MCID: IMP004
MIFTS: 45

Impetigo malady

Skin diseases category

Summaries for Impetigo

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards: Impetigo, also known as impetigo nos, is related to dermatitis and pemphigus. An important gene associated with Impetigo is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Apoptotic cleavage of cell adhesion proteins. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype mortality/aging.

Disease Ontology:8 Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous.

Wikipedia:63 Impetigo /ɪmpɨˈtaɪɡoʊ/ is a highly contagious bacterial skin infection most common among... more...

Aliases & Classifications for Impetigo

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

impetigo 8 10 33 60
impetigo nos 8


External Ids:

Disease Ontology8 DOID:8504
MeSH34 D007169
ICD9CM27 684
ICD1025 L01, L01.0

Related Diseases for Impetigo

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impetigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.6DSG3, DSG1
2pemphigus30.5DSG2, DSG1, DSG4, DSG3
3glomerulonephritis30.5EDNRB
4bullous impetigo30.4EDNRA, DSG1, EDNRB
5ritter's disease30.1EDNRB, EDNRA, DSG1
6bullous skin disease30.0DSG3, DSG1
7acute poststreptococcal glomerulonephritis30.0SKA2, EDNRB, SKA1
8toxic shock syndrome29.8EDNRA, SPEG
9impetigo herpetiformis10.8
10atopic dermatitis10.3
11psoriasis10.3
12pharyngitis10.2
13hypoparathyroidism10.2
14miliaria10.2
15miliaria rubra10.1
16ecthyma10.1
17herpes simplex10.1
18pyoderma10.1
19scabies10.1
20carbuncle10.0
21alopecia10.0
22conjunctivitis10.0
23dermatitis herpetiformis10.0
24skin disease10.0
25scarlet fever10.0EDNRA
26netherton syndrome10.0DSG1
27pemphigus vegetans10.0DSG1
28keratoacanthoma10.0DSG3
29subcorneal pustular dermatosis10.0DSG1
30erysipelas10.0PI3
31hepatopulmonary syndrome10.0EDNRB
32tonsillitis10.0EDNRA, HSF4
33exfoliation syndrome10.0EDNRB, EDNRA
34cystic kidney10.0EDNRB, EDNRA
35epidermolysis bullosa acquisita10.0DSG1
36impotence10.0EDNRB, EDNRA
37pemphigus foliaceus10.0DSG2, DSG3, DSG1
38pemphigus vulgaris10.0DSG3, DSG1, DSG2, DSG4
39mucoepidermoid carcinoma10.0SUMF2, AGR3, NR4A1
40squamous cell carcinoma10.0DSG2, DSG1, PI3, EDNRB, DSG3
41hypertrophic scars9.9
42diaper rash9.9
43intrahepatic cholestasis9.9
44chronic granulomatous disease9.9
45cellulitis9.9
46systemic lupus erythematosus9.9
47immune-complex glomerulonephritis9.9
48rickets9.9
49pyomyositis9.9
50chickenpox9.9

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to impetigo

Clinical Features for Impetigo

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Drugs & Therapeutics for Impetigo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Impetigo

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Anatomical Context for Impetigo

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32MalaCards
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MalaCards organs/tissues related to Impetigo:

32
Skin

Animal Models for Impetigo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Impetigo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6SPEG, EDNRB, EDNRA, NR4A1, DSG4, DSG3

Publications for Impetigo

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50PubMed
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Articles related to Impetigo:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Impetigo-like tinea faciei around the nostrils caused by Arthroderma vanbreuseghemii identified using polymerase chain reaction-based sequencing of crusts. (23278484)
2013
2
Treatment of impetigo: oral antibiotics most commonly prescribed. (22453587)
2012
3
Streptococcus pyogenes pharyngitis & impetigo in a rural area of Panchkula district in Haryana, India. (22382196)
2012
4
Fusidic acid-resistant Staphylococcus aureus in impetigo contagiosa and secondarily infected atopic dermatitis. (20107726)
2010
5
Identifying impetigo. Interview by Lynne Pearce. (19186629)
2009
6
Molecular studies of an impetigo bullosa epidemic in full-term infants. (19252410)
2009
7
Chickenpox, impetigo, and anetoderma. (16780492)
2006
8
Impetigo herpetiformis--a rare dermatosis of pregnancy associated with prenatal complications. (16284679)
2005
9
Desmosomes and disease: pemphigus and bullous impetigo. (15363804)
2004
10
Interventions for impetigo. (15106198)
2004
11
FactSheet: boils and impetigo. (12732916)
2003
12
Impetigo herpetiformis followed by generalized pustular psoriasis: more evidence of same disease entity. (12956698)
2003
13
Impetigo: an update. (12694487)
2003
14
Recurrent impetigo herpetiformis in a pregnant adolescent: case report. (11858900)
2002
15
Humanized in vivo model for streptococcal impetigo. (10768985)
2000
16
Isolation of Staphylococcus chromogenes from an unusual case of impetigo in a goat. (9194303)
1997
17
Microbiology of nonbullous impetigo. (9192410)
1997
18
Review of mupirocin ointment in the treatment of impetigo. (1468173)
1992
19
Impetigo and its treatment. (3600454)
1987
20
Impetigo herpetiformis and pustular psoriasis during pregnancy. (6625114)
1983
21
Re-emergence of bullous impetigo. (6799136)
1982
22
Bullous impetigo caused by Streptococcus salivarius: a case report. (7002959)
1980
23
The epidermolytic toxin of Staphylococcus aureus: its failure to bind to cells and its detection in blister fluids of patients with bullous impetigo. (701847)
1978
24
Streptococcal types in impetigo and acute glomerulonephritis among children in Addis Ababa. (788141)
1976
25
Letter: Impetigo neonatorum congenita due to group B beta-hemolytic streptococcus infection. (1127538)
1975
26
Microscopic features of pustule formation in experimental impetigo of guinea pig. (4470720)
1974
27
Skin complications of heroin addiction. Bullous impetigo. (4513637)
1973
28
Natural history of impetigo. I. Site sequence of acquisition and familial patterns of spread of cutaneous streptococci. (5080412)
1972
29
A hamster model for streptococcal impetigo. (5449492)
1970
30
Bullous impetigo due to group II Staphylococcus aureus. An epidemic in a normal newborn nursery. (5422851)
1970
31
Impetigo contagiosa: suppurative and non-suppurative complications. I. Clinical, bacteriologic, and epidemiologic characteristics of impetigo. (4868792)
1968
32
THE BACTERIOLOGIC FINDINGS, STREPTOCOCCAL IMMUNE RESPONSE, AND RENAL COMPLICATIONS IN CHILDREN AND IMPETIGO. (14258652)
1965
33
Impetigo in the Waikato. (4221564)
1965
34
The route of antibiotic administration in superficial impetigo. (14017141)
1963
35
Further observations on the bacteriology of impetigo and pemphigus neonatorum. (13732854)
1961
36
A note on the treatment of impetigo contagiosa. (13475969)
1957
37
Impetigo; a suggested rAcgime to decrease its assessed morbidity. (13417186)
1957
38
The treatment of impetigo. (13322803)
1956
39
Impetigo contagiosa; the association of certain types of Staphylococcus aureus and of Streptococcus pyogenes with superficial skin infections. (13278531)
1955
40
Impetigo. (12984226)
1952
41
On impetigo herpetiformis. (14822640)
1951
42
Acute glomerulonephritis: impetigo as an etiological factor; a review of 124 cases at Lloyd Noland Hospital, Fairfield, Ala. (14825043)
1951
43
The etiology of poral closure; an experimental study of miliaria rubra, bullous impetigo and related diseases of the skin. I. An historical review of the causation of miliaria. (15437051)
1950
44
Comments to "The etiology of poral closure, an experimental study of miliaria rubra, bullous impetigo and related diseases of the skin. By John P. O'Brien, M. D.". (15437055)
1950
45
Treatment of impetigo at a tropical base. (20995467)
1946
46
Treatment of Impetigo. (20786076)
1945
47
Impetigo Contagiosa, its Epidemiology and Control. (20475258)
1935
48
THE CARE AND PREVENTION OF IMPETIGO NEONATORUM. (20319762)
1935
49
Cicatricial Alopecia following Impetigo of Scalp. (19988983)
1932
50
Bullous Purpura following Impetigo. (19973963)
1909

Genetic Variations for Impetigo

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Expression for genes affiliated with Impetigo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for genes affiliated with Impetigo

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53Reactome
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Pathways related to Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8DSG2, DSG1, DSG3
29.8DSG2, DSG1, DSG3

Compounds for genes affiliated with Impetigo

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Impetigo according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1[125i]et-12810.4EDNRA, EDNRB
2pd 1450654410.4EDNRB, EDNRA
3sitaxsentan44 2811.4EDNRB, EDNRA
4pd 1428934410.4EDNRB, EDNRA
5bq6104410.4EDNRB, EDNRA
6bq 302044 2811.4EDNRB, EDNRA
7ambrisentan44 2811.4EDNRB, EDNRA
8irl 162044 2811.4EDNRA, EDNRB
9tezosentan4410.4EDNRA, EDNRB
10Sitaxentan1110.3EDNRA, EDNRB
11fr13931744 2811.3EDNRB, EDNRA
12sarafotoxin4410.3EDNRB, EDNRA
13atrasentan4410.3EDNRB, EDNRA
14darusentan44 2811.2EDNRB, EDNRA
15bq78844 2811.2EDNRB, EDNRA
16bq12344 2811.2EDNRA, EDNRB
17bosentan44 1111.1EDNRA, EDNRB
18toxin a4410.0DSG1, DSG3, EDNRA, EDNRB
19acetylcholine44 49 28 11 2413.6EDNRB, EDNRA, DSG3, DSG1
20cyclosporin a44 28 5911.5NR4A1, PI3, EDNRA, EDNRB
21calcium44 49 11 2411.3EDNRB, EDNRA, PI3, NR4A1, DSG4, DSG3

GO Terms for genes affiliated with Impetigo

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16Gene Ontology
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Cellular components related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:0009409.8SKA1, SKA2
2desmosomeGO:0300579.3DSG2, DSG1, DSG3, DSG4

Biological processes related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:05067810.1EDNRB, EDNRA
2enteric nervous system developmentGO:04848410.1EDNRA, EDNRB
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.9DSG2, DSG1, DSG3
4vasoconstrictionGO:0423109.8EDNRA, EDNRB
5regulation of microtubule polymerization or depolymerizationGO:0311109.7SKA2, SKA1
6homophilic cell adhesionGO:0071569.7DSG2, DSG1, DSG3, DSG4

Molecular functions related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:00496210.1EDNRA, EDNRB

Products for genes affiliated with Impetigo

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Impetigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet