MCID: IMM053
MIFTS: 21

Immunotactoid Glomerulopathy malady

Rare diseases, Nephrological diseases, Immune diseases categories

Aliases & Classifications for Immunotactoid Glomerulopathy

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Sources:
65UMLS, 45NIH Rare Diseases, 51Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Immunotactoid Glomerulopathy:

Name: Immunotactoid Glomerulopathy 45 51
 
Fibrillary Glomerulonephritis 65


Classifications:

Orphanet: 51 
Rare renal diseases


External Ids:

Orphanet51 97567
ICD10 via Orphanet28 N03.6

Summaries for Immunotactoid Glomerulopathy

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NIH Rare Diseases:45 Immunotactoid glomerulopathy, also known as glomerulonephritis with organized monoclonal microtubular immunoglobulin deposits (gommid),  is a very uncommon cause of glomerular disease. it is related to a similar disease known as fibrillary glomerulopathy, which is more common. both disorders probably result from deposits derived from immunoglobulins, but in most cases the cause is idiopathic (unknown). on electron microscopy, immunotactoid glomerulopathy is characterized by the formation of microtubules which are much larger than the fibrils observed in fibrillary glomerulonephritis (30 to 50 versus 16 to 24 nm in diameter). the signs and symptoms include blood (hematuria) and protein (proteinuria) in the urine, kidney insufficiency and high blood pressure. both fibrillary glomerulonephritis and immunotactoid glomerulopathy have been associated with hepatitis c virus infection and with malignancy and autoimmune disease. also, patients with immunotactoid glomerulopathy have a greater risk to have chronic lymphocytic leukemia and b cell lymphomas and should be screened for all of these conditions. treatment is generally determined by the severity of the kidney problems. last updated: 8/18/2015

MalaCards based summary: Immunotactoid Glomerulopathy, also known as fibrillary glomerulonephritis, is related to fibrillary glomerulonephritis and immunotactoid or fibrillary glomerulopathy. An important gene associated with Immunotactoid Glomerulopathy is ALB (Albumin). Affiliated tissues include kidney, b cells and bone.

Related Diseases for Immunotactoid Glomerulopathy

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Diseases related to Immunotactoid Glomerulopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1fibrillary glomerulonephritis10.7
2immunotactoid or fibrillary glomerulopathy10.7
3glomerulonephritis10.7
4vasculitis10.4
5hodgkin lymphoma10.3
6sickle cell anemia10.3
7chronic lymphocytic leukemia10.3
8hepatitis10.3
9leukemia10.3
10liver disease10.3
11mycosis fungoides10.3
12hepatitis c10.3
13down syndrome10.3
14amyloidosis10.3
15glomerulosclerosis10.3
16heavy chain disease10.3
17kidney disease10.3
18nephrotic syndrome10.3
19tuberculosis10.3
20hypereosinophilic syndrome10.3
21cytomegalovirus infection10.3

Graphical network of the top 20 diseases related to Immunotactoid Glomerulopathy:



Diseases related to immunotactoid glomerulopathy

Symptoms for Immunotactoid Glomerulopathy

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Drugs & Therapeutics for Immunotactoid Glomerulopathy

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Drugs for Immunotactoid Glomerulopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot Study of Rituximab to Treat Fibrillary GlomerulonephritisRecruitingNCT02197767Phase 2

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Genetic Tests for Immunotactoid Glomerulopathy

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Anatomical Context for Immunotactoid Glomerulopathy

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MalaCards organs/tissues related to Immunotactoid Glomerulopathy:

33
Kidney, B cells, Bone, Skin, Liver, Bone marrow

Animal Models for Immunotactoid Glomerulopathy or affiliated genes

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Publications for Immunotactoid Glomerulopathy

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Articles related to Immunotactoid Glomerulopathy:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases. (26418732)
2015
2
AJKD Atlas of Renal Pathology: Immunotactoid Glomerulopathy. (26408243)
2015
3
Immunotactoid Glomerulopathy and Cryoglobulinemic Nephropathy: Two Entities with Many Similarities. A Unified Conceptual Approach. (26270724)
2015
4
Laser microdissection and proteomic analysis of amyloidosis, cryoglobulinemic GN, fibrillary GN, and immunotactoid glomerulopathy. (23411427)
2013
5
Immunotactoid glomerulopathy: clinicopathologic and proteomic study. (22872726)
2012
6
Chronic lymphocytic leukemia associated with immunotactoid glomerulopathy: a case report of successful treatment with high-dose methylprednisolone in combination with rituximab followed by alemtuzumab. (22335532)
2012
7
Immunotactoid glomerulopathy and tuberculosis: a novel association. (21629347)
2011
8
Spontaneous remission of immunotactoid glomerulopathy. (21934180)
2011
9
A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy. (19367362)
2009
10
A case of recurrent immunotactoid glomerulopathy in an allograft treated with rituximab. (19917422)
2009
11
A case of immunotactoid glomerulopathy with rapid progression to end-stage renal disease. (20024509)
2009
12
Plasma cell dyscrasia; LCDD vs Immunotactoid glomerulopathy. (18711301)
2008
13
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. (18045849)
2008
14
Long-term remission of paraprotein-induced immunotactoid glomerulopathy after high-dose therapy and autologous blood stem cell transplantation. (17605010)
2007
15
Immunotactoid glomerulopathy with microtubular deposits, with reference to the characteristics of Japanese cases. (15909596)
2005
16
A 59-year-old woman with immunotactoid glomerulopathy, heavy-chain disease, and non-hodgkin lymphoma. (15163227)
2004
17
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. (15299095)
2004
18
Immunotactoid glomerulopathy in an HIV-positive African-American man. (14655225)
2003
19
Images in cardiovascular medicine. Fibrillary/immunotactoid glomerulopathy with cardiac involvement. (11956134)
2002
20
Immunotactoid glomerulopathy. (11961029)
2002
21
Immunotactoid glomerulopathy in sickle cell anemia. (11198611)
2001
22
Immunotactoid glomerulopathy characterized by steroid-responsive massive subendothelial deposition. (11228198)
2001
23
Immunotactoid glomerulopathy with massive bone marrow deposits in a patient with IgM kappa monoclonal gammopathy and hypocomplementemia. (11479168)
2001
24
One case of immunotactoid glomerulopathy: morphological-ultrastructural aspects. (11846092)
2001
25
Successful treatment of recurrence of immunotactoid glomerulopathy in a kidney allograft recipient. (10831649)
2000
26
Fibrillary-immunotactoid glomerulopathy with renal deposits of IgAlambda: a rare cause of glomerulonephritis. (10604647)
1999
27
Immunotactoid glomerulopathy--an unusual deposition disease: report of the first Malaysian case. (10879280)
1999
28
Immunotactoid glomerulopathy associated with idiopathic hypereosinophilic syndrome. (9653841)
1998
29
A case of immunotactoid glomerulopathy with unusual microtubular deposits. (9617498)
1998
30
Hepatitis C viral infection is associated with fibrillary glomerulonephritis and immunotactoid glomerulopathy. (9848778)
1998
31
Successful treatment with steroid pulse therapy in a case of immunotactoid glomerulopathy with hypocomplementemia. (10074587)
1998
32
Immunotactoid glomerulopathy: report of a case. (9214417)
1997
33
Immunotactoid glomerulopathy with extrarenal deposits in the bone, and chronic cholestatic liver disease. (8856222)
1996
34
Immunotactoid glomerulopathy with unusually thick extracellular microtubules and nodular glomerulosclerosis in a diabetic patient. (7479381)
1995
35
De novo immunotactoid glomerulopathy of the renal allograft: possible association with cytomegalovirus infection. (8023832)
1994
36
Morphologic and clinical features of fibrillary glomerulonephritis versus immunotactoid glomerulopathy. (8372831)
1993
37
Immunotactoid glomerulopathy: the case for Occam's razor. (8372842)
1993
38
Fibrillary glomerulonephritis and immunotactoid glomerulopathy: two entities, not one. (8372843)
1993
39
Immunotactoid glomerulopathy (ITGP): a not fully defined clinicopathologic entity. (8516498)
1993
40
Immunotactoid glomerulopathy in a child with Down syndrome. (8439490)
1993
41
Immunotactoid glomerulopathy. (1496977)
1992
42
Fibrillary (immunotactoid) glomerulopathy. A possible role for kappa light chain in its etiology and/or pathogenesis. (1905497)
1991
43
Immunotactoid glomerulopathy and cutaneous vasculitis. (1904680)
1991
44
Nonamyloidotic fibrillary glomerulopathy, immunotactoid glomerulopathy, and the differential diagnosis of filamentous glomerulopathies. (2020659)
1991
45
Immunotactoid glomerulopathy. (1996564)
1991
46
Course of renal transplantation in immunotactoid glomerulopathy. (2368797)
1990
47
Immunotactoid glomerulopathy associated with mycosis fungoides. (2235815)
1990
48
Immunotactoid glomerulopathy with fingerprint immune deposits. A variant of lupus nephritis? (2500773)
1989
49
Immunotactoid glomerulopathy with leucocytoclastic skin vasculitis and hypocomplementemia: a case report. (3552344)
1987
50
Immunotactoid glomerulopathy. (4010500)
1985

Variations for Immunotactoid Glomerulopathy

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Expression for genes affiliated with Immunotactoid Glomerulopathy

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Search GEO for disease gene expression data for Immunotactoid Glomerulopathy.

Pathways for genes affiliated with Immunotactoid Glomerulopathy

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GO Terms for genes affiliated with Immunotactoid Glomerulopathy

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Sources for Immunotactoid Glomerulopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet