MCID: IMP004
MIFTS: 51

Impetigo malady

Skin diseases category

Summaries for Impetigo

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9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards: Impetigo, also known as impetigo nos, is related to bullous impetigo and dermatitis. An important gene associated with Impetigo is DSG1 (desmoglein 1), and among its related pathways are Prostaglandin Synthesis and Regulation and Endothelin. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin and eye, and related mouse phenotypes are integument and hematopoietic system.

Disease Ontology:9 Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous.

CDC:4 Group A Streptococcus (group A strep, GAS) bacteria can live in a person's nose and throat. The bacteria are spread through contact with droplets from an infected person's cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill. If you drink from the same glass or eat from the same plate as the sick person, you could also become ill. It is also possible for group A strep bacteria to spread from contact with sores from a group A strep skin infection. More

Wikipedia:66 Impetigo /?mp??ta??o?/ is a highly contagious bacterial skin infection most common among pre-school... more...

Aliases & Classifications for Impetigo

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9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

impetigo 9 11 35 63
impetigo nos 9


External Ids:

Disease Ontology9 DOID:8504
ICD9CM28 684
MeSH36 D007169
ICD1026 L01, L01.0

Related Diseases for Impetigo

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Impetigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1bullous impetigo31.3DSG1, EDNRA, EDNRB
2dermatitis30.7CD79A, DSG3, DSG1
3pemphigus30.6DSG4, DSG1, DSG3, CD79A
4glomerulonephritis30.6EDNRB, CD79A, CD40LG
5ritter's disease30.3DSG1, EDNRA, EDNRB
6pemphigus vegetans30.3DSG1
7pemphigus foliaceus30.1DSG1, DSG3, CD79A
8acute poststreptococcal glomerulonephritis30.1CD79A, SKA2, EDNRB
9hypertension29.9EDNRB, EDNRA, CD79A
10meningitis29.8SUMF2, CD79A
11pneumonia29.8EDNRA, PI3, SUMF2, CD79A
12impetigo herpetiformis10.9
13atopic dermatitis10.3
14psoriasis10.3
15pharyngitis10.3
16hypoparathyroidism10.2
17miliaria10.2
18blindness10.2
19ecthyma10.2
20miliaria rubra10.2
21herpes simplex10.2
22pyoderma10.2
23scabies10.2
24generalized pustular psoriasis10.2
25netherton syndrome10.1DSG1
26erysipelas10.1PI3
27hepatopulmonary syndrome10.1EDNRB
28exfoliation syndrome10.1EDNRB, EDNRA
29bullous skin disease10.1DSG3, DSG1
30cystic kidney10.1EDNRA, EDNRB
31impotence10.1EDNRB, EDNRA
32q fever10.1CD79A
33polycystic kidney disease, autosomal dominant10.1EDNRB, EDNRA
34syphilis10.1CD79A
35alopecia10.1
36conjunctivitis10.1
37dermatitis herpetiformis10.1
38exfoliative dermatitis10.1
39nephritis10.1
40superficial pemphigus10.1
41macroglobulinemia10.1CD79A
42cryptosporidiosis10.1CD79A
43sinusitis10.1CD79A
44pemphigus vulgaris10.1DSG4, DSG1, DSG3
45primary pulmonary hypertension10.0EDNRA, EDNRB
46subcorneal pustular dermatosis10.0CD79A, DSG1
47systemic scleroderma10.0EDNRB, EDNRA, CD40LG
48epidermolysis bullosa acquisita10.0DSG1, CD79A
49tonsillitis10.0EDNRA, CD79A
50mucoepidermoid carcinoma10.0NR4A1, SUMF2

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to impetigo

Symptoms for Impetigo

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Drugs & Therapeutics for Impetigo

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Impetigo

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Anatomical Context for Impetigo

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34MalaCards
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MalaCards organs/tissues related to Impetigo:

34
Skin, Eye

Animal Models for Impetigo or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Impetigo:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5CD40LG, NR4A1, DSG3, DSG4, EDNRB
2MP:00053977.3EDNRA, DSG4, DSG3, FARSA, NR4A1, CD79A
3MP:00107687.2EDNRB, EDNRA, DSG4, DSG3, FARSA, NR4A1
4MP:00053877.2CD40LG, EDNRB, EDNRA, DSG4, DSG3, FARSA

Publications for Impetigo

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Sources:
53PubMed
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Articles related to Impetigo:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Outbreak of bullous impetigo caused by Staphylococcus aureus strains of phage type 3C/71 in a maternity ward linked to nasal carriage of a healthcare worker. (22378195)
2012
2
Treatment of impetigo: oral antibiotics most commonly prescribed. (22453587)
2012
3
Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient. (22677026)
2012
4
First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. (22696729)
2011
5
Trimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial. (20415992)
2010
6
Topical therapies for impetigo. (20216288)
2010
7
Retapamulin for impetigo and other infections. (18832258)
2008
8
Efficacy and safety of retapamulin ointment as treatment of impetigo: randomized double-blind multicentre placebo-controlled trial. (18341664)
2008
9
Information from your family doctor. Impetigo: what you should know. (17390598)
2007
10
Diagnosis and treatment of impetigo. (17390597)
2007
11
Is blistering distal dactylitis a variant of bullous impetigo? (17362240)
2007
12
A retrospective study of some clinical and epidemiological features of impetigo patients seen in dermatology clinic in the eastern province of saudi arabia. (23012100)
2006
13
Methotrexate treatment of recurrent impetigo herpetiformis with hypoparathyroidism. (16836512)
2006
14
Topical antibiotic treatment of impetigo with tetracycline. (16361729)
2005
15
Current options for the treatment of impetigo in children. (16218885)
2005
16
Impetigo herpetiformis--a rare dermatosis of pregnancy associated with prenatal complications. (16284679)
2005
17
Antimicrobial resistance of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000. (12581136)
2003
18
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. (12093888)
2002
19
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. (11062541)
2000
20
Paediatric dermatology. Impetigo. (9735496)
1998
21
Isolation of Staphylococcus chromogenes from an unusual case of impetigo in a goat. (9194303)
1997
22
Streptococcal impetigo among aboriginal children in Malaysia. (9139400)
1995
23
Twin sisters with impetigo herpetiformis. (8903778)
1995
24
Double-blind study comparing erythromycin and mupirocin for treatment of impetigo in children: implications of a high prevalence of erythromycin-resistant Staphylococcus aureus strains. (1605593)
1992
25
Mupirocin in the treatment of impetigo. (1737680)
1992
26
Impetigo. (1899777)
1991
27
Increasing the antibiotic spectrum in the treatment of impetigo. (2305732)
1990
28
Two sisters with impetigo herpetiformis. (2805396)
1989
29
Diagnosis and treatment of impetigo. (2913075)
1989
30
Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole. (3069760)
1988
31
Impetigo contagiosa: a comparison of erythromycin and dicloxacillin therapy. (3045781)
1988
32
Bullous impetigo and localized scalded skin syndrome in the elderly. (3623889)
1987
33
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
34
Topical antibiotic treatment of impetigo with mupirocin. (3096221)
1986
35
What histologic finding distinguishes superficial pemphigus and bullous impetigo? (6375421)
1984
36
Some aspects of impetigo herpetiformis. (7059209)
1982
37
Sequential bullous impetigo and cutaneous Herpes simplex virus infection. (6761658)
1982
38
A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. (7028065)
1981
39
Bullous impetigo caused by Streptococcus salivarius: a case report. (7002959)
1980
40
Letter: Telephoners' impetigo. (952547)
1976
41
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
42
Impetigo herpetiformis in two successive pregnancies. (4286099)
1966
43
The treatment of impetigo. (13322803)
1956
44
Three cases of acute nephritis occurring simultaneously in a family following impetigo contagiosa. (14392361)
1955
45
Impetigo and acute infectious exfoliative dermatitis of the newborn infant (Ritter's disease). (14955740)
1952
46
On impetigo herpetiformis. (14822640)
1951
47
Chronic symmetric impetigo. (18110559)
1949
48
Impetigo Herpetiformis.A ? Pemphigus Vegetans. (20917911)
1947
49
Impetigo bullosa in the tropics. (21065466)
1945
50
Bullous Purpura following Impetigo. (19973963)
1909

Variations for Impetigo

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Expression for genes affiliated with Impetigo

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for genes affiliated with Impetigo

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Pathways related to Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EDNRA, EDNRB
29.9EDNRA, EDNRB
39.9EDNRA, EDNRB
4
Show member pathways
9.8DSG3, DSG1
59.7CD79A, CD40LG

Compounds for genes affiliated with Impetigo

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Impetigo according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1[125i]et-13010.3EDNRB, EDNRA
2pd 1450654610.3EDNRB, EDNRA
3sitaxsentan46 3011.3EDNRB, EDNRA
4bq6104610.3EDNRB, EDNRA
5pd 1428934610.3EDNRB, EDNRA
6bq 302046 3011.3EDNRB, EDNRA
7ambrisentan46 3011.3EDNRB, EDNRA
8irl 162046 3011.3EDNRB, EDNRA
9fr13931746 3011.3EDNRB, EDNRA
10sarafotoxin4610.3EDNRB, EDNRA
11darusentan46 3011.3EDNRB, EDNRA
12atrasentan4610.3EDNRA, EDNRB
13tezosentan4610.3EDNRA, EDNRB
14bq78846 3011.2EDNRA, EDNRB
15bq12346 3011.2EDNRA, EDNRB
16bosentan46 1211.2EDNRB, EDNRA
17sulfolipid i4610.1CD79A, CD40LG
18sandoglobulin4610.1CD79A, CD40LG
19gamma globulin4610.0CD79A, CD40LG
20vancomycin46 1210.9CD79A, CD40LG
21pneumococcal469.9CD40LG, CD79A
22blys469.9CD40LG, CD79A
23sulfonamide469.9EDNRA, EDNRB
24tuberculin469.9CD40LG, CD79A
25praziquantel46 1210.8CD40LG, CD79A
26hemocyanin469.8CD79A, CD40LG
27rituximab46 52 1211.8CD40LG, CD79A, DSG1
28gliadin469.8CD40LG, CD79A
29prednisolone46 30 1211.6CD79A, DSG3, EDNRA
30toxin a469.6DSG3, DSG1, EDNRA, EDNRB
31pmma469.6CD40LG, CD79A
32formaldehyde46 2510.6EDNRA, CD79A, CD40LG
33indomethacin46 30 62 1212.5CD40LG, CD79A, EDNRA, EDNRB
34norepinephrine46 25 1211.5CD40LG, CD79A, EDNRA, EDNRB
35pge2469.4CD40LG, CD79A, EDNRA, EDNRB
36histamine46 30 2511.4EDNRA, PI3, CD79A, CD40LG
37ivig469.4DSG1, DSG3, CD79A, CD40LG
38silicone469.4CD40LG, CD79A
39dopamine46 30 25 1212.2EDNRA, NR4A1, CD79A, CD40LG
40steroid469.1EDNRB, EDNRA, PI3, NR4A1, CD79A
41vegf468.9EDNRB, EDNRA, NR4A1, CD79A, CD40LG
42alanine468.9EDNRB, EDNRA, NR4A1, CD79A, CD40LG
43testosterone46 62 25 1211.9EDNRA, NR4A1, CD79A, CD40LG
44acetylcholine46 52 30 25 1212.8EDNRB, EDNRA, DSG1, DSG3, CD79A, CD40LG
45retinoic acid46 259.7EDNRB, PI3, DSG1, NR4A1, CD79A, CD40LG
46cyclosporin a46 30 6210.7EDNRB, EDNRA, PI3, NR4A1, CD79A, CD40LG
47dexamethasone46 52 30 1211.7EDNRB, EDNRA, PI3, NR4A1, CD79A, CD40LG
48cysteine468.7EDNRB, EDNRA, PI3, NR4A1, CD79A, CD40LG
49calcium46 52 25 1211.4EDNRB, EDNRA, PI3, DSG4, DSG1, DSG3
50serine468.4EDNRB, EDNRA, PI3, DSG1, DSG3, NR4A1

GO Terms for genes affiliated with Impetigo

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17Gene Ontology
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Cellular components related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.1DSG3, DSG1, DSG4
2plasma membraneGO:0058868.0EDNRA, DSG4, DSG1, DSG3, CD79A, CD40LG

Biological processes related to Impetigo according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:05067810.0EDNRA, EDNRB
2vasoconstrictionGO:04231010.0EDNRA, EDNRB
3enteric nervous system developmentGO:0484849.9EDNRB, EDNRA
4sensory perception of painGO:0192339.9EDNRA, EDNRB
5B cell proliferationGO:0421009.6CD40LG, CD79A
6homophilic cell adhesionGO:0071569.5DSG3, DSG1, DSG4
7cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG3, DSG1

Molecular functions related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.9EDNRA, EDNRB

Products for genes affiliated with Impetigo

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Sources for Impetigo

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet