MCID: IMP004
MIFTS: 49

Impetigo malady

Skin diseases category
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Summaries for Impetigo

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MedlinePlus:33 Impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards based summary: Impetigo is related to bullous impetigo and pemphigus vegetans. An important gene associated with Impetigo is DSG1 (desmoglein 1), and among its related pathways are Prostaglandin Synthesis and Regulation and Endothelin. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and hematopoietic system.

Disease Ontology:8 A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous.

Wikipedia:65 Impetigo /?mp??ta??o?/ is a highly contagious bacterial skin infection most common among pre-school... more...

Aliases & Classifications for Impetigo

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Impetigo, Aliases & Descriptions:

Name: Impetigo 8 10 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:8504
MeSH34 D007169
ICD9CM27 684
ICD1025 L01, L01.0

Related Diseases for Impetigo

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Diseases related to Impetigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1bullous impetigo31.6EDNRB, DSG1, EDNRA
2pemphigus vegetans30.9DSG1
3dermatitis30.8CD79A, DSG3, DSG1
4ritter's disease30.7DSG1, EDNRA, EDNRB
5glomerulonephritis30.5CD79A, EDNRB, CD40LG
6pemphigus30.4DSG3, DSG4, DSG1, CD79A
7pemphigus foliaceus30.2DSG1, CD79A, DSG3
8acute poststreptococcal glomerulonephritis30.2SKA2, CD79A, EDNRB
9hypertension29.9EDNRB, CD79A, EDNRA
10meningitis29.8CD79A, SUMF2
11pneumonia29.6EDNRA, SUMF2, CD79A, PI3
12impetigo herpetiformis10.9
13netherton syndrome10.5DSG1
14erysipelas10.5PI3
15hepatopulmonary syndrome10.5EDNRB
16exfoliation syndrome10.4EDNRA, EDNRB
17bullous skin disease10.4DSG1, DSG3
18cystic kidney10.4EDNRB, EDNRA
19atopic dermatitis10.4
20impotence10.4EDNRB, EDNRA
21psoriasis10.3
22q fever10.3CD79A
23polycystic kidney disease, autosomal dominant10.3EDNRB, EDNRA
24syphilis10.3CD79A
25pharyngitis10.3
26blindness10.3
27macroglobulinemia10.3CD79A
28cryptosporidiosis10.3CD79A
29sinusitis10.2CD79A
30hypoparathyroidism10.2
31miliaria10.2
32pemphigus vulgaris10.2DSG4, DSG1, DSG3
33pulmonary hypertension10.2EDNRB, EDNRA
34subcorneal pustular dermatosis10.2DSG1, CD79A
35ecthyma10.2
36miliaria rubra10.2
37herpes simplex10.2
38pyoderma10.2
39scabies10.2
40generalized pustular psoriasis10.2
41systemic scleroderma10.2EDNRB, CD40LG, EDNRA
42epidermolysis bullosa acquisita10.1CD79A, DSG1
43tonsillitis10.1CD79A, EDNRA
44mucoepidermoid carcinoma10.1SUMF2, NR4A1
45congenital toxoplasmosis10.1CD79A, CD40LG
46immunoglobulin g deficiency10.1CD79A, CD40LG
47connective tissue disease10.1CD40LG, CD79A
48alopecia10.1
49carbuncle10.1
50conjunctivitis10.1

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to impetigo

Symptoms for Impetigo

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Drugs & Therapeutics for Impetigo

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Drug clinical trials:

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Genetic Tests for Impetigo

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Anatomical Context for Impetigo

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MalaCards organs/tissues related to Impetigo:

32
Skin

Animal Models for Impetigo or affiliated genes

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MGI Mouse Phenotypes related to Impetigo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5CD40LG, NR4A1, DSG3, DSG4, EDNRB
2MP:00053977.3EDNRA, DSG4, DSG3, FARSA, NR4A1, CD79A
3MP:00107687.2EDNRB, EDNRA, DSG4, DSG3, FARSA, NR4A1
4MP:00053877.2CD40LG, EDNRB, EDNRA, DSG4, DSG3, FARSA

Publications for Impetigo

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Articles related to Impetigo:

(show top 50)    (show all 425)
idTitleAuthorsYear
1
Clinical inquiry: what is the best treatment for impetigo ? (25061625)
2014
2
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. (25298068)
2014
3
Treatment of impetigo in resource-limited settings. (25172375)
2014
4
Outbreak of bullous impetigo caused by Staphylococcus aureus strains of phage type 3C/71 in a maternity ward linked to nasal carriage of a healthcare worker. (22378195)
2012
5
Treatment of impetigo: oral antibiotics most commonly prescribed. (22453587)
2012
6
Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient. (22677026)
2012
7
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. (22696729)
2011
8
Trimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial. (20415992)
2010
9
Topical therapies for impetigo. (20216288)
2010
10
Retapamulin for impetigo and other infections. (18832258)
2008
11
Efficacy and safety of retapamulin ointment as treatment of impetigo: randomized double-blind multicentre placebo-controlled trial. (18341664)
2008
12
Information from your family doctor. Impetigo: what you should know. (17390598)
2007
13
Diagnosis and treatment of impetigo. (17390597)
2007
14
Is blistering distal dactylitis a variant of bullous impetigo? (17362240)
2007
15
A retrospective study of some clinical and epidemiological features of impetigo patients seen in dermatology clinic in the eastern province of saudi arabia. (23012100)
2006
16
Methotrexate treatment of recurrent impetigo herpetiformis with hypoparathyroidism. (16836512)
2006
17
Topical antibiotic treatment of impetigo with tetracycline. (16361729)
2005
18
Current options for the treatment of impetigo in children. (16218885)
2005
19
Impetigo herpetiformis--a rare dermatosis of pregnancy associated with prenatal complications. (16284679)
2005
20
Antimicrobial resistance of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000. (12581136)
2003
21
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. (12093888)
2002
22
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. (11062541)
2000
23
Paediatric dermatology. Impetigo. (9735496)
1998
24
Streptococcal impetigo among aboriginal children in Malaysia. (9139400)
1995
25
Twin sisters with impetigo herpetiformis. (8903778)
1995
26
Double-blind study comparing erythromycin and mupirocin for treatment of impetigo in children: implications of a high prevalence of erythromycin-resistant Staphylococcus aureus strains. (1605593)
1992
27
Impetigo. (1899777)
1991
28
Increasing the antibiotic spectrum in the treatment of impetigo. (2305732)
1990
29
Two sisters with impetigo herpetiformis. (2805396)
1989
30
Diagnosis and treatment of impetigo. (2913075)
1989
31
Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole. (3069760)
1988
32
Impetigo contagiosa: a comparison of erythromycin and dicloxacillin therapy. (3045781)
1988
33
Bullous impetigo and localized scalded skin syndrome in the elderly. (3623889)
1987
34
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
35
Topical antibiotic treatment of impetigo with mupirocin. (3096221)
1986
36
What histologic finding distinguishes superficial pemphigus and bullous impetigo? (6375421)
1984
37
Some aspects of impetigo herpetiformis. (7059209)
1982
38
Sequential bullous impetigo and cutaneous Herpes simplex virus infection. (6761658)
1982
39
A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. (7028065)
1981
40
Bullous impetigo caused by Streptococcus salivarius: a case report. (7002959)
1980
41
Letter: Telephoners' impetigo. (952547)
1976
42
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
43
Impetigo herpetiformis in two successive pregnancies. (4286099)
1966
44
Three cases of acute nephritis occurring simultaneously in a family following impetigo contagiosa. (14392361)
1955
45
Impetigo and acute infectious exfoliative dermatitis of the newborn infant (Ritter's disease). (14955740)
1952
46
On impetigo herpetiformis. (14822640)
1951
47
Chronic symmetric impetigo. (18110559)
1949
48
Impetigo Herpetiformis.A ? Pemphigus Vegetans. (20917911)
1947
49
Impetigo bullosa in the tropics. (21065466)
1945
50
Bullous Purpura following Impetigo. (19973963)
1909

Variations for Impetigo

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Expression for genes affiliated with Impetigo

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Expression patterns in normal tissues for genes affiliated with Impetigo

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Pathways for genes affiliated with Impetigo

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Pathways related to Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EDNRA, EDNRB
29.9EDNRA, EDNRB
39.9EDNRA, EDNRB
4
Show member pathways
9.8DSG3, DSG1
59.7CD79A, CD40LG

Compounds for genes affiliated with Impetigo

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Compounds related to Impetigo according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1[125i]et-12810.3EDNRA, EDNRB
2pd 1450654410.3EDNRB, EDNRA
3sitaxsentan44 2811.3EDNRA, EDNRB
4bq6104410.3EDNRB, EDNRA
5ambrisentan44 2811.3EDNRA, EDNRB
6pd 1428934410.3EDNRB, EDNRA
7bq 302044 2811.3EDNRB, EDNRA
8atrasentan4410.3EDNRB, EDNRA
9irl 162044 2811.3EDNRB, EDNRA
10sarafotoxin4410.3EDNRA, EDNRB
11darusentan44 2811.3EDNRB, EDNRA
12fr13931744 2811.3EDNRA, EDNRB
13tezosentan4410.3EDNRB, EDNRA
14bq78844 2811.2EDNRA, EDNRB
15bq12344 2811.2EDNRA, EDNRB
16bosentan44 1111.2EDNRB, EDNRA
17sulfolipid i4410.1CD79A, CD40LG
18sandoglobulin4410.1CD79A, CD40LG
19gamma globulin4410.0CD79A, CD40LG
20vancomycin44 1110.9CD40LG, CD79A
21pneumococcal449.9CD79A, CD40LG
22blys449.9CD40LG, CD79A
23sulfonamide449.9EDNRB, EDNRA
24tuberculin449.9CD79A, CD40LG
25praziquantel44 1110.8CD79A, CD40LG
26hemocyanin449.8CD40LG, CD79A
27rituximab44 50 1111.8CD40LG, CD79A, DSG1
28gliadin449.8CD79A, CD40LG
29prednisolone44 28 1111.6EDNRA, CD79A, DSG3
30toxin a449.6EDNRB, DSG3, DSG1, EDNRA
31pmma449.6CD79A, CD40LG
32formaldehyde44 2410.6EDNRA, CD40LG, CD79A
33indomethacin44 28 61 1112.5EDNRA, CD40LG, CD79A, EDNRB
34norepinephrine44 24 1111.5EDNRB, EDNRA, CD79A, CD40LG
35pge2449.4EDNRB, CD79A, EDNRA, CD40LG
36histamine44 28 2411.4CD79A, EDNRA, PI3, CD40LG
37ivig449.4CD40LG, DSG1, DSG3, CD79A
38silicone449.4CD79A, CD40LG
39dopamine44 28 24 1112.2EDNRA, NR4A1, CD40LG, CD79A
40steroid449.1EDNRA, PI3, CD79A, NR4A1, EDNRB
41vegf448.9EDNRB, CD40LG, EDNRA, NR4A1, CD79A
42alanine448.9CD40LG, CD79A, NR4A1, EDNRA, EDNRB
43testosterone44 61 24 1111.9CD79A, CD40LG, NR4A1, EDNRA
44acetylcholine44 50 28 24 1112.8EDNRA, EDNRB, DSG1, CD79A, DSG3, CD40LG
45retinoic acid44 249.7PI3, NR4A1, CD79A, CD40LG, EDNRB, DSG1
46cyclosporin a44 28 6110.7EDNRA, NR4A1, CD79A, CD40LG, PI3, EDNRB
47dexamethasone44 50 28 1111.7CD40LG, NR4A1, EDNRB, PI3, CD79A, EDNRA
48cysteine448.7CD40LG, CD79A, NR4A1, PI3, EDNRA, EDNRB
49calcium44 50 24 1111.4PI3, DSG4, DSG1, DSG3, NR4A1, EDNRA
50serine448.4DSG1, EDNRB, EDNRA, PI3, DSG3, NR4A1

GO Terms for genes affiliated with Impetigo

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Cellular components related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.1DSG3, DSG1, DSG4
2plasma membraneGO:0058868.0EDNRA, DSG4, DSG1, DSG3, CD79A, CD40LG

Biological processes related to Impetigo according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:05067810.0EDNRA, EDNRB
2vasoconstrictionGO:04231010.0EDNRA, EDNRB
3enteric nervous system developmentGO:0484849.9EDNRB, EDNRA
4sensory perception of painGO:0192339.9EDNRA, EDNRB
5B cell proliferationGO:0421009.6CD40LG, CD79A
6homophilic cell adhesionGO:0071569.5DSG3, DSG1, DSG4
7cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG3, DSG1

Molecular functions related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.9EDNRA, EDNRB

Products for genes affiliated with Impetigo

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Sources for Impetigo

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
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