IPSID
MCID: IMM054
MIFTS: 31

Immunoproliferative Small Intestinal Disease (IPSID) malady

Cancer, Gastrointestinal, Immune categories

Summaries for Immunoproliferative Small Intestinal Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Immunoproliferative disorders (also known as “immunoproliferative diseases” or... more...

MalaCards: Immunoproliferative Small Intestinal Disease, also known as mediterranean lymphoma, is related to alpha chain disease and alpha heavy-chain disease. An important gene associated with Immunoproliferative Small Intestinal Disease is TP53 (tumor protein p53), and among its related pathways are Wnt Signaling Pathway and Transcriptional misregulation in cancer. The compounds cyclophosphamide and vincristine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and nk cells, and related mouse phenotype reproductive system.

Aliases & Classifications for Immunoproliferative Small Intestinal Disease

Sources:
49Orphanet, 61UMLS, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal, Immune


Characteristics (Orphanet epidemiological data):

49
immunoproliferative small intestinal disease:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

immunoproliferative small intestinal disease 49 61
mediterranean lymphoma 49
ipsid 49


External Ids:

SNOMED-CT via Orphanet58 109982002, 109985000, 123313007 27461004, more
UMLS via Orphanet62 C0021071
MESH via Orphanet36 D007161
ICD10 via Orphanet26 C88.3
ICD1025 C88.3

Related Diseases for Immunoproliferative Small Intestinal Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Immunoproliferative Small Intestinal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1alpha chain disease10.8
2alpha heavy-chain disease10.7
3celiac disease10.3
4small intestine lymphoma10.3
5small intestinal sarcoma10.3
6sarcoma10.0TP53
7stomach cancer10.0TP53
8central nervous system lymphoma10.0BCL6
9gastric lymphoma10.0BCL6
10lymphoma, malt, somatic10.0BCL6
11myeloma10.0BCL6
12ataxia telangiectasia10.0TP53
13anaplastic large cell lymphoma10.0BCL6
14multiple myeloma10.0TP53, SDC1
15transitional cell carcinoma10.0BCL6, TP53
16b-cell chronic lymphocytic leukemia10.0BCL6, TP53
17b-cell lymphomas10.0TP53, BCL6

Graphical network of diseases related to Immunoproliferative Small Intestinal Disease:



Diseases related to immunoproliferative small intestinal disease

Clinical Features for Immunoproliferative Small Intestinal Disease

Drugs & Therapeutics for Immunoproliferative Small Intestinal Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Immunoproliferative Small Intestinal Disease

Drug clinical trials:

Search ClinicalTrials for Immunoproliferative Small Intestinal Disease

Search NIH Clinical Center for Immunoproliferative Small Intestinal Disease

Search CenterWatch for Immunoproliferative Small Intestinal Disease

Genetic Tests for Immunoproliferative Small Intestinal Disease

Anatomical Context for Immunoproliferative Small Intestinal Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Immunoproliferative Small Intestinal Disease:

33
Small intestine, Colon, Nk cells, T cells, B cells

Animal Models for Immunoproliferative Small Intestinal Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Immunoproliferative Small Intestinal Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.9TP53

Publications for Immunoproliferative Small Intestinal Disease

Sources:
51PubMed
See all sources

Articles related to Immunoproliferative Small Intestinal Disease:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
A rare cause of lymphadenopathy near the terminal ileum: immunoproliferative small intestinal disease. (22505392)
2012
2
Capsule-endoscopic findings in immunoproliferative small-intestinal disease. (22396282)
2012
3
Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. (20300878)
2010
4
Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression. (18277034)
2008
5
Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease. (16773719)
2006
6
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. (15542584)
2005
7
Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings. (16253033)
2005
8
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. (14724303)
2004
9
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. (15084705)
2004
10
Lymphomatous category of immunoproliferative small intestinal disease. (14616957)
2003
11
Re: Lin and Gray - immunoproliferative small intestinal disease. (12591078)
2003
12
Immunoproliferative small intestinal disease, two cases in the Northern Territory. (11783675)
2002
13
Is immunoproliferative small intestinal disease uncommon in India? (11398237)
2001
14
Malabsorption syndrome in a patient of Mediterranean origin; immunoproliferative small intestinal disease. (11334682)
2001
15
Immunoproliferative small intestinal disease: prolonged 30-year course without development of lymphoma. (11569710)
2001
16
Alpha-heavy chain disease, Mediterranean lymphoma, and immunoproliferative small intestinal disease: a review of clinicopathological features, pathogenesis, and differential diagnosis. (10235185)
1999
17
Primary low-grade lymphomas of the intestine. Case 1: immunoproliferative small intestinal disease. (10550167)
1999
18
Immunoproliferative small intestinal disease: case report and literature review. (10826015)
1999
19
Immunoproliferative small intestinal disease in South India: a clinical and immunomorphological study. (9918427)
1998
20
Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment. (9706780)
1998
21
Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. (8988128)
1997
22
Immunoproliferative small intestinal disease: a frequently missed diagnosis. (8935933)
1996
23
Clinicopathological features and management of immunoproliferative small intestinal disease and primary small intestinal lymphoma in Pakistan. (7674998)
1995
24
Combination chemotherapy with tetracycline and aggressive supportive care for immunoproliferative small-intestinal disease lymphoma. (7884437)
1995
25
Immunoproliferative small intestinal disease: Mediterranean lymphoma and alpha heavy chain disease. (8313111)
1994
26
Primary small-intestinal lymphomas in Taiwan: immunoproliferative small-intestinal disease and nonimmunoproliferative small-intestinal disease. (8021727)
1994
27
Immunoproliferative small intestinal disease or celiac disease. (8500754)
1993
28
Immunoproliferative small intestinal disease (IPSID) in Thailand. (8362283)
1993
29
Immunoproliferative small intestinal disease in an American patient with lymphoma and macroamylasemia. (1499909)
1992
30
Immunoproliferative small intestinal disease in Peru: treatment with oral tetracyclines. (1951397)
1991
31
Immunoproliferative small intestinal disease: a study of 13 cases with alpha heavy-chain disease. (2227833)
1990
32
The value of double-contrast study of the small intestine in immunoproliferative small intestinal disease. (2318388)
1990
33
Immunoproliferative small intestinal disease: portrait of a potentially preventable cancer from the Third World. (2145762)
1990
34
Immunoproliferative small intestinal disease (IPSID): relationships with alpha-chain disease and "Mediterranean" lymphomas. (2205943)
1990
35
Results of laparotomy in immunoproliferative small intestinal disease. (3349430)
1988
36
Malabsorption associated with nonmalignant immunoproliferative small intestinal disease. (3596077)
1987
37
Immunoproliferative small-intestinal disease: clinical features and outcome in 30 cases. (3683173)
1987
38
Immunoproliferative small-intestinal disease with lymphoma--diagnostic difficulties and pitfalls. Case reports. (3952594)
1986
39
Immunoproliferative small-intestinal disease. (3738650)
1986
40
Immunoproliferative small intestinal disease and primary small intestinal lymphoma. Relation to alpha chain protein. (3928129)
1985
41
Immunoproliferative small intestinal disease in Basenji dogs: morphologic observations. (6711978)
1984
42
Immunoproliferative small intestinal disease in Algerians. II. Ultrastructural studies in alpha-chain disease. (6434178)
1984
43
Lymphocyte transformation and humoral immune factors in Basenji dogs with immunoproliferative small intestinal disease. (6638652)
1983
44
In vitro immune cell function in six cases of immunoproliferative small intestinal disease after long term remission. (6225578)
1983
45
Immunoproliferative small intestinal disease. (6621657)
1983
46
Current concepts immunoproliferative small intestinal disease. A "Third-World lesion". (6405275)
1983
47
Immunoproliferative small intestinal disease in Algerians. I. Light microscopic and immunochemical studies. (6407746)
1983
48
Immunoproliferative small intestinal disease with duodenojejunal lymphoma: radiologic changes. (6773368)
1980
49
Endoscopic diagnosis of immunoproliferative small intestinal disease (IPSID). (7379761)
1980
50
"Mediterranean abdominal lymphoma" or immunoproliferative small intestinal disease. Part II: pathological aspects. (416903)
1978

Genetic Variations for Immunoproliferative Small Intestinal Disease

Expression for genes affiliated with Immunoproliferative Small Intestinal Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Immunoproliferative Small Intestinal Disease

Search GEO for disease gene expression data for Immunoproliferative Small Intestinal Disease.

Pathways for genes affiliated with Immunoproliferative Small Intestinal Disease

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Immunoproliferative Small Intestinal Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3BCL6, TP53
29.3TP53, BCL6
39.3TP53, BCL6
49.3TP53, BCL6
59.0SDC1, TP53

Compounds for genes affiliated with Immunoproliferative Small Intestinal Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Immunoproliferative Small Intestinal Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclophosphamide45 50 1111.3TP53, BCL6
2vincristine45 50 1111.0TP53, BCL6

GO Terms for genes affiliated with Immunoproliferative Small Intestinal Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Immunoproliferative Small Intestinal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0SDC1, TP53
2replication forkGO:0056579.0TP53, BCL6

Biological processes related to Immunoproliferative Small Intestinal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein import into nucleus, translocationGO:0000609.3TP53, BCL6
2positive regulation of apoptotic processGO:0430659.3TP53, BCL6
3negative regulation of cell growthGO:0303089.2TP53, BCL6
4response to DNA damage stimulusGO:0069749.0TP53, BCL6

Molecular functions related to Immunoproliferative Small Intestinal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.3TP53, BCL6

Products for genes affiliated with Immunoproliferative Small Intestinal Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Immunoproliferative Small Intestinal Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet