MCID: IMM053
MIFTS: 22

Immunotactoid Glomerulopathy malady

Categories: Rare diseases, Nephrological diseases, Immune diseases

Aliases & Classifications for Immunotactoid Glomerulopathy

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Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Immunotactoid Glomerulopathy:

Name: Immunotactoid Glomerulopathy 48 54
Immunotactoid Glomerulonephritis 48 54
 
Fibrillary Glomerulonephritis 68

Characteristics:

Orphanet epidemiological data:

54
immunotactoid glomerulonephritis:
Inheritance: Not applicable; Age of onset: Adult

Classifications:

Orphanet: 54 
Rare renal diseases


External Ids:

Orphanet54 ORPHA97567
ICD10 via Orphanet31 N03.6

Summaries for Immunotactoid Glomerulopathy

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NIH Rare Diseases:48 Immunotactoid glomerulopathy, also known as glomerulonephritis with organized monoclonal microtubular immunoglobulin deposits (gommid),  is a very uncommon cause of glomerular disease. it is related to a similar disease known as fibrillary glomerulopathy, which is more common. both disorders probably result from deposits derived from immunoglobulins, but in most cases the cause is idiopathic (unknown). on electron microscopy, immunotactoid glomerulopathy is characterized by the formation of microtubules which are much larger than the fibrils observed in fibrillary glomerulonephritis (30 to 50 versus 16 to 24 nm in diameter). the signs and symptoms include blood (hematuria) and protein (proteinuria) in the urine, kidney insufficiency and high blood pressure. both fibrillary glomerulonephritis and immunotactoid glomerulopathy have been associated with hepatitis c virus infection and with malignancy and autoimmune disease. also, patients with immunotactoid glomerulopathy have a greater risk to have chronic lymphocytic leukemia and b cell lymphomas and should be screened for all of these conditions. treatment is generally determined by the severity of the kidney problems. last updated: 8/18/2015

MalaCards based summary: Immunotactoid Glomerulopathy, also known as immunotactoid glomerulonephritis, is related to immunotactoid or fibrillary glomerulopathy and fibrillary glomerulonephritis. An important gene associated with Immunotactoid Glomerulopathy is ALB (Albumin). Affiliated tissues include kidney, b cells and bone.

Related Diseases for Immunotactoid Glomerulopathy

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Graphical network of the top 20 diseases related to Immunotactoid Glomerulopathy:



Diseases related to immunotactoid glomerulopathy

Symptoms & Phenotypes for Immunotactoid Glomerulopathy

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Drugs & Therapeutics for Immunotactoid Glomerulopathy

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Drugs for Immunotactoid Glomerulopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 210956

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot Study of Rituximab to Treat Fibrillary GlomerulonephritisActive, not recruitingNCT02197767Phase 2

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Genetic Tests for Immunotactoid Glomerulopathy

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Anatomical Context for Immunotactoid Glomerulopathy

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MalaCards organs/tissues related to Immunotactoid Glomerulopathy:

36
Kidney, B cells, Bone, Skin, Liver, Bone marrow

Publications for Immunotactoid Glomerulopathy

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Articles related to Immunotactoid Glomerulopathy:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Immunotactoid glomerulopathy with IGM positivity and associated IGM paraprotein. (27772927)
2016
2
A case report of unusually long lag time between immunotactoid glomerulopathy (itg) diagnosis and diffuse large B-cell lymphoma (DLBCL) development. (27686684)
2016
3
End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases. (26418732)
2015
4
Immunotactoid Glomerulopathy and Cryoglobulinemic Nephropathy: Two Entities with Many Similarities. A Unified Conceptual Approach. (26270724)
2015
5
AJKD Atlas of Renal Pathology: Immunotactoid Glomerulopathy. (26408243)
2015
6
Laser microdissection and proteomic analysis of amyloidosis, cryoglobulinemic GN, fibrillary GN, and immunotactoid glomerulopathy. (23411427)
2013
7
Chronic lymphocytic leukemia associated with immunotactoid glomerulopathy: a case report of successful treatment with high-dose methylprednisolone in combination with rituximab followed by alemtuzumab. (22335532)
2012
8
Immunotactoid glomerulopathy: clinicopathologic and proteomic study. (22872726)
2012
9
Immunotactoid glomerulopathy and tuberculosis: a novel association. (21629347)
2011
10
Spontaneous remission of immunotactoid glomerulopathy. (21934180)
2011
11
A case of recurrent immunotactoid glomerulopathy in an allograft treated with rituximab. (19917422)
2009
12
A case of immunotactoid glomerulopathy with rapid progression to end-stage renal disease. (20024509)
2009
13
A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy. (19367362)
2009
14
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. (18045849)
2008
15
Plasma cell dyscrasia; LCDD vs Immunotactoid glomerulopathy. (18711301)
2008
16
Long-term remission of paraprotein-induced immunotactoid glomerulopathy after high-dose therapy and autologous blood stem cell transplantation. (17605010)
2007
17
Immunotactoid glomerulopathy with microtubular deposits, with reference to the characteristics of Japanese cases. (15909596)
2005
18
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. (15299095)
2004
19
A 59-year-old woman with immunotactoid glomerulopathy, heavy-chain disease, and non-hodgkin lymphoma. (15163227)
2004
20
Immunotactoid glomerulopathy in an HIV-positive African-American man. (14655225)
2003
21
Images in cardiovascular medicine. Fibrillary/immunotactoid glomerulopathy with cardiac involvement. (11956134)
2002
22
Immunotactoid glomerulopathy. (11961029)
2002
23
One case of immunotactoid glomerulopathy: morphological-ultrastructural aspects. (11846092)
2001
24
Immunotactoid glomerulopathy characterized by steroid-responsive massive subendothelial deposition. (11228198)
2001
25
Immunotactoid glomerulopathy in sickle cell anemia. (11198611)
2001
26
Immunotactoid glomerulopathy with massive bone marrow deposits in a patient with IgM kappa monoclonal gammopathy and hypocomplementemia. (11479168)
2001
27
Successful treatment of recurrence of immunotactoid glomerulopathy in a kidney allograft recipient. (10831649)
2000
28
Fibrillary-immunotactoid glomerulopathy with renal deposits of IgAlambda: a rare cause of glomerulonephritis. (10604647)
1999
29
Immunotactoid glomerulopathy--an unusual deposition disease: report of the first Malaysian case. (10879280)
1999
30
Successful treatment with steroid pulse therapy in a case of immunotactoid glomerulopathy with hypocomplementemia. (10074587)
1998
31
A case of immunotactoid glomerulopathy with unusual microtubular deposits. (9617498)
1998
32
Immunotactoid glomerulopathy associated with idiopathic hypereosinophilic syndrome. (9653841)
1998
33
Hepatitis C viral infection is associated with fibrillary glomerulonephritis and immunotactoid glomerulopathy. (9848778)
1998
34
Immunotactoid glomerulopathy: report of a case. (9214417)
1997
35
Immunotactoid glomerulopathy with extrarenal deposits in the bone, and chronic cholestatic liver disease. (8856222)
1996
36
Clinical features, predictors of disease progression and results of renal transplantation in fibrillary/immunotactoid glomerulopathy. (8671905)
1996
37
Immunotactoid glomerulopathy with unusually thick extracellular microtubules and nodular glomerulosclerosis in a diabetic patient. (7479381)
1995
38
De novo immunotactoid glomerulopathy of the renal allograft: possible association with cytomegalovirus infection. (8023832)
1994
39
Immunotactoid glomerulopathy (ITGP): a not fully defined clinicopathologic entity. (8516498)
1993
40
Immunotactoid glomerulopathy: the case for Occam's razor. (8372842)
1993
41
Immunotactoid glomerulopathy in a child with Down syndrome. (8439490)
1993
42
Fibrillary glomerulonephritis and immunotactoid glomerulopathy: two entities, not one. (8372843)
1993
43
Morphologic and clinical features of fibrillary glomerulonephritis versus immunotactoid glomerulopathy. (8372831)
1993
44
Immunotactoid glomerulopathy. (1496977)
1992
45
Immunotactoid glomerulopathy. (1996564)
1991
46
Fibrillary (immunotactoid) glomerulopathy. A possible role for kappa light chain in its etiology and/or pathogenesis. (1905497)
1991
47
Nonamyloidotic fibrillary glomerulopathy, immunotactoid glomerulopathy, and the differential diagnosis of filamentous glomerulopathies. (2020659)
1991
48
Immunotactoid glomerulopathy and cutaneous vasculitis. (1904680)
1991
49
Immunotactoid glomerulopathy associated with mycosis fungoides. (2235815)
1990
50
Course of renal transplantation in immunotactoid glomerulopathy. (2368797)
1990

Variations for Immunotactoid Glomerulopathy

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Expression for genes affiliated with Immunotactoid Glomerulopathy

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Search GEO for disease gene expression data for Immunotactoid Glomerulopathy.

Pathways for genes affiliated with Immunotactoid Glomerulopathy

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GO Terms for genes affiliated with Immunotactoid Glomerulopathy

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Sources for Immunotactoid Glomerulopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet