Aliases & Classifications for Impetigo

MalaCards integrated aliases for Impetigo:

Name: Impetigo 12 72 40 3 41 14 69 59

Classifications:



External Ids:

Disease Ontology 12 DOID:8504
ICD10 32 L01 L01.0 L01.00
ICD9CM 34 684
MeSH 41 D007169
NCIt 46 C99088
UMLS 69 C0021099

Summaries for Impetigo

MedlinePlus : 40 Impetigo is a skin infection caused by bacteria. It is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. It is most common in children between the ages of two and six. It usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. Symptoms start with red or pimple-like sores surrounded by red skin. These sores can be anywhere, but usually they occur on your face, arms and legs. The sores fill with pus, then break open after a few days and form a thick crust. They are often itchy, but scratching them can spread the sores. Impetigo can spread by contact with sores or nasal discharge from an infected person. You can treat impetigo with antibiotics. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Impetigo is related to impetigo herpetiformis and bullous impetigo, and has symptoms including pruritus, fever and exanthema. An important gene associated with Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Lung fibrosis and amb2 Integrin signaling. The drugs Fusidic Acid and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and colon.

Disease Ontology : 12 A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

CDC : 3 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

PubMed Health : 59
About impetigo: Impetigo is an itchy and sometimes painful infection of the outer layers of skin that is especially common in young children. It is caused by bacteria and is highly contagious. For that reason, children who have impetigo are not allowed to return to school or day care until they are no longer contagious – about 24 hours after the start of treatment with antibiotics. Without treatment, it can remain contagious for several weeks.

Wikipedia : 72 Impetigo is a bacterial infection that involves the superficial skin. The most common presentation is... more...

Related Diseases for Impetigo

Diseases related to Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 impetigo herpetiformis 33.6 ELANE IL36RN PI3
2 bullous impetigo 32.9 CALCA DSG1 EDNRB IL6
3 ritter's disease 31.5 DSG1 EDNRB HSF4
4 necrotizing fasciitis 31.2 IL6 MYOM2
5 scarlet fever 31.0 EDNRB MYOM2
6 pustular psoriasis 30.1 ELANE IL36RN PI3
7 psoriasis 29.7 ELANE IL36RN IL6 PI3
8 streptococcal toxic-shock syndrome 29.4 IL6 MYOM2
9 erysipelas 29.3 CALCA ELANE PI3
10 toxic shock syndrome 29.0 IL6 MYOM2
11 pyoderma 11.4
12 ecthyma 11.2
13 prolidase deficiency 10.9
14 acute proliferative glomerulonephritis 10.9
15 subcorneal pustular dermatosis 10.3 DSG1 IL36RN
16 pasteurellosis 10.3 ELANE PI3
17 farmer's lung 10.3 ELANE PI3
18 pustulosis palmaris et plantaris 10.2 ELANE IL36RN
19 engraftment syndrome 10.2 CALCA PI3
20 capillary leak syndrome 10.2 ELANE IL6
21 dermatitis 10.2
22 osteitis fibrosa 10.2 CALCA IL6
23 scabies 10.2
24 extrinsic allergic alveolitis 10.2 IL6 PI3
25 gingival disease 10.2 ELANE IL6
26 pemphigus 10.2
27 esophagitis 10.2 DSG1 IL6
28 glomerulonephritis 10.1
29 pulmonary disease, chronic obstructive 10.1 ELANE IL6
30 vulvitis 10.1 ELANE HSF4
31 nodular goiter 10.1 CALCA IL6
32 complex regional pain syndrome 10.1 CALCA IL6
33 adult respiratory distress syndrome 10.1 ELANE IL6
34 dermatitis, atopic 10.1
35 chorioamnionitis 10.1 ELANE IL6
36 bone resorption disease 10.1 CALCA IL6
37 gingivitis 10.1 ELANE IL6
38 pustulosis of palm and sole 10.1
39 netherton syndrome 10.0 DSG1 ELANE PI3
40 pharyngitis 10.0
41 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 ELANE IL6
42 multiple endocrine neoplasia, type iib 10.0 CALCA EDNRB
43 autonomic nervous system disease 10.0 CALCA EDNRB
44 acute respiratory distress syndrome 10.0 ELANE IL6 PI3
45 polyclonal hypergammaglobulinemia 10.0 IL6 MYOM2
46 poems syndrome 10.0 IL6 MYOM2
47 osteosclerotic myeloma 10.0 IL6 MYOM2
48 hypoparathyroidism 9.9
49 miliaria 9.9
50 cellulitis 9.9

Comorbidity relations with Impetigo via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to Impetigo

Symptoms & Phenotypes for Impetigo

UMLS symptoms related to Impetigo:


pruritus, fever, exanthema

Drugs & Therapeutics for Impetigo

PubMedHealth treatment related to Impetigo: 59

As long as impetigo doesn't spread beyond a small patch of skin, disinfectant solutions or creams are often recommended. But it isn't clear whether they work.Antibiotic creams have proven effective. Antibiotics that are swallowed (oral antibiotics) are usually only prescribed if a child has impetigo on a large area of skin or if several parts of their body are affected. Antibiotic tablets are more likely to have side effects than antibiotic creams. For instance, they may cause gastrointestinal (stomach and bowel) problems.Good hygiene is the key to avoiding infection, especiallywashing hands frequently,not sharing towels, andwashing worn clothing at 60°C (140°F) or higher.It's a good idea to keep the child’s fingernails trimmed very short so they can't scratch themselves as much.

Drugs for Impetigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fusidic Acid Approved, Investigational Phase 4,Phase 3 6990-06-3 3000226
2
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 46936176 6474909
3
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
4
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antiparasitic Agents Phase 4
8
Mupirocin Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 12650-69-0 446596
9
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
10
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
11
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
12 Respiratory System Agents Phase 2, Phase 3
13 Terpin Phase 2, Phase 3
14 Dermatologic Agents Phase 2, Phase 3
15 Expectorants Phase 2, Phase 3
16 Antipruritics Phase 2, Phase 3
17 methicillin Phase 3
18 Micronutrients Phase 3
19 Trace Elements Phase 3
20 Antibiotics, Antitubercular Phase 3,Phase 2
21
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
22 Papaya Approved, Nutraceutical Phase 1
23
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
24
Albendazole Approved, Vet_approved 54965-21-8 2082
25 Vaccines
26 Anthelmintics
27 Antimitotic Agents
28 Liver Extracts
29 Lipoxygenase Inhibitors
30 Antiprotozoal Agents

Interventional clinical trials:

(show all 28)

# Name Status NCT ID Phase Drugs
1 Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection Completed NCT01126268 Phase 4 Retapamulin (Altabax)
2 Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections. Completed NCT00555061 Phase 4 Retapamulin Ointment, 1%
3 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
4 Fucidin® Cream in the Treatment of Impetigo Terminated NCT00986856 Phase 4 Fucidin® cream
5 Citriodiol® and Impetigo Unknown status NCT01611909 Phase 2, Phase 3 p-menthane-3,8-diol oil
6 Treatment Of Impetigo With Topical SB-275833 Ointment, 1% Versus Topical Placebo Ointment Completed NCT00133848 Phase 3 SB-275833 ointment, 1%
7 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
8 Vehicle Controlled Efficacy and Safety Study of Two Dose Regimens of CD07223 1.5% Topical Gel in Impetigo Completed NCT01670032 Phase 2, Phase 3 Experimental: CD07223 1.5 % Topical Gel BID;Experimental: CD07223 1.5% Topical Gel TID;Placebo Comparator: CD07223 vehicle gel BID;Placebo Comparator: CD07223 vehicle gel TID
9 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream
10 Topical SB-275833 Ointment, 1% For The Treatment Of Impetigo Completed NCT00133874 Phase 3 SB-275833 ointment, 1%
11 Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA Completed NCT00852540 Phase 3 Retpamulin Ointment, 1%;Linezolid
12 Immunological and Clinical Responses to Zinc in Children With Diarrhoea Completed NCT00408356 Phase 3 Zinc
13 Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Impetigo Patients Completed NCT01171326 Phase 2 Topical Minocycline Foam FXFM244
14 A Phase II Study to Evaluate the Efficacy and Safety of Two Doses of LTX-109 in Impetigo Completed NCT01803035 Phase 2 LTX-109 1 %;LTX-109 2 %;Placebo gel
15 The Pharmacokinetics of 2% TD1414 Cream in Adults With Secondarily Infected Traumatic Lesions (SITL) or Impetigo Completed NCT00758862 Phase 2 2% TD1414 Cream
16 Safety and Efficacy of Topical NVC-422 Gel in Impetigo Completed NCT01367314 Phase 2 NVC-422
17 Efficacy, Safety, and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL) Completed NCT00626795 Phase 2 TD1414 2% cream;TD1414 2% cream;Bactroban® (mupirocin) 2% cream
18 A Study to Evaluate Safety, Tolerability and Efficacy of Lytixar™ (LTX-109) on Uncomplicated, Gram-positive, Skin Infection Completed NCT01223222 Phase 2 LTX-109
19 Study Evaluating the Safety, Tolerability, PK, and Activity of Topical ATx201 Gel in Outpatients With Impetigo Not yet recruiting NCT03429595 Phase 2 ATx201
20 The Efficacy and Safety of Topical Papaya (Carica Papaya) Leaf Extract 1% Ointment Versus Mupirocin 2% Ointment in the Treatment of Limited Impetigo: a Randomized, Double-blind, Controlled Clinical Trial Unknown status NCT01943136 Phase 1 papaya 1% extract ointment;mupirocin 2% ointment
21 EU PV for Retapamulin-Prescribing Completed NCT01153828 Retapamulin;Co-prescription of retapamulin and topical mupirocin;Co-prescription of retapamulin and topical fusidic acid
22 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
23 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
24 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276
25 United States Pharmacovigilence Retapamulin-Prescribing Completed NCT01153880 Retapamulin;Co-prescription of retapamulin and topical mupirocin
26 ALTARGO(Retapamulin) PMS(Post-marketing Surveillance) Completed NCT01445600 ALTARGO(retapamulin)
27 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
28 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822

Search NIH Clinical Center for Impetigo

Cochrane evidence based reviews: impetigo

Genetic Tests for Impetigo

Anatomical Context for Impetigo

MalaCards organs/tissues related to Impetigo:

38
Skin, Eye, Colon, Liver, Monocytes, Neutrophil, T Cells

Publications for Impetigo

Articles related to Impetigo:

(show top 50) (show all 477)
# Title Authors Year
1
Impetigo: A need for new therapies in a world of increasing antimicrobial resistance. ( 29063621 )
2018
2
Granulocyte/Monocyte Adsorption Apheresis as a Novel Therapeutic Approach in the Treatment of an Impetigo Herpetiformis Case. ( 29318775 )
2018
3
Building capacity in primary care: the implementation of a novel 'Pharmacy First' scheme for the management of UTI, impetigo and COPD exacerbation. ( 29362007 )
2018
4
The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial. ( 28722612 )
2017
5
Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections. ( 28671945 )
2017
6
Diagnosis and management of impetigo. ( 28178083 )
2017
7
Bullous impetigo during interstitial pneumonitis. ( 29050448 )
2017
8
Incremental Contributions of FbaA and Other Impetigo-Associated Surface Proteins to Fitness and Virulence of a Classical Group A Streptococcal Skin Strain. ( 28808160 )
2017
9
Management of impetigo and cellulitis: Simple considerations for promoting appropriate antibiotic use in skin infections. ( 28807958 )
2017
10
Community-Based Prescribing for Impetigo in Remote Australia: An Opportunity for Antimicrobial Stewardship. ( 28748178 )
2017
11
Recurrent impetigo herpetiformis: case report. ( 28979621 )
2017
12
Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. ( 28270312 )
2017
13
Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. ( 28579477 )
2017
14
Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess. ( 29255730 )
2017
15
Impetigo ( 28613693 )
2017
16
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
17
Tissue tropisms in group A Streptococcus: what virulence factors distinguish pharyngitis from impetigo strains? ( 26895573 )
2016
18
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. ( 27617460 )
2016
19
Impetigo and scabies - Disease burden and modern treatment strategies. ( 27180311 )
2016
20
Where to from here? The treatment of impetigo in children as resistance to fusidic acid emerges. ( 27736855 )
2016
21
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
22
A Case of Tinea Corporis due to Trichophyton tonsurans that Manifested as Impetigo. ( 27581776 )
2016
23
Staphylococcal bullous impetigo in a neonate. ( 27458596 )
2016
24
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. ( 27573023 )
2016
25
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
26
Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings. ( 27659511 )
2016
27
"EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern. ( 26821848 )
2016
28
Topical Minocycline Foam for the Treatment of Impetigo in Children: Results of a Randomized, Double-Blind, Phase 2 Study. ( 27741342 )
2016
29
Crusted impetigo-like lesion on the face: a case of IgG/IgA pemphigus. ( 27879012 )
2016
30
Staphylococcus aureus penetrate the interkeratinocyte spaces created by skin-infiltrating neutrophils in a mouse model of impetigo. ( 27862501 )
2016
31
The Importance of Scabies Coinfection in the Treatment Considerations for Impetigo. ( 26599569 )
2016
32
Impetigo contagiosa in a zosteriform pattern. ( 27333861 )
2016
33
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. ( 27599660 )
2016
34
An association between newly diagnosed cutaneous T cell lymphoma and prior impetigo: a nested case-control study. ( 27613059 )
2016
35
The Prevalence of Scabies and Impetigo in the Solomon Islands: A Population-Based Survey. ( 27348119 )
2016
36
Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo. ( 25876581 )
2015
37
Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae ) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. ( 25855021 )
2015
38
Fabric-skin models to assess infection transfer for impetigo contagiosa in a kindergarten scenario. ( 25666081 )
2015
39
Prevalence of scabies and impetigo worldwide: a systematic review. ( 26088526 )
2015
40
Impetigo contagiosa with Nikolsky sign in adult patient of advanced malignant melanoma. ( 26173486 )
2015
41
Scabies and impetigo prevalence and risk factors in Fiji: a national survey. ( 25738499 )
2015
42
Photodynamic Antibacterial Enhanced Effect Of Methylene Blue-Gold Nanoparticles Conjugate On Staph Aureus Isolated From Impetigo Lesions In Vitro Study. ( 25827622 )
2015
43
The Global Epidemiology of Impetigo: A Systematic Review of the Population Prevalence of Impetigo and Pyoderma. ( 26317533 )
2015
44
Zosteriform impetigo: Wolf's isotopic response in a cutaneous immunocompromised district. ( 26336623 )
2015
45
Allergic Contact Dermatitis to Benzoyl Peroxide Resembling Impetigo. ( 25782705 )
2015
46
Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus. ( 26135320 )
2015
47
Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. ( 26104679 )
2015
48
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014
49
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis. ( 25413895 )
2014
50
A Randomized, Double-blind, Comparative Study to Assess the Safety and Efficacy of Topical Retapamulin Ointment 1% Versus Oral Linezolid in the Treatment of Secondarily Infected Traumatic Lesions and Impetigo Due to Methicillin-Resistant Staphylococcus aureus. ( 25396674 )
2014

Variations for Impetigo

Expression for Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for Impetigo

Pathways related to Impetigo according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.06 CALCA IL6
2 10.84 ELANE IL6
3 10.61 CALCA IL6
4 10.15 CALCA EDNRB

GO Terms for Impetigo

Cellular components related to Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 DSG1 PI3

Biological processes related to Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.43 CALCA EDNRB
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.4 ELANE IL6
3 antimicrobial humoral response GO:0019730 9.37 ELANE PI3
4 monocyte chemotaxis GO:0002548 9.32 CALCA IL6
5 vasodilation GO:0042311 9.26 CALCA EDNRB
6 response to pain GO:0048265 9.16 CALCA EDNRB
7 negative regulation of bone resorption GO:0045779 8.96 CALCA IL6
8 negative regulation of chemokine biosynthetic process GO:0045079 8.62 ELANE IL6

Sources for Impetigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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