Aliases & Classifications for Impetigo

MalaCards integrated aliases for Impetigo:

Name: Impetigo 12 41 3 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8504
ICD10 33 L01 L01.0 L01.00
ICD9CM 35 684
MeSH 42 D007169
NCIt 47 C99088
UMLS 69 C0021099

Summaries for Impetigo

MedlinePlus : 41 impetigo is a skin infection caused by bacteria. it is usually caused by staphylococcal (staph) bacteria, but it can also be caused by streptococcal (strep) bacteria. it is most common in children between the ages of two and six. it usually starts when bacteria get into a break in the skin, such as a cut, scratch, or insect bite. symptoms start with red or pimple-like sores surrounded by red skin. these sores can be anywhere, but usually they occur on your face, arms and legs. the sores fill with pus, then break open after a few days and form a thick crust. they are often itchy, but scratching them can spread the sores. impetigo can spread by contact with sores or nasal discharge from an infected person. you can treat impetigo with antibiotics. nih: national institute of allergy and infectious diseases

MalaCards based summary : Impetigo is related to bullous impetigo and impetigo herpetiformis, and has symptoms including exanthema, fever and pruritus. An important gene associated with Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Lung fibrosis and amb2 Integrin signaling. The drugs Fusidic Acid and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver.

CDC : 3 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Disease Ontology : 12 A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

Wikipedia : 72 Impetigo is a bacterial infection that involves the superficial skin. The most common presentation is... more...

Related Diseases for Impetigo

Diseases related to Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 bullous impetigo 12.3
2 impetigo herpetiformis 12.2
3 pyoderma 11.3
4 ecthyma 11.1
5 prolidase deficiency 10.7
6 acute proliferative glomerulonephritis 10.7
7 scarlet fever 10.7
8 necrotizing fasciitis 10.7
9 enterovesical fistula 10.5 CALCA PI3
10 acute pulmonary heart disease 10.5 DSG1 IL36RN
11 placenta praevia 10.4 ELANE PI3
12 hemangioma of orbit 10.4 ELANE PI3
13 pyridoxine deficiency 10.4 ELANE IL36RN
14 labyrinthine bilateral reactive loss 10.3 ELANE IL6
15 pancreatic cystadenoma 10.2 ELANE HSF4
16 nodular prostate 10.2 CALCA IL6
17 high pressure neurological syndrome 10.2 CALCA IL6
18 central hypoventilation syndrome, congenital 10.2 CALCA EDNRB
19 cholera 10.2 ELANE IL6
20 hemopericardium 10.2 CALCA EDNRB
21 carcinoma arising in nasal papillomatosis 10.1 IL6 PI3
22 physical disorder 10.1 CALCA IL6
23 conjunctival concretion 10.1 DSG1 IL6
24 bardet-biedl syndrome 8 10.1 ELANE IL6
25 diastrophic dysplasia 10.1 DSG1 ELANE PI3
26 bullous pemphigoid 10.1 ELANE IL36RN PI3
27 pyridoxal 5'-phosphate-dependent epilepsy 10.1 ELANE IL36RN PI3
28 alcohol abuse 10.1 ELANE IL6
29 dermatitis 10.1
30 scabies 10.1
31 pemphigus 10.1
32 glomerulonephritis 10.0
33 tetanus 10.0 CALCA ELANE PI3
34 neonatal period electroclinical syndrome 10.0 ELANE IL6
35 lung lymphoma 10.0 CALCA MYOM2
36 atopic dermatitis 10.0
37 psoriasis 10.0
38 germ cell and embryonal cancer 9.9 ELANE IL6
39 arteriosclerosis 9.9 ELANE MYOM2
40 pharyngitis 9.9
41 pustular psoriasis 9.9
42 shigellosis 9.9 ELANE HSF4 PI3
43 adenocarcinoid tumor 9.9 ELANE IL6 PI3
44 spirillary rat-bite fever 9.9 IL6 MYOM2
45 generalized atherosclerosis 9.9 IL6 MYOM2
46 bipolar i disorder 9.9 IL6 MYOM2
47 ragweed sensitivity 9.9 ELANE IL6
48 acute chest syndrome 9.9 ELANE IL6
49 indolent myeloma 9.9 IL6 MYOM2
50 orthostatic proteinuria 9.8 IL6 MYOM2

Comorbidity relations with Impetigo via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Impetigo:



Diseases related to Impetigo

Symptoms & Phenotypes for Impetigo

UMLS symptoms related to Impetigo:


exanthema, fever, pruritus

Drugs & Therapeutics for Impetigo

Drugs for Impetigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fusidic Acid Approved Phase 4,Phase 3 6990-06-3 3000226
2
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
3
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
4
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antiparasitic Agents Phase 4
8
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
9
Mupirocin Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 12650-69-0 446596
10
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
11
Zinc Approved Phase 3 7440-66-6 32051 23994
12 Antipruritics Phase 2, Phase 3
13 Dermatologic Agents Phase 2, Phase 3
14 Expectorants Phase 2, Phase 3
15 Respiratory System Agents Phase 2, Phase 3
16 Terpin Phase 2, Phase 3
17 Antibiotics, Antitubercular Phase 3,Phase 2
18 methicillin Phase 3
19 Micronutrients Phase 3
20 Trace Elements Phase 3
21
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
22 Papaya Approved, Nutraceutical Phase 1
23
Albendazole Approved, Vet_approved 54965-21-8 2082
24
Diethylcarbamazine Approved, Vet_approved 90-89-1 3052
25 Vaccines
26 Anthelmintics
27 Antimitotic Agents
28 Antiprotozoal Agents
29 Lipoxygenase Inhibitors
30 Liver Extracts

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection Completed NCT01126268 Phase 4 Retapamulin (Altabax)
2 Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections. Completed NCT00555061 Phase 4 Retapamulin Ointment, 1%
3 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
4 Fucidin® Cream in the Treatment of Impetigo Terminated NCT00986856 Phase 4 Fucidin® cream
5 Citriodiol® and Impetigo Unknown status NCT01611909 Phase 2, Phase 3 p-menthane-3,8-diol oil
6 Treatment Of Impetigo With Topical SB-275833 Ointment, 1% Versus Topical Placebo Ointment Completed NCT00133848 Phase 3 SB-275833 ointment, 1%
7 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
8 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream
9 Vehicle Controlled Efficacy and Safety Study of Two Dose Regimens of CD07223 1.5% Topical Gel in Impetigo Completed NCT01670032 Phase 2, Phase 3 Experimental: CD07223 1.5 % Topical Gel BID;Experimental: CD07223 1.5% Topical Gel TID;Placebo Comparator: CD07223 vehicle gel BID;Placebo Comparator: CD07223 vehicle gel TID
10 Topical SB-275833 Ointment, 1% For The Treatment Of Impetigo Completed NCT00133874 Phase 3 SB-275833 ointment, 1%
11 Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA Completed NCT00852540 Phase 3 Retpamulin Ointment, 1%;Linezolid
12 Immunological and Clinical Responses to Zinc in Children With Diarrhoea Completed NCT00408356 Phase 3 Zinc
13 Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Impetigo Patients Completed NCT01171326 Phase 2 Topical Minocycline Foam FXFM244
14 The Pharmacokinetics of 2% TD1414 Cream in Adults With Secondarily Infected Traumatic Lesions (SITL) or Impetigo Completed NCT00758862 Phase 2 2% TD1414 Cream
15 A Phase II Study to Evaluate the Efficacy and Safety of Two Doses of LTX-109 in Impetigo Completed NCT01803035 Phase 2 LTX-109 1 %;LTX-109 2 %;Placebo gel
16 Safety and Efficacy of Topical NVC-422 Gel in Impetigo Completed NCT01367314 Phase 2 NVC-422
17 Efficacy, Safety, and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL) Completed NCT00626795 Phase 2 TD1414 2% cream;TD1414 2% cream;Bactroban® (mupirocin) 2% cream
18 A Study to Evaluate Safety, Tolerability and Efficacy of Lytixarâ„¢ (LTX-109) on Uncomplicated, Gram-positive, Skin Infection Completed NCT01223222 Phase 2 LTX-109
19 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Recruiting NCT02902822 Phase 2
20 The Efficacy and Safety of Topical Papaya (Carica Papaya) Leaf Extract 1% Ointment Versus Mupirocin 2% Ointment in the Treatment of Limited Impetigo: a Randomized, Double-blind, Controlled Clinical Trial Unknown status NCT01943136 Phase 1 papaya 1% extract ointment;mupirocin 2% ointment
21 EU PV for Retapamulin-Prescribing Completed NCT01153828 Retapamulin;Co-prescription of retapamulin and topical mupirocin;Co-prescription of retapamulin and topical fusidic acid
22 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
23 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
24 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276
25 United States Pharmacovigilence Retapamulin-Prescribing Completed NCT01153880 Retapamulin;Co-prescription of retapamulin and topical mupirocin
26 ALTARGO(Retapamulin) PMS(Post-marketing Surveillance) Completed NCT01445600 ALTARGO(retapamulin)
27 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Impetigo

Cochrane evidence based reviews: impetigo

Genetic Tests for Impetigo

Anatomical Context for Impetigo

MalaCards organs/tissues related to Impetigo:

39
Skin, Eye, Liver, Colon, Neutrophil, Monocytes, T Cells

Publications for Impetigo

Articles related to Impetigo:

(show top 50) (show all 471)
id Title Authors Year
1
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
2
Impetigo ( 28613693 )
2017
3
Community-Based Prescribing for Impetigo in Remote Australia: An Opportunity for Antimicrobial Stewardship. ( 28748178 )
2017
4
Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. ( 28579477 )
2017
5
Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections. ( 28671945 )
2017
6
Incremental Contributions of FbaA and Other Impetigo-Associated Surface Proteins to Fitness and Virulence of a Classical Group A Streptococcal Skin Strain. ( 28808160 )
2017
7
Management of impetigo and cellulitis: Simple considerations for promoting appropriate antibiotic use in skin infections. ( 28807958 )
2017
8
Diagnosis and management of impetigo. ( 28178083 )
2017
9
The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial. ( 28722612 )
2017
10
Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. ( 28270312 )
2017
11
The Importance of Scabies Coinfection in the Treatment Considerations for Impetigo. ( 26599569 )
2016
12
Impetigo and scabies - Disease burden and modern treatment strategies. ( 27180311 )
2016
13
Tissue tropisms in group A Streptococcus: what virulence factors distinguish pharyngitis from impetigo strains? ( 26895573 )
2016
14
Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings. ( 27659511 )
2016
15
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. ( 27617460 )
2016
16
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. ( 27599660 )
2016
17
"EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern. ( 26821848 )
2016
18
Crusted impetigo-like lesion on the face: a case of IgG/IgA pemphigus. ( 27879012 )
2016
19
Staphylococcal bullous impetigo in a neonate. ( 27458596 )
2016
20
An association between newly diagnosed cutaneous T cell lymphoma and prior impetigo: a nested case-control study. ( 27613059 )
2016
21
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
22
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. ( 27573023 )
2016
23
Topical Minocycline Foam for the Treatment of Impetigo in Children: Results of a Randomized, Double-Blind, Phase 2 Study. ( 27741342 )
2016
24
Where to from here? The treatment of impetigo in children as resistance to fusidic acid emerges. ( 27736855 )
2016
25
A Case of Tinea Corporis due to Trichophyton tonsurans that Manifested as Impetigo. ( 27581776 )
2016
26
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
27
The Prevalence of Scabies and Impetigo in the Solomon Islands: A Population-Based Survey. ( 27348119 )
2016
28
Impetigo contagiosa in a zosteriform pattern. ( 27333861 )
2016
29
Staphylococcus aureus penetrate the interkeratinocyte spaces created by skin-infiltrating neutrophils in a mouse model of impetigo. ( 27862501 )
2016
30
Photodynamic Antibacterial Enhanced Effect Of Methylene Blue-Gold Nanoparticles Conjugate On Staph Aureus Isolated From Impetigo Lesions In Vitro Study. ( 25827622 )
2015
31
Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. ( 26104679 )
2015
32
Fabric-skin models to assess infection transfer for impetigo contagiosa in a kindergarten scenario. ( 25666081 )
2015
33
Scabies and impetigo prevalence and risk factors in Fiji: a national survey. ( 25738499 )
2015
34
Allergic Contact Dermatitis to Benzoyl Peroxide Resembling Impetigo. ( 25782705 )
2015
35
Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus. ( 26135320 )
2015
36
Prevalence of scabies and impetigo worldwide: a systematic review. ( 26088526 )
2015
37
Impetigo contagiosa with Nikolsky sign in adult patient of advanced malignant melanoma. ( 26173486 )
2015
38
Zosteriform impetigo: Wolf's isotopic response in a cutaneous immunocompromised district. ( 26336623 )
2015
39
Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae ) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. ( 25855021 )
2015
40
The Global Epidemiology of Impetigo: A Systematic Review of the Population Prevalence of Impetigo and Pyoderma. ( 26317533 )
2015
41
Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo. ( 25876581 )
2015
42
Impetigo: diagnosis and treatment. ( 25250996 )
2014
43
Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis. ( 25413895 )
2014
44
Bullous impetigo. ( 24736928 )
2014
45
A Randomized, Double-blind, Comparative Study to Assess the Safety and Efficacy of Topical Retapamulin Ointment 1% Versus Oral Linezolid in the Treatment of Secondarily Infected Traumatic Lesions and Impetigo Due to Methicillin-Resistant Staphylococcus aureus. ( 25396674 )
2014
46
Extensive pustules in a neonate. Diagnosis: impetigo neonatorum. ( 25187389 )
2014
47
Systemic bioavailability and safety of twice-daily topical ozenoxacin 1% cream in adults and children with impetigo. ( 25209523 )
2014
48
The decline of the impetigo epidemic caused by the epidemic European fusidic acid-resistant impetigo clone: an 11.5-year population-based incidence study from a community in Western Norway. ( 25229166 )
2014
49
Case report of a rare dermatosis in pregnancy: Impetigo herpetiformis. ( 25303404 )
2014
50
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014

Variations for Impetigo

Expression for Impetigo

Search GEO for disease gene expression data for Impetigo.

Pathways for Impetigo

Pathways related to Impetigo according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.06 CALCA IL6
2 10.84 ELANE IL6
3 10.61 CALCA IL6
4 10.15 CALCA EDNRB

GO Terms for Impetigo

Cellular components related to Impetigo according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 DSG1 PI3

Biological processes related to Impetigo according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.58 EDNRB ELANE IL6
2 aging GO:0007568 9.54 CALCA EDNRB IL6
3 regulation of blood pressure GO:0008217 9.51 CALCA EDNRB
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.49 ELANE IL6
5 antimicrobial humoral response GO:0019730 9.48 ELANE PI3
6 response to heat GO:0009408 9.46 CALCA IL6
7 monocyte chemotaxis GO:0002548 9.43 CALCA IL6
8 vasodilation GO:0042311 9.32 CALCA EDNRB
9 response to pain GO:0048265 9.26 CALCA EDNRB
10 negative regulation of bone resorption GO:0045779 9.16 CALCA IL6
11 response to yeast GO:0001878 8.96 ELANE IL6
12 negative regulation of chemokine biosynthetic process GO:0045079 8.62 ELANE IL6

Sources for Impetigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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