MCID: IMM136
MIFTS: 51

Immune System Disease malady

Categories: Immune diseases

Aliases & Classifications for Immune System Disease

Summaries for Immune System Disease

MedlinePlus : 41 your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. it helps your body to recognize these "foreign" invaders. then its job is to keep them out, or if it can't, to find and destroy them. if your immune system cannot do its job, the results can be serious. disorders of the immune system include allergy and asthma - immune responses to substances that are usually not harmful immune deficiency diseases - disorders in which the immune system is missing one or more of its parts autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake nih: national institute of allergy and infectious diseases

MalaCards based summary : Immune System Disease, also known as immune system and disorders, is related to primary immunodeficiency disease and c3 deficiency, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Immune System Disease is RPS17 (Ribosomal Protein S17), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include the immune system, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A disease of anatomical entity that is located in the immune system.

Related Diseases for Immune System Disease

Diseases related to Immune System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
id Related Disease Score Top Affiliating Genes
1 primary immunodeficiency disease 11.4
2 c3 deficiency 11.0
3 vasculitis syndromes of the central and peripheral nervous systems 10.6
4 temporal arteritis 10.6
5 autoimmune disease of exocrine system 10.6
6 otulipenia 10.6
7 allergic hypersensitivity disease 10.6
8 hypersensitivity reaction type ii disease 10.6
9 lymphatic system disease 10.6
10 colloid adenoma 10.5 ALB CD40LG CD79A
11 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.5 CD40LG F3 SERPINC1
12 lubinsky syndrome 10.5 APOH CD40LG F2
13 alpha-2-macroglobulin deficiency 10.5 F2 F3 VWF
14 colonic benign neoplasm 10.5 CD40LG CD79A VWF
15 influenza 10.5 F2 F3 SERPINC1
16 alcoholic neuropathy 10.5 CD40LG CD79A
17 vascular erectile tumor 10.5 APOH F2 SERPINC1
18 camptodactyly vertebral fusion 10.5 CD40LG CD79A
19 striatonigral degeneration 10.5 ALB CD40LG CD79A
20 pancreatic ductal carcinoma 10.5 F2 F3 SERPINC1
21 prostatic hypertrophy 10.5 F2 F3 VWF
22 chorioretinal scar 10.5 F2 F3 SERPINC1
23 mixed hepatoblastoma 10.5 F2 F3 SERPINC1
24 generalized atherosclerosis 10.5 CD40LG CD79A IL6
25 sporotrichosis 10.5 CD40LG F2 F3
26 alkhurma hemorrhagic fever 10.5 CD40LG CD79A IL4
27 polyneuropathy due to drug 10.5 CD40LG CD79A IL4
28 cutaneous ganglioneuroma 10.5 CD40LG CD79A IL4
29 hendra virus infection 10.5 APOH F2 F3
30 may-hegglin anomaly 10.5 APOH F2 SERPINC1
31 hypoparathyroidism, x-linked 10.5 CD40LG CD79A IL4
32 dmd-related dilated cardiomyopathy 10.5 F2 F3 SERPINC1
33 degenerative disc disease 10.5 IL6 TNF VWF
34 left-right axis malformations 10.5 APOH F2 SERPINC1
35 beach ear 10.5 CD40LG CD79A CSF3
36 lymphocytic colitis 10.5 APOH F2 SERPINC1
37 uveitis 10.5 CD40LG CD79A TNF
38 atherosclerosis 10.5 APOH EPO IL6
39 midline cystocele 10.5 F2 F3 SERPINC1
40 atopic dermatitis 6 10.5 ALB CD79A
41 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.5 APOH F2 IL6
42 thrombophlebitis migrans 10.5 CD40LG CD79A IL5
43 central congenital hypothyroidism 10.5 APOH CD40LG F3
44 hypersensitivity vasculitis 10.5 CD40LG IL4 IL5
45 gastroduodenal crohn's disease 10.5 CD40LG CD79A TNF
46 tubular renal disease-cardiomyopathy syndrome 10.5 IL10 IL4 TNF
47 angiokeratoma 10.5 ALB CD40LG CD79A
48 nondystrophic myotonia 10.5 ALB F2
49 chronic mucocutaneous candidiasis 10.5 CD40LG CD79A F9
50 bullous skin disease 10.5 APOH F2 SERPINC1

Graphical network of the top 20 diseases related to Immune System Disease:



Diseases related to Immune System Disease

Symptoms & Phenotypes for Immune System Disease

UMLS symptoms related to Immune System Disease:


pathological conditions, signs and symptoms

MGI Mouse Phenotypes related to Immune System Disease:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.39 IL10 IL2 IL4 IL5 IL6 SERPINC1
2 homeostasis/metabolism MP:0005376 10.39 ALB APOH CD40LG CD79A EPO F2
3 immune system MP:0005387 10.31 CD79A CSF3 EPO F2 F3 F9
4 cardiovascular system MP:0005385 10.25 CD40LG EPO F2 F3 F9 IL10
5 cellular MP:0005384 10.24 ALB CD40LG CD79A EPO F3 IL10
6 digestive/alimentary MP:0005381 10.13 IL6 TNF VWF ALB F2 IL10
7 mortality/aging MP:0010768 10.13 CD40LG EPO F2 F3 F9 IL10
8 liver/biliary system MP:0005370 10.06 ALB CD79A EPO F9 IL10 IL2
9 integument MP:0010771 10.02 EPO F2 F3 IL10 IL4 IL6
10 neoplasm MP:0002006 9.76 ALB CD79A F3 IL10 IL2 IL5
11 reproductive system MP:0005389 9.61 CD40LG F2 IL10 IL2 IL4 IL5
12 respiratory system MP:0005388 9.28 EPO F2 F3 IL10 IL2 IL4

Drugs & Therapeutics for Immune System Disease

Drugs for Immune System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1112)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
3
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
4
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
5
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
6
Simvastatin Approved Phase 4,Phase 1 79902-63-9 54454
7
Fludrocortisone Approved Phase 4 127-31-1 31378
8
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 111025-46-8 4829
9
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 242138-07-4
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
11
Pancrelipase Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 53608-75-6
12
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
13
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
14
Febuxostat Approved Phase 4 144060-53-7 134018
15
Nitric Oxide Approved Phase 4 10102-43-9 145068
16
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Early Phase 1 55-63-0 4510
17
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
18
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
19
Linagliptin Approved Phase 4 668270-12-0 10096344
20
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
21
Voglibose Approved, Investigational Phase 4 83480-29-9 444020
22
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
23
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1 160337-95-1
24
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
25
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1 133107-64-9
26
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
27
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 204656-20-2
28
Glyburide Approved Phase 4,Phase 2,Phase 3 10238-21-8 3488
29
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
30
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
31
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
32
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
33
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
34
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 439542 10909430
35 Sodium thiosulfate Approved Phase 4
36
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
37
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
38
Levocetirizine Approved Phase 4,Phase 3,Phase 2 130018-77-8
39
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
40
Lopinavir Approved Phase 4,Phase 3 192725-17-0 92727
41
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2 147127-20-6 464205
42
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
43
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
44
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
45
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
46
Selenium Approved, Vet_approved Phase 4,Phase 2 7782-49-2
47
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
48
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
49
Asparaginase Approved Phase 4,Phase 3,Phase 2 9015-68-3
50
Cladribine Approved, Investigational Phase 4,Phase 2 4291-63-8 20279

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4
2 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4
3 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4
4 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4
5 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4
6 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4
7 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4
8 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4
9 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4
10 Fludrocortisone's Test in Salt Sensitivity Unknown status NCT01453959 Phase 4
11 Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity Unknown status NCT01736202 Phase 4
12 Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD Unknown status NCT01253928 Phase 4
13 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4
14 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4
15 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
16 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4
17 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
18 Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas Unknown status NCT02003274 Phase 4
19 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4
20 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4
21 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4
22 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4
23 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4
24 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4
25 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4
26 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4
27 52 Week Trial of Liraglutide in Type 1 Diabetes Unknown status NCT01787916 Phase 4
28 Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 DM Unknown status NCT01338922 Phase 4
29 Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (The CGM TIME Trial) Unknown status NCT01295788 Phase 4
30 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4
31 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
32 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4
33 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4
34 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4
35 The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer Unknown status NCT01346371 Phase 4
36 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4
37 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4
38 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4
39 The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria Unknown status NCT00346606 Phase 4
40 Impact of Vitamin A on Multiple Sclerosis (MS) Unknown status NCT01417273 Phase 4
41 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4
42 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4
43 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4
44 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
45 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
46 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
47 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4
48 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
49 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4
50 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4

Search NIH Clinical Center for Immune System Disease

Genetic Tests for Immune System Disease

Genetic tests related to Immune System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Immune System 29

Anatomical Context for Immune System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Immune System Disease:

18
The Immune System

Publications for Immune System Disease

Variations for Immune System Disease

Expression for Immune System Disease

Search GEO for disease gene expression data for Immune System Disease.

Pathways for Immune System Disease

Pathways related to Immune System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CD40LG CSF3 EPO F2 IL10 IL2
2
Show member pathways
13.59 EPO F2 IL10 IL2 IL4 IL5
3
Show member pathways
13.48 CD40LG CSF3 IL10 IL2 IL4 IL5
4
Show member pathways
13.42 CD40LG CSF3 IL10 IL2 IL4 IL5
5
Show member pathways
13.33 CD40LG CSF3 IL10 IL2 IL4 IL5
6
Show member pathways
13.27 ALB APOH F2 F3 F9 IL2
7
Show member pathways
12.89 CD40LG IL10 IL2 IL4 IL5 IL6
8
Show member pathways
12.73 CD40LG IL2 IL6 THPO TNF
9
Show member pathways
12.7 CD40LG CD79A IL10 IL2 IL4 TNF
10
Show member pathways
12.67 IL10 IL2 IL4 IL5 IL6 TNF
11 12.66 CSF3 EPO IL2 IL4 IL6 VWF
12
Show member pathways
12.63 F2 IL10 IL2 IL6 TNF
13 12.6 CD40LG CD79A IL10 IL2 IL4 TNF
14
Show member pathways
12.45 CD40LG IL10 IL2 IL4 IL5 IL6
15
Show member pathways
12.4 CSF3 IL4 IL5 IL6 TNF
16
Show member pathways
12.39 ALB F2 IL2 IL4 IL6 TNF
17
Show member pathways
12.28 CD40LG IL10 IL4 TNF
18
Show member pathways
12.23 F2 F3 F9 SERPINC1 VWF
19 12.22 IL10 IL6 TF TNF
20
Show member pathways
12.16 IL10 IL2 IL4 IL5 IL6 TNF
21 12.14 F2 F3 F9 SERPINC1 VWF
22 12.06 IL2 IL4 IL6 TNF
23 12.04 IL10 IL4 IL6 TNF
24
Show member pathways
12.01 IL10 IL2 IL6 TNF
25
Show member pathways
12 CSF3 EPO IL10 IL2 IL4 IL5
26 11.88 IL2 IL4 IL5 IL6
27 11.84 IL10 IL2 IL6 TNF
28 11.84 IL10 IL2 IL4 IL5 TNF
29
Show member pathways
11.8 CD40LG IL2 IL4 IL5 TNF
30 11.79 CSF3 EPO IL4 IL5 IL6 THPO
31 11.77 IL10 IL6 TNF
32 11.77 EPO IL10 IL2 IL6
33 11.74 CD40LG IL10 IL4 IL5
34
Show member pathways
11.73 CD40LG IL2 IL6 TNF
35 11.71 CSF3 IL4 IL5 IL6 TNF
36 11.69 CD40LG IL10 IL4 IL5 IL6 TNF
37 11.59 IL2 IL6 TNF
38 11.57 CSF3 EPO IL5 IL6
39 11.56 EPO IL6 TF
40 11.56 IL10 IL2 IL4 IL5
41 11.52 CSF3 IL10 IL4 IL6 TNF
42 11.49 CD40LG CSF3 IL10 IL6 TNF
43
Show member pathways
11.47 IL10 IL2 TNF
44 11.41 IL10 IL6 TNF
45 11.41 IL10 IL6 TNF
46 11.39 CD40LG IL2 IL4 IL5
47 11.39 CD79A CSF3 EPO IL10 IL2 IL4
48 11.36 IL4 IL5 IL6 TNF
49 11.26 IL10 IL2 IL4 IL5
50 11.15 CD40LG CSF3 IL10 IL2 IL4 IL5

GO Terms for Immune System Disease

Cellular components related to Immune System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 ALB APOH CD40LG CSF3 EPO F2
2 cell surface GO:0009986 9.8 APOH CD40LG EPO F3 TF TNF
3 endoplasmic reticulum lumen GO:0005788 9.73 ALB F2 F9 IL6 SERPINC1 TF
4 blood microparticle GO:0072562 9.67 ALB F2 SERPINC1 TF
5 external side of plasma membrane GO:0009897 9.63 CD40LG CD79A F2 IL4 IL6 TNF
6 extracellular space GO:0005615 9.55 ALB APOH CD40LG CSF3 EPO F2

Biological processes related to Immune System Disease according to GeneCards Suite gene sharing:

(show all 50)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 EPO IL6 THPO TNF
2 negative regulation of apoptotic process GO:0043066 9.98 ALB CD40LG EPO IL10 IL2 IL4
3 cellular protein metabolic process GO:0044267 9.97 ALB F2 IL6 SERPINC1 TF
4 cytokine-mediated signaling pathway GO:0019221 9.95 CSF3 F3 IL5 IL6
5 positive regulation of cell proliferation GO:0008284 9.95 CSF3 EPO F2 IL2 IL4 IL5
6 blood coagulation GO:0007596 9.93 F2 F3 F9 SERPINC1 VWF
7 platelet degranulation GO:0002576 9.92 ALB APOH TF VWF
8 cellular response to lipopolysaccharide GO:0071222 9.91 CSF3 IL10 IL6 TNF
9 platelet activation GO:0030168 9.89 CD40LG F2 IL6 VWF
10 response to wounding GO:0009611 9.88 F2 IL6 VWF
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 CSF3 IL6 TNF
12 positive regulation of protein phosphorylation GO:0001934 9.88 F2 IL2 IL4 THPO TNF
13 response to glucocorticoid GO:0051384 9.87 IL10 IL6 TNF
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 CSF3 IL4 IL5 IL6
15 negative regulation of neuron death GO:1901215 9.84 CSF3 EPO IL6
16 B cell differentiation GO:0030183 9.81 CD40LG CD79A IL10 IL4
17 positive regulation of B cell proliferation GO:0030890 9.8 IL2 IL4 IL5
18 acute-phase response GO:0006953 9.8 EPO F2 IL6
19 positive regulation of T cell proliferation GO:0042102 9.8 CD40LG IL2 IL4 IL6
20 B cell proliferation GO:0042100 9.78 CD40LG CD79A IL10
21 positive regulation of activated T cell proliferation GO:0042104 9.76 EPO IL2 IL4
22 immune response GO:0006955 9.76 CD40LG CSF3 IL10 IL2 IL4 IL5
23 regulation of blood coagulation GO:0030193 9.73 APOH F2 SERPINC1
24 defense response to protozoan GO:0042832 9.72 IL10 IL4 IL6
25 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.72 IL10 IL4 IL5 IL6 TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL4 TNF
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
28 negative regulation of fibrinolysis GO:0051918 9.7 APOH F2
29 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.7 EPO IL2 IL4
30 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
31 response to salt stress GO:0009651 9.69 EPO TNF
32 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 IL4
34 negative regulation of myeloid cell apoptotic process GO:0033033 9.68 APOH EPO
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
36 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
37 type 2 immune response GO:0042092 9.67 IL10 IL4
38 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 EPO IL2 IL4 IL6
39 blood coagulation, extrinsic pathway GO:0007598 9.66 F3 F9
40 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
41 positive regulation of protein kinase B signaling GO:0051897 9.65 CSF3 F3 IL6 THPO TNF
42 regulation of isotype switching GO:0045191 9.64 IL10 IL4
43 negative regulation of T-helper 17 cell differentiation GO:2000320 9.64 IL2 IL4
44 positive regulation of mononuclear cell migration GO:0071677 9.63 IL4 TNF
45 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL5 IL6
46 receptor biosynthetic process GO:0032800 9.6 IL10 TNF
47 blood coagulation, intrinsic pathway GO:0007597 9.26 APOH F2 F9 VWF
48 hemostasis GO:0007599 9.02 F2 F3 F9 SERPINC1 VWF
49 positive regulation of transcription, DNA-templated GO:0045893 10.12 EPO IL10 IL4 IL5 IL6 TNF
50 inflammatory response GO:0006954 10.08 CD40LG IL10 IL5 IL6 TNF

Molecular functions related to Immune System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 CSF3 F2 IL10 IL2 IL4 IL5
2 protease binding GO:0002020 9.46 F3 SERPINC1 TNF VWF
3 cytokine activity GO:0005125 9.28 CD40LG CSF3 IL10 IL2 IL4 IL5

Sources for Immune System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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