MCID: IMP004
MIFTS: 45

Impetigo malady

Skin diseases category

Summaries for Impetigo

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards: Impetigo, also known as impetigo nos, is related to dermatitis and pemphigus. An important gene associated with Impetigo is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Apoptotic cleavage of cell adhesion proteins. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype mortality/aging.

Disease Ontology:8 Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous.

Wikipedia:63 Impetigo /ɪmpɨˈtaɪɡoʊ/ is a highly contagious bacterial skin infection most common among... more...

Aliases & Classifications for Impetigo

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

impetigo 8 10 33 60
impetigo nos 8


External Ids:

Disease Ontology8 DOID:8504
MeSH34 D007169
ICD9CM27 684
ICD1025 L01, L01.0

Related Diseases for Impetigo

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impetigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.6DSG3, DSG1
2pemphigus30.5DSG2, DSG1, DSG4, DSG3
3glomerulonephritis30.5EDNRB
4bullous impetigo30.4EDNRA, DSG1, EDNRB
5ritter's disease30.1EDNRB, EDNRA, DSG1
6bullous skin disease30.0DSG3, DSG1
7acute poststreptococcal glomerulonephritis30.0SKA2, EDNRB, SKA1
8toxic shock syndrome29.8EDNRA, SPEG
9impetigo herpetiformis10.8
10atopic dermatitis10.3
11psoriasis10.3
12pharyngitis10.2
13hypoparathyroidism10.2
14miliaria10.2
15miliaria rubra10.1
16ecthyma10.1
17herpes simplex10.1
18pyoderma10.1
19scabies10.1
20carbuncle10.0
21alopecia10.0
22conjunctivitis10.0
23dermatitis herpetiformis10.0
24skin disease10.0
25scarlet fever10.0EDNRA
26netherton syndrome10.0DSG1
27pemphigus vegetans10.0DSG1
28keratoacanthoma10.0DSG3
29subcorneal pustular dermatosis10.0DSG1
30erysipelas10.0PI3
31hepatopulmonary syndrome10.0EDNRB
32tonsillitis10.0EDNRA, HSF4
33exfoliation syndrome10.0EDNRB, EDNRA
34cystic kidney10.0EDNRB, EDNRA
35epidermolysis bullosa acquisita10.0DSG1
36impotence10.0EDNRB, EDNRA
37pemphigus foliaceus10.0DSG2, DSG3, DSG1
38pemphigus vulgaris10.0DSG3, DSG1, DSG2, DSG4
39mucoepidermoid carcinoma10.0SUMF2, AGR3, NR4A1
40squamous cell carcinoma10.0DSG2, DSG1, PI3, EDNRB, DSG3
41hypertrophic scars9.9
42diaper rash9.9
43intrahepatic cholestasis9.9
44chronic granulomatous disease9.9
45cellulitis9.9
46systemic lupus erythematosus9.9
47immune-complex glomerulonephritis9.9
48rickets9.9
49pyomyositis9.9
50chickenpox9.9

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to impetigo

Clinical Features for Impetigo

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Drugs & Therapeutics for Impetigo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Impetigo

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Anatomical Context for Impetigo

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32MalaCards
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MalaCards organs/tissues related to Impetigo:

32
Skin

Animal Models for Impetigo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Impetigo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6SPEG, EDNRB, EDNRA, NR4A1, DSG4, DSG3

Publications for Impetigo

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50PubMed
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Articles related to Impetigo:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Recurrent postpartum impetigo herpetiformis presenting after a "skip" pregnancy. (22854922)
2013
2
Spread of the epidemic European fusidic acid-resistant impetigo clone (EEFIC) in general practice patients in the south of The Netherlands. (22290345)
2012
3
Interventions for impetigo. (22258953)
2012
4
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. (22696729)
2011
5
Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan. (22187567)
2011
6
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. (17065642)
2006
7
Impetigo herpetiformis. (16487882)
2006
8
A case of impetigo herpetiformis associated with intrahepatic cholestasis of pregnancy. (16923139)
2006
9
Current options for the treatment of impetigo in children. (16218885)
2005
10
Seasonal occurrence of impetigo: a retrospective 8-year review (1996-2003). (16045681)
2005
11
Impetigo in soldiers after hand-to-hand combat training. (16450826)
2005
12
Treatment of impetigo: paint it blue. (15499130)
2004
13
Treatment of bullous impetigo and the staphylococcal scalded skin syndrome in infants. (15482208)
2004
14
Clinicopathological case 3: pemphigus foliaceus; bullous impetigo; subcorneal pustular dermatoses. (12823325)
2003
15
Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigo. (12480897)
2002
16
Fusidic acid cream for impetigo. Findings cannot be extrapolated. (12053931)
2002
17
Staphylococcus aureus isolated in cases of impetigo produces both epidermolysin A or B and LukE-LukD in 78% of 131 retrospective and prospective cases. (11724844)
2001
18
Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. (10461035)
1999
19
Streptococcal impetigo induces Th1-preponderant activation of T lymphocytes with subsequent anergy to superantigenic exotoxins in patients with atopic dermatitis. (9602892)
1998
20
Extremely low levels of epidermal skin-derived antileucoproteinase/elafin in a patient with impetigo herpetiformis. (9274639)
1997
21
Twins with impetigo herpetiformis. (8850053)
1996
22
Bullous impetigo caused by group A streptococci. A case report. (1350146)
1992
23
A bacteriologically controlled, randomized study comparing the efficacy of 2% mupirocin ointment (Bactroban) with oral erythromycin in the treatment of patients with impetigo. (2112166)
1990
24
Impetigo contagiosa III. Comparative efficacy of oral erythromycin and topical mupirocin. (2501775)
1989
25
Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo. (3149884)
1988
26
Group A streptococcal pharyngeal carriage and impetigo in two northern native communities. (3078513)
1988
27
Prescribing antibiotics for impetigo. (3056694)
1988
28
Some aspects of impetigo herpetiformis. (7059209)
1982
29
Impetigo herpetiformis with lowered serum level of vitamin D and its diminished intestinal absorption. (7095227)
1982
30
A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. (7028065)
1981
31
Orthotic collar in the treatment of intertriginous impetigo. (940849)
1976
32
Predisposing factors of the skin surface in persons with impetigo contagiosa. (1200716)
1975
33
New approach to the therapy of Bockhart's impetigo by electrodesiccation. (4547739)
1974
34
Response of impetigo herpetiformis to ampicillin. (5038609)
1972
35
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
36
Impetigo contagiosa in children. (5779210)
1969
37
Impetigo contagiosa: etiology, complications, and comparison of therapeutic effectiveness of erythromycin and antibiotic ointment. (4290285)
1967
38
SOME SKIN CONDITIONS: ECZEMA AND IMPETIGO CONTAGIOSA. (14156185)
1964
39
Boils, carbuncles and impetigo. (13844889)
1960
40
Impetigo herpetiformis in conjunction with parathyroprival tetany. (13478426)
1957
41
Clinical and bacteriological aspects of impetigo contagiosa. (13278534)
1955
42
Chronic vesicular impetigo of the trunk (two cases). (14869607)
1951
43
The etiology of poral closure. II. The role of staphylococcal infection in miliaria rubra and bullous impetigo. (15437052)
1950
44
Impetigo contagiosa treated parenterally with penicillin-beeswax. (20289533)
1947
45
Penicillin in impetigo contagiosum. (20279872)
1946
46
Medical research in physical education; impetigo scabies and cutaneous manifestations of malnutrition. (21012159)
1946
47
Impetigo bullosa in the tropics. (21065466)
1945
48
Impetigo Treated with Sodium Penicillin Cream. (20785884)
1945
49
Some Considerations Regarding the Etiology of Impetigo Contagiosa. (18746295)
1942
50
Case of Impetigo of Bockhart of Unusual Extent and Severity. (19979969)
1918

Genetic Variations for Impetigo

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Expression for genes affiliated with Impetigo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for genes affiliated with Impetigo

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53Reactome
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Pathways related to Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8DSG2, DSG1, DSG3
29.8DSG2, DSG1, DSG3

Compounds for genes affiliated with Impetigo

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Impetigo according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1[125i]et-12810.4EDNRA, EDNRB
2pd 1450654410.4EDNRB, EDNRA
3sitaxsentan44 2811.4EDNRB, EDNRA
4pd 1428934410.4EDNRB, EDNRA
5bq6104410.4EDNRB, EDNRA
6bq 302044 2811.4EDNRB, EDNRA
7ambrisentan44 2811.4EDNRB, EDNRA
8irl 162044 2811.4EDNRA, EDNRB
9tezosentan4410.4EDNRA, EDNRB
10Sitaxentan1110.3EDNRA, EDNRB
11fr13931744 2811.3EDNRB, EDNRA
12sarafotoxin4410.3EDNRB, EDNRA
13atrasentan4410.3EDNRB, EDNRA
14darusentan44 2811.2EDNRB, EDNRA
15bq78844 2811.2EDNRB, EDNRA
16bq12344 2811.2EDNRA, EDNRB
17bosentan44 1111.1EDNRA, EDNRB
18toxin a4410.0DSG1, DSG3, EDNRA, EDNRB
19acetylcholine44 49 28 11 2413.6EDNRB, EDNRA, DSG3, DSG1
20cyclosporin a44 28 5911.5NR4A1, PI3, EDNRA, EDNRB
21calcium44 49 11 2411.3EDNRB, EDNRA, PI3, NR4A1, DSG4, DSG3

GO Terms for genes affiliated with Impetigo

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16Gene Ontology
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Cellular components related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:0009409.8SKA1, SKA2
2desmosomeGO:0300579.3DSG2, DSG1, DSG3, DSG4

Biological processes related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:05067810.1EDNRA, EDNRB
2enteric nervous system developmentGO:04848410.1EDNRA, EDNRB
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.9DSG2, DSG1, DSG3
4vasoconstrictionGO:0423109.8EDNRA, EDNRB
5regulation of microtubule polymerization or depolymerizationGO:0311109.7SKA2, SKA1
6homophilic cell adhesionGO:0071569.7DSG2, DSG1, DSG3, DSG4

Molecular functions related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:00496210.1EDNRA, EDNRB

Products for genes affiliated with Impetigo

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Impetigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet