MCID: IMM053
MIFTS: 22

Immunotactoid Glomerulopathy malady

Categories: Rare diseases, Nephrological diseases, Immune diseases

Aliases & Classifications for Immunotactoid Glomerulopathy

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Sources:
65UMLS, 45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Immunotactoid Glomerulopathy:

Name: Immunotactoid Glomerulopathy 45 51
Immunotactoid Glomerulonephritis 45 51
 
Fibrillary Glomerulonephritis 65

Classifications:

Orphanet: 51 
Rare renal diseases


External Ids:

Orphanet51 97567
ICD10 via Orphanet28 N03.6
UMLS65 C0268749

Summaries for Immunotactoid Glomerulopathy

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NIH Rare Diseases:45 Immunotactoid glomerulopathy, also known as glomerulonephritis with organized monoclonal microtubular immunoglobulin deposits (gommid),  is a very uncommon cause of glomerular disease. it is related to a similar disease known as fibrillary glomerulopathy, which is more common. both disorders probably result from deposits derived from immunoglobulins, but in most cases the cause is idiopathic (unknown). on electron microscopy, immunotactoid glomerulopathy is characterized by the formation of microtubules which are much larger than the fibrils observed in fibrillary glomerulonephritis (30 to 50 versus 16 to 24 nm in diameter). the signs and symptoms include blood (hematuria) and protein (proteinuria) in the urine, kidney insufficiency and high blood pressure. both fibrillary glomerulonephritis and immunotactoid glomerulopathy have been associated with hepatitis c virus infection and with malignancy and autoimmune disease. also, patients with immunotactoid glomerulopathy have a greater risk to have chronic lymphocytic leukemia and b cell lymphomas and should be screened for all of these conditions. treatment is generally determined by the severity of the kidney problems. last updated: 8/18/2015

MalaCards based summary: Immunotactoid Glomerulopathy, also known as immunotactoid glomerulonephritis, is related to immunotactoid or fibrillary glomerulopathy and fibrillary glomerulonephritis. An important gene associated with Immunotactoid Glomerulopathy is ALB (Albumin). Affiliated tissues include b cells, kidney and bone.

Related Diseases for Immunotactoid Glomerulopathy

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Graphical network of the top 20 diseases related to Immunotactoid Glomerulopathy:



Diseases related to immunotactoid glomerulopathy

Symptoms for Immunotactoid Glomerulopathy

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Drugs & Therapeutics for Immunotactoid Glomerulopathy

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Drugs for Immunotactoid Glomerulopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Immunologic FactorsPhase 218483
3Antirheumatic AgentsPhase 28496

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot Study of Rituximab to Treat Fibrillary GlomerulonephritisActive, not recruitingNCT02197767Phase 2

Search NIH Clinical Center for Immunotactoid Glomerulopathy

Genetic Tests for Immunotactoid Glomerulopathy

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Anatomical Context for Immunotactoid Glomerulopathy

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MalaCards organs/tissues related to Immunotactoid Glomerulopathy:

33
B cells, Kidney, Bone, Liver, Monocytes, Lung, T cells

Animal Models for Immunotactoid Glomerulopathy or affiliated genes

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Publications for Immunotactoid Glomerulopathy

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Articles related to Immunotactoid Glomerulopathy:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermalA necrolysis in adults 2016 (print summary - Full guidelines available at http://dx.doi.org/10.1016/j.bjps.2016.01.034). (27216885)
2016
2
EPHB4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcoma. (25274141)
2014
3
Riociguat for pulmonary hypertension. (24304056)
2013
4
Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. (23633195)
2013
5
The potential for functional recovery of upper extremity function following cervical spinal cord injury without major bone injury. (24042986)
2013
6
HDAC4 controls histone methylation in response to elevated cardiac load. (23434587)
2013
7
Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. (23152559)
2012
8
Dampness and moulds in workplace buildings: associations with incidence and remission of sick building syndrome (SBS) and biomarkers of inflammation in a 10 year follow-up study. (22634552)
2012
9
Hyaline vascular type of unicentric Castleman's disease with proliferation of glomerular endothelial cells. (23211339)
2012
10
Board-invited review: St. Anthony's Fire in livestock: causes, mechanisms, and potential solutions. (21521821)
2011
11
Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report. (21210329)
2010
12
Thrombin-cleaved osteopontin is increased in urine of patients with rheumatoid arthritis. (20156944)
2010
13
Abundance of plasma cells in a case of lipodermatosclerosis. (20361885)
2010
14
Selective immunoglobulin M deficiency presenting with recurrent impetigo: a case report and review of the literature. (19218822)
2009
15
A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime. (19675583)
2009
16
Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain. (19158275)
2009
17
HSPA1A is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1. (17471537)
2007
18
The incidence of clozapine-induced leukopenia in patients with schizophrenia at Srinagarind Hospital. (18041439)
2007
19
Abeta40 inhibits amyloid deposition in vivo. (17234594)
2007
20
Identification of binding proteins to the PDZ domain of ERBIN]. (17633453)
2007
21
Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer]. (16615267)
2006
22
APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency. (16531747)
2006
23
The H19 gene: regulation and function of a non-coding RNA. (16575179)
2006
24
Treatment of precocious puberty in two patients with Turner mosaicism. (16200850)
2005
25
Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations. (15941723)
2005
26
Ultrasound diagnosis of fetal macrosomia: a comparison of weight prediction models using computer simulation. (16180258)
2005
27
Inducing effect of cyclosporin A on apoptosis of multidrug resistant cell lines HR20 and HT9]. (15601549)
2004
28
Pseudoperoxidase activity of myoglobin: kinetics and mechanism of the peroxidase cycle of myoglobin with H2O2 and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonate) as substrates. (12952438)
2003
29
A novel role for dp115 in the organization of tER sites in Drosophila. (12876273)
2003
30
Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells. (11823046)
2002
31
High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology. (12703061)
2002
32
Metallothionein isogene transcription in red blood cell precursors from human cord blood. (11168427)
2001
33
Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy. (11595348)
2001
34
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. (11055499)
2000
35
Regulation of the antioxidant response element by protein kinase C- mediated phosphorylation of NF-E2-related factor 2. (11035812)
2000
36
A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif. (10660557)
2000
37
Plasma constituents regulate LPS binding to, and release from, the monocyte cell surface. (11521074)
2000
38
Serum cytokines and increased total serum IgE in alcoholics. (10437818)
1999
39
An aged male patient with autoimmune hepatitis complicated by hepatocellular carcinoma. (10397080)
1999
40
Papillary adenocarcinoma of the lung: radiologic and pathologic findings. (10050820)
1999
41
Mulibrey nanism and Wilms tumor. (10377015)
1999
42
Miliary tuberculosis. (9682716)
1998
43
Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity. (9840744)
1998
44
Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. (9737236)
1998
45
Effect of pharmaceutical care on optimum colestipol treatment in elderly hypercholesterolemic veterans. (9165562)
1997
46
Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells. (8746951)
1995
47
Ultraviolet-induced p53 mutations in atypical fibroxanthoma. (8030743)
1994
48
Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway. (8486647)
1993
49
Abnormal growth hormone and dwarfism. (4040212)
1985
50

Variations for Immunotactoid Glomerulopathy

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Expression for genes affiliated with Immunotactoid Glomerulopathy

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Search GEO for disease gene expression data for Immunotactoid Glomerulopathy.

Pathways for genes affiliated with Immunotactoid Glomerulopathy

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GO Terms for genes affiliated with Immunotactoid Glomerulopathy

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Sources for Immunotactoid Glomerulopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet