dysplasia and alcoholic neuropathy, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Immune System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A disease of anatomical entity that is located in the immune system.

Related Diseases for Immune System Disease

Diseases related to Immune System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)
id Related Disease Score Top Affiliating Genes
1 oculo-cerebral dysplasia 11.3 CD40LG CD79A TLR9
2 alcoholic neuropathy 11.2 CD40LG CD79A
3 calloso-genital dysplasia 11.2 CD40LG CD79A
4 microinvasive cervical squamous cell carcinoma 11.2 ALB CD40LG CD79A
5 colonic benign neoplasm 11.2 CD40LG CD79A VWF
6 hereditary amyloidosis 11.2 CD40LG F3 SERPINC1
7 lockwood feingold syndrome 11.2 APOH CD40LG F2
8 diabetic angiopathy 11.2 CD40LG CD79A IL4
9 pyridoxine deficiency anemia 11.2 F2 F3 SERPINC1
10 von willibrand disease, type 3 11.2 F2 F3 VWF
11 syncope 11.2 APOH F2 SERPINC1
12 aniseikonia 11.2 CD40LG CD79A IL4
13 polyneuropathy due to drug 11.2 CD40LG CD79A IL4
14 cutaneous ganglioneuroma 11.2 CD40LG CD79A IL4
15 myiasis 11.2 F2 F3 SERPINC1
16 testicular gonadoblastoma 11.2 F2 F3 SERPINC1
17 rectum neuroendocrine neoplasm 11.2 F2 F3 SERPINC1
18 46,xy ovotesticular disorder of sex development 11.2 APOH F2 F3
19 hypoparathyroidism, x-linked 11.2 CD40LG CD79A IL4
20 generalized atherosclerosis 11.2 CD40LG CD79A IL6
21 malignant otitis externa 11.2 CD40LG CD79A CSF3
22 uveitis 11.2 CD40LG CD79A TNF
23 midline cystocele 11.2 F2 F3 SERPINC1
24 non-hodgkin lymphoma, during pregnancy 11.2 ALB F2
25 ileocolitis 11.2 CD40LG CD79A TNF
26 superior limbic keratoconjunctivitis 11.2 F2 IL6 SERPINC1
27 immune-complex glomerulonephritis 11.2 ALB CD40LG CD79A
28 cavernous lymphangioma 11.2 APOH CD40LG F3
29 marasmus 11.2 IL4 IL5 TRPV1
30 collagenous colitis 11.2 APOH F2 SERPINC1
31 lymphatic system cancer 11.2 F2 F3 SERPINC1
32 facioscapulohumeral muscular dystrophy 1 11.2 F2 F3 VWF
33 variola major 11.2 CD40LG CD79A
34 hiv-1 11.2 APOH F2 SERPINC1
35 adrenal gland disease 11.2 ALB CD40LG CD79A
36 common cold 11.2 ALB CD40LG TLR9
37 discitis 11.2 CD40LG CD79A TNF
38 mu chain disease 11.2 CD40LG CD79A
39 asphyxia neonatorum 11.2 APOH EPO IL6
40 middle ear carcinoma 11.2 ALB CD40LG
41 glutathioninuria 11.2 APOH F2 SERPINC1
42 lethal congenital contracture syndrome 11.2 F2 F3 SERPINC1
43 rheumatoid lung disease 11.2 APOH F2 SERPINC1
44 rabies 11.2 CD40LG CD79A
45 scirrhous adenocarcinoma 11.2 IL2 TNF
46 epididymis adenocarcinoma 11.2 CD40LG IL4 IL5
47 ariboflavinosis 11.2 CD40LG CD79A IL6
48 oropharyngeal cancer, childhood 11.2 CD79A IL4 TNF
49 cataract 11.2 ALB SERPINC1 TNF
50 familial retinoblastoma 11.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Immune System Disease:



Diseases related to Immune System Disease

Symptoms & Phenotypes for Immune System Disease

UMLS symptoms related to Immune System Disease:


pathological conditions, signs and symptoms

MGI Mouse Phenotypes related to Immune System Disease:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 THPO TLR9 TNF TRPV1 VWF ALB
2 hematopoietic system MP:0005397 10.36 CD40LG CD79A CSF3 EPO F2 F3
3 immune system MP:0005387 10.31 IL4 IL5 IL6 SERPINC1 THPO TLR9
4 cellular MP:0005384 10.27 ALB CD40LG CD79A EPO F3 IL2
5 cardiovascular system MP:0005385 10.21 CD40LG EPO F2 F3 IL2 IL6
6 digestive/alimentary MP:0005381 10.13 ALB F2 IL2 IL4 IL5 IL6
7 mortality/aging MP:0010768 10.1 TNF VWF ALB APOH CD40LG EPO
8 integument MP:0010771 10.02 CD40LG CSF3 EPO F2 F3 IL4
9 liver/biliary system MP:0005370 10.02 ALB CD79A EPO IL2 IL4 IL5
10 neoplasm MP:0002006 9.76 ALB CD79A F3 IL2 IL5 IL6
11 renal/urinary system MP:0005367 9.61 ALB CD40LG CD79A CSF3 IL4 IL6
12 respiratory system MP:0005388 9.23 IL5 IL6 TNF EPO F2 F3

Drugs & Therapeutics for Immune System Disease

Drugs for Immune System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1392)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
3
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
4
Dimenhydrinate Approved Phase 4,Phase 1,Phase 2 523-87-5 441281
5
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
6
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
7
Simvastatin Approved Phase 4,Phase 2,Phase 1 79902-63-9 54454
8
Fludrocortisone Approved Phase 4 127-31-1 31378
9
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 111025-46-8 4829
10
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 242138-07-4
11
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
12
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
13
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 446-86-6 2265
14
Febuxostat Approved Phase 4,Phase 3 144060-53-7 134018
15
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
16
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Early Phase 1 55-63-0 4510
17
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
18
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
19
Enalapril Approved, Vet_approved Phase 4,Phase 2 75847-73-3 5362032 40466924
20
Enalaprilat Approved Phase 4,Phase 2 76420-72-9 6917719
21
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
22
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
23
Linagliptin Approved Phase 4 668270-12-0 10096344
24
Metformin Approved Phase 4,Phase 3,Phase 1 657-24-9 14219 4091
25
Voglibose Approved, Investigational Phase 4 83480-29-9 444020
26
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
27
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1 160337-95-1
28
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
29
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
30
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
31
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
32
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 204656-20-2 44147092
33
Glyburide Approved Phase 4,Phase 2,Phase 3 10238-21-8 3488
34
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
35
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
36
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
37
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
38
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
39
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 439542 10909430
40
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
41
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
42
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 130018-77-8
43
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
44
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
45
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1 192725-17-0 92727
46
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
47
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
48
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
49
Selenium Approved, Vet_approved Phase 4,Phase 2,Phase 3 7782-49-2
50
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899

Interventional clinical trials:

(show top 50) (show all 10000)

id Name Status NCT ID Phase Drugs
1 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
2 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4 Human papilloma virus vaccine (cervarix)
3 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
4 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
5 TBE Vaccination in Allergic Patients Unknown status NCT02511535 Phase 4
6 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
7 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
8 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
9 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
10 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
11 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4 Fludrocortisone
12 Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity Unknown status NCT01736202 Phase 4
13 Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Unknown status NCT01253928 Phase 4 Pioglitazone
14 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
15 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
16 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
17 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
18 Diagnostic Immunization With Rabies Vaccine in Patients With PID Unknown status NCT02490956 Phase 4
19 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
20 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4 azathioprine
21 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4 Febuxostat
22 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
23 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
24 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
25 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
26 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
27 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
28 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
29 52 Week Trial of Liraglutide in Type 1 Diabetes Unknown status NCT01787916 Phase 4 Liraglutide
30 Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 DM Unknown status NCT01338922 Phase 4
31 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
32 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
33 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
34 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
35 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
36 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4 alacaftadine and naphazoline HCl & pheniramine maleate
37 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4 Bepreve (bepotastine ophthalmic solution) 1.5%
38 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4 Bepotastine
39 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
40 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
41 The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria Unknown status NCT00346606 Phase 4 Denosin® and Xyzal®
42 Impact of Vitamin A on Multiple Sclerosis (MS) Unknown status NCT01417273 Phase 4 Drug: placebo
43 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
44 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
45 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
46 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
47 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
48 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
49 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
50 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4

Search NIH Clinical Center for Immune System Disease

Genetic Tests for Immune System Disease

Genetic tests related to Immune System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Immune System 29

Anatomical Context for Immune System Disease

MalaCards organs/tissues related to Immune System Disease:

39
B Cells, T Cells, Bone, Testes, Bone Marrow, Skin, Kidney

Publications for Immune System Disease

Variations for Immune System Disease

Expression for Immune System Disease

Search GEO for disease gene expression data for Immune System Disease.

Pathways for Immune System Disease

Pathways related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 44)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 CD40LG CSF3 EPO F2 IL2 IL4
2
Show member pathways
13.42 CD40LG CSF3 IL2 IL4 IL5 IL6
3
Show member pathways
13.38 CD40LG CSF3 IL2 IL4 IL5 IL6
4
Show member pathways
13.31 CD40LG CSF3 IL2 IL4 IL5 IL6
5
Show member pathways
13.25 ALB APOH F2 F3 IL2 IL5
6
Show member pathways
12.87 CD40LG IL2 IL4 IL5 IL6 TNF
7
Show member pathways
12.78 IL2 IL4 IL6 THPO TNF
8
Show member pathways
12.72 CD40LG IL2 IL6 THPO TLR9 TNF
9 12.69 CSF3 EPO IL2 IL4 IL6 TNF
10
Show member pathways
12.64 CD40LG CD79A IL2 IL4 TNF
11
Show member pathways
12.61 IL2 IL4 IL5 IL6 TNF
12 12.55 CD40LG CD79A IL2 IL4 TLR9 TNF
13
Show member pathways
12.41 CD40LG IL2 IL4 IL5 IL6 TNF
14
Show member pathways
12.35 CSF3 IL4 IL5 IL6 TNF
15
Show member pathways
12.2 IL4 IL6 TLR9 TNF
16
Show member pathways
12.18 F2 F3 SERPINC1 VWF
17
Show member pathways
12.14 IL2 IL4 IL5 IL6 TNF
18 12.11 F2 F3 SERPINC1 VWF
19
Show member pathways
12.1 CSF3 EPO IL2 IL4 IL5 IL6
20 12.03 IL2 IL4 IL6 TNF
21
Show member pathways
11.97 IL2 IL6 TLR9 TNF
22 11.82 IL2 IL4 IL5 IL6
23 11.8 IL2 IL4 IL5 TNF
24 11.77 IL2 IL6 TLR9 TNF
25
Show member pathways
11.74 CD40LG IL2 IL4 IL5 TNF
26 11.69 CSF3 EPO IL4 IL5 IL6 THPO
27
Show member pathways
11.68 CD40LG IL2 IL6 TNF
28 11.67 CD40LG IL4 IL5
29 11.63 CSF3 IL4 IL5 IL6 TNF
30 11.58 CD40LG IL4 IL5 IL6 TLR9 TNF
31 11.57 IL2 IL6 TNF
32 11.55 CSF3 IL4 IL6 TNF
33 11.54 EPO IL6 TF
34 11.53 CSF3 EPO IL5 IL6
35 11.52 IL2 IL4 IL5
36 11.49 CD40LG CSF3 IL6 TLR9 TNF
37 11.38 IL6 TLR9 TNF
38 11.34 CD79A CSF3 EPO IL2 IL4 IL5
39 11.33 CD40LG IL2 IL4 IL5
40 11.3 IL4 IL5 IL6 TNF
41 11.22 IL2 IL4 IL5
42 11.14 CD40LG CSF3 IL2 IL4 IL5 IL6
43 10.92 IL4 IL5 IL6
44 10.91 CSF3 IL2 IL4 IL5 IL6 TNF

GO Terms for Immune System Disease

Cellular components related to Immune System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 ALB APOH CD40LG CSF3 EPO F2
2 cell surface GO:0009986 9.8 APOH CD40LG EPO F3 TF TNF
3 external side of plasma membrane GO:0009897 9.7 CD40LG CD79A F2 IL4 IL6 TNF
4 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TF
5 endoplasmic reticulum lumen GO:0005788 9.65 ALB F2 IL6 SERPINC1 TF
6 extracellular space GO:0005615 9.53 ALB APOH CD40LG CSF3 EPO F2

Biological processes related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 45)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CD40LG IL5 IL6 TLR9 TNF TRPV1
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 EPO IL6 THPO TNF
3 blood coagulation GO:0007596 9.96 F2 F3 SERPINC1 VWF
4 cytokine-mediated signaling pathway GO:0019221 9.94 CSF3 F3 IL5 IL6
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 CD40LG IL6 TLR9 TNF
6 cellular protein metabolic process GO:0044267 9.93 ALB F2 IL6 SERPINC1 TF
7 positive regulation of cell proliferation GO:0008284 9.91 CSF3 EPO F2 IL2 IL4 IL5
8 platelet degranulation GO:0002576 9.9 ALB APOH TF VWF
9 platelet activation GO:0030168 9.89 CD40LG F2 IL6 VWF
10 response to wounding GO:0009611 9.87 F2 IL6 VWF
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.87 IL4 IL5 IL6 TNF
12 B cell differentiation GO:0030183 9.85 CD40LG CD79A IL4
13 negative regulation of neuron death GO:1901215 9.83 CSF3 EPO IL6
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 CSF3 IL4 IL5 IL6
15 positive regulation of interleukin-6 production GO:0032755 9.82 IL6 TLR9 TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL6 TNF TRPV1
17 positive regulation of protein phosphorylation GO:0001934 9.8 F2 IL2 IL4 THPO TNF
18 acute-phase response GO:0006953 9.79 EPO F2 IL6
19 positive regulation of activated T cell proliferation GO:0042104 9.76 EPO IL2 IL4
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 EPO IL2 IL4 IL6
21 cellular response to cytokine stimulus GO:0071345 9.75 CSF3 IL6 TRPV1
22 positive regulation of interleukin-10 production GO:0032733 9.73 CD40LG IL4 TLR9
23 positive regulation of T cell proliferation GO:0042102 9.73 CD40LG IL2 IL4 IL6
24 regulation of blood coagulation GO:0030193 9.72 APOH F2 SERPINC1
25 positive regulation of podosome assembly GO:0071803 9.7 IL5 TNF
26 immune response GO:0006955 9.7 CD40LG CSF3 IL2 IL4 IL5 IL6
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.69 IL2 IL4
28 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL4 TNF
29 negative regulation of fibrinolysis GO:0051918 9.68 APOH F2
30 positive regulation of B cell activation GO:0050871 9.68 IL4 IL6
31 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
32 response to salt stress GO:0009651 9.67 EPO TNF
33 blood coagulation, intrinsic pathway GO:0007597 9.67 APOH F2 VWF
34 negative regulation of myeloid cell apoptotic process GO:0033033 9.65 APOH EPO
35 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
36 positive regulation of chemokine production GO:0032722 9.65 IL6 TLR9 TNF
37 regulation of immunoglobulin secretion GO:0051023 9.64 CD40LG TNF
38 negative regulation of T-helper 17 cell differentiation GO:2000320 9.62 IL2 IL4
39 positive regulation of mononuclear cell migration GO:0071677 9.62 IL4 TNF
40 hemostasis GO:0007599 9.56 F2 F3 SERPINC1 VWF
41 positive regulation of immunoglobulin secretion GO:0051024 9.5 IL2 IL5 IL6
42 positive regulation of immunoglobulin production GO:0002639 9.37 IL4
43 positive regulation of B cell proliferation GO:0030890 9.13 IL2 IL4 IL5
44 positive regulation of protein kinase B signaling GO:0051897 9.02 CSF3 F3 IL6 THPO TNF
45 negative regulation of apoptotic process GO:0043066 10.08 ALB CD40LG EPO IL2 IL4 IL6

Molecular functions related to Immune System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 CSF3 F2 IL2 IL4 IL5 IL6
2 protease binding GO:0002020 9.46 F3 SERPINC1 TNF VWF
3 cytokine activity GO:0005125 9.23 CD40LG CSF3 IL2 IL4 IL5 IL6

Sources for Immune System Disease

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42 MeSH
43 MESH via Orphanet
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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