MCID: IMP004
MIFTS: 41

Impetigo malady

Skin category

Summaries for Impetigo

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards: Impetigo, also known as impetigo nos, is related to bullous impetigo and pemphigus. An important gene associated with Impetigo is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Apoptotic cleavage of cell adhesion proteins. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Related mouse phenotype mortality/aging.

Disease Ontology:8 Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. the lesions in bullous (staphylococcal) impetigo, which are always caused by s aureus, are superficial, thin-walled, and bullous.

Wikipedia:64 Impetigo /ɪmpɨˈtaɪɡoʊ/ is a highly contagious bacterial skin infection most common among... more...

Aliases & Classifications for Impetigo

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

impetigo 8 10 34 61
impetigo nos 8


External Ids:

Disease Ontology8 DOID:8504
MeSH35 D007169
ICD9CM27 684
ICD1025 L01, L01.0

Related Diseases for Impetigo

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impetigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1bullous impetigo31.1EDNRB, EDNRA, DSG1
2pemphigus30.6DSG2, DSG1, DSG3, DSG4
3pemphigus vegetans30.1DSG1
4ritter's disease30.1DSG1, EDNRA, EDNRB
5acute poststreptococcal glomerulonephritis30.1SKA1, SKA2, EDNRB
6pemphigus foliaceus30.1DSG3, DSG1, DSG2
7toxic shock syndrome29.8SPEG, EDNRA
8impetigo herpetiformis10.9
9atopic dermatitis10.3
10hypoparathyroidism10.2
11pharyngitis10.2
12ecthyma10.2
13miliaria rubra10.1
14generalized pustular psoriasis10.1
15carbuncle10.1
16alopecia10.1
17exfoliative dermatitis10.1
18nephritis10.1
19herpetiform pemphigus10.1
20superficial pemphigus10.1
21scarlet fever10.0EDNRA
22netherton syndrome10.0DSG1
23keratoacanthoma10.0DSG3
24subcorneal pustular dermatosis10.0DSG1
25erysipelas10.0PI3
26hepatopulmonary syndrome10.0EDNRB
27bullous skin disease10.0DSG1, DSG3
28tonsillitis10.0HSF4, EDNRA
29dermatitis10.0DSG3, DSG1
30exfoliation syndrome10.0EDNRA, EDNRB
31cystic kidney10.0EDNRA, EDNRB
32epidermolysis bullosa acquisita10.0DSG1
33impotence10.0EDNRB, EDNRA
34glomerulonephritis10.0EDNRB
35pemphigus vulgaris10.0DSG2, DSG1, DSG3, DSG4
36mucoepidermoid carcinoma10.0SUMF2, AGR3, NR4A1
37squamous cell carcinoma10.0EDNRB, PI3, DSG3, DSG1, DSG2
38diaper rash9.9
39intrahepatic cholestasis9.9
40chronic granulomatous disease9.9
41cellulitis9.9
42systemic lupus erythematosus9.9
43immune-complex glomerulonephritis9.9
44rickets9.9
45pyomyositis9.9
46chickenpox9.9
47streptococcal meningitis9.9
48adult syndrome9.9
49acute proliferative glomerulonephritis9.9
50tinea capitis9.9

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to impetigo

Clinical Features for Impetigo

Drugs & Therapeutics for Impetigo

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Impetigo

Drug clinical trials:

Search ClinicalTrials for Impetigo

Search NIH Clinical Center for Impetigo

Search CenterWatch for Impetigo

Genetic Tests for Impetigo

Anatomical Context for Impetigo

Animal Models for Impetigo or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Impetigo:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6SPEG, EDNRB, EDNRA, NR4A1, DSG4, DSG3

Publications for Impetigo

Sources:
51PubMed
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Articles related to Impetigo:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature. (23626548)
2013
2
Community-associated methicillin-resistant Staphylococcus aureus and impetigo. (20199556)
2010
3
Are lifetime prevalence of impetigo, molluscum and herpes infection really increased in children having atopic dermatitis? (20971618)
2010
4
Retapamulin for impetigo and other infections. (18832258)
2008
5
Spotlight on retapamulin in impetigo and other uncomplicated superficial skin infections. (18973410)
2008
6
Information from your family doctor. Impetigo: what you should know. (17390598)
2007
7
FPIN's clinical inquiries. Treatment of impetigo. (17375518)
2007
8
Impetigo: incidence and treatment in Dutch general practice in 1987 and 2001--results from two national surveys. (16433791)
2006
9
Impetigo herpetiformis: menstrual exacerbations for 7 years postpartum. (15987295)
2005
10
Bullous impetigo of the face after epilation by threading. (16172329)
2005
11
Facial and perioral primary impetigo: a clinical study. (16161401)
2005
12
Tinea faciei in an infant caused by Microsporum gypseum simulating a dry impetigo. (16354256)
2005
13
Bacteriological etiology of impetigo. (16509260)
2004
14
Treatment of impetigo: save mupirocin. (15499129)
2004
15
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. (12093888)
2002
16
Fusidic acid cream for impetigo. Emergence of resistance to fusidic acid limits its use. (12053928)
2002
17
A case of impetigo herpetiformis with unusual clinical features. (11476115)
2001
18
Association between lesional or non lesional S. aureus strains from patients with impetigo and exfoliative toxin production. No association with SmaI PFGE patterns. (10946402)
2000
19
What's your assessment? Impetigo. (10670342)
1999
20
Tinea corporis with secondary impetigo associated with silicone gel sheeting. (9915216)
1999
21
Biofilm formation of Staphylococcus aureus strains isolated from impetigo and furuncle: role of fibrinogen and fibrin. (9438901)
1997
22
Impetigo in childhood: changing epidemiology and new treatments. (8510990)
1993
23
Double-blind study comparing erythromycin and mupirocin for treatment of impetigo in children: implications of a high prevalence of erythromycin-resistant Staphylococcus aureus strains. (1605593)
1992
24
Is penicillin still the drug of choice for non-bullous impetigo? (1681172)
1991
25
Increasing the antibiotic spectrum in the treatment of impetigo. (2305732)
1990
26
Impetigo. Current etiology and comparison of penicillin, erythromycin, and cephalexin therapies. (2244610)
1990
27
Etiology and therapy of impetigo: reconsidered. (2305731)
1990
28
Impetigo herpetiformis: response to steroids and etretinate. (2583898)
1989
29
Impetigo: a reassessment of etiology and therapy. (3122189)
1987
30
Study of impetigo and the resistance pattern of the isolates to various antibiotics. (3123738)
1987
31
Impetigo and other skin infections. (3112643)
1987
32
Comparative and non-comparative studies of the efficacy and tolerance of tioconazole cream 1% versus another imidazole and/or placebo in neonates and infants with candidal diaper rash and/or impetigo. (3817280)
1987
33
Topical antibiotic treatment of impetigo with mupirocin. (3096221)
1986
34
A clinical trial of hydrocortisone/potassium hydroxyquinoline sulphate ('Quinocort') in the treatment of infected eczema and impetigo in general practice. (3299393)
1986
35
Falsely normal direct immunofluorescent microscopic fundings in bullous impetigo. (7027964)
1981
36
How I treat impetigo. (7401998)
1980
37
Treatment of impetigo and ecthyma. (359752)
1978
38
Oral manifestations of impetigo: report of two cases. (270584)
1977
39
Therapy of impetigo and furunculosis. (5537340)
1970
40
Impetigo. Bacteriologic features and renal involvement. (5946549)
1966
41
On the staphylococcal and streptococcal etiology of impetigo. (13921894)
1961
42
Impetigo herpetiformis; some aspects of the endocrinological pathogenesis. (13594211)
1958
43
Chronic vesicular impetigo of the trunk; 2 cases. (14834204)
1951
44
A case for diagnosis (dermatitis herpetiformis; impetigo herpetiformis?). (21015892)
1946
45
Penicillin ointment in the treatment of impetigo neonatorum. (21004770)
1945
46
Treatment of impetigo herpetiformis in pregnant women with hormones. (21005770)
1945
47
An Outbreak of Bullous Impetigo Neonatorum. (20784840)
1943
48
Economy in the Treatment of Impetigo and Scabies. (20783813)
1941
49
A NOTE ON TREATMENT OF IMPETIGO. (20777532)
1933
50
Photographs of Demodex Impetigo. (19982836)
1923

Genetic Variations for Impetigo

Expression for genes affiliated with Impetigo

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for genes affiliated with Impetigo

Sources:
54Reactome
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Pathways related to Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8DSG2, DSG1, DSG3
29.8DSG2, DSG1, DSG3

Compounds for genes affiliated with Impetigo

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Impetigo according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1[125i]et-12910.4EDNRA, EDNRB
2pd 1450654510.4EDNRB, EDNRA
3sitaxsentan45 2911.4EDNRB, EDNRA
4pd 1428934510.4EDNRB, EDNRA
5bq6104510.4EDNRB, EDNRA
6bq 302045 2911.4EDNRB, EDNRA
7ambrisentan45 2911.4EDNRB, EDNRA
8irl 162045 2911.4EDNRA, EDNRB
9tezosentan4510.4EDNRA, EDNRB
10Sitaxentan1110.3EDNRA, EDNRB
11fr13931745 2911.3EDNRB, EDNRA
12sarafotoxin4510.3EDNRB, EDNRA
13atrasentan4510.3EDNRB, EDNRA
14darusentan45 2911.2EDNRB, EDNRA
15bq78845 2911.2EDNRB, EDNRA
16bq12345 2911.2EDNRA, EDNRB
17bosentan45 1111.1EDNRA, EDNRB
18toxin a4510.0DSG1, DSG3, EDNRA, EDNRB
19acetylcholine45 50 29 11 2413.6EDNRB, EDNRA, DSG3, DSG1
20cyclosporin a45 29 6011.5NR4A1, PI3, EDNRA, EDNRB
21calcium45 50 11 2411.3EDNRB, EDNRA, PI3, NR4A1, DSG4, DSG3

GO Terms for genes affiliated with Impetigo

Sources:
16Gene Ontology
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Cellular components related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:0009409.8SKA1, SKA2
2desmosomeGO:0300579.3DSG2, DSG1, DSG3, DSG4

Biological processes related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:05067810.1EDNRB, EDNRA
2enteric nervous system developmentGO:04848410.1EDNRA, EDNRB
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.9DSG2, DSG1, DSG3
4vasoconstrictionGO:0423109.8EDNRA, EDNRB
5regulation of microtubule polymerization or depolymerizationGO:0311109.7SKA2, SKA1
6homophilic cell adhesionGO:0071569.7DSG2, DSG1, DSG3, DSG4

Molecular functions related to Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:00496210.1EDNRA, EDNRB

Products for genes affiliated with Impetigo

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Impetigo

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet